메뉴 건너뛰기




Volumn 5, Issue 8, 2014, Pages 592-602

Regulation of the pentose phosphate pathway in cancer

Author keywords

cancer; cell proliferation; G6PD; glucose metabolism; NADPH; pentose phosphate pathway (PPP)

Indexed keywords

DOXORUBICIN; FLUOROURACIL; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; GLYCERALDEHYDE 3 PHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MALATE DEHYDROGENASE (DECARBOXYLATING); MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3, 4, 5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P53; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RIBOSE 5 PHOSPHATE; STEROL REGULATORY ELEMENT BINDING PROTEIN; UNCLASSIFIED DRUG; GLUCOSE;

EID: 84905187426     PISSN: 1674800X     EISSN: 16748018     Source Type: Journal    
DOI: 10.1007/s13238-014-0082-8     Document Type: Article
Times cited : (398)

References (89)
  • 3
    • 28844448182 scopus 로고    scopus 로고
    • Oncogenic PI3K deregulates transcription and translation
    • Bader AG, Kang S, Zhao L, Vogt PK (2005) Oncogenic PI3K deregulates transcription and translation. Nat Rev Cancer 5: 921-929.
    • (2005) Nat Rev Cancer , vol.5 , pp. 921-929
    • Bader, A.G.1    Kang, S.2    Zhao, L.3    Vogt, P.K.4
  • 7
    • 0033852872 scopus 로고    scopus 로고
    • Mutations of the human PTEN gene
    • Bonneau D, Longy M (2000) Mutations of the human PTEN gene. Hum Mutat 16: 109-122.
    • (2000) Hum Mutat , vol.16 , pp. 109-122
    • Bonneau, D.1    Longy, M.2
  • 9
    • 84901244771 scopus 로고    scopus 로고
    • How the TP53 family proteins TP63 and TP73 contribute to tumorigenesis: regulators and effectors
    • Candi E, Agostini M, Melino G, Bernassola F (2014) How the TP53 family proteins TP63 and TP73 contribute to tumorigenesis: regulators and effectors. Hum Mutat 35: 702-714.
    • (2014) Hum Mutat , vol.35 , pp. 702-714
    • Candi, E.1    Agostini, M.2    Melino, G.3    Bernassola, F.4
  • 10
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley LC (2002) The phosphoinositide 3-kinase pathway. Science 296: 1655-1657.
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 11
    • 0033551070 scopus 로고    scopus 로고
    • New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway
    • Cantley LC, Neel BG (1999) New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci USA 96: 4240-4245.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 4240-4245
    • Cantley, L.C.1    Neel, B.G.2
  • 14
    • 79551580561 scopus 로고    scopus 로고
    • ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair
    • Cosentino C, Grieco D, Costanzo V (2011) ATM activates the pentose phosphate pathway promoting anti-oxidant defence and DNA repair. EMBO J 30: 546-555.
    • (2011) EMBO J , vol.30 , pp. 546-555
    • Cosentino, C.1    Grieco, D.2    Costanzo, V.3
  • 16
    • 33645319245 scopus 로고    scopus 로고
    • Extracellular nucleotides and adenosine independently activate AMP-activated protein kinase in endothelial cells: involvement of P2 receptors and adenosine transporters
    • da Silva CG, Jarzyna R, Specht A, Kaczmarek E (2006) Extracellular nucleotides and adenosine independently activate AMP-activated protein kinase in endothelial cells: involvement of P2 receptors and adenosine transporters. Circ Res 98: e39-e47.
    • (2006) Circ Res , vol.98
    • da Silva, C.G.1    Jarzyna, R.2    Specht, A.3    Kaczmarek, E.4
  • 17
    • 84859171807 scopus 로고    scopus 로고
    • MYC on the path to cancer
    • Dang CV (2012) MYC on the path to cancer. Cell 149: 22-35.
    • (2012) Cell , vol.149 , pp. 22-35
    • Dang, C.V.1
  • 19
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB (2008) The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 7: 11-20.
    • (2008) Cell Metab , vol.7 , pp. 11-20
    • DeBerardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 22
    • 67749122122 scopus 로고    scopus 로고
    • Targeting PI3K signalling in cancer: opportunities, challenges and limitations
    • Engelman JA (2009) Targeting PI3K signalling in cancer: opportunities, challenges and limitations. Nat Rev Cancer 9: 550-562.
    • (2009) Nat Rev Cancer , vol.9 , pp. 550-562
    • Engelman, J.A.1
  • 23
    • 33746257209 scopus 로고    scopus 로고
    • The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
    • Engelman JA, Luo J, Cantley LC (2006) The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nat Rev Genet 7: 606-619.
    • (2006) Nat Rev Genet , vol.7 , pp. 606-619
    • Engelman, J.A.1    Luo, J.2    Cantley, L.C.3
  • 25
    • 84881414434 scopus 로고    scopus 로고
    • p73 keeps metabolic control in the family
    • Fets L, Anastasiou D (2013) p73 keeps metabolic control in the family. Nat Cell Biol 15: 891-893.
    • (2013) Nat Cell Biol , vol.15 , pp. 891-893
    • Fets, L.1    Anastasiou, D.2
  • 30
    • 52649107626 scopus 로고    scopus 로고
    • Cancer cell metabolism: Warburg and beyond
    • Hsu PP, Sabatini DM (2008) Cancer cell metabolism: Warburg and beyond. Cell 134: 703-707.
    • (2008) Cell , vol.134 , pp. 703-707
    • Hsu, P.P.1    Sabatini, D.M.2
  • 31
    • 77952212178 scopus 로고    scopus 로고
    • Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function
    • Hu W, Zhang C, Wu R, Sun Y, Levine A, Feng Z (2010) Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proc Natl Acad Sci USA 107: 7455-7460.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 7455-7460
    • Hu, W.1    Zhang, C.2    Wu, R.3    Sun, Y.4    Levine, A.5    Feng, Z.6
  • 32
    • 84877140107 scopus 로고    scopus 로고
    • A proposed role for glutamine in cancer cell growth through acid resistance
    • Huang W, Choi W, Chen Y, Zhang Q, Deng H, He W, Shi Y (2013) A proposed role for glutamine in cancer cell growth through acid resistance. Cell Res 23: 724-727.
    • (2013) Cell Res , vol.23 , pp. 724-727
    • Huang, W.1    Choi, W.2    Chen, Y.3    Zhang, Q.4    Deng, H.5    He, W.6    Shi, Y.7
  • 33
    • 79952280229 scopus 로고    scopus 로고
    • p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase
    • Jiang P, Du W, Wang X, Mancuso A, Gao X, Wu M, Yang X (2011) p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nat Cell Biol 13: 310-316.
    • (2011) Nat Cell Biol , vol.13 , pp. 310-316
    • Jiang, P.1    Du, W.2    Wang, X.3    Mancuso, A.4    Gao, X.5    Wu, M.6    Yang, X.7
  • 34
    • 84873678601 scopus 로고    scopus 로고
    • Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence
    • Jiang P, Du W, Mancuso A, Wellen KE, Yang X (2013a) Reciprocal regulation of p53 and malic enzymes modulates metabolism and senescence. Nature 493: 689-693.
    • (2013) Nature , vol.493 , pp. 689-693
    • Jiang, P.1    Du, W.2    Mancuso, A.3    Wellen, K.E.4    Yang, X.5
  • 35
    • 84891886652 scopus 로고    scopus 로고
    • A critical role of glucose-6-phosphate dehydrogenase in TAp73-mediated cell proliferation
    • Jiang P, Du W, Yang X (2013b) A critical role of glucose-6-phosphate dehydrogenase in TAp73-mediated cell proliferation. Cell Cycle 12: 3720-3726.
    • (2013) Cell Cycle , vol.12 , pp. 3720-3726
    • Jiang, P.1    Du, W.2    Yang, X.3
  • 36
    • 84893117261 scopus 로고    scopus 로고
    • p53 and regulation of tumor metabolism
    • Jiang P, Du W, Yang X (2013c) p53 and regulation of tumor metabolism. J Carcinog 12: 21.
    • (2013) J Carcinog , vol.12 , pp. 21
    • Jiang, P.1    Du, W.2    Yang, X.3
  • 37
    • 84857992195 scopus 로고    scopus 로고
    • Targeting cancer metabolism-aiming at a tumour's sweet-spot
    • Jones NP, Schulze A (2012) Targeting cancer metabolism-aiming at a tumour's sweet-spot. Drug Discov Today 17: 232-241.
    • (2012) Drug Discov Today , vol.17 , pp. 232-241
    • Jones, N.P.1    Schulze, A.2
  • 39
    • 0028176627 scopus 로고
    • Glucose-6-phosphate dehydrogenase: a "housekeeping" enzyme subject to tissue-specific regulation by hormones, nutrients, and oxidant stress
    • Kletzien RF, Harris PK, Foellmi LA (1994) Glucose-6-phosphate dehydrogenase: a "housekeeping" enzyme subject to tissue-specific regulation by hormones, nutrients, and oxidant stress. FASEB J 8: 174-181.
    • (1994) FASEB J , vol.8 , pp. 174-181
    • Kletzien, R.F.1    Harris, P.K.2    Foellmi, L.A.3
  • 40
    • 68949154433 scopus 로고    scopus 로고
    • A role for AMPK in the inhibition of glucose-6-phosphate dehydrogenase by polyunsaturated fatty acids
    • Kohan AB, Talukdar I, Walsh CM, Salati LM (2009) A role for AMPK in the inhibition of glucose-6-phosphate dehydrogenase by polyunsaturated fatty acids. Biochem Biophys Res Commun 388: 117-121.
    • (2009) Biochem Biophys Res Commun , vol.388 , pp. 117-121
    • Kohan, A.B.1    Talukdar, I.2    Walsh, C.M.3    Salati, L.M.4
  • 42
    • 79955398591 scopus 로고    scopus 로고
    • Otto Warburg's contributions to current concepts of cancer metabolism
    • Koppenol WH, Bounds PL, Dang CV (2011) Otto Warburg's contributions to current concepts of cancer metabolism. Nat Rev Cancer 11: 325-337.
    • (2011) Nat Rev Cancer , vol.11 , pp. 325-337
    • Koppenol, W.H.1    Bounds, P.L.2    Dang, C.V.3
  • 43
    • 44449147036 scopus 로고    scopus 로고
    • Tumor cell metabolism: cancer's Achilles' heel
    • Kroemer G, Pouyssegur J (2008) Tumor cell metabolism: cancer's Achilles' heel. Cancer Cell 13: 472-482.
    • (2008) Cancer Cell , vol.13 , pp. 472-482
    • Kroemer, G.1    Pouyssegur, J.2
  • 44
    • 0034107704 scopus 로고    scopus 로고
    • Human glucose-6-phosphate dehydrogenase (G6PD) gene transforms NIH 3T3 cells and induces tumors in nude mice
    • Kuo W, Lin J, Tang TK (2000) Human glucose-6-phosphate dehydrogenase (G6PD) gene transforms NIH 3T3 cells and induces tumors in nude mice. Int J Cancer 85: 857-864.
    • (2000) Int J Cancer , vol.85 , pp. 857-864
    • Kuo, W.1    Lin, J.2    Tang, T.K.3
  • 47
    • 84873680521 scopus 로고    scopus 로고
    • The regulation of cellular metabolism by tumor suppressor p53
    • Liang Y, Liu J, Feng Z (2013) The regulation of cellular metabolism by tumor suppressor p53. Cell Biosci 3: 9.
    • (2013) Cell Biosci , vol.3 , pp. 9
    • Liang, Y.1    Liu, J.2    Feng, Z.3
  • 49
    • 80054046029 scopus 로고    scopus 로고
    • Aerobic glycolysis: meeting the metabolic requirements of cell proliferation
    • Lunt SY, Vander Heiden MG (2011) Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu Rev Cell Dev Biol 27: 441-464.
    • (2011) Annu Rev Cell Dev Biol , vol.27 , pp. 441-464
    • Lunt, S.Y.1    Vander Heiden, M.G.2
  • 50
    • 0032577699 scopus 로고    scopus 로고
    • The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate
    • Maehama T, Dixon JE (1998) The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3, 4, 5-trisphosphate. J Biol Chem 273: 13375-13378.
    • (1998) J Biol Chem , vol.273 , pp. 13375-13378
    • Maehama, T.1    Dixon, J.E.2
  • 52
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: navigating downstream
    • Manning BD, Cantley LC (2007) AKT/PKB signaling: navigating downstream. Cell 129: 1261-1274.
    • (2007) Cell , vol.129 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 59
    • 21544469973 scopus 로고    scopus 로고
    • Estradiol-mediated endothelial nitric oxide synthase association with heat shock protein 90 requires adenosine monophosphate-dependent protein kinase
    • Schulz E, Anter E, Zou MH, Keaney JF Jr (2005) Estradiol-mediated endothelial nitric oxide synthase association with heat shock protein 90 requires adenosine monophosphate-dependent protein kinase. Circulation 111: 3473-3480.
    • (2005) Circulation , vol.111 , pp. 3473-3480
    • Schulz, E.1    Anter, E.2    Zou, M.H.3    Keaney Jr., J.F.4
  • 60
    • 1942506067 scopus 로고    scopus 로고
    • The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression
    • Schwartzenberg-Bar-Yoseph F, Armoni M, Karnieli E (2004) The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression. Cancer Res 64: 2627-2633.
    • (2004) Cancer Res , vol.64 , pp. 2627-2633
    • Schwartzenberg-Bar-Yoseph, F.1    Armoni, M.2    Karnieli, E.3
  • 61
    • 33745307617 scopus 로고    scopus 로고
    • Ras, PI(3)K and mTOR signalling controls tumour cell growth
    • Shaw RJ, Cantley LC (2006) Ras, PI(3)K and mTOR signalling controls tumour cell growth. Nature 441: 424-430.
    • (2006) Nature , vol.441 , pp. 424-430
    • Shaw, R.J.1    Cantley, L.C.2
  • 62
    • 84863244013 scopus 로고    scopus 로고
    • The fundamental role of the p53 pathway in tumor metabolism and its implication in tumor therapy
    • Shen L, Sun X, Fu Z, Yang G, Li J, Yao L (2012) The fundamental role of the p53 pathway in tumor metabolism and its implication in tumor therapy. Clin Cancer Res 18: 1561-1567.
    • (2012) Clin Cancer Res , vol.18 , pp. 1561-1567
    • Shen, L.1    Sun, X.2    Fu, Z.3    Yang, G.4    Li, J.5    Yao, L.6
  • 63
    • 0035835824 scopus 로고    scopus 로고
    • PTEN: life as a tumor suppressor
    • Simpson L, Parsons R (2001) PTEN: life as a tumor suppressor. Exp Cell Res 264: 29-41.
    • (2001) Exp Cell Res , vol.264 , pp. 29-41
    • Simpson, L.1    Parsons, R.2
  • 65
    • 84859787172 scopus 로고    scopus 로고
    • Glucose-6-phosphate dehydrogenase, NADPH, and cell survival
    • Stanton RC (2012) Glucose-6-phosphate dehydrogenase, NADPH, and cell survival. IUBMB Life 64: 362-369.
    • (2012) IUBMB Life , vol.64 , pp. 362-369
    • Stanton, R.C.1
  • 68
    • 33845707278 scopus 로고    scopus 로고
    • Statins activate AMP-activated protein kinase in vitro and in vivo
    • Sun W, Lee TS, Zhu M, Gu C, Wang Y, Zhu Y, Shyy JY (2006) Statins activate AMP-activated protein kinase in vitro and in vivo. Circulation 114: 2655-2662.
    • (2006) Circulation , vol.114 , pp. 2655-2662
    • Sun, W.1    Lee, T.S.2    Zhu, M.3    Gu, C.4    Wang, Y.5    Zhu, Y.6    Shyy, J.Y.7
  • 71
    • 33847080728 scopus 로고    scopus 로고
    • AMP-activated protein kinase in metabolic control and insulin signaling
    • Towler MC, Hardie DG (2007) AMP-activated protein kinase in metabolic control and insulin signaling. Circ Res 100: 328-341.
    • (2007) Circ Res , vol.100 , pp. 328-341
    • Towler, M.C.1    Hardie, D.G.2
  • 72
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: the metabolic requirements of cell proliferation
    • Vander Heiden MG, Cantley LC, Thompson CB (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324: 1029-1033.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 73
    • 23644437291 scopus 로고    scopus 로고
    • Radiosensitization by 6-aminonicotinamide and 2-deoxy-d-glucose in human cancer cells
    • Varshney R, Dwarakanath B, Jain V (2005) Radiosensitization by 6-aminonicotinamide and 2-deoxy-d-glucose in human cancer cells. Int J Radiat Biol 81: 397-408.
    • (2005) Int J Radiat Biol , vol.81 , pp. 397-408
    • Varshney, R.1    Dwarakanath, B.2    Jain, V.3
  • 74
    • 0032511090 scopus 로고    scopus 로고
    • Insulin regulation of glucose-6-phosphate dehydrogenase gene expression is rapamycin-sensitive and requires phosphatidylinositol 3-kinase
    • Wagle A, Jivraj S, Garlock GL, Stapleton SR (1998) Insulin regulation of glucose-6-phosphate dehydrogenase gene expression is rapamycin-sensitive and requires phosphatidylinositol 3-kinase. J Biol Chem 273: 14968-14974.
    • (1998) J Biol Chem , vol.273 , pp. 14968-14974
    • Wagle, A.1    Jivraj, S.2    Garlock, G.L.3    Stapleton, S.R.4
  • 75
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O (1956) On the origin of cancer cells. Science 123: 309-314.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 76
    • 0000459772 scopus 로고
    • Ueber den Stoffwechsel der Tumoren
    • Warburg O, Posener K, Negelein E (1924) Ueber den Stoffwechsel der Tumoren. Biochem Z 152: 319-344.
    • (1924) Biochem Z , vol.152 , pp. 319-344
    • Warburg, O.1    Posener, K.2    Negelein, E.3
  • 77
  • 80
    • 0022803107 scopus 로고
    • Physiological functions of the pentose phosphate pathway
    • Wood T (1986) Physiological functions of the pentose phosphate pathway. Cell Biochem Funct 4: 241-247.
    • (1986) Cell Biochem Funct , vol.4 , pp. 241-247
    • Wood, T.1
  • 81
    • 26844519964 scopus 로고    scopus 로고
    • Diabetes causes inhibition of glucose-6-phosphate dehydrogenase via activation of PKA, which contributes to oxidative stress in rat kidney cortex
    • Xu Y, Osborne BW, Stanton RC (2005) Diabetes causes inhibition of glucose-6-phosphate dehydrogenase via activation of PKA, which contributes to oxidative stress in rat kidney cortex. Am J Physiol Renal Physiol 289: F1040-F1047.
    • (2005) Am J Physiol Renal Physiol , vol.289
    • Xu, Y.1    Osborne, B.W.2    Stanton, R.C.3
  • 84
    • 34347402459 scopus 로고    scopus 로고
    • Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells
    • Yuneva M, Zamboni N, Oefner P, Sachidanandam R, Lazebnik Y (2007) Deficiency in glutamine but not glucose induces MYC-dependent apoptosis in human cells. J Cell Biol 178: 93-105.
    • (2007) J Cell Biol , vol.178 , pp. 93-105
    • Yuneva, M.1    Zamboni, N.2    Oefner, P.3    Sachidanandam, R.4    Lazebnik, Y.5
  • 85
    • 0034704167 scopus 로고    scopus 로고
    • High glucose inhibits glucose-6-phosphate dehydrogenase via cAMP in aortic endothelial cells
    • Zhang Z, Apse K, Pang J, Stanton RC (2000) High glucose inhibits glucose-6-phosphate dehydrogenase via cAMP in aortic endothelial cells. J Biol Chem 275: 40042-40047.
    • (2000) J Biol Chem , vol.275 , pp. 40042-40047
    • Zhang, Z.1    Apse, K.2    Pang, J.3    Stanton, R.C.4
  • 86
    • 64849098267 scopus 로고    scopus 로고
    • Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha
    • Zhao S, Lin Y, Xu W, Jiang W, Zha Z, Wang P, Yu W, Li Z, Gong L, Peng Y et al (2009) Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha. Science 324: 261-265.
    • (2009) Science , vol.324 , pp. 261-265
    • Zhao, S.1    Lin, Y.2    Xu, W.3    Jiang, W.4    Zha, Z.5    Wang, P.6    Yu, W.7    Li, Z.8    Gong, L.9    Peng, Y.10
  • 87
    • 77958501463 scopus 로고    scopus 로고
    • Exposure to hydrogen peroxide induces oxidation and activation of AMP-activated protein kinase
    • Zmijewski JW, Banerjee S, Bae H, Friggeri A, Lazarowski ER, Abraham E (2010) Exposure to hydrogen peroxide induces oxidation and activation of AMP-activated protein kinase. J Biol Chem 285: 33154-33164.
    • (2010) J Biol Chem , vol.285 , pp. 33154-33164
    • Zmijewski, J.W.1    Banerjee, S.2    Bae, H.3    Friggeri, A.4    Lazarowski, E.R.5    Abraham, E.6
  • 88
    • 78650510609 scopus 로고    scopus 로고
    • mTOR: from growth signal integration to cancer, diabetes and ageing
    • Zoncu R, Efeyan A, Sabatini DM (2011) mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 12: 21-35.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 89
    • 0141706665 scopus 로고    scopus 로고
    • Activation of 5'-AMP-activated kinase is mediated through c-Src and phosphoinositide 3-kinase activity during hypoxia-reoxygenation of bovine aortic endothelial cells. Role of peroxynitrite
    • Zou MH, Hou XY, Shi CM, Kirkpatick S, Liu F, Goldman MH, Cohen RA (2003) Activation of 5'-AMP-activated kinase is mediated through c-Src and phosphoinositide 3-kinase activity during hypoxia-reoxygenation of bovine aortic endothelial cells. Role of peroxynitrite. J Biol Chem 278: 34003-34010.
    • (2003) J Biol Chem , vol.278 , pp. 34003-34010
    • Zou, M.H.1    Hou, X.Y.2    Shi, C.M.3    Kirkpatick, S.4    Liu, F.5    Goldman, M.H.6    Cohen, R.A.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.