Daf-2, an insulin receptor-like gene that regulates longevity and diapause in Caenorhabditis elegans

Science

Volumn 277, Issue 5328, 1997, Pages 942-946

  Kimura, Koutarou D ^a   Tissenbaum, Heidi A ^a   Liu, Yanxia ^a   Ruvkun, Gary ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN RECEPTOR;

ARTICLE; CAENORHABDITIS ELEGANS; LIFESPAN; LONGEVITY; METABOLIC REGULATION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR GENE; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADIPOSE TISSUE; AMINO ACID SEQUENCE; ANIMALS; CAENORHABDITIS ELEGANS; CAENORHABDITIS ELEGANS PROTEINS; CHROMOSOME MAPPING; CONSERVED SEQUENCE; ENERGY INTAKE; GENES, HELMINTH; GLUCOSE; HUMANS; INSULIN; LARVA; LONGEVITY; MOLECULAR SEQUENCE DATA; MUTATION; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION;

ANIMALIA; CAENORHABDITIS ELEGANS; MAMMALIA;

EID: 0030813398     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.277.5328.942     Document Type: Article

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48. We thank A. Coulson, S. Chissoe, B. Waterston, T. Barnes, E. Zachgo, E. Malone, T. Inoue, J. Thomas, E. Lambie, J. Avruch, J. Kaplan, the Massachusetts General Hospital sequencing facility, the C. elegans Genetics Center, and the Ruvkun and Kaplan labs for assistance. K.D.K. is supported by the Japanese Society for the Promotion of Science. This work was supported by NIH grant RO1AG14161.