Regulation of adipogenesis by quinine through the ERK/S6 pathway

International Journal of Molecular Sciences

Volumn 17, Issue 4, 2016, Pages

  Ning, Xiaomin ^a   He, Jingjing ^a   Shi, Xin’E ^a   Yang, Gongshe ^a  

^a NORTHWEST A F UNIVERSITY   (China)

Author keywords

Adipogenesis; ERK S6 signaling; Quinine; T2R106

Indexed keywords

CCAAT ENHANCER BINDING PROTEIN ALPHA; FATTY ACID BINDING PROTEIN 4; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN S6; QUININE; G PROTEIN COUPLED RECEPTOR; RIBOSOMAL PROTEIN S6, MOUSE; TAS2R108 PROTEIN, MOUSE;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ARTICLE; BITTER TASTE; CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; GENE EXPRESSION; GLUCOSE TRANSPORT; LIPID STORAGE; LIPOLYSIS; METABOLIC REGULATION; MOUSE; NONHUMAN; PLASMID; PROADIPOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TASTE BUD; WESTERN BLOTTING; 3T3-L1 CELL LINE; ANIMAL; CYTOLOGY; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; SIGNAL TRANSDUCTION;

3T3-L1 CELLS; ADIPOCYTES; ADIPOGENESIS; ANIMALS; CELL DIFFERENTIATION; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION; MAP KINASE SIGNALING SYSTEM; MICE; QUININE; RECEPTORS, G-PROTEIN-COUPLED; RIBOSOMAL PROTEIN S6;

EID: 84963718244     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms17040504     Document Type: Article

References (46)

1. Ode, K.L.; Frohnert, B.I.; Nathan, B.M. Identification and treatment of metabolic complications in pediatric obesity. Rev. Endocr. Metab. Disord. 2009, 10, 167-188. [CrossRef] [PubMed]
2. Lloyd-Jones, D.; Adams, R.J.; Brown, T.M.; Carnethon, M.; Dai, S.; de Simone, G.; Ferguson, T.B.; Ford, E.; Furie, K.; Gillespie, C; et al. Heart disease and stroke statistics—2010 update: A report from the american heart association. Circulation 2010, 121, e46-e215. [PubMed]
3. Faust, I.M.; Johnson, P.R.; Stern, J.S.; Hirsch, J. Diet-induced adipocyte number increase in adult rats: A new model of obesity. Am. J. Physiol. 1978, 235, E279-E286. [PubMed]
4. Jo, J.; Gavrilova, O.; Pack, S.; Jou, W.; Mullen, S.; Sumner, A.E.; Cushman, S.W.; Periwal, V. Hypertrophy and/or hyperplasia: Dynamics of adipose tissue growth. PLoS Comput. Biol. 2009, 5, e1000324. [CrossRef] [PubMed]
5. Rosen, E.D.; Spiegelman, B.M. What we talk about when we talk about fat. Cell 2014, 156, 20-44. [CrossRef] [PubMed]
6. Achan, J.; Talisuna, A.O.; Erhart, A.; Yeka, A.; Tibenderana, J.K.; Baliraine, F.N.; Rosenthal, P.J.; D’Alessandro, U. Quinine, an old anti-malarial drug in a modern world: Role in the treatment of malaria. Malar. J. 2011, 10. [CrossRef] [PubMed]
7. Hogan, D.B. Quinine: Not a safe drug for treating nocturnal leg cramps. CMAJ Can. Med. Assoc. J. 2015, 187, 237-238. [CrossRef] [PubMed]
8. Choi, S.E. Racial differences between african americans and asian americans in the effect of 6-n-propylthiouracil taste intensity and food liking on body mass index. J. Acad. Nutr. Diet. 2014, 114, 938-944. [CrossRef] [PubMed]
9. Hardy, S.L.; Brennand, C.P.; Wyse, B.W. Taste thresholds of individuals with diabetes mellitus and of control subjects. J. Am. Diet. Assoc. 1981, 79, 286-289. [PubMed]
10. Hayes, J.E.; Feeney, E.L.; Nolden, A.A.; McGeary, J.E. Quinine bitterness and grapefruit liking associate with allelic variants in TAS2R31. Chem. Senses 2015, 40, 437-443. [CrossRef] [PubMed]
11. Park, D.C.; Yeo, J.H.; Ryu, I.Y.; Kim, S.H.; Jung, J.; Yeo, S.G. Differences in taste detection thresholds between normal-weight and obese young adults. Acta Oto-Laryngol. 2015, 135, 478-483. [CrossRef] [PubMed]
12. Keesey, R.E.; Boyle, P.C. Effects of quinine adulteration upon body weight of LH-lesioned and intact male rats. J. Comp. Physiol. Psychol. 1973, 84, 38-46. [CrossRef] [PubMed]
13. Heybach, J.P.; Boyle, P.C. Dietary quinine reduces body weight and food intake independent of aversive taste. Physiol. Behav. 1982, 29, 1171-1173. [CrossRef]
14. King, B.M.; Grossman, S.P. Effects of chronic quinine-adulteration of the water supply on food and fluid intake and body weight in lean and obese hypothalamic hyperphagic rats. Physiol. Behav. 1979, 22, 1203-1206. [CrossRef]
15. Kratz, C.M.; Levitsky, D.A.; Lustick, S. Differential effects of quinine and sucrose octa acetate on food intake in the rat. Physiol. Behav. 1978, 20, 665-667. [CrossRef]
16. Kratz, C.M.; Levitsky, D.A.; Lustick, S.L. Long term effects of quinine on food intake and body weight in the rat. Physiol. Behav. 1978, 21, 321-324. [CrossRef]
17. Peck, J.W. Rats drinking quinine- or caffeine-adulterated water defend lean body weights against caloric and osmotic stress. Physiol. Behav. 1978, 21, 599-607. [CrossRef]
18. Cettour-Rose, P.; Bezencon, C.; Darimont, C.; le Coutre, J.; Damak, S. Quinine controls body weight gain without affecting food intake in male C57Bl6 mice. BMC Physiol. 2013, 13. [CrossRef] [PubMed]
19. Kerr, D.; Bdiri, A. Quinine-associated hypoglycaemia causing diabetes. Diabet. Med. J. Br. Diabet. Assoc. 2008, 25, 241-242. [CrossRef] [PubMed]
20. Simon, B.R.; Parlee, S.D.; Learman, B.S.; Mori, H.; Scheller, E.L.; Cawthorn, W.P.; Ning, X.; Gallagher, K.; Tyrberg, B.; Assadi-Porter, F.M; et al. Artificial sweeteners stimulate adipogenesis and suppress lipolysis independently of sweet taste receptors. J. Biol. Chem. 2013, 288, 32475-32489. [CrossRef] [PubMed]
21. Avau, B.; Bauters, D.; Steensels, S.; Vancleef, L.; Laermans, J.; Lesuisse, J.; Buyse, J.; Lijnen, H.R.; Tack, J.; Depoortere, I. The gustatory signaling pathway and bitter taste receptors affect the development of obesity and adipocyte metabolism in mice. PLoS ONE 2015, 10, e0145538. [CrossRef] [PubMed]
22. Wiener, A.; Shudler, M.; Levit, A.; Niv, M.Y. Bitter DB: A database of bitter compounds. Nucleic Acids Res. 2012, 40, D413-D419. [CrossRef] [PubMed]
23. Kim, H.Y.; Lee, M.Y.; Park, H.M.; Park, Y.K.; Shon, J.C.; Liu, K.H.; Lee, C.H. Urine and serum metabolite profiling of rats fed a high-fat diet and the anti-obesity effects of caffeine consumption. Molecules 2015, 20, 3107-3128. [CrossRef] [PubMed]
24. Shafaie, Y.; Hoffman, D.J.; Tepper, B.J. Consumption of a high-fat soup preload leads to differences in short-term energy and fat intake between prop non-taster and super-taster women. Appetite 2015, 89, 196-202. [CrossRef] [PubMed]
25. Malafaia, A.B.; Nassif, P.A.; Ribas, C.A.; Ariede, B.L.; Sue, K.N.; Cruz, M.A. Obesity induction with high fat sucrose in rats. ABCD Arq. Bras. Cir. Dig. 2013, 26 (Suppl. 1), 17-21. [CrossRef] [PubMed]
26. Yang, Z.H.; Miyahara, H.; Takeo, J.; Katayama, M. Diet high in fat and sucrose induces rapid onset of obesity-related metabolic syndrome partly through rapid response of genes involved in lipogenesis, insulin signalling and inflammation in mice. Diabetol. Metab. Syndr. 2012, 4. [CrossRef] [PubMed]
27. Ohara, T.; Muroyama, K.; Yamamoto, Y.; Murosaki, S. A combination of glucosyl hesperidin and caffeine exhibits an anti-obesity effect by inhibition of hepatic lipogenesis in mice. Phytother. Res. PTR 2015, 29, 310-316. [CrossRef] [PubMed]
28. Chandrashekar, J.; Hoon, M.A.; Ryba, N.J.; Zuker, C.S. The receptors and cells for mammalian taste. Nature 2006, 444, 288-294. [CrossRef] [PubMed]
29. Behrens, M.; Meyerhof, W. Mammalian bitter taste perception. Results Probl. Cell Differ. 2009, 47, 203-220. [PubMed]
30. Bachmanov, A.A.; Beauchamp, G.K. Taste receptor genes. Annu. Rev. Nutr. 2007, 27, 389-414. [CrossRef] [PubMed]
31. Adler, E.; Hoon, M.A.; Mueller, K.L.; Chandrashekar, J.; Ryba, N.J.; Zuker, C.S. A novel family of mammalian taste receptors. Cell 2000, 100, 693-702. [CrossRef]
32. Chandrashekar, J.; Mueller, K.L.; Hoon, M.A.; Adler, E.; Feng, L.; Guo, W.; Zuker, C.S.; Ryba, N.J. T2Rs function as bitter taste receptors. Cell 2000, 100, 703-711. [CrossRef]
33. Matsunami, H.; Montmayeur, J.P.; Buck, L.B. A family of candidate taste receptors in human and mouse. Nature 2000, 404, 601-604. [PubMed]
34. Wu, S.V.; Chen, M.C.; Rozengurt, E. Genomic organization, expression, and function of bitter taste receptors (T2R) in mouse and rat. Physiol. Genom. 2005, 22, 139-149. [CrossRef] [PubMed]
35. Hoon, M.A.; Northup, J.K.; Margolskee, R.F.; Ryba, N.J. Functional expression of the taste specific G-protein, -gustducin. Biochem. J. 1995, 309 Pt 2, 629-636. [CrossRef] [PubMed]
36. McLaughlin, S.K.; McKinnon, P.J.; Margolskee, R.F. Gustducin is a taste-cell-specific G protein closely related to the transducins. Nature 1992, 357, 563-569. [CrossRef] [PubMed]
37. Wong, G.T.; Gannon, K.S.; Margolskee, R.F. Transduction of bitter and sweet taste by gustducin. Nature 1996, 381, 796-800. [CrossRef] [PubMed]
38. Pydi, S.P.; Jaggupilli, A.; Nelson, K.M.; Abrams, S.R.; Bhullar, R.P.; Loewen, M.C.; Chelikani, P. Abscisic acid acts as a blocker of the bitter taste G protein-coupled receptor T2R4. Biochemistry 2015, 54, 2622-2631. [CrossRef] [PubMed]
39. Deshpande, D.A.; Wang, W.C.; McIlmoyle, E.L.; Robinett, K.S.; Schillinger, R.M.; An, S.S.; Sham, J.S.; Liggett, S.B. Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. Nat. Med. 2010, 16, 1299-1304. [CrossRef] [PubMed]
40. Jeon, T.I.; Zhu, B.; Larson, J.L.; Osborne, T.F. SREBP-2 regulates gut peptide secretion through intestinal bitter taste receptor signaling in mice. J. Clin. Investig. 2008, 118, 3693-3700. [CrossRef] [PubMed]
41. Lee, R.J.; Xiong, G.; Kofonow, J.M.; Chen, B.; Lysenko, A.; Jiang, P.; Abraham, V.; Doghramji, L.; Adappa, N.D.; Palmer, J.N, et al. T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. J. Clin. Investig. 2012, 122, 4145-4159. [CrossRef] [PubMed]
42. Masuho, I.; Tateyama, M.; Saitoh, O. Characterization of bitter taste responses of intestinal STC-1 cells. Chem. Senses 2005, 30, 281-290. [CrossRef] [PubMed]
43. Prusty, D.; Park, B.H.; Davis, K.E.; Farmer, S.R. Activation of MEK/ERK signaling promotes adipogenesis by enhancing peroxisome proliferator-activated receptor (PPAR) and C/EBP
44. Tang, Q.Q.; Gronborg, M.; Huang, H.; Kim, J.W.; Otto, T.C.; Pandey, A.; Lane, M.D. Sequential phosphorylation of CCAAT enhancer-binding protein by MAPK and glycogen synthase kinase 3 is required for adipogenesis. Proc. Natl. Acad. Sci. USA 2005, 102, 9766-9771. [CrossRef] [PubMed]
45. Lund, T.C.; Kobs, A.J.; Kramer, A.; Nyquist, M.; Kuroki, M.T.; Osborn, J.; Lidke, D.S.; Low-Nam, S.T.; Blazar, B.R.; Tolar, J. Bone marrow stromal and vascular smooth muscle cells have chemosensory capacity via bitter taste receptor expression. PLoS ONE 2013, 8, e58945. [CrossRef] [PubMed]
46. Du, B.; Cawthorn, W. P.; Su, A.; Doucette, C.R.; Yao, Y.; Hemati, N.; Kampert, S.; McCoin, C.; Broome, D.T.; Rosen, C.J, et al. The transcription factor paired-related homeobox 1 (Prrx1) inhibits adipogenesis by activating transforming growth factor- (TGF) signaling. J. Biol. Chem. 2013, 288, 3036-3047. [CrossRef] [PubMed]