TRPV channels and vascular function

Acta Physiologica

Volumn 203, Issue 1, 2011, Pages 99-116

  Baylie, R L ^a   Brayden, J E ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

Endothelium; Neurovascular; Smooth muscle; TRPV channels

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE; CYTOCHROME P450; ENDOCANNABINOID; EPOXYICOSATRIENOIC ACID; NITRIC OXIDE; PHOSPHOLIPASE A2; POTASSIUM CHANNEL; PROSTACYCLIN; SUBSTANCE P; VANILLOID RECEPTOR; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 2; VANILLOID RECEPTOR 3; VANILLOID RECEPTOR 4; VANILLOID RECEPTOR 5; VANILLOID RECEPTOR 6;

AORTA; ASTROCYTE; BASILAR ARTERY; BLOOD VESSEL INNERVATION; BRAIN ARTERY; BRAIN CAPILLARY; CALCIUM CELL LEVEL; CARDIOVASCULAR FUNCTION; CELL CULTURE; CELL FUNCTION; CORONARY ARTERY; ENDOTHELIUM CELL; ENZYME ACTIVITY; HUMAN; HYPERPOLARIZATION; MESENTERIC ARTERY; MIDDLE CEREBRAL ARTERY; NONHUMAN; OSMORECEPTION; OSMOTIC STRESS; PRESSORECEPTOR REFLEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; PROTEIN STRUCTURE; PULMONARY ARTERY; REVIEW; SENSORY NERVE; SHEAR STRESS; SKELETAL MUSCLE; SMOOTH MUSCLE FIBER; SUPRAOPTIC NUCLEUS; VASCULARIZATION; VASODILATATION; VASOMOTOR REFLEX;

ANIMALS; CARDIOVASCULAR SYSTEM; HEMODYNAMICS; HUMANS; TRPV CATION CHANNELS;

EID: 80051658054     PISSN: 17481708     EISSN: 17481716     Source Type: Journal    
DOI: 10.1111/j.1748-1716.2010.02217.x     Document Type: Review

References (154)

1. Adamian, L. & Liang, J. 2006. Prediction of transmembrane helix orientation in polytopic membrane proteins. BMC Structural Biology, 6, 13.
2. Al-Ansary, D., Bogeski, I., Disteldorf, B.M.J., Becherer, U. & Niemeyer, B.A. 2010. ATP modulates Ca2+ uptake by TRPV6 and is counteracted by isoform-specific phosphorylation. FASEB J, 24, 425-435.
3. Alessandri-Haber, N., Joseph, E., Dina, O.A., Liedtke, W. & Levine, J.D. 2005. TRPV4 mediates pain-related behavior induced by mild hypertonic stimuli in the presence of inflammatory mediator. Pain, 118, 70-79.
4. Appendino, G., Minassi, A., Pagani, A. & Ech-Chahad, A. 2008. The role of natural products in the ligand deorphanization of TRP channels. Curr Pharm Des, 14, 2-17.
5. Arniges, M., Fernandez-Fernandez, J.M., Albrecht, N., Schaefer, M. & Valverde, M.A. 2006. Human TRPV4 channel splice variants revealed a key role of ankyrin domains in multimerization and trafficking. J Biol Chem, 281, 1580-1586.
6. Auer-Grumbach, M., Olschewski, A., Papic, L., Kremer, H., McEntagart, M.E., Uhrig, S., Fischer, C., Frohlich, E., Balint, Z., Tang, B. et al. 2010. Alterations in the ankyrin domain of TRPV4 cause congenital distal SMA, scapuloperoneal SMA and HMSN2C. Nat Genet 42, 160-164.
7. Bayliss, W. 1902. On the local reactions of the arterial wall to changes of internal pressure. J Physiol 28, 220-231.
8. Becker, D., Muller, M., Leuner, K. & Jendrach, M. 2008. The C-terminal domain of TRPV4 is essential for plasma membrane localization. Mol Membr Biol 25, 139-151.
9. Benfenati, V., Amiry-Moghaddam, M., Caprini, M., Mylonakou, M.N., Rapisarda, C., Ottersen, O.P. & Ferroni, S. 2007. Expression and functional characterization of transient receptor potential vanilloid-related channel 4 (TRPV4) in rat cortical astrocytes. Neuroscience 148, 876-892.
10. Birder, L.A., Nakamura, Y., Kiss, S., Nealen, M.L., Barrick, S., Kanai, A.J., Wang, E., Ruiz, G., de Groat, W.C., Apodaca, G., Watkins, S. & Caterina, M.J. 2002. Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. Nat Neurosci 5, 856-860.
11. Bratz, I.N., Dick, G.M., Tune, J.D., Edwards, J.M., Neeb, Z.P., Dincer, U.D. & Sturek, M. 2008. Impaired capsaicin-induced relaxation of coronary arteries in a porcine model of the metabolic syndrome. Am J Physiol Heart Circ Physiol 294, H2489-H2496.
12. Brauchi, S., Orta, G., Salazar, M., Rosenmann, E. & Latorre, R. 2006. A Hot-Sensing Cold Receptor: C-Terminal domain determines thermosensation in transient receptor potential channels. J Neurosci, 26, 4835-4840.
13. Campbell, W.B., Gebremedhin, D., Pratt, P.F. & Harder, D.R. 1996. Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ Res 78, 415-423.
14. Caterina, M.J., Schumacher, M.A., Tominaga, M., Rosen, T.A., Levine, J.D. & Julius, D. 1997. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 389, 816-824.
15. Caterina, M.J., Rosen, T.A., Tominaga, M., Brake, A.J. & Julius, D. 1999. A capsaicin-receptor homologue with a high threshold for noxious heat. Nature 398, 436-441.
16. Caterina, M.J., Leffler, A., Malmberg, A.B., Martin, W.J., Trafton, J., Petersen-Zeitz, K.R., Koltzenburg, M., Basbaum, A.I. & Julius, D. 2000. Impaired nociception and pain sensation in mice lacking the capsaicin receptor. Science 288, 306-313.
17. Chang, Q., Gyftogianni, E., van de Graaf, S.F.J., Hoefs, S., Weidema, F.A., Bindels, R.J.M. & Hoenderop, J.G.J. 2004. Molecular determinants in TRPV5 channel assembly. J Biol Chem, 279, 54304-54311.
18. Cheng, W., Yang, F., Takanishi, C.L. & Zheng, J. 2007. Thermosensitive TRPV channel subunits coassemble into heteromeric channels with intermediate conductance and gating properties. J Gen Physiol, 129, 191-207.
19. Christoph, T., Bahrenberg, G., De Vry, J., Englberger, W., Erdmann, V.A., Frech, M., Kögel, B., Röhl, T., Schiene, K., Schröder, W., Seibler, J. & Kurreck, J. 2008. Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice. Mol Cell Neurosci 37, 579-589.
20. Chung, M.-K., Lee, H. & Caterina, M.J. 2003. Warm temperatures activate TRPV4 in mouse 308 keratinocytes. J Biol Chem 278, 32037-32046.
21. Chung, M.-K., Lee, H., Mizuno, A., Suzuki, M. & Caterina, M.J. 2004. TRPV3 and TRPV4 mediate warmth-evoked currents in primary mouse keratinocytes. J Biol Chem 279, 21569-21575.
22. Chung, M.-K., Guler, A.D. & Caterina, M.J. 2008. TRPV1 shows dynamic ionic selectivity during agonist stimulation. Nat Neurosci, 11, 555-564.
23. Ciura, S. & Bourque, C.W. 2006. Transient receptor potential vanilloid 1 is required for intrinsic osmoreception in organum vasculosum lamina terminalis neurons and for normal thirst responses to systemic hyperosmolality. J Neurosci 26, 9069-9075.
24. Clapham, D.E. 2003. TRP channels as cellular sensors. Nature, 426, 517-524.
25. Clapham, D., Runnels, L. & Strubing, C. 2001. The TRP ion channel family. Nat Rev Neurosci, 2, 387-396.
26. Davis, J.B., Gray, J., Gunthorpe, M.J., Hatcher, J.P., Davey, P.T., Overend, P., Harries, M.H., Latcham, J., Clapham, C., Atkinson, K. et al. 2000. Vanilloid receptor-1 is essential for inflammatory thermal hyperalgesia. Nature 405, 183-187.
27. D'hoedt, D., Owsianik, G., Prenen, J., Cuajungco, M.P., Grimm, C., Heller, S., Voets, T. & Nilius, B. 2008. Stimulus-specific modulation of the cation channel TRPV4 by PACSIN 3. J Biol Chem 283, 6272-6280.
28. Di, A. & Malik, A.B. 2010. TRP channels and the control of vascular function. Curr Op Pharmacol, 10, 127-132.
29. Dodier, Y., Dionne, F., Raybaud, A., Sauve, R. & Parent, L. 2007. Topology of the selectivity filter of a TRPV channel: rapid accessibility of contiguous residues from the external medium. Am J Physiol Cell Physiol, 293, C1962-1970.
30. Earley, S. 2010. Vanilloid and melastatin transient receptor potential channels in vascular smooth muscle. Microcirculation, 17, 237-249.
31. 2+ signaling complex with ryanodine receptors and BKCa channels. Circ Res 97, 1270-1279.
32. Earley, S., Pauyo, T., Drapp, R., Tavares, M.J., Liedtke, W. & Brayden, J.E. 2009. TRPV4-dependent dilation of peripheral resistance arteries influences arterial pressure. Am J Physiol Heart Circ Physiol 297, H1096-H1102.
33. Earley, S., Gonzales, A.L. & Garcia, Z.I. 2010. A dietary agonist of transient receptor potential cation channel V3 elicits endothelium-dependent vasodilation. Mol Pharmacol 77, 612-620.
34. Edwards, G., Félétou, M. & Weston, A. 2010. Endothelium-derived hyperpolarising factors and associated pathways: a synopsis. Pflügers Archiv Eur J Physiol 459, 863-879.
35. Erler, I., Hirnet, D., Wissenbach, U., Flockerzi, V. & Niemeyer, B.A. 2004. Ca2+-selective transient receptor potential V channel architecture and function require a specific ankyrin repeat. J Biol Chem, 279, 34456-34463.
36. Everaerts, W., Sepúlveda, M., Gevaert, T., Roskams, T., Nilius, B. & De Ridder, D. 2009. Where is TRPV1 expressed in the bladder, do we see the real channel? Naunyn-Schmiedebergs Arch Pharmacol 379, 421-425.
37. Everaerts, W., Vriens, J., Owsianik, G., Appendino, G., Voets, T., De Ridder, D. & Nilius, B. 2010. Functional characterization of transient receptor potential channels in mouse urothelial cells. Am J Physiol Renal Physiol 298, F692-F701.
38. 2+ entry in human pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol 285, L1233-L1245.
39. Félétou, M. & Vanhoutte, P. 2009. EDHF: an update. Clin Sci 117, 139-155.
40. Feng, N.-H., Lee, H.-H., Shiang, J.-C. & Ma, M.-C. 2008. Transient receptor potential vanilloid type 1 channels act as mechanoreceptors and cause substance P release and sensory activation in rat kidneys. Am J Physiol Renal Physiol 294, F316-F325.
41. Fernandes, J., Lorenzo, I.M., Andrade, Y.N., Garcia-Elias, A., Serra, S.A., Fernandez-Fernandez, J. & Valverde, M.A. 2008. IP3 sensitizes TRPV4 channel to the mechano- and osmotransducing messenger 5'-6'-epoxyeicosatrienoic acid. J Cell Biol 181, 143-155.
42. Flockerzi, V., Nilius, B., Plant, T. & Strotmann, R. 2007. TRPV4. In: K. Starke, G.V.R. Born, S.P. Duckles, M. Eichelbaum, D. Ganten, F. Hofmann et al. (Eds.) Transient Receptor Potential (TRP) Channels. Springer, Berlin Heidelberg.
43. 2+-activated K+ channels and sensory nerves. J Hypertens 28, 102-110.
44. Gao, X., Wu, L. & O'Neil, R.G. 2003. Temperature-modulated diversity of TRPV4 channel gating: activation by physical stresses and phorbol ester derivatives through protein kinase C-dependent and -independent pathways. J Biol Chem, 278, 27129-27137.
45. Gao, F., Sui, D., Garavito, R.M., Worden, R.M. & Wang, D.H. 2009. Salt intake augments hypotensive effects of transient receptor potential vanilloid 4: functional significance and implication. Hypertension 53, 228-235.
46. Garcia-Elias, A., Lorenzo, I.M., Vicente, R.N. & Valverde, M.A. 2008. IP3 receptor binds to and sensitizes TRPV4 channel to osmotic stimuli via a calmodulin-binding site. J Biol Chem 283, 31284-31288.
47. Garcia-Martinez, C., Morenilla-Palao, C., Planells-Cases, R., Merino, J.M. & Ferrer-Montiel, A. 2000. Identification of an aspartic residue in the P-loop of the vanilloid receptor that modulates pore properties. J Biol Chem, 275, 32552-32558.
48. Garcia-Sanz, N., Fernandez-Carvajal, A., Morenilla-Palao, C., Planells-Cases, R., Fajardo-Sanchez, E., Fernandez-Ballester, G. & Ferrer-Montiel, A. 2004. Identification of a tetramerization domain in the C terminus of the vanilloid receptor. J Neurosci 24, 5307-5314.
49. Garcia-Sanz, N., Valente, P., Gomis, A., Fernandez-Carvajal, A., Fernandez-Ballester, G., Viana, F., Belmonte, C. & Ferrer-Montiel, A. 2007. A role of the transient receptor potential domain of vanilloid receptor I in channel gating. J Neurosci 27, 11641-11650.
50. Golech, S.A., McCarron, R.M., Chen, Y., Bembry, J., Lenz, F., Mechoulam, R., Shohami, E. & Spatz, M. 2004. Human brain endothelium: coexpression and function of vanilloid and endocannabinoid receptors. Mol Brain Res 132, 87-92.
51. Grandl, J., Hu, H., Bandell, M., Bursulaya, B., Schmidt, M., Petrus, M. & Patapoutian, A. 2008. Pore region of TRPV3 ion channel is specifically required for heat activation. Nat Neurosci, 11, 1007-1013.
52. Grant, A.D., Cottrell, G.S., Amadesi, S., Trevisani, M., Nicoletti, P., Materazzi, S., Altier, C., Cenac, N., Zamponi, G.W., Bautista-Cruz, F. et al. 2007. Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice. J Physiol 578, 715-733.
53. Guler, A.D. 2002. Heat-evoked activation of the ion channel, TRPV4. J Neurosci 22, 6408-6814.
54. Han, S.-P., Naes, L. & Westfall, T.C. 1990. Inhibition of periarterial nerve stimulation-induced vasodilation of the mesenteric arterial bed by CGRP (8-37) and CGRP receptor desensitization. Biochem Biophys Res Commun 168, 786-791.
55. Hartmannsgruber, V., Heyken, W.-T., Kacik, M., Kaistha, A., Grgic, I., Harteneck, C., Liedtke, W., Hoyer, J. & Köhler, R. 2007. Arterial response to shear stress critically depends on endothelial TRPV4 expression. PLoS ONE 2, e827.
56. Hellwig, N., Albrecht, N., Harteneck, C., Schultz, G. & Schaefer, M. 2005. Homo- and heteromeric assembly of TRPV channel subunits. J Cell Sci, 118, 917-928.
57. Hiura, A. 2009. Is thermal nociception only sensed by the capsaicin receptor, TRPV1? Anat Sci Int, 84, 122-128.
58. Hoenderop, J.G.J., Voets, T., Hoefs, S., Weidema, F., Prenen, J., Nilius, B. & Bindels, R.J.M. 2003. Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6. EMBO J, 22, 776-785.
59. Hoi, P.M., Visintin, C., Okuyama, M., Gardiner, S.M., Kaup, S.S., Bennett, T., Baker, D., Selwood, D.L. & R, H.C. 2007. Vascular pharmacology of a novel cannabinoid-like compound, 3-(5-dimethylcarbamoyl-pent-1-enyl)-N-(2-hydroxy-1-methyl-ethyl)benzamide (VSN16) in the rat. Br J Pharmacol 152, 751-764.
60. Iida, T., Shimizu, I., Nealen, M.L., Campbell, A. & Caterina, M. 2005. Attenuated fever response in mice lacking TRPV1. Neurosci Lett, 378, 28-33.
61. Inoue, R., Jensen, L.J., Shi, J., Morita, H., Nishida, M., Honda, A. & Ito, Y. 2006. Transient receptor potential channels in cardiovascular function and disease. Circ Res 99, 119-131.
62. Jin, X., Touhey, J. & Gaudet, R. 2006. Structure of the N-terminal Ankyrin Repeat Domain of the TRPV2 ion channel. J Biol Chem, 281, 25006-25010.
63. Johansson, B. 1989. Myogenic tone and reactivity: definitions based on muscle physiology. J Hypertens Suppl 7, S5-S8.
64. Kark, T.S., Bagi, Z., Lizanecz, E.B., Pasztor, E.T., Erdei, N.R., Czikora, Ã.G., Papp, Z.N., Edes, I.N., Porszasz, R.B. & Toth, A. 2008. Tissue-specific regulation of microvascular diameter: opposite functional roles of neuronal and smooth muscle located vanilloid receptor-1. Mol Pharmacol 73, 1405-1412.
65. Kedei, N., Szabo, T., Lile, J.D., Treanor, J.J., Olah, Z., Iadarola, M.J. & Blumberg, P.M. 2001. Analysis of the native quaternary structure of vanilloid receptor 1. J Biol Chem, 276, 28613-28619.
66. Klausen, T.K.r., Pagani, A., Minassi, A., Ech-Chahad, A., Prenen, J., Owsianik, G., Hoffmann, E.K., Pedersen, S.F., Appendino, G. & Nilius, B. 2009. Modulation of the transient receptor potential vanilloid channel TRPV4 by 4alpha-phorbol esters: a structure-activity study. J Med Chem, 52, 2933-2939.
67. Köhler, R. & Ruth, P. 2010. Endothelial dysfunction and blood pressure alterations in K+-channel transgenic mice. Pflügers Archiv Eur J Physiol 459, 969-976.
68. Kohler, R., Heyken, W.-T., Heinau, P., Schubert, R., Si, H., Kacik, M., Busch, C., Grgic, I., Maier, T. & Hoyer, J. 2006. Evidence for a functional role of endothelial transient receptor potential V4 in shear stress-induced vasodilatation. Arterioscler Thromb Vasc Biol 26, 1495-1502.
69. Kottgen, M., Buchholz, B.R., Garcia-Gonzalez, M.A., Kotsis, F., Fu, X., Doerken, M., Boehlke, C., Steffl, D., Tauber, R., Wegierski, T. et al. 2008. TRPP2 and TRPV4 form a polymodal sensory channel complex. J Cell Biol 182, 437-447.
70. Landoure, G., Zdebik, A.A., Martinez, T.L., Burnett, B.G., Stanescu, H.C., Inada, H., Shi, Y., Taye, A.A., Kong, L., Munns, C.H. et al. 2010. Mutations in TRPV4 cause Charcot-Marie-tooth disease type 2C. Nat Genet 42, 170-174.
71. Latorre, R., Zaelzer, C. & Brauchi, S. 2009. Structure-functional intimacies of transient receptor potential channels. Q Rev Biophys 42, 201-246.
72. Lee, H., Iida, T., Mizuno, A., Suzuki, M. & Caterina, M.J. 2005. Altered thermal selection behavior in mice lacking transient receptor potential vanilloid 4. J Neurosci 25, 1304-1310.
73. Leffler, A., Fischer, M.J., Rehner, D., Kienel, S., Kistner, K., Sauer, S.K., Gavva, N.R., Reeh, P.W. & Nau, C. 2008. The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons. J Clin Invest 118, 763-776.
74. Liedtke, W. & Friedman, J.M. 2003. Abnormal osmotic regulation in trpv4-/- mice. Proc Natl Acad Sci USA 100, 13698-13703.
75. Liedtke, W., Choe, Y., Martí-Renom, M.A., Bell, A.M., Denis, C.S., Sali, A., Hudspeth, A.J., Friedman, J.M. & Heller, S. 2000. Vanilloid receptor-related osmotically activated channel (VR-OAC), a candidate vertebrate osmoreceptor. Cell 103, 525-535.
76. Liedtke, W., Tobin, D.M., Bargmann, C.I. & Friedman, J.M. 2003. Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans. Proc Natl Acad Sci USA 100, 14531-14536.
77. Lishko, P.V., Procko, E., Jin, X., Phelps, C.B. & Gaudet, R. 2007. The Ankyrin Repeats of TRPV1 bind multiple ligands and modulate channel sensitivity. Neuron, 54, 905-918.
78. Liu, B., Ma, W., Ryu, S. & Qin, F. 2004. Inhibitory modulation of distal C-terminal on protein kinase C-dependent phospho-regulation of rat TRPV1 receptors. J Physiol 560, 627-638.
79. Loot, A.E., Popp, R.D., Fisslthaler, B., Vriens, J., Nilius, B. & Fleming, I. 2008. Role of cytochrome P450-dependent transient receptor potential V4 activation in flow-induced vasodilatation. Cardiovasc Res 80, 445-452.
80. Loukin, S.H., Su, Z. & Kung, C. 2009. Hypotonic shocks activate rat TRPV4 in yeast in the absence of polyunsaturated fatty acids. FEBS Lett 583, 754-758.
81. Loukin, S., Zhou, X., Su, Z., Saimi, Y. & Kung, C. 2010. Wild-type and Brachyolmia-causing mutant TRPV4 channels respond directly to stretch force. J Biol Chem 285, 27176-27181.
82. Marrelli, S.P., O'Neil, R.G., Brown, R.C. & Bryan, R.M. Jr 2007. PLA2 and TRPV4 channels regulate endothelial calcium in cerebral arteries. Am J Physiol Heart Circ Physiol 292, H1390-H1397.
83. McCleverty, C.J., Koesema, E., Patapoutian, A., Lesley, S.A. & Kreusch, A. 2006. Crystal structure of the human TRPV2 channel ankyrin repeat domain. Protein Sci, 15, 2201-2206.
84. McHugh, J., Keller, N.R., Appalsamy, M., Thomas, S.A., Raj, S.R., Diedrich, A., Biaggioni, I., Jordan, J. & Robertson, D. 2010. Portal osmopressor mechanism linked to transient receptor potential vanilloid 4 and blood pressure control. Hypertension 55, 1438-1443.
85. 2+ influx and vasodilation in response to shear stress. Am J Physiol Heart Circ Physiol 298, H466-H476.
86. Mishra, S.K. & Hoon, M.A. 2010. Ablation of TrpV1 neurons reveals their selective role in thermal pain sensation. Mol Cell Neurosci, 43, 157-163.
87. Mizoguchi, F., Mizuno, A., Hayata, T., Nakashima, K., Heller, S., Ushida, T., Sokabe, M., Miyasaka, N., Suzuki, M., Ezura, Y. & Noda, M. 2008. Transient receptor potential vanilloid 4 deficiency suppresses unloading-induced bone loss. J Cell Physiol 216, 47-53.
88. Moqrich, A., Hwang, S.W., Earley, T.J., Petrus, M.J., Murray, A.N., Spencer, K.S.R., Andahazy, M., Story, G.M. & Patapoutian, A. 2005. Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin. Science 307, 1468-1472.
89. Muraki, K., Iwata, Y., Katanosaka, Y., Ito, T., Ohya, S., Shigekawa, M. & Imaizumi, Y. 2003. TRPV2 is a component of osmotically sensitive cation channels in murine aortic myocytes. Circ Res 93, 829-838.
90. Naeini, R.S., Witty, M.-F., Seguela, P. & Bourque, C.W. 2006. An N-terminal variant of Trpv1 channel is required for osmosensory transduction. Nat Neurosci 9, 93-98.
91. Nelson, M.T., Cheng, H., Rubart, M., Santana, L.F., Bonev, A.D., Knot, H.J. & Lederer, W.J. 1995. Relaxation of arterial smooth muscle by calcium sparks. Science, 270, 633-637.
92. Nilius, B., Prenen, J., Wissenbach, U., Bödding, M. & Droogmans, G. 2001. Differential activation of the volume-sensitive cation channel TRP12 (OTRPC4) and volume-regulated anion currents in HEK-293 cells. Pflügers Archiv Eur J Physiol 443, 227-233.
93. Nilius, B., Owsianik, G., Voets, T. & Peters, J.A. 2007. Transient receptor potential cation channels in disease. Physiol Rev, 87, 165-217.
94. Offertaler, L.S., Mo, F.-M., Bátkai, S.N., Liu, J., Begg, M., Razdan, R.K., Martin, B.R., Bukoski, R.D. & Kunos, G. 2003. Selective ligands and cellular effectors of a G protein-coupled endothelial cannabinoid receptor. Mol Pharmacol 63, 699-705.
95. O'Neil, R.G. & Heller, S. 2005. The mechanosensitive nature of TRPV channels. Pflugers Arch 451, 193-203.
96. Pacher, P., Batkai, S. & Kunos, G. 2004. Haemodynamic profile and responsiveness to anandamide of TRPV1 receptor knock-out mice. J Physiol 558, 647-657.
97. Phelps, C., Procko, E., Lishko, P., Wang, R. & Gaudet, R. 2007. Insights into the roles of conserved and divergent residues in the ankyrin repeats of TRPV channels. Channels, 1, 148-151.
98. Poblete, I.S.M., Orliac, M.A.L., Briones, R., Adler-Graschinsky, E. & Huidobro-Toro, J.P. 2005. Anandamide elicits an acute release of nitric oxide through endothelial TRPV1 receptor activation in the rat arterial mesenteric bed. J Physiol 568, 539-551.
99. Pozsgai, G., Bodkin, J.V., Graepel, R., Bevan, S., Andersson, D.A. & Brain, S.D. 2010. Evidence for the pathophysiological relevance of TRPA1 receptors in the cardiovascular system in vivo. Cardiovasc Res 87, 760-768.
100. Qin, N., Neeper, M.P., Liu, Y., Hutchinson, T.L., Lubin, M.L. & Flores, C.M. 2008. TRPV2 is activated by cannabidiol and mediates CGRP release in cultured rat dorsal root ganglion neurons. J Neurosci 28, 6231-6238.
101. Rock, M.J., Prenen, J., Funari, V.A., Funari, T.L., Merriman, B., Nelson, S.F., Lachman, R.S., Wilcox, W.R., Reyno, S., Quadrelli, R. et al. 2008. Gain-of-function mutations in TRPV4 cause autosomal dominant brachyolmia. Nat Genet 40, 999-1003.
102. Rohacs, T. 2009. Phosphoinositide regulation of non-canonical transient receptor potential channels. Cell Calcium 45, 554-565.
103. Rohacs, T., Lopes, C.M.B., Michailidis, I. & Logothetis, D.E. 2005. PI(4, 5)P2 regulates the activation and desensitization of TRPM8 channels through the TRP domain. Nat Neurosci 8, 626-634.
104. Romanovsky, A.A., Almeida, M.C., Garami, A., Steiner, A.A., Norman, M.H., Morrison, S.F., Nakamura, K., Burmeister, J.J. & Nucci, T.B. 2009. The transient receptor potential vanilloid-1 channel in thermoregulation: a thermosensor it is not. Pharmacol Rev, 61, 228-261.
105. Rong, W., Hillsley, K., Davis, J.B., Hicks, G., Winchester, W.J. & Grundy, D. 2004. Jejunal afferent nerve sensitivity in wild-type and TRPV1 knockout mice. J Physiol 560, 867-881.
106. Rutter, A.R., Ma, Q.-P., Leveridge, M. & Bonnert, T.P. 2005. Heteromerization and colocalization of TrpV1 and TrpV2 in mammalian cell lines and rat dorsal root ganglia. Neuroreport, 16, 1735-1739.
107. 2+ signals and gap junction function are regulated by caveolin in endothelial cells. Circulation 117, 1065-1074.
108. Scotland, R.S., Chauhan, S., Davis, C., De Felipe, C., Hunt, S., Kabir, J., Kotsonis, P., Oh, U. & Ahluwalia, A. 2004. Vanilloid receptor TRPV1, sensory C-fibers, and vascular autoregulation: a novel mechanism involved in myogenic constriction. Circ Res 95, 1027-1034.
109. Smith, G.D., Gunthorpe, M.J., Kelsell, R.E., Hayes, P.D., Reilly, P., Facer, P., Wright, J.E., Jerman, J.C., Walhin, J.P., Ooi, L. et al. 2002. TRPV3 is a temperature-sensitive vanilloid receptor-like protein. Nature 418, 186-190.
110. Smith, P.L., Maloney, K.N., Pothen, R.G., Clardy, J. & Clapham, D.E. 2006. Bisandrographolide from Andrographis paniculata activates TRPV4 channels. J Biol Chem 281, 29897-29904.
111. Stewart, A.P., Smith, G.D., Sandford, R.N. & Edwardson, J.M. 2010. Atomic force microscopy reveals the alternating subunit arrangement of the TRPP2-TRPV4 heterotetramer. Biophys J, 99, 790-797.
112. Stokes, A.J., Wakano, C., Carmen, K.A.D., Koblan-Huberson, M. & Turner, H. 2005. Formation of a physiological complex between TRPV2 and RGA protein promotes cell surface expression of TRPV2. J Cell Biochem 94, 669-683.
113. Strotmann, R., Harteneck, C., Nunnenmacher, K., Schultz, G. & Plant, T. 2000. OTRPC4, a nonselective cation channel that confers sensitivity to extracellular osmolarity. Nat Cell Biol 2, 695-702.
114. Sun, H., Li, D.P., Chen, S.R., Hittelman, W.N. & Pan, H.L. 2009. Sensing of blood pressure increase by transient receptor potential vanilloid 1 receptors on baroreceptors. J Pharmacol Exp Ther, 331, 851-859.
115. Suzuki, M., Mizuno, A., Kodaira, K. & Imai, M. 2003a. Impaired pressure sensation with mice lacking TRPV4. J Biol Chem 278, 22664-22668.
116. Suzuki, M., Watanabe, Y., Oyama, Y., Mizuno, A., Kusano, E., Hirao, A. & Ookawara, S. 2003b. Localization of mechanosensitive channel TRPV4 in mouse skin. Neurosci Lett 353, 189-192.
117. Tanaka, R., Muraki, K., Ohya, S., Yamamura, H., Hatano, N., Itoh, Y. & Imaizumi, Y. 2008. TRPV4-like non-selective cation currents in cultured aortic myocytes. J Pharmacol Sci 108, 179-189.
118. Thodeti, C.K., Matthews, B., Ravi, A., Mammoto, A., Ghosh, K., Bracha, A.L. & Ingber, D.E. 2009. TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling. Circ Res 104, 1123-1130.
119. Thorneloe, K.S., Sulpizio, A.C., Lin, Z., Figueroa, D.J., Clouse, A.K., McCafferty, G.P., Chendrimada, T.P., Lashinger, E.S.R., Gordon, E., Evans, L. et al. 2008. N-((1S)-1-{[4-((2S)-2-{[(2, 4-Dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a novel and potent transient receptor potential vanilloid 4 channel agonist induces urinary bladder contraction and hyperactivity: part I. J Pharmacol Exp Ther 326, 432-442.
120. Todaka, H., Taniguchi, J., Satoh, J.-I., Mizuno, A. & Suzuki, M. 2004. Warm temperature-sensitive transient receptor potential vanilloid 4 (TRPV4) plays an essential role in thermal hyperalgesia. J Biol Chem 279, 35133-35138.
121. Tominaga, M., Caterina, M.J., Malmberg, A.B., Rosen, T.A., Gilbert, H., Skinner, K., Raumann, B.E., Basbaum, A.I. & Julius, D. 1998. The cloned capsaicin receptor integrates multiple pain-producing stimuli. Neuron 21, 531-543.
122. Tóth, A., Boczán, J., Kedei, N., Lizanecz, E., Bagi, Z., Papp, Z., Édes, I., Csiba, L. & Blumberg, P.M. 2005. Expression and distribution of vanilloid receptor 1 (TRPV1) in the adult rat brain. Mol Brain Res 135, 162-168.
123. Vanhoutte, P.M., Shimokawa, H., Tang, E.H.C. & Feletou, M. 2009. Endothelial dysfunction and vascular disease. Acta Physiol 196, 193-222.
124. Vannier, B., Zhu, X., Brown, D. & Birnbaumer, L. 1998. The membrane topology of human transient receptor potential 3 as inferred from glycosylation-scanning mutagenesis and epitope immunocytochemistry. J Biol Chem, 273, 8675-8679.
125. Venkatachalam, K. & Montell, C. 2007. TRP channels. Annu Rev Biochem, 76, 387-417.
126. Vilceanu, D., Honore, P., Hogan, Q.H. & Stucky, C.L. 2010. Spinal nerve ligation in mouse upregulates TRPV1 heat function in injured IB4-positive nociceptors. J Pain 11, 588-599.
127. Vincent, F., Acevedo, A., Nguyen, M.T., Dourado, M., DeFalco, J., Gustafson, A., Spiro, P., Emerling, D.E., Kelly, M.G. & Duncton, M.A.J. 2009. Identification and characterization of novel TRPV4 modulators. Biochem Biophys Res Commun 389, 490-494.
128. Voets, T., Prenen, J., Vriens, J., Watanabe, H., Janssens, A., Wissenbach, U., Bodding, M., Droogmans, G. & Nilius, B. 2002. Molecular determinants of permeation through the cation channel TRPV4. J Biol Chem 277, 33704-33710.
129. Voets, T., Janssens, A., Prenen, J., Droogmans, G. & Nilius, B. 2003. Mg2+-dependent gating and strong inward rectification of the cation channel TRPV6. J Gen Physiol, 121, 245-260.
130. Voets, T., Droogmans, G., Wissenbach, U., Janssens, A., Flockerzi, V. & Nilius, B. 2004. The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels. Nature 430, 748-754.
131. Vriens, J., Watanabe, H., Janssens, A., Droogmans, G., Voets, T. & Nilius, B. 2004. Cell swelling, heat, and chemical agonists use distinct pathways for the activation of the cation channel TRPV4. Proc Natl Acad Sci USA 101, 396-401.
132. 2 permeable cation channel TRPV4 by cytochrome P450 epoxygenases in vascular endothelium. Circ Res 97, 908-915.
133. Vriens, J., Owsianik, G., Janssens, A., Voets, T. & Nilius, B. 2007. Determinants of 4alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4. J Biol Chem, 282, 12796-12803.
134. Vriens, J., Appendino, G. & Nilius, B. 2009. Pharmacology of Vanilloid Transient Receptor Potential Cation Channels. Mol Pharmacol, 75, 1262-1279.
135. Wang, Y. & Wang, D.H. 2009. Aggravated renal inflammatory responses in TRPV1 gene knockout mice subjected to DOCA-salt hypertension. Am J Physiol Renal Physiol 297, F1550-F1559.
136. Wang, L.H., Luo, M., Wang, Y., Galligan, J.J. & Wang, D.H. 2006. Impaired vasodilation in response to perivascular nerve stimulation in mesenteric arteries of TRPV1-null mutant mice. J Hypertens 24, 2399-2408.
137. Wang, Y., Wang, J., Wang, C., Liu, J., Shi, L., Xu, M. & Wang, C. 2008. Functional expression of transient receptor potential vanilloid-related channels in chronically hypoxic human pulmonary arterial smooth muscle cells. J Membr Biol 223, 151-159.
138. Watanabe, H. 2002a. Activation of TRPV4 channels (hVRL-2/mTRP12) by phorbol derivatives. J Biol Chem 277, 13569-13577.
139. Watanabe, H. 2002b. Heat-evoked activation of TRPV4 channels in a HEK293 cell expression system and in native mouse aorta endothelial cells. J Biol Chem 277, 47044-47051.
140. Watanabe, H., Vriens, J., Prenen, J., Droogmans, G., Voets, T. & Nilius, B. 2003. Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels. Nature 424, 434-438.
141. Wegierski, T., Lewandrowski, U., Muller, B., Sickmann, A. & Walz, G. 2009. Tyrosine phosphorylation modulates the activity of TRPV4 in response to defined stimuli. J Biol Chem 284, 2923-2933.
142. Willette, R.N., Bao, W., Nerurkar, S., Yue, T.-L., Doe, C.P., Stankus, G., Turner, G.H., Ju, H., Thomas, H., Fishman, C.E. et al. 2008. Systemic activation of the transient receptor potential vanilloid subtype 4 channel causes endothelial failure and circulatory collapse: part 2. J Pharmacol Exp Ther 326, 443-452.
143. Woodbury, C.J., Zwick, M., Wang, S., Lawson, J.J., Caterina, M.J., Koltzenburg, M., Albers, K.M., Koerber, H.R. & Davis, B.M. 2004. Nociceptors lacking TRPV1 and TRPV2 have normal heat responses. J Neurosci 24, 6410-6415.
144. Wu, M., Komori, N., Qin, C., Farber, J.P., Linderoth, B. & Foreman, R.D. 2006. Sensory fibers containing vanilloid receptor-1 (VR-1) mediate spinal cord stimulation-induced vasodilation. Brain Res, 1107, 177-184.
145. 2+-activated K+ channel, IKCa1: a potential immunosuppressant. Proc Natl Acad Sci USA 97, 8151-8156.
146. Xu, H. 2002. TRPV3 is a calcium-permeable temperature-sensitive cation channel. Nature 418, 181-186.
147. Xu, H., Zhao, H., Tian, W., Yoshida, K., Roullet, J.-B. & Cohen, D.M. 2003. Regulation of a transient receptor potential (TRP) channel by tyrosine phosphorylation. SRC family kinase-dependent tyrosine phosphorylation of TRPV4 on TYR-253 mediates its response to hypotonic stress. J Biol Chem, 278, 11520-11527.
148. Yang, X.R., Lin, M.J., McIntosh, L.S. & Sham, J.S. 2006. Functional expression of transient receptor potential melastatin- and vanilloid-related channels in pulmonary arterial and aortic smooth muscle. Am J Physiol Lung Cell Mol Physiol 290, L1267-L1276.
149. Yang, F., Cui, Y., Wang, K. & Zheng, J. 2010a. Thermosensitive TRP channel pore turret is part of the temperature activation pathway. Proc Natl Acad Sci USA, 107, 7083-7088.
150. Yang, D., Luo, Z., Ma, S., Wong, W.T., Ma, L., Zhong, J., He, H., Zhao, Z., Cao, T., Yan, Z., Liu, D., Arendshorst, W.J., Huang, Y., Tepel, M. & Zhu, Z. 2010b. Activation of TRPV1 by dietary capsaicin improves endothelium-dependent vasorelaxation and prevents hypertension. Cell Metab 12, 130-141.
151. Ye, F., Deng, P.-Y., Li, D., Luo, D., Li, N.-S., Deng, S., Deng, H.-W. & Li, Y.-J. 2007. Involvement of endothelial cell-derived CGRP in heat stress-induced protection of endothelial function. Vascul Pharmacol 46, 238-246.
152. Yin, J. & Kuebler, W. 2010. Mechanotransduction by TRP channels: general concepts and specific role in the vasculature. Cell Biochem Biophys 56, 1-18.
153. Zhang, D.X., Mendoza, S.A., Bubolz, A.H., Mizuno, A., Ge, Z.-D., Li, R., Warltier, D.C., Suzuki, M. & Gutterman, D.D. 2009. Transient receptor potential vanilloid type 4-deficient mice exhibit impaired endothelium-dependent relaxation induced by acetylcholine in vitro and in vivo. Hypertension 53, 532-538.
154. Zimon, M., Baets, J., Auer-Grumbach, M., Berciano, J., Garcia, A., Lopez-Laso, E., Merlini, L., Hilton-Jones, D., McEntagart, M., Crosby, A.H. et al. 2010. Dominant mutations in the cation channel gene transient receptor potential vanilloid 4 cause an unusual spectrum of neuropathies. Brain 133, 1798-1809.