Expression, Regulation and Putative Nutrient-Sensing Function of Taste GPCRs in the Heart

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Foster, Simon R ^a   Porrello, Enzo R ^a   Purdue, Brooke ^a   Chan, Hsiu Wen ^a   Voigt, Anja ^b   Frenzel, Sabine ^b   Hannan, Ross D ^c   Moritz, Karen M ^a   Simmons, David G ^a   Molenaar, Peter ^d   Roura, Eugeni ^a   Boehm, Ulrich ^e,f   Meyerhof, Wolfgang ^b   Thomas, Walter G ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^c UNIVERSITY OF MELBOURNE   (Australia)

^d QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^e UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^f SAARLAND UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTOR; TASTE RECEPTORS, TYPE 2;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FIBROBLAST; GENE; GENE EXPRESSION; HEART; HEART MUSCLE; HEART MUSCLE CELL; HUMAN; HUMAN TISSUE; IN VIVO STUDY; MOUSE; NEWBORN; NONHUMAN; NUTRIENT; PERINATAL PERIOD; PROTEIN FUNCTION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TAS1 GENE; TAS1R1 GENE; TAS1R3 GENE; TAS2 GENE; TAS2R108 GENE; TAS2R120 GENE; TAS2R121 GENE; TAS2R126 GENE; TAS2R135 GENE; TAS2R137 GENE; TAS2R143 GENE; TASTE; UPREGULATION; ANIMAL; CHROMOSOME MAP; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; STARVATION;

ANIMALS; FIBROBLASTS; GENE EXPRESSION REGULATION; HUMANS; MICE; MYOCARDIUM; MYOCYTES, CARDIAC; PHYSICAL CHROMOSOME MAPPING; RATS; RECEPTORS, G-PROTEIN-COUPLED; STARVATION; TASTE;

EID: 84877790035     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0064579     Document Type: Article

References (46)

1. Lagerstrom MC, Schioth HB, (2008) Structural diversity of G protein-coupled receptors and significance for drug discovery. Nat Rev Drug Discov 7: 339-357.
2. Overington JP, Al-Lazikani B, Hopkins AL, (2006) How many drug targets are there? Nat Rev Drug Discov 5: 993-996.
3. Insel PA, Snead A, Murray F, Zhang L, Yokouchi H, et al. (2012) GPCR expression in tissues and cells: Are the optimal receptors being used as drug targets? Br J Pharmacol 165: 1613-1616.
4. Moore-Morris T, Varrault A, Mangoni ME, Le Digarcher A, Negre V, et al. (2009) Identification of Potential Pharmacological Targets by Analysis of the Comprehensive G Protein-Coupled Receptor Repertoire in the Four Cardiac Chambers. Mol Pharmacol 75: 1108-1116.
5. Ren X, Zhou L, Terwilliger R, Newton SS, de Araujo IE, (2009) Sweet taste signaling functions as a hypothalamic glucose sensor. Front Integr Neurosci 3: 12.
6. Jang HJ, Kokrashvili Z, Theodorakis MJ, Carlson OD, Kim BJ, et al. (2007) Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. Proc Natl Acad Sci U S A 104: 15069-15074.
7. Mace OJ, Lister N, Morgan E, Shepherd E, Affleck J, et al. (2009) An energy supply network of nutrient absorption coordinated by calcium and T1R taste receptors in rat small intestine. J Physiol 587: 195-210.
8. Margolskee RF, Dyer J, Kokrashvili Z, Salmon KSH, Ilegems E, et al. (2007) T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1. Proc Natl Acad Sci U S A 104: 15075-15080.
9. Wauson EM, Zaganjor E, Lee AY, Guerra ML, Ghosh AB, et al. (2012) The G protein-coupled taste receptor T1R1/T1R3 regulates mTORC1 and autophagy. Mol Cell 47: 851-862.
10. Meyerhof W, Batram C, Kuhn C, Brockhoff A, Chudoba E, et al. (2010) The Molecular Receptive Ranges of Human TAS2R Bitter Taste Receptors. Chem Senses 35: 157-170.
11. Finger TE, Kinnamon SC, (2011) Taste isn't just for taste buds anymore. F1000 Biol Rep 3: 20.
12. Deshpande DA, Wang WC, McIlmoyle EL, Robinett KS, Schillinger RM, et al. (2010) Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction. Nat Med 16: 1299-1304.
13. Finger TE, Böttger B, Hansen A, Anderson KT, Alimohammadi H, et al. (2003) Solitary chemoreceptor cells in the nasal cavity serve as sentinels of respiration. Proc Natl Acad Sci U S A 100: 8981-8986.
14. Tizzano M, Cristofoletti M, Sbarbati A, Finger T, (2011) Expression of taste receptors in Solitary Chemosensory Cells of rodent airways. BMC Pulm Med 11: 3.
15. Janssen S, Laermans J, Verhulst PJ, Thijs T, Tack J, et al. (2011) Bitter taste receptors and {alpha}-gustducin regulate the secretion of ghrelin with functional effects on food intake and gastric emptying. Proc Natl Acad Sci U S A 108: 2094-2099.
16. Jeon TI, Seo YK, Osborne TF, (2011) Gut Bitter Taste Receptor Signaling Induces ABCB1 through a Mechanism Involving CCK. Biochem J 438: 33-37.
17. Luche H, Weber O, Nageswara Rao T, Blum C, Fehling HJ, (2007) Faithful activation of an extra-bright red fluorescent protein in "knock-in" Cre-reporter mice ideally suited for lineage tracing studies. Eur J Immunol 37: 43-53.
18. Wen S, Götze IN, Mai O, Schauer C, Leinders-Zufall T, et al. (2011) Genetic Identification of GnRH Receptor Neurons: A New Model for Studying Neural Circuits Underlying Reproductive Physiology in the Mouse Brain. Endocrinology 152: 1515-1526.
19. Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y, (2004) In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 15: 1101-1111.
20. Kaumann A, Bartel S, Molenaar P, Sanders L, Burrell K, et al. (1999) Activation of β2-Adrenergic Receptors Hastens Relaxation and Mediates Phosphorylation of Phospholamban, Troponin I, and C-Protein in Ventricular Myocardium From Patients With Terminal Heart Failure. Circulation 99: 65-72.
21. Thomas WG, Brandenburger Y, Autelitano DJ, Pham T, Qian HW, et al. (2002) Adenoviral-directed expression of the type 1A angiotensin receptor promotes cardiomyocyte hypertrophy via transactivation of the epidermal growth factor receptor. Circ Res 90: 135-142.
22. Cui WW, Taub DD, Gardner K, (2007) qPrimerDepot: a primer database for quantitative real time PCR. Nucleic Acids Res 35: D805-D809.
23. Livak KJ, Schmittgen TD, (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(T)(-Delta Delta C) method. Methods 25: 402-408.
24. Simmons D, Rawn S, Davies A, Hughes M, Cross J, (2008) Spatial and temporal expression of the 23 murine Prolactin/Placental Lactogen-related genes is not associated with their position in the locus. BMC Genomics 9: 352.
25. Shi P, Zhang J, Yang H, Zhang Y, (2003) Adaptive diversification of bitter taste receptor genes in Mammalian evolution. Mol Biol Evol 20: 805-814.
26. Regard JB, Sato IT, Coughlin SR, (2008) Anatomical profiling of G protein-coupled receptor expression. Cell 135: 561-571.
27. Tang CM, Insel PA, (2004) GPCR expression in the heart - "New" receptors in myocytes and fibroblasts. Trends Cardiovasc Med 14: 94-99.
28. Snead AN, Insel PA (2012) Defining the cellular repertoire of GPCRs identifies a profibrotic role for the most highly expressed receptor, protease-activated receptor 1, in cardiac fibroblasts. FASEB J.
29. Behrens M, Meyerhof W, (2011) Gustatory and extragustatory functions of mammalian taste receptors. Physiol Behav 105: 4-13.
30. Wellendorph P, Johansen LD, Brauner-Osborne H, (2009) Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients. Mol Pharmacol 76: 453-465.
31. Toyono T, Seta Y, Kataoka S, Toyoshima K, (2007) CCAAT/Enhancer-binding protein beta regulates expression of human T1R3 taste receptor gene in the bile duct carcinoma cell line, HuCCT1. Biochimica Et Biophysica Acta-Gene Structure and Expression 1769: 641-648.
32. Young RL, Sutherland K, Pezos N, Brierley SM, Horowitz M, et al. (2009) Expression of taste molecules in the upper gastrointestinal tract in humans with and without type 2 diabetes. Gut 58: 337-346.
33. Dotson CD, Zhang L, Xu H, Shin YK, Vigues S, et al. (2008) Bitter Taste Receptors Influence Glucose Homeostasis. PLoS One 3: e3974.
34. Lee RJ, Xiong G, Kofonow JM, Chen B, Lysenko A, et al. (2012) T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. J Clin Invest.
35. Akao H, Polisecki E, Kajinami K, Trompet S, Robertson M, et al. (2012) KIF6, LPA, TAS2R50, and VAMP8 genetic variation, low density lipoprotein cholesterol lowering response to pravastatin, and heart disease risk reduction in the elderly. Atherosclerosis 220: 456-462.
36. Shiffman D, O'Meara ES, Bare LA, Rowland CM, Louie JZ, et al. (2008) Association of Gene Variants With Incident Myocardial Infarction in the Cardiovascular Health Study. Arteriosclerosis, Thrombosis, and Vascular Biology 28: 173-179.
37. Duffy VB, (2004) Associations between oral sensation, dietary behaviors and risk of cardiovascular disease (CVD). Appetite 43: 5-9.
38. Smith NJ (2012) Low affinity GPCRs for metabolic intermediates: challenges for pharmacologists. Frontiers in Endocrinology 3.
39. Tonack S, Tang C, Offermanns S (2012) Endogenous metabolites as ligands for G-coupled receptors modulating risk factors for metabolic and cardiovascular disease. Am J Physiol Heart Circ Physiol.
40. Deng H, Hu H, Fang Y (2012) Multiple tyrosine metabolites are GPR35 agonists. Sci Rep 2.
41. Patwardhan AM, Akopian AN, Ruparel NB, Diogenes A, Weintraub ST, et al. (2010) Heat generates oxidized linoleic acid metabolites that activate TRPV1 and produce pain in rodents. J Clin Invest 120: 1617-1626.
42. Sotnikova TD, Caron MG, Gainetdinov RR, (2009) Trace Amine-Associated Receptors as Emerging Therapeutic Targets. Molecular Pharmacology 76: 229-235.
43. Waku T, Shiraki T, Oyama T, Maebara K, Nakamori R, et al. (2010) The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites. EMBO J 29: 3395-3407.
44. Wootten D, Savage EE, Valant C, May LT, Sloop KW, et al. (2012) Allosteric modulation of endogenous metabolites as an avenue for drug discovery. Mol Pharmacol 82: 281-290.
45. Slack JP, Brockhoff A, Batram C, Menzel S, Sonnabend C, et al. (2010) Modulation of bitter taste perception by a small molecule hTAS2R antagonist. Curr Biol 20: 1104-1109.
46. Clark AA, Liggett SB, Munger SD, (2012) Extraoral bitter taste receptors as mediators of off-target drug effects. FASEB J 26: 4827-4831.