The cloned capsaicin receptor integrates multiple pain-producing stimuli

Neuron

Volumn 21, Issue 3, 1998, Pages 531-543

  Tominaga, Makoto ^a   Caterina, Michael J ^a   Malmberg, Annika B ^b   Rosen, Tobias A ^a   Gilbert, Heather ^b   Skinner, Kate ^b   Raumann, Brigitte E ^a   Basbaum, Allan I ^b   Julius, David ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VANILLOID RECEPTOR;

ANIMAL CELL; ARTICLE; IMMUNOCYTOCHEMISTRY; MALE; MOLECULAR CLONING; NEUROCHEMISTRY; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT; STIMULATION; TEMPERATURE; THERMAL STIMULATION;

EID: 0032169804     PISSN: 08966273     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0896-6273(00)80564-4     Document Type: Article

References (58)

1. 3H]resiniferatoxin binding by the vanilloid (capsaicin) receptor in dorsal root ganglia, spinal cord, dorsal vagal complex, sciatic and vagal nerve and urinary bladder of the rat. Life Sci. 55, 1017-1026.
2. 3H]resiniferatoxin by human and rat preoptic area, locus ceruleus, medial hypoyhalamus, reticular formation and ventral thalamus membrane preparations. Life Sci. 59, 1899-1908.
3. Bessou, P., and Perl, E.R. (1969). Response of cutaneous sensory units with unmyelinated fibers to noxious stimuli. J. Neurophysiol. 32, 1025-1043.
4. Bevan, S.J., and Docherty, R.J. (1993). Cellular mechanisms of the action of capsaicin. In Capsaicin in the Study of Pain, J. Wood, ed. (London: Academic Press), pp. 27-44.
5. Bevan, S., and Geppetti, P. (1994). Protons: small stimulants of capsaicin-sensitive sensory nerves. Trends Neurosci. 17, 509-512.
6. Bevan, S., and Szolcsanyi, J. (1990). Sensory neuron-specific actions of capsaicin: mechanisms and applications. Trends Pharmacol. Sci. 11, 330-333.
7. Bevan, S., and Yeats, J. (1991). Protons activate a cation conductance in a subpopulation of rat dorsal root ganglion neurones. J. Physiol. 433, 145-161.
8. Bevan, S., Hothi, S., Hughes, G., James, I.F., Rang, H.P., Shah, K., and Walpole, C.S.J. (1992). Capsazepine: a competitive antagonist of the sensory neuron excitant capsaicin. Br. J. Pharmacol. 107, 544-552.
9. Caterina, M.J., Schumacher, M.A., Tominaga, M., Rosen, T.A., Levine, J.D., and Julius, D. (1997). The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389, 816-824.
10. Cesare, P., and McNaughton, P. (1996). A novel heat-activated current in nociceptive neurons and its sensitization by bradykinin. Proc. Natl. Acad. Sci. USA 93, 15435-15439.
11. Devor, M., and Claman, D. (1980). Mapping and plasticity of acid phosphatase afferents in the rat dorsal horn. Brain Res. 190, 17-28.
12. Dubner, R., and Basbaum, A.I. (1994). Spinal dorsal horn plasticity following tissue or nerve injury. In Textbook of Pain, P.D. Wall and R. Melzack, eds. (Edinburgh: Churchill Livingstone), pp. 225-241.
13. Fields, H.L. (1987). Pain (New York: McGraw-Hill).
14. Fox, A.J., Urban, L., Barnes, P.J., and Dray, A. (1995). Effects of capsazepine against capsaicin-and proton-evoked excitation of single airway c-fibers and vagus nerve from the guinea pig. Neuroscience 67, 741-752.
15. Geppetti, P., Tramontana, M., Patacchini, R., Elena, D.B., Santicioli, P., and Maggi, C.A. (1990). Neurochemical evidence for the activation of the 'efferent' function of capsaicin-sensitive nerves by lowering of the pH in the guinea pig urinary bladder. Neurosci. Lett. 114, 101-106.
16. Hammond, D.L., and Ruda, M.A. (1991). Developmental alterations in nociceptive threshold, immunoreactive calcitonin gene-related peptide and substance P, and fluoride-resistant acid phosphatase in neonatally capsaicin-treated rats. J. Comp. Neurol. 372, 436-450.
17. Harlow, E., and Lane, D. (1988). Antibodies: a Laboratory Manual (Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press).
18. Hille, B. (1992). Ionic Channels of Excitable Membranes (Sunderland, MA: Sinauer Associates).
19. Hsu, S., Raine, L., and Fanger, H. (1981). A comparative study of the antiperoxidase method and an avidin-biotin complex method for studying polypeptide hormones with radioimmunoassay antibodies. Am. J. Clin. Pathol. 75, 734-738.
20. Jacobus, W., Taylor, G.J., Mollis, D.P., and Nunnally, R.L. (1977). Phosphorus nuclear magnetic resonance of perfused working rat hearts. Nature 265, 756-758.
21. Jancso, G., Kiraly, E., and Jancso-Gabor, A. (1977). Pharmacologically induced selective degeneration of chemosensitive primary sensory neurons. Nature 270, 741-743.
22. Kirschstein, T., Busselberg, D., and Treede, R.D. (1997). Coexpression of heat-evoked and capsaicin-evoked inward currents in acutely dissociated rat dorsal root ganglion neurons. Neurosci. Lett. 231, 33-36.
23. Konnerth, A., Lux, H.D., and Morad, M. (1987). Proton-induced transformation of calcium channel in chick dorsal root ganglion cells. J. Physiol. 386, 603-633.
24. Kress, M., Fetzer, S., Reeh, P.W., and Vyklicky, L. (1996). Low pH facilitates capsaicin responses in isolated sensory neurons of the rat. Neurosci. Lett. 211, 5-8.
25. Krishtal, O.A., and Pidoplichko, V.I. (1980). A receptor for protons in the nerve cell membrane. Neuroscience 5, 2325-2327.
26. LaMotte, R.H., and Campbell, J.N. (1978). Comparison of response of warm and nociceptive c-fiber afferents in monkey with human judgments of thermal pain. J. Neurophysiol. 41, 509-528.
27. Levine, J., and Taiwo, Y. (1994). Inflammatory pain. In Textbook of Pain, P.D. Wall and R. Melzack, eds. (Edinburgh: Churchill Livingstone), pp. 45-56.
28. Light, A., and Perl, E.R. (1979). Re-examination of the dorsal root projection to the spinal dorsal horn including observations on the differential termination of coarse and fine fibers. J. Comp. Neurol. 186, 117-132.
29. Liu, H., Wang, H., Sheng, M., Jan, L.Y., Jan, Y.N., and Basbaum, A.I. (1994). Evidence for presynaptic N-methyl-D-aspartate autoreceptors in the spinal cord dorsal horn. Proc. Natl. Acad. Sci. USA 91, 8383-8387.
30. Liu, L., and Simon, S.A. (1994). A rapid capsaicin-activated current in rat trigeminal ganglion neurons. Proc. Natl. Acad. Sci. USA 91, 738-741.
31. Liu, L., and Simon, S.A. (1997). Capsazepine, a vanilloid receptor antagonist inhibits nicotinic acetylcholine receptors in rat trigeminal ganglia. Neurosci. Lett. 228, 29-32.
32. Llewellyn-Smith, I.J., and Minson, J.B. (1992). Complete penetration of antibodies into vibratome sections after glutaraldehyde fixation and ethanol treatment: light and electron microscopy for neuropeptides. J. Histochem. Cytochem. 40, 1741-1749.
33. Maggi, C.A. (1992). Therapeutic potential of capsaicin-like molecules: studies in animals and humans. Life Sci. 51, 1777-1781.
34. Marfurt, C.F. (1981). The central projections of trigeminal primary afferent neurons in the cat as determined by the transganglionic transport of horseradish peroxidase. J. Comp. Neurol. 203, 785-798.
35. Martin, H.A., Basbaum, A.I., Kwiat, G.G., Goetzl, E.J., and Levine, J.D. (1987). Leukotriene and prostaglandin sensitization of cutaneous high-threshold C-and A-Delta mechanonociceptors in the hairy skin of rat hindlimbs. Neuroscience 22, 651-659.
36. Meyer, R.D., and Campbell, J.N. (1981 ). Myelinated nociceptor afferents account for the hyperalgesia that follows a burn to the hand. Science 213, 1527-1529.
37. Meyer, R.A., Campbell, J.N., and Raja, S. (1994). Peripheral neural mechanisms of nociception. In Textbook of Pain, P.D. Wall and R. Melzack, eds. (Edinburgh: Churchill Livingstone), pp. 13-44.
38. Molander, C., and Grant, G. (1985). Cutaneous projections from the rat hindlimb foot to the substantia gelatinosa of the spinal cord studied by transganglionic transport of WGA-HRP conjugate. J. Comp. Neurol. 237, 476-484.
39. Montell, C., and Rubin, G.M. (1989). Molecular characterization of the Drosophila trp locus: a putative integral membrane protein required for phototransduction. Neuron 2, 1313-1323.
40. Morgan, C., Nadelhaft, I., and de Groat, W.C. (1981). The distribution of visceral primary afferents from the pelvic nerve to Lissauer's tract and the spinal gray matter and its relationship to the sacral parasympathetic nucleus. J. Comp. Neurol. 201, 415-440.
41. Nagy, J.I., Iversen, L.L., Goedert, M., Chapman, D., and Hunt, S.P. (1983). Dose-dependent effects of capsaicin on primary sensory neurons in the neonatal rat. J. Neurosci. 3, 399-406.
42. Petersen, M., and LaMotte, R.H. (1993). Effect of protons on the inward current evoked by capsaicin in isolated dorsal root ganglion cells. Pain 54, 37-42.
43. Reichling, D.B., and Levine, J.D. (1997). Heat transduction in rat sensory neurons by calcium-dependent activation of a cation channel. Proc. Natl. Acad. Sci. USA 94, 7006-7011.
44. Ritter, S., and Dinh, T.T. (1992). Age-related changes in capsaicin-induced degeneration in rat brain. J. Comp. Neurol. 318, 103-116.
45. Santicioli, P., Bianco, E.D., Figini, M., Bevan, S., and Maggi, C.A. (1993). Effect of capsazepine on the release of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) induced by low pH, capsaicin and potassium in rat soleus muscle. Br. J. Pharmacol. 110, 609-612.
46. Snider, W.D., and McMahon, S.B. (1998). Tackling pain at the source: new ideas about nociceptors. Neuron 20, 629-632.
47. Steen, K.H., and Reeh, P.W. (1993). Sustained graded pain and hyperalgesia from harmless experimental tissue acidosis in human skin. Neurosci. Lett. 154, 113-116.
48. Steen, K.H., Reeh, P.W., Anton, F., and Handwerker, H.O. (1992). Protons selectively induce lasting excitation and sensitization to mechanical stimulation of nociceptors in rat skin, in vivo. J. Neurosci. 12, 86-95.
49. Stevens, C.R., Williams, R.B., Farrell, A.J., and Blake, D.R. (1991). Hypoxia and inflammatory synovitis: observations and speculation. Ann. Rheum. Dis. 50, 124-132.
50. Stoop, R., Surprenant, A., and North, A. (1997). Different sensitivity to pH of ATP-induced currents at four cloned P2X receptors. J. Neurophysiol. 78, 1837-1840.
51. Strichartz, G., Rando, T., and Wang, G.K. (1987). An integrated view of the molecular toxinology of sodium channel gating in excitable cells. Annu. Rev. Neurosci. 10, 237-267.
52. Szallasi, A. (1994). The vanilloid (capsaicin) receptor: receptor types and species specificity. Gen. Pharmacol. 25, 223-243.
53. Szallasi, A., Nilsson, S., Parkas-Szallasi, T., Blumberg, P.M., Hokfelt, T., and Lundberg, J.M. (1995). Vanilloid (capsaicin) receptors in the rat: distribution in the brain, regional differences in the spinal cord, axonal transport to the periphery and depletion following systemic vanilloid treatment. Brain Res. 703, 175-183.
54. Szolcsanyi, J. (1993). Actions of capsaicin on sensory neurons. In Capsaicin in the Study of Pain, J. Wood, ed. (London: Academic Press), pp. 1-26.
55. Szolcsanyi, J., Anton, F., Reeh, P.W., and Handwerker, H.O. (1988). Selective excitation by capsaicin of mechano-heat sensitive nociceptors in rat skin. Brain Res. 446, 262-268.
56. Waldmann, R., Champigny, G., Bassilana, P., Heurteaux, C., and Lazdunski, M. (1997a). A proton-gated channel involved in acid sensing. Nature 386, 173-177.
57. + channel specific for sensory neurons. J. Biol. Chem. 272, 20975-20978.
58. Winter, J., Walpole, C.S.J., Bevan, S., and James, I.F. (1993). Characterization of resiniferatoxin binding and capsaicin sensitivity in adult rat dorsal root ganglia. Neuroscience 57, 747-757.