Functional role of TASK-1 in the heart: Studies in TASK-1-deficient mice show prolonged cardiac repolarization and reduced heart rate variability

Basic Research in Cardiology

Volumn 106, Issue 1, 2011, Pages 75-87

  Donner, Birgit C ^a   Schullenberg, Martina ^a   Geduldig, Nora ^a   Hüning, Anja ^a   Mersmann, Jan ^b   Zacharowski, Kai ^b   Kovacevic, Alexander ^a   Decking, Ulrich ^c   Aller, Maria Isabel ^d   Schmidt, Klaus G ^a  

^a UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

^b UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^c HEINRICH HEINE UNIVERSITY   (Germany)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Action potential duration; Cardiac phenotyping; Heart rate variability; Repolarization; TASK 1 (KCNK3)

Indexed keywords

MESSENGER RNA; POTASSIUM CHANNEL; TWIK RELATED ACID SENSITIVE POTASSIUM CHANNEL; UNCLASSIFIED DRUG;

ADRENERGIC SYSTEM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ECHOCARDIOGRAPHY; EXERCISE TEST; GENOTYPE; HEART ARRHYTHMIA; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART MUSCLE POTENTIAL; HEART RATE VARIABILITY; HEART REPOLARIZATION; HISTOPATHOLOGY; IMMUNOBLOTTING; IN VITRO STUDY; IN VIVO STUDY; ISOLATED HEART; MOUSE; NONHUMAN; PHARMACOLOGIC STRESS TESTING; PHENOTYPE; PRESSORECEPTOR REFLEX; PROTEIN ANALYSIS; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; QT PROLONGATION; REAL TIME POLYMERASE CHAIN REACTION; REPERFUSION INJURY; TELEMETRY;

ACTION POTENTIALS; ANIMALS; HEART; HEART CONDUCTION SYSTEM; HEART FUNCTION TESTS; HEART RATE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDIAL REPERFUSION INJURY; MYOCARDIUM; NERVE TISSUE PROTEINS; ORGAN SIZE; PHENOTYPE; POTASSIUM CHANNELS, TANDEM PORE DOMAIN; TELEMETRY; VENTRICULAR PREMATURE COMPLEXES;

EID: 79151483334     PISSN: 03008428     EISSN: 14351803     Source Type: Journal    
DOI: 10.1007/s00395-010-0128-x     Document Type: Article

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