메뉴 건너뛰기




Volumn 7, Issue APR, 2017, Pages

Metabolic cooperation and competition in the tumor microenvironment: Implications for therapy

Author keywords

Cancer cell metabolism; Cancer associated fibroblasts; Immune network; Metabolic cooperation; Metabolic reprogramming; Tumor microenvironment; Warburg effect

Indexed keywords

GLUTAMINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 17; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROGRAMMED DEATH 1 LIGAND 1; PROGRAMMED DEATH 1 RECEPTOR; PROTEIN KINASE B;

EID: 85019037006     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2017.00068     Document Type: Article
Times cited : (149)

References (338)
  • 1
    • 0004154783 scopus 로고
    • The Metabolism of Tumors
    • London: Constable and Co
    • Warburg O. The Metabolism of Tumors. London: Constable and Co. (1930).
    • (1930)
    • Warburg, O.1
  • 2
    • 84899713732 scopus 로고    scopus 로고
    • Tumor microenvironment and metabolic synergy in breast cancers: critical importance of mitochondrial fuels and function
    • Martinez-Outschoorn U, Sotgia F, Lisanti MP. Tumor microenvironment and metabolic synergy in breast cancers: critical importance of mitochondrial fuels and function. Semin Oncol (2014) 41:195-216. doi:10.1053/j.seminoncol.2014.03.002
    • (2014) Semin Oncol , vol.41 , pp. 195-216
    • Martinez-Outschoorn, U.1    Sotgia, F.2    Lisanti, M.P.3
  • 3
    • 84880120014 scopus 로고    scopus 로고
    • Cancer-generated lactic acid: a regulatory, immunosuppressive metabolite?
    • Choi SY, Collins CC, Gout PW, Wang Y. Cancer-generated lactic acid: a regulatory, immunosuppressive metabolite? J Pathol (2013) 230:350-5. doi:10.1002/path.4218
    • (2013) J Pathol , vol.230 , pp. 350-355
    • Choi, S.Y.1    Collins, C.C.2    Gout, P.W.3    Wang, Y.4
  • 4
    • 84876758617 scopus 로고    scopus 로고
    • Metabolic pathways in immune cell activation and quiescence
    • Pearce EL, Pearce EJ. Metabolic pathways in immune cell activation and quiescence. Immunity (2013) 38:633-43. doi:10.1016/j.immuni.2013.04.005
    • (2013) Immunity , vol.38 , pp. 633-643
    • Pearce, E.L.1    Pearce, E.J.2
  • 5
    • 84947591002 scopus 로고    scopus 로고
    • T cell metabolism drives immunity
    • Buck MD, O'Sullivan D, Pearce EL. T cell metabolism drives immunity. J Exp Med (2015) 212:1345-60. doi:10.1084/jem.20151159
    • (2015) J Exp Med , vol.212 , pp. 1345-1360
    • Buck, M.D.1    O'Sullivan, D.2    Pearce, E.L.3
  • 6
    • 84961290082 scopus 로고    scopus 로고
    • Targeting T cell metabolism for therapy
    • O'Sullivan D, Pearce EL. Targeting T cell metabolism for therapy. Trends Immunol (2015) 36:71-80. doi:10.1016/j.it.2014.12.004
    • (2015) Trends Immunol , vol.36 , pp. 71-80
    • O'Sullivan, D.1    Pearce, E.L.2
  • 7
    • 84904392273 scopus 로고    scopus 로고
    • Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development
    • O'Sullivan D, van der Windt GJ, Huang SC, Curtis JD, Chang CH, Buck MD, et al. Memory CD8(+) T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development. Immunity (2014) 41:75-88. doi:10.1016/j.immuni.2014.06.005
    • (2014) Immunity , vol.41 , pp. 75-88
    • O'Sullivan, D.1    van der Windt, G.J.2    Huang, S.C.3    Curtis, J.D.4    Chang, C.H.5    Buck, M.D.6
  • 8
    • 58949092790 scopus 로고    scopus 로고
    • The tumor microenvironment and metastatic disease
    • Lunt SJ, Chaudary N, Hill RP. The tumor microenvironment and metastatic disease. Clin Exp Metastasis (2009) 26:19-34. doi:10.1007/s10585-008-9182-2
    • (2009) Clin Exp Metastasis , vol.26 , pp. 19-34
    • Lunt, S.J.1    Chaudary, N.2    Hill, R.P.3
  • 9
    • 79251517382 scopus 로고    scopus 로고
    • Regulation of cancer cell metabolism
    • Cairns RA, Harris IS, Mak TW. Regulation of cancer cell metabolism. Nat Rev Cancer (2011) 11:85-95. doi:10.1038/nrc2981
    • (2011) Nat Rev Cancer , vol.11 , pp. 85-95
    • Cairns, R.A.1    Harris, I.S.2    Mak, T.W.3
  • 10
    • 84055225365 scopus 로고    scopus 로고
    • Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis
    • Pavlides S, Vera I, Gandara R, Sneddon S, Pestell RG, Mercier I, et al. Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis. Antioxid Redox Signal (2012) 16:1264-84. doi:10.1089/ars.2011.4243
    • (2012) Antioxid Redox Signal , vol.16 , pp. 1264-1284
    • Pavlides, S.1    Vera, I.2    Gandara, R.3    Sneddon, S.4    Pestell, R.G.5    Mercier, I.6
  • 11
    • 85007572959 scopus 로고    scopus 로고
    • Clinical relevance of the tumor microenvironment and immune escape of oral squamous cell carcinoma
    • Eckert AW, Wickenhauser C, Salins PC, Kappler M, Bukur J, Seliger B. Clinical relevance of the tumor microenvironment and immune escape of oral squamous cell carcinoma. J Transl Med (2016) 14:85. doi:10.1186/s12967-016-0828-6
    • (2016) J Transl Med , vol.14 , pp. 85
    • Eckert, A.W.1    Wickenhauser, C.2    Salins, P.C.3    Kappler, M.4    Bukur, J.5    Seliger, B.6
  • 13
    • 84964665975 scopus 로고    scopus 로고
    • Intrinsic and tumor microenvironment-induced metabolism adaptations of T cells and impact on their differentiation and function
    • Kouidhi S, Noman MZ, Kieda C, Elgaaied AB, Chouaib S. Intrinsic and tumor microenvironment-induced metabolism adaptations of T cells and impact on their differentiation and function. Front Immunol (2016) 7:114. doi:10.3389/fimmu.2016.00114
    • (2016) Front Immunol , vol.7 , pp. 114
    • Kouidhi, S.1    Noman, M.Z.2    Kieda, C.3    Elgaaied, A.B.4    Chouaib, S.5
  • 14
    • 84871821537 scopus 로고    scopus 로고
    • Metabolic changes in cancer: beyond the Warburg effect
    • Wu W, Zhao S. Metabolic changes in cancer: beyond the Warburg effect. Acta Biochim Biophys Sin (Shanghai) (2013) 45:18-26. doi:10.1093/abbs/gms104
    • (2013) Acta Biochim Biophys Sin (Shanghai) , vol.45 , pp. 18-26
    • Wu, W.1    Zhao, S.2
  • 15
    • 84905673351 scopus 로고    scopus 로고
    • The intercellular metabolic interplay between tumor and immune cells
    • Wang T, Liu G, Wang R. The intercellular metabolic interplay between tumor and immune cells. Front Immunol (2014) 5:358. doi:10.3389/fimmu.2014.00358
    • (2014) Front Immunol , vol.5 , pp. 358
    • Wang, T.1    Liu, G.2    Wang, R.3
  • 16
    • 84926514026 scopus 로고    scopus 로고
    • T cell metabolic fitness in antitumor immunity
    • Siska PJ, Rathmell JC. T cell metabolic fitness in antitumor immunity. Trends Immunol (2015) 36:257-64. doi:10.1016/j.it.2015.02.007
    • (2015) Trends Immunol , vol.36 , pp. 257-264
    • Siska, P.J.1    Rathmell, J.C.2
  • 17
    • 84964682256 scopus 로고    scopus 로고
    • Targeting metabolic symbiosis to overcome resistance to anti-angiogenic therapy
    • Pisarsky L, Bill R, Fagiani E, Dimeloe S, Goosen RW, Hagmann J, et al. Targeting metabolic symbiosis to overcome resistance to anti-angiogenic therapy. Cell Rep (2016) 15:1161-74. doi:10.1016/j.celrep.2016.04.028
    • (2016) Cell Rep , vol.15 , pp. 1161-1174
    • Pisarsky, L.1    Bill, R.2    Fagiani, E.3    Dimeloe, S.4    Goosen, R.W.5    Hagmann, J.6
  • 18
    • 84876115558 scopus 로고    scopus 로고
    • Metabolic symbiosis in cancer: refocusing the Warburg lens
    • Nakajima EC, Van Houten B. Metabolic symbiosis in cancer: refocusing the Warburg lens. Mol Carcinog (2013) 52:329-37. doi:10.1002/mc.21863
    • (2013) Mol Carcinog , vol.52 , pp. 329-337
    • Nakajima, E.C.1    Van Houten, B.2
  • 19
    • 84961677958 scopus 로고    scopus 로고
    • T cells and cancer: how metabolism shapes immunity
    • Molon B, Cali B, Viola A. T cells and cancer: how metabolism shapes immunity. Front Immunol (2016) 7:20. doi:10.3389/fimmu.2016.00020
    • (2016) Front Immunol , vol.7 , pp. 20
    • Molon, B.1    Cali, B.2    Viola, A.3
  • 20
    • 84904641293 scopus 로고    scopus 로고
    • Targeting T cell immunometabolism for cancer immunotherapy; understanding the impact of the tumor microenvironment
    • Mockler MB, Conroy MJ, Lysaght J. Targeting T cell immunometabolism for cancer immunotherapy; understanding the impact of the tumor microenvironment. Front Oncol (2014) 4:107. doi:10.3389/fonc.2014.00107
    • (2014) Front Oncol , vol.4 , pp. 107
    • Mockler, M.B.1    Conroy, M.J.2    Lysaght, J.3
  • 21
    • 33646384428 scopus 로고    scopus 로고
    • Fibroblasts in cancer
    • Kalluri R, Zeisberg M. Fibroblasts in cancer. Nat Rev Cancer (2006) 6:392-401. doi:10.1038/nrc1877
    • (2006) Nat Rev Cancer , vol.6 , pp. 392-401
    • Kalluri, R.1    Zeisberg, M.2
  • 22
    • 77952568396 scopus 로고    scopus 로고
    • Hallmarks of cancer: interactions with the tumor stroma
    • Pietras K, Ostman A. Hallmarks of cancer: interactions with the tumor stroma. Exp Cell Res (2010) 316:1324-31. doi:10.1016/j.yexcr.2010.02.045
    • (2010) Exp Cell Res , vol.316 , pp. 1324-1331
    • Pietras, K.1    Ostman, A.2
  • 23
    • 24644466511 scopus 로고    scopus 로고
    • Stroma-derived three-dimensional matrices are necessary and sufficient to promote desmoplastic differentiation of normal fibroblasts
    • Amatangelo MD, Bassi DE, Klein-Szanto AJ, Cukierman E. Stroma-derived three-dimensional matrices are necessary and sufficient to promote desmoplastic differentiation of normal fibroblasts. Am J Pathol (2005) 167:475-88. doi:10.1016/S0002-9440(10)62991-4
    • (2005) Am J Pathol , vol.167 , pp. 475-488
    • Amatangelo, M.D.1    Bassi, D.E.2    Klein-Szanto, A.J.3    Cukierman, E.4
  • 24
    • 78649833819 scopus 로고    scopus 로고
    • The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by tumor-vascular disrupting agents
    • Siemann DW. The unique characteristics of tumor vasculature and preclinical evidence for its selective disruption by tumor-vascular disrupting agents. Cancer Treat Rev (2011) 37:63-74. doi:10.1016/j.ctrv.2010.05.001
    • (2011) Cancer Treat Rev , vol.37 , pp. 63-74
    • Siemann, D.W.1
  • 25
    • 62549151252 scopus 로고    scopus 로고
    • Why are tumour blood vessels abnormal and why is it important to know?
    • Nagy JA, Chang SH, Dvorak AM, Dvorak HF. Why are tumour blood vessels abnormal and why is it important to know? Br J Cancer (2009) 100:865-9. doi:10.1038/sj.bjc.6604929
    • (2009) Br J Cancer , vol.100 , pp. 865-869
    • Nagy, J.A.1    Chang, S.H.2    Dvorak, A.M.3    Dvorak, H.F.4
  • 26
    • 77953935500 scopus 로고    scopus 로고
    • Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer
    • Chiche J, Brahimi-Horn MC, Pouyssegur J. Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer. J Cell Mol Med (2010) 14:771-94. doi:10.1111/j.1582-4934.2009.00994.x
    • (2010) J Cell Mol Med , vol.14 , pp. 771-794
    • Chiche, J.1    Brahimi-Horn, M.C.2    Pouyssegur, J.3
  • 28
    • 84929353032 scopus 로고    scopus 로고
    • Molecular connections between cancer cell metabolism and the tumor microenvironment
    • Justus CR, Sanderlin EJ, Yang LV. Molecular connections between cancer cell metabolism and the tumor microenvironment. Int J Mol Sci (2015) 16:11055-86. doi:10.3390/ijms160511055
    • (2015) Int J Mol Sci , vol.16 , pp. 11055-11086
    • Justus, C.R.1    Sanderlin, E.J.2    Yang, L.V.3
  • 29
    • 58149157900 scopus 로고    scopus 로고
    • The genomic analysis of lactic acidosis and acidosis response in human cancers
    • Chen JL, Lucas JE, Schroeder T, Mori S, Wu J, Nevins J, et al. The genomic analysis of lactic acidosis and acidosis response in human cancers. PLoS Genet (2008) 4:e1000293. doi:10.1371/journal.pgen.1000293
    • (2008) PLoS Genet , vol.4
    • Chen, J.L.1    Lucas, J.E.2    Schroeder, T.3    Mori, S.4    Wu, J.5    Nevins, J.6
  • 30
    • 84900389739 scopus 로고    scopus 로고
    • Beyond Warburg effect -dual metabolic nature of cancer cells
    • Xie J, Wu H, Dai C, Pan Q, Ding Z, Hu D, et al. Beyond Warburg effect -dual metabolic nature of cancer cells. Sci Rep (2014) 4:4927. doi:10.1038/srep04927
    • (2014) Sci Rep , vol.4 , pp. 4927
    • Xie, J.1    Wu, H.2    Dai, C.3    Pan, Q.4    Ding, Z.5    Hu, D.6
  • 31
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab (2008) 7:11-20. doi:10.1016/j.cmet.2007.10.002
    • (2008) Cell Metab , vol.7 , pp. 11-20
    • DeBerardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 32
    • 0026467983 scopus 로고
    • Double role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells
    • Eigenbrodt E, Reinacher M, Scheefers-Borchel U, Scheefers H, Friis R. Double role for pyruvate kinase type M2 in the expansion of phosphometabolite pools found in tumor cells. Crit Rev Oncog (1992) 3:91-115.
    • (1992) Crit Rev Oncog , vol.3 , pp. 91-115
    • Eigenbrodt, E.1    Reinacher, M.2    Scheefers-Borchel, U.3    Scheefers, H.4    Friis, R.5
  • 33
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science (1956) 123:309-14. doi:10.1126/science.123.3191.309
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 34
  • 35
    • 84962262232 scopus 로고    scopus 로고
    • Notch stimulates growth by direct regulation of genes involved in the control of glycolysis and the tricarboxylic acid cycle
    • Slaninova V, Krafcikova M, Perez-Gomez R, Steffal P, Trantirek L, Bray SJ, et al. Notch stimulates growth by direct regulation of genes involved in the control of glycolysis and the tricarboxylic acid cycle. Open Biol (2016) 6:150155. doi:10.1098/rsob.150155
    • (2016) Open Biol , vol.6 , pp. 150155
    • Slaninova, V.1    Krafcikova, M.2    Perez-Gomez, R.3    Steffal, P.4    Trantirek, L.5    Bray, S.J.6
  • 37
    • 84949319712 scopus 로고    scopus 로고
    • Interactions between Myc and MondoA transcription factors in metabolism and tumourigenesis
    • Wilde BR, Ayer DE. Interactions between Myc and MondoA transcription factors in metabolism and tumourigenesis. Br J Cancer (2015) 113:1529-33. doi:10.1038/bjc.2015.360
    • (2015) Br J Cancer , vol.113 , pp. 1529-1533
    • Wilde, B.R.1    Ayer, D.E.2
  • 38
    • 58149136865 scopus 로고    scopus 로고
    • Roles of p53, MYC and HIF-1 in regulating glycolysis -the seventh hallmark of cancer
    • Yeung SJ, Pan J, Lee MH. Roles of p53, MYC and HIF-1 in regulating glycolysis -the seventh hallmark of cancer. Cell Mol Life Sci (2008) 65:3981-99. doi:10.1007/s00018-008-8224-x
    • (2008) Cell Mol Life Sci , vol.65 , pp. 3981-3999
    • Yeung, S.J.1    Pan, J.2    Lee, M.H.3
  • 39
    • 33751169387 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 (HIF-1)
    • Ke Q, Costa M. Hypoxia-inducible factor-1 (HIF-1). Mol Pharmacol (2006) 70:1469-80. doi:10.1124/mol.106.027029
    • (2006) Mol Pharmacol , vol.70 , pp. 1469-1480
    • Ke, Q.1    Costa, M.2
  • 40
    • 33644622570 scopus 로고    scopus 로고
    • HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
    • Papandreou I, Cairns RA, Fontana L, Lim AL, Denko NC. HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption. Cell Metab (2006) 3:187-97. doi:10.1016/j.cmet.2006.01.012
    • (2006) Cell Metab , vol.3 , pp. 187-197
    • Papandreou, I.1    Cairns, R.A.2    Fontana, L.3    Lim, A.L.4    Denko, N.C.5
  • 41
    • 33644614520 scopus 로고    scopus 로고
    • HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia
    • Kim JW, Tchernyshyov I, Semenza GL, Dang CV. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab (2006) 3:177-85. doi:10.1016/j.cmet.2006.02.002
    • (2006) Cell Metab , vol.3 , pp. 177-185
    • Kim, J.W.1    Tchernyshyov, I.2    Semenza, G.L.3    Dang, C.V.4
  • 42
    • 60549083256 scopus 로고    scopus 로고
    • Regulation of cancer cell metabolism by hypoxia-inducible factor 1
    • Semenza GL. Regulation of cancer cell metabolism by hypoxia-inducible factor 1. Semin Cancer Biol (2009) 19:12-6. doi:10.1016/j.semcancer.2008.11.009
    • (2009) Semin Cancer Biol , vol.19 , pp. 12-16
    • Semenza, G.L.1
  • 43
    • 78650308850 scopus 로고    scopus 로고
    • New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation
    • Swietach P, Hulikova A, Vaughan-Jones RD, Harris AL. New insights into the physiological role of carbonic anhydrase IX in tumour pH regulation. Oncogene (2010) 29:6509-21. doi:10.1038/onc.2010.455
    • (2010) Oncogene , vol.29 , pp. 6509-6521
    • Swietach, P.1    Hulikova, A.2    Vaughan-Jones, R.D.3    Harris, A.L.4
  • 44
    • 43649104579 scopus 로고    scopus 로고
    • Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia
    • Zhang H, Bosch-Marce M, Shimoda LA, Tan YS, Baek JH, Wesley JB, et al. Mitochondrial autophagy is an HIF-1-dependent adaptive metabolic response to hypoxia. J Biol Chem (2008) 283:10892-903. doi:10.1074/jbc.M800102200
    • (2008) J Biol Chem , vol.283 , pp. 10892-10903
    • Zhang, H.1    Bosch-Marce, M.2    Shimoda, L.A.3    Tan, Y.S.4    Baek, J.H.5    Wesley, J.B.6
  • 45
    • 33947724515 scopus 로고    scopus 로고
    • HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells
    • Fukuda R, Zhang H, Kim JW, Shimoda L, Dang CV, Semenza GL. HIF-1 regulates cytochrome oxidase subunits to optimize efficiency of respiration in hypoxic cells. Cell (2007) 129:111-22. doi:10.1016/j.cell.2007.01.047
    • (2007) Cell , vol.129 , pp. 111-122
    • Fukuda, R.1    Zhang, H.2    Kim, J.W.3    Shimoda, L.4    Dang, C.V.5    Semenza, G.L.6
  • 46
    • 34347220473 scopus 로고    scopus 로고
    • Defining the role of mTOR in cancer
    • Guertin DA, Sabatini DM. Defining the role of mTOR in cancer. Cancer Cell (2007) 12:9-22. doi:10.1016/j.ccr.2007.05.008
    • (2007) Cancer Cell , vol.12 , pp. 9-22
    • Guertin, D.A.1    Sabatini, D.M.2
  • 47
    • 1642355123 scopus 로고    scopus 로고
    • A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin
    • Browne GJ, Proud CG. A novel mTOR-regulated phosphorylation site in elongation factor 2 kinase modulates the activity of the kinase and its binding to calmodulin. Mol Cell Biol (2004) 24:2986-97. doi:10.1128/MCB.24.7.2986-2997.2004
    • (2004) Mol Cell Biol , vol.24 , pp. 2986-2997
    • Browne, G.J.1    Proud, C.G.2
  • 48
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review
    • Vaupel P, Kallinowski F, Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res (1989) 49:6449-65.
    • (1989) Cancer Res , vol.49 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 49
    • 3142587028 scopus 로고    scopus 로고
    • Tumor microenvironmental physiology and its implications for radiation oncology
    • Vaupel P. Tumor microenvironmental physiology and its implications for radiation oncology. Semin Radiat Oncol (2004) 14:198-206. doi:10.1016/j.semradonc.2004.04.008
    • (2004) Semin Radiat Oncol , vol.14 , pp. 198-206
    • Vaupel, P.1
  • 50
    • 0036554644 scopus 로고    scopus 로고
    • Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism
    • Helmlinger G, Sckell A, Dellian M, Forbes NS, Jain RK. Acid production in glycolysis-impaired tumors provides new insights into tumor metabolism. Clin Cancer Res (2002) 8:1284-91.
    • (2002) Clin Cancer Res , vol.8 , pp. 1284-1291
    • Helmlinger, G.1    Sckell, A.2    Dellian, M.3    Forbes, N.S.4    Jain, R.K.5
  • 51
    • 0033609365 scopus 로고    scopus 로고
    • An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis
    • Williams AC, Collard TJ, Paraskeva C. An acidic environment leads to p53 dependent induction of apoptosis in human adenoma and carcinoma cell lines: implications for clonal selection during colorectal carcinogenesis. Oncogene (1999) 18:3199-204. doi:10.1038/sj.onc.1202660
    • (1999) Oncogene , vol.18 , pp. 3199-3204
    • Williams, A.C.1    Collard, T.J.2    Paraskeva, C.3
  • 52
    • 0242582266 scopus 로고    scopus 로고
    • Na-H exchange-dependent increase in intracellular pH times G2/M entry and transition
    • Putney LK, Barber DL. Na-H exchange-dependent increase in intracellular pH times G2/M entry and transition. J Biol Chem (2003) 278:44645-9. doi:10.1074/jbc.M308099200
    • (2003) J Biol Chem , vol.278 , pp. 44645-44649
    • Putney, L.K.1    Barber, D.L.2
  • 53
    • 0028944778 scopus 로고
    • Low pH leads to sister-chromatid exchanges and chromosomal aberrations, and its clastogenicity is S-dependent
    • Morita T. Low pH leads to sister-chromatid exchanges and chromosomal aberrations, and its clastogenicity is S-dependent. Mutat Res (1995) 334:301-8. doi:10.1016/0165-1161(95)90067-5
    • (1995) Mutat Res , vol.334 , pp. 301-308
    • Morita, T.1
  • 54
    • 0026623304 scopus 로고
    • Clastogenicity of low pH to various cultured mammalian cells
    • Morita T, Nagaki T, Fukuda I, Okumura K. Clastogenicity of low pH to various cultured mammalian cells. Mutat Res (1992) 268:297-305. doi:10.1016/0027-5107(92)90235-T
    • (1992) Mutat Res , vol.268 , pp. 297-305
    • Morita, T.1    Nagaki, T.2    Fukuda, I.3    Okumura, K.4
  • 55
    • 54449096872 scopus 로고    scopus 로고
    • Protein kinase B/Akt phosphorylates and inhibits the cardiac Na+/H+ exchanger NHE1
    • Snabaitis AK, Cuello F, Avkiran M. Protein kinase B/Akt phosphorylates and inhibits the cardiac Na+/H+ exchanger NHE1. Circ Res (2008) 103:881-90. doi:10.1161/CIRCRESAHA.108.175877
    • (2008) Circ Res , vol.103 , pp. 881-890
    • Snabaitis, A.K.1    Cuello, F.2    Avkiran, M.3
  • 56
    • 70350389830 scopus 로고    scopus 로고
    • The sodium-hydrogen exchanger NHE1 is an Akt substrate necessary for actin filament reorganization by growth factors
    • Meima ME, Webb BA, Witkowska HE, Barber DL. The sodium-hydrogen exchanger NHE1 is an Akt substrate necessary for actin filament reorganization by growth factors. J Biol Chem (2009) 284:26666-75. doi:10.1074/jbc.M109.019448
    • (2009) J Biol Chem , vol.284 , pp. 26666-26675
    • Meima, M.E.1    Webb, B.A.2    Witkowska, H.E.3    Barber, D.L.4
  • 57
    • 84942885449 scopus 로고    scopus 로고
    • A reverse Warburg metabolism in oral squamous cell carcinoma is not dependent upon myofibroblasts
    • Jensen DH, Therkildsen MH, Dabelsteen E. A reverse Warburg metabolism in oral squamous cell carcinoma is not dependent upon myofibroblasts. J Oral Pathol Med (2015) 44:714-21. doi:10.1111/jop.12297
    • (2015) J Oral Pathol Med , vol.44 , pp. 714-721
    • Jensen, D.H.1    Therkildsen, M.H.2    Dabelsteen, E.3
  • 58
    • 84939977740 scopus 로고    scopus 로고
    • Gene and protein expression of glucose transporter 1 and glucose transporter 3 in human laryngeal cancer-the relationship with regulatory hypoxia-inducible factor-1alpha expression, tumor invasiveness, and patient prognosis
    • Starska K, Forma E, Jozwiak P, Brys M, Lewy-Trenda I, Brzezinska-Blaszczyk E, et al. Gene and protein expression of glucose transporter 1 and glucose transporter 3 in human laryngeal cancer-the relationship with regulatory hypoxia-inducible factor-1alpha expression, tumor invasiveness, and patient prognosis. Tumour Biol (2015) 36:2309-21. doi:10.1007/s13277-014-2838-4
    • (2015) Tumour Biol , vol.36 , pp. 2309-2321
    • Starska, K.1    Forma, E.2    Jozwiak, P.3    Brys, M.4    Lewy-Trenda, I.5    Brzezinska-Blaszczyk, E.6
  • 59
    • 79959688925 scopus 로고    scopus 로고
    • Coexpression of hypoxia-inducible factor-1alpha and glucose transporter-1 is associated with poor prognosis in oral squamous cell carcinoma patients
    • Eckert AW, Lautner MH, Schutze A, Taubert H, Schubert J, Bilkenroth U. Coexpression of hypoxia-inducible factor-1alpha and glucose transporter-1 is associated with poor prognosis in oral squamous cell carcinoma patients. Histopathology (2011) 58:1136-47. doi:10.1111/j.1365-2559.2011.03806.x
    • (2011) Histopathology , vol.58 , pp. 1136-1147
    • Eckert, A.W.1    Lautner, M.H.2    Schutze, A.3    Taubert, H.4    Schubert, J.5    Bilkenroth, U.6
  • 60
    • 69849087571 scopus 로고    scopus 로고
    • Targeting glucose metabolism with 2-deoxy-D-glucose for improving cancer therapy
    • Dwarakanath B, Jain V. Targeting glucose metabolism with 2-deoxy-D-glucose for improving cancer therapy. Future Oncol (2009) 5:581-5. doi:10.2217/fon.09.44
    • (2009) Future Oncol , vol.5 , pp. 581-585
    • Dwarakanath, B.1    Jain, V.2
  • 61
    • 0036717382 scopus 로고    scopus 로고
    • Molecular imaging of cancer with positron emission tomography
    • Gambhir SS. Molecular imaging of cancer with positron emission tomography. Nat Rev Cancer (2002) 2:683-93. doi:10.1038/nrc882
    • (2002) Nat Rev Cancer , vol.2 , pp. 683-693
    • Gambhir, S.S.1
  • 62
    • 33749478922 scopus 로고    scopus 로고
    • Cancer's molecular sweet tooth and the Warburg effect
    • Kim JW, Dang CV. Cancer's molecular sweet tooth and the Warburg effect. Cancer Res (2006) 66:8927-30. doi:10.1158/0008-5472.CAN-06-1501
    • (2006) Cancer Res , vol.66 , pp. 8927-8930
    • Kim, J.W.1    Dang, C.V.2
  • 63
    • 33846270366 scopus 로고    scopus 로고
    • Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia
    • Cao X, Fang L, Gibbs S, Huang Y, Dai Z, Wen P, et al. Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia. Cancer Chemother Pharmacol (2007) 59:495-505. doi:10.1007/s00280-006-0291-9
    • (2007) Cancer Chemother Pharmacol , vol.59 , pp. 495-505
    • Cao, X.1    Fang, L.2    Gibbs, S.3    Huang, Y.4    Dai, Z.5    Wen, P.6
  • 64
    • 12544256565 scopus 로고    scopus 로고
    • Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia
    • Xu RH, Pelicano H, Zhou Y, Carew JS, Feng L, Bhalla KN, et al. Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. Cancer Res (2005) 65:613-21.
    • (2005) Cancer Res , vol.65 , pp. 613-621
    • Xu, R.H.1    Pelicano, H.2    Zhou, Y.3    Carew, J.S.4    Feng, L.5    Bhalla, K.N.6
  • 65
    • 84929076785 scopus 로고    scopus 로고
    • Transient elevation of glycolysis confers radio-resistance by facilitating DNA repair in cells
    • Bhatt AN, Chauhan A, Khanna S, Rai Y, Singh S, Soni R, et al. Transient elevation of glycolysis confers radio-resistance by facilitating DNA repair in cells. BMC Cancer (2015) 15:335. doi:10.1186/s12885-015-1368-9
    • (2015) BMC Cancer , vol.15 , pp. 335
    • Bhatt, A.N.1    Chauhan, A.2    Khanna, S.3    Rai, Y.4    Singh, S.5    Soni, R.6
  • 66
    • 0034107704 scopus 로고    scopus 로고
    • Human glucose-6-phosphate dehydrogenase (G6PD) gene transforms NIH 3T3 cells and induces tumors in nude mice
    • Kuo W, Lin J, Tang TK. Human glucose-6-phosphate dehydrogenase (G6PD) gene transforms NIH 3T3 cells and induces tumors in nude mice. Int J Cancer (2000) 85:857-64. doi:10.1002/(SICI)1097-0215(20000315)85:6>857::AID-IJC20<3.3.CO;2-L
    • (2000) Int J Cancer , vol.85 , pp. 857-864
    • Kuo, W.1    Lin, J.2    Tang, T.K.3
  • 67
    • 33751569560 scopus 로고    scopus 로고
    • Pentose phosphate cycle oxidative and nonoxidative balance: a new vulnerable target for overcoming drug resistance in cancer
    • Ramos-Montoya A, Lee WN, Bassilian S, Lim S, Trebukhina RV, Kazhyna MV, et al. Pentose phosphate cycle oxidative and nonoxidative balance: a new vulnerable target for overcoming drug resistance in cancer. Int J Cancer (2006) 119:2733-41. doi:10.1002/ijc.22227
    • (2006) Int J Cancer , vol.119 , pp. 2733-2741
    • Ramos-Montoya, A.1    Lee, W.N.2    Bassilian, S.3    Lim, S.4    Trebukhina, R.V.5    Kazhyna, M.V.6
  • 68
    • 84861221308 scopus 로고    scopus 로고
    • Cyclin-dependent kinases 4 and 6 control tumor progression and direct glucose oxidation in the pentose cycle
    • Zanuy M, Ramos-Montoya A, Villacanas O, Canela N, Miranda A, Aguilar E, et al. Cyclin-dependent kinases 4 and 6 control tumor progression and direct glucose oxidation in the pentose cycle. Metabolomics (2012) 8:454-64. doi:10.1007/s11306-011-0328-x
    • (2012) Metabolomics , vol.8 , pp. 454-464
    • Zanuy, M.1    Ramos-Montoya, A.2    Villacanas, O.3    Canela, N.4    Miranda, A.5    Aguilar, E.6
  • 70
    • 84863837081 scopus 로고    scopus 로고
    • Lipid metabolism in cancer
    • Santos CR, Schulze A. Lipid metabolism in cancer. FEBS J (2012) 279:2610-23. doi:10.1111/j.1742-4658.2012.08644.x
    • (2012) FEBS J , vol.279 , pp. 2610-2623
    • Santos, C.R.1    Schulze, A.2
  • 71
    • 84883497454 scopus 로고    scopus 로고
    • Glutamine and cancer: cell biology, physiology, and clinical opportunities
    • Hensley CT, Wasti AT, DeBerardinis RJ. Glutamine and cancer: cell biology, physiology, and clinical opportunities. J Clin Invest (2013) 123:3678-84. doi:10.1172/JCI69600
    • (2013) J Clin Invest , vol.123 , pp. 3678-3684
    • Hensley, C.T.1    Wasti, A.T.2    DeBerardinis, R.J.3
  • 72
    • 84994642950 scopus 로고    scopus 로고
    • The Quid Pro Quo of the tumor/stromal interaction
    • Tajan M, Vousden KH. The Quid Pro Quo of the tumor/stromal interaction. Cell Metab (2016) 24:645-6. doi:10.1016/j.cmet.2016.10.017
    • (2016) Cell Metab , vol.24 , pp. 645-646
    • Tajan, M.1    Vousden, K.H.2
  • 73
    • 84930482603 scopus 로고    scopus 로고
    • Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development
    • Wang Q, Hardie RA, Hoy AJ, van Geldermalsen M, Gao D, Fazli L, et al. Targeting ASCT2-mediated glutamine uptake blocks prostate cancer growth and tumour development. J Pathol (2015) 236:278-89. doi:10.1002/path.4518
    • (2015) J Pathol , vol.236 , pp. 278-289
    • Wang, Q.1    Hardie, R.A.2    Hoy, A.J.3    van Geldermalsen, M.4    Gao, D.5    Fazli, L.6
  • 74
    • 84975109732 scopus 로고    scopus 로고
    • ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer
    • van Geldermalsen M, Wang Q, Nagarajah R, Marshall AD, Thoeng A, Gao D, et al. ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer. Oncogene (2016) 35:3201-8. doi:10.1038/onc.2015.381
    • (2016) Oncogene , vol.35 , pp. 3201-3208
    • van Geldermalsen, M.1    Wang, Q.2    Nagarajah, R.3    Marshall, A.D.4    Thoeng, A.5    Gao, D.6
  • 75
    • 84899715282 scopus 로고    scopus 로고
    • Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress
    • Lamonte G, Tang X, Chen JL, Wu J, Ding CK, Keenan MM, et al. Acidosis induces reprogramming of cellular metabolism to mitigate oxidative stress. Cancer Metab (2013) 1:23. doi:10.1186/2049-3002-1-23
    • (2013) Cancer Metab , vol.1 , pp. 23
    • Lamonte, G.1    Tang, X.2    Chen, J.L.3    Wu, J.4    Ding, C.K.5    Keenan, M.M.6
  • 77
    • 84993992675 scopus 로고    scopus 로고
    • Targeting amino acid metabolism in cancer growth and anti-tumor immune response
    • Ananieva E. Targeting amino acid metabolism in cancer growth and anti-tumor immune response. World J Biol Chem (2015) 6:281-9. doi:10.4331/wjbc.v6.i4.281
    • (2015) World J Biol Chem , vol.6 , pp. 281-289
    • Ananieva, E.1
  • 78
    • 84885670616 scopus 로고    scopus 로고
    • Fueling immunity: insights into metabolism and lymphocyte function
    • Pearce EL, Poffenberger MC, Chang CH, Jones RG. Fueling immunity: insights into metabolism and lymphocyte function. Science (2013) 342:1242454. doi:10.1126/science.1242454
    • (2013) Science , vol.342 , pp. 1242454
    • Pearce, E.L.1    Poffenberger, M.C.2    Chang, C.H.3    Jones, R.G.4
  • 79
    • 0027960973 scopus 로고
    • Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production
    • Greiner EF, Guppy M, Brand K. Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production. J Biol Chem (1994) 269:31484-90.
    • (1994) J Biol Chem , vol.269 , pp. 31484-31490
    • Greiner, E.F.1    Guppy, M.2    Brand, K.3
  • 80
    • 77955475969 scopus 로고    scopus 로고
    • Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation
    • Carr EL, Kelman A, Wu GS, Gopaul R, Senkevitch E, Aghvanyan A, et al. Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation. J Immunol (2010) 185:1037-44. doi:10.4049/jimmunol.0903586
    • (2010) J Immunol , vol.185 , pp. 1037-1044
    • Carr, E.L.1    Kelman, A.2    Wu, G.S.3    Gopaul, R.4    Senkevitch, E.5    Aghvanyan, A.6
  • 81
    • 84877330702 scopus 로고    scopus 로고
    • Cancer immunoediting: antigens, mechanisms, and implications to cancer immunotherapy
    • Vesely MD, Schreiber RD. Cancer immunoediting: antigens, mechanisms, and implications to cancer immunotherapy. Ann N Y Acad Sci (2013) 1284:1-5. doi:10.1111/nyas.12105
    • (2013) Ann N Y Acad Sci , vol.1284 , pp. 1-5
    • Vesely, M.D.1    Schreiber, R.D.2
  • 82
    • 84941344937 scopus 로고    scopus 로고
    • Metabolic competition in the tumor microenvironment is a driver of cancer progression
    • Chang CH, Qiu J, O'Sullivan D, Buck MD, Noguchi T, Curtis JD, et al. Metabolic competition in the tumor microenvironment is a driver of cancer progression. Cell (2015) 162:1229-41. doi:10.1016/j.cell.2015.08.016
    • (2015) Cell , vol.162 , pp. 1229-1241
    • Chang, C.H.1    Qiu, J.2    O'Sullivan, D.3    Buck, M.D.4    Noguchi, T.5    Curtis, J.D.6
  • 83
    • 84877059916 scopus 로고    scopus 로고
    • T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment
    • Crespo J, Sun H, Welling TH, Tian Z, Zou W. T cell anergy, exhaustion, senescence, and stemness in the tumor microenvironment. Curr Opin Immunol (2013) 25:214-21. doi:10.1016/j.coi.2012.12.003
    • (2013) Curr Opin Immunol , vol.25 , pp. 214-221
    • Crespo, J.1    Sun, H.2    Welling, T.H.3    Tian, Z.4    Zou, W.5
  • 84
    • 0027511220 scopus 로고
    • The role of the Crabtree effect and an endogenous fuel in the energy metabolism of resting and proliferating thymocytes
    • Guppy M, Greiner E, Brand K. The role of the Crabtree effect and an endogenous fuel in the energy metabolism of resting and proliferating thymocytes. Eur J Biochem (1993) 212:95-9. doi:10.1111/j.1432-1033.1993.tb17637.x
    • (1993) Eur J Biochem , vol.212 , pp. 95-99
    • Guppy, M.1    Greiner, E.2    Brand, K.3
  • 85
    • 84863202384 scopus 로고    scopus 로고
    • Molecular mechanisms of metabolic reprogramming in proliferating cells: implications for T-cell-mediated immunity
    • Marelli-Berg FM, Fu H, Mauro C. Molecular mechanisms of metabolic reprogramming in proliferating cells: implications for T-cell-mediated immunity. Immunology (2012) 136:363-9. doi:10.1111/j.1365-2567.2012.03583.x
    • (2012) Immunology , vol.136 , pp. 363-369
    • Marelli-Berg, F.M.1    Fu, H.2    Mauro, C.3
  • 86
    • 44449165597 scopus 로고    scopus 로고
    • Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways
    • Jacobs SR, Herman CE, Maciver NJ, Wofford JA, Wieman HL, Hammen JJ, et al. Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways. J Immunol (2008) 180:4476-86. doi:10.4049/jimmunol.180.7.4476
    • (2008) J Immunol , vol.180 , pp. 4476-4486
    • Jacobs, S.R.1    Herman, C.E.2    Maciver, N.J.3    Wofford, J.A.4    Wieman, H.L.5    Hammen, J.J.6
  • 87
    • 27744519400 scopus 로고    scopus 로고
    • Fuel feeds function: energy metabolism and the T-cell response
    • Fox CJ, Hammerman PS, Thompson CB. Fuel feeds function: energy metabolism and the T-cell response. Nat Rev Immunol (2005) 5:844-52. doi:10.1038/nri1710
    • (2005) Nat Rev Immunol , vol.5 , pp. 844-852
    • Fox, C.J.1    Hammerman, P.S.2    Thompson, C.B.3
  • 88
    • 14644444117 scopus 로고    scopus 로고
    • IL-7: maintaining T-cell memory and achieving homeostasis
    • Bradley LM, Haynes L, Swain SL. IL-7: maintaining T-cell memory and achieving homeostasis. Trends Immunol (2005) 26:172-6. doi:10.1016/j.it.2005.01.004
    • (2005) Trends Immunol , vol.26 , pp. 172-176
    • Bradley, L.M.1    Haynes, L.2    Swain, S.L.3
  • 89
    • 6344243173 scopus 로고    scopus 로고
    • Beginnings of a signal-transduction pathway for bioenergetic control of cell survival
    • Hammerman PS, Fox CJ, Thompson CB. Beginnings of a signal-transduction pathway for bioenergetic control of cell survival. Trends Biochem Sci (2004) 29:586-92. doi:10.1016/j.tibs.2004.09.008
    • (2004) Trends Biochem Sci , vol.29 , pp. 586-592
    • Hammerman, P.S.1    Fox, C.J.2    Thompson, C.B.3
  • 90
    • 0036078369 scopus 로고    scopus 로고
    • Homeostatic control of lymphocyte survival: potential origins and implications
    • Plas DR, Rathmell JC, Thompson CB. Homeostatic control of lymphocyte survival: potential origins and implications. Nat Immunol (2002) 3:515-21. doi:10.1038/ni0602-515
    • (2002) Nat Immunol , vol.3 , pp. 515-521
    • Plas, D.R.1    Rathmell, J.C.2    Thompson, C.B.3
  • 91
    • 84900440370 scopus 로고    scopus 로고
    • Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation
    • Nakaya M, Xiao Y, Zhou X, Chang JH, Chang M, Cheng X, et al. Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation. Immunity (2014) 40:692-705. doi:10.1016/j.immuni.2014.04.007
    • (2014) Immunity , vol.40 , pp. 692-705
    • Nakaya, M.1    Xiao, Y.2    Zhou, X.3    Chang, J.H.4    Chang, M.5    Cheng, X.6
  • 93
    • 33846933459 scopus 로고    scopus 로고
    • L-arginine availability regulates T-lymphocyte cell-cycle progression
    • Rodriguez PC, Quiceno DG, Ochoa AC. L-arginine availability regulates T-lymphocyte cell-cycle progression. Blood (2007) 109:1568-73. doi:10.1182/blood-2006-06-031856
    • (2007) Blood , vol.109 , pp. 1568-1573
    • Rodriguez, P.C.1    Quiceno, D.G.2    Ochoa, A.C.3
  • 94
    • 84875463042 scopus 로고    scopus 로고
    • Molecular mechanisms of T cell co-stimulation and co-inhibition
    • Chen L, Flies DB. Molecular mechanisms of T cell co-stimulation and co-inhibition. Nat Rev Immunol (2013) 13:227-42. doi:10.1038/nri3405
    • (2013) Nat Rev Immunol , vol.13 , pp. 227-242
    • Chen, L.1    Flies, D.B.2
  • 95
    • 1842581892 scopus 로고    scopus 로고
    • Regulation of T lymphocyte metabolism
    • Frauwirth KA, Thompson CB. Regulation of T lymphocyte metabolism. J Immunol (2004) 172:4661-5. doi:10.4049/jimmunol.172.8.4661
    • (2004) J Immunol , vol.172 , pp. 4661-4665
    • Frauwirth, K.A.1    Thompson, C.B.2
  • 96
    • 84906971768 scopus 로고    scopus 로고
    • Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by IkappaB kinase alpha (IKKalpha)
    • Dan HC, Ebbs A, Pasparakis M, Van Dyke T, Basseres DS, Baldwin AS. Akt-dependent activation of mTORC1 complex involves phosphorylation of mTOR (mammalian target of rapamycin) by IkappaB kinase alpha (IKKalpha). J Biol Chem (2014) 289:25227-40. doi:10.1074/jbc.M114.554881
    • (2014) J Biol Chem , vol.289 , pp. 25227-25240
    • Dan, H.C.1    Ebbs, A.2    Pasparakis, M.3    Van Dyke, T.4    Basseres, D.S.5    Baldwin, A.S.6
  • 97
    • 84923321725 scopus 로고    scopus 로고
    • mTOR coordinates protein synthesis, mitochondrial activity and proliferation
    • Morita M, Gravel SP, Hulea L, Larsson O, Pollak M, St-Pierre J, et al. mTOR coordinates protein synthesis, mitochondrial activity and proliferation. Cell Cycle (2015) 14:473-80. doi:10.4161/15384101.2014.991572
    • (2015) Cell Cycle , vol.14 , pp. 473-480
    • Morita, M.1    Gravel, S.P.2    Hulea, L.3    Larsson, O.4    Pollak, M.5    St-Pierre, J.6
  • 98
    • 84255199079 scopus 로고    scopus 로고
    • The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
    • Wang R, Dillon CP, Shi LZ, Milasta S, Carter R, Finkelstein D, et al. The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity (2011) 35:871-82. doi:10.1016/j.immuni.2011.09.021
    • (2011) Immunity , vol.35 , pp. 871-882
    • Wang, R.1    Dillon, C.P.2    Shi, L.Z.3    Milasta, S.4    Carter, R.5    Finkelstein, D.6
  • 99
    • 78049287331 scopus 로고    scopus 로고
    • mTOR signalling and metabolic regulation of T cell differentiation
    • Peter C, Waldmann H, Cobbold SP. mTOR signalling and metabolic regulation of T cell differentiation. Curr Opin Immunol (2010) 22:655-61. doi:10.1016/j.coi.2010.08.010
    • (2010) Curr Opin Immunol , vol.22 , pp. 655-661
    • Peter, C.1    Waldmann, H.2    Cobbold, S.P.3
  • 100
    • 77957054466 scopus 로고    scopus 로고
    • The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism
    • Powell JD, Delgoffe GM. The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism. Immunity (2010) 33:301-11. doi:10.1016/j.immuni.2010.09.002
    • (2010) Immunity , vol.33 , pp. 301-311
    • Powell, J.D.1    Delgoffe, G.M.2
  • 101
    • 79953172571 scopus 로고    scopus 로고
    • Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets
    • Michalek RD, Gerriets VA, Jacobs SR, Macintyre AN, MacIver NJ, Mason EF, et al. Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J Immunol (2011) 186:3299-303. doi:10.4049/jimmunol.1003613
    • (2011) J Immunol , vol.186 , pp. 3299-3303
    • Michalek, R.D.1    Gerriets, V.A.2    Jacobs, S.R.3    Macintyre, A.N.4    MacIver, N.J.5    Mason, E.F.6
  • 102
    • 77957371028 scopus 로고    scopus 로고
    • Stability of the regulatory T cell lineage in vivo
    • Rubtsov YP, Niec RE, Josefowicz S, Li L, Darce J, Mathis D, et al. Stability of the regulatory T cell lineage in vivo. Science (2010) 329:1667-71. doi:10.1126/science.1191996
    • (2010) Science , vol.329 , pp. 1667-1671
    • Rubtsov, Y.P.1    Niec, R.E.2    Josefowicz, S.3    Li, L.4    Darce, J.5    Mathis, D.6
  • 103
    • 84856183120 scopus 로고    scopus 로고
    • Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development
    • van der Windt GJ, Everts B, Chang CH, Curtis JD, Freitas TC, Amiel E, et al. Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. Immunity (2012) 36:68-78. doi:10.1016/j.immuni.2011.12.007
    • (2012) Immunity , vol.36 , pp. 68-78
    • van der Windt, G.J.1    Everts, B.2    Chang, C.H.3    Curtis, J.D.4    Freitas, T.C.5    Amiel, E.6
  • 104
    • 79961088512 scopus 로고    scopus 로고
    • Organ engineering based on decellularized matrix scaffolds
    • Song JJ, Ott HC. Organ engineering based on decellularized matrix scaffolds. Trends Mol Med (2011) 17:424-32. doi:10.1016/j.molmed.2011.03.005
    • (2011) Trends Mol Med , vol.17 , pp. 424-432
    • Song, J.J.1    Ott, H.C.2
  • 106
    • 70350683363 scopus 로고    scopus 로고
    • The tumor microenvironment: the making of a paradigm
    • Witz IP. The tumor microenvironment: the making of a paradigm. Cancer Microenviron (2009) 2(Suppl 1):9-17. doi:10.1007/s12307-009-0025-8
    • (2009) Cancer Microenviron , vol.2 , pp. 9-17
    • Witz, I.P.1
  • 108
    • 84955204530 scopus 로고    scopus 로고
    • Stroma as an active player in the development of the tumor microenvironment
    • Vannucci L. Stroma as an active player in the development of the tumor microenvironment. Cancer Microenviron (2015) 8:159-66. doi:10.1007/s12307-014-0150-x
    • (2015) Cancer Microenviron , vol.8 , pp. 159-166
    • Vannucci, L.1
  • 109
    • 84995755029 scopus 로고    scopus 로고
    • Intratumor stromal proportion predicts aggressive phenotype of gastric signet ring cell carcinomas
    • Lee D, Ham IH, Son SY, Han SU, Kim YB, Hur H. Intratumor stromal proportion predicts aggressive phenotype of gastric signet ring cell carcinomas. Gastric Cancer (2016) 1-11. doi:10.1007/s10120-016-0669-2
    • (2016) Gastric Cancer , pp. 1-11
    • Lee, D.1    Ham, I.H.2    Son, S.Y.3    Han, S.U.4    Kim, Y.B.5    Hur, H.6
  • 110
    • 84897544161 scopus 로고    scopus 로고
    • Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth
    • Martinez-Outschoorn UE, Lisanti MP, Sotgia F. Catabolic cancer-associated fibroblasts transfer energy and biomass to anabolic cancer cells, fueling tumor growth. Semin Cancer Biol (2014) 25:47-60. doi:10.1016/j.semcancer.2014.01.005
    • (2014) Semin Cancer Biol , vol.25 , pp. 47-60
    • Martinez-Outschoorn, U.E.1    Lisanti, M.P.2    Sotgia, F.3
  • 111
    • 84867112200 scopus 로고    scopus 로고
    • Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay
    • Fiaschi T, Marini A, Giannoni E, Taddei ML, Gandellini P, De Donatis A, et al. Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumor-stroma interplay. Cancer Res (2012) 72:5130-40. doi:10.1158/0008-5472.CAN-12-1949
    • (2012) Cancer Res , vol.72 , pp. 5130-5140
    • Fiaschi, T.1    Marini, A.2    Giannoni, E.3    Taddei, M.L.4    Gandellini, P.5    De Donatis, A.6
  • 112
    • 84907487722 scopus 로고    scopus 로고
    • Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells
    • Bonuccelli G, Avnet S, Grisendi G, Salerno M, Granchi D, Dominici M, et al. Role of mesenchymal stem cells in osteosarcoma and metabolic reprogramming of tumor cells. Oncotarget (2014) 5:7575-88. doi:10.18632/oncotarget.2243
    • (2014) Oncotarget , vol.5 , pp. 7575-7588
    • Bonuccelli, G.1    Avnet, S.2    Grisendi, G.3    Salerno, M.4    Granchi, D.5    Dominici, M.6
  • 113
    • 79957922046 scopus 로고    scopus 로고
    • Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts
    • Whitaker-Menezes D, Martinez-Outschoorn UE, Lin Z, Ertel A, Flomenberg N, Witkiewicz AK, et al. Evidence for a stromal-epithelial "lactate shuttle" in human tumors: MCT4 is a marker of oxidative stress in cancer-associated fibroblasts. Cell Cycle (2011) 10:1772-83. doi:10.4161/cc.10.11.15659
    • (2011) Cell Cycle , vol.10 , pp. 1772-1783
    • Whitaker-Menezes, D.1    Martinez-Outschoorn, U.E.2    Lin, Z.3    Ertel, A.4    Flomenberg, N.5    Witkiewicz, A.K.6
  • 114
    • 84944916889 scopus 로고    scopus 로고
    • Overexpression of monocarboxylate anion transporter 1 and 4 in T24-induced cancer-associated fibroblasts regulates the progression of bladder cancer cells in a 3D microfluidic device
    • Shi H, Jiang H, Wang L, Cao Y, Liu P, Xu X, et al. Overexpression of monocarboxylate anion transporter 1 and 4 in T24-induced cancer-associated fibroblasts regulates the progression of bladder cancer cells in a 3D microfluidic device. Cell Cycle (2015) 14:3058-65. doi:10.1080/15384101.2015.1053666
    • (2015) Cell Cycle , vol.14 , pp. 3058-3065
    • Shi, H.1    Jiang, H.2    Wang, L.3    Cao, Y.4    Liu, P.5    Xu, X.6
  • 115
    • 84961642247 scopus 로고    scopus 로고
    • Lactic acid polarizes macrophages to a tumor-promoting state
    • Colegio OR. Lactic acid polarizes macrophages to a tumor-promoting state. Oncoimmunology (2016) 5:e1014774. doi:10.1080/2162402X.2015.1014774
    • (2016) Oncoimmunology , vol.5
    • Colegio, O.R.1
  • 116
    • 84907223092 scopus 로고    scopus 로고
    • Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
    • Colegio OR, Chu NQ, Szabo AL, Chu T, Rhebergen AM, Jairam V, et al. Functional polarization of tumour-associated macrophages by tumour-derived lactic acid. Nature (2014) 513:559-63. doi:10.1038/nature13490
    • (2014) Nature , vol.513 , pp. 559-563
    • Colegio, O.R.1    Chu, N.Q.2    Szabo, A.L.3    Chu, T.4    Rhebergen, A.M.5    Jairam, V.6
  • 117
    • 77953268611 scopus 로고    scopus 로고
    • Alternative activation of macrophages: mechanism and functions
    • Gordon S, Martinez FO. Alternative activation of macrophages: mechanism and functions. Immunity (2010) 32:593-604. doi:10.1016/j.immuni.2010.05.007
    • (2010) Immunity , vol.32 , pp. 593-604
    • Gordon, S.1    Martinez, F.O.2
  • 118
    • 85013068210 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition induction is associated with augmented glucose uptake and lactate production in pancreatic ductal adenocarcinoma
    • Liu M, Quek LE, Sultani G, Turner N. Epithelial-mesenchymal transition induction is associated with augmented glucose uptake and lactate production in pancreatic ductal adenocarcinoma. Cancer Metab (2016) 4:19. doi:10.1186/s40170-016-0160-x
    • (2016) Cancer Metab , vol.4 , pp. 19
    • Liu, M.1    Quek, L.E.2    Sultani, G.3    Turner, N.4
  • 119
    • 85069238583 scopus 로고    scopus 로고
    • Endothelial cell metabolism: parallels and divergences with cancer cell metabolism
    • Verdegem D, Moens S, Stapor P, Carmeliet P. Endothelial cell metabolism: parallels and divergences with cancer cell metabolism. Cancer Metab (2014) 2:19. doi:10.1186/2049-3002-2-19
    • (2014) Cancer Metab , vol.2 , pp. 19
    • Verdegem, D.1    Moens, S.2    Stapor, P.3    Carmeliet, P.4
  • 120
    • 84923164098 scopus 로고    scopus 로고
    • Molecular pathways: trafficking of metabolic resources in the tumor microenvironment
    • Romero IL, Mukherjee A, Kenny HA, Litchfield LM, Lengyel E. Molecular pathways: trafficking of metabolic resources in the tumor microenvironment. Clin Cancer Res (2015) 21:680-6. doi:10.1158/1078-0432.CCR-14-2198
    • (2015) Clin Cancer Res , vol.21 , pp. 680-686
    • Romero, I.L.1    Mukherjee, A.2    Kenny, H.A.3    Litchfield, L.M.4    Lengyel, E.5
  • 121
    • 84885657687 scopus 로고    scopus 로고
    • Section 30.2, each organ has a unique metabolic profile. In: Freeman WH, editor. Biochemistry
    • 5th edn. New York: WH Freeman and Company
    • Berg JM, Tymoczko JL, Stryer L. Section 30.2, each organ has a unique metabolic profile. In: Freeman WH, editor. Biochemistry, 5th edn. New York: WH Freeman and Company (2002). Available from: https://www.ncbi.nlm.nih.gov/books/NBK22436/
    • (2002)
    • Berg, J.M.1    Tymoczko, J.L.2    Stryer, L.3
  • 122
    • 84858590826 scopus 로고    scopus 로고
    • Accessories to the crime: functions of cells recruited to the tumor microenvironment
    • Hanahan D, Coussens LM. Accessories to the crime: functions of cells recruited to the tumor microenvironment. Cancer Cell (2012) 21:309-22. doi:10.1016/j.ccr.2012.02.022
    • (2012) Cancer Cell , vol.21 , pp. 309-322
    • Hanahan, D.1    Coussens, L.M.2
  • 123
    • 84941366350 scopus 로고    scopus 로고
    • Phosphoenolpyruvate is a metabolic checkpoint of anti-tumor T cell responses
    • Ho PC, Bihuniak JD, Macintyre AN, Staron M, Liu X, Amezquita R, et al. Phosphoenolpyruvate is a metabolic checkpoint of anti-tumor T cell responses. Cell (2015) 162:1217-28. doi:10.1016/j.cell.2015.08.012
    • (2015) Cell , vol.162 , pp. 1217-1228
    • Ho, P.C.1    Bihuniak, J.D.2    Macintyre, A.N.3    Staron, M.4    Liu, X.5    Amezquita, R.6
  • 124
    • 84935026613 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts provide a suitable microenvironment for tumor development and progression in oral tongue squamous cancer
    • Li H, Zhang J, Chen SW, Liu LL, Li L, Gao F, et al. Cancer-associated fibroblasts provide a suitable microenvironment for tumor development and progression in oral tongue squamous cancer. J Transl Med (2015) 13:198. doi:10.1186/s12967-015-0551-8
    • (2015) J Transl Med , vol.13 , pp. 198
    • Li, H.1    Zhang, J.2    Chen, S.W.3    Liu, L.L.4    Li, L.5    Gao, F.6
  • 125
    • 84988624490 scopus 로고    scopus 로고
    • Bidirectional cross talk between patient-derived melanoma and cancer-associated fibroblasts promotes invasion and proliferation
    • Izar B, Joyce CE, Goff S, Cho NL, Shah PM, Sharma G, et al. Bidirectional cross talk between patient-derived melanoma and cancer-associated fibroblasts promotes invasion and proliferation. Pigment Cell Melanoma Res (2016) 29:656-68. doi:10.1111/pcmr.12513
    • (2016) Pigment Cell Melanoma Res , vol.29 , pp. 656-668
    • Izar, B.1    Joyce, C.E.2    Goff, S.3    Cho, N.L.4    Shah, P.M.5    Sharma, G.6
  • 126
    • 0033215242 scopus 로고    scopus 로고
    • Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium
    • Olumi AF, Grossfeld GD, Hayward SW, Carroll PR, Tlsty TD, Cunha GR. Carcinoma-associated fibroblasts direct tumor progression of initiated human prostatic epithelium. Cancer Res (1999) 59:5002-11.
    • (1999) Cancer Res , vol.59 , pp. 5002-5011
    • Olumi, A.F.1    Grossfeld, G.D.2    Hayward, S.W.3    Carroll, P.R.4    Tlsty, T.D.5    Cunha, G.R.6
  • 127
    • 84978695867 scopus 로고    scopus 로고
    • The ever-expanding role of HIF in tumour and stromal biology
    • LaGory EL, Giaccia AJ. The ever-expanding role of HIF in tumour and stromal biology. Nat Cell Biol (2016) 18:356-65. doi:10.1038/ncb3330
    • (2016) Nat Cell Biol , vol.18 , pp. 356-365
    • LaGory, E.L.1    Giaccia, A.J.2
  • 128
    • 78149409458 scopus 로고    scopus 로고
    • Hypoxia-inducible factors as essential regulators of inflammation
    • Imtiyaz HZ, Simon MC. Hypoxia-inducible factors as essential regulators of inflammation. Curr Top Microbiol Immunol (2010) 345:105-20. doi:10.1007/82_2010_74
    • (2010) Curr Top Microbiol Immunol , vol.345 , pp. 105-120
    • Imtiyaz, H.Z.1    Simon, M.C.2
  • 129
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer (2003) 3:721-32. doi:10.1038/nrc1187
    • (2003) Nat Rev Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 130
    • 57149142495 scopus 로고    scopus 로고
    • The impact of O2 availability on human cancer
    • Bertout JA, Patel SA, Simon MC. The impact of O2 availability on human cancer. Nat Rev Cancer (2008) 8:967-75. doi:10.1038/nrc2540
    • (2008) Nat Rev Cancer , vol.8 , pp. 967-975
    • Bertout, J.A.1    Patel, S.A.2    Simon, M.C.3
  • 131
    • 84867381718 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
    • Clambey ET, McNamee EN, Westrich JA, Glover LE, Campbell EL, Jedlicka P, et al. Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc Natl Acad Sci U S A (2012) 109:E2784-93. doi:10.1073/pnas.1202366109
    • (2012) Proc Natl Acad Sci U S A , vol.109 , pp. E2784-E2793
    • Clambey, E.T.1    McNamee, E.N.2    Westrich, J.A.3    Glover, L.E.4    Campbell, E.L.5    Jedlicka, P.6
  • 132
    • 80052277906 scopus 로고    scopus 로고
    • Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1
    • Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y, et al. Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell (2011) 146:772-84. doi:10.1016/j.cell.2011.07.033
    • (2011) Cell , vol.146 , pp. 772-784
    • Dang, E.V.1    Barbi, J.2    Yang, H.Y.3    Jinasena, D.4    Yu, H.5    Zheng, Y.6
  • 133
    • 55249095393 scopus 로고    scopus 로고
    • Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1alpha
    • Ben-Shoshan J, Maysel-Auslender S, Mor A, Keren G, George J. Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1alpha. Eur J Immunol (2008) 38:2412-8. doi:10.1002/eji.200838318
    • (2008) Eur J Immunol , vol.38 , pp. 2412-2418
    • Ben-Shoshan, J.1    Maysel-Auslender, S.2    Mor, A.3    Keren, G.4    George, J.5
  • 134
    • 79960369458 scopus 로고    scopus 로고
    • HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
    • Shi LZ, Wang R, Huang G, Vogel P, Neale G, Green DR, et al. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J Exp Med (2011) 208:1367-76. doi:10.1084/jem.20110278
    • (2011) J Exp Med , vol.208 , pp. 1367-1376
    • Shi, L.Z.1    Wang, R.2    Huang, G.3    Vogel, P.4    Neale, G.5    Green, D.R.6
  • 135
    • 84892747845 scopus 로고    scopus 로고
    • Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population
    • Laoui D, Van Overmeire E, Di Conza G, Aldeni C, Keirsse J, Morias Y, et al. Tumor hypoxia does not drive differentiation of tumor-associated macrophages but rather fine-tunes the M2-like macrophage population. Cancer Res (2014) 74:24-30. doi:10.1158/0008-5472.CAN-13-1196
    • (2014) Cancer Res , vol.74 , pp. 24-30
    • Laoui, D.1    Van Overmeire, E.2    Di Conza, G.3    Aldeni, C.4    Keirsse, J.5    Morias, Y.6
  • 136
    • 57649112725 scopus 로고    scopus 로고
    • Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis
    • Stockmann C, Doedens A, Weidemann A, Zhang N, Takeda N, Greenberg JI, et al. Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis. Nature (2008) 456:814-8. doi:10.1038/nature07445
    • (2008) Nature , vol.456 , pp. 814-818
    • Stockmann, C.1    Doedens, A.2    Weidemann, A.3    Zhang, N.4    Takeda, N.5    Greenberg, J.I.6
  • 137
    • 84994591173 scopus 로고    scopus 로고
    • Macrophage metabolism controls tumor blood vessel morphogenesis and metastasis
    • Wenes M, Shang M, Di Matteo M, Goveia J, Martin-Perez R, Serneels J, et al. Macrophage metabolism controls tumor blood vessel morphogenesis and metastasis. Cell Metab (2016) 24:701-15. doi:10.1016/j.cmet.2016.09.008
    • (2016) Cell Metab , vol.24 , pp. 701-715
    • Wenes, M.1    Shang, M.2    Di Matteo, M.3    Goveia, J.4    Martin-Perez, R.5    Serneels, J.6
  • 138
    • 84919452312 scopus 로고    scopus 로고
    • Metabolic reprograming in macrophage polarization
    • Galvan-Pena S, O'Neill LA. Metabolic reprograming in macrophage polarization. Front Immunol (2014) 5:420. doi:10.3389/fimmu.2014.00420
    • (2014) Front Immunol , vol.5 , pp. 420
    • Galvan-Pena, S.1    O'Neill, L.A.2
  • 139
    • 84892832431 scopus 로고    scopus 로고
    • Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo
    • Jetten N, Verbruggen S, Gijbels MJ, Post MJ, De Winther MP, Donners MM. Anti-inflammatory M2, but not pro-inflammatory M1 macrophages promote angiogenesis in vivo. Angiogenesis (2014) 17:109-18. doi:10.1007/s10456-013-9381-6
    • (2014) Angiogenesis , vol.17 , pp. 109-118
    • Jetten, N.1    Verbruggen, S.2    Gijbels, M.J.3    Post, M.J.4    De Winther, M.P.5    Donners, M.M.6
  • 140
    • 84875866913 scopus 로고    scopus 로고
    • M2 macrophage polarisation is associated with alveolar formation during postnatal lung development
    • Jones CV, Williams TM, Walker KA, Dickinson H, Sakkal S, Rumballe BA, et al. M2 macrophage polarisation is associated with alveolar formation during postnatal lung development. Respir Res (2013) 14:41. doi:10.1186/1465-9921-14-41
    • (2013) Respir Res , vol.14 , pp. 41
    • Jones, C.V.1    Williams, T.M.2    Walker, K.A.3    Dickinson, H.4    Sakkal, S.5    Rumballe, B.A.6
  • 141
    • 84874693196 scopus 로고    scopus 로고
    • The tumor microenvironment at a glance
    • Balkwill FR, Capasso M, Hagemann T. The tumor microenvironment at a glance. J Cell Sci (2012) 125:5591-6. doi:10.1242/jcs.116392
    • (2012) J Cell Sci , vol.125 , pp. 5591-5596
    • Balkwill, F.R.1    Capasso, M.2    Hagemann, T.3
  • 142
    • 84944931173 scopus 로고    scopus 로고
    • Apoptosis of tumor infiltrating effector TIM-3+CD8+ T cells in colon cancer
    • Kang CW, Dutta A, Chang LY, Mahalingam J, Lin YC, Chiang JM, et al. Apoptosis of tumor infiltrating effector TIM-3+CD8+ T cells in colon cancer. Sci Rep (2015) 5:15659. doi:10.1038/srep15659
    • (2015) Sci Rep , vol.5 , pp. 15659
    • Kang, C.W.1    Dutta, A.2    Chang, L.Y.3    Mahalingam, J.4    Lin, Y.C.5    Chiang, J.M.6
  • 143
    • 84979609119 scopus 로고    scopus 로고
    • Galectin-9 modulates immunity by promoting Th2/M2 differentiation and impacts survival in patients with metastatic melanoma
    • Enninga EA, Nevala WK, Holtan SG, Leontovich AA, Markovic SN. Galectin-9 modulates immunity by promoting Th2/M2 differentiation and impacts survival in patients with metastatic melanoma. Melanoma Res (2016) 26:429-41. doi:10.1097/CMR.0000000000000281
    • (2016) Melanoma Res , vol.26 , pp. 429-441
    • Enninga, E.A.1    Nevala, W.K.2    Holtan, S.G.3    Leontovich, A.A.4    Markovic, S.N.5
  • 144
    • 69949120571 scopus 로고    scopus 로고
    • A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses
    • Wu S, Rhee KJ, Albesiano E, Rabizadeh S, Wu X, Yen HR, et al. A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses. Nat Med (2009) 15:1016-22. doi:10.1038/nm.2015
    • (2009) Nat Med , vol.15 , pp. 1016-1022
    • Wu, S.1    Rhee, K.J.2    Albesiano, E.3    Rabizadeh, S.4    Wu, X.5    Yen, H.R.6
  • 145
    • 84992735180 scopus 로고    scopus 로고
    • Local and systemic Th17 immune response associated with advanced stage colon cancer
    • Sharp SP, Avram D, Stain SC, Lee EC. Local and systemic Th17 immune response associated with advanced stage colon cancer. J Surg Res (2017) 208:180-6. doi:10.1016/j.jss.2016.09.038
    • (2017) J Surg Res , vol.208 , pp. 180-186
    • Sharp, S.P.1    Avram, D.2    Stain, S.C.3    Lee, E.C.4
  • 146
    • 84906568277 scopus 로고    scopus 로고
    • Th17 cells and interleukin-17 increase with poor prognosis in patients with acute myeloid leukemia
    • Han Y, Ye A, Bi L, Wu J, Yu K, Zhang S. Th17 cells and interleukin-17 increase with poor prognosis in patients with acute myeloid leukemia. Cancer Sci (2014) 105:933-42. doi:10.1111/cas.12459
    • (2014) Cancer Sci , vol.105 , pp. 933-942
    • Han, Y.1    Ye, A.2    Bi, L.3    Wu, J.4    Yu, K.5    Zhang, S.6
  • 147
    • 0037423948 scopus 로고    scopus 로고
    • HIF-1alpha is essential for myeloid cell-mediated inflammation
    • Cramer T, Yamanishi Y, Clausen BE, Forster I, Pawlinski R, Mackman N, et al. HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell (2003) 112:645-57. doi:10.1016/S0092-8674(03)00154-5
    • (2003) Cell , vol.112 , pp. 645-657
    • Cramer, T.1    Yamanishi, Y.2    Clausen, B.E.3    Forster, I.4    Pawlinski, R.5    Mackman, N.6
  • 148
    • 78149330949 scopus 로고    scopus 로고
    • HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
    • Corzo CA, Condamine T, Lu L, Cotter MJ, Youn JI, Cheng P, et al. HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J Exp Med (2010) 207:2439-53. doi:10.1084/jem.20100587
    • (2010) J Exp Med , vol.207 , pp. 2439-2453
    • Corzo, C.A.1    Condamine, T.2    Lu, L.3    Cotter, M.J.4    Youn, J.I.5    Cheng, P.6
  • 149
    • 20444490000 scopus 로고    scopus 로고
    • Spatial heterogeneity and oxygen dependence of glucose consumption in R3230Ac and fibrosarcomas of the Fischer 344 rat
    • Schroeder T, Yuan H, Viglianti BL, Peltz C, Asopa S, Vujaskovic Z, et al. Spatial heterogeneity and oxygen dependence of glucose consumption in R3230Ac and fibrosarcomas of the Fischer 344 rat. Cancer Res (2005) 65:5163-71. doi:10.1158/0008-5472.CAN-04-3900
    • (2005) Cancer Res , vol.65 , pp. 5163-5171
    • Schroeder, T.1    Yuan, H.2    Viglianti, B.L.3    Peltz, C.4    Asopa, S.5    Vujaskovic, Z.6
  • 150
    • 84875494365 scopus 로고    scopus 로고
    • Metabolic regulation of T lymphocytes
    • MacIver NJ, Michalek RD, Rathmell JC. Metabolic regulation of T lymphocytes. Annu Rev Immunol (2013) 31:259-83. doi:10.1146/annurev-immunol-032712-095956
    • (2013) Annu Rev Immunol , vol.31 , pp. 259-283
    • MacIver, N.J.1    Michalek, R.D.2    Rathmell, J.C.3
  • 151
    • 55249114228 scopus 로고    scopus 로고
    • Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells
    • Cham CM, Driessens G, O'Keefe JP, Gajewski TF. Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells. Eur J Immunol (2008) 38:2438-50. doi:10.1002/eji.200838289
    • (2008) Eur J Immunol , vol.38 , pp. 2438-2450
    • Cham, C.M.1    Driessens, G.2    O'Keefe, J.P.3    Gajewski, T.F.4
  • 153
    • 84878831880 scopus 로고    scopus 로고
    • Posttranscriptional control of T cell effector function by aerobic glycolysis
    • Chang CH, Curtis JD, Maggi LB Jr, Faubert B, Villarino AV, O'Sullivan D, et al. Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell (2013) 153:1239-51. doi:10.1016/j.cell.2013.05.016
    • (2013) Cell , vol.153 , pp. 1239-1251
    • Chang, C.H.1    Curtis, J.D.2    Maggi, L.B.3    Faubert, B.4    Villarino, A.V.5    O'Sullivan, D.6
  • 154
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: the next generation. Cell (2011) 144:646-74. doi:10.1016/j.cell.2011.02.013
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 155
    • 0036515618 scopus 로고    scopus 로고
    • Cell metabolism in the regulation of programmed cell death
    • Plas DR, Thompson CB. Cell metabolism in the regulation of programmed cell death. Trends Endocrinol Metab (2002) 13:75-8. doi:10.1016/S1043-2760(01)00528-8
    • (2002) Trends Endocrinol Metab , vol.13 , pp. 75-78
    • Plas, D.R.1    Thompson, C.B.2
  • 156
    • 0036716281 scopus 로고    scopus 로고
    • The Bcl2 family: regulators of the cellular life-or-death switch
    • Cory S, Adams JM. The Bcl2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer (2002) 2:647-56. doi:10.1038/nrc883
    • (2002) Nat Rev Cancer , vol.2 , pp. 647-656
    • Cory, S.1    Adams, J.M.2
  • 157
    • 84997766028 scopus 로고    scopus 로고
    • The tumor microenvironment represses T cell mitochondrial biogenesis to drive intratumoral T cell metabolic insufficiency and dysfunction
    • Scharping NE, Menk AV, Moreci RS, Whetstone RD, Dadey RE, Watkins SC, et al. The tumor microenvironment represses T cell mitochondrial biogenesis to drive intratumoral T cell metabolic insufficiency and dysfunction. Immunity (2016) 45:374-88. doi:10.1016/j.immuni.2016.07.009
    • (2016) Immunity , vol.45 , pp. 374-388
    • Scharping, N.E.1    Menk, A.V.2    Moreci, R.S.3    Whetstone, R.D.4    Dadey, R.E.5    Watkins, S.C.6
  • 158
    • 84883513587 scopus 로고    scopus 로고
    • Oncometabolites: linking altered metabolism with cancer
    • Yang M, Soga T, Pollard PJ. Oncometabolites: linking altered metabolism with cancer. J Clin Invest (2013) 123:3652-8. doi:10.1172/JCI67228
    • (2013) J Clin Invest , vol.123 , pp. 3652-3658
    • Yang, M.1    Soga, T.2    Pollard, P.J.3
  • 159
    • 34247352844 scopus 로고    scopus 로고
    • Inhibitory effect of tumor cell-derived lactic acid on human T cells
    • Fischer K, Hoffmann P, Voelkl S, Meidenbauer N, Ammer J, Edinger M, et al. Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood (2007) 109:3812-9. doi:10.1182/blood-2006-07-035972
    • (2007) Blood , vol.109 , pp. 3812-3819
    • Fischer, K.1    Hoffmann, P.2    Voelkl, S.3    Meidenbauer, N.4    Ammer, J.5    Edinger, M.6
  • 160
    • 0035881307 scopus 로고    scopus 로고
    • Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo
    • Fukumura D, Xu L, Chen Y, Gohongi T, Seed B, Jain RK. Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo. Cancer Res (2001) 61:6020-4.
    • (2001) Cancer Res , vol.61 , pp. 6020-6024
    • Fukumura, D.1    Xu, L.2    Chen, Y.3    Gohongi, T.4    Seed, B.5    Jain, R.K.6
  • 161
    • 84861861104 scopus 로고    scopus 로고
    • Modulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes
    • Calcinotto A, Filipazzi P, Grioni M, Iero M, De Milito A, Ricupito A, et al. Modulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes. Cancer Res (2012) 72:2746-56. doi:10.1158/0008-5472.CAN-11-1272
    • (2012) Cancer Res , vol.72 , pp. 2746-2756
    • Calcinotto, A.1    Filipazzi, P.2    Grioni, M.3    Iero, M.4    De Milito, A.5    Ricupito, A.6
  • 162
    • 84879203221 scopus 로고    scopus 로고
    • Dichloroacetate improves immune dysfunction caused by tumor-secreted lactic acid and increases antitumor immunoreactivity
    • Ohashi T, Akazawa T, Aoki M, Kuze B, Mizuta K, Ito Y, et al. Dichloroacetate improves immune dysfunction caused by tumor-secreted lactic acid and increases antitumor immunoreactivity. Int J Cancer (2013) 133:1107-18. doi:10.1002/ijc.28114
    • (2013) Int J Cancer , vol.133 , pp. 1107-1118
    • Ohashi, T.1    Akazawa, T.2    Aoki, M.3    Kuze, B.4    Mizuta, K.5    Ito, Y.6
  • 164
    • 30744448647 scopus 로고    scopus 로고
    • Extracellular acidosis induces neutrophil activation by a mechanism dependent on activation of phosphatidylinositol 3-kinase/Akt and ERK pathways
    • Martinez D, Vermeulen M, Trevani A, Ceballos A, Sabatte J, Gamberale R, et al. Extracellular acidosis induces neutrophil activation by a mechanism dependent on activation of phosphatidylinositol 3-kinase/Akt and ERK pathways. J Immunol (2006) 176:1163-71. doi:10.4049/jimmunol.176.2.1163
    • (2006) J Immunol , vol.176 , pp. 1163-1171
    • Martinez, D.1    Vermeulen, M.2    Trevani, A.3    Ceballos, A.4    Sabatte, J.5    Gamberale, R.6
  • 165
    • 0033848896 scopus 로고    scopus 로고
    • Acidic pH inhibits non-MHC-restricted killer cell functions
    • Fischer B, Muller B, Fischer KG, Baur N, Kreutz W. Acidic pH inhibits non-MHC-restricted killer cell functions. Clin Immunol (2000) 96:252-63. doi:10.1006/clim.2000.4904
    • (2000) Clin Immunol , vol.96 , pp. 252-263
    • Fischer, B.1    Muller, B.2    Fischer, K.G.3    Baur, N.4    Kreutz, W.5
  • 166
    • 0034094734 scopus 로고    scopus 로고
    • An acidic microenvironment impairs the generation of non-major histocompatibility complex-restricted killer cells
    • Muller B, Fischer B, Kreutz W. An acidic microenvironment impairs the generation of non-major histocompatibility complex-restricted killer cells. Immunology (2000) 99:375-84. doi:10.1046/j.1365-2567.2000.00975.x
    • (2000) Immunology , vol.99 , pp. 375-384
    • Muller, B.1    Fischer, B.2    Kreutz, W.3
  • 170
    • 34247613216 scopus 로고    scopus 로고
    • Nitric oxide, a double edged sword in cancer biology: searching for therapeutic opportunities
    • Mocellin S, Bronte V, Nitti D. Nitric oxide, a double edged sword in cancer biology: searching for therapeutic opportunities. Med Res Rev (2007) 27:317-52. doi:10.1002/med.20092
    • (2007) Med Res Rev , vol.27 , pp. 317-352
    • Mocellin, S.1    Bronte, V.2    Nitti, D.3
  • 172
    • 0033559897 scopus 로고    scopus 로고
    • Peroxynitrite inhibits T lymphocyte activation and proliferation by promoting impairment of tyrosine phosphorylation and peroxynitrite-driven apoptotic death
    • Brito C, Naviliat M, Tiscornia AC, Vuillier F, Gualco G, Dighiero G, et al. Peroxynitrite inhibits T lymphocyte activation and proliferation by promoting impairment of tyrosine phosphorylation and peroxynitrite-driven apoptotic death. J Immunol (1999) 162:3356-66.
    • (1999) J Immunol , vol.162 , pp. 3356-3366
    • Brito, C.1    Naviliat, M.2    Tiscornia, A.C.3    Vuillier, F.4    Gualco, G.5    Dighiero, G.6
  • 173
    • 0035834101 scopus 로고    scopus 로고
    • Proteomic method identifies proteins nitrated in vivo during inflammatory challenge
    • Aulak KS, Miyagi M, Yan L, West KA, Massillon D, Crabb JW, et al. Proteomic method identifies proteins nitrated in vivo during inflammatory challenge. Proc Natl Acad Sci U S A (2001) 98:12056-61. doi:10.1073/pnas.221269198
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 12056-12061
    • Aulak, K.S.1    Miyagi, M.2    Yan, L.3    West, K.A.4    Massillon, D.5    Crabb, J.W.6
  • 174
    • 34447118098 scopus 로고    scopus 로고
    • Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer
    • Nagaraj S, Gupta K, Pisarev V, Kinarsky L, Sherman S, Kang L, et al. Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer. Nat Med (2007) 13:828-35. doi:10.1038/nm1609
    • (2007) Nat Med , vol.13 , pp. 828-835
    • Nagaraj, S.1    Gupta, K.2    Pisarev, V.3    Kinarsky, L.4    Sherman, S.5    Kang, L.6
  • 175
    • 79959762623 scopus 로고    scopus 로고
    • Modulation of human T-cell functions by reactive nitrogen species
    • Kasic T, Colombo P, Soldani C, Wang CM, Miranda E, Roncalli M, et al. Modulation of human T-cell functions by reactive nitrogen species. Eur J Immunol (2011) 41:1843-9. doi:10.1002/eji.201040868
    • (2011) Eur J Immunol , vol.41 , pp. 1843-1849
    • Kasic, T.1    Colombo, P.2    Soldani, C.3    Wang, C.M.4    Miranda, E.5    Roncalli, M.6
  • 176
    • 20944434107 scopus 로고    scopus 로고
    • Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers
    • Bronte V, Kasic T, Gri G, Gallana K, Borsellino G, Marigo I, et al. Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers. J Exp Med (2005) 201:1257-68. doi:10.1084/jem.20042028
    • (2005) J Exp Med , vol.201 , pp. 1257-1268
    • Bronte, V.1    Kasic, T.2    Gri, G.3    Gallana, K.4    Borsellino, G.5    Marigo, I.6
  • 177
    • 84941204281 scopus 로고    scopus 로고
    • Spotlights on immunological effects of reactive nitrogen species: when inflammation says nitric oxide
    • Predonzani A, Cali B, Agnellini AH, Molon B. Spotlights on immunological effects of reactive nitrogen species: when inflammation says nitric oxide. World J Exp Med (2015) 5:64-76. doi:10.5493/wjem.v5.i2.64
    • (2015) World J Exp Med , vol.5 , pp. 64-76
    • Predonzani, A.1    Cali, B.2    Agnellini, A.H.3    Molon, B.4
  • 178
    • 4143130091 scopus 로고    scopus 로고
    • Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses
    • Rodriguez PC, Quiceno DG, Zabaleta J, Ortiz B, Zea AH, Piazuelo MB, et al. Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses. Cancer Res (2004) 64:5839-49. doi:10.1158/0008-5472.CAN-04-0465
    • (2004) Cancer Res , vol.64 , pp. 5839-5849
    • Rodriguez, P.C.1    Quiceno, D.G.2    Zabaleta, J.3    Ortiz, B.4    Zea, A.H.5    Piazuelo, M.B.6
  • 179
    • 23444456772 scopus 로고    scopus 로고
    • Regulation of immune responses by L-arginine metabolism
    • Bronte V, Zanovello P. Regulation of immune responses by L-arginine metabolism. Nat Rev Immunol (2005) 5:641-54. doi:10.1038/nri1668
    • (2005) Nat Rev Immunol , vol.5 , pp. 641-654
    • Bronte, V.1    Zanovello, P.2
  • 180
    • 0842325861 scopus 로고    scopus 로고
    • Incidence and distribution of argininosuccinate synthetase deficiency in human cancers: a method for identifying cancers sensitive to arginine deprivation
    • Dillon BJ, Prieto VG, Curley SA, Ensor CM, Holtsberg FW, Bomalaski JS, et al. Incidence and distribution of argininosuccinate synthetase deficiency in human cancers: a method for identifying cancers sensitive to arginine deprivation. Cancer (2004) 100:826-33. doi:10.1002/cncr.20057
    • (2004) Cancer , vol.100 , pp. 826-833
    • Dillon, B.J.1    Prieto, V.G.2    Curley, S.A.3    Ensor, C.M.4    Holtsberg, F.W.5    Bomalaski, J.S.6
  • 181
    • 84893360415 scopus 로고    scopus 로고
    • Targeting arginine-dependent cancers with arginine-degrading enzymes: opportunities and challenges
    • Phillips MM, Sheaff MT, Szlosarek PW. Targeting arginine-dependent cancers with arginine-degrading enzymes: opportunities and challenges. Cancer Res Treat (2013) 45:251-62. doi:10.4143/crt.2013.45.4.251
    • (2013) Cancer Res Treat , vol.45 , pp. 251-262
    • Phillips, M.M.1    Sheaff, M.T.2    Szlosarek, P.W.3
  • 182
    • 75149123468 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine
    • Srivastava MK, Sinha P, Clements VK, Rodriguez P, Ostrand-Rosenberg S. Myeloid-derived suppressor cells inhibit T-cell activation by depleting cystine and cysteine. Cancer Res (2010) 70:68-77. doi:10.1158/0008-5472.CAN-09-2587
    • (2010) Cancer Res , vol.70 , pp. 68-77
    • Srivastava, M.K.1    Sinha, P.2    Clements, V.K.3    Rodriguez, P.4    Ostrand-Rosenberg, S.5
  • 183
    • 84875261622 scopus 로고    scopus 로고
    • Indoleamine 2,3 dioxygenase and metabolic control of immune responses
    • Munn DH, Mellor AL. Indoleamine 2,3 dioxygenase and metabolic control of immune responses. Trends Immunol (2013) 34:137-43. doi:10.1016/j.it.2012.10.001
    • (2013) Trends Immunol , vol.34 , pp. 137-143
    • Munn, D.H.1    Mellor, A.L.2
  • 185
    • 33845920042 scopus 로고    scopus 로고
    • Decreased serum tryptophan concentration predicts poor prognosis in malignant melanoma patients
    • Weinlich G, Murr C, Richardsen L, Winkler C, Fuchs D. Decreased serum tryptophan concentration predicts poor prognosis in malignant melanoma patients. Dermatology (2007) 214:8-14. doi:10.1159/000096906
    • (2007) Dermatology , vol.214 , pp. 8-14
    • Weinlich, G.1    Murr, C.2    Richardsen, L.3    Winkler, C.4    Fuchs, D.5
  • 186
    • 81255138408 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase expression in human cancers: clinical and immunologic perspectives
    • Godin-Ethier J, Hanafi LA, Piccirillo CA, Lapointe R. Indoleamine 2,3-dioxygenase expression in human cancers: clinical and immunologic perspectives. Clin Cancer Res (2011) 17:6985-91. doi:10.1158/1078-0432.CCR-11-1331
    • (2011) Clin Cancer Res , vol.17 , pp. 6985-6991
    • Godin-Ethier, J.1    Hanafi, L.A.2    Piccirillo, C.A.3    Lapointe, R.4
  • 187
    • 84862145949 scopus 로고    scopus 로고
    • Tumor metabolism as modulator of immune response and tumor progression
    • Gottfried E, Kreutz M, Mackensen A. Tumor metabolism as modulator of immune response and tumor progression. Semin Cancer Biol (2012) 22:335-41. doi:10.1016/j.semcancer.2012.02.009
    • (2012) Semin Cancer Biol , vol.22 , pp. 335-341
    • Gottfried, E.1    Kreutz, M.2    Mackensen, A.3
  • 188
    • 5044250291 scopus 로고    scopus 로고
    • Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase
    • Mellor AL, Chandler P, Baban B, Hansen AM, Marshall B, Pihkala J, et al. Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase. Int Immunol (2004) 16:1391-401. doi:10.1093/intimm/dxh140
    • (2004) Int Immunol , vol.16 , pp. 1391-1401
    • Mellor, A.L.1    Chandler, P.2    Baban, B.3    Hansen, A.M.4    Marshall, B.5    Pihkala, J.6
  • 190
    • 78649704325 scopus 로고    scopus 로고
    • Autophagy and metabolism
    • Rabinowitz JD, White E. Autophagy and metabolism. Science (2010) 330:1344-8. doi:10.1126/science.1193497
    • (2010) Science , vol.330 , pp. 1344-1348
    • Rabinowitz, J.D.1    White, E.2
  • 191
    • 79251587803 scopus 로고    scopus 로고
    • Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy
    • Egan DF, Shackelford DB, Mihaylova MM, Gelino S, Kohnz RA, Mair W, et al. Phosphorylation of ULK1 (hATG1) by AMP-activated protein kinase connects energy sensing to mitophagy. Science (2011) 331:456-61. doi:10.1126/science.1196371
    • (2011) Science , vol.331 , pp. 456-461
    • Egan, D.F.1    Shackelford, D.B.2    Mihaylova, M.M.3    Gelino, S.4    Kohnz, R.A.5    Mair, W.6
  • 192
    • 79952703288 scopus 로고    scopus 로고
    • Cell metabolism: an essential link between cell growth and apoptosis
    • Mason EF, Rathmell JC. Cell metabolism: an essential link between cell growth and apoptosis. Biochim Biophys Acta (2011) 1813:645-54. doi:10.1016/j.bbamcr.2010.08.011
    • (2011) Biochim Biophys Acta , vol.1813 , pp. 645-654
    • Mason, E.F.1    Rathmell, J.C.2
  • 193
    • 67749111502 scopus 로고    scopus 로고
    • The LKB1-AMPK pathway: metabolism and growth control in tumour suppression
    • Shackelford DB, Shaw RJ. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat Rev Cancer (2009) 9:563-75. doi:10.1038/nrc2676
    • (2009) Nat Rev Cancer , vol.9 , pp. 563-575
    • Shackelford, D.B.1    Shaw, R.J.2
  • 194
    • 84907228811 scopus 로고    scopus 로고
    • Metformin attenuates experimental autoimmune arthritis through reciprocal regulation of Th17/Treg balance and osteoclastogenesis
    • Son HJ, Lee J, Lee SY, Kim EK, Park MJ, Kim KW, et al. Metformin attenuates experimental autoimmune arthritis through reciprocal regulation of Th17/Treg balance and osteoclastogenesis. Mediators Inflamm (2014) 2014:973986. doi:10.1155/2014/973986
    • (2014) Mediators Inflamm , vol.2014 , pp. 973986
    • Son, H.J.1    Lee, J.2    Lee, S.Y.3    Kim, E.K.4    Park, M.J.5    Kim, K.W.6
  • 195
    • 84922481111 scopus 로고    scopus 로고
    • Aryl hydrocarbon receptor ligands in cancer: friend and foe
    • Murray IA, Patterson AD, Perdew GH. Aryl hydrocarbon receptor ligands in cancer: friend and foe. Nat Rev Cancer (2014) 14:801-14. doi:10.1038/nrc3846
    • (2014) Nat Rev Cancer , vol.14 , pp. 801-814
    • Murray, I.A.1    Patterson, A.D.2    Perdew, G.H.3
  • 196
    • 0348223787 scopus 로고    scopus 로고
    • Conversion of peripheral CD4+CD25-naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3
    • Chen W, Jin W, Hardegen N, Lei KJ, Li L, Marinos N, et al. Conversion of peripheral CD4+CD25-naive T cells to CD4+CD25+ regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med (2003) 198:1875-86. doi:10.1084/jem.20030152
    • (2003) J Exp Med , vol.198 , pp. 1875-1886
    • Chen, W.1    Jin, W.2    Hardegen, N.3    Lei, K.J.4    Li, L.5    Marinos, N.6
  • 197
    • 4644237613 scopus 로고    scopus 로고
    • Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival
    • Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, Mottram P, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat Med (2004) 10:942-9. doi:10.1038/nm1093
    • (2004) Nat Med , vol.10 , pp. 942-949
    • Curiel, T.J.1    Coukos, G.2    Zou, L.3    Alvarez, X.4    Cheng, P.5    Mottram, P.6
  • 198
    • 77954704449 scopus 로고    scopus 로고
    • Prognostic significance of regulatory T cells in tumor
    • Wilke CM, Wu K, Zhao E, Wang G, Zou W. Prognostic significance of regulatory T cells in tumor. Int J Cancer (2010) 127:748-58. doi:10.1002/ijc.25464
    • (2010) Int J Cancer , vol.127 , pp. 748-758
    • Wilke, C.M.1    Wu, K.2    Zhao, E.3    Wang, G.4    Zou, W.5
  • 199
    • 84989966066 scopus 로고    scopus 로고
    • Foxp3 and toll-like receptor signaling balance Treg cell anabolic metabolism for suppression
    • Gerriets VA, Kishton RJ, Johnson MO, Cohen S, Siska PJ, Nichols AG, et al. Foxp3 and toll-like receptor signaling balance Treg cell anabolic metabolism for suppression. Nat Immunol (2016) 17:1459-66. doi:10.1038/ni.3577
    • (2016) Nat Immunol , vol.17 , pp. 1459-1466
    • Gerriets, V.A.1    Kishton, R.J.2    Johnson, M.O.3    Cohen, S.4    Siska, P.J.5    Nichols, A.G.6
  • 200
    • 84904057246 scopus 로고    scopus 로고
    • The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function
    • Macintyre AN, Gerriets VA, Nichols AG, Michalek RD, Rudolph MC, Deoliveira D, et al. The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. Cell Metab (2014) 20:61-72. doi:10.1016/j.cmet.2014.05.004
    • (2014) Cell Metab , vol.20 , pp. 61-72
    • Macintyre, A.N.1    Gerriets, V.A.2    Nichols, A.G.3    Michalek, R.D.4    Rudolph, M.C.5    Deoliveira, D.6
  • 201
    • 84876514626 scopus 로고    scopus 로고
    • Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
    • Sinclair LV, Rolf J, Emslie E, Shi YB, Taylor PM, Cantrell DA. Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation. Nat Immunol (2013) 14:500-8. doi:10.1038/ni.2556
    • (2013) Nat Immunol , vol.14 , pp. 500-508
    • Sinclair, L.V.1    Rolf, J.2    Emslie, E.3    Shi, Y.B.4    Taylor, P.M.5    Cantrell, D.A.6
  • 202
    • 34247184208 scopus 로고    scopus 로고
    • Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking
    • Wieman HL, Wofford JA, Rathmell JC. Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. Mol Biol Cell (2007) 18:1437-46. doi:10.1091/mbc.E06-07-0593
    • (2007) Mol Biol Cell , vol.18 , pp. 1437-1446
    • Wieman, H.L.1    Wofford, J.A.2    Rathmell, J.C.3
  • 203
    • 84877924054 scopus 로고    scopus 로고
    • Nutrient transporters: the Achilles' heel of anabolism
    • McCracken AN, Edinger AL. Nutrient transporters: the Achilles' heel of anabolism. Trends Endocrinol Metab (2013) 24:200-8. doi:10.1016/j.tem.2013.01.002
    • (2013) Trends Endocrinol Metab , vol.24 , pp. 200-208
    • McCracken, A.N.1    Edinger, A.L.2
  • 206
    • 84870922385 scopus 로고    scopus 로고
    • Network analysis reveals centrally connected genes and pathways involved in CD8+ T cell exhaustion versus memory
    • Doering TA, Crawford A, Angelosanto JM, Paley MA, Ziegler CG, Wherry EJ. Network analysis reveals centrally connected genes and pathways involved in CD8+ T cell exhaustion versus memory. Immunity (2012) 37:1130-44. doi:10.1016/j.immuni.2012.08.021
    • (2012) Immunity , vol.37 , pp. 1130-1144
    • Doering, T.A.1    Crawford, A.2    Angelosanto, J.M.3    Paley, M.A.4    Ziegler, C.G.5    Wherry, E.J.6
  • 207
    • 70349459931 scopus 로고    scopus 로고
    • PD-1+ memory phenotype CD4+ T cells expressing C/EBPalpha underlie T cell immunodepression in senescence and leukemia
    • Shimatani K, Nakashima Y, Hattori M, Hamazaki Y, Minato N. PD-1+ memory phenotype CD4+ T cells expressing C/EBPalpha underlie T cell immunodepression in senescence and leukemia. Proc Natl Acad Sci U S A (2009) 106:15807-12. doi:10.1073/pnas.0908805106
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 15807-15812
    • Shimatani, K.1    Nakashima, Y.2    Hattori, M.3    Hamazaki, Y.4    Minato, N.5
  • 208
    • 84881308659 scopus 로고    scopus 로고
    • PD-1 increases PTEN phosphatase activity while decreasing PTEN protein stability by inhibiting casein kinase 2
    • Patsoukis N, Li L, Sari D, Petkova V, Boussiotis VA. PD-1 increases PTEN phosphatase activity while decreasing PTEN protein stability by inhibiting casein kinase 2. Mol Cell Biol (2013) 33:3091-8. doi:10.1128/MCB.00319-13
    • (2013) Mol Cell Biol , vol.33 , pp. 3091-3098
    • Patsoukis, N.1    Li, L.2    Sari, D.3    Petkova, V.4    Boussiotis, V.A.5
  • 209
    • 84891708632 scopus 로고    scopus 로고
    • Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality
    • Saha A, Aoyama K, Taylor PA, Koehn BH, Veenstra RG, Panoskaltsis-Mortari A, et al. Host programmed death ligand 1 is dominant over programmed death ligand 2 expression in regulating graft-versus-host disease lethality. Blood (2013) 122:3062-73. doi:10.1182/blood-2013-05-500801
    • (2013) Blood , vol.122 , pp. 3062-3073
    • Saha, A.1    Aoyama, K.2    Taylor, P.A.3    Koehn, B.H.4    Veenstra, R.G.5    Panoskaltsis-Mortari, A.6
  • 210
    • 84961289524 scopus 로고    scopus 로고
    • Confusing signals: recent progress in CTLA-4 biology
    • Walker LS, Sansom DM. Confusing signals: recent progress in CTLA-4 biology. Trends Immunol (2015) 36:63-70. doi:10.1016/j.it.2014.12.001
    • (2015) Trends Immunol , vol.36 , pp. 63-70
    • Walker, L.S.1    Sansom, D.M.2
  • 211
    • 84907810196 scopus 로고    scopus 로고
    • PD-1 regulates extrathymic regulatory T-cell differentiation
    • Chen X, Fosco D, Kline DE, Meng L, Nishi S, Savage PA, et al. PD-1 regulates extrathymic regulatory T-cell differentiation. Eur J Immunol (2014) 44:2603-16. doi:10.1002/eji.201344423
    • (2014) Eur J Immunol , vol.44 , pp. 2603-2616
    • Chen, X.1    Fosco, D.2    Kline, D.E.3    Meng, L.4    Nishi, S.5    Savage, P.A.6
  • 212
    • 78649378225 scopus 로고    scopus 로고
    • The role of regulatory T cells in cancer
    • Ha TY. The role of regulatory T cells in cancer. Immune Netw (2009) 9:209-35. doi:10.4110/in.2009.9.6.209
    • (2009) Immune Netw , vol.9 , pp. 209-235
    • Ha, T.Y.1
  • 213
    • 84862135169 scopus 로고    scopus 로고
    • What are regulatory T cells (Treg) regulating in cancer and why?
    • Whiteside TL. What are regulatory T cells (Treg) regulating in cancer and why? Semin Cancer Biol (2012) 22:327-34. doi:10.1016/j.semcancer.2012.03.004
    • (2012) Semin Cancer Biol , vol.22 , pp. 327-334
    • Whiteside, T.L.1
  • 214
    • 84925688346 scopus 로고    scopus 로고
    • PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
    • Patsoukis N, Bardhan K, Chatterjee P, Sari D, Liu B, Bell LN, et al. PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation. Nat Commun (2015) 6:6692. doi:10.1038/ncomms7692
    • (2015) Nat Commun , vol.6 , pp. 6692
    • Patsoukis, N.1    Bardhan, K.2    Chatterjee, P.3    Sari, D.4    Liu, B.5    Bell, L.N.6
  • 215
    • 84918591282 scopus 로고    scopus 로고
    • Mechanisms of hypoxia-mediated immune escape in cancer
    • Barsoum IB, Koti M, Siemens DR, Graham CH. Mechanisms of hypoxia-mediated immune escape in cancer. Cancer Res (2014) 74:7185-90. doi:10.1158/0008-5472.CAN-14-2598
    • (2014) Cancer Res , vol.74 , pp. 7185-7190
    • Barsoum, I.B.1    Koti, M.2    Siemens, D.R.3    Graham, C.H.4
  • 216
    • 41449109639 scopus 로고    scopus 로고
    • Augmented serum level of major histocompatibility complex class I-related chain A (MICA) protein and reduced NKG2D expression on NK and T cells in patients with cervical cancer and precursor lesions
    • Arreygue-Garcia NA, Daneri-Navarro A, del Toro-Arreola A, Cid-Arregui A, Gonzalez-Ramella O, Jave-Suarez LF, et al. Augmented serum level of major histocompatibility complex class I-related chain A (MICA) protein and reduced NKG2D expression on NK and T cells in patients with cervical cancer and precursor lesions. BMC Cancer (2008) 8:16. doi:10.1186/1471-2407-8-16
    • (2008) BMC Cancer , vol.8 , pp. 16
    • Arreygue-Garcia, N.A.1    Daneri-Navarro, A.2    del Toro-Arreola, A.3    Cid-Arregui, A.4    Gonzalez-Ramella, O.5    Jave-Suarez, L.F.6
  • 217
    • 84255170452 scopus 로고    scopus 로고
    • Hypoxia induces escape from innate immunity in cancer cells via increased expression of ADAM10: role of nitric oxide
    • Barsoum IB, Hamilton TK, Li X, Cotechini T, Miles EA, Siemens DR, et al. Hypoxia induces escape from innate immunity in cancer cells via increased expression of ADAM10: role of nitric oxide. Cancer Res (2011) 71:7433-41. doi:10.1158/0008-5472.CAN-11-2104
    • (2011) Cancer Res , vol.71 , pp. 7433-7441
    • Barsoum, I.B.1    Hamilton, T.K.2    Li, X.3    Cotechini, T.4    Miles, E.A.5    Siemens, D.R.6
  • 218
    • 70349569569 scopus 로고    scopus 로고
    • Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired
    • Ahmadzadeh M, Johnson LA, Heemskerk B, Wunderlich JR, Dudley ME, White DE, et al. Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired. Blood (2009) 114:1537-44. doi:10.1182/blood-2008-12-195792
    • (2009) Blood , vol.114 , pp. 1537-1544
    • Ahmadzadeh, M.1    Johnson, L.A.2    Heemskerk, B.3    Wunderlich, J.R.4    Dudley, M.E.5    White, D.E.6
  • 220
    • 84945443762 scopus 로고    scopus 로고
    • Associations among pretreatment tumor necrosis and the expression of HIF-1alpha and PD-L1 in advanced oral squamous cell carcinoma and the prognostic impact thereof
    • Chen TC, Wu CT, Wang CP, Hsu WL, Yang TL, Lou PJ, et al. Associations among pretreatment tumor necrosis and the expression of HIF-1alpha and PD-L1 in advanced oral squamous cell carcinoma and the prognostic impact thereof. Oral Oncol (2015) 51:1004-10. doi:10.1016/j.oraloncology.2015.08.011
    • (2015) Oral Oncol , vol.51 , pp. 1004-1010
    • Chen, T.C.1    Wu, C.T.2    Wang, C.P.3    Hsu, W.L.4    Yang, T.L.5    Lou, P.J.6
  • 221
    • 84893872087 scopus 로고    scopus 로고
    • A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells
    • Barsoum IB, Smallwood CA, Siemens DR, Graham CH. A mechanism of hypoxia-mediated escape from adaptive immunity in cancer cells. Cancer Res (2014) 74:665-74. doi:10.1158/0008-5472.CAN-14-2598
    • (2014) Cancer Res , vol.74 , pp. 665-674
    • Barsoum, I.B.1    Smallwood, C.A.2    Siemens, D.R.3    Graham, C.H.4
  • 222
    • 84865335195 scopus 로고    scopus 로고
    • Metabolic reprogramming of cancer-associated fibroblasts by TGF-beta drives tumor growth: connecting TGF-beta signaling with "Warburg-like" cancer metabolism and L-lactate production
    • Guido C, Whitaker-Menezes D, Capparelli C, Balliet R, Lin Z, Pestell RG, et al. Metabolic reprogramming of cancer-associated fibroblasts by TGF-beta drives tumor growth: connecting TGF-beta signaling with "Warburg-like" cancer metabolism and L-lactate production. Cell Cycle (2012) 11:3019-35. doi:10.4161/cc.21384
    • (2012) Cell Cycle , vol.11 , pp. 3019-3035
    • Guido, C.1    Whitaker-Menezes, D.2    Capparelli, C.3    Balliet, R.4    Lin, Z.5    Pestell, R.G.6
  • 223
    • 84868625980 scopus 로고    scopus 로고
    • Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth
    • Guido C, Whitaker-Menezes D, Lin Z, Pestell RG, Howell A, Zimmers TA, et al. Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth. Oncotarget (2012) 3:798-810. doi:10.18632/oncotarget.574
    • (2012) Oncotarget , vol.3 , pp. 798-810
    • Guido, C.1    Whitaker-Menezes, D.2    Lin, Z.3    Pestell, R.G.4    Howell, A.5    Zimmers, T.A.6
  • 224
    • 85019040493 scopus 로고    scopus 로고
    • Phospholipase D1-regulated autophagy supplies free fatty acids to counter nutrient stress in cancer cells
    • Cai M, He J, Xiong J, Tay LW, Wang Z, Rog C, et al. Phospholipase D1-regulated autophagy supplies free fatty acids to counter nutrient stress in cancer cells. Cell Death Dis (2016) 7:e2448. doi:10.1038/cddis.2016.355
    • (2016) Cell Death Dis , vol.7
    • Cai, M.1    He, J.2    Xiong, J.3    Tay, L.W.4    Wang, Z.5    Rog, C.6
  • 225
    • 47749139256 scopus 로고    scopus 로고
    • Cancer as an overhealing wound: an old hypothesis revisited
    • Schafer M, Werner S. Cancer as an overhealing wound: an old hypothesis revisited. Nat Rev Mol Cell Biol (2008) 9:628-38. doi:10.1038/nrm2455
    • (2008) Nat Rev Mol Cell Biol , vol.9 , pp. 628-638
    • Schafer, M.1    Werner, S.2
  • 226
    • 74849087878 scopus 로고    scopus 로고
    • The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma
    • Pavlides S, Whitaker-Menezes D, Castello-Cros R, Flomenberg N, Witkiewicz AK, Frank PG, et al. The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma. Cell Cycle (2009) 8:3984-4001. doi:10.4161/cc.8.23.10238
    • (2009) Cell Cycle , vol.8 , pp. 3984-4001
    • Pavlides, S.1    Whitaker-Menezes, D.2    Castello-Cros, R.3    Flomenberg, N.4    Witkiewicz, A.K.5    Frank, P.G.6
  • 227
    • 84870952346 scopus 로고    scopus 로고
    • BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment: implications for breast cancer prevention with antioxidant therapies
    • Martinez-Outschoorn UE, Balliet R, Lin Z, Whitaker-Menezes D, Birbe RC, Bombonati A, et al. BRCA1 mutations drive oxidative stress and glycolysis in the tumor microenvironment: implications for breast cancer prevention with antioxidant therapies. Cell Cycle (2012) 11:4402-13. doi:10.4161/cc.22776
    • (2012) Cell Cycle , vol.11 , pp. 4402-4413
    • Martinez-Outschoorn, U.E.1    Balliet, R.2    Lin, Z.3    Whitaker-Menezes, D.4    Birbe, R.C.5    Bombonati, A.6
  • 228
    • 84943328733 scopus 로고    scopus 로고
    • The study of energy metabolism in bladder cancer cells in co-culture conditions using a microfluidic chip
    • Xu XD, Shao SX, Cao YW, Yang XC, Shi HQ, Wang YL, et al. The study of energy metabolism in bladder cancer cells in co-culture conditions using a microfluidic chip. Int J Clin Exp Med (2015) 8:12327-36.
    • (2015) Int J Clin Exp Med , vol.8 , pp. 12327-12336
    • Xu, X.D.1    Shao, S.X.2    Cao, Y.W.3    Yang, X.C.4    Shi, H.Q.5    Wang, Y.L.6
  • 229
    • 84990990016 scopus 로고    scopus 로고
    • Cytoplasmic GPER translocation in cancer-associated fibroblasts mediates cAMP/PKA/CREB/glycolytic axis to confer tumor cells with multidrug resistance
    • Yu T, Yang G, Hou Y, Tang X, Wu C, Wu XA, et al. Cytoplasmic GPER translocation in cancer-associated fibroblasts mediates cAMP/PKA/CREB/glycolytic axis to confer tumor cells with multidrug resistance. Oncogene (2016) 1-15. doi:10.1038/onc.2016.370
    • (2016) Oncogene , pp. 1-15
    • Yu, T.1    Yang, G.2    Hou, Y.3    Tang, X.4    Wu, C.5    Wu, X.A.6
  • 230
    • 84984685578 scopus 로고    scopus 로고
    • Cancer: an oxidative crosstalk between solid tumor cells and cancer associated fibroblasts
    • Arcucci A, Ruocco MR, Granato G, Sacco AM, Montagnani S. Cancer: an oxidative crosstalk between solid tumor cells and cancer associated fibroblasts. Biomed Res Int (2016) 2016:4502846. doi:10.1155/2016/4502846
    • (2016) Biomed Res Int , vol.2016 , pp. 4502846
    • Arcucci, A.1    Ruocco, M.R.2    Granato, G.3    Sacco, A.M.4    Montagnani, S.5
  • 231
    • 84901597401 scopus 로고    scopus 로고
    • A lactate shuttle system between tumour and stromal cells is associated with poor prognosis in prostate cancer
    • Pertega-Gomes N, Vizcaino JR, Attig J, Jurmeister S, Lopes C, Baltazar F. A lactate shuttle system between tumour and stromal cells is associated with poor prognosis in prostate cancer. BMC Cancer (2014) 14:352. doi:10.1186/1471-2407-14-352
    • (2014) BMC Cancer , vol.14 , pp. 352
    • Pertega-Gomes, N.1    Vizcaino, J.R.2    Attig, J.3    Jurmeister, S.4    Lopes, C.5    Baltazar, F.6
  • 232
    • 84916224406 scopus 로고    scopus 로고
    • Expression of lactate/H(+) symporters MCT1 and MCT4 and their chaperone CD147 predicts tumor progression in clear cell renal cell carcinoma: immunohistochemical and the Cancer Genome Atlas data analyses
    • Kim Y, Choi JW, Lee JH, Kim YS. Expression of lactate/H(+) symporters MCT1 and MCT4 and their chaperone CD147 predicts tumor progression in clear cell renal cell carcinoma: immunohistochemical and the Cancer Genome Atlas data analyses. Hum Pathol (2015) 46:104-12. doi:10.1016/j.humpath.2014.09.013
    • (2015) Hum Pathol , vol.46 , pp. 104-112
    • Kim, Y.1    Choi, J.W.2    Lee, J.H.3    Kim, Y.S.4
  • 233
    • 84979950555 scopus 로고    scopus 로고
    • Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas
    • Miranda-Goncalves V, Granja S, Martinho O, Honavar M, Pojo M, Costa BM, et al. Hypoxia-mediated upregulation of MCT1 expression supports the glycolytic phenotype of glioblastomas. Oncotarget (2016) 7:46335-53. doi:10.18632/oncotarget.10114
    • (2016) Oncotarget , vol.7 , pp. 46335-46353
    • Miranda-Goncalves, V.1    Granja, S.2    Martinho, O.3    Honavar, M.4    Pojo, M.5    Costa, B.M.6
  • 234
    • 84998812275 scopus 로고    scopus 로고
    • Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential
    • Knudsen ES, Balaji U, Freinkman E, McCue P, Witkiewicz AK. Unique metabolic features of pancreatic cancer stroma: relevance to the tumor compartment, prognosis, and invasive potential. Oncotarget (2016) 7(48):78396-411. doi:10.18632/oncotarget.11893
    • (2016) Oncotarget , vol.7 , Issue.48 , pp. 78396-78411
    • Knudsen, E.S.1    Balaji, U.2    Freinkman, E.3    McCue, P.4    Witkiewicz, A.K.5
  • 235
    • 0001041668 scopus 로고    scopus 로고
    • The effect of extracellular pH on angiogenesis in vitro
    • Burbridge MF, West DC, Atassi G, Tucker GC. The effect of extracellular pH on angiogenesis in vitro. Angiogenesis (1999) 3:281-8. doi:10.1023/A:1009092511894
    • (1999) Angiogenesis , vol.3 , pp. 281-288
    • Burbridge, M.F.1    West, D.C.2    Atassi, G.3    Tucker, G.C.4
  • 236
    • 84876181793 scopus 로고    scopus 로고
    • Acidosis activation of the proton-sensing GPR4 receptor stimulates vascular endothelial cell inflammatory responses revealed by transcriptome analysis
    • Dong L, Li Z, Leffler NR, Asch AS, Chi JT, Yang LV. Acidosis activation of the proton-sensing GPR4 receptor stimulates vascular endothelial cell inflammatory responses revealed by transcriptome analysis. PLoS One (2013) 8:e61991. doi:10.1371/journal.pone.0061991
    • (2013) PLoS One , vol.8
    • Dong, L.1    Li, Z.2    Leffler, N.R.3    Asch, A.S.4    Chi, J.T.5    Yang, L.V.6
  • 237
    • 84924576198 scopus 로고    scopus 로고
    • Metabolic reprogramming of cancer-associated fibroblasts by IDH3alpha downregulation
    • Zhang D, Wang Y, Shi Z, Liu J, Sun P, Hou X, et al. Metabolic reprogramming of cancer-associated fibroblasts by IDH3alpha downregulation. Cell Rep (2015) 10:1335-48. doi:10.1016/j.celrep.2015.02.006
    • (2015) Cell Rep , vol.10 , pp. 1335-1348
    • Zhang, D.1    Wang, Y.2    Shi, Z.3    Liu, J.4    Sun, P.5    Hou, X.6
  • 238
    • 85006294865 scopus 로고    scopus 로고
    • TP53-inducible glycolysis and apoptosis regulator (TIGAR) metabolically reprograms carcinoma and stromal cells in breast cancer
    • Ko YH, Domingo-Vidal M, Roche M, Lin Z, Whitaker-Menezes D, Seifert E, et al. TP53-inducible glycolysis and apoptosis regulator (TIGAR) metabolically reprograms carcinoma and stromal cells in breast cancer. J Biol Chem (2016) 291:26291-303. doi:10.1074/jbc.M116.740209
    • (2016) J Biol Chem , vol.291 , pp. 26291-26303
    • Ko, Y.H.1    Domingo-Vidal, M.2    Roche, M.3    Lin, Z.4    Whitaker-Menezes, D.5    Seifert, E.6
  • 239
    • 0030921103 scopus 로고    scopus 로고
    • c-Myc transactivation of LDH-A: implications for tumor metabolism and growth
    • Shim H, Dolde C, Lewis BC, Wu CS, Dang G, Jungmann RA, et al. c-Myc transactivation of LDH-A: implications for tumor metabolism and growth. Proc Natl Acad Sci U S A (1997) 94:6658-63. doi:10.1073/pnas.94.13.6658
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 6658-6663
    • Shim, H.1    Dolde, C.2    Lewis, B.C.3    Wu, C.S.4    Dang, G.5    Jungmann, R.A.6
  • 241
    • 84855991449 scopus 로고    scopus 로고
    • Regulatory role of p53 in cancer metabolism via SCO2 and TIGAR in human breast cancer
    • Won KY, Lim SJ, Kim GY, Kim YW, Han SA, Song JY, et al. Regulatory role of p53 in cancer metabolism via SCO2 and TIGAR in human breast cancer. Hum Pathol (2012) 43:221-8. doi:10.1016/j.humpath.2011.04.021
    • (2012) Hum Pathol , vol.43 , pp. 221-228
    • Won, K.Y.1    Lim, S.J.2    Kim, G.Y.3    Kim, Y.W.4    Han, S.A.5    Song, J.Y.6
  • 242
    • 84983461877 scopus 로고    scopus 로고
    • Glioblastoma cells induce differential glutamatergic gene expressions in human tumor-associated microglia/macrophages and monocyte-derived macrophages
    • Choi J, Stradmann-Bellinghausen B, Yakubov E, Savaskan NE, Regnier-Vigouroux A. Glioblastoma cells induce differential glutamatergic gene expressions in human tumor-associated microglia/macrophages and monocyte-derived macrophages. Cancer Biol Ther (2015) 16:1205-13. doi:10.1080/15384047.2015.1056406
    • (2015) Cancer Biol Ther , vol.16 , pp. 1205-1213
    • Choi, J.1    Stradmann-Bellinghausen, B.2    Yakubov, E.3    Savaskan, N.E.4    Regnier-Vigouroux, A.5
  • 243
    • 84999273647 scopus 로고    scopus 로고
    • Autophagy is required for PDAC glutamine metabolism
    • Seo JW, Choi J, Lee SY, Sung S, Yoo HJ, Kang MJ, et al. Autophagy is required for PDAC glutamine metabolism. Sci Rep (2016) 6:37594. doi:10.1038/srep37594
    • (2016) Sci Rep , vol.6 , pp. 37594
    • Seo, J.W.1    Choi, J.2    Lee, S.Y.3    Sung, S.4    Yoo, H.J.5    Kang, M.J.6
  • 245
    • 81255157465 scopus 로고    scopus 로고
    • Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth
    • Nieman KM, Kenny HA, Penicka CV, Ladanyi A, Buell-Gutbrod R, Zillhardt MR, et al. Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth. Nat Med (2011) 17:1498-503. doi:10.1038/nm.2492
    • (2011) Nat Med , vol.17 , pp. 1498-1503
    • Nieman, K.M.1    Kenny, H.A.2    Penicka, C.V.3    Ladanyi, A.4    Buell-Gutbrod, R.5    Zillhardt, M.R.6
  • 246
    • 84859183441 scopus 로고    scopus 로고
    • Mature breast adipocytes promote breast cancer cell motility
    • Carter JC, Church FC. Mature breast adipocytes promote breast cancer cell motility. Exp Mol Pathol (2012) 92:312-7. doi:10.1016/j.yexmp.2012.03.005
    • (2012) Exp Mol Pathol , vol.92 , pp. 312-317
    • Carter, J.C.1    Church, F.C.2
  • 247
    • 84866135453 scopus 로고    scopus 로고
    • Adipocyte-released insulin-like growth factor-1 is regulated by glucose and fatty acids and controls breast cancer cell growth in vitro
    • D'Esposito V, Passaretti F, Hammarstedt A, Liguoro D, Terracciano D, Molea G, et al. Adipocyte-released insulin-like growth factor-1 is regulated by glucose and fatty acids and controls breast cancer cell growth in vitro. Diabetologia (2012) 55:2811-22. doi:10.1007/s00125-012-2629-7
    • (2012) Diabetologia , vol.55 , pp. 2811-2822
    • D'Esposito, V.1    Passaretti, F.2    Hammarstedt, A.3    Liguoro, D.4    Terracciano, D.5    Molea, G.6
  • 248
    • 85018029467 scopus 로고    scopus 로고
    • Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration
    • Balaban S, Shearer RF, Lee LS, van Geldermalsen M, Schreuder M, Shtein HC, et al. Adipocyte lipolysis links obesity to breast cancer growth: adipocyte-derived fatty acids drive breast cancer cell proliferation and migration. Cancer Metab (2017) 5:1. doi:10.1186/s40170-016-0163-7
    • (2017) Cancer Metab , vol.5 , pp. 1
    • Balaban, S.1    Shearer, R.F.2    Lee, L.S.3    van Geldermalsen, M.4    Schreuder, M.5    Shtein, H.C.6
  • 249
    • 85011578854 scopus 로고    scopus 로고
    • Adipocytes activate mitochondrial fatty acid oxidation and autophagy to promote tumor growth in colon cancer
    • Wen YA, Xing X, Harris JW, Zaytseva YY, Mitov MI, Napier DL, et al. Adipocytes activate mitochondrial fatty acid oxidation and autophagy to promote tumor growth in colon cancer. Cell Death Dis (2017) 8:e2593. doi:10.1038/cddis.2017.21
    • (2017) Cell Death Dis , vol.8
    • Wen, Y.A.1    Xing, X.2    Harris, J.W.3    Zaytseva, Y.Y.4    Mitov, M.I.5    Napier, D.L.6
  • 250
    • 85013135275 scopus 로고    scopus 로고
    • The peritumoural adipose tissue microenvironment and cancer
    • The roles of fatty acid binding protein 4 and fatty acid binding protein 5. Mol Cell Endocrinol
    • Guaita-Esteruelas S, Guma J, Masana L, Borras J. The peritumoural adipose tissue microenvironment and cancer. The roles of fatty acid binding protein 4 and fatty acid binding protein 5. Mol Cell Endocrinol (2017). doi:10.1016/j.mce.2017.02.002
    • (2017)
    • Guaita-Esteruelas, S.1    Guma, J.2    Masana, L.3    Borras, J.4
  • 251
    • 34548178349 scopus 로고    scopus 로고
    • Direct evidence of lipid translocation between adipocytes and prostate cancer cells with imaging FTIR microspectroscopy
    • Gazi E, Gardner P, Lockyer NP, Hart CA, Brown MD, Clarke NW. Direct evidence of lipid translocation between adipocytes and prostate cancer cells with imaging FTIR microspectroscopy. J Lipid Res (2007) 48:1846-56. doi:10.1194/jlr.M700131-JLR200
    • (2007) J Lipid Res , vol.48 , pp. 1846-1856
    • Gazi, E.1    Gardner, P.2    Lockyer, N.P.3    Hart, C.A.4    Brown, M.D.5    Clarke, N.W.6
  • 252
  • 253
    • 85013152324 scopus 로고    scopus 로고
    • Lipid metabolism fuels cancer's spread
    • Li Z, Kang Y. Lipid metabolism fuels cancer's spread. Cell Metab (2017) 25:228-30. doi:10.1016/j.cmet.2017.01.016
    • (2017) Cell Metab , vol.25 , pp. 228-230
    • Li, Z.1    Kang, Y.2
  • 254
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: the metabolic requirements of cell proliferation
    • Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science (2009) 324:1029-33. doi:10.1126/science.1160809
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 255
    • 77950546594 scopus 로고    scopus 로고
    • Dominant uptake of fatty acid over glucose by prostate cells: a potential new diagnostic and therapeutic approach
    • Liu Y, Zuckier LS, Ghesani NV. Dominant uptake of fatty acid over glucose by prostate cells: a potential new diagnostic and therapeutic approach. Anticancer Res (2010) 30:369-74.
    • (2010) Anticancer Res , vol.30 , pp. 369-374
    • Liu, Y.1    Zuckier, L.S.2    Ghesani, N.V.3
  • 256
    • 84977511570 scopus 로고    scopus 로고
    • Aberrant lipid metabolism promotes prostate cancer: role in cell survival under hypoxia and extracellular vesicles biogenesis
    • Deep G, Schlaepfer IR. Aberrant lipid metabolism promotes prostate cancer: role in cell survival under hypoxia and extracellular vesicles biogenesis. Int J Mol Sci (2016) 17:1061-74. doi:10.3390/ijms17071061
    • (2016) Int J Mol Sci , vol.17 , pp. 1061-1074
    • Deep, G.1    Schlaepfer, I.R.2
  • 257
    • 84912111808 scopus 로고    scopus 로고
    • The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infection
    • Staron MM, Gray SM, Marshall HD, Parish IA, Chen JH, Perry CJ, et al. The transcription factor FoxO1 sustains expression of the inhibitory receptor PD-1 and survival of antiviral CD8(+) T cells during chronic infection. Immunity (2014) 41:802-14. doi:10.1016/j.immuni.2014.10.013
    • (2014) Immunity , vol.41 , pp. 802-814
    • Staron, M.M.1    Gray, S.M.2    Marshall, H.D.3    Parish, I.A.4    Chen, J.H.5    Perry, C.J.6
  • 258
    • 84907459029 scopus 로고    scopus 로고
    • Enhanced antitumor immunity contributes to the radio-sensitization of Ehrlich ascites tumor by the glycolytic inhibitor 2-deoxy-D-glucose in mice
    • Farooque A, Singh N, Adhikari JS, Afrin F, Dwarakanath BS. Enhanced antitumor immunity contributes to the radio-sensitization of Ehrlich ascites tumor by the glycolytic inhibitor 2-deoxy-D-glucose in mice. PLoS One (2014) 9:e108131. doi:10.1371/journal.pone.0108131
    • (2014) PLoS One , vol.9
    • Farooque, A.1    Singh, N.2    Adhikari, J.S.3    Afrin, F.4    Dwarakanath, B.S.5
  • 259
    • 84948798898 scopus 로고    scopus 로고
    • Polarization of macrophages towards M1 phenotype by a combination of 2-deoxy-d-glucose and radiation: implications for tumor therapy
    • Farooque A, Afrin F, Adhikari JS, Dwarakanath BS. Polarization of macrophages towards M1 phenotype by a combination of 2-deoxy-d-glucose and radiation: implications for tumor therapy. Immunobiology (2016) 221:269-81. doi:10.1016/j.imbio.2015.10.009
    • (2016) Immunobiology , vol.221 , pp. 269-281
    • Farooque, A.1    Afrin, F.2    Adhikari, J.S.3    Dwarakanath, B.S.4
  • 260
    • 78649420520 scopus 로고    scopus 로고
    • Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway
    • Hubert S, Rissiek B, Klages K, Huehn J, Sparwasser T, Haag F, et al. Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway. J Exp Med (2010) 207:2561-8. doi:10.1084/jem.20091154
    • (2010) J Exp Med , vol.207 , pp. 2561-2568
    • Hubert, S.1    Rissiek, B.2    Klages, K.3    Huehn, J.4    Sparwasser, T.5    Haag, F.6
  • 261
    • 84941796489 scopus 로고    scopus 로고
    • A2aR antagonists: next generation checkpoint blockade for cancer immunotherapy
    • Leone RD, Lo YC, Powell JD. A2aR antagonists: next generation checkpoint blockade for cancer immunotherapy. Comput Struct Biotechnol J (2015) 13:265-72. doi:10.1016/j.csbj.2015.03.008
    • (2015) Comput Struct Biotechnol J , vol.13 , pp. 265-272
    • Leone, R.D.1    Lo, Y.C.2    Powell, J.D.3
  • 262
    • 57449097020 scopus 로고    scopus 로고
    • Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
    • Sonveaux P, Vegran F, Schroeder T, Wergin MC, Verrax J, Rabbani ZN, et al. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest (2008) 118:3930-42. doi:10.1172/JCI36843
    • (2008) J Clin Invest , vol.118 , pp. 3930-3942
    • Sonveaux, P.1    Vegran, F.2    Schroeder, T.3    Wergin, M.C.4    Verrax, J.5    Rabbani, Z.N.6
  • 263
    • 17144391819 scopus 로고    scopus 로고
    • Flavopiridol, an inhibitor of transcription: implications, problems and solutions
    • Blagosklonny MV. Flavopiridol, an inhibitor of transcription: implications, problems and solutions. Cell Cycle (2004) 3:1537-42. doi:10.4161/cc.3.12.1278
    • (2004) Cell Cycle , vol.3 , pp. 1537-1542
    • Blagosklonny, M.V.1
  • 264
    • 70449580319 scopus 로고    scopus 로고
    • Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization
    • Lee K, Zhang H, Qian DZ, Rey S, Liu JO, Semenza GL. Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization. Proc Natl Acad Sci U S A (2009) 106:17910-5. doi:10.1073/pnas.0909353106
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 17910-17915
    • Lee, K.1    Zhang, H.2    Qian, D.Z.3    Rey, S.4    Liu, J.O.5    Semenza, G.L.6
  • 265
    • 58149374576 scopus 로고    scopus 로고
    • Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth
    • Zhang H, Qian DZ, Tan YS, Lee K, Gao P, Ren YR, et al. Digoxin and other cardiac glycosides inhibit HIF-1alpha synthesis and block tumor growth. Proc Natl Acad Sci U S A (2008) 105:19579-86. doi:10.1073/pnas.0809763105
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 19579-19586
    • Zhang, H.1    Qian, D.Z.2    Tan, Y.S.3    Lee, K.4    Gao, P.5    Ren, Y.R.6
  • 266
    • 33846625170 scopus 로고    scopus 로고
    • Inhibition of hypoxia-induced angiogenesis by trichostatin A via suppression of HIF-1a activity in human osteosarcoma
    • Yang QC, Zeng BF, Shi ZM, Dong Y, Jiang ZM, Huang J, et al. Inhibition of hypoxia-induced angiogenesis by trichostatin A via suppression of HIF-1a activity in human osteosarcoma. J Exp Clin Cancer Res (2006) 25:593-9.
    • (2006) J Exp Clin Cancer Res , vol.25 , pp. 593-599
    • Yang, Q.C.1    Zeng, B.F.2    Shi, Z.M.3    Dong, Y.4    Jiang, Z.M.5    Huang, J.6
  • 267
    • 84886672916 scopus 로고    scopus 로고
    • Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen
    • Doedens AL, Phan AT, Stradner MH, Fujimoto JK, Nguyen JV, Yang E, et al. Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen. Nat Immunol (2013) 14:1173-82. doi:10.1038/ni.2714
    • (2013) Nat Immunol , vol.14 , pp. 1173-1182
    • Doedens, A.L.1    Phan, A.T.2    Stradner, M.H.3    Fujimoto, J.K.4    Nguyen, J.V.5    Yang, E.6
  • 268
    • 79957894276 scopus 로고    scopus 로고
    • Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases
    • Carmeliet P, Jain RK. Principles and mechanisms of vessel normalization for cancer and other angiogenic diseases. Nat Rev Drug Discov (2011) 10:417-27. doi:10.1038/nrd3455
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 417-427
    • Carmeliet, P.1    Jain, R.K.2
  • 269
    • 84860591982 scopus 로고    scopus 로고
    • Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice
    • Maione F, Capano S, Regano D, Zentilin L, Giacca M, Casanovas O, et al. Semaphorin 3A overcomes cancer hypoxia and metastatic dissemination induced by antiangiogenic treatment in mice. J Clin Invest (2012) 122:1832-48. doi:10.1172/JCI58976
    • (2012) J Clin Invest , vol.122 , pp. 1832-1848
    • Maione, F.1    Capano, S.2    Regano, D.3    Zentilin, L.4    Giacca, M.5    Casanovas, O.6
  • 270
    • 84885055994 scopus 로고    scopus 로고
    • Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
    • Sukumar M, Liu J, Ji Y, Subramanian M, Crompton JG, Yu Z, et al. Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function. J Clin Invest (2013) 123:4479-88. doi:10.1172/JCI69589
    • (2013) J Clin Invest , vol.123 , pp. 4479-4488
    • Sukumar, M.1    Liu, J.2    Ji, Y.3    Subramanian, M.4    Crompton, J.G.5    Yu, Z.6
  • 271
    • 67650096912 scopus 로고    scopus 로고
    • Enhancing CD8 T-cell memory by modulating fatty acid metabolism
    • Pearce EL, Walsh MC, Cejas PJ, Harms GM, Shen H, Wang LS, et al. Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature (2009) 460:103-7. doi:10.1038/nature08097
    • (2009) Nature , vol.460 , pp. 103-107
    • Pearce, E.L.1    Walsh, M.C.2    Cejas, P.J.3    Harms, G.M.4    Shen, H.5    Wang, L.S.6
  • 272
    • 79959764729 scopus 로고    scopus 로고
    • Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1
    • Ben Sahra I, Regazzetti C, Robert G, Laurent K, Le Marchand-Brustel Y, Auberger P, et al. Metformin, independent of AMPK, induces mTOR inhibition and cell-cycle arrest through REDD1. Cancer Res (2011) 71:4366-72. doi:10.1158/0008-5472.CAN-10-1769
    • (2011) Cancer Res , vol.71 , pp. 4366-4372
    • Ben Sahra, I.1    Regazzetti, C.2    Robert, G.3    Laurent, K.4    Le Marchand-Brustel, Y.5    Auberger, P.6
  • 273
    • 84865798995 scopus 로고    scopus 로고
    • Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC
    • Blandino G, Valerio M, Cioce M, Mori F, Casadei L, Pulito C, et al. Metformin elicits anticancer effects through the sequential modulation of DICER and c-MYC. Nat Commun (2012) 3:865. doi:10.1038/ncomms1859
    • (2012) Nat Commun , vol.3 , pp. 865
    • Blandino, G.1    Valerio, M.2    Cioce, M.3    Mori, F.4    Casadei, L.5    Pulito, C.6
  • 274
    • 84865301337 scopus 로고    scopus 로고
    • mTOR, metabolism, and the regulation of T-cell differentiation and function
    • Waickman AT, Powell JD. mTOR, metabolism, and the regulation of T-cell differentiation and function. Immunol Rev (2012) 249:43-58. doi:10.1111/j.1600-065X.2012.01152.x
    • (2012) Immunol Rev , vol.249 , pp. 43-58
    • Waickman, A.T.1    Powell, J.D.2
  • 275
    • 74649085700 scopus 로고    scopus 로고
    • The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin
    • Rao RR, Li Q, Odunsi K, Shrikant PA. The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin. Immunity (2010) 32:67-78. doi:10.1016/j.immuni.2009.10.010
    • (2010) Immunity , vol.32 , pp. 67-78
    • Rao, R.R.1    Li, Q.2    Odunsi, K.3    Shrikant, P.A.4
  • 276
    • 33749531942 scopus 로고    scopus 로고
    • Autophagy is induced in CD4+ T cells and important for the growth factor-withdrawal cell death
    • Li C, Capan E, Zhao Y, Zhao J, Stolz D, Watkins SC, et al. Autophagy is induced in CD4+ T cells and important for the growth factor-withdrawal cell death. J Immunol (2006) 177:5163-8. doi:10.4049/jimmunol.177.8.5163
    • (2006) J Immunol , vol.177 , pp. 5163-5168
    • Li, C.1    Capan, E.2    Zhao, Y.3    Zhao, J.4    Stolz, D.5    Watkins, S.C.6
  • 277
    • 24644445998 scopus 로고    scopus 로고
    • Rapamycin: an anti-cancer immunosuppressant?
    • Law BK. Rapamycin: an anti-cancer immunosuppressant? Crit Rev Oncol Hematol (2005) 56:47-60. doi:10.1016/j.critrevonc.2004.09.009
    • (2005) Crit Rev Oncol Hematol , vol.56 , pp. 47-60
    • Law, B.K.1
  • 278
    • 85002247420 scopus 로고    scopus 로고
    • The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment
    • Sharma MD, Shinde R, McGaha TL, Huang L, Holmgaard RB, Wolchok JD, et al. The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment. Sci Adv (2015) 1:e1500845. doi:10.1126/sciadv.1500845
    • (2015) Sci Adv , vol.1
    • Sharma, M.D.1    Shinde, R.2    McGaha, T.L.3    Huang, L.4    Holmgaard, R.B.5    Wolchok, J.D.6
  • 279
    • 77952215842 scopus 로고    scopus 로고
    • Quality of life in patients with advanced renal cell carcinoma treated with temsirolimus or interferon-alpha
    • Yang S, de Souza P, Alemao E, Purvis J. Quality of life in patients with advanced renal cell carcinoma treated with temsirolimus or interferon-alpha. Br J Cancer (2010) 102:1456-60. doi:10.1038/sj.bjc.6605647
    • (2010) Br J Cancer , vol.102 , pp. 1456-1460
    • Yang, S.1    de Souza, P.2    Alemao, E.3    Purvis, J.4
  • 280
    • 48649107474 scopus 로고    scopus 로고
    • Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial
    • Motzer RJ, Escudier B, Oudard S, Hutson TE, Porta C, Bracarda S, et al. Efficacy of everolimus in advanced renal cell carcinoma: a double-blind, randomised, placebo-controlled phase III trial. Lancet (2008) 372:449-56. doi:10.1016/S0140-6736(08)61039-9
    • (2008) Lancet , vol.372 , pp. 449-456
    • Motzer, R.J.1    Escudier, B.2    Oudard, S.3    Hutson, T.E.4    Porta, C.5    Bracarda, S.6
  • 281
    • 84865805718 scopus 로고    scopus 로고
    • Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment
    • Martelli AM, Chiarini F, Evangelisti C, Cappellini A, Buontempo F, Bressanin D, et al. Two hits are better than one: targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment. Oncotarget (2012) 3:371-94. doi:10.18632/oncotarget.477
    • (2012) Oncotarget , vol.3 , pp. 371-394
    • Martelli, A.M.1    Chiarini, F.2    Evangelisti, C.3    Cappellini, A.4    Buontempo, F.5    Bressanin, D.6
  • 282
    • 84969718591 scopus 로고    scopus 로고
    • Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth
    • Wang H, Wang L, Zhang Y, Wang J, Deng Y, Lin D. Inhibition of glycolytic enzyme hexokinase II (HK2) suppresses lung tumor growth. Cancer Cell Int (2016) 16:9. doi:10.1186/s12935-016-0280-y
    • (2016) Cancer Cell Int , vol.16 , pp. 9
    • Wang, H.1    Wang, L.2    Zhang, Y.3    Wang, J.4    Deng, Y.5    Lin, D.6
  • 283
  • 284
    • 0001601215 scopus 로고
    • Effects of 2-deoxyglucose on carbohydrate metablism: review of the literature and studies in the rat
    • Brown J. Effects of 2-deoxyglucose on carbohydrate metablism: review of the literature and studies in the rat. Metabolism (1962) 11:1098-112.
    • (1962) Metabolism , vol.11 , pp. 1098-1112
    • Brown, J.1
  • 286
    • 77951235938 scopus 로고    scopus 로고
    • Cytotoxicity, radiosensitization, and chemosensitization of tumor cells by 2-deoxy-D-glucose in vitro
    • Dwarakanath BS. Cytotoxicity, radiosensitization, and chemosensitization of tumor cells by 2-deoxy-D-glucose in vitro. J Cancer Res Ther (2009) 5(Suppl 1):S27-31. doi:10.4103/0973-1482.55137
    • (2009) J Cancer Res Ther , vol.5 , pp. S27-31
    • Dwarakanath, B.S.1
  • 287
    • 0030009250 scopus 로고    scopus 로고
    • Improving cancer radiotherapy with 2-deoxy-D-glucose: phase I/II clinical trials on human cerebral gliomas
    • Mohanti BK, Rath GK, Anantha N, Kannan V, Das BS, Chandramouli BA, et al. Improving cancer radiotherapy with 2-deoxy-D-glucose: phase I/II clinical trials on human cerebral gliomas. Int J Radiat Oncol Biol Phys (1996) 35:103-11. doi:10.1016/S0360-3016(96)85017-6
    • (1996) Int J Radiat Oncol Biol Phys , vol.35 , pp. 103-111
    • Mohanti, B.K.1    Rath, G.K.2    Anantha, N.3    Kannan, V.4    Das, B.S.5    Chandramouli, B.A.6
  • 288
    • 23044507635 scopus 로고    scopus 로고
    • Optimizing cancer radiotherapy with 2-deoxy-d-glucose dose escalation studies in patients with glioblastoma multiforme
    • Singh D, Banerji AK, Dwarakanath BS, Tripathi RP, Gupta JP, Mathew TL, et al. Optimizing cancer radiotherapy with 2-deoxy-d-glucose dose escalation studies in patients with glioblastoma multiforme. Strahlenther Onkol (2005) 181:507-14. doi:10.1007/s00066-005-1320-z
    • (2005) Strahlenther Onkol , vol.181 , pp. 507-514
    • Singh, D.1    Banerji, A.K.2    Dwarakanath, B.S.3    Tripathi, R.P.4    Gupta, J.P.5    Mathew, T.L.6
  • 289
    • 77951221371 scopus 로고    scopus 로고
    • Clinical studies for improving radiotherapy with 2-deoxy-D-glucose: present status and future prospects
    • Dwarakanath BS, Singh D, Banerji AK, Sarin R, Venkataramana NK, Jalali R, et al. Clinical studies for improving radiotherapy with 2-deoxy-D-glucose: present status and future prospects. J Cancer Res Ther (2009) 5(Suppl 1):S21-6. doi:10.4103/0973-1482.55136
    • (2009) J Cancer Res Ther , vol.5 , pp. S21-S26
    • Dwarakanath, B.S.1    Singh, D.2    Banerji, A.K.3    Sarin, R.4    Venkataramana, N.K.5    Jalali, R.6
  • 290
    • 84885380134 scopus 로고    scopus 로고
    • Protective effect on normal brain tissue during a combinational therapy of 2-deoxy-d-glucose and hypofractionated irradiation in malignant gliomas
    • Venkataramanaa NK, Venkatesh PK, Dwarakanath BS, Vani S. Protective effect on normal brain tissue during a combinational therapy of 2-deoxy-d-glucose and hypofractionated irradiation in malignant gliomas. Asian J Neurosurg (2013) 8:9-14. doi:10.4103/1793-5482.110274
    • (2013) Asian J Neurosurg , vol.8 , pp. 9-14
    • Venkataramanaa, N.K.1    Venkatesh, P.K.2    Dwarakanath, B.S.3    Vani, S.4
  • 291
    • 78649737749 scopus 로고    scopus 로고
    • Induction of glucose metabolism in stimulated T lymphocytes is regulated by mitogen-activated protein kinase signaling
    • Marko AJ, Miller RA, Kelman A, Frauwirth KA. Induction of glucose metabolism in stimulated T lymphocytes is regulated by mitogen-activated protein kinase signaling. PLoS One (2010) 5:e15425. doi:10.1371/journal.pone.0015425
    • (2010) PLoS One , vol.5
    • Marko, A.J.1    Miller, R.A.2    Kelman, A.3    Frauwirth, K.A.4
  • 292
    • 84878655372 scopus 로고    scopus 로고
    • Case report: sodium dichloroacetate (DCA) inhibition of the "Warburg Effect" in a human cancer patient: complete response in non-Hodgkin's lymphoma after disease progression with rituximab-CHOP
    • Strum SB, Adalsteinsson O, Black RR, Segal D, Peress NL, Waldenfels J. Case report: sodium dichloroacetate (DCA) inhibition of the "Warburg Effect" in a human cancer patient: complete response in non-Hodgkin's lymphoma after disease progression with rituximab-CHOP. J Bioenerg Biomembr (2013) 45:307-15. doi:10.1007/s10863-013-9516-x
    • (2013) J Bioenerg Biomembr , vol.45 , pp. 307-315
    • Strum, S.B.1    Adalsteinsson, O.2    Black, R.R.3    Segal, D.4    Peress, N.L.5    Waldenfels, J.6
  • 293
    • 84905187426 scopus 로고    scopus 로고
    • Regulation of the pentose phosphate pathway in cancer
    • Jiang P, Du W, Wu M. Regulation of the pentose phosphate pathway in cancer. Protein Cell (2014) 5:592-602. doi:10.1007/s13238-014-0082-8
    • (2014) Protein Cell , vol.5 , pp. 592-602
    • Jiang, P.1    Du, W.2    Wu, M.3
  • 294
    • 84906894979 scopus 로고    scopus 로고
    • Regulation of the pentose phosphate pathway by an androgen receptor-mTOR-mediated mechanism and its role in prostate cancer cell growth
    • Tsouko E, Khan AS, White MA, Han JJ, Shi Y, Merchant FA, et al. Regulation of the pentose phosphate pathway by an androgen receptor-mTOR-mediated mechanism and its role in prostate cancer cell growth. Oncogenesis (2014) 3:e103. doi:10.1038/oncsis.2014.18
    • (2014) Oncogenesis , vol.3
    • Tsouko, E.1    Khan, A.S.2    White, M.A.3    Han, J.J.4    Shi, Y.5    Merchant, F.A.6
  • 295
    • 84866361703 scopus 로고    scopus 로고
    • Radiosensitization by 2-deoxy-D-glucose and 6-aminonicotinamide involves activation of redox sensitive ASK1-JNK/p38MAPK signaling in head and neck cancer cells
    • Sharma PK, Dwarakanath BS, Varshney R. Radiosensitization by 2-deoxy-D-glucose and 6-aminonicotinamide involves activation of redox sensitive ASK1-JNK/p38MAPK signaling in head and neck cancer cells. Free Radic Biol Med (2012) 53:1500-13. doi:10.1016/j.freeradbiomed.2012.07.001
    • (2012) Free Radic Biol Med , vol.53 , pp. 1500-1513
    • Sharma, P.K.1    Dwarakanath, B.S.2    Varshney, R.3
  • 296
    • 23644437291 scopus 로고    scopus 로고
    • Radiosensitization by 6-aminonicotinamide and 2-deoxy-D-glucose in human cancer cells
    • Varshney R, Dwarakanath B, Jain V. Radiosensitization by 6-aminonicotinamide and 2-deoxy-D-glucose in human cancer cells. Int J Radiat Biol (2005) 81:397-408. doi:10.1080/09553000500148590
    • (2005) Int J Radiat Biol , vol.81 , pp. 397-408
    • Varshney, R.1    Dwarakanath, B.2    Jain, V.3
  • 297
    • 11144323811 scopus 로고    scopus 로고
    • Radiosensitization of murine Ehrlich ascites tumor by a combination of 2-deoxy-D-glucose and 6-aminonicotinamide
    • Varshney R, Gupta S, Dwarakanath BS. Radiosensitization of murine Ehrlich ascites tumor by a combination of 2-deoxy-D-glucose and 6-aminonicotinamide. Technol Cancer Res Treat (2004) 3:659-63. doi:10.1177/153303460400300616
    • (2004) Technol Cancer Res Treat , vol.3 , pp. 659-663
    • Varshney, R.1    Gupta, S.2    Dwarakanath, B.S.3
  • 298
    • 84992437322 scopus 로고    scopus 로고
    • PFK15, a small molecule inhibitor of PFKFB3, induces cell cycle arrest, apoptosis and inhibits invasion in gastric cancer
    • Zhu W, Ye L, Zhang J, Yu P, Wang H, Ye Z, et al. PFK15, a small molecule inhibitor of PFKFB3, induces cell cycle arrest, apoptosis and inhibits invasion in gastric cancer. PLoS One (2016) 11:e0163768. doi:10.1371/journal.pone.0163768
    • (2016) PLoS One , vol.11
    • Zhu, W.1    Ye, L.2    Zhang, J.3    Yu, P.4    Wang, H.5    Ye, Z.6
  • 299
    • 84976574811 scopus 로고    scopus 로고
    • In vitro and in vivo study of epigallocatechin-3-gallate-induced apoptosis in aerobic glycolytic hepatocellular carcinoma cells involving inhibition of phosphofructokinase activity
    • Li S, Wu L, Feng J, Li J, Liu T, Zhang R, et al. In vitro and in vivo study of epigallocatechin-3-gallate-induced apoptosis in aerobic glycolytic hepatocellular carcinoma cells involving inhibition of phosphofructokinase activity. Sci Rep (2016) 6:28479. doi:10.1038/srep28479
    • (2016) Sci Rep , vol.6 , pp. 28479
    • Li, S.1    Wu, L.2    Feng, J.3    Li, J.4    Liu, T.5    Zhang, R.6
  • 300
    • 84975215640 scopus 로고    scopus 로고
    • Curcumin inhibits aerobic glycolysis in hepatic stellate cells associated with activation of adenosine monophosphate-activated protein kinase
    • Lian N, Jin H, Zhang F, Wu L, Shao J, Lu Y, et al. Curcumin inhibits aerobic glycolysis in hepatic stellate cells associated with activation of adenosine monophosphate-activated protein kinase. IUBMB Life (2016) 68:589-96. doi:10.1002/iub.1518
    • (2016) IUBMB Life , vol.68 , pp. 589-596
    • Lian, N.1    Jin, H.2    Zhang, F.3    Wu, L.4    Shao, J.5    Lu, Y.6
  • 301
    • 85004144063 scopus 로고    scopus 로고
    • Inhibition of the glycolytic activator PFKFB3 in endothelium induces tumor vessel normalization, impairs metastasis, and improves chemotherapy
    • Cantelmo AR, Conradi LC, Brajic A, Goveia J, Kalucka J, Pircher A, et al. Inhibition of the glycolytic activator PFKFB3 in endothelium induces tumor vessel normalization, impairs metastasis, and improves chemotherapy. Cancer Cell (2016) 30:968-85. doi:10.1016/j.ccell.2016.10.006
    • (2016) Cancer Cell , vol.30 , pp. 968-985
    • Cantelmo, A.R.1    Conradi, L.C.2    Brajic, A.3    Goveia, J.4    Kalucka, J.5    Pircher, A.6
  • 302
    • 84901587673 scopus 로고    scopus 로고
    • Killing multiple myeloma cells with the small molecule 3-bromopyruvate: implications for therapy
    • Majkowska-Skrobek G, Augustyniak D, Lis P, Bartkowiak A, Gonchar M, Ko YH, et al. Killing multiple myeloma cells with the small molecule 3-bromopyruvate: implications for therapy. Anticancer Drugs (2014) 25:673-82. doi:10.1097/CAD.0000000000000094
    • (2014) Anticancer Drugs , vol.25 , pp. 673-682
    • Majkowska-Skrobek, G.1    Augustyniak, D.2    Lis, P.3    Bartkowiak, A.4    Gonchar, M.5    Ko, Y.H.6
  • 303
    • 85007256422 scopus 로고    scopus 로고
    • The HK2 dependent "Warburg effect" and mitochondrial oxidative phosphorylation in cancer: targets for effective therapy with 3-bromopyruvate
    • Lis P, Dylag M, Niedzwiecka K, Ko YH, Pedersen PL, Goffeau A, et al. The HK2 dependent "Warburg effect" and mitochondrial oxidative phosphorylation in cancer: targets for effective therapy with 3-bromopyruvate. Molecules (2016) 21:E1730. doi:10.3390/molecules21121730
    • (2016) Molecules , vol.21 , pp. E1730
    • Lis, P.1    Dylag, M.2    Niedzwiecka, K.3    Ko, Y.H.4    Pedersen, P.L.5    Goffeau, A.6
  • 304
    • 84883514161 scopus 로고    scopus 로고
    • Targeting lactate metabolism for cancer therapeutics
    • Doherty JR, Cleveland JL. Targeting lactate metabolism for cancer therapeutics. J Clin Invest (2013) 123:3685-92. doi:10.1172/JCI69741
    • (2013) J Clin Invest , vol.123 , pp. 3685-3692
    • Doherty, J.R.1    Cleveland, J.L.2
  • 305
    • 0142058027 scopus 로고    scopus 로고
    • Addition of either lonidamine or granulocyte colony-stimulating factor does not improve survival in early breast cancer patients treated with high-dose epirubicin and cyclophosphamide
    • Papaldo P, Lopez M, Cortesi E, Cammilluzzi E, Antimi M, Terzoli E, et al. Addition of either lonidamine or granulocyte colony-stimulating factor does not improve survival in early breast cancer patients treated with high-dose epirubicin and cyclophosphamide. J Clin Oncol (2003) 21:3462-8. doi:10.1200/JCO.2003.03.034
    • (2003) J Clin Oncol , vol.21 , pp. 3462-3468
    • Papaldo, P.1    Lopez, M.2    Cortesi, E.3    Cammilluzzi, E.4    Antimi, M.5    Terzoli, E.6
  • 306
    • 0037368877 scopus 로고    scopus 로고
    • Lonidamine: efficacy and safety in clinical trials for the treatment of solid tumors
    • Di Cosimo S, Ferretti G, Papaldo P, Carlini P, Fabi A, Cognetti F. Lonidamine: efficacy and safety in clinical trials for the treatment of solid tumors. Drugs Today (Barc) (2003) 39:157-74. doi:10.1358/dot.2003.39.3.799451
    • (2003) Drugs Today (Barc) , vol.39 , pp. 157-174
    • Di Cosimo, S.1    Ferretti, G.2    Papaldo, P.3    Carlini, P.4    Fabi, A.5    Cognetti, F.6
  • 307
    • 33751091519 scopus 로고    scopus 로고
    • The H+-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for high-risk neuroblastoma
    • Fang J, Quinones QJ, Holman TL, Morowitz MJ, Wang Q, Zhao H, et al. The H+-linked monocarboxylate transporter (MCT1/SLC16A1): a potential therapeutic target for high-risk neuroblastoma. Mol Pharmacol (2006) 70:2108-15. doi:10.1124/mol.106.026245
    • (2006) Mol Pharmacol , vol.70 , pp. 2108-2115
    • Fang, J.1    Quinones, Q.J.2    Holman, T.L.3    Morowitz, M.J.4    Wang, Q.5    Zhao, H.6
  • 308
    • 85007578604 scopus 로고    scopus 로고
    • Metabolic reprogramming and AMPKalpha1 pathway activation by caulerpin in colorectal cancer cells
    • Yu H, Zhang H, Dong M, Wu Z, Shen Z, Xie Y, et al. Metabolic reprogramming and AMPKalpha1 pathway activation by caulerpin in colorectal cancer cells. Int J Oncol (2017) 50:161-72. doi:10.3892/ijo.2016.3794
    • (2017) Int J Oncol , vol.50 , pp. 161-172
    • Yu, H.1    Zhang, H.2    Dong, M.3    Wu, Z.4    Shen, Z.5    Xie, Y.6
  • 309
    • 80054694464 scopus 로고    scopus 로고
    • Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells
    • Molon B, Ugel S, Del Pozzo F, Soldani C, Zilio S, Avella D, et al. Chemokine nitration prevents intratumoral infiltration of antigen-specific T cells. J Exp Med (2011) 208:1949-62. doi:10.1084/jem.20101956
    • (2011) J Exp Med , vol.208 , pp. 1949-1962
    • Molon, B.1    Ugel, S.2    Del Pozzo, F.3    Soldani, C.4    Zilio, S.5    Avella, D.6
  • 310
    • 16244408626 scopus 로고    scopus 로고
    • Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy
    • Muller AJ, DuHadaway JB, Donover PS, Sutanto-Ward E, Prendergast GC. Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy. Nat Med (2005) 11:312-9. doi:10.1038/nm1196
    • (2005) Nat Med , vol.11 , pp. 312-319
    • Muller, A.J.1    DuHadaway, J.B.2    Donover, P.S.3    Sutanto-Ward, E.4    Prendergast, G.C.5
  • 311
    • 77951718214 scopus 로고    scopus 로고
    • Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity
    • Liu X, Shin N, Koblish HK, Yang G, Wang Q, Wang K, et al. Selective inhibition of IDO1 effectively regulates mediators of antitumor immunity. Blood (2010) 115:3520-30. doi:10.1182/blood-2009-09-246124
    • (2010) Blood , vol.115 , pp. 3520-3530
    • Liu, X.1    Shin, N.2    Koblish, H.K.3    Yang, G.4    Wang, Q.5    Wang, K.6
  • 312
    • 80052493233 scopus 로고    scopus 로고
    • Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido
    • Balachandran VP, Cavnar MJ, Zeng S, Bamboat ZM, Ocuin LM, Obaid H, et al. Imatinib potentiates antitumor T cell responses in gastrointestinal stromal tumor through the inhibition of Ido. Nat Med (2011) 17:1094-100. doi:10.1038/nm.2438
    • (2011) Nat Med , vol.17 , pp. 1094-1100
    • Balachandran, V.P.1    Cavnar, M.J.2    Zeng, S.3    Bamboat, Z.M.4    Ocuin, L.M.5    Obaid, H.6
  • 313
    • 3843119865 scopus 로고    scopus 로고
    • Imatinib mesylate inhibits T-cell proliferation in vitro and delayed-type hypersensitivity in vivo
    • Dietz AB, Souan L, Knutson GJ, Bulur PA, Litzow MR, Vuk-Pavlovic S. Imatinib mesylate inhibits T-cell proliferation in vitro and delayed-type hypersensitivity in vivo. Blood (2004) 104:1094-9. doi:10.1182/blood-2003-12-4266
    • (2004) Blood , vol.104 , pp. 1094-1099
    • Dietz, A.B.1    Souan, L.2    Knutson, G.J.3    Bulur, P.A.4    Litzow, M.R.5    Vuk-Pavlovic, S.6
  • 314
    • 77953911933 scopus 로고    scopus 로고
    • Constitutively active Lck kinase in T cells drives antigen receptor signal transduction
    • Nika K, Soldani C, Salek M, Paster W, Gray A, Etzensperger R, et al. Constitutively active Lck kinase in T cells drives antigen receptor signal transduction. Immunity (2010) 32:766-77. doi:10.1016/j.immuni.2010.05.011
    • (2010) Immunity , vol.32 , pp. 766-777
    • Nika, K.1    Soldani, C.2    Salek, M.3    Paster, W.4    Gray, A.5    Etzensperger, R.6
  • 315
    • 84991049612 scopus 로고    scopus 로고
    • An indispensable role of CPT-1a to survive cancer cells during energy stress through rewiring cancer metabolism
    • Luo J, Hong Y, Tao X, Wei X, Zhang L, Li Q. An indispensable role of CPT-1a to survive cancer cells during energy stress through rewiring cancer metabolism. Tumour Biol (2016) 37:15795-804. doi:10.1007/s13277-016-5382-6
    • (2016) Tumour Biol , vol.37 , pp. 15795-15804
    • Luo, J.1    Hong, Y.2    Tao, X.3    Wei, X.4    Zhang, L.5    Li, Q.6
  • 316
    • 84993177195 scopus 로고    scopus 로고
    • Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer
    • Qian J, Chen Y, Meng T, Ma L, Meng L, Wang X, et al. Molecular regulation of apoptotic machinery and lipid metabolism by mTORC1/mTORC2 dual inhibitors in preclinical models of HER2+/PIK3CAmut breast cancer. Oncotarget (2016) 7(41):67071-86. doi:10.18632/oncotarget.11490
    • (2016) Oncotarget , vol.7 , Issue.41 , pp. 67071-67086
    • Qian, J.1    Chen, Y.2    Meng, T.3    Ma, L.4    Meng, L.5    Wang, X.6
  • 317
    • 84881192927 scopus 로고    scopus 로고
    • mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function
    • Zeng H, Yang K, Cloer C, Neale G, Vogel P, Chi H. mTORC1 couples immune signals and metabolic programming to establish T(reg)-cell function. Nature (2013) 499:485-90. doi:10.1038/nature12297
    • (2013) Nature , vol.499 , pp. 485-490
    • Zeng, H.1    Yang, K.2    Cloer, C.3    Neale, G.4    Vogel, P.5    Chi, H.6
  • 318
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor
    • Tontonoz P, Hu E, Spiegelman BM. Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell (1994) 79:1147-56. doi:10.1016/0092-8674(94)90006-X
    • (1994) Cell , vol.79 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.2    Spiegelman, B.M.3
  • 319
    • 0033616795 scopus 로고    scopus 로고
    • Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma
    • Demetri GD, Fletcher CD, Mueller E, Sarraf P, Naujoks R, Campbell N, et al. Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma. Proc Natl Acad Sci U S A (1999) 96:3951-6. doi:10.1073/pnas.96.7.3951
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 3951-3956
    • Demetri, G.D.1    Fletcher, C.D.2    Mueller, E.3    Sarraf, P.4    Naujoks, R.5    Campbell, N.6
  • 320
    • 84905017618 scopus 로고    scopus 로고
    • Metformin limits the adipocyte tumor-promoting effect on ovarian cancer
    • Tebbe C, Chhina J, Dar SA, Sarigiannis K, Giri S, Munkarah AR, et al. Metformin limits the adipocyte tumor-promoting effect on ovarian cancer. Oncotarget (2014) 5:4746-64. doi:10.18632/oncotarget.2012
    • (2014) Oncotarget , vol.5 , pp. 4746-4764
    • Tebbe, C.1    Chhina, J.2    Dar, S.A.3    Sarigiannis, K.4    Giri, S.5    Munkarah, A.R.6
  • 321
    • 77954162846 scopus 로고    scopus 로고
    • Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: a new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells
    • Martinez-Outschoorn UE, Balliet RM, Rivadeneira DB, Chiavarina B, Pavlides S, Wang C, et al. Oxidative stress in cancer associated fibroblasts drives tumor-stroma co-evolution: a new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells. Cell Cycle (2010) 9:3256-76. doi:10.4161/cc.9.16.12553
    • (2010) Cell Cycle , vol.9 , pp. 3256-3276
    • Martinez-Outschoorn, U.E.1    Balliet, R.M.2    Rivadeneira, D.B.3    Chiavarina, B.4    Pavlides, S.5    Wang, C.6
  • 325
    • 0036721563 scopus 로고    scopus 로고
    • Modulation of growth and radiochemosensitivity of human malignant glioma cells by acidosis
    • Reichert M, Steinbach JP, Supra P, Weller M. Modulation of growth and radiochemosensitivity of human malignant glioma cells by acidosis. Cancer (2002) 95:1113-9. doi:10.1002/cncr.10767
    • (2002) Cancer , vol.95 , pp. 1113-1119
    • Reichert, M.1    Steinbach, J.P.2    Supra, P.3    Weller, M.4
  • 326
    • 33745110220 scopus 로고    scopus 로고
    • Tumor pH controls the in vivo efficacy of weak acid and base chemotherapeutics
    • Gerweck LE, Vijayappa S, Kozin S. Tumor pH controls the in vivo efficacy of weak acid and base chemotherapeutics. Mol Cancer Ther (2006) 5:1275-9. doi:10.1158/1535-7163.MCT-06-0024
    • (2006) Mol Cancer Ther , vol.5 , pp. 1275-1279
    • Gerweck, L.E.1    Vijayappa, S.2    Kozin, S.3
  • 327
    • 52449104060 scopus 로고    scopus 로고
    • The proton pump inhibitor inhibits cell growth and induces apoptosis in human hepatoblastoma
    • Morimura T, Fujita K, Akita M, Nagashima M, Satomi A. The proton pump inhibitor inhibits cell growth and induces apoptosis in human hepatoblastoma. Pediatr Surg Int (2008) 24:1087-94. doi:10.1007/s00383-008-2229-2
    • (2008) Pediatr Surg Int , vol.24 , pp. 1087-1094
    • Morimura, T.1    Fujita, K.2    Akita, M.3    Nagashima, M.4    Satomi, A.5
  • 328
    • 84872288221 scopus 로고    scopus 로고
    • Mode of cell death induction by pharmacological vacuolar H+-ATPase (V-ATPase) inhibition
    • von Schwarzenberg K, Wiedmann RM, Oak P, Schulz S, Zischka H, Wanner G, et al. Mode of cell death induction by pharmacological vacuolar H+-ATPase (V-ATPase) inhibition. J Biol Chem (2013) 288:1385-96. doi:10.1074/jbc.M112.412007
    • (2013) J Biol Chem , vol.288 , pp. 1385-1396
    • von Schwarzenberg, K.1    Wiedmann, R.M.2    Oak, P.3    Schulz, S.4    Zischka, H.5    Wanner, G.6
  • 330
    • 33846562017 scopus 로고    scopus 로고
    • Extracellular acidosis elevates carbonic anhydrase IX in human glioblastoma cells via transcriptional modulation that does not depend on hypoxia
    • Ihnatko R, Kubes M, Takacova M, Sedlakova O, Sedlak J, Pastorek J, et al. Extracellular acidosis elevates carbonic anhydrase IX in human glioblastoma cells via transcriptional modulation that does not depend on hypoxia. Int J Oncol (2006) 29:1025-33. doi:10.3892/ijo.29.4.1025
    • (2006) Int J Oncol , vol.29 , pp. 1025-1033
    • Ihnatko, R.1    Kubes, M.2    Takacova, M.3    Sedlakova, O.4    Sedlak, J.5    Pastorek, J.6
  • 331
    • 44449116191 scopus 로고    scopus 로고
    • Development of small molecule carbonic anhydrase IX inhibitors
    • Supuran CT. Development of small molecule carbonic anhydrase IX inhibitors. BJU Int (2008) 101(Suppl 4):39-40. doi:10.1111/j.1464-410X.2008.07648.x
    • (2008) BJU Int , vol.101 , pp. 39-40
    • Supuran, C.T.1
  • 332
    • 79955490807 scopus 로고    scopus 로고
    • Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors
    • Lou Y, McDonald PC, Oloumi A, Chia S, Ostlund C, Ahmadi A, et al. Targeting tumor hypoxia: suppression of breast tumor growth and metastasis by novel carbonic anhydrase IX inhibitors. Cancer Res (2011) 71:3364-76. doi:10.1158/0008-5472.CAN-10-4261
    • (2011) Cancer Res , vol.71 , pp. 3364-3376
    • Lou, Y.1    McDonald, P.C.2    Oloumi, A.3    Chia, S.4    Ostlund, C.5    Ahmadi, A.6
  • 333
    • 84891683141 scopus 로고    scopus 로고
    • Acidic tumor microenvironment and pH-sensing G protein-coupled receptors
    • Justus CR, Dong L, Yang LV. Acidic tumor microenvironment and pH-sensing G protein-coupled receptors. Front Physiol (2013) 4:354. doi:10.3389/fphys.2013.00354
    • (2013) Front Physiol , vol.4 , pp. 354
    • Justus, C.R.1    Dong, L.2    Yang, L.V.3
  • 334
    • 84994680371 scopus 로고    scopus 로고
    • Targeting stromal glutamine synthetase in tumors disrupts tumor microenvironment-regulated cancer cell growth
    • Yang L, Achreja A, Yeung TL, Mangala LS, Jiang D, Han C, et al. Targeting stromal glutamine synthetase in tumors disrupts tumor microenvironment-regulated cancer cell growth. Cell Metab (2016) 24:685-700. doi:10.1016/j.cmet.2016.10.011
    • (2016) Cell Metab , vol.24 , pp. 685-700
    • Yang, L.1    Achreja, A.2    Yeung, T.L.3    Mangala, L.S.4    Jiang, D.5    Han, C.6
  • 335
    • 84940063528 scopus 로고    scopus 로고
    • Chronic dietary administration of the glycolytic inhibitor 2-Deoxy-D-Glucose (2-DG) inhibits the growth of implanted Ehrlich's ascites tumor in mice
    • Singh S, Pandey S, Bhatt AN, Chaudhary R, Bhuria V, Kalra N, et al. Chronic dietary administration of the glycolytic inhibitor 2-Deoxy-D-Glucose (2-DG) inhibits the growth of implanted Ehrlich's ascites tumor in mice. PLoS One (2015) 10:e0132089. doi:10.1371/journal.pone.0132089
    • (2015) PLoS One , vol.10
    • Singh, S.1    Pandey, S.2    Bhatt, A.N.3    Chaudhary, R.4    Bhuria, V.5    Kalra, N.6
  • 336
    • 84970028297 scopus 로고    scopus 로고
    • Immunometabolism of regulatory T cells
    • Newton R, Priyadharshini B, Turka LA. Immunometabolism of regulatory T cells. Nat Immunol (2016) 17:618-25. doi:10.1038/ni.3466
    • (2016) Nat Immunol , vol.17 , pp. 618-625
    • Newton, R.1    Priyadharshini, B.2    Turka, L.A.3
  • 337
    • 84942982260 scopus 로고    scopus 로고
    • Metabolic reprogramming in macrophages and dendritic cells in innate immunity
    • Kelly B, O'Neill LA. Metabolic reprogramming in macrophages and dendritic cells in innate immunity. Cell Res (2015) 25:771-84. doi:10.1038/cr.2015.68
    • (2015) Cell Res , vol.25 , pp. 771-784
    • Kelly, B.1    O'Neill, L.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.