메뉴 건너뛰기




Volumn 389, Issue 6653, 1997, Pages 816-824

The capsaicin receptor: A heat-activated ion channel in the pain pathway

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM ION; CAPSAICIN; CATION CHANNEL; ION CHANNEL; VANILLOID RECEPTOR;

EID: 0030777012     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/39807     Document Type: Article
Times cited : (7609)

References (49)
  • 1
    • 0003502036 scopus 로고
    • McGraw-Hill, New York
    • Fields, H. L. Pain (McGraw-Hill, New York, 1987).
    • (1987) Pain
    • Fields, H.L.1
  • 4
    • 0030443812 scopus 로고    scopus 로고
    • Vanilloid receptors: New insights enhance potential as a therapeutic target
    • Szallasi, A. & Blumberg, P. M. Vanilloid receptors: new insights enhance potential as a therapeutic target. Pain 68, 195-208 (1996).
    • (1996) Pain , vol.68 , pp. 195-208
    • Szallasi, A.1    Blumberg, P.M.2
  • 5
    • 0017720392 scopus 로고
    • Pharmacologically induced selective degeneration of chemosensitive primary sensory neurons
    • Jancso, G., Kiraly, E. & Jancso-Gabor, A. Pharmacologically induced selective degeneration of chemosensitive primary sensory neurons. Nature 270, 741-743 (1977).
    • (1977) Nature , vol.270 , pp. 741-743
    • Jancso, G.1    Kiraly, E.2    Jancso-Gabor, A.3
  • 7
    • 0025328825 scopus 로고
    • Sensory neuron-specific actions of capsaicin: Mechanisms and applications
    • Bevan, S. & Szolcsanyi, J. Sensory neuron-specific actions of capsaicin: mechanisms and applications. Trends Pharmacol. Sci. 11, 330-333 (1990).
    • (1990) Trends Pharmacol. Sci. , vol.11 , pp. 330-333
    • Bevan, S.1    Szolcsanyi, J.2
  • 8
    • 9244243039 scopus 로고    scopus 로고
    • Capsaicin activates a nonselective cation channel in cultured neonatal rat dorsal root ganglion neurons
    • Oh, U., Hwang, S. W. & Kim, D. Capsaicin activates a nonselective cation channel in cultured neonatal rat dorsal root ganglion neurons, J. Neurosci. 16, 1659-1667 (1996).
    • (1996) J. Neurosci. , vol.16 , pp. 1659-1667
    • Oh, U.1    Hwang, S.W.2    Kim, D.3
  • 9
    • 0023715884 scopus 로고
    • Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture
    • Wood, J. N. et al. Capsaicin-induced ion fluxes in dorsal root ganglion cells in culture. J. Neurosci. 8, 3208-3220 (1988).
    • (1988) J. Neurosci. , vol.8 , pp. 3208-3220
    • Wood, J.N.1
  • 10
    • 0028885830 scopus 로고
    • Capsaicin and its analogs induce ion channels in planar lipid bilayers
    • Feigin, A. M., Aaronov, E. V., Bryant, B. P., Teeter, J. H. & Brand, J. G. Capsaicin and its analogs induce ion channels in planar lipid bilayers. Neuroreport 6, 2134-2136 (1995).
    • (1995) Neuroreport , vol.6 , pp. 2134-2136
    • Feigin, A.M.1    Aaronov, E.V.2    Bryant, B.P.3    Teeter, J.H.4    Brand, J.G.5
  • 11
    • 0016786589 scopus 로고
    • Sensor effects of capsaicin congeners I. Relationship between chemical structure and pain-producing potency of pungent agents
    • Szolcsanyi, J. & Jancso-Gabor, A. Sensor effects of capsaicin congeners I. Relationship between chemical structure and pain-producing potency of pungent agents. Drug Res. 25, 1877-1881 (1975).
    • (1975) Drug Res. , vol.25 , pp. 1877-1881
    • Szolcsanyi, J.1    Jancso-Gabor, A.2
  • 12
    • 0017226275 scopus 로고
    • Sensory effects of capsaicin congeners II Importance of chemical structure and pungency in desensitizing activity of capsaicin-like compounds
    • Szolcsanyi, J. & Jancso-Gabor, A. Sensory effects of capsaicin congeners II Importance of chemical structure and pungency in desensitizing activity of capsaicin-like compounds. Drug Res. 26, 33-37 (1976).
    • (1976) Drug Res. , vol.26 , pp. 33-37
    • Szolcsanyi, J.1    Jancso-Gabor, A.2
  • 13
    • 0026767602 scopus 로고
    • Capsazepine: A competitive antagonist of the sensory neuron excitant capsaicin
    • Bevan, S. et al. Capsazepine: a competitive antagonist of the sensory neuron excitant capsaicin. Br. J. Pharmacol 107, 544-552 (1992).
    • (1992) Br. J. Pharmacol , vol.107 , pp. 544-552
    • Bevan, S.1
  • 14
    • 0024501543 scopus 로고
    • Thermoregulatory effects of resiniferatoxin in the mouse: Comparison with capsaicin
    • deVries, D. J. & Blumberg, P. M. Thermoregulatory effects of resiniferatoxin in the mouse: comparison with capsaicin. Life Sci, 44, 711-715 (1989).
    • (1989) Life Sci , vol.44 , pp. 711-715
    • DeVries, D.J.1    Blumberg, P.M.2
  • 15
    • 0024382437 scopus 로고
    • Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper
    • Szallasi, A. & Blumberg, P. M. Resiniferatoxin, a phorbol-related diterpene, acts as an ultrapotent analog of capsaicin, the irritant constituent in red pepper. Neuroscience 30, 515-520 (1989).
    • (1989) Neuroscience , vol.30 , pp. 515-520
    • Szallasi, A.1    Blumberg, P.M.2
  • 16
    • 0028175616 scopus 로고
    • The vanilloid (capsaicin) receptor: Receptor types and species specificity
    • Szallasi, A. The vanilloid (capsaicin) receptor: Receptor types and species specificity. Gen. Pharmacol. 25, 223-243 (1994).
    • (1994) Gen. Pharmacol. , vol.25 , pp. 223-243
    • Szallasi, A.1
  • 17
    • 0025191123 scopus 로고
    • Ruthenium red blocks the capsaicin-induced increase in intracellular calcium and activation of membrane currents in sensory neurones as well as the activation of peripheral nociceptors in vitro
    • Dray, A., Forbes, C. A. & Burgess, G. M. Ruthenium red blocks the capsaicin-induced increase in intracellular calcium and activation of membrane currents in sensory neurones as well as the activation of peripheral nociceptors in vitro. Neurosci, Lett. 110, 52-59 (1990).
    • (1990) Neurosci, Lett. , vol.110 , pp. 52-59
    • Dray, A.1    Forbes, C.A.2    Burgess, G.M.3
  • 18
    • 0024488636 scopus 로고
    • Fluorescent probes of cell signaling
    • Tsien, R. Y. Fluorescent probes of cell signaling. Annu. Rev. Neurosci. 12, 227-253 (1989).
    • (1989) Annu. Rev. Neurosci. , vol.12 , pp. 227-253
    • Tsien, R.Y.1
  • 19
    • 0025296259 scopus 로고
    • Cellular mechanism of action of resiniferatoxin: A potent sensory neuron excitotoxin
    • Winter, J., Dray, A., Wood, J. N., Yeats, J. C. & Bevan, S. Cellular mechanism of action of resiniferatoxin: a potent sensory neuron excitotoxin. Brain Res. 520, 131-140 (1990).
    • (1990) Brain Res. , vol.520 , pp. 131-140
    • Winter, J.1    Dray, A.2    Wood, J.N.3    Yeats, J.C.4    Bevan, S.5
  • 20
    • 0028123430 scopus 로고
    • A rapid capsaicin-activated current in rat trigeminal ganglion neurons
    • Liu, L. & Simon, S. A. A rapid capsaicin-activated current in rat trigeminal ganglion neurons. Proc. Natl Acad. Sci. USA 91, 738-741 (1994).
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 738-741
    • Liu, L.1    Simon, S.A.2
  • 22
    • 0000920261 scopus 로고
    • Determination of capsicum pungency by high pressure liquid chromatography and spectrofluorometric determination
    • Woodbury, J. E. Determination of capsicum pungency by high pressure liquid chromatography and spectrofluorometric determination. J. Assoc. Official Anal. Chem. 63, 556-558 (1980).
    • (1980) J. Assoc. Official Anal. Chem. , vol.63 , pp. 556-558
    • Woodbury, J.E.1
  • 24
    • 0023492484 scopus 로고
    • Permeation and block of N-methyl-D-aspartic acid receptor channels by divalent cations in mouse cultured central neurons
    • Mayer, M. L. & Westbrook, G. L. Permeation and block of N-methyl-D-aspartic acid receptor channels by divalent cations in mouse cultured central neurons. J. Physiol. (Lond.) 394, 501-527 (1987).
    • (1987) J. Physiol. (Lond.) , vol.394 , pp. 501-527
    • Mayer, M.L.1    Westbrook, G.L.2
  • 25
    • 0027518923 scopus 로고
    • Molecular cloning, functional properties, and distribution of rat brain a7: A nicotinic cation channel highly permeable to calcium
    • Seguela, P., Wadiche, J., Dineley-Miller, K., Dani, J. A. & Patrick J. W. Molecular cloning, functional properties, and distribution of rat brain a7: a nicotinic cation channel highly permeable to calcium. J. Neurosci. 13, 596-604 (1993).
    • (1993) J. Neurosci. , vol.13 , pp. 596-604
    • Seguela, P.1    Wadiche, J.2    Dineley-Miller, K.3    Dani, J.A.4    Patrick, J.W.5
  • 26
    • 0026608469 scopus 로고
    • Calcium-dependent and -independent desensitization of capsaicin-evoked responses in voltage-clamped adult rat dorsal root ganglion (DRG) neurones in culture
    • Yeats, J. C., Docherty, R. J. & Bevan, S. Calcium-dependent and -independent desensitization of capsaicin-evoked responses in voltage-clamped adult rat dorsal root ganglion (DRG) neurones in culture. J. Physiol (Lond.) 446, 390P (1992).
    • (1992) J. Physiol (Lond.) , vol.446
    • Yeats, J.C.1    Docherty, R.J.2    Bevan, S.3
  • 27
    • 0025871477 scopus 로고
    • Capsaicin: Cellular targets, mechanisms of action, and selectivity for thin sensory neurons
    • Holzer, P. Capsaicin: Cellular targets, mechanisms of action, and selectivity for thin sensory neurons. Pharmacol Rev. 43, 143-201 (1991).
    • (1991) Pharmacol Rev. , vol.43 , pp. 143-201
    • Holzer, P.1
  • 28
    • 0002174719 scopus 로고
    • Single channels activated by capsaicin in patches of membrane from adult rat sensory neurones in culture
    • Forbes, C. A. & Bevan, S. Single channels activated by capsaicin in patches of membrane from adult rat sensory neurones in culture. Neurosci. Lett, (suppl.) 32, S3 (1988).
    • (1988) Neurosci. Lett, (suppl.) , vol.32
    • Forbes, C.A.1    Bevan, S.2
  • 29
    • 0026344133 scopus 로고
    • Prevention of apoptosis by a Bacculovirus gene during infection of insect cells
    • Crem, R. J., Fechheimer, M. & Miller, L. K. Prevention of apoptosis by a Bacculovirus gene during infection of insect cells. Science 254, 1388-1390 (1991).
    • (1991) Science , vol.254 , pp. 1388-1390
    • Crem, R.J.1    Fechheimer, M.2    Miller, L.K.3
  • 30
    • 0028016077 scopus 로고
    • Glutamate receptors and the induction of excitotoxic neuronal death
    • Choi, D. W. Glutamate receptors and the induction of excitotoxic neuronal death. Prog. Brain Res. 100, 47-51 (1994).
    • (1994) Prog. Brain Res. , vol.100 , pp. 47-51
    • Choi, D.W.1
  • 31
    • 0028157551 scopus 로고
    • A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans
    • Hong, K. & Driscoll, M. A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans. Nature 367, 470-473 (1994).
    • (1994) Nature , vol.367 , pp. 470-473
    • Hong, K.1    Driscoll, M.2
  • 32
    • 0024642547 scopus 로고
    • Molecular characterization of the Drosophila trp locus: A putative integral membrane protein required for phototransduction
    • Montell, C. & Rubin, G. M. Molecular characterization of the Drosophila trp locus: A putative integral membrane protein required for phototransduction. Neuron 2, 1313-1323 (1989).
    • (1989) Neuron , vol.2 , pp. 1313-1323
    • Montell, C.1    Rubin, G.M.2
  • 34
    • 0030175896 scopus 로고    scopus 로고
    • TRP is cracked, but is CRAG TRP?
    • Clapham, D. E. TRP is cracked, but is CRAG TRP? Neuron 16, 1069-1072 (1996).
    • (1996) Neuron , vol.16 , pp. 1069-1072
    • Clapham, D.E.1
  • 35
    • 0029094168 scopus 로고
    • Putative capacitative calcium entry channels: Expression of Drosophila trp and evidence for the existence of venebrate homologs
    • Petersen, C. C. H., Berridge, M, J., Borgese, M. F. & Bennett, D. L. Putative capacitative calcium entry channels: expression of Drosophila trp and evidence for the existence of venebrate homologs. Biochem. J. 311, 41-44 (1995).
    • (1995) Biochem. J. , vol.311 , pp. 41-44
    • Petersen, C.C.H.1    Berridge, M.J.2    Borgese, M.F.3    Bennett, D.L.4
  • 36
    • 0025103909 scopus 로고
    • SK&F 96365, a novel inhibitor of receptor-mediated calcium entry
    • Merritt, J. E. et al. SK&F 96365, a novel inhibitor of receptor-mediated calcium entry. Biochem. J. 271, 515-522 (1990).
    • (1990) Biochem. J. , vol.271 , pp. 515-522
    • Merritt, J.E.1
  • 37
    • 0001662431 scopus 로고
    • Behavioral thermoregulation in response to local cooling of the rat brain
    • Satinoff, E. Behavioral thermoregulation in response to local cooling of the rat brain. Am. J. Physiol. 206, 1389-1394 (1964).
    • (1964) Am. J. Physiol. , vol.206 , pp. 1389-1394
    • Satinoff, E.1
  • 38
    • 0027988505 scopus 로고
    • Protons: Small stimulants of capsaicin-sensitive sensory nerves
    • Bevan, S. & Geppetti, P. Protons: small stimulants of capsaicin-sensitive sensory nerves. Trends Neurosci. 17, 509-512 (1994).
    • (1994) Trends Neurosci. , vol.17 , pp. 509-512
    • Bevan, S.1    Geppetti, P.2
  • 39
    • 0027289209 scopus 로고
    • Effect of protons on the inward current evoked by capsaicin in isolated dorsal root ganglion cells
    • Petersen, M. & LaMotte, R. H. Effect of protons on the inward current evoked by capsaicin in isolated dorsal root ganglion cells. Pain 54, 37-42 (1993).
    • (1993) Pain , vol.54 , pp. 37-42
    • Petersen, M.1    LaMotte, R.H.2
  • 40
    • 0030582980 scopus 로고    scopus 로고
    • Low pH facilitates capsaicin responses in isolated sensory neurons of the rat
    • Kress, M., Fetzer, S., Reeh, P. W. & Vyklicky, L. Low pH facilitates capsaicin responses in isolated sensory neurons of the rat. Neurosci. Lett. 211, 5-8 (1996).
    • (1996) Neurosci. Lett. , vol.211 , pp. 5-8
    • Kress, M.1    Fetzer, S.2    Reeh, P.W.3    Vyklicky, L.4
  • 41
    • 0017466754 scopus 로고
    • Opiate receptors and internal opiates
    • Snyder, S. H. Opiate receptors and internal opiates. Sci. Am, 236, 44-56 (1977).
    • (1977) Sci. Am , vol.236 , pp. 44-56
    • Snyder, S.H.1
  • 42
    • 0030446311 scopus 로고    scopus 로고
    • A. novel heat-activated current in nociceptive neurons and its sensitization by bradykinin
    • Cesare, P. & McNaughton, P. A. novel heat-activated current in nociceptive neurons and its sensitization by bradykinin. Proc. Natl Acad. Sci. USA 93, 15435-15439 (1996).
    • (1996) Proc. Natl Acad. Sci. USA , vol.93 , pp. 15435-15439
    • Cesare, P.1    McNaughton, P.2
  • 43
    • 0030978813 scopus 로고    scopus 로고
    • Heat transduction in rat sensory neurons by calcium-dependent activation of a cation channel
    • Reichling, D. B. & Levine, J. D. Heat transduction in rat sensory neurons by calcium-dependent activation of a cation channel. Proc. Natl Acad. Sci. USA 94, 7006-7011 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , pp. 7006-7011
    • Reichling, D.B.1    Levine, J.D.2
  • 44
    • 0025166553 scopus 로고
    • Activation of primary afferent neurons by thermal stimulation: Influence of Ruthenium Red
    • Amann, R., Donnerer, J. & Lembeck, F. Activation of primary afferent neurons by thermal stimulation: influence of Ruthenium Red, Naunyn Schmiedeberg's Arch. Pharmacol. 341, 108-113 (1990).
    • (1990) Naunyn Schmiedeberg's Arch. Pharmacol. , vol.341 , pp. 108-113
    • Amann, R.1    Donnerer, J.2    Lembeck, F.3
  • 45
    • 0343924358 scopus 로고    scopus 로고
    • Coexpression of heat-evoked and capsaicin-evoked inward currents in acutely dissociated rat dorsal root ganglion neurons
    • Kirschstein, T., Busselberg, D. & Treede, R. D. Coexpression of heat-evoked and capsaicin-evoked inward currents in acutely dissociated rat dorsal root ganglion neurons. Neurosci. Lett. 231, 33-36 (1997).
    • (1997) Neurosci. Lett. , vol.231 , pp. 33-36
    • Kirschstein, T.1    Busselberg, D.2    Treede, R.D.3
  • 46
    • 0028025001 scopus 로고
    • New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor
    • Brake, A., Wagenbach, M. J. & Julius, D. New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor. Nature 371, 519-523 (1994).
    • (1994) Nature , vol.371 , pp. 519-523
    • Brake, A.1    Wagenbach, M.J.2    Julius, D.3
  • 47
    • 0000448982 scopus 로고
    • Prediction of protein antigenic determinants from amino acid sequences
    • Hopp, T. P. & Woods, K. R. Prediction of protein antigenic determinants from amino acid sequences. Proc. Natl Acad. Sci. USA 78, 3824-3828 (1981).
    • (1981) Proc. Natl Acad. Sci. USA , vol.78 , pp. 3824-3828
    • Hopp, T.P.1    Woods, K.R.2
  • 48
    • 0028030797 scopus 로고
    • A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP
    • Valera, S. et al. A new class of ligand-gated ion channel defined by P2X receptor for extracellular ATP. Nature 371, 516-519 (1994).
    • (1994) Nature , vol.371 , pp. 516-519
    • Valera, S.1
  • 49
    • 0020949591 scopus 로고
    • Laboratory methods: A method for isolation of intact, translationally active ribonudeic acid
    • Cathala, G. et al. Laboratory methods: A method for isolation of intact, translationally active ribonudeic acid. DNA 2, 329-335 (1983).
    • (1983) DNA , vol.2 , pp. 329-335
    • Cathala, G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.