Expression and distribution of the sweet taste receptor isoforms T1R2 and T1R3 in human and rat bladders

Journal of Urology

Volumn 186, Issue 6, 2011, Pages 2455-2462

  Elliott, Ruth A ^a   Kapoor, Shalini ^a   Tincello, Douglas G ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

overactive; saccharin; taste receptors; type 1; urinary bladder; urothelium

Indexed keywords

PARAFFIN; POTASSIUM CHLORIDE; RECEPTOR PROTEIN; SACCHARIN; SWEET TASTE RECEPTOR; SWEETENING AGENT; T1R2 PROTEIN; T1R3 PROTEIN; UNCLASSIFIED DRUG; ZINC;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLADDER; BLADDER CONTRACTION; CONTROLLED STUDY; ELECTROSTIMULATION; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; SWEETNESS; TISSUE HOMOGENATE; UROTHELIUM;

ANIMALS; FEMALE; HUMANS; PROTEIN ISOFORMS; RATS; RATS, WISTAR; RECEPTORS, G-PROTEIN-COUPLED; URINARY BLADDER;

EID: 80755136614     PISSN: 00225347     EISSN: 15273792     Source Type: Journal    
DOI: 10.1016/j.juro.2011.07.083     Document Type: Article

References (24)

1. P. Abrams, L. Cardozo, and M. Fall The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society Standardisation Sub-committee of the International Continence Society Neurourol Urodyn 21 2002 167
2. D.E. Irwin, I. Milsom, and S. Hunskaar Population-based survey of urinary incontinence, overactive bladder, and other lower urinary tract symptoms in five countries: results of the EPIC study Eur Urol 50 2006 1306
3. P. Abrams, C.J. Kelleher, and L.A. Kerr Overactive bladder significantly affects quality of life Am J Manag Care 6 2000 S580
4. K.E. Andersson Pharmacotherapy of the overactive bladder Discov Med 8 2009 118
5. H.M. Dallosso, C.W. McGrother, and R.J. Matthews The association of diet and other lifestyle factors with overactive bladder and stress incontinence: a longitudinal study in women BJU Int 92 2003 69
6. J. Dasgupta, R.A. Elliott, and A. Doshani Enhancement of rat bladder contraction by artificial sweeteners via increased extracellular Ca2+ influx Toxicol Appl Pharmacol 217 2006 216
7. 2+ influx Neurourol Urodyn 28 2009 542
8. R. Cartwright, S. Srikrishna, and L. Cardozoz Does Diet Coke cause overactive bladder? A 4-way crossover trial, investigating the effect of carbonated soft drinks on overactive bladder symptoms in normal volunteers Neurourol Urodyn 26 2007 626
9. R.F. Margolskee Molecular mechanisms of bitter and sweet taste transduction J Biol Chem 277 2002 1
10. X. Li, L. Staszewski, and H. Xu Human receptors for sweet and umami taste PNAS 99 2002 4692
11. Y. Nakagawa, M. Nagasawa, and S. Yamada Sweet taste receptor expressed in pancreatic β-cells activates the calcium and cyclic amp signaling systems and stimulates insulin secretion PLoS ONE 4 2009 1
12. O.J. Mace, J. Affleck, and N. Patel Sweet taste receptors in rat small intestine stimulates glucose absorption through apical GLUT2 J Physiol 582 2007 379
13. +-glucose co-transporter 1 Proc Natl Acad Sci U S A 104 2007 15075
14. X. Ren, L. Zhou, and R. Terwilliger Sweet taste signalling functions as a hypothalamic glucose sensor Front Integ Neurosci 3 2009 1
15. K. Iwasaki, and M. Sato Inhibition of taste nerve responses to sugars and amino acids by cupric and zinc ions in mice Chem Senses 11 1986 79
16. R.S.J. Keast, T.M. Canty, and P.A.S. Breslin Oral zinc sulphate solutions inhibit sweet taste perception Chem Senses 29 2004 513
17. R.S.J. Keast The effect of zinc on human taste perception J Food Sci 68 2003 1871
18. J. Chandrashekar, M.A. Hoon, and N.J.P. Ryba The receptors and cells for mammalian taste Nature 444 2006 288
19. G. Nelson, M.A. Hoon, and J. Chandrashekar Mammalian sweet taste receptors Cell 106 2001 381
20. B. Lindemann Receptors and transduction in taste Nature 413 2001 219
21. 2+ in response to sugars and non-sugar sweeteners in transduction of sweet taste in the rat J Physiol 490 1996 325
22. W. de Groat The urothelium in overactive bladder: passive bystander or active participant Urology 64 2004 7
23. L.A. Wilson, K. Wilkinson, H.M. Crews, and Davies Urinary monitoring of saccharin and acesulfame-k as biomarkers of exposure to these additives Food Addit Contam 16 1999 227
24. M.H. Hawthorn, C.R. Chapple, and M. Cock Urothelium-derived inhibitory factor(s) influences on detrusor muscle contractility in vitro Br J Pharmacol 129 2000 416