ANTINEOPLASTIC ACTIVITY;
CLINICAL TRIAL;
DRUG IDENTIFICATION;
DRUG SENSITIVITY;
DRUG SYNTHESIS;
HUMAN;
HYPOXIA;
NONHUMAN;
PRIORITY JOURNAL;
PROTEIN EXPRESSION;
SHORT SURVEY;
SOLID TUMOR;
TUMOR XENOGRAFT;
X RAY CRYSTALLOGRAPHY;
CHEMISTRY;
DRUG EFFECT;
ENZYMOLOGY;
METABOLISM;
NEOPLASM;
REVIEW;
Pastorekova S, Pastorek J. Cancerrelated carbonic anhydrase isozymes and their inhibition. In Supuran CT, Scozzafava A, Conway J eds, Carbonic Anhydrase - Its Inhibitors and Activators. Boca Raton, FL: CRC Press, 2004: 255-281
Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme II and IX
DOI 10.1021/ja061574s
Alterio V, Vitale RM, Monti SM et al. Carbonic anhydrase inhibitors: X-ray and molecular modeling study for the interaction of a fluorescent antitumor sulfonamide with isozyme Il and IX. J Am Chem Soc 2006; 128:8329-8335 (Pubitemid 43967776)
Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors
DOI 10.1021/jm0501073
Cecchi A, Hulikova A, Pastorek J et al. Carbonic anhydrase inhibitors. Design of fluorescent sulfonamides as probes of tumor-associated carbonic anhydrase IX that inhibit isozyme IX-mediated acidification of hypoxic tumors. J Med Chem 2005; 48: 4834-4841 (Pubitemid 41033126)
Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH
DOI 10.1016/j.febslet.2004.10.043, PII S0014579304012943
Svastova E, Hulikova A, Rafajova M et al. Hypoxia activates the capacity of tumor-associated carbonic anhydrase IX to acidify extracellular pH. FEBS Lett 2004; 577: 439-445 (Pubitemid 39535327)
Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes i and II, and transmembrane, tumor-associated isozyme IX
DOI 10.1016/j.bmcl.2003.09.062
Abbate F, Casini A, Owa T, Scozzafava A, Supuran CT. Carbonic anhydrase inhibitors: E7070, a sulfonamide anticancer agent, potently inhibits cytosolic isozymes I and II, and transmembrane, tumor-associated isozyme IX. Bioorg Med Chem Lett 2004; 14: 217-223 (Pubitemid 38010223)
