-
1
-
-
23644446866
-
Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis
-
Ackah E., Yu J., Zoellner S., Iwakiri Y., Skurk C., Shibata R., Ouchi N., Easton R.M., Galasso G., Birnbaum M.J., et al. Akt1/protein kinase Balpha is critical for ischemic and VEGF-mediated angiogenesis. J. Clin. Invest. 115 (2005) 2119-2127
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 2119-2127
-
-
Ackah, E.1
Yu, J.2
Zoellner, S.3
Iwakiri, Y.4
Skurk, C.5
Shibata, R.6
Ouchi, N.7
Easton, R.M.8
Galasso, G.9
Birnbaum, M.J.10
-
2
-
-
0029804116
-
Mechanism of activation of protein kinase B by insulin and IGF-1
-
Alessi D.R., Andjelkovic M., Caudwell B., Cron P., Morrice N., Cohen P., and Hemmings B.A. Mechanism of activation of protein kinase B by insulin and IGF-1. EMBO J. 15 (1996) 6541-6551
-
(1996)
EMBO J.
, vol.15
, pp. 6541-6551
-
-
Alessi, D.R.1
Andjelkovic, M.2
Caudwell, B.3
Cron, P.4
Morrice, N.5
Cohen, P.6
Hemmings, B.A.7
-
3
-
-
21244458013
-
Structure of S6K1 determines if raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site
-
Ali S.M., and Sabatini D.M. Structure of S6K1 determines if raptor-mTOR or rictor-mTOR phosphorylates its hydrophobic motif site. J. Biol. Chem. 280 (2005) 19445-19448
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 19445-19448
-
-
Ali, S.M.1
Sabatini, D.M.2
-
4
-
-
33750293584
-
Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling
-
Baba M., Hong S.B., Sharma N., Warren M.B., Nickerson M.L., Iwamatsu A., Esposito D., Gillette W.K., Hopkins III R.F., Hartley J.L., et al. Folliculin encoded by the BHD gene interacts with a binding protein, FNIP1, and AMPK, and is involved in AMPK and mTOR signaling. Proc. Natl. Acad. Sci. USA 103 (2006) 15552-15557
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 15552-15557
-
-
Baba, M.1
Hong, S.B.2
Sharma, N.3
Warren, M.B.4
Nickerson, M.L.5
Iwamatsu, A.6
Esposito, D.7
Gillette, W.K.8
Hopkins III, R.F.9
Hartley, J.L.10
-
5
-
-
33646341231
-
A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1
-
Bachmann R.A., Kim J.H., Wu A.L., Park I.H., and Chen J. A nuclear transport signal in mammalian target of rapamycin is critical for its cytoplasmic signaling to S6 kinase 1. J. Biol. Chem. 281 (2006) 7357-7363
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 7357-7363
-
-
Bachmann, R.A.1
Kim, J.H.2
Wu, A.L.3
Park, I.H.4
Chen, J.5
-
6
-
-
14144254701
-
Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors
-
Ballif B.A., Roux P.P., Gerber S.A., MacKeigan J.P., Blenis J., and Gygi S.P. Quantitative phosphorylation profiling of the ERK/p90 ribosomal S6 kinase-signaling cassette and its targets, the tuberous sclerosis tumor suppressors. Proc. Natl. Acad. Sci. USA 102 (2005) 667-672
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 667-672
-
-
Ballif, B.A.1
Roux, P.P.2
Gerber, S.A.3
MacKeigan, J.P.4
Blenis, J.5
Gygi, S.P.6
-
7
-
-
33747488399
-
PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR
-
Bernardi R., Guernah I., Jin D., Grisendi S., Alimonti A., Teruya-Feldstein J., Cordon-Cardo C., Simon M.C., Rafii S., and Pandolfi P.P. PML inhibits HIF-1alpha translation and neoangiogenesis through repression of mTOR. Nature 442 (2006) 779-785
-
(2006)
Nature
, vol.442
, pp. 779-785
-
-
Bernardi, R.1
Guernah, I.2
Jin, D.3
Grisendi, S.4
Alimonti, A.5
Teruya-Feldstein, J.6
Cordon-Cardo, C.7
Simon, M.C.8
Rafii, S.9
Pandolfi, P.P.10
-
8
-
-
0035882103
-
The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB
-
Biondi R.M., Kieloch A., Currie R.A., Deak M., and Alessi D.R. The PIF-binding pocket in PDK1 is essential for activation of S6K and SGK, but not PKB. EMBO J. 20 (2001) 4380-4390
-
(2001)
EMBO J.
, vol.20
, pp. 4380-4390
-
-
Biondi, R.M.1
Kieloch, A.2
Currie, R.A.3
Deak, M.4
Alessi, D.R.5
-
9
-
-
33947203621
-
PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms
-
Brognard J., Sierecki E., Gao T., and Newton A.C. PHLPP and a second isoform, PHLPP2, differentially attenuate the amplitude of Akt signaling by regulating distinct Akt isoforms. Mol. Cell 25 (2007) 917-931
-
(2007)
Mol. Cell
, vol.25
, pp. 917-931
-
-
Brognard, J.1
Sierecki, E.2
Gao, T.3
Newton, A.C.4
-
10
-
-
33646143793
-
Localization of Rheb to the endomembrane is critical for its signaling function
-
Buerger C., DeVries B., and Stambolic V. Localization of Rheb to the endomembrane is critical for its signaling function. Biochem. Biophys. Res. Commun. 344 (2006) 869-880
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.344
, pp. 869-880
-
-
Buerger, C.1
DeVries, B.2
Stambolic, V.3
-
11
-
-
1642371460
-
Conversion to sirolimus: a successful treatment for posttransplantation Kaposi's sarcoma
-
Campistol J.M., Gutierrez-Dalmau A., and Torregrosa J.V. Conversion to sirolimus: a successful treatment for posttransplantation Kaposi's sarcoma. Transplantation 77 (2004) 760-762
-
(2004)
Transplantation
, vol.77
, pp. 760-762
-
-
Campistol, J.M.1
Gutierrez-Dalmau, A.2
Torregrosa, J.V.3
-
12
-
-
33745172528
-
The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice
-
Chen M.L., Xu P.Z., Peng X.D., Chen W.S., Guzman G., Yang X., Di Cristofano A., Pandolfi P.P., and Hay N. The deficiency of Akt1 is sufficient to suppress tumor development in Pten+/- mice. Genes Dev. 20 (2006) 1569-1574
-
(2006)
Genes Dev.
, vol.20
, pp. 1569-1574
-
-
Chen, M.L.1
Xu, P.Z.2
Peng, X.D.3
Chen, W.S.4
Guzman, G.5
Yang, X.6
Di Cristofano, A.7
Pandolfi, P.P.8
Hay, N.9
-
13
-
-
21844468767
-
Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase
-
Chiang G.G., and Abraham R.T. Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase. J. Biol. Chem. 280 (2005) 25485-25490
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 25485-25490
-
-
Chiang, G.G.1
Abraham, R.T.2
-
14
-
-
0036774805
-
The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase
-
Choi J.H., Bertram P.G., Drenan R., Carvalho J., Zhou H.H., and Zheng X.F. The FKBP12-rapamycin-associated protein (FRAP) is a CLIP-170 kinase. EMBO Rep. 3 (2002) 988-994
-
(2002)
EMBO Rep.
, vol.3
, pp. 988-994
-
-
Choi, J.H.1
Bertram, P.G.2
Drenan, R.3
Carvalho, J.4
Zhou, H.H.5
Zheng, X.F.6
-
15
-
-
0042967831
-
In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation
-
Collins B.J., Deak M., Arthur J.S., Armit L.J., and Alessi D.R. In vivo role of the PIF-binding docking site of PDK1 defined by knock-in mutation. EMBO J. 22 (2003) 4202-4211
-
(2003)
EMBO J.
, vol.22
, pp. 4202-4211
-
-
Collins, B.J.1
Deak, M.2
Arthur, J.S.3
Armit, L.J.4
Alessi, D.R.5
-
16
-
-
3042818799
-
Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome
-
Corradetti M.N., Inoki K., Bardeesy N., DePinho R.A., and Guan K.L. Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome. Genes Dev. 18 (2004) 1533-1538
-
(2004)
Genes Dev.
, vol.18
, pp. 1533-1538
-
-
Corradetti, M.N.1
Inoki, K.2
Bardeesy, N.3
DePinho, R.A.4
Guan, K.L.5
-
18
-
-
0037007014
-
FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction
-
Desai B.N., Myers B.R., and Schreiber S.L. FKBP12-rapamycin-associated protein associates with mitochondria and senses osmotic stress via mitochondrial dysfunction. Proc. Natl. Acad. Sci. USA 99 (2002) 4319-4324
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 4319-4324
-
-
Desai, B.N.1
Myers, B.R.2
Schreiber, S.L.3
-
20
-
-
5444233787
-
Tsc2 is not a critical target of Akt during normal Drosophila development
-
Dong J., and Pan D. Tsc2 is not a critical target of Akt during normal Drosophila development. Genes Dev. 18 (2004) 2479-2484
-
(2004)
Genes Dev.
, vol.18
, pp. 2479-2484
-
-
Dong, J.1
Pan, D.2
-
21
-
-
33750325725
-
S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth
-
Dorrello N.V., Peschiaroli A., Guardavaccaro D., Colburn N.H., Sherman N.E., and Pagano M. S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth. Science 314 (2006) 467-471
-
(2006)
Science
, vol.314
, pp. 467-471
-
-
Dorrello, N.V.1
Peschiaroli, A.2
Guardavaccaro, D.3
Colburn, N.H.4
Sherman, N.E.5
Pagano, M.6
-
22
-
-
0346422440
-
FKBP12-rapamycin-associated protein or mammalian target of rapamycin (FRAP/mTOR) localization in the endoplasmic reticulum and the Golgi apparatus
-
Drenan R.M., Liu X., Bertram P.G., and Zheng X.F. FKBP12-rapamycin-associated protein or mammalian target of rapamycin (FRAP/mTOR) localization in the endoplasmic reticulum and the Golgi apparatus. J. Biol. Chem. 279 (2004) 772-778
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 772-778
-
-
Drenan, R.M.1
Liu, X.2
Bertram, P.G.3
Zheng, X.F.4
-
23
-
-
33750072949
-
mTOR and cancer therapy
-
Easton J.B., and Houghton P.J. mTOR and cancer therapy. Oncogene 25 (2006) 6436-6446
-
(2006)
Oncogene
, vol.25
, pp. 6436-6446
-
-
Easton, J.B.1
Houghton, P.J.2
-
24
-
-
0042316755
-
PTEN: one gene, many syndromes
-
Eng C. PTEN: one gene, many syndromes. Hum. Mutat. 22 (2003) 183-198
-
(2003)
Hum. Mutat.
, vol.22
, pp. 183-198
-
-
Eng, C.1
-
25
-
-
33746637660
-
Current development of mTOR inhibitors as anticancer agents
-
Faivre S., Kroemer G., and Raymond E. Current development of mTOR inhibitors as anticancer agents. Nat. Rev. Drug Discov. 5 (2006) 671-688
-
(2006)
Nat. Rev. Drug Discov.
, vol.5
, pp. 671-688
-
-
Faivre, S.1
Kroemer, G.2
Raymond, E.3
-
26
-
-
33751225349
-
Isoform specific inhibitors of PI3 kinase in glioma
-
Fan Q.W., and Weiss W.A. Isoform specific inhibitors of PI3 kinase in glioma. Cell Cycle 5 (2006) 2301-2305
-
(2006)
Cell Cycle
, vol.5
, pp. 2301-2305
-
-
Fan, Q.W.1
Weiss, W.A.2
-
27
-
-
34147141941
-
A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling
-
Findlay G.M., Yan L., Procter J., Mieulet V., and Lamb R.F. A MAP4 kinase related to Ste20 is a nutrient-sensitive regulator of mTOR signalling. Biochem. J. 430 (2007) 13-20
-
(2007)
Biochem. J.
, vol.430
, pp. 13-20
-
-
Findlay, G.M.1
Yan, L.2
Procter, J.3
Mieulet, V.4
Lamb, R.F.5
-
28
-
-
33644827461
-
Rapamycin causes regression of astrocytomas in tuberous sclerosis complex
-
Franz D.N., Leonard J., Tudor C., Chuck G., Care M., Sethuraman G., Dinopoulos A., Thomas G., and Crone K.R. Rapamycin causes regression of astrocytomas in tuberous sclerosis complex. Ann. Neurol. 59 (2006) 490-498
-
(2006)
Ann. Neurol.
, vol.59
, pp. 490-498
-
-
Franz, D.N.1
Leonard, J.2
Tudor, C.3
Chuck, G.4
Care, M.5
Sethuraman, G.6
Dinopoulos, A.7
Thomas, G.8
Crone, K.R.9
-
29
-
-
33748471980
-
mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s
-
Frias M.A., Thoreen C.C., Jaffe J.D., Schroder W., Sculley T., Carr S.A., and Sabatini D.M. mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s. Curr. Biol. 16 (2006) 1865-1870
-
(2006)
Curr. Biol.
, vol.16
, pp. 1865-1870
-
-
Frias, M.A.1
Thoreen, C.C.2
Jaffe, J.D.3
Schroder, W.4
Sculley, T.5
Carr, S.A.6
Sabatini, D.M.7
-
30
-
-
27144556646
-
Cell size reduction induced by inhibition of the mTOR/S6K-signaling pathway protects Jurkat cells from apoptosis
-
Fumarola C., La Monica S., Alfieri R.R., Borra E., and Guidotti G.G. Cell size reduction induced by inhibition of the mTOR/S6K-signaling pathway protects Jurkat cells from apoptosis. Cell Death Differ. 12 (2005) 1344-1357
-
(2005)
Cell Death Differ.
, vol.12
, pp. 1344-1357
-
-
Fumarola, C.1
La Monica, S.2
Alfieri, R.R.3
Borra, E.4
Guidotti, G.G.5
-
31
-
-
4544227785
-
Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice
-
Furuyama T., Kitayama K., Shimoda Y., Ogawa M., Sone K., Yoshida-Araki K., Hisatsune H., Nishikawa S., Nakayama K., Ikeda K., et al. Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice. J. Biol. Chem. 279 (2004) 34741-34749
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 34741-34749
-
-
Furuyama, T.1
Kitayama, K.2
Shimoda, Y.3
Ogawa, M.4
Sone, K.5
Yoshida-Araki, K.6
Hisatsune, H.7
Nishikawa, S.8
Nakayama, K.9
Ikeda, K.10
-
32
-
-
6344245674
-
Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development
-
Gangloff Y.G., Mueller M., Dann S.G., Svoboda P., Sticker M., Spetz J.F., Um S.H., Brown E.J., Cereghini S., Thomas G., and Kozma S.C. Disruption of the mouse mTOR gene leads to early postimplantation lethality and prohibits embryonic stem cell development. Mol. Cell. Biol. 24 (2004) 9508-9516
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 9508-9516
-
-
Gangloff, Y.G.1
Mueller, M.2
Dann, S.G.3
Svoboda, P.4
Sticker, M.5
Spetz, J.F.6
Um, S.H.7
Brown, E.J.8
Cereghini, S.9
Thomas, G.10
Kozma, S.C.11
-
33
-
-
15944406764
-
PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth
-
Gao T., Furnari F., and Newton A.C. PHLPP: a phosphatase that directly dephosphorylates Akt, promotes apoptosis, and suppresses tumor growth. Mol. Cell 18 (2005) 13-24
-
(2005)
Mol. Cell
, vol.18
, pp. 13-24
-
-
Gao, T.1
Furnari, F.2
Newton, A.C.3
-
34
-
-
33748127085
-
Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival
-
Ghosh S., Tergaonkar V., Rothlin C.V., Correa R.G., Bottero V., Bist P., Verma I.M., and Hunter T. Essential role of tuberous sclerosis genes TSC1 and TSC2 in NF-kappaB activation and cell survival. Cancer Cell 10 (2006) 215-226
-
(2006)
Cancer Cell
, vol.10
, pp. 215-226
-
-
Ghosh, S.1
Tergaonkar, V.2
Rothlin, C.V.3
Correa, R.G.4
Bottero, V.5
Bist, P.6
Verma, I.M.7
Hunter, T.8
-
35
-
-
32944465388
-
Handicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway
-
Granville C.A., Memmott R.M., Gills J.J., and Dennis P.A. Handicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway. Clin. Cancer Res. 12 (2006) 679-689
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 679-689
-
-
Granville, C.A.1
Memmott, R.M.2
Gills, J.J.3
Dennis, P.A.4
-
36
-
-
34247520866
-
Identification of a Highly Effective Rapamycin Schedule that Markedly Reduces the Size, Multiplicity, and Phenotypic Progression of Tobacco Carcinogen-Induced Murine Lung Tumors
-
Granville C.A., Warfel N., Tsurutani J., Hollander M.C., Robertson M., Fox S.D., Veenstra T.D., Issaq H.J., Linnoila R.I., and Dennis P.A. Identification of a Highly Effective Rapamycin Schedule that Markedly Reduces the Size, Multiplicity, and Phenotypic Progression of Tobacco Carcinogen-Induced Murine Lung Tumors. Clin. Cancer Res. 13 (2007) 2281-2289
-
(2007)
Clin. Cancer Res.
, vol.13
, pp. 2281-2289
-
-
Granville, C.A.1
Warfel, N.2
Tsurutani, J.3
Hollander, M.C.4
Robertson, M.5
Fox, S.D.6
Veenstra, T.D.7
Issaq, H.J.8
Linnoila, R.I.9
Dennis, P.A.10
-
37
-
-
27844497945
-
FOXO transcription factors at the interface between longevity and tumor suppression
-
Greer E.L., and Brunet A. FOXO transcription factors at the interface between longevity and tumor suppression. Oncogene 24 (2005) 7410-7425
-
(2005)
Oncogene
, vol.24
, pp. 7410-7425
-
-
Greer, E.L.1
Brunet, A.2
-
38
-
-
0036174289
-
Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor
-
Guba M., von Breitenbuch P., Steinbauer M., Koehl G., Flegel S., Hornung M., Bruns C.J., Zuelke C., Farkas S., Anthuber M., et al. Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor. Nat. Med. 8 (2002) 128-135
-
(2002)
Nat. Med.
, vol.8
, pp. 128-135
-
-
Guba, M.1
von Breitenbuch, P.2
Steinbauer, M.3
Koehl, G.4
Flegel, S.5
Hornung, M.6
Bruns, C.J.7
Zuelke, C.8
Farkas, S.9
Anthuber, M.10
-
39
-
-
33646566510
-
Functional genomics identifies TOR-regulated genes that control growth and division
-
Guertin D.A., Guntur K.V., Bell G.W., Thoreen C.C., and Sabatini D.M. Functional genomics identifies TOR-regulated genes that control growth and division. Curr. Biol. 16 (2006) 958-970
-
(2006)
Curr. Biol.
, vol.16
, pp. 958-970
-
-
Guertin, D.A.1
Guntur, K.V.2
Bell, G.W.3
Thoreen, C.C.4
Sabatini, D.M.5
-
40
-
-
23144467910
-
An expanding role for mTOR in cancer
-
Guertin D.A., and Sabatini D.M. An expanding role for mTOR in cancer. Trends Mol. Med. 11 (2005) 353-361
-
(2005)
Trends Mol. Med.
, vol.11
, pp. 353-361
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
41
-
-
33751348056
-
Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCalpha, but Not S6K1
-
Guertin D.A., Stevens D.M., Thoreen C.C., Burds A.A., Kalaany N.Y., Moffat J., Brown M., Fitzgerald K.J., and Sabatini D.M. Ablation in Mice of the mTORC Components raptor, rictor, or mLST8 Reveals that mTORC2 Is Required for Signaling to Akt-FOXO and PKCalpha, but Not S6K1. Dev. Cell 11 (2006) 859-871
-
(2006)
Dev. Cell
, vol.11
, pp. 859-871
-
-
Guertin, D.A.1
Stevens, D.M.2
Thoreen, C.C.3
Burds, A.A.4
Kalaany, N.Y.5
Moffat, J.6
Brown, M.7
Fitzgerald, K.J.8
Sabatini, D.M.9
-
42
-
-
33847397874
-
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
-
Haar E.V., Lee S.I., Bandhakavi S., Griffin T.J., and Kim D.H. Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40. Nat. Cell Biol. 9 (2007) 316-323
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 316-323
-
-
Haar, E.V.1
Lee, S.I.2
Bandhakavi, S.3
Griffin, T.J.4
Kim, D.H.5
-
43
-
-
1542328927
-
Structure, regulation and function of PKB/AKT-a major therapeutic target
-
Hanada M., Feng J., and Hemmings B.A. Structure, regulation and function of PKB/AKT-a major therapeutic target. Biochim. Biophys. Acta 1697 (2004) 3-16
-
(2004)
Biochim. Biophys. Acta
, vol.1697
, pp. 3-16
-
-
Hanada, M.1
Feng, J.2
Hemmings, B.A.3
-
44
-
-
0037178781
-
Raptor, a binding partner of target of rapamycin (TOR) mediates TOR Action
-
Hara K., Maruki Y., Long X., Yoshino K., Oshiro N., Hidayat S., Tokunaga C., Avruch J., and Yonezawa K. Raptor, a binding partner of target of rapamycin (TOR) mediates TOR Action. Cell 110 (2002) 177-189
-
(2002)
Cell
, vol.110
, pp. 177-189
-
-
Hara, K.1
Maruki, Y.2
Long, X.3
Yoshino, K.4
Oshiro, N.5
Hidayat, S.6
Tokunaga, C.7
Avruch, J.8
Yonezawa, K.9
-
45
-
-
0037099620
-
Transcript map of the 3.7-Mb D19S112-D19S246 candidate tumor suppressor region on the long arm of chromosome 19
-
Hartmann C., Johnk L., Kitange G., Wu Y., Ashworth L.K., Jenkins R.B., and Louis D.N. Transcript map of the 3.7-Mb D19S112-D19S246 candidate tumor suppressor region on the long arm of chromosome 19. Cancer Res. 62 (2002) 4100-4108
-
(2002)
Cancer Res.
, vol.62
, pp. 4100-4108
-
-
Hartmann, C.1
Johnk, L.2
Kitange, G.3
Wu, Y.4
Ashworth, L.K.5
Jenkins, R.B.6
Louis, D.N.7
-
46
-
-
33947330747
-
Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth
-
Hietakangas V., and Cohen S.M. Re-evaluating AKT regulation: role of TOR complex 2 in tissue growth. Genes Dev. 21 (2007) 632-637
-
(2007)
Genes Dev.
, vol.21
, pp. 632-637
-
-
Hietakangas, V.1
Cohen, S.M.2
-
47
-
-
27144455334
-
Inhibition of the mammalian target of rapamycin and the induction of cell cycle arrest in mantle cell lymphoma cells
-
Hipp S., Ringshausen I., Oelsner M., Bogner C., Peschel C., and Decker T. Inhibition of the mammalian target of rapamycin and the induction of cell cycle arrest in mantle cell lymphoma cells. Haematologica 90 (2005) 1433-1434
-
(2005)
Haematologica
, vol.90
, pp. 1433-1434
-
-
Hipp, S.1
Ringshausen, I.2
Oelsner, M.3
Bogner, C.4
Peschel, C.5
Decker, T.6
-
48
-
-
27744569843
-
mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events
-
Holz M.K., Ballif B.A., Gygi S.P., and Blenis J. mTOR and S6K1 mediate assembly of the translation preinitiation complex through dynamic protein interchange and ordered phosphorylation events. Cell 123 (2005) 569-580
-
(2005)
Cell
, vol.123
, pp. 569-580
-
-
Holz, M.K.1
Ballif, B.A.2
Gygi, S.P.3
Blenis, J.4
-
49
-
-
22544455676
-
Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase
-
Holz M.K., and Blenis J. Identification of S6 kinase 1 as a novel mammalian target of rapamycin (mTOR)-phosphorylating kinase. J. Biol. Chem. 280 (2005) 26089-26093
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 26089-26093
-
-
Holz, M.K.1
Blenis, J.2
-
50
-
-
1542267804
-
Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification
-
Hosaka T., Biggs III W.H., Tieu D., Boyer A.D., Varki N.M., Cavenee W.K., and Arden K.C. Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification. Proc. Natl. Acad. Sci. USA 101 (2004) 2975-2980
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 2975-2980
-
-
Hosaka, T.1
Biggs III, W.H.2
Tieu, D.3
Boyer, A.D.4
Varki, N.M.5
Cavenee, W.K.6
Arden, K.C.7
-
51
-
-
28844434558
-
mTOR/RICTOR is the Ser473 kinase for Akt/PKB in 3T3-L1 adipocytes
-
Hresko R.C., and Mueckler M. mTOR/RICTOR is the Ser473 kinase for Akt/PKB in 3T3-L1 adipocytes. J. Biol. Chem. 280 (2005) 40406-40416
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 40406-40416
-
-
Hresko, R.C.1
Mueckler, M.2
-
52
-
-
33847174115
-
Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase
-
Hsu Y.C., Chern J.J., Cai Y., Liu M., and Choi K.W. Drosophila TCTP is essential for growth and proliferation through regulation of dRheb GTPase. Nature 445 (2007) 785-788
-
(2007)
Nature
, vol.445
, pp. 785-788
-
-
Hsu, Y.C.1
Chern, J.J.2
Cai, Y.3
Liu, M.4
Choi, K.W.5
-
53
-
-
26044474979
-
Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis
-
Huang B., and Porter G. Expression of proline-rich Akt-substrate PRAS40 in cell survival pathway and carcinogenesis. Acta Pharmacol. Sin. 26 (2005) 1253-1258
-
(2005)
Acta Pharmacol. Sin.
, vol.26
, pp. 1253-1258
-
-
Huang, B.1
Porter, G.2
-
54
-
-
0036789574
-
Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin
-
Hudson C.C., Liu M., Chiang G.G., Otterness D.M., Loomis D.C., Kaper F., Giaccia A.J., and Abraham R.T. Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol. Cell. Biol. 22 (2002) 7004-7014
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 7004-7014
-
-
Hudson, C.C.1
Liu, M.2
Chiang, G.G.3
Otterness, D.M.4
Loomis, D.C.5
Kaper, F.6
Giaccia, A.J.7
Abraham, R.T.8
-
55
-
-
0037154264
-
Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin
-
Huffman T.A., Mothe-Satney I., and Lawrence Jr. J.C. Insulin-stimulated phosphorylation of lipin mediated by the mammalian target of rapamycin. Proc. Natl. Acad. Sci. USA 99 (2002) 1047-1052
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 1047-1052
-
-
Huffman, T.A.1
Mothe-Satney, I.2
Lawrence Jr., J.C.3
-
56
-
-
1542373392
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
Inoki K., Li Y., Zhu T., Wu J., and Guan K.L. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 12 (2002) 12
-
(2002)
Nat. Cell Biol.
, vol.12
, pp. 12
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.L.5
-
57
-
-
33748153690
-
TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth
-
Inoki K., Ouyang H., Zhu T., Lindvall C., Wang Y., Zhang X., Yang Q., Bennett C., Harada Y., Stankunas K., et al. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 126 (2006) 955-968
-
(2006)
Cell
, vol.126
, pp. 955-968
-
-
Inoki, K.1
Ouyang, H.2
Zhu, T.3
Lindvall, C.4
Wang, Y.5
Zhang, X.6
Yang, Q.7
Bennett, C.8
Harada, Y.9
Stankunas, K.10
-
58
-
-
0345167800
-
TSC2 mediates cellular energy response to control cell growth and survival
-
Inoki K., Zhu T., and Guan K.L. TSC2 mediates cellular energy response to control cell growth and survival. Cell 115 (2003) 577-590
-
(2003)
Cell
, vol.115
, pp. 577-590
-
-
Inoki, K.1
Zhu, T.2
Guan, K.L.3
-
59
-
-
33749076673
-
SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity
-
Jacinto E., Facchinetti V., Liu D., Soto N., Wei S., Jung S.Y., Huang Q., Qin J., and Su B. SIN1/MIP1 Maintains rictor-mTOR Complex Integrity and Regulates Akt Phosphorylation and Substrate Specificity. Cell 127 (2006) 125-137
-
(2006)
Cell
, vol.127
, pp. 125-137
-
-
Jacinto, E.1
Facchinetti, V.2
Liu, D.3
Soto, N.4
Wei, S.5
Jung, S.Y.6
Huang, Q.7
Qin, J.8
Su, B.9
-
60
-
-
7944235758
-
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
-
Jacinto E., Loewith R., Schmidt A., Lin S., Ruegg M.A., Hall A., and Hall M.N. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat. Cell Biol. 6 (2004) 1122-1128
-
(2004)
Nat. Cell Biol.
, vol.6
, pp. 1122-1128
-
-
Jacinto, E.1
Loewith, R.2
Schmidt, A.3
Lin, S.4
Ruegg, M.A.5
Hall, A.6
Hall, M.N.7
-
61
-
-
0037191045
-
Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent
-
Jaeschke A., Hartkamp J., Saitoh M., Roworth W., Nobukuni T., Hodges A., Sampson J., Thomas G., and Lamb R. Tuberous sclerosis complex tumor suppressor-mediated S6 kinase inhibition by phosphatidylinositide-3-OH kinase is mTOR independent. J. Cell Biol. 159 (2002) 217-224
-
(2002)
J. Cell Biol.
, vol.159
, pp. 217-224
-
-
Jaeschke, A.1
Hartkamp, J.2
Saitoh, M.3
Roworth, W.4
Nobukuni, T.5
Hodges, A.6
Sampson, J.7
Thomas, G.8
Lamb, R.9
-
62
-
-
20844435467
-
The NF1 tumor suppressor critically regulates TSC2 and mTOR
-
Johannessen C.M., Reczek E.E., James M.F., Brems H., Legius E., and Cichowski K. The NF1 tumor suppressor critically regulates TSC2 and mTOR. Proc. Natl. Acad. Sci. USA 102 (2005) 8573-8578
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 8573-8578
-
-
Johannessen, C.M.1
Reczek, E.E.2
James, M.F.3
Brems, H.4
Legius, E.5
Cichowski, K.6
-
63
-
-
0037178786
-
mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery
-
Kim D.-H., Sarbassov D.D., Ali S.M., King J.E., Latek R.R., Erdjument-Bromage H., Tempst P., and Sabatini D.M. mTOR Interacts with Raptor to Form a Nutrient-Sensitive Complex that Signals to the Cell Growth Machinery. Cell 110 (2002) 163-175
-
(2002)
Cell
, vol.110
, pp. 163-175
-
-
Kim, D.-H.1
Sarbassov, D.D.2
Ali, S.M.3
King, J.E.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
64
-
-
0037623417
-
GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
-
Kim D.-H., Sarbassov D.D., Ali S.M., Latek R.R., Guntur K.V., Erdjument-Bromage H., Tempst P., and Sabatini D.M. GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol. Cell 11 (2003) 895-904
-
(2003)
Mol. Cell
, vol.11
, pp. 895-904
-
-
Kim, D.-H.1
Sarbassov, D.D.2
Ali, S.M.3
Latek, R.R.4
Guntur, K.V.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
65
-
-
0034687688
-
Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation
-
Kim J.E., and Chen J. Cytoplasmic-nuclear shuttling of FKBP12-rapamycin-associated protein is involved in rapamycin-sensitive signaling and translation initiation. Proc. Natl. Acad. Sci. USA 97 (2000) 14340-14345
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 14340-14345
-
-
Kim, J.E.1
Chen, J.2
-
66
-
-
16644373473
-
Role of VHL gene mutation in human cancer
-
Kim W.Y., and Kaelin W.G. Role of VHL gene mutation in human cancer. J. Clin. Oncol. 22 (2004) 4991-5004
-
(2004)
J. Clin. Oncol.
, vol.22
, pp. 4991-5004
-
-
Kim, W.Y.1
Kaelin, W.G.2
-
67
-
-
0037855834
-
Identification of a proline-rich Akt substrate as a 14-3-3 binding partner
-
Kovacina K.S., Park G.Y., Bae S.S., Guzzetta A.W., Schaefer E., Birnbaum M.J., and Roth R.A. Identification of a proline-rich Akt substrate as a 14-3-3 binding partner. J. Biol. Chem. 278 (2003) 10189-10194
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 10189-10194
-
-
Kovacina, K.S.1
Park, G.Y.2
Bae, S.S.3
Guzzetta, A.W.4
Schaefer, E.5
Birnbaum, M.J.6
Roth, R.A.7
-
68
-
-
0036501277
-
A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells
-
Kwiatkowski D.J., Zhang H., Bandura J.L., Heiberger K.M., Glogauer M., el-Hashemite N., and Onda H. A mouse model of TSC1 reveals sex-dependent lethality from liver hemangiomas, and up-regulation of p70S6 kinase activity in Tsc1 null cells. Hum. Mol. Genet. 11 (2002) 525-534
-
(2002)
Hum. Mol. Genet.
, vol.11
, pp. 525-534
-
-
Kwiatkowski, D.J.1
Zhang, H.2
Bandura, J.L.3
Heiberger, K.M.4
Glogauer, M.5
el-Hashemite, N.6
Onda, H.7
-
69
-
-
26244438381
-
TOR Complex 2 Integrates Cell Movement during Chemotaxis and Signal Relay in Dictyostelium
-
Lee S., Comer F.I., Sasaki A., McLeod I.X., Duong Y., Okumura K., Yates III J.R., Parent C.A., and Firtel R.A. TOR Complex 2 Integrates Cell Movement during Chemotaxis and Signal Relay in Dictyostelium. Mol. Biol. Cell 16 (2005) 4572-4583
-
(2005)
Mol. Biol. Cell
, vol.16
, pp. 4572-4583
-
-
Lee, S.1
Comer, F.I.2
Sasaki, A.3
McLeod, I.X.4
Duong, Y.5
Okumura, K.6
Yates III, J.R.7
Parent, C.A.8
Firtel, R.A.9
-
70
-
-
0032849043
-
A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium
-
Lee S., Parent C.A., Insall R., and Firtel R.A. A novel Ras-interacting protein required for chemotaxis and cyclic adenosine monophosphate signal relay in Dictyostelium. Mol. Biol. Cell 10 (1999) 2829-2845
-
(1999)
Mol. Biol. Cell
, vol.10
, pp. 2829-2845
-
-
Lee, S.1
Parent, C.A.2
Insall, R.3
Firtel, R.A.4
-
71
-
-
33846080045
-
Hypoxia-induced endothelial proliferation requires both mTORC1 and mTORC2
-
Li W., Petrimpol M., Molle K.D., Hall M.N., Battegay E.J., and Humar R. Hypoxia-induced endothelial proliferation requires both mTORC1 and mTORC2. Circ. Res. 100 (2007) 79-87
-
(2007)
Circ. Res.
, vol.100
, pp. 79-87
-
-
Li, W.1
Petrimpol, M.2
Molle, K.D.3
Hall, M.N.4
Battegay, E.J.5
Humar, R.6
-
72
-
-
33947250696
-
The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis
-
Liang J., Shao S.H., Xu Z.X., Hennessy B., Ding Z., Larrea M., Kondo S., Dumont D.J., Gutterman J.U., Walker C.L., et al. The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat. Cell Biol. 9 (2007) 218-224
-
(2007)
Nat. Cell Biol.
, vol.9
, pp. 218-224
-
-
Liang, J.1
Shao, S.H.2
Xu, Z.X.3
Hennessy, B.4
Ding, Z.5
Larrea, M.6
Kondo, S.7
Dumont, D.J.8
Gutterman, J.U.9
Walker, C.L.10
-
73
-
-
33947145667
-
Endoplasmic reticulum and Golgi localization sequences for Mammalian target of rapamycin
-
Liu X., and Zheng X.F. Endoplasmic reticulum and Golgi localization sequences for Mammalian target of rapamycin. Mol. Biol. Cell 18 (2007) 1073-1082
-
(2007)
Mol. Biol. Cell
, vol.18
, pp. 1073-1082
-
-
Liu, X.1
Zheng, X.F.2
-
74
-
-
0036753494
-
Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
-
Loewith R., Jacinto E., Wullschleger S., Lorberg A., Crespo J.L., Bonenfant D., Oppliger W., Jenoe P., and Hall M.N. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol. Cell 10 (2002) 457-468
-
(2002)
Mol. Cell
, vol.10
, pp. 457-468
-
-
Loewith, R.1
Jacinto, E.2
Wullschleger, S.3
Lorberg, A.4
Crespo, J.L.5
Bonenfant, D.6
Oppliger, W.7
Jenoe, P.8
Hall, M.N.9
-
75
-
-
17444431201
-
Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis
-
Ma L., Chen Z., Erdjument-Bromage H., Tempst P., and Pandolfi P.P. Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 121 (2005) 179-193
-
(2005)
Cell
, vol.121
, pp. 179-193
-
-
Ma, L.1
Chen, Z.2
Erdjument-Bromage, H.3
Tempst, P.4
Pandolfi, P.P.5
-
76
-
-
23744484194
-
Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression
-
Ma L., Teruya-Feldstein J., Behrendt N., Chen Z., Noda T., Hino O., Cordon-Cardo C., and Pandolfi P.P. Genetic analysis of Pten and Tsc2 functional interactions in the mouse reveals asymmetrical haploinsufficiency in tumor suppression. Genes Dev. 19 (2005) 1779-1786
-
(2005)
Genes Dev.
, vol.19
, pp. 1779-1786
-
-
Ma, L.1
Teruya-Feldstein, J.2
Behrendt, N.3
Chen, Z.4
Noda, T.5
Hino, O.6
Cordon-Cardo, C.7
Pandolfi, P.P.8
-
77
-
-
2942724235
-
mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways
-
Majumder P.K., Febbo P.G., Bikoff R., Berger R., Xue Q., McMahon L.M., Manola J., Brugarolas J., McDonnell T.J., Golub T.R., et al. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat. Med. 10 (2004) 594-601
-
(2004)
Nat. Med.
, vol.10
, pp. 594-601
-
-
Majumder, P.K.1
Febbo, P.G.2
Bikoff, R.3
Berger, R.4
Xue, Q.5
McMahon, L.M.6
Manola, J.7
Brugarolas, J.8
McDonnell, T.J.9
Golub, T.R.10
-
78
-
-
8444224619
-
Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis
-
Manning B.D. Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis. J. Cell Biol. 167 (2004) 399-403
-
(2004)
J. Cell Biol.
, vol.167
, pp. 399-403
-
-
Manning, B.D.1
-
79
-
-
23744516268
-
Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2
-
Manning B.D., Logsdon M.N., Lipovsky A.I., Abbott D., Kwiatkowski D.J., and Cantley L.C. Feedback inhibition of Akt signaling limits the growth of tumors lacking Tsc2. Genes Dev. 19 (2005) 1773-1778
-
(2005)
Genes Dev.
, vol.19
, pp. 1773-1778
-
-
Manning, B.D.1
Logsdon, M.N.2
Lipovsky, A.I.3
Abbott, D.4
Kwiatkowski, D.J.5
Cantley, L.C.6
-
80
-
-
0036342294
-
Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway
-
Manning B.D., Tee A.R., Logsdon M.N., Blenis J., and Cantley L.C. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide 3-kinase/akt pathway. Mol. Cell 10 (2002) 151-162
-
(2002)
Mol. Cell
, vol.10
, pp. 151-162
-
-
Manning, B.D.1
Tee, A.R.2
Logsdon, M.N.3
Blenis, J.4
Cantley, L.C.5
-
81
-
-
2942563750
-
The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation
-
McManus E.J., Collins B.J., Ashby P.R., Prescott A.R., Murray-Tait V., Armit L.J., Arthur J.S., and Alessi D.R. The in vivo role of PtdIns(3,4,5)P3 binding to PDK1 PH domain defined by knockin mutation. EMBO J. 23 (2004) 2071-2082
-
(2004)
EMBO J.
, vol.23
, pp. 2071-2082
-
-
McManus, E.J.1
Collins, B.J.2
Ashby, P.R.3
Prescott, A.R.4
Murray-Tait, V.5
Armit, L.J.6
Arthur, J.S.7
Alessi, D.R.8
-
82
-
-
3242721268
-
mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells
-
Murakami M., Ichisaka T., Maeda M., Oshiro N., Hara K., Edenhofer F., Kiyama H., Yonezawa K., and Yamanaka S. mTOR is essential for growth and proliferation in early mouse embryos and embryonic stem cells. Mol. Cell. Biol. 24 (2004) 6710-6718
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 6710-6718
-
-
Murakami, M.1
Ichisaka, T.2
Maeda, M.3
Oshiro, N.4
Hara, K.5
Edenhofer, F.6
Kiyama, H.7
Yonezawa, K.8
Yamanaka, S.9
-
83
-
-
17944377486
-
Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR
-
Neshat M.S., Mellinghoff I.K., Tran C., Stiles B., Thomas G., Petersen R., Frost P., Gibbons J.J., Wu H., and Sawyers C.L. Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc. Natl. Acad. Sci. USA 98 (2001) 10314-10319
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 10314-10319
-
-
Neshat, M.S.1
Mellinghoff, I.K.2
Tran, C.3
Stiles, B.4
Thomas, G.5
Petersen, R.6
Frost, P.7
Gibbons, J.J.8
Wu, H.9
Sawyers, C.L.10
-
84
-
-
26444575415
-
Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase
-
Nobukuni T., Joaquin M., Roccio M., Dann S.G., Kim S.Y., Gulati P., Byfield M.P., Backer J.M., Natt F., Bos J.L., et al. Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. Proc. Natl. Acad. Sci. USA 102 (2005) 14238-14243
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 14238-14243
-
-
Nobukuni, T.1
Joaquin, M.2
Roccio, M.3
Dann, S.G.4
Kim, S.Y.5
Gulati, P.6
Byfield, M.P.7
Backer, J.M.8
Natt, F.9
Bos, J.L.10
-
85
-
-
33846295218
-
FoxOs Are Lineage-Restricted Redundant Tumor Suppressors and Regulate Endothelial Cell Homeostasis
-
Paik J.H., Kollipara R., Chu G., Ji H., Xiao Y., Ding Z., Miao L., Tothova Z., Horner J.W., Carrasco D.R., et al. FoxOs Are Lineage-Restricted Redundant Tumor Suppressors and Regulate Endothelial Cell Homeostasis. Cell 128 (2007) 309-323
-
(2007)
Cell
, vol.128
, pp. 309-323
-
-
Paik, J.H.1
Kollipara, R.2
Chu, G.3
Ji, H.4
Xiao, Y.5
Ding, Z.6
Miao, L.7
Tothova, Z.8
Horner, J.W.9
Carrasco, D.R.10
-
86
-
-
34347210090
-
Identification of Protor as a novel Rictor-binding component of mTOR-complex-2
-
10.1042/BJ20070540 In press. Published online April 27, 2007
-
Pearce L.R., Huang X., Boudeau J., Pawlowski R., Wullschleger S., Deak M., Ibrahim A., Gourlay R., Magnuson M.A., and Alessi D.R. Identification of Protor as a novel Rictor-binding component of mTOR-complex-2. Biochem. J. (2007) 10.1042/BJ20070540 In press. Published online April 27, 2007
-
(2007)
Biochem. J.
-
-
Pearce, L.R.1
Huang, X.2
Boudeau, J.3
Pawlowski, R.4
Wullschleger, S.5
Deak, M.6
Ibrahim, A.7
Gourlay, R.8
Magnuson, M.A.9
Alessi, D.R.10
-
87
-
-
33746800144
-
Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin
-
Phung T.L., Ziv K., Dabydeen D., Eyiah-Mensah G., Riveros M., Perruzzi C., Sun J., Monahan-Earley R.A., Shiojima I., Nagy J.A., et al. Pathological angiogenesis is induced by sustained Akt signaling and inhibited by rapamycin. Cancer Cell 10 (2006) 159-170
-
(2006)
Cancer Cell
, vol.10
, pp. 159-170
-
-
Phung, T.L.1
Ziv, K.2
Dabydeen, D.3
Eyiah-Mensah, G.4
Riveros, M.5
Perruzzi, C.6
Sun, J.7
Monahan-Earley, R.A.8
Shiojima, I.9
Nagy, J.A.10
-
88
-
-
13044250465
-
Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems
-
Podsypanina K., Ellenson L.H., Nemes A., Gu J., Tamura M., Yamada K.M., Cordon-Cardo C., Catoretti G., Fisher P.E., and Parsons R. Mutation of Pten/Mmac1 in mice causes neoplasia in multiple organ systems. Proc. Natl. Acad. Sci. USA 96 (1999) 1563-1568
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 1563-1568
-
-
Podsypanina, K.1
Ellenson, L.H.2
Nemes, A.3
Gu, J.4
Tamura, M.5
Yamada, K.M.6
Cordon-Cardo, C.7
Catoretti, G.8
Fisher, P.E.9
Parsons, R.10
-
89
-
-
17944368972
-
An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice
-
Podsypanina K., Lee R.T., Politis C., Hennessy I., Crane A., Puc J., Neshat M., Wang H., Yang L., Gibbons J., et al. An inhibitor of mTOR reduces neoplasia and normalizes p70/S6 kinase activity in Pten+/- mice. Proc. Natl. Acad. Sci. USA 98 (2001) 10320-10325
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 10320-10325
-
-
Podsypanina, K.1
Lee, R.T.2
Politis, C.3
Hennessy, I.4
Crane, A.5
Puc, J.6
Neshat, M.7
Wang, H.8
Yang, L.9
Gibbons, J.10
-
90
-
-
24644519938
-
Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization
-
Potente M., Urbich C., Sasaki K., Hofmann W.K., Heeschen C., Aicher A., Kollipara R., DePinho R.A., Zeiher A.M., and Dimmeler S. Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization. J. Clin. Invest. 115 (2005) 2382-2392
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 2382-2392
-
-
Potente, M.1
Urbich, C.2
Sasaki, K.3
Hofmann, W.K.4
Heeschen, C.5
Aicher, A.6
Kollipara, R.7
DePinho, R.A.8
Zeiher, A.M.9
Dimmeler, S.10
-
91
-
-
27744507024
-
mTOR, a new therapeutic target in acute myeloid leukemia
-
Recher C., Dos Santos C., Demur C., and Payrastre B. mTOR, a new therapeutic target in acute myeloid leukemia. Cell Cycle 4 (2005) 1540-1549
-
(2005)
Cell Cycle
, vol.4
, pp. 1540-1549
-
-
Recher, C.1
Dos Santos, C.2
Demur, C.3
Payrastre, B.4
-
92
-
-
33750044112
-
Stress and mTORture signaling
-
Reiling J.H., and Sabatini D.M. Stress and mTORture signaling. Oncogene 25 (2006) 6373-6383
-
(2006)
Oncogene
, vol.25
, pp. 6373-6383
-
-
Reiling, J.H.1
Sabatini, D.M.2
-
93
-
-
4544384577
-
Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase
-
Roux P.P., Ballif B.A., Anjum R., Gygi S.P., and Blenis J. Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase. Proc. Natl. Acad. Sci. USA 101 (2004) 13489-13494
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 13489-13494
-
-
Roux, P.P.1
Ballif, B.A.2
Anjum, R.3
Gygi, S.P.4
Blenis, J.5
-
94
-
-
33747846726
-
Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma
-
Rudelius M., Pittaluga S., Nishizuka S., Pham T.H., Fend F., Jaffe E.S., Quintanilla-Martinez L., and Raffeld M. Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma. Blood 108 (2006) 1668-1676
-
(2006)
Blood
, vol.108
, pp. 1668-1676
-
-
Rudelius, M.1
Pittaluga, S.2
Nishizuka, S.3
Pham, T.H.4
Fend, F.5
Jaffe, E.S.6
Quintanilla-Martinez, L.7
Raffeld, M.8
-
95
-
-
0033553624
-
Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling
-
Sabatini D.M., Barrow R.K., Blackshaw S., Burnett P.E., Lai M.M., Field M.E., Bahr B.A., Kirsch J., Betz H., and Snyder S.H. Interaction of RAFT1 with gephyrin required for rapamycin-sensitive signaling. Science 284 (1999) 1161-1164
-
(1999)
Science
, vol.284
, pp. 1161-1164
-
-
Sabatini, D.M.1
Barrow, R.K.2
Blackshaw, S.3
Burnett, P.E.4
Lai, M.M.5
Field, M.E.6
Bahr, B.A.7
Kirsch, J.8
Betz, H.9
Snyder, S.H.10
-
96
-
-
20444374445
-
Mutant PIK3CA promotes cell growth and invasion of human cancer cells
-
Samuels Y., Diaz Jr. L.A., Schmidt-Kittler O., Cummins J.M., Delong L., Cheong I., Rago C., Huso D.L., Lengauer C., Kinzler K.W., et al. Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell 7 (2005) 561-573
-
(2005)
Cancer Cell
, vol.7
, pp. 561-573
-
-
Samuels, Y.1
Diaz Jr., L.A.2
Schmidt-Kittler, O.3
Cummins, J.M.4
Delong, L.5
Cheong, I.6
Rago, C.7
Huso, D.L.8
Lengauer, C.9
Kinzler, K.W.10
-
97
-
-
33947264077
-
PRAS40 Is an Insulin-Regulated Inhibitor of the mTORC1 Protein Kinase
-
Sancak Y., Thoreen C.C., Peterson T.R., Lindquist R.A., Kang S.A., Spooner E., Carr S.A., and Sabatini D.M. PRAS40 Is an Insulin-Regulated Inhibitor of the mTORC1 Protein Kinase. Mol. Cell 25 (2007) 903-915
-
(2007)
Mol. Cell
, vol.25
, pp. 903-915
-
-
Sancak, Y.1
Thoreen, C.C.2
Peterson, T.R.3
Lindquist, R.A.4
Kang, S.A.5
Spooner, E.6
Carr, S.A.7
Sabatini, D.M.8
-
99
-
-
33646023695
-
Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB
-
Sarbassov D., Ali S.M., Sengupta S., Sheen J.H., Hsu P.P., Bagley A.F., Markhard A.L., and Sabatini D.M. Prolonged rapamycin treatment inhibits mTORC2 assembly and Akt/PKB. Mol. Cell 22 (2006) 159-168
-
(2006)
Mol. Cell
, vol.22
, pp. 159-168
-
-
Sarbassov, D.1
Ali, S.M.2
Sengupta, S.3
Sheen, J.H.4
Hsu, P.P.5
Bagley, A.F.6
Markhard, A.L.7
Sabatini, D.M.8
-
100
-
-
28244469041
-
Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex
-
Sarbassov D., and Sabatini D.M. Redox regulation of the nutrient-sensitive raptor-mTOR pathway and complex. J. Biol. Chem. 280 (2005) 39505-39509
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 39505-39509
-
-
Sarbassov, D.1
Sabatini, D.M.2
-
101
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
-
Sarbassov D.D., Ali S.M., Kim D.H., Guertin D.A., Latek R.R., Erdjument-Bromage H., Tempst P., and Sabatini D.M. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr. Biol. 14 (2004) 1296-1302
-
(2004)
Curr. Biol.
, vol.14
, pp. 1296-1302
-
-
Sarbassov, D.D.1
Ali, S.M.2
Kim, D.H.3
Guertin, D.A.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
102
-
-
13844312400
-
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
-
Sarbassov D.D., Guertin D.A., Ali S.M., and Sabatini D.M. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307 (2005) 1098-1101
-
(2005)
Science
, vol.307
, pp. 1098-1101
-
-
Sarbassov, D.D.1
Guertin, D.A.2
Ali, S.M.3
Sabatini, D.M.4
-
103
-
-
0037718389
-
TOS Motif-Mediated Raptor Binding Regulates 4E-BP1 Multisite Phosphorylation and Function
-
Schalm S.S., Fingar D.C., Sabatini D.M., and Blenis J. TOS Motif-Mediated Raptor Binding Regulates 4E-BP1 Multisite Phosphorylation and Function. Curr. Biol. 13 (2003) 797-806
-
(2003)
Curr. Biol.
, vol.13
, pp. 797-806
-
-
Schalm, S.S.1
Fingar, D.C.2
Sabatini, D.M.3
Blenis, J.4
-
104
-
-
4444377577
-
Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene
-
Schroder W., Cloonan N., Bushell G., and Sculley T. Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene. Gene 339 (2004) 17-23
-
(2004)
Gene
, vol.339
, pp. 17-23
-
-
Schroder, W.1
Cloonan, N.2
Bushell, G.3
Sculley, T.4
-
105
-
-
34147097962
-
Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signallling
-
in press
-
Schroder W.A., Buck M., Cloonan N., Hancock J.F., Suhrbier A., Sculley T., and Bushell G. Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signallling. Cell. Signal. (2007) in press
-
(2007)
Cell. Signal.
-
-
Schroder, W.A.1
Buck, M.2
Cloonan, N.3
Hancock, J.F.4
Suhrbier, A.5
Sculley, T.6
Bushell, G.7
-
106
-
-
0034234924
-
A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells
-
Sekulic A., Hudson C.C., Homme J.L., Yin P., Otterness D.M., Karnitz L.M., and Abraham R.T. A direct linkage between the phosphoinositide 3-kinase-AKT signaling pathway and the mammalian target of rapamycin in mitogen-stimulated and transformed cells. Cancer Res. 60 (2000) 3504-3513
-
(2000)
Cancer Res.
, vol.60
, pp. 3504-3513
-
-
Sekulic, A.1
Hudson, C.C.2
Homme, J.L.3
Yin, P.4
Otterness, D.M.5
Karnitz, L.M.6
Abraham, R.T.7
-
107
-
-
3142594193
-
The LKB1 tumor suppressor negatively regulates mTOR signaling
-
Shaw R.J., Bardeesy N., Manning B.D., Lopez L., Kosmatka M., DePinho R.A., and Cantley L.C. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 6 (2004) 91-99
-
(2004)
Cancer Cell
, vol.6
, pp. 91-99
-
-
Shaw, R.J.1
Bardeesy, N.2
Manning, B.D.3
Lopez, L.4
Kosmatka, M.5
DePinho, R.A.6
Cantley, L.C.7
-
108
-
-
33748950810
-
Multiallelic Disruption of the rictor Gene in Mice Reveals that mTOR Complex 2 Is Essential for Fetal Growth and Viability
-
Shiota C., Woo J.T., Lindner J., Shelton K.D., and Magnuson M.A. Multiallelic Disruption of the rictor Gene in Mice Reveals that mTOR Complex 2 Is Essential for Fetal Growth and Viability. Dev. Cell 11 (2006) 583-589
-
(2006)
Dev. Cell
, vol.11
, pp. 583-589
-
-
Shiota, C.1
Woo, J.T.2
Lindner, J.3
Shelton, K.D.4
Magnuson, M.A.5
-
109
-
-
33749430399
-
Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner
-
Skeen J.E., Bhaskar P.T., Chen C.C., Chen W.S., Peng X.D., Nogueira V., Hahn-Windgassen A., Kiyokawa H., and Hay N. Akt deficiency impairs normal cell proliferation and suppresses oncogenesis in a p53-independent and mTORC1-dependent manner. Cancer Cell 10 (2006) 269-280
-
(2006)
Cancer Cell
, vol.10
, pp. 269-280
-
-
Skeen, J.E.1
Bhaskar, P.T.2
Chen, C.C.3
Chen, W.S.4
Peng, X.D.5
Nogueira, V.6
Hahn-Windgassen, A.7
Kiyokawa, H.8
Hay, N.9
-
110
-
-
21244480367
-
The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses
-
Smith E.M., Finn S.G., Tee A.R., Browne G.J., and Proud C.G. The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses. J. Biol. Chem. 280 (2005) 18717-18727
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 18717-18727
-
-
Smith, E.M.1
Finn, S.G.2
Tee, A.R.3
Browne, G.J.4
Proud, C.G.5
-
111
-
-
33746832011
-
The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor
-
Sodhi A., Chaisuparat R., Hu J., Ramsdell A.K., Manning B.D., Sausville E.A., Sawai E.T., Molinolo A., Gutkind J.S., and Montaner S. The TSC2/mTOR pathway drives endothelial cell transformation induced by the Kaposi's sarcoma-associated herpesvirus G protein-coupled receptor. Cancer Cell 10 (2006) 133-143
-
(2006)
Cancer Cell
, vol.10
, pp. 133-143
-
-
Sodhi, A.1
Chaisuparat, R.2
Hu, J.3
Ramsdell, A.K.4
Manning, B.D.5
Sausville, E.A.6
Sawai, E.T.7
Molinolo, A.8
Gutkind, J.S.9
Montaner, S.10
-
112
-
-
1842687489
-
Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor
-
Sodhi A., Montaner S., Patel V., Gomez-Roman J.J., Li Y., Sausville E.A., Sawai E.T., and Gutkind J.S. Akt plays a central role in sarcomagenesis induced by Kaposi's sarcoma herpesvirus-encoded G protein-coupled receptor. Proc. Natl. Acad. Sci. USA 101 (2004) 4821-4826
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 4821-4826
-
-
Sodhi, A.1
Montaner, S.2
Patel, V.3
Gomez-Roman, J.J.4
Li, Y.5
Sausville, E.A.6
Sawai, E.T.7
Gutkind, J.S.8
-
113
-
-
20144367584
-
Sirolimus for Kaposi's sarcoma in renal-transplant recipients
-
Stallone G., Schena A., Infante B., Di Paolo S., Loverre A., Maggio G., Ranieri E., Gesualdo L., Schena F.P., and Grandaliano G. Sirolimus for Kaposi's sarcoma in renal-transplant recipients. N. Engl. J. Med. 352 (2005) 1317-1323
-
(2005)
N. Engl. J. Med.
, vol.352
, pp. 1317-1323
-
-
Stallone, G.1
Schena, A.2
Infante, B.3
Di Paolo, S.4
Loverre, A.5
Maggio, G.6
Ranieri, E.7
Gesualdo, L.8
Schena, F.P.9
Grandaliano, G.10
-
114
-
-
0032493029
-
Genetic analysis of protein kinase B (AKT) in Drosophila
-
Staveley B.E., Ruel L., Jin J., Stambolic V., Mastronardi F.G., Heitzler P., Woodgett J.R., and Manoukian A.S. Genetic analysis of protein kinase B (AKT) in Drosophila. Curr. Biol. 8 (1998) 599-602
-
(1998)
Curr. Biol.
, vol.8
, pp. 599-602
-
-
Staveley, B.E.1
Ruel, L.2
Jin, J.3
Stambolic, V.4
Mastronardi, F.G.5
Heitzler, P.6
Woodgett, J.R.7
Manoukian, A.S.8
-
115
-
-
13144249184
-
High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice
-
Suzuki A., de la Pompa J.L., Stambolic V., Elia A.J., Sasaki T., del Barco Barrantes I., Ho A., Wakeham A., Itie A., Khoo W., et al. High cancer susceptibility and embryonic lethality associated with mutation of the PTEN tumor suppressor gene in mice. Curr. Biol. 8 (1998) 1169-1178
-
(1998)
Curr. Biol.
, vol.8
, pp. 1169-1178
-
-
Suzuki, A.1
de la Pompa, J.L.2
Stambolic, V.3
Elia, A.J.4
Sasaki, T.5
del Barco Barrantes, I.6
Ho, A.7
Wakeham, A.8
Itie, A.9
Khoo, W.10
-
116
-
-
28044456974
-
Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2
-
Tavazoie S.F., Alvarez V.A., Ridenour D.A., Kwiatkowski D.J., and Sabatini B.L. Regulation of neuronal morphology and function by the tumor suppressors Tsc1 and Tsc2. Nat. Neurosci. 8 (2005) 1727-1734
-
(2005)
Nat. Neurosci.
, vol.8
, pp. 1727-1734
-
-
Tavazoie, S.F.1
Alvarez, V.A.2
Ridenour, D.A.3
Kwiatkowski, D.J.4
Sabatini, B.L.5
-
117
-
-
30044432434
-
Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer
-
Thomas G.V., Tran C., Mellinghoff I.K., Welsbie D.S., Chan E., Fueger B., Czernin J., and Sawyers C.L. Hypoxia-inducible factor determines sensitivity to inhibitors of mTOR in kidney cancer. Nat. Med. 12 (2006) 122-127
-
(2006)
Nat. Med.
, vol.12
, pp. 122-127
-
-
Thomas, G.V.1
Tran, C.2
Mellinghoff, I.K.3
Welsbie, D.S.4
Chan, E.5
Fueger, B.6
Czernin, J.7
Sawyers, C.L.8
-
118
-
-
0141885091
-
The PCPH oncoprotein antagonizes the proapoptotic role of the mammalian target of rapamycin in the response of normal fibroblasts to ionizing radiation
-
Tirado O.M., Mateo-Lozano S., Sanders S., Dettin L.E., and Notario V. The PCPH oncoprotein antagonizes the proapoptotic role of the mammalian target of rapamycin in the response of normal fibroblasts to ionizing radiation. Cancer Res. 63 (2003) 6290-6298
-
(2003)
Cancer Res.
, vol.63
, pp. 6290-6298
-
-
Tirado, O.M.1
Mateo-Lozano, S.2
Sanders, S.3
Dettin, L.E.4
Notario, V.5
-
119
-
-
33846419112
-
FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress
-
Tothova Z., Kollipara R., Huntly B.J., Lee B.H., Castrillon D.H., Cullen D.E., McDowell E.P., Lazo-Kallanian S., Williams I.R., Sears C., et al. FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress. Cell 128 (2007) 325-339
-
(2007)
Cell
, vol.128
, pp. 325-339
-
-
Tothova, Z.1
Kollipara, R.2
Huntly, B.J.3
Lee, B.H.4
Castrillon, D.H.5
Cullen, D.E.6
McDowell, E.P.7
Lazo-Kallanian, S.8
Williams, I.R.9
Sears, C.10
-
120
-
-
4544220704
-
Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity
-
Um S.H., Frigerio F., Watanabe M., Picard F., Joaquin M., Sticker M., Fumagalli S., Allegrini P.R., Kozma S.C., Auwerx J., and Thomas G. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 431 (2004) 200-205
-
(2004)
Nature
, vol.431
, pp. 200-205
-
-
Um, S.H.1
Frigerio, F.2
Watanabe, M.3
Picard, F.4
Joaquin, M.5
Sticker, M.6
Fumagalli, S.7
Allegrini, P.R.8
Kozma, S.C.9
Auwerx, J.10
Thomas, G.11
-
121
-
-
27944452168
-
Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast
-
Urano J., Comiso M.J., Guo L., Aspuria P.J., Deniskin R., Tabancay Jr. A.P., Kato-Stankiewicz J., and Tamanoi F. Identification of novel single amino acid changes that result in hyperactivation of the unique GTPase, Rheb, in fission yeast. Mol. Microbiol. 58 (2005) 1074-1086
-
(2005)
Mol. Microbiol.
, vol.58
, pp. 1074-1086
-
-
Urano, J.1
Comiso, M.J.2
Guo, L.3
Aspuria, P.J.4
Deniskin, R.5
Tabancay Jr., A.P.6
Kato-Stankiewicz, J.7
Tamanoi, F.8
-
122
-
-
33751190328
-
Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPase
-
Uritani M., Hidaka H., Hotta Y., Ueno M., Ushimaru T., and Toda T. Fission yeast Tor2 links nitrogen signals to cell proliferation and acts downstream of the Rheb GTPase. Genes Cells 11 (2006) 1367-1379
-
(2006)
Genes Cells
, vol.11
, pp. 1367-1379
-
-
Uritani, M.1
Hidaka, H.2
Hotta, Y.3
Ueno, M.4
Ushimaru, T.5
Toda, T.6
-
123
-
-
33947538050
-
Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism
-
10.1038/sj.onc.1209990 Published online September 25, 2006
-
Wan X., Harkavy B., Shen N., Grohar P., and Helman L.J. Rapamycin induces feedback activation of Akt signaling through an IGF-1R-dependent mechanism. Oncogene 26 (2007) 1932-1940 10.1038/sj.onc.1209990 Published online September 25, 2006
-
(2007)
Oncogene
, vol.26
, pp. 1932-1940
-
-
Wan, X.1
Harkavy, B.2
Shen, N.3
Grohar, P.4
Helman, L.J.5
-
124
-
-
33846007729
-
Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1
-
Wang H., Kubica N., Ellisen L.W., Jefferson L.S., and Kimball S.R. Dexamethasone represses signaling through the mammalian target of rapamycin in muscle cells by enhancing expression of REDD1. J. Biol. Chem. 281 (2006) 39128-39134
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 39128-39134
-
-
Wang, H.1
Kubica, N.2
Ellisen, L.W.3
Jefferson, L.S.4
Kimball, S.R.5
-
125
-
-
24144472585
-
Biology and therapy of mantle cell lymphoma
-
Williams M.E., and Densmore J.J. Biology and therapy of mantle cell lymphoma. Curr. Opin. Oncol. 17 (2005) 425-431
-
(2005)
Curr. Opin. Oncol.
, vol.17
, pp. 425-431
-
-
Williams, M.E.1
Densmore, J.J.2
-
126
-
-
0031590781
-
Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells
-
Withers D.J., Ouwens D.M., Nave B.T., van der Zon G.C., Alarcon C.M., Cardenas M.E., Heitman J., Maassen J.A., and Shepherd P.R. Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells. Biochem. Biophys. Res. Commun. 241 (1997) 704-709
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.241
, pp. 704-709
-
-
Withers, D.J.1
Ouwens, D.M.2
Nave, B.T.3
van der Zon, G.C.4
Alarcon, C.M.5
Cardenas, M.E.6
Heitman, J.7
Maassen, J.A.8
Shepherd, P.R.9
-
127
-
-
23944481410
-
Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma
-
Witzig T.E., Geyer S.M., Ghobrial I., Inwards D.J., Fonseca R., Kurtin P., Ansell S.M., Luyun R., Flynn P.J., Morton R.F., et al. Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma. J. Clin. Oncol. 23 (2005) 5347-5356
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 5347-5356
-
-
Witzig, T.E.1
Geyer, S.M.2
Ghobrial, I.3
Inwards, D.J.4
Fonseca, R.5
Kurtin, P.6
Ansell, S.M.7
Luyun, R.8
Flynn, P.J.9
Morton, R.F.10
-
128
-
-
33745909399
-
Inhibition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway in hematologic malignancies
-
Witzig T.E., and Kaufmann S.H. Inhibition of the phosphatidylinositol 3-kinase/mammalian target of rapamycin pathway in hematologic malignancies. Curr. Treat. Options Oncol. 7 (2006) 285-294
-
(2006)
Curr. Treat. Options Oncol.
, vol.7
, pp. 285-294
-
-
Witzig, T.E.1
Kaufmann, S.H.2
-
129
-
-
32044465506
-
TOR signaling in growth and metabolism
-
Wullschleger S., Loewith R., and Hall M.N. TOR signaling in growth and metabolism. Cell 124 (2006) 471-484
-
(2006)
Cell
, vol.124
, pp. 471-484
-
-
Wullschleger, S.1
Loewith, R.2
Hall, M.N.3
-
130
-
-
33751079895
-
Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity
-
Yang Q., Inoki K., Ikenoue T., and Guan K.L. Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity. Genes Dev. 20 (2006) 2820-2832
-
(2006)
Genes Dev.
, vol.20
, pp. 2820-2832
-
-
Yang, Q.1
Inoki, K.2
Ikenoue, T.3
Guan, K.L.4
-
131
-
-
27944493875
-
Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice
-
Yang Z.Z., Tschopp O., Di-Poi N., Bruder E., Baudry A., Dummler B., Wahli W., and Hemmings B.A. Dosage-dependent effects of Akt1/protein kinase Balpha (PKBalpha) and Akt3/PKBgamma on thymus, skin, and cardiovascular and nervous system development in mice. Mol. Cell. Biol. 25 (2005) 10407-10418
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 10407-10418
-
-
Yang, Z.Z.1
Tschopp, O.2
Di-Poi, N.3
Bruder, E.4
Baudry, A.5
Dummler, B.6
Wahli, W.7
Hemmings, B.A.8
-
132
-
-
0042357084
-
Protein kinase B alpha/Akt1 regulates placental development and fetal growth
-
Yang Z.Z., Tschopp O., Hemmings-Mieszczak M., Feng J., Brodbeck D., Perentes E., and Hemmings B.A. Protein kinase B alpha/Akt1 regulates placental development and fetal growth. J. Biol. Chem. 278 (2003) 32124-32131
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 32124-32131
-
-
Yang, Z.Z.1
Tschopp, O.2
Hemmings-Mieszczak, M.3
Feng, J.4
Brodbeck, D.5
Perentes, E.6
Hemmings, B.A.7
-
133
-
-
33646376411
-
Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
-
Yilmaz O.H., Valdez R., Theisen B.K., Guo W., Ferguson D.O., Wu H., and Morrison S.J. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 441 (2006) 475-482
-
(2006)
Nature
, vol.441
, pp. 475-482
-
-
Yilmaz, O.H.1
Valdez, R.2
Theisen, B.K.3
Guo, W.4
Ferguson, D.O.5
Wu, H.6
Morrison, S.J.7
-
134
-
-
0033968596
-
Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR
-
Yokogami K., Wakisaka S., Avruch J., and Reeves S.A. Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR. Curr. Biol. 10 (2000) 47-50
-
(2000)
Curr. Biol.
, vol.10
, pp. 47-50
-
-
Yokogami, K.1
Wakisaka, S.2
Avruch, J.3
Reeves, S.A.4
-
135
-
-
34147146014
-
Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML
-
10.1182/blood-2006-06-030833 Published online December 19, 2006
-
Zeng Z., Sarbassov D.D., Samudio I.J., Yee K.W., Munsell M.F., Jackson C.E., Giles F.J., Sabatini D.M., Andreeff M., and Konopleva M. Rapamycin derivatives reduce mTORC2 signaling and inhibit AKT activation in AML. Blood 109 (2007) 3509-3512 10.1182/blood-2006-06-030833 Published online December 19, 2006
-
(2007)
Blood
, vol.109
, pp. 3509-3512
-
-
Zeng, Z.1
Sarbassov, D.D.2
Samudio, I.J.3
Yee, K.W.4
Munsell, M.F.5
Jackson, C.E.6
Giles, F.J.7
Sabatini, D.M.8
Andreeff, M.9
Konopleva, M.10
-
136
-
-
33847394119
-
PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR
-
Zhang H., Bajraszewski N., Wu E., Wang H., Moseman A.P., Dabora S.L., Griffin J.D., and Kwiatkowski D.J. PDGFRs are critical for PI3K/Akt activation and negatively regulated by mTOR. J. Clin. Invest. 117 (2007) 730-738
-
(2007)
J. Clin. Invest.
, vol.117
, pp. 730-738
-
-
Zhang, H.1
Bajraszewski, N.2
Wu, E.3
Wang, H.4
Moseman, A.P.5
Dabora, S.L.6
Griffin, J.D.7
Kwiatkowski, D.J.8
-
137
-
-
33750040886
-
S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt
-
Zhang H.H., Lipovsky A.I., Dibble C.C., Sahin M., and Manning B.D. S6K1 regulates GSK3 under conditions of mTOR-dependent feedback inhibition of Akt. Mol. Cell 24 (2006) 185-197
-
(2006)
Mol. Cell
, vol.24
, pp. 185-197
-
-
Zhang, H.H.1
Lipovsky, A.I.2
Dibble, C.C.3
Sahin, M.4
Manning, B.D.5
-
138
-
-
33244481462
-
Ser/Thr phosphorylation of IRS proteins: A molecular basis for insulin resistance
-
Zick Y. Ser/Thr phosphorylation of IRS proteins: A molecular basis for insulin resistance. Sci. STKE 2005 (2005) pe4
-
(2005)
Sci. STKE
, vol.2005
-
-
Zick, Y.1
|