The receptors for mammalian sweet and umami taste

Cell

Volumn 115, Issue 3, 2003, Pages 255-266

  Zhao, Grace Q ^a   Zhang, Yifeng ^a   Hoon, Mark A ^b   Chandrashekar, Jayaram ^a   Erlenbach, Isolde ^b   Ryba, Nicholas J P ^b   Zuker, Charles S ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; GLUTAMATE SODIUM; GUANINE NUCLEOTIDE BINDING PROTEIN; OPIATE RECEPTOR; PROTEIN SUBUNIT; RECEPTOR SUBTYPE; T1R RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; BEHAVIOR; CODING; COMPLEX FORMATION; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PERCEPTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECOGNITION; SWEETNESS; TASTE; TASTE BUD; TASTE PREFERENCE;

ANIMALIA; MAMMALIA; STAPHYLOCOCCUS PHAGE 3A;

EID: 0344823647     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(03)00844-4     Document Type: Article

References (41)

1. Abaffy T., Trubey K.R., Chaudhari N. Adenylyl cyclase expression and modulation of cAMP in rat taste cells. Am. J. Physiol. Cell Physiol. 284:2003;C1420-C1428.
2. Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P., Zuker C.S. A novel family of mammalian taste receptors. Cell. 100:2000;693-702.
3. Bachmanov A.A., Tordoff M.G., Beauchamp G.K. Intake of umami-tasting solutions by mice. a genetic analysis J. Nutr. 130:2000;935S-941S.
4. Bufe B., Hofmann T., Krautwurst D., Raguse J.D., Meyerhof W. The human TAS2R16 receptor mediates bitter taste in response to β-glucopyranosides. Nat. Genet. 32:2002;397-401.
5. Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W., Zuker C.S., Ryba N.J.P. T2Rs function as bitter taste receptors. Cell. 100:2000;703-711.
6. Chaudhari N., Roper S.D. Molecular and physiological evidence for glutamate (umami) taste transduction via a G protein-coupled receptor. Ann. N Y Acad. Sci. 855:1998;398-406.
7. Chaudhari N., Yang H., Lamp C., Delay E., Cartford C., Than T., Roper S. The taste of monosodium glutamate. membrane receptors in taste buds J. Neurosci. 16:1996;3817-3826.
8. Chaudhari N., Landin A.M., Roper S.D. A metabotropic glutamate receptor variant functions as a taste receptor. Nat. Neurosci. 3:2000;113-119.
9. Dahl M., Erickson R.P., Simon S.A. Neural responses to bitter compounds in rats. Brain Res. 756:1997;22-34.
10. Damak S., Rong M., Yasumatsu K., Kokrashvili Z., Varadarajan V., Zou S., Jiang P., Ninomiya Y., Margolskee R.F. Detection of sweet and umami taste in the absence of taste receptor T1r3. Science. 301:2003;850-853.
11. Danilova V., Hellekant G. Comparison of the responses of the chorda tympani and glossopharyngeal nerves to taste stimuli in C57BL/6J mice. BMC Neurosci. 4:2003;5.
12. Danilova V., Hellekant G., Tinti J.M., Nofre C. Gustatory responses of the hamster Mesocricetus auratus to various compounds considered sweet by humans. J. Neurophysiol. 80:1998;2102-2112.
13. Glendinning J.I., Gresack J., Spector A.C. A high-throughput screening procedure for identifying mice with aberrant taste and oromotor function. Chem. Senses. 27:2002;461-474.
14. Gogos J.A., Osborne J., Nemes A., Mendelsohn M., Axel R. Genetic ablation and restoration of the olfactory topographic map. Cell. 103:2000;609-620.
15. Gossen M., Bonin A.L., Freundlieb S., Bujard H. Inducible gene expression systems for higher eukaryotic cells. Curr. Opin. Biotechnol. 5:1994;516-520.
16. Hoon M.A., Adler E., Lindemeier J., Battey J.F., Ryba N.J.P., Zuker C.S. Putative mammalian taste receptors. a class of taste-specific GPCRs with distinct topographic selectivity Cell. 96:1999;541-551.
17. Kinnamon S.C. A plethora of taste receptors. Neuron. 25:2000;507-510.
18. Kitagawa M., Kusakabe Y., Miura H., Ninomiya Y., Hino A. Molecular genetic identification of a candidate receptor gene for sweet taste. Biochem. Biophys. Res. Commun. 283:2001;236-242.
19. Kunishima N., Shimada Y., Tsuji Y., Sato T., Yamamoto M., Kumasaka T., Nakanishi S., Jingami H., Morikawa K. Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature. 407:2000;971-977.
20. Li X., Staszewski L., Xu H., Durick K., Zoller M., Adler E. Human receptors for sweet and umami taste. Proc. Natl. Acad. Sci. USA. 99:2002;4692-4696.
21. Lindemann B. Taste reception. Physiol. Rev. 76:1996;718-766.
22. Maga J.A. Flavor potentiators. Crit. Rev. Food Sci. Nutr. 18:1983;231-312.
23. Margolskee R.F. Molecular mechanisms of bitter and sweet taste transduction. J. Biol. Chem. 277:2002;1-4.
24. Matsunami H., Montmayeur J.P., Buck L.B. A family of candidate taste receptors in human and mouse. Nature. 404:2000;601-604.
25. Max M., Shanker Y.G., Huang L., Rong M., Liu Z., Campagne F., Weinstein H., Damak S., Margolskee R.F. Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. Nat. Genet. 28:2001;58-63.
26. McLaughlin S.K., McKinnon P.J., Margolskee R.F. Gustducin is a taste-cell-specific G protein closely related to the transducins. Nature. 357:1992;563-569.
27. Mody S.M., Ho M.K., Joshi S.A., Wong Y.H. Incorporation of Galpha(z)-specific sequence at the carboxyl terminus increases the promiscuity of galpha(16) toward G(i)-coupled receptors. Mol. Pharmacol. 57:2000;13-23.
28. Montmayeur J.P., Liberles S.D., Matsunami H., Buck L.B. A candidate taste receptor gene near a sweet taste locus. Nat. Neurosci. 4:2001;492-498.
29. Nelson G., Hoon M.A., Chandrashekar J., Zhang Y., Ryba N.J.P., Zuker C.S. Mammalian sweet taste receptors. Cell. 106:2001;381-390.
30. Nelson G., Chandrashekar J., Hoon M.A., Feng L., Zhao G., Ryba N.J., Zuker C.S. An amino-acid taste receptor. Nature. 416:2002;199-202.
31. Ninomiya Y., Imoto T., Sugimura T. Sweet taste responses of mouse chorda tympani neurons. existence of gurmarin-sensitive and -insensitive receptor components J. Neurophysiol. 81:1999;3087-3091.
32. Offermanns S., Simon M.I. G alpha 15 and G alpha 16 couple a wide variety of receptors to phospholipase C. J. Biol. Chem. 270:1995;15175-15180.
33. Perez C.A., Huang L., Rong M., Kozak J.A., Preuss A.K., Zhang H., Max M., Margolskee R.F. A transient receptor potential channel expressed in taste receptor cells. Nat. Neurosci. 5:2002;1169-1176.
34. Redfern C.H., Coward P., Degtyarev M.Y., Lee E.K., Kwa A.T., Hennighausen L., Bujard H., Fishman G.I., Conklin B.R. Conditional expression and signaling of a specifically designed Gi-coupled receptor in transgenic mice. Nat. Biotechnol. 17:1999;165-169.
35. Rossler P., Kroner C., Freitag J., Noe J., Breer H. Identification of a phospholipase Cβ beta subtype in rat taste cells. Eur. J. Cell Biol. 77:1998;253-261.
36. Sainz E., Korley J.N., Battey J.F., Sullivan S.L. Identification of a novel member of the T1R family of putative taste receptors. J. Neurochem. 77:2001;896-903.
37. Schiffman S.S., Cahn H., Lindley M.G. Multiple receptor sites mediate sweetness. evidence from cross adaptation Pharmacol. Biochem. Behav. 15:1981;377-388.
38. Troemel E.R., Kimmel B.E., Bargmann C.I. Reprogramming chemotaxis responses. sensory neurons define olfactory preferences in C. elegans Cell. 91:1997;161-169.
39. Yoshii K., Yokouchi C., Kurihara K. Synergistic effects of 5′-nucleotides on rat taste responses to various amino acids. Brain Res. 367:1986;45-51.
40. Zack D.J., Bennett J., Wang Y., Davenport C., Klaunberg B., Gearhart J., Nathans J. Unusual topography of bovine rhodopsin promoter-lacZ fusion gene expression in transgenic mouse retinas. Neuron. 6:1991;187-199.
41. Zhang Y., Hoon M.A., Chandrashekar J., Mueller K.L., Cook B., Wu D., Zuker C.S., Ryba N.J.P. Coding of sweet, bitter, and umami tastes. different receptor cells sharing similar signaling pathways Cell. 112:2003;293-301.