Knock-out of the potassium channel TASK-1 leads to a prolonged qt interval and a disturbed QRS complex

Cellular Physiology and Biochemistry

Volumn 28, Issue 1, 2011, Pages 77-86

  Decher, Niels ^a   Wemhöner, Konstantin ^a   Rinné, Susanne ^a   Netter, Michael F ^a   Zuzarte, Marylou ^a   Aller, Maria I ^b   Kaufmann, Susann G ^c   Li, Xian Tao ^a   Meuth, Sven G ^d   Daut, Jürgen ^a   Sachse, Frank B ^e   Maier, Sebastian K G ^c  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

^b MIGUEL HERNÁNDEZ UNIVERSITY   (Spain)

^c Abteilung Innere Medizin   (Germany)

^d UNIVERSITY OF MÜNSTER   (Germany)

^e UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

Cardiac repolarization; In vivo electrophysiology; Prolonged QT interval; TASK 1 knock out; Ventricular arrhythmias

Indexed keywords

A 293; ISOFLURANE; METHOXAMINE; POTASSIUM CHANNEL; POTASSIUM CHANNEL BLOCKING AGENT; POTASSIUM CHANNEL TASK 1; UNCLASSIFIED DRUG;

ACTION POTENTIAL; ADRENERGIC STIMULATION; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; ATRIOVENTRICULAR CONDUCTION; CONTROLLED STUDY; ECG ABNORMALITY; ELECTROCARDIOGRAPHY MONITORING; FEMALE; GENETIC TRANSCRIPTION; HEART ELECTROPHYSIOLOGY; HEART HEMODYNAMICS; HEART MUSCLE CELL; HEART MUSCLE CONDUCTION SYSTEM; HEART RATE; MALE; MOUSE; NONHUMAN; PATCH CLAMP; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QRS COMPLEX; QT PROLONGATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WILD TYPE;

ANIMALIA; MUS;

EID: 80052016639     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000331715     Document Type: Article

References (30)

1. Nerbonne JM, Kass RS: Molecular physiology of cardiac repolarization. Physiol Rev 2005;85:1205-1253. (Pubitemid 41362269)
2. Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N: Potassium leak channels and the KCNK family of two-P-domain subunits. Nat Rev Neurosci 2001;2:175-184. (Pubitemid 33673370)
3. Kim D: Fatty acid-sensitive two-pore domain K+ channels. Trends Pharmacol Sci 2003;24:648-654. (Pubitemid 37494787)
4. Lopes CM, Gallagher PG, Buck ME, Butler MH, Goldstein SA: Proton block and voltage gating are potassium-dependent in the cardiac leak channel Kcnk3. J Biol Chem 2000;275:16969-16978. (Pubitemid 30398937)
5. Kim Y, Bang H, Kim D: TBAK-1 and TASK-1, two-pore K+ channel subunits: kinetic properties and expression in rat heart. Am J Physiol 1999;277:H1669-1678.
6. Putzke C, Wemhöner K, Sachse FB, Rinné S, Schlichthörl G, Li XT, Jae L, Eckhardt I, Wischmeyer E, Wulf H, Preisig-Müller R, Daut J, Decher N: The acid-sensitive potassium channel TASK-in rat cardiac muscle. Cardiovasc Res 2007;75:59-68. (Pubitemid 46873507)
7. Donner BC, Schullenberg M, Geduldig N, Huning A, Mersmann J, Zacharowski K, Kovacevic A, Decking U, Aller MI, Schmidt KG: Functional role of TASK-1 in the heart: studies in TASK-1-deficient mice show prolonged cardiac repolarization and reduced heart rate variability. Basic Res Cardiol 2011;106:75-87.
8. Graham V, Zhang H, Willis S, Creazzo TL: Expression of a two-pore domain K+ channel (TASK-1) in developing avian and mouse ventricular conduction systems. Dev Dyn 2006;235:143-151. (Pubitemid 46939711)
9. Putzke C, Hanley PJ, Schlichthörl G, Preisig-Müller R, Rinné S, Anetseder M, Eckenhoff R, Berkowitz C, Vassiliou T, Wulf H, Eberhart L: Differential effects of volatile and intravenous anesthetics on the activity of human TASK-1. Am J Physiol Cell Physiol 2007;293:C1319-1326. (Pubitemid 47556730)
10. Sirois JE, Lei Q, Talley EM, Lynch C 3rd, Bayliss DA: The TASK-1 two-pore domain K+ channel is a molecular substrate for neuronal effects of inhalation anesthetics. J Neurosci 2000;20:6347-6354.
11. Aller MI, Veale EL, Linden AM, Sandu C, Schwaninger M, Evans LJ, Korpi ER, Mathie A, Wisden W, Brickley SG: Modifying the subunit composition of TASK channels alters the modulation of a leak conductance in cerebellar granule neurons. J Neurosci 2005;25:11455-11467. (Pubitemid 43083717)
12. Guo W, Xu H, London B, Nerbonne JM: Molecular basis of transient outward K+ current diversity in mouse ventricular myocytes. J Physiol 1999;521:587-599. (Pubitemid 30042774)
13. Maier SK, Westenbroek RE, Schenkman KA, Feigl EO, Scheuer T, Catterall WA: An unexpected role for brain-type sodium channels in coupling of cell surface depolarization to contraction in the heart. Proc Natl Acad Sci USA 2002;99:4073-4078. (Pubitemid 34252231)
14. Wagner S, Dybkova N, Rasenack EC, Jacobshagen C, Fabritz L, Kirchhof P, Maier SK, Zhang T, Hasenfuss G, Brown JH, Bers DM, Maier LS: Ca2+/calmodulindependent protein kinase II regulates cardiac Na+ channels. J Clin Invest 2006;116:3127-3138. (Pubitemid 44878627)
15. Chan A, Isbister GK, Kirkpatrick CM, Dufful SB: Drug-induced QT prolongation and torsades de pointes: evaluation of a QT nomogram. QJM 2007;100:609-615. (Pubitemid 47543415)
16. Berul CI: Electrophysiological phenotyping in genetically engineered mice. Physiol Genomics 2003;13:207-216. (Pubitemid 37129186)
17. Schuh K, Quaschning T, Knauer S, Hu K, Kocak S, Roethlein N, Neyses L: Regulation of vascular tone in animals overexpressing the sarcolemmal calcium pump. J Biol Chem 2003;278:41246-41252. (Pubitemid 37280952)
18. Kim D, Fujita A, Horio Y, Kurachi Y: Cloning and functional expression of a novel cardiac two-pore background K+ channel (cTBAK-1). Circ Res 1998;82:513-518. (Pubitemid 28117333)
19. Duprat F, Lesage F, Fink M, Reyes R, Heurteaux C, Lazdunski M: TASK, a human background K+ channel to sense external pH variations near physiological pH. EMBO J 1997;16:5464-5471. (Pubitemid 27380153)
20. Heitzmann D, Derand R, Jungbauer S, Bandulik S, Sterner C, Schweda F, El Wakil A, Lalli E, Guy N, Mengual R, Reichold M, Tegtmeier I, Bendahhou S, Gomez-Sanchez CE, Aller MI, Wisden W, Weber A, Lesage F, Warth R, Barhanin J: Invalidation of TASK1 potassium channels disrupts adrenal gland zonation and mineralocorticoid homeostasis. EMBO J 2008;27:179-187.
21. Muhammad S, Aller MI, Maser-Gluth C, Schwaninger M, Wisden W: Expression of the kcnk3 potassium channel gene lessens the injury from cerebral ischemia, most likely by a general influence on blood pressure. Neuroscience 2010;167:758-764.
22. Berry CJ, Thedens DR, Light-McGroary K, Miller JD, Kutschke W, Zimmerman KA, Weiss RM: Effects of deep sedation or general anesthesia on cardiac function in mice undergoing cardiovascular magnetic resonance. J Cardiovasc Magn Reson 2009;11:16.
23. Roth DM, Swaney JS, Dalton ND, Gilpin EA, Ross J: Impact of anesthesia on cardiac function during echocardiography in mice. Am J Physiol Heart Circ Physiol 2002;282:H2134-2140. (Pubitemid 34663023)
24. Wehrens XH, Kirchhoff S, Doevendans PA: Mouse electrocardiography: an interval of thirty years. Cardiovasc Res 2000;45:231-237.
25. London B: Cardiac arrhythmias: from (transgenic) mice to men. J Cardiovasc Electrophysiol 2001;12:1089-1091. (Pubitemid 32846508)
26. Chandler NJ, Greener ID, Tellez JO, Inada S, Musa H, Molenaar P, Difrancesco D, Baruscotti M, Longhi R, Anderson RH, Billeter R, Sharma V, Sigg DC, Boyett MR, Dobrzynski H: Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker. Circulation 2009;119:1562-1575.
27. Lalevee N, Monier B, Senatore S, Perrin L, Semeriva M: Control of cardiac rhythm by ORK1, a Drosophila two-pore domain potassium channel. Curr Biol 2006;16:1502-1508. (Pubitemid 44142975)
28. Schott JJ, Alshinawi C, Kyndt F, Probst V, Hoorntje TM, Hulsbeek M, Wilde AA, Escande D, Mannens MM, Le Marec H: Cardiac conduction defects associate with mutations in SCN5A. Nat Genet 1999;23:20-21. (Pubitemid 29418782)
29. Schulze-Bahr E, Neu A, Friederich P, Kaupp UB, Breithardt G, Pongs O, Isbrandt D: Pacemaker channel dysfunction in a patient with sinus node disease. J Clin Invest 2003;111:1537-1545. (Pubitemid 38063286)
30. Gaborit N, Le Bouter S, Szuts V, Varro A, Escande D, Nattel S, Demolombe S: Regional and tissue specific transcript signatures of ion channel genes in the nondiseased human heart. J Physiol 2007;582:675-693. (Pubitemid 47040552)