-
1
-
-
0042844744
-
Natural products as sources of new drugs over the period 1981-2002
-
Newman DJ, Cragg GM, Snader KM (2003) Natural products as sources of new drugs over the period 1981-2002. J Nat Prod 66:1022-1037
-
(2003)
J Nat Prod
, vol.66
, pp. 1022-1037
-
-
Newman, D.J.1
Cragg, G.M.2
Snader, K.M.3
-
2
-
-
27144547510
-
Chemistry The renaissance of natural products as drug candidates
-
Paterson I, Anderson EA (2005) Chemistry. The renaissance of natural products as drug candidates. Science 310:451-453
-
(2005)
Science
, vol.310
, pp. 451-453
-
-
Paterson, I.1
Anderson, E.A.2
-
3
-
-
0041708061
-
TRPC5 is a regulator of hippocampal neurite length and growth cone morphology
-
Greka A, Navarro B, Oancea E, Duggan A, Clapham DE (2003) TRPC5 is a regulator of hippocampal neurite length and growth cone morphology. Nat Neurosci 6:837-845
-
(2003)
Nat Neurosci
, vol.6
, pp. 837-845
-
-
Greka, A.1
Navarro, B.2
Oancea, E.3
Duggan, A.4
Clapham, D.E.5
-
4
-
-
26444591482
-
TRP channels: A TR(I)P through a world of multifunctional cation channels
-
Nilius B, Voets T (2005) TRP channels: A TR(I)P through a world of multifunctional cation channels. Pflugers Arch 451:1-10
-
(2005)
Pflugers Arch
, vol.451
, pp. 1-10
-
-
Nilius, B.1
Voets, T.2
-
5
-
-
0347504835
-
TRP channels as cellular sensors
-
Clapham DE (2003) TRP channels as cellular sensors. Nature 426:517-524
-
(2003)
Nature
, vol.426
, pp. 517-524
-
-
Clapham, D.E.1
-
7
-
-
0030777012
-
The capsaicin receptor: A heat-activated ion channel in the pain pathway
-
Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D (1997) The capsaicin receptor: A heat-activated ion channel in the pain pathway. Nature 389:816-824
-
(1997)
Nature
, vol.389
, pp. 816-824
-
-
Caterina, M.J.1
Schumacher, M.A.2
Tominaga, M.3
Rosen, T.A.4
Levine, J.D.5
Julius, D.6
-
8
-
-
0032169804
-
The cloned capsaicin receptor integrates multiple pain-producing stimuli
-
Tominaga M, Caterina MJ, Malmberg AB, Rosen TA, Gilbert H, Skinner K, Raumann BE, Basbaum AI, Julius D (1998) The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 21:531-543
-
(1998)
Neuron
, vol.21
, pp. 531-543
-
-
Tominaga, M.1
Caterina, M.J.2
Malmberg, A.B.3
Rosen, T.A.4
Gilbert, H.5
Skinner, K.6
Raumann, B.E.7
Basbaum, A.I.8
Julius, D.9
-
10
-
-
4644266613
-
The role of the vanilloid (capsaicin) receptor (TRPV1) in physiology and pathology
-
Nagy I, Santha P, Jancso G, Urban L (2004) The role of the vanilloid (capsaicin) receptor (TRPV1) in physiology and pathology. Eur J Pharmacol 500:351-369
-
(2004)
Eur J Pharmacol
, vol.500
, pp. 351-369
-
-
Nagy, I.1
Santha, P.2
Jancso, G.3
Urban, L.4
-
11
-
-
0034638450
-
Cannabinoid 1 receptors are expressed in nociceptive primary sensory neurons
-
Ahluwalia J, Urban L, Capogna M, Bevan S, Nagy I (2000) Cannabinoid 1 receptors are expressed in nociceptive primary sensory neurons. Neuroscience 100:685-688
-
(2000)
Neuroscience
, vol.100
, pp. 685-688
-
-
Ahluwalia, J.1
Urban, L.2
Capogna, M.3
Bevan, S.4
Nagy, I.5
-
12
-
-
1642355120
-
Ca2+/calmodulin-dependent protein kinase II in the rat cranial sensory ganglia
-
Ichikawa H, Gouty S, Regalia J, Helke CJ, Sugimoto T (2004) Ca2+/calmodulin-dependent protein kinase II in the rat cranial sensory ganglia. Brain Res 1005:36-43
-
(2004)
Brain Res
, vol.1005
, pp. 36-43
-
-
Ichikawa, H.1
Gouty, S.2
Regalia, J.3
Helke, C.J.4
Sugimoto, T.5
-
13
-
-
0033103354
-
Differential expression of themRNA for the vanilloid receptor subtype 1 in cells of the adult rat dorsal root and nodose ganglia and its downregulation by axotomy
-
Michael GJ, Priestley JV (1999) Differential expression of themRNA for the vanilloid receptor subtype 1 in cells of the adult rat dorsal root and nodose ganglia and its downregulation by axotomy. J Neurosci 19:1844-1854
-
(1999)
J Neurosci
, vol.19
, pp. 1844-1854
-
-
Michael, G.J.1
Priestley, J.V.2
-
14
-
-
0032876069
-
The cloned rat vanilloid receptor VR1 mediates both R-type binding and C-type calcium response in dorsal root ganglion neurons
-
Szallasi A, Blumberg PM, Annicelli LL, Krause JE, Cortright DN (1999) The cloned rat vanilloid receptor VR1 mediates both R-type binding and C-type calcium response in dorsal root ganglion neurons. Mol Pharmacol 56:581-587
-
(1999)
Mol Pharmacol
, vol.56
, pp. 581-587
-
-
Szallasi, A.1
Blumberg, P.M.2
Annicelli, L.L.3
Krause, J.E.4
Cortright, D.N.5
-
15
-
-
0032967640
-
Immunocytochemical localization of the vanilloid receptor 1 (VR1): Relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites
-
Guo A, Vulchanova L, Wang J, Li X, Elde R (1999) Immunocytochemical localization of the vanilloid receptor 1 (VR1): Relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites. Eur J Neurosci 11:946-958
-
(1999)
Eur J Neurosci
, vol.11
, pp. 946-958
-
-
Guo, A.1
Vulchanova, L.2
Wang, J.3
Li, X.4
Elde, R.5
-
16
-
-
12844286900
-
Early painful diabetic neuropathy is associated with differential changes in the expression and function of vanilloid receptor 1
-
Hong S, Wiley J (2005) Early painful diabetic neuropathy is associated with differential changes in the expression and function of vanilloid receptor 1. J Biol Chem 280:618-627
-
(2005)
J Biol Chem
, vol.280
, pp. 618-627
-
-
Hong, S.1
Wiley, J.2
-
18
-
-
34047118624
-
The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation
-
Gavva NR, Bannon AW, Surapaneni S, Hovland DN Jr, Lehto SG, Gore A, Juan T, Deng H, Han B, Klionsky L, Kuang R, Le A, Tamir R, Wang J, Youngblood B, Zhu D, Norman MH, Magal E, Treanor JJ, Louis JC (2007) The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation. J Neurosci 27:3366-3374
-
(2007)
J Neurosci
, vol.27
, pp. 3366-3374
-
-
Gavva, N.R.1
Bannon, A.W.2
Surapaneni, S.3
Hovland Jr., D.N.4
Lehto, S.G.5
Gore, A.6
Juan, T.7
Deng, H.8
Han, B.9
Klionsky, L.10
Kuang, R.11
Le A Tamir, R.12
Wang, J.13
Youngblood, B.14
Zhu, D.15
Norman, M.H.16
Magal, E.17
Treanor, J.J.18
Louis, J.C.19
-
19
-
-
0035818575
-
Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells
-
Birder LA, Kanai AJ, de GroatWC, Kiss S, Nealen ML, Burke NE, Dineley KE,Watkins S, Reynolds IJ, Caterina MJ (2001) Vanilloid receptor expression suggests a sensory role for urinary bladder epithelial cells. Proc Natl Acad Sci USA 98:13396-13401
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 13396-13401
-
-
Birder, L.A.1
Kanai, A.J.2
De Groat, W.C.3
Kiss, S.4
Nealen, M.L.5
Burke, N.E.6
Dineley, K.E.7
Watkins, S.8
Reynolds, I.J.9
Caterina, M.J.10
-
20
-
-
0034809957
-
Transient expression of vanilloid receptor subtype 1 in rat cardiomyocytes during development
-
Dvorakova M, KummerW(2001) Transient expression of vanilloid receptor subtype 1 in rat cardiomyocytes during development. Histochem Cell Biol 116:223-225
-
(2001)
Histochem Cell Biol
, vol.116
, pp. 223-225
-
-
Dvorakova, M.1
Kummer, W.2
-
21
-
-
0032079025
-
Specific vanilloid responses in C6 rat glioma cells
-
Biro T, Brodie C, Modarres S, Lewin NE, Acs P, Blumberg PM (1998) Specific vanilloid responses in C6 rat glioma cells. Brain Res Mol Brain Res 56:89-98
-
(1998)
Brain Res Mol Brain Res
, vol.56
, pp. 89-98
-
-
Biro, T.1
Brodie, C.2
Modarres, S.3
Lewin, N.E.4
Acs, P.5
Blumberg, P.M.6
-
22
-
-
0344884588
-
Characterization of functional vanilloid receptors expressed by mast cells
-
Biro T, Maurer M, Modarres S, Lewin NE, Brodie C, Acs G, Acs P, Paus R, Blumberg PM (1998) Characterization of functional vanilloid receptors expressed by mast cells. Blood 91:1332-1340
-
(1998)
Blood
, vol.91
, pp. 1332-1340
-
-
Biro, T.1
Maurer, M.2
Modarres, S.3
Lewin, N.E.4
Brodie, C.5
Acs, G.6
Acs, P.7
Paus, R.8
Blumberg, P.M.9
-
23
-
-
24944434348
-
Transient receptor potential channels in the inner ear: Presence of transient receptor potential channel subfamily 1 and 4 in the guinea pig inner ear
-
Takumida M, Kubo N, Ohtani M, Suzuka Y, Anniko M (2005) Transient receptor potential channels in the inner ear: Presence of transient receptor potential channel subfamily 1 and 4 in the guinea pig inner ear. Acta Otolaryngol 125:929-934
-
(2005)
Acta Otolaryngol
, vol.125
, pp. 929-934
-
-
Takumida, M.1
Kubo, N.2
Ohtani, M.3
Suzuka, Y.4
Anniko, M.5
-
24
-
-
0037486951
-
Vanilloid receptors in hearing: Altered cochlear sensitivity by vanilloids and expression of TRPV1 in the organ of corti
-
Zheng J, Dai C, Steyger PS, Kim Y, Vass Z, Ren T, Nuttall AL (2003) Vanilloid receptors in hearing: Altered cochlear sensitivity by vanilloids and expression of TRPV1 in the organ of corti. J Neurophysiol 90:444-455
-
(2003)
J Neurophysiol
, vol.90
, pp. 444-455
-
-
Zheng, J.1
Dai, C.2
Steyger, P.S.3
Kim, Y.4
Vass, Z.5
Ren, T.6
Nuttall, A.L.7
-
25
-
-
0036085872
-
Functional vanilloid receptors in cultured normal human epidermal keratinocytes
-
Inoue K, Koizumi S, Fuziwara S, Denda S, Denda M (2002) Functional vanilloid receptors in cultured normal human epidermal keratinocytes. Biochem Biophys Res Commun 291: 124-129
-
(2002)
Biochem Biophys Res Commun
, vol.291
, pp. 124-129
-
-
Inoue, K.1
Koizumi, S.2
Fuziwara, S.3
Denda, S.4
Denda, M.5
-
26
-
-
0035940785
-
The distribution and regulation of vanilloid receptor VR1 and VR1 5- splice variant RNA expression in rat
-
Sanchez J, Krause J, Cortright D (2001) The distribution and regulation of vanilloid receptor VR1 and VR1 5- splice variant RNA expression in rat. Neuroscience 107:373-381
-
(2001)
Neuroscience
, vol.107
, pp. 373-381
-
-
Sanchez, J.1
Krause, J.2
Cortright, D.3
-
27
-
-
0035724244
-
Capsaicin receptor VR1 and ATP-gated ion channel P2X3 in human urinary bladder
-
Yiangou Y, Facer P, Ford A, Brady C, Wiseman O, Fowler C et al (2001) Capsaicin receptor VR1 and ATP-gated ion channel P2X3 in human urinary bladder. BJU Int 87:774-779
-
(2001)
BJU Int
, vol.87
, pp. 774-779
-
-
Yiangou, Y.1
Facer, P.2
Ford, A.3
Brady, C.4
Wiseman, O.5
Fowler, C.6
-
28
-
-
0037154961
-
Vanilloid receptor 1 expression in the rat urinary tract
-
Avelino A, Cruz C, Nagy I, Cruz F (2002) Vanilloid receptor 1 expression in the rat urinary tract. Neuroscience 109:787-798
-
(2002)
Neuroscience
, vol.109
, pp. 787-798
-
-
Avelino, A.1
Cruz, C.2
Nagy, I.3
Cruz, F.4
-
29
-
-
0041880703
-
Arck Pc KBFFA: Expression of substance P and vanilloid receptor (VR1) in trigeminal sensory neurons projecting to the mouse nasal mucosa
-
Dinh QT, Groneberg DA,Mingomataj E, Peiser C, HepptW, Dinh S (2003) Arck Pc KBFFA: Expression of substance P and vanilloid receptor (VR1) in trigeminal sensory neurons projecting to the mouse nasal mucosa. Neuropeptides 37:245-250
-
(2003)
Neuropeptides
, vol.37
, pp. 245-250
-
-
Dinh, Q.T.1
Groneberg, D.A.2
Mingomataj, E.3
Peiser, C.4
Heppt, W.5
Dinh, S.6
-
30
-
-
0043233156
-
Interstitial cells in the human prostate: A new therapeutic target?
-
Van der Aa F, Roskams T, Blyweert W, De Ridder D (2003) Interstitial cells in the human prostate: A new therapeutic target?. Prostate 56:250-255
-
(2003)
Prostate
, vol.56
, pp. 250-255
-
-
Van Der Aa, F.1
Roskams, T.2
Blyweert, W.3
De Ridder, D.4
-
31
-
-
0041691167
-
Distribution of the vanilloid receptor (VR1) in the gastrointestinal tract
-
Ward S, Bayguinov J, Won K, Grundy D, Berthoud H (2003) Distribution of the vanilloid receptor (VR1) in the gastrointestinal tract. J Comp Neurol 465:121-135
-
(2003)
J Comp Neurol
, vol.465
, pp. 121-135
-
-
Ward, S.1
Bayguinov, J.2
Won, K.3
Grundy, D.4
Berthoud, H.5
-
32
-
-
0141476269
-
Cardiac vanilloid receptor 1-expressing afferent nerves and their role in the cardiogenic sympathetic reflex in rats
-
Zahner MR, Li DP, Chen SR, Pan HL (2003) Cardiac vanilloid receptor 1-expressing afferent nerves and their role in the cardiogenic sympathetic reflex in rats. J Physiol 551: 515-523
-
(2003)
J Physiol
, vol.551
, pp. 515-523
-
-
Zahner, M.R.1
Li, D.P.2
Chen, S.R.3
Pan, H.L.4
-
33
-
-
0032970173
-
Vanilloid (Capsaicin) receptors and mechanisms
-
Szallasi A, Blumberg PM (1999) Vanilloid (Capsaicin) receptors and mechanisms. Pharmacol Rev 51:159-212
-
(1999)
Pharmacol Rev
, vol.51
, pp. 159-212
-
-
Szallasi, A.1
Blumberg, P.M.2
-
34
-
-
0027403631
-
Capsaicin: Identification, nomenclature, and pharmacotherapy
-
Cordell GA, Araujo OE (1993) Capsaicin: Identification, nomenclature, and pharmacotherapy. Ann Pharmacother 27:330-336
-
(1993)
Ann Pharmacother
, vol.27
, pp. 330-336
-
-
Cordell, G.A.1
Araujo, O.E.2
-
35
-
-
0001063417
-
-
Academic Press, Orlando, FL
-
Suzuki T, Iwai K (1984) Constituents of red pepper species: Chemistry, biochemistry, pharmacology, and food science of the pungent principle of capsicum species. Academic Press, Orlando, FL
-
(1984)
Constituents of Red Pepper Species: Chemistry, Biochemistry, Pharmacology, and Food Science of the Pungent Principle of Capsicum Species
-
-
Suzuki, T.1
Iwai, K.2
-
36
-
-
33644868454
-
Adenylyl cyclase type 5 (AC5) is an essential mediator of morphine action
-
Kim KS, Lee KW, Im JY, Yoo JY, Kim SW, Lee JK, Nestler EJ, Han PL (2006) Adenylyl cyclase type 5 (AC5) is an essential mediator of morphine action. Proc Natl Acad Sci USA 103:3908-3913
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 3908-3913
-
-
Kim, K.S.1
Lee, K.W.2
Im, J.Y.3
Yoo, J.Y.4
Kim, S.W.5
Lee, J.K.6
Nestler, E.J.7
Han, P.L.8
-
37
-
-
0037581663
-
Capsaicin binds to the intracellular domain of the capsaicin-activated ion channel
-
Jung J, Hwang SW, Kwak J, Lee SY, Kang CJ, Kim WB, Kim DOU (1999) Capsaicin binds to the intracellular domain of the capsaicin-activated ion channel. J Neurosci 19: 529-538
-
(1999)
J Neurosci
, vol.19
, pp. 529-538
-
-
Jung, J.1
Hwang, S.W.2
Kwak, J.3
Lee, S.Y.4
Kang, C.J.5
Kim, W.B.6
Kim, D.O.U.7
-
38
-
-
0037113918
-
Agonist recognition sites in the cytosolic tails of vanilloid receptor 1
-
Jung J, Lee SY, Hwang SW, Cho H, Shin J, Kang YS, Kim SOU (2002) Agonist recognition sites in the cytosolic tails of vanilloid receptor 1. J Biol Chem 277:44448-44454
-
(2002)
J Biol Chem
, vol.277
, pp. 44448-44454
-
-
Jung, J.1
Lee, S.Y.2
Hwang, S.W.3
Cho, H.4
Shin, J.5
Kang, Y.S.6
Kim, S.O.U.7
-
39
-
-
0036183319
-
Molecular basis for species-specific sensitivity to "hot" chili peppers
-
Jordt SE, Julius D (2002) Molecular basis for species-specific sensitivity to "hot" chili peppers. Cell 108:421-430
-
(2002)
Cell
, vol.108
, pp. 421-430
-
-
Jordt, S.E.1
Julius, D.2
-
40
-
-
0004906771
-
Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances
-
Hwang SW, Cho H, Kwak J, Lee SY, Kang CJ, Jung J, Cho S, Min KH, Suh YG, Kim D, Oh U (2000) Direct activation of capsaicin receptors by products of lipoxygenases: Endogenous capsaicin-like substances. Proc Natl Acad Sci USA 97:6155-6160
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 6155-6160
-
-
Hwang, S.W.1
Cho, H.2
Kwak, J.3
Lee, S.Y.4
Kang, C.J.5
Jung, J.6
Cho, S.7
Min, K.H.8
Suh, Y.G.9
Kim, D.10
Oh, U.11
-
41
-
-
0033788731
-
Lowthreshold heat response antagonized by capsazepine in chick sensory neurons, which are capsaicin-insensitive
-
Marin-Burgin A, Reppenhagen S, Klusch A, Wendland JR, Petersen M (2000) Lowthreshold heat response antagonized by capsazepine in chick sensory neurons, which are capsaicin-insensitive. Eur J Neurosci 12:3560-3566
-
(2000)
Eur J Neurosci
, vol.12
, pp. 3560-3566
-
-
Marin-Burgin, A.1
Reppenhagen, S.2
Klusch, A.3
Wendland, J.R.4
Petersen, M.5
-
42
-
-
0242367472
-
Activation of vanilloid receptor 1 (VR1) by eugenol
-
Yang BH, Piao ZG, Kim YB, Lee CH, Lee JK, Park K, Kim JS, Oh SB (2003) Activation of vanilloid receptor 1 (VR1) by eugenol. J Dent Res 82:781-785
-
(2003)
J Dent Res
, vol.82
, pp. 781-785
-
-
Yang, B.H.1
Piao, Z.G.2
Kim, Y.B.3
Lee, C.H.4
Lee, J.K.5
Park, K.6
Kim, J.S.7
Oh, S.B.8
-
43
-
-
33745742247
-
Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels
-
Xu H, Delling M, Jun JC, Clapham DE (2006) Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels. Nat Neurosci 9:628-635
-
(2006)
Nat Neurosci
, vol.9
, pp. 628-635
-
-
Xu, H.1
Delling, M.2
Jun, J.C.3
Clapham, D.E.4
-
44
-
-
1842475312
-
Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin
-
Bandell M, Story GM, Hwang SW, Viswanath V, Eid SR, Petrus MJ, Earley TJ, Patapoutian A (2004) Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron 41:849-857
-
(2004)
Neuron
, vol.41
, pp. 849-857
-
-
Bandell, M.1
Story, G.M.2
Hwang, S.W.3
Viswanath, V.4
Eid, S.R.5
Petrus, M.J.6
Earley, T.J.7
Patapoutian, A.8
-
45
-
-
27244459955
-
Eugenol inhibits calcium currents in dental afferent neurons
-
Lee MH, Yeon KY, Park CK, Li HY, Fang Z, Kim MS, Choi SY, Lee SJ, Lee S, Park K, Lee JH, Kim JS, Oh SB (2005) Eugenol inhibits calcium currents in dental afferent neurons. J Dent Res 84:848-851
-
(2005)
J Dent Res
, vol.84
, pp. 848-851
-
-
Lee, M.H.1
Yeon, K.Y.2
Park, C.K.3
Li, H.Y.4
Fang, Z.5
Kim, M.S.6
Choi, S.Y.7
Lee, S.J.8
Lee, S.9
Park, K.10
Lee, J.H.11
Kim, J.S.12
Oh, S.B.13
-
46
-
-
33750070670
-
Eugenol inhibits sodium currents in dental afferent neurons
-
Park CK, Li HY, Yeon KY, Jung SJ, Choi SY, Lee SJ, Lee S, Park K, Kim JS, Oh SB (2006) Eugenol inhibits sodium currents in dental afferent neurons. J Dent Res 85:900-904
-
(2006)
J Dent Res
, vol.85
, pp. 900-904
-
-
Park, C.K.1
Li, H.Y.2
Yeon, K.Y.3
Jung, S.J.4
Choi, S.Y.5
Lee, S.J.6
Lee, S.7
Park, K.8
Kim, J.S.9
Oh, S.B.10
-
47
-
-
39149140380
-
Modulation of CaV2.3 calcium channel currents by eugenol
-
Chung G, Rhee JN, Jung SJ, Kim JS, Oh SB (2008) Modulation of CaV2.3 calcium channel currents by eugenol. J Dent Res 87:137-141
-
(2008)
J Dent Res
, vol.87
, pp. 137-141
-
-
Chung, G.1
Rhee, J.N.2
Jung, S.J.3
Kim, J.S.4
Oh, S.B.5
-
48
-
-
58249097232
-
Eugenol inhibits ATP-induced P2X currents in trigeminal ganglion neurons
-
Li HY, Lee BK, Kim JS, Jung SJ, Oh SB (2008) Eugenol Inhibits ATP-induced P2X Currents in Trigeminal Ganglion Neurons. Korean J Physiol Pharmacol 12:315-321
-
(2008)
Korean J Physiol Pharmacol
, vol.12
, pp. 315-321
-
-
Li, H.Y.1
Lee, B.K.2
Kim, J.S.3
Jung, S.J.4
Oh, S.B.5
-
49
-
-
0031110885
-
The selective capsaicin antagonist capsazepine abolishes the antinociceptive action of eugenol and guaiacol
-
Ohkubo T, Shibata M (1997) The selective capsaicin antagonist capsazepine abolishes the antinociceptive action of eugenol and guaiacol. J Dent Res 76:848-851
-
(1997)
J Dent Res
, vol.76
, pp. 848-851
-
-
Ohkubo, T.1
Shibata, M.2
-
50
-
-
0029763505
-
Similarities and differences in the currents activated by capsaicin, piperine, and zingerone in rat trigeminal ganglion cells
-
Liu L, Simon SA (1996) Similarities and differences in the currents activated by capsaicin, piperine, and zingerone in rat trigeminal ganglion cells. J Neurophysiol 76:1858-1869
-
(1996)
J Neurophysiol
, vol.76
, pp. 1858-1869
-
-
Liu, L.1
Simon, S.A.2
-
51
-
-
17144418518
-
Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1)
-
McNamara FN, Randall A, Gunthorpe MJ (2005) Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1). Br J Pharmacol 144:781-790
-
(2005)
Br J Pharmacol
, vol.144
, pp. 781-790
-
-
McNamara, F.N.1
Randall, A.2
Gunthorpe, M.J.3
-
52
-
-
0036070626
-
Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4
-
Bhardwaj RK, Glaeser H, Becquemont L, Klotz U, Gupta SK, FrommMF (2002) Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4. J Pharmacol Exp Ther 302:645-650
-
(2002)
J Pharmacol Exp Ther
, vol.302
, pp. 645-650
-
-
Bhardwaj, R.K.1
Glaeser, H.2
Becquemont, L.3
Klotz, U.4
Gupta, S.K.5
Fromm, M.F.6
-
53
-
-
33845328489
-
A nonpungent component of steamed ginger - [10]-shogaol - increases adrenaline secretion via the activation of TRPV1
-
Iwasaki Y, Morita A, Iwasawa T, Kobata K, Sekiwa Y, Morimitsu Y, Kubota K, Watanabe T (2006) A nonpungent component of steamed ginger - [10]-shogaol - increases adrenaline secretion via the activation of TRPV1. Nutr Neurosci 9:169-178
-
(2006)
Nutr Neurosci
, vol.9
, pp. 169-178
-
-
Iwasaki, Y.1
Morita, A.2
Iwasawa, T.3
Kobata, K.4
Sekiwa, Y.5
Morimitsu, Y.6
Kubota, K.7
Watanabe, T.8
-
54
-
-
0642308614
-
Use of a fluorescent imaging plate reader - based calcium assay to assess pharmacological differences between the human and rat vanilloid receptor
-
Witte DG, Cassar SC, Masters JN, Esbenshade T, Hancock AA (2002) Use of a fluorescent imaging plate reader - based calcium assay to assess pharmacological differences between the human and rat vanilloid receptor. J Biomol Screen 7:466-475
-
(2002)
J Biomol Screen
, vol.7
, pp. 466-475
-
-
Witte, D.G.1
Cassar, S.C.2
Masters, J.N.3
Esbenshade, T.4
Hancock, A.A.5
-
55
-
-
0036856241
-
Gingerols: A novel class of vanilloid receptor (VR1) agonists
-
Dedov VN, Tran VH, Duke CC, Connor M, Christie MJ, Mandadi S, Roufogalis BD (2002) Gingerols: A novel class of vanilloid receptor (VR1) agonists. Br J Pharmacol 137:793-798
-
(2002)
Br J Pharmacol
, vol.137
, pp. 793-798
-
-
Dedov, V.N.1
Tran, V.H.2
Duke, C.C.3
Connor, M.4
Christie, M.J.5
Mandadi, S.6
Roufogalis, B.D.7
-
56
-
-
33646152536
-
Modulation of human TRPV1 receptor activity by extracellular protons and host cell expression system
-
Bianchi BR, Lee CH, Jarvis MF, El Kouhen R, Moreland RB, Faltynek CR, Puttfarcken PS (2006) Modulation of human TRPV1 receptor activity by extracellular protons and host cell expression system. Eur J Pharmacol 537:20-30
-
(2006)
Eur J Pharmacol
, vol.537
, pp. 20-30
-
-
Bianchi, B.R.1
Lee, C.H.2
Jarvis, M.F.3
El Kouhen, R.4
Moreland, R.B.5
Faltynek, C.R.6
Puttfarcken, P.S.7
-
57
-
-
70350338210
-
Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels
-
Riera CE, Menozzi-Smarrito C, Affolter M, Michlig S, Munari C, Robert F, Vogel H, Simon SA, le Coutre J (2009) Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels. Br J Pharmacol 157: 1398-1409
-
(2009)
Br J Pharmacol
, vol.157
, pp. 1398-1409
-
-
Riera, C.E.1
Menozzi-Smarrito, C.2
Affolter, M.3
Michlig, S.4
Munari, C.5
Robert, F.6
Vogel, H.7
Simon, S.A.8
Le Coutre, J.9
-
58
-
-
34447506660
-
Brun P: A potential role for the vanilloid receptor TRPV1 in the therapeutic effect of curcumin in dinitrobenzene sulphonic acid-induced colitis in mice
-
Martelli L, Ragazzi E (2007) di Mario F,MartelliM, Castagliuolo I, Dal MaschioM, Palu G, Machietto M, Scorzeto M, Vassanelli S, Brun P: A potential role for the vanilloid receptor TRPV1 in the therapeutic effect of curcumin in dinitrobenzene sulphonic acid-induced colitis in mice. Neurogastroenterol Motil 19:668-674
-
(2007)
Neurogastroenterol Motil
, vol.19
, pp. 668-674
-
-
Martelli, L.1
Ragazzi, E.2
Di Mario, F.3
Martelli, M.4
Castagliuolo, I.5
Dal Maschio, M.6
Palu, G.7
Machietto, M.8
Scorzeto, M.9
Vassanelli, S.10
-
59
-
-
75649138334
-
Curcumin produces an antihyperalgesic effect via antagonism of TRPV1
-
Yeon KY, Kim SA, Kim YH, Lee MK, Ahn DK, Kim HJ, Jung SJ, Oh SB (2010) Curcumin produces an antihyperalgesic effect via antagonism of TRPV1. J Dent Res 89:170-174
-
(2010)
J Dent Res
, vol.89
, pp. 170-174
-
-
Yeon, K.Y.1
Kim, S.A.2
Kim, Y.H.3
Lee, M.K.4
Ahn, D.K.5
Kim, H.J.6
Jung, S.J.7
Oh, S.B.8
-
60
-
-
0024382437
-
Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper
-
Szallasi A, Blumberg PM (1989) Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper. Neuroscience 30: 515-520
-
(1989)
Neuroscience
, vol.30
, pp. 515-520
-
-
Szallasi, A.1
Blumberg, P.M.2
-
61
-
-
0025854393
-
Characterization of vanilloid receptors in the dorsal horn of pig spinal cord
-
Szallasi A, Blumberg PM (1991) Characterization of vanilloid receptors in the dorsal horn of pig spinal cord. Brain Res 547:335-338
-
(1991)
Brain Res
, vol.547
, pp. 335-338
-
-
Szallasi, A.1
Blumberg, P.M.2
-
62
-
-
0025202606
-
Resiniferatoxin and its analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor
-
Szallasi A, Blumberg PM (1990) Resiniferatoxin and its analogs provide novel insights into the pharmacology of the vanilloid (capsaicin) receptor. Life Sci 47:1399-1408
-
(1990)
Life Sci
, vol.47
, pp. 1399-1408
-
-
Szallasi, A.1
Blumberg, P.M.2
-
63
-
-
33845777090
-
Structure-activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): The homovanillyl moiety
-
Appendino G, Ech-Chahad A, Minassi A, Bacchiega S, De Petrocellis L, Di Marzo V (2007) Structure-activity relationships of the ultrapotent vanilloid resiniferatoxin (RTX): The homovanillyl moiety. Bioorg Med Chem Lett 17:132-135
-
(2007)
Bioorg Med Chem Lett
, vol.17
, pp. 132-135
-
-
Appendino, G.1
Ech-Chahad, A.2
Minassi, A.3
Bacchiega, S.4
De Petrocellis, L.5
Di Marzo, V.6
-
64
-
-
58549087355
-
Non-vanillyl resiniferatoxin analogues as potent and metabolically stable transient receptor potential vanilloid 1 agonists
-
Choi HK, Choi S, Lee Y, Kang DW, Ryu H, Maeng HJ, Chung SJ, Pavlyukovets VA, Pearce LV, Toth A, Tran R, Wang Y, Morgan MA, Blumberg PM, Lee J (2009) Non-vanillyl resiniferatoxin analogues as potent and metabolically stable transient receptor potential vanilloid 1 agonists. Bioorg Med Chem 17:690-698
-
(2009)
Bioorg Med Chem
, vol.17
, pp. 690-698
-
-
Choi, H.K.1
Choi, S.2
Lee, Y.3
Kang, D.W.4
Ryu, H.5
Maeng, H.J.6
Chung, S.J.7
Pavlyukovets, V.A.8
Pearce, L.V.9
Toth, A.10
Tran, R.11
Wang, Y.12
Morgan, M.A.13
Blumberg, P.M.14
Lee, J.15
-
65
-
-
0030024173
-
Distinct structure-activity relations for stimulation of 45Ca uptake and for high affinity binding in cultured rat dorsal root ganglion neurons and dorsal root ganglion membranes
-
Acs G, Lee J, Marquez VE, Blumberg PM (1996) Distinct structure-activity relations for stimulation of 45Ca uptake and for high affinity binding in cultured rat dorsal root ganglion neurons and dorsal root ganglion membranes. Brain Res Mol Brain Res 35:173-182
-
(1996)
Brain Res Mol Brain Res
, vol.35
, pp. 173-182
-
-
Acs, G.1
Lee, J.2
Marquez, V.E.3
Blumberg, P.M.4
-
66
-
-
0029340192
-
Structure-activity relationships for unsaturated dialdehydes. 10. The generation of bioactive products by autoxidation of isovelleral and merulidial
-
Jonassohn M, Anke H, Morales P, Sterner O (1995) Structure-activity relationships for unsaturated dialdehydes. 10. The generation of bioactive products by autoxidation of isovelleral and merulidial. Acta Chem Scand 49:530-535
-
(1995)
Acta Chem Scand
, vol.49
, pp. 530-535
-
-
Jonassohn, M.1
Anke, H.2
Morales, P.3
Sterner, O.4
-
67
-
-
0029833970
-
The stimulation of capsaicin-sensitive neurones in a vanilloid receptor-mediated fashion by pungent terpenoids possessing an unsaturated 1,4-dialdehyde moiety
-
Szallasi A, Jonassohn M, Acs G, Biro T, Acs P, Blumberg PM, Sterner O (1996) The stimulation of capsaicin-sensitive neurones in a vanilloid receptor-mediated fashion by pungent terpenoids possessing an unsaturated 1,4-dialdehyde moiety. Br J Pharmacol 119:283-290
-
(1996)
Br J Pharmacol
, vol.119
, pp. 283-290
-
-
Szallasi, A.1
Jonassohn, M.2
Acs, G.3
Biro, T.4
Acs, P.5
Blumberg, P.M.6
Sterner, O.7
-
68
-
-
0032575618
-
Dialdehyde sesquiterpenes and other terpenoids as vanilloids
-
Szallasi A, Biro T, Modarres S, Garlaschelli L, Petersen M, Klusch A, Vidari G, Jonassohn M, De Rosa S, Sterner O, Blumberg PM, Krause JE (1998) Dialdehyde sesquiterpenes and other terpenoids as vanilloids. Eur J Pharmacol 356:81-89
-
(1998)
Eur J Pharmacol
, vol.356
, pp. 81-89
-
-
Szallasi, A.1
Biro, T.2
Modarres, S.3
Garlaschelli, L.4
Petersen, M.5
Klusch, A.6
Vidari, G.7
Jonassohn, M.8
De Rosa, S.9
Sterner, O.10
Blumberg, P.M.11
Krause, J.E.12
-
69
-
-
0032721391
-
Novel natural vanilloid receptor agonists: New therapeutic targets for drug development
-
Sterner O, Szallasi A (1999) Novel natural vanilloid receptor agonists: New therapeutic targets for drug development. Trends Pharmacol Sci 20:459-465
-
(1999)
Trends Pharmacol Sci
, vol.20
, pp. 459-465
-
-
Sterner, O.1
Szallasi, A.2
-
70
-
-
67349176347
-
Miogadial and miogatrial with alpha,betaunsaturated 1,4-dialdehyde moieties - novel and potent TRPA1 agonists
-
Iwasaki Y, Tanabe M, Kayama Y, Abe M, Kashio M, Koizumi K, Okumura Y, Morimitsu Y, Tominaga M, Ozawa Y, Watanabe T (2009) Miogadial and miogatrial with alpha,betaunsaturated 1,4-dialdehyde moieties - novel and potent TRPA1 agonists. Life Sci 85:60-69
-
(2009)
Life Sci
, vol.85
, pp. 60-69
-
-
Iwasaki, Y.1
Tanabe, M.2
Kayama, Y.3
Abe, M.4
Kashio, M.5
Koizumi, K.6
Okumura, Y.7
Morimitsu, Y.8
Tominaga, M.9
Ozawa, Y.10
Watanabe, T.11
-
71
-
-
0037213765
-
Pharmacology of vanilloids at recombinant and endogenous rat vanilloid receptors
-
Ralevic V, Jerman JC, Brough SJ, Davis JB, Egerton J, Smart D (2003) Pharmacology of vanilloids at recombinant and endogenous rat vanilloid receptors. Biochem Pharmacol 65:143-151
-
(2003)
Biochem Pharmacol
, vol.65
, pp. 143-151
-
-
Ralevic, V.1
Jerman, J.C.2
Brough, S.J.3
Davis, J.B.4
Egerton, J.5
Smart, D.6
-
72
-
-
0033001482
-
A non-pungent triprenyl phenol of fungal origin, scutigeral, stimulates rat dorsal root ganglion neurons via interaction at vanilloid receptors
-
Szallasi A, Biro T, Szabo T, Modarres S, Petersen M, Klusch A, Blumberg PM, Krause JE, Sterner O (1999) A non-pungent triprenyl phenol of fungal origin, scutigeral, stimulates rat dorsal root ganglion neurons via interaction at vanilloid receptors. Br J Pharmacol 126: 1351-1358
-
(1999)
Br J Pharmacol
, vol.126
, pp. 1351-1358
-
-
Szallasi, A.1
Biro, T.2
Szabo, T.3
Modarres, S.4
Petersen, M.5
Klusch, A.6
Blumberg, P.M.7
Krause, J.E.8
Sterner, O.9
-
73
-
-
0038373585
-
Activities of prenylphenol derivatives from fruitbodies of Albatrellus spp. on the human and rat vanilloid receptor 1 (VR1) and characterisation of the novel natural product, confluentin
-
Hellwig V, Nopper R, Mauler F, Freitag J, Ji-Kai L, Zhi-Hui D, Stadler M (2003) Activities of prenylphenol derivatives from fruitbodies of Albatrellus spp. on the human and rat vanilloid receptor 1 (VR1) and characterisation of the novel natural product, confluentin. Arch Pharm (Weinheim) 336:119-126
-
(2003)
Arch Pharm (Weinheim
, vol.336
, pp. 119-126
-
-
Hellwig, V.1
Nopper, R.2
Mauler, F.3
Freitag, J.4
Ji-Kai, L.5
Zhi-Hui, D.6
Stadler, M.7
-
74
-
-
0034751335
-
Molecular targets for cannabidiol and its synthetic analogues: Effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide
-
Bisogno T, Hanus L, De Petrocellis L, Tchilibon S, Ponde DE, Brandi I, Moriello AS, Davis JB, Mechoulam R, Di Marzo V (2001) Molecular targets for cannabidiol and its synthetic analogues: Effect on vanilloid VR1 receptors and on the cellular uptake and enzymatic hydrolysis of anandamide. Br J Pharmacol 134:845-852
-
(2001)
Br J Pharmacol
, vol.134
, pp. 845-852
-
-
Bisogno, T.1
Hanus, L.2
De Petrocellis, L.3
Tchilibon, S.4
Ponde, D.E.5
Brandi, I.6
Moriello, A.S.7
Davis, J.B.8
Mechoulam, R.9
Di Marzo, V.10
-
75
-
-
4744372178
-
Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation
-
Costa B, Giagnoni G, Franke C, Trovato AE, Colleoni M (2004) Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation. Br J Pharmacol 143:247-250
-
(2004)
Br J Pharmacol
, vol.143
, pp. 247-250
-
-
Costa, B.1
Giagnoni, G.2
Franke, C.3
Trovato, A.E.4
Colleoni, M.5
-
76
-
-
0035981233
-
Effects of ginsenosides on vanilloid receptor (VR1) channels expressed in Xenopus oocytes
-
Jung SY, Choi S, Ko YS, Park CS, Oh S, Koh SR, Oh JW, Rhee MH, Nah SY (2001) Effects of ginsenosides on vanilloid receptor (VR1) channels expressed in Xenopus oocytes. Mol Cells 12:342-346
-
(2001)
Mol Cells
, vol.12
, pp. 342-346
-
-
Jung, S.Y.1
Choi, S.2
Ko, Y.S.3
Park, C.S.4
Oh, S.5
Koh, S.R.6
Oh, J.W.7
Rhee, M.H.8
Nah, S.Y.9
-
77
-
-
0343729529
-
Ginsenosides inhibit capsaicin-activated channel in rat sensory neurons
-
Hahn J, Nah SY, Nah JJ, Uhm DY, Chung S (2000) Ginsenosides inhibit capsaicin-activated channel in rat sensory neurons. Neurosci Lett 287:45-48
-
(2000)
Neurosci Lett
, vol.287
, pp. 45-48
-
-
Hahn, J.1
Nah, S.Y.2
Nah, J.J.3
Uhm, D.Y.4
Chung, S.5
-
78
-
-
38349023182
-
Painful toxins acting at TRPV1
-
Cromer BA, McIntyre P (2008) Painful toxins acting at TRPV1. Toxicon 51:163-173
-
(2008)
Toxicon
, vol.51
, pp. 163-173
-
-
Cromer, B.A.1
McIntyre, P.2
-
79
-
-
33750873334
-
Spider toxins activate the capsaicin receptor to produce inflammatory pain
-
Siemens J, Zhou S, Piskorowski R, Nikai T, Lumpkin E, Basbaum AI, King D, Julius D (2006) Spider toxins activate the capsaicin receptor to produce inflammatory pain. Nature 444:208-212
-
(2006)
Nature
, vol.444
, pp. 208-212
-
-
Siemens, J.1
Zhou, S.2
Piskorowski, R.3
Nikai, T.4
Lumpkin, E.5
Basbaum, A.I.6
King, D.7
Julius, D.8
-
80
-
-
28244475780
-
An inhibitor of TRPV1 channels isolated from funnel Web spider venom
-
Kitaguchi T, Swartz KJ (2005) An inhibitor of TRPV1 channels isolated from funnel Web spider venom. Biochemistry 44:15544-15549
-
(2005)
Biochemistry
, vol.44
, pp. 15544-15549
-
-
Kitaguchi, T.1
Swartz, K.J.2
-
81
-
-
53049093899
-
Analgesic compound from sea anemone Heteractis crispa is the first polypeptide inhibitor of vanilloid receptor 1 (TRPV1)
-
Andreev YA, Kozlov SA, Koshelev SG, Ivanova EA, Monastyrnaya MM, Kozlovskaya EP, Grishin EV (2008) Analgesic compound from sea anemone Heteractis crispa is the first polypeptide inhibitor of vanilloid receptor 1 (TRPV1). J Biol Chem 283:23914-23921
-
(2008)
J Biol Chem
, vol.283
, pp. 23914-23921
-
-
Andreev, Y.A.1
Kozlov, S.A.2
Koshelev, S.G.3
Ivanova, E.A.4
Monastyrnaya, M.M.5
Kozlovskaya, E.P.6
Grishin, E.V.7
-
83
-
-
33749376486
-
Jellyfish and other cnidarian envenomations cause pain by affecting TRPV1 channels
-
Cuypers E, Yanagihara A, Karlsson E, Tytgat J (2006) Jellyfish and other cnidarian envenomations cause pain by affecting TRPV1 channels. FEBS Lett 580:5728-5732
-
(2006)
FEBS Lett
, vol.580
, pp. 5728-5732
-
-
Cuypers, E.1
Yanagihara, A.2
Karlsson, E.3
Tytgat, J.4
-
84
-
-
0036303675
-
Vanilloid (capsaicin) receptors in health and disease
-
Szallasi A (2002) Vanilloid (capsaicin) receptors in health and disease. Am J Clin Pathol 118:110-121
-
(2002)
Am J Clin Pathol
, vol.118
, pp. 110-121
-
-
Szallasi, A.1
-
85
-
-
0344670180
-
Dual effect of cannabinoid CB1 receptor stimulation on a vanilloid VR1 receptor-mediated response
-
Hermann H, De Petrocellis L, Bisogno T, Schiano Moriello A, Lutz B, Di Marzo V (2003) Dual effect of cannabinoid CB1 receptor stimulation on a vanilloid VR1 receptor-mediated response. Cell Mol Life Sci 60:607-616
-
(2003)
Cell Mol Life Sci
, vol.60
, pp. 607-616
-
-
Hermann, H.1
De Petrocellis, L.2
Bisogno, T.3
Schiano Moriello, A.4
Lutz, B.5
Di Marzo, V.6
-
87
-
-
0037062411
-
An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors
-
Huang SM, Bisogno T, Trevisani M, Al-Hayani A, De Petrocellis L, Fezza F, Tognetto M, Petros TJ, Krey JF, Chu CJ, Miller JD, Davies SN, Geppetti P, Walker JM, Di Marzo V (2002) An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors. Proc Natl Acad Sci USA 99:8400-8405
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 8400-8405
-
-
Huang, S.M.1
Bisogno, T.2
Trevisani, M.3
Al-Hayani, A.4
De Petrocellis, L.5
Fezza, F.6
Tognetto, M.7
Petros, T.J.8
Krey, J.F.9
Chu, C.J.10
Miller, J.D.11
Davies, S.N.12
Geppetti, P.13
Walker, J.M.14
Di Marzo, V.15
-
88
-
-
0034042852
-
Characterization using FLIPR of rat vanilloid receptor (rVR1) pharmacology
-
Jerman JC, Brough SJ, Prinjha R, Harries MH, Davis JB, Smart D (2000) Characterization using FLIPR of rat vanilloid receptor (rVR1) pharmacology. Br J Pharmacol 130:916-922
-
(2000)
Br J Pharmacol
, vol.130
, pp. 916-922
-
-
Jerman, J.C.1
Brough, S.J.2
Prinjha, R.3
Harries, M.H.4
Davis, J.B.5
Smart, D.6
-
89
-
-
2442608827
-
Activation and sensitisation of the vanilloid receptor: Role in gastrointestinal inflammation and function
-
Geppetti P, Trevisani M (2004) Activation and sensitisation of the vanilloid receptor: Role in gastrointestinal inflammation and function. Br J Pharmacol 141:1313-1320
-
(2004)
Br J Pharmacol
, vol.141
, pp. 1313-1320
-
-
Geppetti, P.1
Trevisani, M.2
-
90
-
-
33644682883
-
Endogenous unsaturated C18 N-acylethanolamines are vanilloid receptor (TRPV1) agonists
-
Movahed P, Jonsson BA, Birnir B, Wingstrand JA, Jorgensen TD, Ermund A, Sterner O, Zygmunt PM, Hogestatt ED (2005) Endogenous unsaturated C18 N-acylethanolamines are vanilloid receptor (TRPV1) agonists. J Biol Chem 280:38496-38504
-
(2005)
J Biol Chem
, vol.280
, pp. 38496-38504
-
-
Movahed, P.1
Jonsson, B.A.2
Birnir, B.3
Wingstrand, J.A.4
Jorgensen, T.D.5
Ermund, A.6
Sterner, O.7
Zygmunt, P.M.8
Hogestatt, E.D.9
-
91
-
-
0033614984
-
Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide
-
Zygmunt PM, Petersson J, Andersson DA, Chuang H, Sorgard M, Di Marzo V, Julius D, Hogestatt ED (1999) Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide. Nature 400:452-457
-
(1999)
Nature
, vol.400
, pp. 452-457
-
-
Zygmunt, P.M.1
Petersson, J.2
Andersson, D.A.3
Chuang, H.4
Sorgard, M.5
Di Marzo, V.6
Julius, D.7
Hogestatt, E.D.8
-
92
-
-
57649217870
-
Microsomal omega-hydroxylated metabolites of N-arachidonoyl dopamine are active at recombinant human TRPV1 receptors
-
Rimmerman N, Bradshaw HB, Basnet A, Tan B, Widlanski TS, Walker JM (2009) Microsomal omega-hydroxylated metabolites of N-arachidonoyl dopamine are active at recombinant human TRPV1 receptors. Prostaglandins Other Lipid Mediat 88:10-17
-
(2009)
Prostaglandins Other Lipid Mediat
, vol.88
, pp. 10-17
-
-
Rimmerman, N.1
Bradshaw, H.B.2
Basnet, A.3
Tan, B.4
Widlanski, T.S.5
Walker, J.M.6
-
93
-
-
4744350135
-
Actions of two naturally occurring saturated N-acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels
-
De Petrocellis L, Chu CJ, Moriello AS, Kellner JC, Walker JM, Di Marzo V (2004) Actions of two naturally occurring saturated N-acyldopamines on transient receptor potential vanilloid 1 (TRPV1) channels. Br J Pharmacol 143:251-256
-
(2004)
Br J Pharmacol
, vol.143
, pp. 251-256
-
-
De Petrocellis, L.1
Chu, C.J.2
Moriello, A.S.3
Kellner, J.C.4
Walker, J.M.5
Di Marzo, V.6
-
94
-
-
0038190980
-
N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia
-
Chu CJ, Huang SM, De Petrocellis L, Bisogno T, Ewing SA, Miller JD, Zipkin RE, Daddario N, Appendino G, Di Marzo V, Walker JM (2003) N-oleoyldopamine, a novel endogenous capsaicin-like lipid that produces hyperalgesia. J Biol Chem 278:13633-13639
-
(2003)
J Biol Chem
, vol.278
, pp. 13633-13639
-
-
Chu, C.J.1
Huang, S.M.2
De Petrocellis, L.3
Bisogno, T.4
Ewing, S.A.5
Miller, J.D.6
Zipkin, R.E.7
Daddario, N.8
Appendino, G.9
Di Marzo, V.10
Walker, J.M.11
-
95
-
-
0042734414
-
Activation of TRPV1 by the satiety factor oleoylethanolamide
-
Ahern GP (2003) Activation of TRPV1 by the satiety factor oleoylethanolamide. J Biol Chem 278:30429-30434
-
(2003)
J Biol Chem
, vol.278
, pp. 30429-30434
-
-
Ahern, G.P.1
-
96
-
-
77951787575
-
Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents
-
Patwardhan AM, Akopian AN, Ruparel NB, Diogenes A, Weintraub ST, Uhlson C, Murphy RC, Hargreaves KM (2010) Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents. J Clin Invest 120(5):1617-1626.
-
(2010)
J Clin Invest
, vol.120
, Issue.5
, pp. 1617-1626
-
-
Patwardhan, A.M.1
Akopian, A.N.2
Ruparel, N.B.3
Diogenes, A.4
Weintraub, S.T.5
Uhlson, C.6
Murphy, R.C.7
Hargreaves, K.M.8
-
97
-
-
73249131229
-
Activation of TRPV1 in the spinal cord by oxidized linoleic acid metabolites contributes to inflammatory hyperalgesia
-
Patwardhan AM, Scotland PE, Akopian AN, Hargreaves KM (2009) Activation of TRPV1 in the spinal cord by oxidized linoleic acid metabolites contributes to inflammatory hyperalgesia. Proc Natl Acad Sci USA 106:18820-18824
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 18820-18824
-
-
Patwardhan, A.M.1
Scotland, P.E.2
Akopian, A.N.3
Hargreaves, K.M.4
-
98
-
-
77952351011
-
Nitro-oleic acid inhibits firing and activates TRPV1- and TRPA1-mediated inward currents in DRG neurons from adult male rats
-
Sculptoreanu A, Kullmann FA, Artim DE, Bazley FA, Schopfer F, Woodcock S, Freeman BA, de Groat W (2010) Nitro-oleic acid inhibits firing and activates TRPV1- and TRPA1-mediated inward currents in DRG neurons from adult male rats. J Pharmacol Exp Ther 333(3):883-895.
-
(2010)
J Pharmacol Exp Ther
, vol.333
, Issue.3
, pp. 883-895
-
-
Sculptoreanu, A.1
Kullmann, F.A.2
Artim, D.E.3
Bazley, F.A.4
Schopfer, F.5
Woodcock, S.6
Freeman, B.A.7
De Groat, W.8
-
99
-
-
33746657575
-
A FAAHregulated class of N-acyl taurines that activates TRP ion channels
-
Saghatelian A, McKinney MK, Bandell M, Patapoutian A, Cravatt BF (2006) A FAAHregulated class of N-acyl taurines that activates TRP ion channels. Biochemistry 45: 9007-9015
-
(2006)
Biochemistry
, vol.45
, pp. 9007-9015
-
-
Saghatelian, A.1
McKinney, M.K.2
Bandell, M.3
Patapoutian, A.4
Cravatt, B.F.5
-
100
-
-
0034721957
-
Antinociceptive activity of ricinoleic acid, a capsaicin-like compound devoid of pungent properties
-
Vieira C, Evangelista S, Cirillo R, Terracciano R, Lippi A, Maggi CA, Manzini S (2000) Antinociceptive activity of ricinoleic acid, a capsaicin-like compound devoid of pungent properties. Eur J Pharmacol 407:109-116
-
(2000)
Eur J Pharmacol
, vol.407
, pp. 109-116
-
-
Vieira, C.1
Evangelista, S.2
Cirillo, R.3
Terracciano, R.4
Lippi, A.5
Maggi, C.A.6
Manzini, S.7
-
101
-
-
0034531052
-
Effect of ricinoleic acid in acute and subchronic experimental models of inflammation
-
Vieira C, Evangelista S, Cirillo R, Lippi A, Maggi CA,Manzini S (2000) Effect of ricinoleic acid in acute and subchronic experimental models of inflammation. Mediators Inflamm 9:223-228
-
(2000)
Mediators Inflamm
, vol.9
, pp. 223-228
-
-
Vieira, C.1
Evangelista, S.2
Cirillo, R.3
Lippi, A.4
Maggi, C.A.5
Manzini, S.6
-
102
-
-
0034901343
-
Pro- and anti-inflammatory actions of ricinoleic acid: Similarities and differences with capsaicin
-
Vieira C, Fetzer S, Sauer SK, Evangelista S, Averbeck B, Kress M, Reeh PW, Cirillo R, Lippi A, Maggi CA, Manzini S (2001) Pro- and anti-inflammatory actions of ricinoleic acid: Similarities and differences with capsaicin. Naunyn Schmiedebergs Arch Pharmacol 364:87-95
-
(2001)
Naunyn Schmiedebergs Arch Pharmacol
, vol.364
, pp. 87-95
-
-
Vieira, C.1
Fetzer, S.2
Sauer, S.K.3
Evangelista, S.4
Averbeck, B.5
Kress, M.6
Reeh, P.W.7
Cirillo, R.8
Lippi, A.9
Maggi, C.A.10
Manzini, S.11
-
103
-
-
0036294731
-
Thapsigargin binds to and inhibits the cloned vanilloid receptor-1
-
Toth A, Kedei N, Szabo T,Wang Y, Blumberg PM (2002) Thapsigargin binds to and inhibits the cloned vanilloid receptor-1. Biochem Biophys Res Commun 293:777-782
-
(2002)
Biochem Biophys Res Commun
, vol.293
, pp. 777-782
-
-
Toth, A.1
Kedei, N.2
Szabo, T.3
Wang, Y.4
Blumberg, P.M.5
-
104
-
-
1542615229
-
Nicotine inhibits voltage-dependent sodium channels and sensitizes vanilloid receptors
-
Liu L, Zhu W, Zhang ZS, Yang T, Grant A, Oxford G, Simon SA (2004) Nicotine inhibits voltage-dependent sodium channels and sensitizes vanilloid receptors. J Neurophysiol 91:1482-1491
-
(2004)
J Neurophysiol
, vol.91
, pp. 1482-1491
-
-
Liu, L.1
Zhu, W.2
Zhang, Z.S.3
Yang, T.4
Grant, A.5
Oxford, G.6
Simon, S.A.7
-
105
-
-
1642538393
-
Yohimbine inhibits firing activities of rat dorsal root ganglion neurons by blocking Na+ channels and vanilloid VR1 receptors
-
Dessaint J, Yu W, Krause JE, Yue L (2004) Yohimbine inhibits firing activities of rat dorsal root ganglion neurons by blocking Na+ channels and vanilloid VR1 receptors. Eur J Pharmacol 485:11-20
-
(2004)
Eur J Pharmacol
, vol.485
, pp. 11-20
-
-
Dessaint, J.1
Yu, W.2
Krause, J.E.3
Yue, L.4
-
106
-
-
33646845297
-
Polyamines are potent ligands for the capsaicin receptor TRPV1
-
Ahern GP, Wang X, Miyares RL (2006) Polyamines are potent ligands for the capsaicin receptor TRPV1. J Biol Chem 281:8991-8995
-
(2006)
J Biol Chem
, vol.281
, pp. 8991-8995
-
-
Ahern, G.P.1
Wang, X.2
Miyares, R.L.3
-
107
-
-
4644282932
-
Evodiamine functions as an agonist for the vanilloid receptor TRPV1
-
Pearce LV, Petukhov PA, Szabo T, Kedei N, Bizik F, Kozikowski AP, Blumberg PM (2004) Evodiamine functions as an agonist for the vanilloid receptor TRPV1. Org Biomol Chem 2:2281-2286
-
(2004)
Org Biomol Chem
, vol.2
, pp. 2281-2286
-
-
Pearce, L.V.1
Petukhov, P.A.2
Szabo, T.3
Kedei, N.4
Bizik, F.5
Kozikowski, A.P.6
Blumberg, P.M.7
-
108
-
-
71749101583
-
Evodiamine inhibits adipogenesis via the EGFRPKCalpha- ERK signaling pathway
-
Wang T, Wang Y, Yamashita H (2009) Evodiamine inhibits adipogenesis via the EGFRPKCalpha- ERK signaling pathway. FEBS Lett 583:3655-3659
-
(2009)
FEBS Lett
, vol.583
, pp. 3655-3659
-
-
Wang, T.1
Wang, Y.2
Yamashita, H.3
-
109
-
-
59449092140
-
Involvement of transient receptor potential vanilloid subtype 1 in analgesic action of methylsalicylate
-
Ohta T, Imagawa T, Ito S (2009) Involvement of Transient Receptor Potential Vanilloid Subtype 1 in Analgesic Action of Methylsalicylate. Mol Pharmacol 75:307-317
-
(2009)
Mol Pharmacol
, vol.75
, pp. 307-317
-
-
Ohta, T.1
Imagawa, T.2
Ito, S.3
-
110
-
-
4243578738
-
Inhibition of capsaicin-induced ionic current - A new mechanism of action for aspirin-like drugs?
-
Abstract
-
KressM, Vyklicky L, Reeh PW (1996) Inhibition of capsaicin-induced ionic current - a new mechanism of action for aspirin-like drugs? Pflugers Arch - Eur J Physiol Suppl 431:R61 Abstract
-
(1996)
Pflugers Arch - Eur J Physiol Suppl
, vol.431
-
-
KressM Vyklicky, L.1
Reeh, P.W.2
-
111
-
-
0036498993
-
Acetylsalicylic acid reduces heat responses in rat nociceptive primary sensory neurons - evidence for a new mechanism of action
-
Greffrath W, Kirschstein T, Nawrath H, Treede R (2002) Acetylsalicylic acid reduces heat responses in rat nociceptive primary sensory neurons - evidence for a new mechanism of action. Neurosci Lett 320:61-64
-
(2002)
Neurosci Lett
, vol.320
, pp. 61-64
-
-
Greffrath, W.1
Kirschstein, T.2
Nawrath, H.3
Treede, R.4
-
112
-
-
0033119629
-
A capsaicin-receptor homologue with a high threshold for noxious heat
-
Caterina MJ, Rosen TA, Tominaga M, Brake AJ, Julius D (1999) A capsaicin-receptor homologue with a high threshold for noxious heat. Nature 398:436-441
-
(1999)
Nature
, vol.398
, pp. 436-441
-
-
Caterina, M.J.1
Rosen, T.A.2
Tominaga, M.3
Brake, A.J.4
Julius, D.5
-
113
-
-
34447134440
-
Activation properties of heterologously expressed mammalian TRPV2: Evidence for species dependence
-
Neeper MP, Liu Y, Hutchinson TL, Wang Y, Flores CM, Qin N (2007) Activation properties of heterologously expressed mammalian TRPV2: Evidence for species dependence. J Biol Chem 282:15894-15902
-
(2007)
J Biol Chem
, vol.282
, pp. 15894-15902
-
-
Neeper, M.P.1
Liu, Y.2
Hutchinson, T.L.3
Wang, Y.4
Flores, C.M.5
Qin, N.6
-
114
-
-
0242266967
-
TRPV2 is a component of osmotically sensitive cation channels in murine aortic myocytes
-
Muraki K, Iwata Y, Katanosaka Y, Ito T, Ohya S, Shigekawa M, Imaizumi Y (2003) TRPV2 is a component of osmotically sensitive cation channels in murine aortic myocytes. Circ Res 93:829-838
-
(2003)
Circ Res
, vol.93
, pp. 829-838
-
-
Muraki, K.1
Iwata, Y.2
Katanosaka, Y.3
Ito, T.4
Ohya, S.5
Shigekawa, M.6
Imaizumi, Y.7
-
115
-
-
38749149923
-
Cannabinoids desensitize capsaicin and mustard oil responses in sensory neurons via TRPA1 activation
-
Akopian AN, Ruparel NB, Patwardhan A, Hargreaves KM (2008) Cannabinoids desensitize capsaicin and mustard oil responses in sensory neurons via TRPA1 activation. J Neurosci 28:1064-1075
-
(2008)
J Neurosci
, vol.28
, pp. 1064-1075
-
-
Akopian, A.N.1
Ruparel, N.B.2
Patwardhan, A.3
Hargreaves, K.M.4
-
116
-
-
1642430679
-
Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1
-
Jordt SE, Bautista DM, Chuang HH, McKemy DD, Zygmunt PM, Hogestatt ED, Meng ID, Julius D (2004) Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature 427:260-265
-
(2004)
Nature
, vol.427
, pp. 260-265
-
-
Jordt, S.E.1
Bautista, D.M.2
Chuang, H.H.3
McKemy, D.D.4
Zygmunt, P.M.5
Hogestatt, E.D.6
Meng, I.D.7
Julius, D.8
-
117
-
-
46749129338
-
TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons
-
Qin N, Neeper MP, Liu Y, Hutchinson TL, LubinML, Flores CM (2008) TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. J Neurosci 28:6231-6238
-
(2008)
J Neurosci
, vol.28
, pp. 6231-6238
-
-
Qin, N.1
Neeper, M.P.2
Liu, Y.3
Hutchinson, T.L.4
Lubin, M.L.5
Flores, C.M.6
-
118
-
-
34548637630
-
Transient receptor potential V2 expressed in sensory neurons is activated by probenecid
-
Bang S, Kim KY, Yoo S, Lee SH, Hwang SW (2007) Transient receptor potential V2 expressed in sensory neurons is activated by probenecid. Neurosci Lett 425:120-125
-
(2007)
Neurosci Lett
, vol.425
, pp. 120-125
-
-
Bang, S.1
Kim, K.Y.2
Yoo, S.3
Lee, S.H.4
Hwang, S.W.5
-
119
-
-
60849118922
-
Lehen'kyi V, Pourtier A, Vanden Abeele F, Bidaux G, Juvin V, Rassendren F, Humez S, Prevarsakaya N: Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation
-
Monet M, Gkika D (2009) Lehen'kyi V, Pourtier A, Vanden Abeele F, Bidaux G, Juvin V, Rassendren F, Humez S, Prevarsakaya N: Lysophospholipids stimulate prostate cancer cell migration via TRPV2 channel activation. Biochim Biophys Acta 1793:528-539
-
(2009)
Biochim Biophys Acta
, vol.1793
, pp. 528-539
-
-
Monet, M.1
Gkika, D.2
-
120
-
-
0037077041
-
A heat-sensitive TRP channel expressed in keratinocytes
-
Peier AM, Reeve AJ, Andersson DA, Moqrich A, Earley TJ, Hergarden AC, Story GM, Colley S, Hogenesch JB, McIntyre P, Bevan S, Patapoutian A (2002) A heat-sensitive TRP channel expressed in keratinocytes. Science 296:2046-2049
-
(2002)
Science
, vol.296
, pp. 2046-2049
-
-
Peier, A.M.1
Reeve, A.J.2
Andersson, D.A.3
Moqrich, A.4
Earley, T.J.5
Hergarden, A.C.6
Story, G.M.7
Colley, S.8
Hogenesch, J.B.9
McIntyre, P.10
Bevan, S.11
Patapoutian, A.12
-
121
-
-
18444408683
-
TRPV3 is a temperature-sensitive vanilloid receptor-like protein
-
Smith GD, Gunthorpe MJ, Kelsell RE, Hayes PD, Reilly P, Facer P, Wright JE, Jerman JC, Walhin JP, Ooi L, Egerton J, Charles KJ, Smart D, Randall AD, Anand P, Davis JB (2002) TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature 418: 186-190
-
(2002)
Nature
, vol.418
, pp. 186-190
-
-
Smith, G.D.1
Gunthorpe, M.J.2
Kelsell, R.E.3
Hayes, P.D.4
Reilly, P.5
Facer, P.6
Wright, J.E.7
Jerman, J.C.8
Walhin, J.P.9
Ooi, L.10
Egerton, J.11
Charles, K.J.12
Smart, D.13
Randall, A.D.14
Anand, P.15
Davis, J.B.16
-
122
-
-
0037062915
-
TRPV3 is a calcium-permeable temperature-sensitive cation channel
-
Xu H, Ramsey IS, Kotecha SA, Moran MM, Chong JA, Lawson D, Ge P, Lilly J, Silos-Santiago I, Xie Y, DiStefano PS, Curtis R, Clapham DE (2002) TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature 418:181-186
-
(2002)
Nature
, vol.418
, pp. 181-186
-
-
Xu, H.1
Ramsey, I.S.2
Kotecha, S.A.3
Moran, M.M.4
Chong, J.A.5
Lawson, D.6
Ge, P.7
Lilly, J.8
Silos-Santiago, I.9
Xie, Y.10
DiStefano, P.S.11
Curtis, R.12
Clapham, D.E.13
-
123
-
-
14644392188
-
Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin
-
Moqrich A, Hwang SW, Earley TJ, Petrus MJ, Murray AN, Spencer KS, Andahazy M, Story GM, Patapoutian A (2005) Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin. Science 307:1468-1472
-
(2005)
Science
, vol.307
, pp. 1468-1472
-
-
Moqrich, A.1
Hwang, S.W.2
Earley, T.J.3
Petrus, M.J.4
Murray, A.N.5
Spencer, K.S.6
Andahazy, M.7
Story, G.M.8
Patapoutian, A.9
-
124
-
-
26244447712
-
The TRPV1/2/3 activator 2-aminoethoxydiphenyl borate sensitizes native nociceptive neurons to heat in wildtype but not TRPV1 deficient mice
-
Zimmermann K, Leffler A, Fischer MM, Messlinger K, Nau C, Reeh PW (2005) The TRPV1/2/3 activator 2-aminoethoxydiphenyl borate sensitizes native nociceptive neurons to heat in wildtype but not TRPV1 deficient mice. Neuroscience 135:1277-1284
-
(2005)
Neuroscience
, vol.135
, pp. 1277-1284
-
-
Zimmermann, K.1
Leffler, A.2
Fischer, M.M.3
Messlinger, K.4
Nau, C.5
Reeh, P.W.6
-
126
-
-
33751112985
-
Association of a mutation in TRPV3 with defective hair growth in rodents
-
Asakawa M, Yoshioka T, Matsutani T, Hikita I, Suzuki M, Oshima I, Tsukahara K, Arimura A, Horikawa T, Hirasawa T, Sakata T (2006) Association of a mutation in TRPV3 with defective hair growth in rodents. J Invest Dermatol 126:2664-2672
-
(2006)
J Invest Dermatol
, vol.126
, pp. 2664-2672
-
-
Asakawa, M.1
Yoshioka, T.2
Matsutani, T.3
Hikita, I.4
Suzuki, M.5
Oshima, I.6
Tsukahara, K.7
Arimura, A.8
Horikawa, T.9
Hirasawa, T.10
Sakata, T.11
-
127
-
-
34848904486
-
Influence of TRPV3 mutation on hair growth cycle in mice
-
Imura K, Yoshioka T, Hikita I, Tsukahara K, Hirasawa T, Higashino K, Gahara Y, Arimura A, Sakata T (2007) Influence of TRPV3 mutation on hair growth cycle in mice. Biochem Biophys Res Commun 363:479-483
-
(2007)
Biochem Biophys Res Commun
, vol.363
, pp. 479-483
-
-
Imura, K.1
Yoshioka, T.2
Hikita, I.3
Tsukahara, K.4
Hirasawa, T.5
Higashino, K.6
Gahara, Y.7
Arimura, A.8
Sakata, T.9
-
128
-
-
34250160572
-
Monoterpenoid agonists of TRPV3
-
Vogt-Eisele AK, Weber K, Sherkheli MA, Vielhaber G, Panten J, Gisselmann G, Hatt H (2007) Monoterpenoid agonists of TRPV3. Br J Pharmacol 151:530-540
-
(2007)
Br J Pharmacol
, vol.151
, pp. 530-540
-
-
Vogt-Eisele, A.K.1
Weber, K.2
Sherkheli, M.A.3
Vielhaber, G.4
Panten, J.5
Gisselmann, G.6
Hatt, H.7
-
129
-
-
18144421118
-
Biphasic currents evoked by chemical or thermal activation of the heat-gated ion channel, TRPV3
-
Chung MK, Guler AD, Caterina MJ (2005) Biphasic currents evoked by chemical or thermal activation of the heat-gated ion channel, TRPV3. J Biol Chem 280:15928-15941
-
(2005)
J Biol Chem
, vol.280
, pp. 15928-15941
-
-
Chung, M.K.1
Guler, A.D.2
Caterina, M.J.3
-
130
-
-
25644433563
-
Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism
-
Xu H, Blair NT, Clapham DE (2005) Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism. J Neurosci 25:8924-8937
-
(2005)
J Neurosci
, vol.25
, pp. 8924-8937
-
-
Xu, H.1
Blair, N.T.2
Clapham, D.E.3
-
131
-
-
61449223525
-
Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels
-
Parnas M, Peters M, Dadon D, Lev S, Vertkin I, Slutsky I, Minke B (2009) Carvacrol is a novel inhibitor of Drosophila TRPL and mammalian TRPM7 channels. Cell Calcium 45:300-309
-
(2009)
Cell Calcium
, vol.45
, pp. 300-309
-
-
Parnas, M.1
Peters, M.2
Dadon, D.3
Lev, S.4
Vertkin, I.5
Slutsky, I.6
Minke, B.7
-
132
-
-
33746716158
-
More than cool: Promiscuous relationships of menthol and other sensory compounds
-
Macpherson LJ, Hwang SW, Miyamoto T, Dubin AE, Patapoutian A, Story GM (2006) More than cool: Promiscuous relationships of menthol and other sensory compounds. Mol Cell Neurosci 32:335-343
-
(2006)
Mol Cell Neurosci
, vol.32
, pp. 335-343
-
-
Macpherson, L.J.1
Hwang, S.W.2
Miyamoto, T.3
Dubin, A.E.4
Patapoutian, A.5
Story, G.M.6
-
133
-
-
0037034931
-
Identification of a cold receptor reveals a general role for TRP channels in thermosensation
-
McKemy DD, Neuhausser WM, Julius D (2002) Identification of a cold receptor reveals a general role for TRP channels in thermosensation. Nature 416:52-58
-
(2002)
Nature
, vol.416
, pp. 52-58
-
-
McKemy, D.D.1
Neuhausser, W.M.2
Julius, D.3
-
134
-
-
18344386202
-
A TRP channel that senses cold stimuli and menthol
-
Peier AM, Moqrich A, Hergarden AC, Reeve AJ, Andersson DA, Story GM, Earley TJ, Dragoni I, McIntyre P, Bevan S, Patapoutian A (2002) A TRP channel that senses cold stimuli and menthol. Cell 108:705-715
-
(2002)
Cell
, vol.108
, pp. 705-715
-
-
Peier, A.M.1
Moqrich, A.2
Hergarden, A.C.3
Reeve, A.J.4
Andersson, D.A.5
Story, G.M.6
Earley, T.J.7
Dragoni, I.8
McIntyre, P.9
Bevan, S.10
Patapoutian, A.11
-
135
-
-
1842453817
-
Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay
-
Behrendt HJ, Germann T, Gillen C, Hatt H, Jostock R (2004) Characterization of the mouse cold-menthol receptor TRPM8 and vanilloid receptor type-1 VR1 using a fluorometric imaging plate reader (FLIPR) assay. Br J Pharmacol 141:737-745
-
(2004)
Br J Pharmacol
, vol.141
, pp. 737-745
-
-
Behrendt, H.J.1
Germann, T.2
Gillen, C.3
Hatt, H.4
Jostock, R.5
-
136
-
-
47749137425
-
Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons
-
Stotz SC, Vriens J, Martyn D, Clardy J, Clapham DE (2008) Citral sensing by Transient [corrected] receptor potential channels in dorsal root ganglion neurons. PLoS One 3: E2082
-
(2008)
PLoS One
, vol.3
-
-
Stotz, S.C.1
Vriens, J.2
Martyn, D.3
Clardy, J.4
Clapham, D.E.5
-
137
-
-
48749095422
-
Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain
-
Moussaieff A, Rimmerman N, Bregman T, Straiker A, Felder CC, Shoham S, Kashman Y, Huang SM, Lee H, Shohami E, Mackie K, Caterina MJ, Walker JM, Fride E, Mechoulam R (2008) Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain. Faseb J 22:3024-3034
-
(2008)
Faseb J
, vol.22
, pp. 3024-3034
-
-
Moussaieff, A.1
Rimmerman, N.2
Bregman, T.3
Straiker, A.4
Felder, C.C.5
Shoham, S.6
Kashman, Y.7
Huang, S.M.8
Lee, H.9
Shohami, E.10
Mackie, K.11
Caterina, M.J.12
Walker, J.M.13
Fride, E.14
Mechoulam, R.15
-
138
-
-
77953527601
-
Farnesyl pyrophosphate is a novel painproducing molecule via specific activation of TRPV3
-
Bang S, Yoo S, Yang TJ, Cho H, Hwang SW (2010) Farnesyl pyrophosphate is a novel painproducing molecule via specific activation of TRPV3. J Biol Chem 285(25):19362-19371.
-
(2010)
J Biol Chem
, vol.285
, Issue.25
, pp. 19362-19371
-
-
Bang, S.1
Yoo, S.2
Yang, T.J.3
Cho, H.4
Hwang, S.W.5
-
139
-
-
0034721648
-
Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor
-
Liedtke W, Choe Y, Marti-Renom MA, Bell AM, Denis CS, Sali A, Hudspeth AJ, Friedman JM, Heller S (2000) Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell 103:525-535
-
(2000)
Cell
, vol.103
, pp. 525-535
-
-
Liedtke, W.1
Choe, Y.2
Marti-Renom, M.A.3
Bell, A.M.4
Denis, C.S.5
Sali, A.6
Hudspeth, A.J.7
Friedman, J.M.8
Heller, S.9
-
140
-
-
0034306198
-
OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity
-
Strotmann R, Harteneck C, Nunnenmacher K, Schultz G, Plant TD (2000) OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat Cell Biol 2:695-702
-
(2000)
Nat Cell Biol
, vol.2
, pp. 695-702
-
-
Strotmann, R.1
Harteneck, C.2
Nunnenmacher, K.3
Schultz, G.4
Plant, T.D.5
-
141
-
-
0034711336
-
Trp12, a novel Trp related protein from kidney
-
Wissenbach U, Bodding M, Freichel M, Flockerzi V (2000) Trp12, a novel Trp related protein from kidney. FEBS Lett 485:127-134
-
(2000)
FEBS Lett
, vol.485
, pp. 127-134
-
-
Wissenbach, U.1
Bodding, M.2
Freichel, M.3
Flockerzi, V.4
-
142
-
-
0035183983
-
Differential activation of the volume-sensitive cation channel TRP12 (OTRPC4) and volume-regulated anion currents in HEK-293 cells
-
Nilius B, Prenen J, Wissenbach U, Bodding M, Droogmans G (2001) Differential activation of the volume-sensitive cation channel TRP12 (OTRPC4) and volume-regulated anion currents in HEK-293 cells. Pflugers Arch 443:227-233
-
(2001)
Pflugers Arch
, vol.443
, pp. 227-233
-
-
Nilius, B.1
Prenen, J.2
Wissenbach, U.3
Bodding, M.4
Droogmans, G.5
-
143
-
-
0037033077
-
Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells
-
Watanabe H, Vriens J, Suh SH, Benham CD, Droogmans G, Nilius B (2002) Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells. J Biol Chem 277:47044-47051
-
(2002)
J Biol Chem
, vol.277
, pp. 47044-47051
-
-
Watanabe, H.1
Vriens, J.2
Suh, S.H.3
Benham, C.D.4
Droogmans, G.5
Nilius, B.6
-
144
-
-
0036703646
-
Heat-evoked activation of the ion channel, TRPV4
-
Guler AD, Lee H, Iida T, Shimizu I, Tominaga M, CaterinaM(2002) Heat-evoked activation of the ion channel, TRPV4. J Neurosci 22:6408-6414
-
(2002)
J Neurosci
, vol.22
, pp. 6408-6414
-
-
Guler, A.D.1
Lee, H.2
Iida, T.3
Shimizu, I.4
Tominaga, M.5
Caterina, M.6
-
146
-
-
33749562292
-
Bisandrographolide from Andrographis paniculata activates TRPV4 channels
-
Smith PL, Maloney KN, Pothen RG, Clardy J, Clapham DE (2006) Bisandrographolide from Andrographis paniculata activates TRPV4 channels. J Biol Chem 281:29897-29904
-
(2006)
J Biol Chem
, vol.281
, pp. 29897-29904
-
-
Smith, P.L.1
Maloney, K.N.2
Pothen, R.G.3
Clardy, J.4
Clapham, D.E.5
-
147
-
-
34250327530
-
Determinants of 4 alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4
-
Vriens J, Owsianik G, Janssens A, Voets T, Nilius B (2007) Determinants of 4 alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4. J Biol Chem 282:12796-12803
-
(2007)
J Biol Chem
, vol.282
, pp. 12796-12803
-
-
Vriens, J.1
Owsianik, G.2
Janssens, A.3
Voets, T.4
Nilius, B.5
-
148
-
-
2442669228
-
TRPV3 and TRPV4 mediate warmth-evoked currents in primary mouse keratinocytes
-
Chung MK, Lee H, Mizuno A, Suzuki M, Caterina MJ (2004) TRPV3 and TRPV4 mediate warmth-evoked currents in primary mouse keratinocytes. J Biol Chem 279: 21569-21575
-
(2004)
J Biol Chem
, vol.279
, pp. 21569-21575
-
-
Chung, M.K.1
Lee, H.2
Mizuno, A.3
Suzuki, M.4
Caterina, M.J.5
-
149
-
-
77955305225
-
The vallinoid transient receptor potential channel Trpv4: From structure to disease
-
EveraertsW, Nilius B, Owsianik G (2009) The vallinoid transient receptor potential channel Trpv4: From structure to disease. Prog Biophys Mol Biol 103(1):2-17
-
(2009)
Prog Biophys Mol Biol
, vol.103
, Issue.1
, pp. 2-17
-
-
EveraertsW Nilius, B.1
Owsianik, G.2
-
150
-
-
0038604287
-
Impaired pressure sensation in mice lacking TRPV4
-
Suzuki M, Mizuno A, Kodaira K, ImaiM(2003) Impaired pressure sensation in mice lacking TRPV4. J Biol Chem 278:22664-22668
-
(2003)
J Biol Chem
, vol.278
, pp. 22664-22668
-
-
Suzuki, M.1
Mizuno, A.2
Kodaira, K.3
Imai, M.4
-
151
-
-
33645557094
-
A transient receptor potential vanilloid 4-dependent mechanism of hyperalgesia is engaged by concerted action of inflammatory mediators
-
Alessandri-Haber N, Dina OA, Joseph EK, Reichling D, Levine JD (2006) A transient receptor potential vanilloid 4-dependent mechanism of hyperalgesia is engaged by concerted action of inflammatory mediators. J Neurosci 26:3864-3874
-
(2006)
J Neurosci
, vol.26
, pp. 3864-3874
-
-
Alessandri-Haber, N.1
Dina, O.A.2
Joseph, E.K.3
Reichling, D.4
Levine, J.D.5
-
152
-
-
2342666609
-
Transient receptor potential vanilloid 4 is essential in chemotherapy-induced neuropathic pain in the rat
-
Alessandri-Haber N, Dina OA, Yeh JJ, Parada CA, Reichling DB, Levine JD (2004) Transient receptor potential vanilloid 4 is essential in chemotherapy-induced neuropathic pain in the rat. J Neurosci 24:4444-4452
-
(2004)
J Neurosci
, vol.24
, pp. 4444-4452
-
-
Alessandri-Haber, N.1
Dina, O.A.2
Yeh, J.J.3
Parada, C.A.4
Reichling, D.B.5
Levine, J.D.6
-
153
-
-
27644447312
-
TRPV4 mediates pain-related behavior induced by mild hypertonic stimuli in the presence of inflammatory mediator
-
Alessandri-Haber N, Joseph E, Dina OA, Liedtke W, Levine JD (2005) TRPV4 mediates pain-related behavior induced by mild hypertonic stimuli in the presence of inflammatory mediator. Pain 118:70-79
-
(2005)
Pain
, vol.118
, pp. 70-79
-
-
Alessandri-Haber, N.1
Joseph, E.2
Dina, O.A.3
Liedtke, W.4
Levine, J.D.5
-
154
-
-
0041695412
-
Hypotonicity induces TRPV4-mediated nociception in rat
-
Alessandri-Haber N, Yeh JJ, Boyd AE, Parada CA, Chen X, Reichling DB, Levine JD (2003) Hypotonicity induces TRPV4-mediated nociception in rat. Neuron 39:497-511
-
(2003)
Neuron
, vol.39
, pp. 497-511
-
-
Alessandri-Haber, N.1
Yeh, J.J.2
Boyd, A.E.3
Parada, C.A.4
Chen, X.5
Reichling, D.B.6
Levine, J.D.7
-
155
-
-
75749129058
-
Channelopathies converge on TRPV4
-
Nilius B, Owsianik G (2010) Channelopathies converge on TRPV4. Nat Genet 42:98-100
-
(2010)
Nat Genet
, vol.42
, pp. 98-100
-
-
Nilius, B.1
Owsianik, G.2
-
156
-
-
75749129360
-
Alterations in the ankyrin domain of TRPV4 cause congenital distal SMA, scapuloperoneal SMA and HMSN2C
-
Auer-Grumbach M, Olschewski A, Papic L, Kremer H,McEntagartME, Uhrig S, Fischer C, Frohlich E, Balint Z, Tang B, Strohmaier H, Lochmuller H, Schlotter-Weigel B, Senderek J, Krebs A, Dick KJ, Petty R, Longman C, Anderson NE, Padberg GW, Schelhaas HJ, van Ravenswaaij-Arts CM, Pieber TR, Crosby AH, Guelly C (2010) Alterations in the ankyrin domain of TRPV4 cause congenital distal SMA, scapuloperoneal SMA and HMSN2C. Nat Genet 42:160-164
-
(2010)
Nat Genet
, vol.42
, pp. 160-164
-
-
Auer-Grumbach, M.1
Olschewski, A.2
Papic, L.3
Kremer, H.4
McEntagart, M.E.5
Uhrig, S.6
Fischer, C.7
Frohlich, E.8
Balint, Z.9
Tang, B.10
Strohmaier, H.11
Lochmuller, H.12
Schlotter-Weigel, B.13
Senderek, J.14
Krebs, A.15
Dick, K.J.16
Petty, R.17
Longman, C.18
Anderson, N.E.19
Padberg, G.W.20
Schelhaas, H.J.21
Van Ravenswaaij-Arts, C.M.22
Pieber, T.R.23
Crosby, A.H.24
Guelly, C.25
more..
-
157
-
-
75749139617
-
Mutations in TRPV4 cause Charcot- Marie-Tooth disease type 2C
-
Landoure G, Zdebik AA, Martinez TL, Burnett BG, Stanescu HC, Inada H, Shi Y, Taye AA, Kong L, Munns CH, Choo SS, Phelps CB, Paudel R, Houlden H, Ludlow CL, Caterina MJ, Gaudet R, Kleta R, Fischbeck KH, Sumner CJ (2010) Mutations in TRPV4 cause Charcot- Marie-Tooth disease type 2C. Nat Genet 42:170-174
-
(2010)
Nat Genet
, vol.42
, pp. 170-174
-
-
Landoure, G.1
Zdebik, A.A.2
Martinez, T.L.3
Burnett, B.G.4
Stanescu, H.C.5
Inada, H.6
Shi, Y.7
Taye, A.A.8
Kong, L.9
Munns, C.H.10
Choo, S.S.11
Phelps, C.B.12
Paudel, R.13
Houlden, H.14
Ludlow, C.L.15
Caterina, M.J.16
Gaudet, R.17
Kleta, R.18
Fischbeck, K.H.19
Sumner, C.J.20
more..
-
158
-
-
0014353314
-
Cocarcinogenic principles from the seed oil of Croton tiglium and from other Euphorbiaceae
-
Hecker E (1968) Cocarcinogenic principles from the seed oil of Croton tiglium and from other Euphorbiaceae. Cancer Res 28:2338-2349
-
(1968)
Cancer Res
, vol.28
, pp. 2338-2349
-
-
Hecker, E.1
-
159
-
-
34547472118
-
Phorbol esters: Structure, biological activity, and toxicity in animals
-
Goel G, Makkar HP, Francis G, Becker K (2007) Phorbol esters: Structure, biological activity, and toxicity in animals. Int J Toxicol 26:279-288
-
(2007)
Int J Toxicol
, vol.26
, pp. 279-288
-
-
Goel, G.1
Makkar, H.P.2
Francis, G.3
Becker, K.4
-
160
-
-
0019180436
-
Alpha-Tocopherol inhibits 12-O-tetradecanoyl-phorbol-13- acetate-stimulated deacylation of cellular lipids, prostaglandin production, and changes in cell morphology of Madin-Darby canine kidney cells
-
Ohuchi K, Levine L (1980) alpha-Tocopherol inhibits 12-O-tetradecanoyl- phorbol-13- acetate-stimulated deacylation of cellular lipids, prostaglandin production, and changes in cell morphology of Madin-Darby canine kidney cells. Biochim Biophys Acta 619: 11-19
-
(1980)
Biochim Biophys Acta
, vol.619
, pp. 11-19
-
-
Ohuchi, K.1
Levine, L.2
-
161
-
-
0038754049
-
Phorbol esters and neurotransmitter release more than just protein kinase C?
-
Silinsky EM, Searl TJ (2003) Phorbol esters and neurotransmitter release: More than just protein kinase C? Br J Pharmacol 138:1191-1201
-
(2003)
Br J Pharmacol
, vol.138
, pp. 1191-1201
-
-
Silinsky, E.M.1
Searl, T.J.2
-
162
-
-
0021247065
-
Mechanism of action of the phorbol ester tumor promoters: Specific receptors for lipophilic ligands
-
Blumberg PM, Jaken S, Konig B, Sharkey NA, Leach KL, Jeng AY, Yeh E (1984) Mechanism of action of the phorbol ester tumor promoters: Specific receptors for lipophilic ligands. Biochem Pharmacol 33:933-940
-
(1984)
Biochem Pharmacol
, vol.33
, pp. 933-940
-
-
Blumberg, P.M.1
Jaken, S.2
Konig, B.3
Sharkey, N.A.4
Leach, K.L.5
Jeng, A.Y.6
Yeh, E.7
-
163
-
-
0037134482
-
Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives
-
Watanabe H, Davis JB, Smart D, Jerman JC, Smith GD, Hayes P, Vriens J, Cairns W, Wissenbach U, Prenen J, Flockerzi V, Droogmans G, Benham CD, Nilius B (2002) Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem 277:13569-13577
-
(2002)
J Biol Chem
, vol.277
, pp. 13569-13577
-
-
Watanabe, H.1
Davis, J.B.2
Smart, D.3
Jerman, J.C.4
Smith, G.D.5
Hayes, P.6
Vriens, J.7
Cairns, W.8
Wissenbach, U.9
Prenen, J.10
Flockerzi, V.11
Droogmans, G.12
Benham, C.D.13
Nilius, B.14
-
164
-
-
65649150431
-
Modulation of the transient receptor potential vanilloid channel TRPV4 by 4alpha-phorbol esters: A structure-activity study
-
Klausen TK, Pagani A, Minassi A, Ech-Chahad A, Prenen J, Owsianik G, Hoffmann EK, Pedersen SF, Appendino G, Nilius B (2009) Modulation of the transient receptor potential vanilloid channel TRPV4 by 4alpha-phorbol esters: A structure-activity study. J Med Chem 52:2933-2939
-
(2009)
J Med Chem
, vol.52
, pp. 2933-2939
-
-
Klausen, T.K.1
Pagani, A.2
Minassi, A.3
Ech-Chahad, A.4
Prenen, J.5
Owsianik, G.6
Hoffmann, E.K.7
Pedersen, S.F.8
Appendino, G.9
Nilius, B.10
-
165
-
-
0347719316
-
Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4
-
Vriens J, Watanabe H, Janssens A, Droogmans G, Voets T, Nilius B (2004) Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4. Proc Natl Acad Sci USA 101:396-401
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 396-401
-
-
Vriens, J.1
Watanabe, H.2
Janssens, A.3
Droogmans, G.4
Voets, T.5
Nilius, B.6
-
166
-
-
0043267987
-
Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels
-
Watanabe H, Vriens J, Prenen J, Droogmans G, Voets T, Nilius B (2003) Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels. Nature 424:434-438
-
(2003)
Nature
, vol.424
, pp. 434-438
-
-
Watanabe, H.1
Vriens, J.2
Prenen, J.3
Droogmans, G.4
Voets, T.5
Nilius, B.6
-
167
-
-
0035328671
-
Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins
-
Tsavaler L, Shapero MH, Morkowski S, Laus R (2001) Trp-p8, a novel prostate-specific gene, is up-regulated in prostate cancer and other malignancies and shares high homology with transient receptor potential calcium channel proteins. Cancer Res 61:3760-3769
-
(2001)
Cancer Res
, vol.61
, pp. 3760-3769
-
-
Tsavaler, L.1
Shapero, M.H.2
Morkowski, S.3
Laus, R.4
-
168
-
-
33646556404
-
Tissue distribution profiles of the human TRPM cation channel family
-
Fonfria E, Murdock PR, Cusdin FS, Benham CD, Kelsell RE, McNulty S (2006) Tissue distribution profiles of the human TRPM cation channel family. J Recept Signal Transduct Res 26:159-178
-
(2006)
J Recept Signal Transduct Res
, vol.26
, pp. 159-178
-
-
Fonfria, E.1
Murdock, P.R.2
Cusdin, F.S.3
Benham, C.D.4
Kelsell, R.E.5
McNulty, S.6
-
169
-
-
33947515995
-
Modulation of the cold-activated channel TRPM8 by lysophospholipids and polyunsaturated fatty acids
-
Andersson DA, Nash M, Bevan S (2007) Modulation of the cold-activated channel TRPM8 by lysophospholipids and polyunsaturated fatty acids. J Neurosci 27:3347-3355
-
(2007)
J Neurosci
, vol.27
, pp. 3347-3355
-
-
Andersson, D.A.1
Nash, M.2
Bevan, S.3
-
170
-
-
33845979165
-
Ca2+-independent phospholipase A2- dependent gating of TRPM8 by lysophospholipids
-
Vanden Abeele F, Zholos A, Bidaux G, Shuba Y, Thebault S, Beck B, Flourakis M, Panchin Y, Skryma R, Prevarskaya N (2006) Ca2+-independent phospholipase A2- dependent gating of TRPM8 by lysophospholipids. J Biol Chem 281:40174-40182
-
(2006)
J Biol Chem
, vol.281
, pp. 40174-40182
-
-
Vanden Abeele, F.1
Zholos, A.2
Bidaux, G.3
Shuba, Y.4
Thebault, S.5
Beck, B.6
Flourakis, M.7
Panchin, Y.8
Skryma, R.9
Prevarskaya, N.10
-
171
-
-
14944348415
-
Activation of the melastatin-related cation channel TRPM3 by D-erythro-sphingosine [corrected]
-
Grimm C, Kraft R, Schultz G, Harteneck C (2005) Activation of the melastatin-related cation channel TRPM3 by D-erythro-sphingosine [corrected]. Mol Pharmacol 67:798-805
-
(2005)
Mol Pharmacol
, vol.67
, pp. 798-805
-
-
Grimm, C.1
Kraft, R.2
Schultz, G.3
Harteneck, C.4
-
172
-
-
57049164233
-
Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells
-
Wagner TF, Loch S, Lambert S, Straub I, Mannebach S, Mathar I, Dufer M, Lis A, Flockerzi V, Philipp SE, Oberwinkler J (2008) Transient receptor potential M3 channels are ionotropic steroid receptors in pancreatic beta cells. Nat Cell Biol 10:1421-1430
-
(2008)
Nat Cell Biol
, vol.10
, pp. 1421-1430
-
-
Wagner, T.F.1
Loch, S.2
Lambert, S.3
Straub, I.4
Mannebach, S.5
Mathar, I.6
Dufer, M.7
Lis, A.8
Flockerzi, V.9
Philipp, S.E.10
Oberwinkler, J.11
-
173
-
-
18244391511
-
LTRPC2 Ca2+- permeable channel activated by changes in redox status confers susceptibility to cell death
-
Hara Y, Wakamori M, Ishii M, Maeno E, Nishida M, Yoshida T, Yamada H, Shimizu S, Mori E, Kudoh J, Shimizu N, Kurose H, Okada Y, Imoto K, Mori Y (2002) LTRPC2 Ca2+- permeable channel activated by changes in redox status confers susceptibility to cell death. Mol Cell 9:163-173
-
(2002)
Mol Cell
, vol.9
, pp. 163-173
-
-
Hara, Y.1
Wakamori, M.2
Ishii, M.3
Maeno, E.4
Nishida, M.5
Yoshida, T.6
Yamada, H.7
Shimizu, S.8
Mori, E.9
Kudoh, J.10
Shimizu, N.11
Kurose, H.12
Okada, Y.13
Imoto, K.14
Mori, Y.15
-
174
-
-
33646543034
-
TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion
-
Togashi K, Hara Y, Tominaga T, Higashi T, Konishi Y, Mori Y, Tominaga M (2006) TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion. Embo J 25:1804-1815
-
(2006)
Embo J
, vol.25
, pp. 1804-1815
-
-
Togashi, K.1
Hara, Y.2
Tominaga, T.3
Higashi, T.4
Konishi, Y.5
Mori, Y.6
Tominaga, M.7
-
175
-
-
33845602018
-
Nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose regulate TRPM2 channels in T lymphocytes
-
Beck A, Kolisek M, Bagley LA, Fleig A, Penner R (2006) Nicotinic acid adenine dinucleotide phosphate and cyclic ADP-ribose regulate TRPM2 channels in T lymphocytes. Faseb J 20:962-964
-
(2006)
Faseb J
, vol.20
, pp. 962-964
-
-
Beck, A.1
Kolisek, M.2
Bagley, L.A.3
Fleig, A.4
Penner, R.5
-
176
-
-
33744483084
-
Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid
-
Kraft R, Grimm C, Frenzel H, Harteneck C (2006) Inhibition of TRPM2 cation channels by N-(p-amylcinnamoyl)anthranilic acid. Br J Pharmacol 148:264-273
-
(2006)
Br J Pharmacol
, vol.148
, pp. 264-273
-
-
Kraft, R.1
Grimm, C.2
Frenzel, H.3
Harteneck, C.4
-
177
-
-
12444304491
-
Comparison of functional properties of the Ca2+-activated cation channels TRPM4 and TRPM5 from mice
-
Ullrich ND, Voets T, Prenen J, Vennekens R, Talavera K, Droogmans G, Nilius B (2005) Comparison of functional properties of the Ca2+-activated cation channels TRPM4 and TRPM5 from mice. Cell Calcium 37:267-278
-
(2005)
Cell Calcium
, vol.37
, pp. 267-278
-
-
Ullrich, N.D.1
Voets, T.2
Prenen, J.3
Vennekens, R.4
Talavera, K.5
Droogmans, G.6
Nilius, B.7
-
178
-
-
42149169648
-
9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels
-
Grand T, Demion M, Norez C, Mettey Y, Launay P, Becq F, Bois P, Guinamard R (2008) 9-phenanthrol inhibits human TRPM4 but not TRPM5 cationic channels. Br J Pharmacol 153:1697-1705
-
(2008)
Br J Pharmacol
, vol.153
, pp. 1697-1705
-
-
Grand, T.1
Demion, M.2
Norez, C.3
Mettey, Y.4
Launay, P.5
Becq, F.6
Bois, P.7
Guinamard, R.8
-
179
-
-
7244250645
-
Decavanadate modulates gating of TRPM4 cation channels
-
Nilius B, Prenen J, Janssens A, Voets T, Droogmans G (2004) Decavanadate modulates gating of TRPM4 cation channels. J Physiol 560:753-765
-
(2004)
J Physiol
, vol.560
, pp. 753-765
-
-
Nilius, B.1
Prenen, J.2
Janssens, A.3
Voets, T.4
Droogmans, G.5
-
180
-
-
0345616438
-
ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures
-
Story GM, Peier AM, Reeve AJ, Eid SR, Mosbacher J, Hricik TR, Earley TJ, Hergarden AC, Andersson DA, Hwang SW, McIntyre P, Jegla T, Bevan S, Patapoutian A (2003) ANKTM1, a TRP-like channel expressed in nociceptive neurons, is activated by cold temperatures. Cell 112:819-829
-
(2003)
Cell
, vol.112
, pp. 819-829
-
-
Story, G.M.1
Peier, A.M.2
Reeve, A.J.3
Eid, S.R.4
Mosbacher, J.5
Hricik, T.R.6
Earley, T.J.7
Hergarden, A.C.8
Andersson, D.A.9
Hwang, S.W.10
McIntyre, P.11
Jegla, T.12
Bevan, S.13
Patapoutian, A.14
-
181
-
-
71449090476
-
TRPA1 modulators in preclinical development
-
Viana F, Ferrer-Montiel A (2009) TRPA1 modulators in preclinical development. Expert Opin Ther Pat 19:1787-1799
-
(2009)
Expert Opin Ther Pat
, vol.19
, pp. 1787-1799
-
-
Viana, F.1
Ferrer-Montiel, A.2
-
182
-
-
76349099584
-
The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation
-
da Costa DS, Meotti FC, Andrade EL, Leal PC, Motta EM, Calixto JB (2010) The involvement of the transient receptor potential A1 (TRPA1) in the maintenance of mechanical and cold hyperalgesia in persistent inflammation. Pain 148:431-437
-
(2010)
Pain
, vol.148
, pp. 431-437
-
-
Da Costa, D.S.1
Meotti, F.C.2
Andrade, E.L.3
Leal, P.C.4
Motta, E.M.5
Calixto, J.B.6
-
183
-
-
70749118691
-
The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli
-
Brierley SM, Hughes PA, Page AJ, Kwan KY, Martin CM, O'Donnell TA, Cooper NJ, Harrington AM, Adam B, Liebregts T, Holtmann G, Corey DP, Rychkov GY, Blackshaw LA (2009) The ion channel TRPA1 is required for normal mechanosensation and is modulated by algesic stimuli. Gastroenterology 137:2084-2095
-
(2009)
Gastroenterology
, vol.137
, pp. 2084-2095
-
-
Brierley, S.M.1
Hughes, P.A.2
Page, A.J.3
Kwan, K.Y.4
Martin, C.M.5
O'Donnell, T.A.6
Cooper, N.J.7
Harrington, A.M.8
Adam, B.9
Liebregts, T.10
Holtmann, G.11
Corey, D.P.12
Rychkov, G.Y.13
Blackshaw, L.A.14
-
184
-
-
67650085850
-
Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals
-
Wei H, Hamalainen MM, Saarnilehto M, Koivisto A, Pertovaara A (2009) Attenuation of mechanical hypersensitivity by an antagonist of the TRPA1 ion channel in diabetic animals. Anesthesiology 111:147-154
-
(2009)
Anesthesiology
, vol.111
, pp. 147-154
-
-
Wei, H.1
Hamalainen, M.M.2
Saarnilehto, M.3
Koivisto, A.4
Pertovaara, A.5
-
185
-
-
33646061333
-
TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction
-
Kwan KY, Allchorne AJ, Vollrath MA, Christensen AP, Zhang DS, Woolf CJ, Corey DP (2006) TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction. Neuron 50:277-289
-
(2006)
Neuron
, vol.50
, pp. 277-289
-
-
Kwan, K.Y.1
Allchorne, A.J.2
Vollrath, M.A.3
Christensen, A.P.4
Zhang, D.S.5
Woolf, C.J.6
Corey, D.P.7
-
186
-
-
34548101399
-
TRPA1 mediates formalin-induced pain
-
McNamara CR, Mandel-Brehm J, Bautista DM, Siemens J, Deranian KL, Zhao M, Hayward NJ, Chong JA, Julius D, Moran MM, Fanger CM (2007) TRPA1 mediates formalin-induced pain. Proc Natl Acad Sci USA 104:13525-13530
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 13525-13530
-
-
McNamara, C.R.1
Mandel-Brehm, J.2
Bautista, D.M.3
Siemens, J.4
Deranian, K.L.5
Zhao, M.6
Hayward, N.J.7
Chong, J.A.8
Julius, D.9
Moran, M.M.10
Fanger, C.M.11
-
187
-
-
64049103386
-
Diallyl sulfides in garlic activate both TRPA1 and TRPV1
-
Koizumi K, Iwasaki Y, Narukawa M, Iitsuka Y, Fukao T, Seki T, Ariga T,Watanabe T (2009) Diallyl sulfides in garlic activate both TRPA1 and TRPV1. Biochem Biophys Res Commun 382:545-548
-
(2009)
Biochem Biophys Res Commun
, vol.382
, pp. 545-548
-
-
Koizumi, K.1
Iwasaki, Y.2
Narukawa, M.3
Iitsuka, Y.4
Fukao, T.5
Seki, T.6
Ariga, T.7
Watanabe, T.8
-
188
-
-
59849114038
-
Pore dilation occurs in TRPA1 but not in TRPM8 channels
-
Chen J, Kim D, Bianchi BR, Cavanaugh EJ, Faltynek CR, Kym PR, Reilly RM (2009) Pore dilation occurs in TRPA1 but not in TRPM8 channels. Mol Pain 5:3
-
(2009)
Mol Pain
, vol.5
, pp. 3
-
-
Chen, J.1
Kim, D.2
Bianchi, B.R.3
Cavanaugh, E.J.4
Faltynek, C.R.5
Kym, P.R.6
Reilly, R.M.7
-
190
-
-
33846692923
-
Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines
-
Macpherson LJ, Dubin AE, Evans MJ, Marr F, Schultz PG, Cravatt BF, Patapoutian A (2007) Noxious compounds activate TRPA1 ion channels through covalent modification of cysteines. Nature 445:541-545
-
(2007)
Nature
, vol.445
, pp. 541-545
-
-
Macpherson, L.J.1
Dubin, A.E.2
Evans, M.J.3
Marr, F.4
Schultz, P.G.5
Cravatt, B.F.6
Patapoutian, A.7
-
191
-
-
24744446008
-
Pungent products from garlic activate the sensory ion channel TRPA1
-
Bautista DM, Movahed P, Hinman A, Axelsson HE, Sterner O, Hogestatt ED, Julius D, Jordt SE, Zygmunt PM (2005) Pungent products from garlic activate the sensory ion channel TRPA1. Proc Natl Acad Sci USA 102:12248-12252
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 12248-12252
-
-
Bautista, D.M.1
Movahed, P.2
Hinman, A.3
Axelsson, H.E.4
Sterner, O.5
Hogestatt, E.D.6
Julius, D.7
Jordt, S.E.8
Zygmunt, P.M.9
-
192
-
-
73249139452
-
Enhanced activation of the transient receptor potential channel TRPA1 by ajoene, an allicin derivative
-
Yassaka RT, Inagaki H, Fujino T, Nakatani K, Kubo T (2010) Enhanced activation of the transient receptor potential channel TRPA1 by ajoene, an allicin derivative. Neurosci Res 66:99-105
-
(2010)
Neurosci Res
, vol.66
, pp. 99-105
-
-
Yassaka, R.T.1
Inagaki, H.2
Fujino, T.3
Nakatani, K.4
Kubo, T.5
-
193
-
-
46749091281
-
Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents
-
Andre E, Campi B, Materazzi S, Trevisani M, Amadesi S, Massi D, Creminon C, Vaksman N, Nassini R, Civelli M, Baraldi PG, Poole DP, Bunnett NW, Geppetti P, Patacchini R (2008) Cigarette smoke-induced neurogenic inflammation is mediated by alpha,beta-unsaturated aldehydes and the TRPA1 receptor in rodents. J Clin Invest 118: 2574-2582
-
(2008)
J Clin Invest
, vol.118
, pp. 2574-2582
-
-
Andre, E.1
Campi, B.2
Materazzi, S.3
Trevisani, M.4
Amadesi, S.5
Massi, D.6
Creminon, C.7
Vaksman, N.8
Nassini, R.9
Civelli, M.10
Baraldi, P.G.11
Poole, D.P.12
Bunnett, N.W.13
Geppetti, P.14
Patacchini, R.15
-
194
-
-
34548094044
-
4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1
-
Trevisani M, Siemens J, Materazzi S, Bautista DM, Nassini R, Campi B, Imamachi N, Andre E, Patacchini R, Cottrell GS, Gatti R, Basbaum AI, Bunnett NW, Julius D, Geppetti P (2007) 4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1. Proc Natl Acad Sci USA 104:13519-13524
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 13519-13524
-
-
Trevisani, M.1
Siemens, J.2
Materazzi, S.3
Bautista, D.M.4
Nassini, R.5
Campi, B.6
Imamachi, N.7
Andre, E.8
Patacchini, R.9
Cottrell, G.S.10
Gatti, R.11
Basbaum, A.I.12
Bunnett, N.W.13
Julius, D.14
Geppetti, P.15
-
195
-
-
35748933471
-
Transient receptor potential A1 mediates acetaldehyde-evoked pain sensation
-
Bang S, Kim KY, Yoo S, Kim YG, Hwang SW (2007) Transient receptor potential A1 mediates acetaldehyde-evoked pain sensation. Eur J Neurosci 26:2516-2523
-
(2007)
Eur J Neurosci
, vol.26
, pp. 2516-2523
-
-
Bang, S.1
Kim, K.Y.2
Yoo, S.3
Kim, Y.G.4
Hwang, S.W.5
-
196
-
-
0036617759
-
Delta 9-tetrahydrocannabinol and cannabinol activate capsaicin-sensitive sensory nerves via a CB1 and CB2 cannabinoid receptor-independent mechanism
-
Zygmunt PM, Andersson DA, Hogestatt ED (2002) Delta 9- tetrahydrocannabinol and cannabinol activate capsaicin-sensitive sensory nerves via a CB1 and CB2 cannabinoid receptor-independent mechanism. J Neurosci 22:4720-4727
-
(2002)
J Neurosci
, vol.22
, pp. 4720-4727
-
-
Zygmunt, P.M.1
Andersson, D.A.2
Hogestatt, E.D.3
-
197
-
-
18444376760
-
International Union of Pharmacology. XXVII. Classification of cannabinoid receptors
-
Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, Devane WA, Felder CC, Herkenham M, Mackie K, Martin BR, Mechoulam R, Pertwee RG (2002) International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol Rev 54:161-202
-
(2002)
Pharmacol Rev
, vol.54
, pp. 161-202
-
-
Howlett, A.C.1
Barth, F.2
Bonner, T.I.3
Cabral, G.4
Casellas, P.5
Devane, W.A.6
Felder, C.C.7
Herkenham, M.8
Mackie, K.9
Martin, B.R.10
Mechoulam, R.11
Pertwee, R.G.12
-
198
-
-
45849089128
-
Activation of transient receptor potential A1 channels by mustard oil, tetrahydrocannabinol and Ca2+ reveals different functional channel states
-
Cavanaugh EJ, Simkin D, Kim D (2008) Activation of transient receptor potential A1 channels by mustard oil, tetrahydrocannabinol and Ca2+ reveals different functional channel states. Neuroscience 154:1467-1476
-
(2008)
Neuroscience
, vol.154
, pp. 1467-1476
-
-
Cavanaugh, E.J.1
Simkin, D.2
Kim, D.3
-
199
-
-
34548309115
-
Hydroxyalpha- sanshool activates TRPV1 and TRPA1 in sensory neurons
-
Koo JY, Jang Y, Cho H, Lee CH, Jang KH, Chang YH, Shin J, Oh U (2007) Hydroxyalpha- sanshool activates TRPV1 and TRPA1 in sensory neurons. Eur J Neurosci 26: 1139-1147
-
(2007)
Eur J Neurosci
, vol.26
, pp. 1139-1147
-
-
Koo, J.Y.1
Jang, Y.2
Cho, H.3
Lee, C.H.4
Jang, K.H.5
Chang, Y.H.6
Shin, J.7
Oh, U.8
-
200
-
-
70349559585
-
Nicotine activates the chemosensory cation channel TRPA1
-
Talavera K, Gees M, Karashima Y, Meseguer VM, Vanoirbeek JA, Damann N, Everaerts W, Benoit M, Janssens A, Vennekens R, Viana F, Nemery B, Nilius B, Voets T (2009) Nicotine activates the chemosensory cation channel TRPA1. Nat Neurosci 12:1293-1299
-
(2009)
Nat Neurosci
, vol.12
, pp. 1293-1299
-
-
Talavera, K.1
Gees, M.2
Karashima, Y.3
Meseguer, V.M.4
Vanoirbeek, J.A.5
Damann, N.6
Everaerts, W.7
Benoit, M.8
Janssens, A.9
Vennekens, R.10
Viana, F.11
Nemery, B.12
Nilius, B.13
Voets, T.14
-
201
-
-
49749134635
-
Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1
-
Cruz-Orengo L, Dhaka A, Heuermann RJ, Young TJ, Montana MC, Cavanaugh EJ, Kim D, Story GM (2008) Cutaneous nociception evoked by 15-delta PGJ2 via activation of ion channel TRPA1. Mol Pain 4:30
-
(2008)
Mol Pain
, vol.4
, pp. 30
-
-
Cruz-Orengo, L.1
Dhaka, A.2
Heuermann, R.J.3
Young, T.J.4
Montana, M.C.5
Cavanaugh, E.J.6
Kim, D.7
Story, G.M.8
-
202
-
-
0042206600
-
Regulation of canonical transient receptor potential (TRPC) channel function by diacylglycerol and protein kinase C
-
Venkatachalam K, Zheng F, Gill DL (2003) Regulation of canonical transient receptor potential (TRPC) channel function by diacylglycerol and protein kinase C. J. Biol. Chem 278:29031-29040
-
(2003)
J. Biol. Chem
, vol.278
, pp. 29031-29040
-
-
Venkatachalam, K.1
Zheng, F.2
Gill, D.L.3
-
203
-
-
0034752902
-
Activation of inositol 1,4,5-trisphosphate receptor is essential for the opening of mouse TRP5 channel
-
Kanki H, Kinoshita M, Akaike A, Satoh M, Mori Y, Kaneko S (2001) Activation of inositol 1,4,5-trisphosphate receptor is essential for the opening of mouse TRP5 channel. Mol Pharmacol 60:989-998
-
(2001)
Mol Pharmacol
, vol.60
, pp. 989-998
-
-
Kanki, H.1
Kinoshita, M.2
Akaike, A.3
Satoh, M.4
Mori, Y.5
Kaneko, S.6
-
204
-
-
0034103610
-
Identification of a peptide toxin from Grammastola spatulata spider venom that blocks cation-selective stretch-activated channels
-
Suchyna TM, Johnson JH, Hamer K, Leykam JF, Gage DA, Clemo HF, Baumgarten CM, Sachs F (2000) Identification of a peptide toxin from Grammastola spatulata spider venom that blocks cation-selective stretch-activated channels. J Gen Physiol 115:583-598
-
(2000)
J Gen Physiol
, vol.115
, pp. 583-598
-
-
Suchyna, T.M.1
Johnson, J.H.2
Hamer, K.3
Leykam, J.F.4
Gage, D.A.5
Clemo, H.F.6
Baumgarten, C.M.7
Sachs, F.8
-
205
-
-
33748305857
-
The mechanosensitive TRPC1 ion channel activity is modulated by cytoskeleton and inhibited by the peptide GsMTx4
-
Gottlieb P, Suchyna TM, Bowman CL, Sachs F (2006) The mechanosensitive TRPC1 ion channel activity is modulated by cytoskeleton and inhibited by the peptide GsMTx4. Biophys J 90:1545
-
(2006)
Biophys J
, vol.90
, pp. 1545
-
-
Gottlieb, P.1
Suchyna, T.M.2
Bowman, C.L.3
Sachs, F.4
-
206
-
-
33750802650
-
A common mechanism underlies stretch activation and receptor activation of TRPC6 channels
-
Spassova MA, Hewavitharana T, Xu W, Sobloff J, Gill DL (2006) A common mechanism underlies stretch activation and receptor activation of TRPC6 channels. Proc Natl Acad Sci USA 103:16586-16591
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 16586-16591
-
-
Spassova, M.A.1
Hewavitharana, T.2
Xu, W.3
Sobloff, J.4
Gill, D.L.5
-
207
-
-
57049153922
-
Hypoosmotic- and pressure-induced membrane stretch activate TRPC5 channels
-
Gomis A, Soriano S, Belmonte C, Viana F (2008) Hypoosmotic- and pressure-induced membrane stretch activate TRPC5 channels. J Physiol 586:5633-5649
-
(2008)
J Physiol
, vol.586
, pp. 5633-5649
-
-
Gomis, A.1
Soriano, S.2
Belmonte, C.3
Viana, F.4
-
208
-
-
34948844247
-
High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain
-
Drew LJ, Rugiero F, Cesare P, Gale JE, Abrahamsen B, Bowden S, Heinzmann S, Robinson M, Brust A, Colless B, Lewis RJ,Wood JD (2007) High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain. PLoS One 2:e515
-
(2007)
PLoS One
, vol.2
-
-
Drew, L.J.1
Rugiero, F.2
Cesare, P.3
Gale, J.E.4
Abrahamsen, B.5
Bowden, S.6
Heinzmann, S.7
Robinson, M.8
Brust, A.9
Colless, B.10
Lewis, R.J.11
Wood, J.D.12
-
209
-
-
77149175638
-
Simple 2,4- diacylphloroglucinols as classic transient receptor potential-6 activators - identification of a novel pharmacophore
-
Leuner K, Heiser JH, Derksen S, Mladenov MI, Fehske CJ, Schubert R, Gollasch M, Schneider G, Hartenecj C, Chatterjee SS, Muller WE (2010) Simple 2,4- diacylphloroglucinols as classic transient receptor potential-6 activators - identification of a novel pharmacophore. Mol Pharmacol 77:368-377
-
(2010)
Mol Pharmacol
, vol.77
, pp. 368-377
-
-
Leuner, K.1
Heiser, J.H.2
Derksen, S.3
Mladenov, M.I.4
Fehske, C.J.5
Schubert, R.6
Gollasch, M.7
Schneider, G.8
Hartenecj, C.9
Chatterjee, S.S.10
Muller, W.E.11
-
210
-
-
0041856188
-
20-hydroxyeicosatetraenoic acid (20-HETE) activates mouse TRPC6 channels expressed in HEK293 cells
-
Basora N, Boulay G, Bilodeau L, Rousseau E, PayetMD (2003) 20-hydroxyeicosatetraenoic acid (20-HETE) activates mouse TRPC6 channels expressed in HEK293 cells. J Biol Chem 278:31709-31716
-
(2003)
J Biol Chem
, vol.278
, pp. 31709-31716
-
-
Basora, N.1
Boulay, G.2
Bilodeau, L.3
Rousseau, E.4
Payet, M.D.5
-
211
-
-
34248350004
-
Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease
-
Leuenroth SJ, Okuhara D, Shotwell JD, Markowitz GS, Yu Z, Somlo S, Crews CM (2007) Triptolide is a traditional Chinese medicine-derived inhibitor of polycystic kidney disease. Proc Natl Acad Sci USA 104:4389-4394
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 4389-4394
-
-
Leuenroth, S.J.1
Okuhara, D.2
Shotwell, J.D.3
Markowitz, G.S.4
Yu, Z.5
Somlo, S.6
Crews, C.M.7
-
213
-
-
34547521545
-
TRP channels in disease
-
Nilius B (2007) TRP channels in disease. Biochim Biophys Acta 1772:805-812
-
(2007)
Biochim Biophys Acta
, vol.1772
, pp. 805-812
-
-
Nilius, B.1
-
214
-
-
77955569436
-
Transient receptor potential channelopathies
-
Nilius B, Owsianik G (2010) Transient receptor potential channelopathies. Pflugers Arch 460(2):437-450.
-
(2010)
Pflugers Arch
, vol.460
, Issue.2
, pp. 437-450
-
-
Nilius, B.1
Owsianik, G.2
-
216
-
-
33644826318
-
Pharmacological characterisation of the plant sesquiterpenes polygodial and drimanial as vanilloid receptor agonists
-
Andre E, Campi B, Trevisani M, Ferreira J, Malheiros A, Yunes RA, Calixto JB, Geppetti P (2006) Pharmacological characterisation of the plant sesquiterpenes polygodial and drimanial as vanilloid receptor agonists. Biochem Pharmacol 71:1248-1254
-
(2006)
Biochem Pharmacol
, vol.71
, pp. 1248-1254
-
-
Andre, E.1
Campi, B.2
Trevisani, M.3
Ferreira, J.4
Malheiros, A.5
Yunes, R.A.6
Calixto, J.B.7
Geppetti, P.8
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