메뉴 건너뛰기




Volumn 7, Issue 11, 2016, Pages 12623-12632

Expression of the bitter receptor T2R38 in pancreatic cancer: Localization in lipid droplets and activation by a bacteria-derived quorum-sensing molecule

Author keywords

ABCB1; Bitter receptor; Microbiome; Pancreatic cancer

Indexed keywords

FAT DROPLET; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; MULTIDRUG RESISTANCE PROTEIN 1; RECEPTOR PROTEIN; T2R38 PROTEIN; TRANSCRIPTION FACTOR NFAT; TRANSCRIPTION FACTOR NFATC1; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; G PROTEIN COUPLED RECEPTOR; LIPID DROPLET ASSOCIATED PROTEIN; PHENYLTHIOUREA; TASTE RECEPTORS, TYPE 2;

EID: 84962788258     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.7206     Document Type: Article
Times cited : (62)

References (45)
  • 2
    • 84947254692 scopus 로고    scopus 로고
    • Current Standards and Novel Treatment Options for Metastatic Pancreatic Adenocarcinoma
    • Weinberg BA, Yabar CS, Brody JR and Pishvaian MJ. Current Standards and Novel Treatment Options for Metastatic Pancreatic Adenocarcinoma. Oncology. 2015; 29:809-820, 886.
    • (2015) Oncology. , vol.29
    • Weinberg, B.A.1    Yabar, C.S.2    Brody, J.R.3    Pishvaian, M.J.4
  • 5
  • 7
    • 84938505828 scopus 로고    scopus 로고
    • Tasting Pseudomonas aeruginosa Biofilms: Human Neutrophils Express the Bitter Receptor T2R38 as Sensor for the Quorum Sensing Molecule N-(3-Oxododecanoyl)-l-Homoserine Lactone
    • Maurer S, Wabnitz GH, Kahle NA, Stegmaier S, Prior B, Giese T, Gaida MM, Samstag Y and Hansch GM. Tasting Pseudomonas aeruginosa Biofilms: Human Neutrophils Express the Bitter Receptor T2R38 as Sensor for the Quorum Sensing Molecule N-(3-Oxododecanoyl)-l-Homoserine Lactone. Frontiers in immunology. 2015; 6:369.
    • (2015) Frontiers in immunology. , vol.6 , pp. 369
    • Maurer, S.1    Wabnitz, G.H.2    Kahle, N.A.3    Stegmaier, S.4    Prior, B.5    Giese, T.6    Gaida, M.M.7    Samstag, Y.8    Hansch, G.M.9
  • 11
    • 84874746505 scopus 로고    scopus 로고
    • Sensing bacteria, without bitterness?
    • Viswanathan VK. Sensing bacteria, without bitterness? Gut microbes. 2013; 4:91-93.
    • (2013) Gut microbes. , vol.4 , pp. 91-93
    • Viswanathan, V.K.1
  • 13
    • 77952954544 scopus 로고    scopus 로고
    • Lipid droplets: a dynamic organelle moves into focus
    • Beller M, Thiel K, Thul PJ and Jackle H. Lipid droplets: a dynamic organelle moves into focus. FEBS letters. 2010; 584:2176-2182.
    • (2010) FEBS letters. , vol.584 , pp. 2176-2182
    • Beller, M.1    Thiel, K.2    Thul, P.J.3    Jackle, H.4
  • 21
    • 84871912893 scopus 로고    scopus 로고
    • Bacterial quorum sensing molecule induces chemotaxis of human neutrophils via induction of p38 and leukocyte specific protein 1 (LSP1)
    • Kahle NA, Brenner-Weiss G, Overhage J, Obst U and Hansch GM. Bacterial quorum sensing molecule induces chemotaxis of human neutrophils via induction of p38 and leukocyte specific protein 1 (LSP1). Immunobiology. 2013; 218:145-151.
    • (2013) Immunobiology. , vol.218 , pp. 145-151
    • Kahle, N.A.1    Brenner-Weiss, G.2    Overhage, J.3    Obst, U.4    Hansch, G.M.5
  • 24
    • 79960786009 scopus 로고    scopus 로고
    • Gut bitter taste receptor signalling induces ABCB1 through a mechanism involving CCK
    • Jeon TI, Seo YK and Osborne TF. Gut bitter taste receptor signalling induces ABCB1 through a mechanism involving CCK. The Biochemical journal. 2011; 438:33-37.
    • (2011) The Biochemical journal. , vol.438 , pp. 33-37
    • Jeon, T.I.1    Seo, Y.K.2    Osborne, T.F.3
  • 25
    • 33745769295 scopus 로고    scopus 로고
    • Taste receptors in the gastrointestinal tract. I. Bitter taste receptors and alpha-gustducin in the mammalian gut
    • Rozengurt E. Taste receptors in the gastrointestinal tract. I. Bitter taste receptors and alpha-gustducin in the mammalian gut. American journal of physiology Gastrointestinal and liver physiology. 2006; 291:G171-177.
    • (2006) American journal of physiology Gastrointestinal and liver physiology. , vol.291 , pp. G171-177
    • Rozengurt, E.1
  • 28
    • 34548514866 scopus 로고    scopus 로고
    • Proteins under new management: lipid droplets deliver
    • Welte MA. Proteins under new management: lipid droplets deliver. Trends in cell biology. 2007; 17:363-369.
    • (2007) Trends in cell biology. , vol.17 , pp. 363-369
    • Welte, M.A.1
  • 31
    • 84855325747 scopus 로고    scopus 로고
    • N-Acylhomoserine lactones are potent neutrophil chemoattractants that act via calcium mobilization and actin remodeling
    • Karlsson T, Musse F, Magnusson KE and Vikstrom E. N-Acylhomoserine lactones are potent neutrophil chemoattractants that act via calcium mobilization and actin remodeling. Journal of leukocyte biology. 2012; 91:15-26.
    • (2012) Journal of leukocyte biology. , vol.91 , pp. 15-26
    • Karlsson, T.1    Musse, F.2    Magnusson, K.E.3    Vikstrom, E.4
  • 32
    • 28944448306 scopus 로고    scopus 로고
    • The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone stimulates phagocytic activity in human macrophages through the p38 MAPK pathway
    • Vikstrom E, Magnusson KE and Pivoriunas A. The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)-L-homoserine lactone stimulates phagocytic activity in human macrophages through the p38 MAPK pathway. Microbes and infection / Institut Pasteur. 2005; 7:1512-1518.
    • (2005) Microbes and infection / Institut Pasteur. , vol.7 , pp. 1512-1518
    • Vikstrom, E.1    Magnusson, K.E.2    Pivoriunas, A.3
  • 34
    • 33846091738 scopus 로고    scopus 로고
    • The quorum-sensing molecule N-3-oxododecanoyl homoserine lactone (3OC12-HSL) enhances the host defence by activating human polymorphonuclear neutrophils (PMN)
    • Wagner C, Zimmermann S, Brenner-Weiss G, Hug F, Prior B, Obst U and Hansch GM. The quorum-sensing molecule N-3-oxododecanoyl homoserine lactone (3OC12-HSL) enhances the host defence by activating human polymorphonuclear neutrophils (PMN). Analytical and bioanalytical chemistry. 2007; 387:481-487.
    • (2007) Analytical and bioanalytical chemistry. , vol.387 , pp. 481-487
    • Wagner, C.1    Zimmermann, S.2    Brenner-Weiss, G.3    Hug, F.4    Prior, B.5    Obst, U.6    Hansch, G.M.7
  • 35
    • 84855311084 scopus 로고    scopus 로고
    • Editorial: molecular eavesdropping: phagocytic cells spy on bacterial communication
    • Hansch GM. Editorial: molecular eavesdropping: phagocytic cells spy on bacterial communication. Journal of leukocyte biology. 2012; 91:3-5.
    • (2012) Journal of leukocyte biology. , vol.91 , pp. 3-5
    • Hansch, G.M.1
  • 37
    • 84920874768 scopus 로고    scopus 로고
    • Role of the bitter taste receptor T2R38 in upper respiratory infection and chronic rhinosinusitis
    • Lee RJ and Cohen NA. Role of the bitter taste receptor T2R38 in upper respiratory infection and chronic rhinosinusitis. Current opinion in allergy and clinical immunology. 2015; 15:14-20.
    • (2015) Current opinion in allergy and clinical immunology. , vol.15 , pp. 14-20
    • Lee, R.J.1    Cohen, N.A.2
  • 38
    • 84870314938 scopus 로고    scopus 로고
    • Extraoral bitter taste receptors as mediators of off-target drug effects
    • Clark AA, Liggett SB and Munger SD. Extraoral bitter taste receptors as mediators of off-target drug effects. FASEB journal. 2012; 26:4827-4831.
    • (2012) FASEB journal. , vol.26 , pp. 4827-4831
    • Clark, A.A.1    Liggett, S.B.2    Munger, S.D.3
  • 40
    • 22844436536 scopus 로고    scopus 로고
    • A novel way to spread drug resistance in tumor cells: functional intercellular transfer of P-glycoprotein (ABCB1)
    • Ambudkar SV, Sauna ZE, Gottesman MM and Szakacs G. A novel way to spread drug resistance in tumor cells: functional intercellular transfer of P-glycoprotein (ABCB1). Trends in Pharmacological Sciences. 2005; 26:385-387.
    • (2005) Trends in Pharmacological Sciences. , vol.26 , pp. 385-387
    • Ambudkar, S.V.1    Sauna, Z.E.2    Gottesman, M.M.3    Szakacs, G.4
  • 43
    • 84921652886 scopus 로고    scopus 로고
    • Epigallocatechin gallate inhibits human tongue carcinoma cells via HK2mediated glycolysis
    • Gao F, Li M, Liu WB, Zhou ZS, Zhang R, Li JL and Zhou KC. Epigallocatechin gallate inhibits human tongue carcinoma cells via HK2mediated glycolysis. Oncology reports. 2015; 33:1533-1539.
    • (2015) Oncology reports. , vol.33 , pp. 1533-1539
    • Gao, F.1    Li, M.2    Liu, W.B.3    Zhou, Z.S.4    Zhang, R.5    Li, J.L.6    Zhou, K.C.7
  • 44
    • 34547779516 scopus 로고    scopus 로고
    • Chemopreventive effects of lupulone, a hop \(beta\)-acid, on human colon cancer-derived metastatic SW620 cells and in a rat model of colon carcinogenesis
    • Lamy V, Roussi S, Chaabi M, Gosse F, Schall N, Lobstein A and Raul F. Chemopreventive effects of lupulone, a hop \(beta\)-acid, on human colon cancer-derived metastatic SW620 cells and in a rat model of colon carcinogenesis. Carcinogenesis. 2007; 28:1575-1581.
    • (2007) Carcinogenesis. , vol.28 , pp. 1575-1581
    • Lamy, V.1    Roussi, S.2    Chaabi, M.3    Gosse, F.4    Schall, N.5    Lobstein, A.6    Raul, F.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.