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Volumn 22, Issue 4, 2012, Pages 335-341

Tumor metabolism as modulator of immune response and tumor progression

Author keywords

Glucose metabolism; Immunosuppression; Tumor metabolism; Tumor specific T cells

Indexed keywords

5' METHYLTHIOADENOSINE PHOSPHORYLASE; ADENOSINE; ARGININE; DEOXYGLUCOSE; DICHLOROACETIC ACID; GLUTAMINE; IMATINIB; INDOLEAMINE 2,3 DIOXYGENASE; LACTIC ACID; MONOCARBOXYLATE TRANSPORTER; PENTOSE PHOSPHATE; PROSTAGLANDIN SYNTHASE; TRYPTOPHAN;

EID: 84862145949     PISSN: 1044579X     EISSN: 10963650     Source Type: Journal    
DOI: 10.1016/j.semcancer.2012.02.009     Document Type: Review
Times cited : (94)

References (127)
  • 1
    • 85006768050 scopus 로고
    • The metabolism of tumors in the body
    • Warburg O., Wind F., Negelein E. The metabolism of tumors in the body. J Gen Physiol 1927, 8:519-530.
    • (1927) J Gen Physiol , vol.8 , pp. 519-530
    • Warburg, O.1    Wind, F.2    Negelein, E.3
  • 2
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science 1956, 123:309-314.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 3
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: the metabolic requirements of cell proliferation
    • Vander Heiden M.G., Cantley L.C., Thompson C.B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009, 324:1029-1033.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 4
    • 17844383964 scopus 로고    scopus 로고
    • Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements
    • Ramanathan A., Wang C., Schreiber S.L. Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements. Proc Natl Acad Sci USA 2005, 102:5992-5997.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 5992-5997
    • Ramanathan, A.1    Wang, C.2    Schreiber, S.L.3
  • 6
    • 40749163248 scopus 로고    scopus 로고
    • The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
    • Christofk H.R., Vander Heiden M.G., Harris M.H., Ramanathan A., Gerszten R.E., Wei R., et al. The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth. Nature 2008, 452:230-233.
    • (2008) Nature , vol.452 , pp. 230-233
    • Christofk, H.R.1    Vander Heiden, M.G.2    Harris, M.H.3    Ramanathan, A.4    Gerszten, R.E.5    Wei, R.6
  • 7
    • 0022930036 scopus 로고
    • The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing
    • Noguchi T., Inoue H., Tanaka T. The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing. J Biol Chem 1986, 261:13807-13812.
    • (1986) J Biol Chem , vol.261 , pp. 13807-13812
    • Noguchi, T.1    Inoue, H.2    Tanaka, T.3
  • 12
    • 0033587146 scopus 로고    scopus 로고
    • The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
    • Maxwell P.H., Wiesener M.S., Chang G.W., Clifford S.C., Vaux E.C., Cockman M.E., et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 1999, 399:271-275.
    • (1999) Nature , vol.399 , pp. 271-275
    • Maxwell, P.H.1    Wiesener, M.S.2    Chang, G.W.3    Clifford, S.C.4    Vaux, E.C.5    Cockman, M.E.6
  • 13
    • 33845803145 scopus 로고    scopus 로고
    • Hypoxia-independent overexpression of hypoxia-inducible factor 1alpha as an early change in mouse hepatocarcinogenesis
    • Tanaka H., Yamamoto M., Hashimoto N., Miyakoshi M., Tamakawa S., Yoshie M., et al. Hypoxia-independent overexpression of hypoxia-inducible factor 1alpha as an early change in mouse hepatocarcinogenesis. Cancer Res 2006, 66:11263-11270.
    • (2006) Cancer Res , vol.66 , pp. 11263-11270
    • Tanaka, H.1    Yamamoto, M.2    Hashimoto, N.3    Miyakoshi, M.4    Tamakawa, S.5    Yoshie, M.6
  • 14
    • 0035012605 scopus 로고    scopus 로고
    • HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
    • Laughner E., Taghavi P., Chiles K., Mahon P.C., Semenza G.L. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol 2001, 21:3995-4004.
    • (2001) Mol Cell Biol , vol.21 , pp. 3995-4004
    • Laughner, E.1    Taghavi, P.2    Chiles, K.3    Mahon, P.C.4    Semenza, G.L.5
  • 15
    • 61749083162 scopus 로고    scopus 로고
    • HIF-1alpha determines the metastatic potential of gastric cancer cells
    • Rohwer N., Lobitz S., Daskalow K., Jons T., Vieth M., Schlag P.M., et al. HIF-1alpha determines the metastatic potential of gastric cancer cells. Br J Cancer 2009, 100:772-781.
    • (2009) Br J Cancer , vol.100 , pp. 772-781
    • Rohwer, N.1    Lobitz, S.2    Daskalow, K.3    Jons, T.4    Vieth, M.5    Schlag, P.M.6
  • 16
    • 33847023140 scopus 로고    scopus 로고
    • Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting
    • Dewhirst M.W. Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting. Cancer Res 2007, 67:854-855.
    • (2007) Cancer Res , vol.67 , pp. 854-855
    • Dewhirst, M.W.1
  • 17
    • 77957786826 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1alpha determines gastric cancer chemosensitivity via modulation of p53 and NF-kappaB
    • Rohwer N., Dame C., Haugstetter A., Wiedenmann B., Detjen K., Schmitt C.A., et al. Hypoxia-inducible factor 1alpha determines gastric cancer chemosensitivity via modulation of p53 and NF-kappaB. PLoS One 2010, 5:e12038.
    • (2010) PLoS One , vol.5
    • Rohwer, N.1    Dame, C.2    Haugstetter, A.3    Wiedenmann, B.4    Detjen, K.5    Schmitt, C.A.6
  • 18
    • 78149330949 scopus 로고    scopus 로고
    • HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
    • Corzo C.A., Condamine T., Lu L., Cotter M.J., Youn J.I., Cheng P., et al. HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J Exp Med 2010, 207:2439-2453.
    • (2010) J Exp Med , vol.207 , pp. 2439-2453
    • Corzo, C.A.1    Condamine, T.2    Lu, L.3    Cotter, M.J.4    Youn, J.I.5    Cheng, P.6
  • 19
    • 4944244259 scopus 로고    scopus 로고
    • Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues
    • Murdoch C., Giannoudis A., Lewis C.E. Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood 2004, 104:2224-2234.
    • (2004) Blood , vol.104 , pp. 2224-2234
    • Murdoch, C.1    Giannoudis, A.2    Lewis, C.E.3
  • 21
    • 47749114537 scopus 로고    scopus 로고
    • Blocking CD147 induces cell death in cancer cells through impairment of glycolytic energy metabolism
    • Baba M., Inoue M., Itoh K., Nishizawa Y. Blocking CD147 induces cell death in cancer cells through impairment of glycolytic energy metabolism. Biochem Biophys Res Commun 2008, 374:111-116.
    • (2008) Biochem Biophys Res Commun , vol.374 , pp. 111-116
    • Baba, M.1    Inoue, M.2    Itoh, K.3    Nishizawa, Y.4
  • 22
    • 60549091044 scopus 로고    scopus 로고
    • Hyaluronan, CD44, and emmprin regulate lactate efflux and membrane localization of monocarboxylate transporters in human breast carcinoma cells
    • Slomiany M.G., Grass G.D., Robertson A.D., Yang X.Y., Maria B.L., Beeson C., et al. Hyaluronan, CD44, and emmprin regulate lactate efflux and membrane localization of monocarboxylate transporters in human breast carcinoma cells. Cancer Res 2009, 69:1293-1301.
    • (2009) Cancer Res , vol.69 , pp. 1293-1301
    • Slomiany, M.G.1    Grass, G.D.2    Robertson, A.D.3    Yang, X.Y.4    Maria, B.L.5    Beeson, C.6
  • 23
    • 50249166551 scopus 로고    scopus 로고
    • Cellular localization of EMMPRIN predicts prognosis of patients with operable lung adenocarcinoma independent from MMP-2 and MMP-9
    • Sienel W., Polzer B., Elshawi K., Lindner M., Morresi-Hauf A., Vay C., et al. Cellular localization of EMMPRIN predicts prognosis of patients with operable lung adenocarcinoma independent from MMP-2 and MMP-9. Mod Pathol 2008, 21:1130-1138.
    • (2008) Mod Pathol , vol.21 , pp. 1130-1138
    • Sienel, W.1    Polzer, B.2    Elshawi, K.3    Lindner, M.4    Morresi-Hauf, A.5    Vay, C.6
  • 24
    • 80053640489 scopus 로고    scopus 로고
    • CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors
    • Le Floch R., Chiche J., Marchiq I., Naiken T., Ilk K., Murray C.M., et al. CD147 subunit of lactate/H+ symporters MCT1 and hypoxia-inducible MCT4 is critical for energetics and growth of glycolytic tumors. Proc Natl Acad Sci USA 2011, 108:16663-16668.
    • (2011) Proc Natl Acad Sci USA , vol.108 , pp. 16663-16668
    • Le Floch, R.1    Chiche, J.2    Marchiq, I.3    Naiken, T.4    Ilk, K.5    Murray, C.M.6
  • 25
    • 65349095566 scopus 로고    scopus 로고
    • GLUT1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis
    • Amann T., Maegdefrau U., Hartmann A., Agaimy A., Marienhagen J., Weiss T.S., et al. GLUT1 expression is increased in hepatocellular carcinoma and promotes tumorigenesis. Am J Pathol 2009, 174:1544-1552.
    • (2009) Am J Pathol , vol.174 , pp. 1544-1552
    • Amann, T.1    Maegdefrau, U.2    Hartmann, A.3    Agaimy, A.4    Marienhagen, J.5    Weiss, T.S.6
  • 26
    • 70349331678 scopus 로고    scopus 로고
    • Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells
    • Yun J., Rago C., Cheong I., Pagliarini R., Angenendt P., Rajagopalan H., et al. Glucose deprivation contributes to the development of KRAS pathway mutations in tumor cells. Science 2009, 325:1555-1559.
    • (2009) Science , vol.325 , pp. 1555-1559
    • Yun, J.1    Rago, C.2    Cheong, I.3    Pagliarini, R.4    Angenendt, P.5    Rajagopalan, H.6
  • 27
    • 38549175087 scopus 로고    scopus 로고
    • Glucose transporter-1 expression in renal cell carcinoma and its correlation with hypoxia inducible factor-1 alpha
    • Lidgren A., Bergh A., Grankvist K., Rasmuson T., Ljungberg B. Glucose transporter-1 expression in renal cell carcinoma and its correlation with hypoxia inducible factor-1 alpha. BJU Int 2008, 101:480-484.
    • (2008) BJU Int , vol.101 , pp. 480-484
    • Lidgren, A.1    Bergh, A.2    Grankvist, K.3    Rasmuson, T.4    Ljungberg, B.5
  • 28
    • 79952470343 scopus 로고    scopus 로고
    • Warburg phenotype in renal cell carcinoma: high expression of glucose-transporter 1 (GLUT-1) correlates with low CD8(+) T-cell infiltration in the tumor
    • Singer K., Kastenberger M., Gottfried E., Hammerschmied C.G., Buttner M., Aigner M., et al. Warburg phenotype in renal cell carcinoma: high expression of glucose-transporter 1 (GLUT-1) correlates with low CD8(+) T-cell infiltration in the tumor. Int J Cancer 2011, 128:2085-2095.
    • (2011) Int J Cancer , vol.128 , pp. 2085-2095
    • Singer, K.1    Kastenberger, M.2    Gottfried, E.3    Hammerschmied, C.G.4    Buttner, M.5    Aigner, M.6
  • 29
    • 0034652620 scopus 로고    scopus 로고
    • High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers
    • Walenta S., Wetterling M., Lehrke M., Schwickert G., Sundfor K., Rofstad E.K., et al. High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Res 2000, 60:916-921.
    • (2000) Cancer Res , vol.60 , pp. 916-921
    • Walenta, S.1    Wetterling, M.2    Lehrke, M.3    Schwickert, G.4    Sundfor, K.5    Rofstad, E.K.6
  • 30
    • 0031029634 scopus 로고    scopus 로고
    • Correlation of high lactate levels in head and neck tumors with incidence of metastasis
    • Walenta S., Salameh A., Lyng H., Evensen J.F., Mitze M., Rofstad E.K., et al. Correlation of high lactate levels in head and neck tumors with incidence of metastasis. Am J Pathol 1997, 150:409-415.
    • (1997) Am J Pathol , vol.150 , pp. 409-415
    • Walenta, S.1    Salameh, A.2    Lyng, H.3    Evensen, J.F.4    Mitze, M.5    Rofstad, E.K.6
  • 31
    • 79954537559 scopus 로고    scopus 로고
    • Ketones and lactate increase cancer cell stemness, driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics
    • Martinez-Outschoorn U.E., Prisco M., Ertel A., Tsirigos A., Lin Z., Pavlides S., et al. Ketones and lactate increase cancer cell stemness, driving recurrence, metastasis and poor clinical outcome in breast cancer: achieving personalized medicine via Metabolo-Genomics. Cell Cycle 2011, 10:1271-1286.
    • (2011) Cell Cycle , vol.10 , pp. 1271-1286
    • Martinez-Outschoorn, U.E.1    Prisco, M.2    Ertel, A.3    Tsirigos, A.4    Lin, Z.5    Pavlides, S.6
  • 33
    • 68949092126 scopus 로고    scopus 로고
    • Lactate promotes glioma migration by TGF-beta2-dependent regulation of matrix metalloproteinase-2
    • Baumann F., Leukel P., Doerfelt A., Beier C.P., Dettmer K., Oefner P.J., et al. Lactate promotes glioma migration by TGF-beta2-dependent regulation of matrix metalloproteinase-2. Neuro Oncol 2009, 11:368-380.
    • (2009) Neuro Oncol , vol.11 , pp. 368-380
    • Baumann, F.1    Leukel, P.2    Doerfelt, A.3    Beier, C.P.4    Dettmer, K.5    Oefner, P.J.6
  • 34
    • 33745535252 scopus 로고    scopus 로고
    • Tumor microenvironment modulates hyaluronan expression: the lactate effect
    • Rudrabhatla S.R., Mahaffey C.L., Mummert M.E. Tumor microenvironment modulates hyaluronan expression: the lactate effect. J Invest Dermatol 2006, 126:1378-1387.
    • (2006) J Invest Dermatol , vol.126 , pp. 1378-1387
    • Rudrabhatla, S.R.1    Mahaffey, C.L.2    Mummert, M.E.3
  • 37
    • 0037824664 scopus 로고    scopus 로고
    • Migration of human blood dendritic cells across endothelial cell monolayers: adhesion molecules and chemokines involved in subset-specific transmigration
    • de la R.G., Longo N., Rodriguez-Fernandez J.L., Puig-Kroger A., Pineda A., Corbi A.L., et al. Migration of human blood dendritic cells across endothelial cell monolayers: adhesion molecules and chemokines involved in subset-specific transmigration. J Leukoc Biol 2003, 73:639-649.
    • (2003) J Leukoc Biol , vol.73 , pp. 639-649
    • de la, R.G.1    Longo, N.2    Rodriguez-Fernandez, J.L.3    Puig-Kroger, A.4    Pineda, A.5    Corbi, A.L.6
  • 38
    • 0031414347 scopus 로고    scopus 로고
    • Effect of bicarbonate-based dialysis solutions on intracellular pH (pHi) and TNFalpha production by peritoneal macrophages
    • Rogachev B., Hausmann M.J., Yulzari R., Weiler M., Holmes C., Faict D., et al. Effect of bicarbonate-based dialysis solutions on intracellular pH (pHi) and TNFalpha production by peritoneal macrophages. Perit Dial Int 1997, 17:546-553.
    • (1997) Perit Dial Int , vol.17 , pp. 546-553
    • Rogachev, B.1    Hausmann, M.J.2    Yulzari, R.3    Weiler, M.4    Holmes, C.5    Faict, D.6
  • 39
    • 77949324759 scopus 로고    scopus 로고
    • Lactic acid and acidification inhibit TNF secretion and glycolysis of human monocytes
    • Dietl K., Renner K., Dettmer K., Timischl B., Eberhart K., Dorn C., et al. Lactic acid and acidification inhibit TNF secretion and glycolysis of human monocytes. J Immunol 2010, 184:1200-1209.
    • (2010) J Immunol , vol.184 , pp. 1200-1209
    • Dietl, K.1    Renner, K.2    Dettmer, K.3    Timischl, B.4    Eberhart, K.5    Dorn, C.6
  • 40
    • 47249118348 scopus 로고    scopus 로고
    • Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway
    • Shime H., Yabu M., Akazawa T., Kodama K., Matsumoto M., Seya T., et al. Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway. J Immunol 2008, 180:7175-7183.
    • (2008) J Immunol , vol.180 , pp. 7175-7183
    • Shime, H.1    Yabu, M.2    Akazawa, T.3    Kodama, K.4    Matsumoto, M.5    Seya, T.6
  • 42
    • 61449221901 scopus 로고    scopus 로고
    • Lactate boosts TLR4 signaling and NF-kappaB pathway-mediated gene transcription in macrophages via monocarboxylate transporters and MD-2 up-regulation
    • Samuvel D.J., Sundararaj K.P., Nareika A., Lopes-Virella M.F., Huang Y. Lactate boosts TLR4 signaling and NF-kappaB pathway-mediated gene transcription in macrophages via monocarboxylate transporters and MD-2 up-regulation. J Immunol 2009, 182:2476-2484.
    • (2009) J Immunol , vol.182 , pp. 2476-2484
    • Samuvel, D.J.1    Sundararaj, K.P.2    Nareika, A.3    Lopes-Virella, M.F.4    Huang, Y.5
  • 43
    • 34247352844 scopus 로고    scopus 로고
    • Inhibitory effect of tumor cell-derived lactic acid on human T cells
    • Fischer K., Hoffmann P., Voelkl S., Meidenbauer N., Ammer J., Edinger M., et al. Inhibitory effect of tumor cell-derived lactic acid on human T cells. Blood 2007, 109:3812-3819.
    • (2007) Blood , vol.109 , pp. 3812-3819
    • Fischer, K.1    Hoffmann, P.2    Voelkl, S.3    Meidenbauer, N.4    Ammer, J.5    Edinger, M.6
  • 44
    • 34247233078 scopus 로고    scopus 로고
    • Multiple mechanisms underlie defective recognition of melanoma cells cultured in three-dimensional architectures by antigen-specific cytotoxic T lymphocytes
    • Feder-Mengus C., Ghosh S., Weber W.P., Wyler S., Zajac P., Terracciano L., et al. Multiple mechanisms underlie defective recognition of melanoma cells cultured in three-dimensional architectures by antigen-specific cytotoxic T lymphocytes. Br J Cancer 2007, 96:1072-1082.
    • (2007) Br J Cancer , vol.96 , pp. 1072-1082
    • Feder-Mengus, C.1    Ghosh, S.2    Weber, W.P.3    Wyler, S.4    Zajac, P.5    Terracciano, L.6
  • 46
    • 0027418622 scopus 로고
    • Transport of lactate and other monocarboxylates across mammalian plasma membranes
    • Poole R.C., Halestrap A.P. Transport of lactate and other monocarboxylates across mammalian plasma membranes. Am J Physiol 1993, 264:C761-C782.
    • (1993) Am J Physiol , vol.264
    • Poole, R.C.1    Halestrap, A.P.2
  • 47
    • 8144228566 scopus 로고    scopus 로고
    • Why do cancers have high aerobic glycolysis
    • Gatenby R.A., Gillies R.J. Why do cancers have high aerobic glycolysis. Nat Rev Cancer 2004, 4:891-899.
    • (2004) Nat Rev Cancer , vol.4 , pp. 891-899
    • Gatenby, R.A.1    Gillies, R.J.2
  • 48
    • 77951228314 scopus 로고    scopus 로고
    • The role of hypoxia and acidosis in promoting metastasis and resistance to chemotherapy
    • DeClerck K., Elble R.C. The role of hypoxia and acidosis in promoting metastasis and resistance to chemotherapy. Front Biosci 2010, 15:213-225.
    • (2010) Front Biosci , vol.15 , pp. 213-225
    • DeClerck, K.1    Elble, R.C.2
  • 50
    • 77953463274 scopus 로고    scopus 로고
    • PH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity
    • De Milito A., Canese R., Marino M.L., Borghi M., Iero M., Villa A., et al. pH-dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity. Int J Cancer 2010, 127:207-219.
    • (2010) Int J Cancer , vol.127 , pp. 207-219
    • De Milito, A.1    Canese, R.2    Marino, M.L.3    Borghi, M.4    Iero, M.5    Villa, A.6
  • 51
    • 0035881307 scopus 로고    scopus 로고
    • Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo
    • Fukumura D., Xu L., Chen Y., Gohongi T., Seed B., Jain R.K. Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo. Cancer Res 2001, 61:6020-6024.
    • (2001) Cancer Res , vol.61 , pp. 6020-6024
    • Fukumura, D.1    Xu, L.2    Chen, Y.3    Gohongi, T.4    Seed, B.5    Jain, R.K.6
  • 52
    • 0035071662 scopus 로고    scopus 로고
    • The effects of extracellular pH on immune function
    • Lardner A. The effects of extracellular pH on immune function. J Leukoc Biol 2001, 69:522-530.
    • (2001) J Leukoc Biol , vol.69 , pp. 522-530
    • Lardner, A.1
  • 53
    • 2942531063 scopus 로고    scopus 로고
    • Mitochondrial defects in cancer
    • Carew J.S., Huang P. Mitochondrial defects in cancer. Mol Cancer 2002, 1:9.
    • (2002) Mol Cancer , vol.1 , pp. 9
    • Carew, J.S.1    Huang, P.2
  • 54
    • 79955571599 scopus 로고    scopus 로고
    • Post-transcriptional regulation of the mitochondrial H(+)-ATP synthase: a key regulator of the metabolic phenotype in cancer
    • Willers I.M., Cuezva J.M. Post-transcriptional regulation of the mitochondrial H(+)-ATP synthase: a key regulator of the metabolic phenotype in cancer. Biochim Biophys Acta 2011, 1807:543-551.
    • (2011) Biochim Biophys Acta , vol.1807 , pp. 543-551
    • Willers, I.M.1    Cuezva, J.M.2
  • 55
    • 27944502154 scopus 로고    scopus 로고
    • Breast carcinomas fulfill the Warburg hypothesis and provide metabolic markers of cancer prognosis
    • Isidoro A., Casado E., Redondo A., Acebo P., Espinosa E., Alonso A.M., et al. Breast carcinomas fulfill the Warburg hypothesis and provide metabolic markers of cancer prognosis. Carcinogenesis 2005, 26:2095-2104.
    • (2005) Carcinogenesis , vol.26 , pp. 2095-2104
    • Isidoro, A.1    Casado, E.2    Redondo, A.3    Acebo, P.4    Espinosa, E.5    Alonso, A.M.6
  • 56
    • 29644448054 scopus 로고    scopus 로고
    • Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice
    • Thierbach R., Schulz T.J., Isken F., Voigt A., Mietzner B., Drewes G., et al. Targeted disruption of hepatic frataxin expression causes impaired mitochondrial function, decreased life span and tumor growth in mice. Hum Mol Genet 2005, 14:3857-3864.
    • (2005) Hum Mol Genet , vol.14 , pp. 3857-3864
    • Thierbach, R.1    Schulz, T.J.2    Isken, F.3    Voigt, A.4    Mietzner, B.5    Drewes, G.6
  • 57
    • 84855878565 scopus 로고    scopus 로고
    • P53 negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2
    • Contractor T., Harris C.R. p53 negatively regulates transcription of the pyruvate dehydrogenase kinase Pdk2. Cancer Res 2012, 72:560-567.
    • (2012) Cancer Res , vol.72 , pp. 560-567
    • Contractor, T.1    Harris, C.R.2
  • 60
    • 18544365990 scopus 로고    scopus 로고
    • Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer
    • Tomlinson I.P., Alam N.A., Rowan A.J., Barclay E., Jaeger E.E., Kelsell D., et al. Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer. Nat Genet 2002, 30:406-410.
    • (2002) Nat Genet , vol.30 , pp. 406-410
    • Tomlinson, I.P.1    Alam, N.A.2    Rowan, A.J.3    Barclay, E.4    Jaeger, E.E.5    Kelsell, D.6
  • 61
    • 9144249602 scopus 로고    scopus 로고
    • Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma
    • Vanharanta S., Buchta M., McWhinney S.R., Virta S.K., Peczkowska M., Morrison C.D., et al. Early-onset renal cell carcinoma as a novel extraparaganglial component of SDHB-associated heritable paraganglioma. Am J Hum Genet 2004, 74:153-159.
    • (2004) Am J Hum Genet , vol.74 , pp. 153-159
    • Vanharanta, S.1    Buchta, M.2    McWhinney, S.R.3    Virta, S.K.4    Peczkowska, M.5    Morrison, C.D.6
  • 62
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • Parsons D.W., Jones S., Zhang X., Lin J.C., Leary R.J., Angenendt P., et al. An integrated genomic analysis of human glioblastoma multiforme. Science 2008, 321:1807-1812.
    • (2008) Science , vol.321 , pp. 1807-1812
    • Parsons, D.W.1    Jones, S.2    Zhang, X.3    Lin, J.C.4    Leary, R.J.5    Angenendt, P.6
  • 64
    • 77955907891 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication
    • Paschka P., Schlenk R.F., Gaidzik V.I., Habdank M., Kronke J., Bullinger L., et al. IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication. J Clin Oncol 2010, 28:3636-3643.
    • (2010) J Clin Oncol , vol.28 , pp. 3636-3643
    • Paschka, P.1    Schlenk, R.F.2    Gaidzik, V.I.3    Habdank, M.4    Kronke, J.5    Bullinger, L.6
  • 65
    • 33344456073 scopus 로고    scopus 로고
    • Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted
    • Langbein S., Zerilli M., Zur H.A., Staiger W., Rensch-Boschert K., Lukan N., et al. Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted. Br J Cancer 2006, 94:578-585.
    • (2006) Br J Cancer , vol.94 , pp. 578-585
    • Langbein, S.1    Zerilli, M.2    Zur, H.A.3    Staiger, W.4    Rensch-Boschert, K.5    Lukan, N.6
  • 66
    • 45349105721 scopus 로고    scopus 로고
    • Overexpression of transketolase protein TKTL1 is associated with occurrence and progression in nasopharyngeal carcinoma: a potential therapeutic target in nasopharyngeal carcinoma
    • Zhang S., Yue J.X., Yang J.H., Cai P.C., Kong W.J. Overexpression of transketolase protein TKTL1 is associated with occurrence and progression in nasopharyngeal carcinoma: a potential therapeutic target in nasopharyngeal carcinoma. Cancer Biol Ther 2008, 7:517-522.
    • (2008) Cancer Biol Ther , vol.7 , pp. 517-522
    • Zhang, S.1    Yue, J.X.2    Yang, J.H.3    Cai, P.C.4    Kong, W.J.5
  • 67
    • 84858208795 scopus 로고    scopus 로고
    • Poor outcome in primary non-small cell lung cancers is predicted by transketolase TKTL1 expression
    • Kayser G., Sienel W., Kubitz B., Mattern D., Stickeler E., Passlick B., et al. Poor outcome in primary non-small cell lung cancers is predicted by transketolase TKTL1 expression. Pathology 2011, 43:719-724.
    • (2011) Pathology , vol.43 , pp. 719-724
    • Kayser, G.1    Sienel, W.2    Kubitz, B.3    Mattern, D.4    Stickeler, E.5    Passlick, B.6
  • 68
    • 80053206983 scopus 로고    scopus 로고
    • Transketolase-like 1 expression is modulated during colorectal cancer progression and metastasis formation
    • Diaz-Moralli S., Tarrado-Castellarnau M., Alenda C., Castells A., Cascante M. Transketolase-like 1 expression is modulated during colorectal cancer progression and metastasis formation. PLoS One 2011, 6:e25323.
    • (2011) PLoS One , vol.6
    • Diaz-Moralli, S.1    Tarrado-Castellarnau, M.2    Alenda, C.3    Castells, A.4    Cascante, M.5
  • 69
    • 77954162688 scopus 로고    scopus 로고
    • Glucose metabolism of malignant cells is not regulated by transketolase-like (TKTL)-1
    • Mayer A., von Wallbrunn A., Vaupel P. Glucose metabolism of malignant cells is not regulated by transketolase-like (TKTL)-1. Int J Oncol 2010, 37:265-271.
    • (2010) Int J Oncol , vol.37 , pp. 265-271
    • Mayer, A.1    von Wallbrunn, A.2    Vaupel, P.3
  • 70
    • 0030758923 scopus 로고    scopus 로고
    • Oxythiamine and dehydroepiandrosterone inhibit the nonoxidative synthesis of ribose and tumor cell proliferation
    • Boros L.G., Puigjaner J., Cascante M., Lee W.N., Brandes J.L., Bassilian S., et al. Oxythiamine and dehydroepiandrosterone inhibit the nonoxidative synthesis of ribose and tumor cell proliferation. Cancer Res 1997, 57:4242-4248.
    • (1997) Cancer Res , vol.57 , pp. 4242-4248
    • Boros, L.G.1    Puigjaner, J.2    Cascante, M.3    Lee, W.N.4    Brandes, J.L.5    Bassilian, S.6
  • 71
    • 0032797579 scopus 로고    scopus 로고
    • Alterations in the glycolytic and glutaminolytic pathways after malignant transformation of rat liver oval cells
    • Mazurek S., Eigenbrodt E., Failing K., Steinberg P. Alterations in the glycolytic and glutaminolytic pathways after malignant transformation of rat liver oval cells. J Cell Physiol 1999, 181:136-146.
    • (1999) J Cell Physiol , vol.181 , pp. 136-146
    • Mazurek, S.1    Eigenbrodt, E.2    Failing, K.3    Steinberg, P.4
  • 72
    • 57749088701 scopus 로고    scopus 로고
    • Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction
    • Wise D.R., DeBerardinis R.J., Mancuso A., Sayed N., Zhang X.Y., Pfeiffer H.K., et al. Myc regulates a transcriptional program that stimulates mitochondrial glutaminolysis and leads to glutamine addiction. Proc Natl Acad Sci USA 2008, 105:18782-18787.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 18782-18787
    • Wise, D.R.1    DeBerardinis, R.J.2    Mancuso, A.3    Sayed, N.4    Zhang, X.Y.5    Pfeiffer, H.K.6
  • 74
    • 0023265237 scopus 로고
    • Elevated plasma glutamate levels in colorectal carcinoma patients and in patients with acquired immunodeficiency syndrome (AIDS)
    • Droge W., Eck H.P., Betzler M., Naher H. Elevated plasma glutamate levels in colorectal carcinoma patients and in patients with acquired immunodeficiency syndrome (AIDS). Immunobiology 1987, 174:473-479.
    • (1987) Immunobiology , vol.174 , pp. 473-479
    • Droge, W.1    Eck, H.P.2    Betzler, M.3    Naher, H.4
  • 75
    • 80053112410 scopus 로고    scopus 로고
    • New role of glutamate as an immunoregulator via glutamate receptors and transporters
    • Xue H., Field C.J. New role of glutamate as an immunoregulator via glutamate receptors and transporters. Front Biosci (Schol Ed) 2011, 3:1007-1020.
    • (2011) Front Biosci (Schol Ed) , vol.3 , pp. 1007-1020
    • Xue, H.1    Field, C.J.2
  • 76
    • 0142137237 scopus 로고    scopus 로고
    • Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase
    • Uyttenhove C., Pilotte L., Theate I., Stroobant V., Colau D., Parmentier N., et al. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase. Nat Med 2003, 9:1269-1274.
    • (2003) Nat Med , vol.9 , pp. 1269-1274
    • Uyttenhove, C.1    Pilotte, L.2    Theate, I.3    Stroobant, V.4    Colau, D.5    Parmentier, N.6
  • 77
    • 54849418903 scopus 로고    scopus 로고
    • IDO1 and IDO2 are expressed in human tumors: levo- but not dextro-1-methyl tryptophan inhibits tryptophan catabolism
    • Lob S., Konigsrainer A., Zieker D., Brucher B.L., Rammensee H.G., Opelz G., et al. IDO1 and IDO2 are expressed in human tumors: levo- but not dextro-1-methyl tryptophan inhibits tryptophan catabolism. Cancer Immunol Immunother 2009, 58:153-157.
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 153-157
    • Lob, S.1    Konigsrainer, A.2    Zieker, D.3    Brucher, B.L.4    Rammensee, H.G.5    Opelz, G.6
  • 78
    • 62149114893 scopus 로고    scopus 로고
    • Nicotinamide adenine dinucleotide biology and disease
    • Penberthy W.T. Nicotinamide adenine dinucleotide biology and disease. Curr Pharm Des 2009, 15:1-2.
    • (2009) Curr Pharm Des , vol.15 , pp. 1-2
    • Penberthy, W.T.1
  • 79
    • 33845920042 scopus 로고    scopus 로고
    • Decreased serum tryptophan concentration predicts poor prognosis in malignant melanoma patients
    • Weinlich G., Murr C., Richardsen L., Winkler C., Fuchs D. Decreased serum tryptophan concentration predicts poor prognosis in malignant melanoma patients. Dermatology 2007, 214:8-14.
    • (2007) Dermatology , vol.214 , pp. 8-14
    • Weinlich, G.1    Murr, C.2    Richardsen, L.3    Winkler, C.4    Fuchs, D.5
  • 80
    • 33644775726 scopus 로고    scopus 로고
    • Prognostic value of indoleamine 2,3-dioxygenase expression in colorectal cancer: effect on tumor-infiltrating T cells
    • Brandacher G., Perathoner A., Ladurner R., Schneeberger S., Obrist P., Winkler C., et al. Prognostic value of indoleamine 2,3-dioxygenase expression in colorectal cancer: effect on tumor-infiltrating T cells. Clin Cancer Res 2006, 12:1144-1151.
    • (2006) Clin Cancer Res , vol.12 , pp. 1144-1151
    • Brandacher, G.1    Perathoner, A.2    Ladurner, R.3    Schneeberger, S.4    Obrist, P.5    Winkler, C.6
  • 81
    • 37249048334 scopus 로고    scopus 로고
    • Expression of indoleamine 2,3-dioxygenase in tumor endothelial cells correlates with long-term survival of patients with renal cell carcinoma
    • Riesenberg R., Weiler C., Spring O., Eder M., Buchner A., Popp T., et al. Expression of indoleamine 2,3-dioxygenase in tumor endothelial cells correlates with long-term survival of patients with renal cell carcinoma. Clin Cancer Res 2007, 13:6993-7002.
    • (2007) Clin Cancer Res , vol.13 , pp. 6993-7002
    • Riesenberg, R.1    Weiler, C.2    Spring, O.3    Eder, M.4    Buchner, A.5    Popp, T.6
  • 82
    • 34548604258 scopus 로고    scopus 로고
    • Adult human fibroblasts are potent immunoregulatory cells and functionally equivalent to mesenchymal stem cells
    • Haniffa M.A., Wang X.N., Holtick U., Rae M., Isaacs J.D., Dickinson A.M., et al. Adult human fibroblasts are potent immunoregulatory cells and functionally equivalent to mesenchymal stem cells. J Immunol 2007, 179:1595-1604.
    • (2007) J Immunol , vol.179 , pp. 1595-1604
    • Haniffa, M.A.1    Wang, X.N.2    Holtick, U.3    Rae, M.4    Isaacs, J.D.5    Dickinson, A.M.6
  • 84
    • 0038215374 scopus 로고    scopus 로고
    • Tolerance, DCs and tryptophan: much ado about IDO
    • Grohmann U., Fallarino F., Puccetti P. Tolerance, DCs and tryptophan: much ado about IDO. Trends Immunol 2003, 24:242-248.
    • (2003) Trends Immunol , vol.24 , pp. 242-248
    • Grohmann, U.1    Fallarino, F.2    Puccetti, P.3
  • 85
    • 84863012436 scopus 로고    scopus 로고
    • Activated CD69+ T cells foster immune privilege by regulating IDO expression in tumor-associated macrophages
    • Zhao Q., Kuang D.M., Wu Y., Xiao X., Li X.F., Li T.J., et al. Activated CD69+ T cells foster immune privilege by regulating IDO expression in tumor-associated macrophages. J Immunol 2012, 188:1117-1124.
    • (2012) J Immunol , vol.188 , pp. 1117-1124
    • Zhao, Q.1    Kuang, D.M.2    Wu, Y.3    Xiao, X.4    Li, X.F.5    Li, T.J.6
  • 86
    • 80054032526 scopus 로고    scopus 로고
    • Cancer: why tumours eat tryptophan
    • Prendergast G.C. Cancer: why tumours eat tryptophan. Nature 2011, 478:192-194.
    • (2011) Nature , vol.478 , pp. 192-194
    • Prendergast, G.C.1
  • 87
    • 33646893538 scopus 로고    scopus 로고
    • The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells
    • Fallarino F., Grohmann U., You S., McGrath B.C., Cavener D.R., Vacca C., et al. The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells. J Immunol 2006, 176:6752-6761.
    • (2006) J Immunol , vol.176 , pp. 6752-6761
    • Fallarino, F.1    Grohmann, U.2    You, S.3    McGrath, B.C.4    Cavener, D.R.5    Vacca, C.6
  • 88
    • 32944468867 scopus 로고    scopus 로고
    • Differential effects of the tryptophan metabolite 3-hydroxyanthranilic acid on the proliferation of human CD8+ T cells induced by TCR triggering or homeostatic cytokines
    • Weber W.P., Feder-Mengus C., Chiarugi A., Rosenthal R., Reschner A., Schumacher R., et al. Differential effects of the tryptophan metabolite 3-hydroxyanthranilic acid on the proliferation of human CD8+ T cells induced by TCR triggering or homeostatic cytokines. Eur J Immunol 2006, 36:296-304.
    • (2006) Eur J Immunol , vol.36 , pp. 296-304
    • Weber, W.P.1    Feder-Mengus, C.2    Chiarugi, A.3    Rosenthal, R.4    Reschner, A.5    Schumacher, R.6
  • 89
    • 67650422617 scopus 로고    scopus 로고
    • Efficacy of levo-1-methyl tryptophan and dextro-1-methyl tryptophan in reversing indoleamine-2,3-dioxygenase-mediated arrest of T-cell proliferation in human epithelial ovarian cancer
    • Qian F., Villella J., Wallace P.K., Mhawech-Fauceglia P., Tario J.D., Andrews C., et al. Efficacy of levo-1-methyl tryptophan and dextro-1-methyl tryptophan in reversing indoleamine-2,3-dioxygenase-mediated arrest of T-cell proliferation in human epithelial ovarian cancer. Cancer Res 2009, 69:5498-5504.
    • (2009) Cancer Res , vol.69 , pp. 5498-5504
    • Qian, F.1    Villella, J.2    Wallace, P.K.3    Mhawech-Fauceglia, P.4    Tario, J.D.5    Andrews, C.6
  • 90
    • 33749537279 scopus 로고    scopus 로고
    • Reinstalling antitumor immunity by inhibiting tumor-derived immunosuppressive molecule IDO through RNA interference
    • Zheng X., Koropatnick J., Li M., Zhang X., Ling F., Ren X., et al. Reinstalling antitumor immunity by inhibiting tumor-derived immunosuppressive molecule IDO through RNA interference. J Immunol 2006, 177:5639-5646.
    • (2006) J Immunol , vol.177 , pp. 5639-5646
    • Zheng, X.1    Koropatnick, J.2    Li, M.3    Zhang, X.4    Ling, F.5    Ren, X.6
  • 91
    • 59449103002 scopus 로고    scopus 로고
    • A novel cancer therapy by skin delivery of indoleamine 2,3-dioxygenase siRNA
    • Yen M.C., Lin C.C., Chen Y.L., Huang S.S., Yang H.J., Chang C.P., et al. A novel cancer therapy by skin delivery of indoleamine 2,3-dioxygenase siRNA. Clin Cancer Res 2009, 15:641-649.
    • (2009) Clin Cancer Res , vol.15 , pp. 641-649
    • Yen, M.C.1    Lin, C.C.2    Chen, Y.L.3    Huang, S.S.4    Yang, H.J.5    Chang, C.P.6
  • 92
    • 16244408626 scopus 로고    scopus 로고
    • Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy
    • Muller A.J., Duhadaway J.B., Donover P.S., Sutanto-Ward E., Prendergast G.C. Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy. Nat Med 2005, 11:312-319.
    • (2005) Nat Med , vol.11 , pp. 312-319
    • Muller, A.J.1    Duhadaway, J.B.2    Donover, P.S.3    Sutanto-Ward, E.4    Prendergast, G.C.5
  • 93
    • 47249139145 scopus 로고    scopus 로고
    • Arginase 2 is expressed by human lung cancer, but it neither induces immune suppression, nor affects disease progression
    • Rotondo R., Mastracci L., Piazza T., Barisione G., Fabbi M., Cassanello M., et al. Arginase 2 is expressed by human lung cancer, but it neither induces immune suppression, nor affects disease progression. Int J Cancer 2008, 123:1108-1116.
    • (2008) Int J Cancer , vol.123 , pp. 1108-1116
    • Rotondo, R.1    Mastracci, L.2    Piazza, T.3    Barisione, G.4    Fabbi, M.5    Cassanello, M.6
  • 94
    • 20144362409 scopus 로고    scopus 로고
    • Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity
    • Munder M., Mollinedo F., Calafat J., Canchado J., Gil-Lamaignere C., Fuentes J.M., et al. Arginase I is constitutively expressed in human granulocytes and participates in fungicidal activity. Blood 2005, 105:2549-2556.
    • (2005) Blood , vol.105 , pp. 2549-2556
    • Munder, M.1    Mollinedo, F.2    Calafat, J.3    Canchado, J.4    Gil-Lamaignere, C.5    Fuentes, J.M.6
  • 95
    • 60549088732 scopus 로고    scopus 로고
    • Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes
    • Rodriguez P.C., Ernstoff M.S., Hernandez C., Atkins M., Zabaleta J., Sierra R., et al. Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes. Cancer Res 2009, 69:1553-1560.
    • (2009) Cancer Res , vol.69 , pp. 1553-1560
    • Rodriguez, P.C.1    Ernstoff, M.S.2    Hernandez, C.3    Atkins, M.4    Zabaleta, J.5    Sierra, R.6
  • 96
    • 33846891555 scopus 로고    scopus 로고
    • Arginase, prostaglandins, and myeloid-derived suppressor cells in renal cell carcinoma
    • Ochoa A.C., Zea A.H., Hernandez C., Rodriguez P.C. Arginase, prostaglandins, and myeloid-derived suppressor cells in renal cell carcinoma. Clin Cancer Res 2007, 13:721s-726s.
    • (2007) Clin Cancer Res , vol.13
    • Ochoa, A.C.1    Zea, A.H.2    Hernandez, C.3    Rodriguez, P.C.4
  • 97
    • 20944434107 scopus 로고    scopus 로고
    • Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers
    • Bronte V., Kasic T., Gri G., Gallana K., Borsellino G., Marigo I., et al. Boosting antitumor responses of T lymphocytes infiltrating human prostate cancers. J Exp Med 2005, 201:1257-1268.
    • (2005) J Exp Med , vol.201 , pp. 1257-1268
    • Bronte, V.1    Kasic, T.2    Gri, G.3    Gallana, K.4    Borsellino, G.5    Marigo, I.6
  • 98
    • 2142695733 scopus 로고    scopus 로고
    • Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic
    • Warner T.D., Mitchell J.A. Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic. FASEB J 2004, 18:790-804.
    • (2004) FASEB J , vol.18 , pp. 790-804
    • Warner, T.D.1    Mitchell, J.A.2
  • 99
    • 4143134276 scopus 로고    scopus 로고
    • Expression of the ELAV-like protein HuR is associated with higher tumor grade and increased cyclooxygenase-2 expression in human breast carcinoma
    • Denkert C., Weichert W., Winzer K.J., Muller B.M., Noske A., Niesporek S., et al. Expression of the ELAV-like protein HuR is associated with higher tumor grade and increased cyclooxygenase-2 expression in human breast carcinoma. Clin Cancer Res 2004, 10:5580-5586.
    • (2004) Clin Cancer Res , vol.10 , pp. 5580-5586
    • Denkert, C.1    Weichert, W.2    Winzer, K.J.3    Muller, B.M.4    Noske, A.5    Niesporek, S.6
  • 100
    • 33746123520 scopus 로고    scopus 로고
    • Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia
    • Kaidi A., Qualtrough D., Williams A.C., Paraskeva C. Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia. Cancer Res 2006, 66:6683-6691.
    • (2006) Cancer Res , vol.66 , pp. 6683-6691
    • Kaidi, A.1    Qualtrough, D.2    Williams, A.C.3    Paraskeva, C.4
  • 102
    • 0037089506 scopus 로고    scopus 로고
    • Selective cyclooxygenase (COX)-1 or COX-2 inhibitors control metastatic disease in a murine model of breast cancer
    • Kundu N., Fulton A.M. Selective cyclooxygenase (COX)-1 or COX-2 inhibitors control metastatic disease in a murine model of breast cancer. Cancer Res 2002, 62:2343-2346.
    • (2002) Cancer Res , vol.62 , pp. 2343-2346
    • Kundu, N.1    Fulton, A.M.2
  • 105
    • 77956473075 scopus 로고    scopus 로고
    • COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma. Celecoxib influences MDSC function
    • Veltman J.D., Lambers M.E., van Nimwegen M., Hendriks R.W., Hoogsteden H.C., Aerts J.G., et al. COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma. Celecoxib influences MDSC function. BMC Cancer 2010, 10:464.
    • (2010) BMC Cancer , vol.10 , pp. 464
    • Veltman, J.D.1    Lambers, M.E.2    van Nimwegen, M.3    Hendriks, R.W.4    Hoogsteden, H.C.5    Aerts, J.G.6
  • 107
    • 0031933227 scopus 로고    scopus 로고
    • Ecto-enzyme and signaling functions of lymphocyte CD73
    • Resta R., Yamashita Y., Thompson L.F. Ecto-enzyme and signaling functions of lymphocyte CD73. Immunol Rev 1998, 161:95-109.
    • (1998) Immunol Rev , vol.161 , pp. 95-109
    • Resta, R.1    Yamashita, Y.2    Thompson, L.F.3
  • 108
    • 85047685683 scopus 로고    scopus 로고
    • Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia
    • Synnestvedt K., Furuta G.T., Comerford K.M., Louis N., Karhausen J., Eltzschig H.K., et al. Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. J Clin Invest 2002, 110:993-1002.
    • (2002) J Clin Invest , vol.110 , pp. 993-1002
    • Synnestvedt, K.1    Furuta, G.T.2    Comerford, K.M.3    Louis, N.4    Karhausen, J.5    Eltzschig, H.K.6
  • 109
    • 67651161862 scopus 로고    scopus 로고
    • Adenosine: an endogenous modulator of innate immune system with therapeutic potential
    • Kumar V., Sharma A. Adenosine: an endogenous modulator of innate immune system with therapeutic potential. Eur J Pharmacol 2009, 616:7-15.
    • (2009) Eur J Pharmacol , vol.616 , pp. 7-15
    • Kumar, V.1    Sharma, A.2
  • 110
    • 77957564570 scopus 로고    scopus 로고
    • Extracellular adenosine triphosphate and adenosine in cancer
    • Stagg J., Smyth M.J. Extracellular adenosine triphosphate and adenosine in cancer. Oncogene 2010, 29:5346-5358.
    • (2010) Oncogene , vol.29 , pp. 5346-5358
    • Stagg, J.1    Smyth, M.J.2
  • 111
    • 77956254094 scopus 로고    scopus 로고
    • Adenosine and prostaglandin E2 cooperate in the suppression of immune responses mediated by adaptive regulatory T cells
    • Mandapathil M., Szczepanski M.J., Szajnik M., Ren J., Jackson E.K., Johnson J.T., et al. Adenosine and prostaglandin E2 cooperate in the suppression of immune responses mediated by adaptive regulatory T cells. J Biol Chem 2010, 285:27571-27580.
    • (2010) J Biol Chem , vol.285 , pp. 27571-27580
    • Mandapathil, M.1    Szczepanski, M.J.2    Szajnik, M.3    Ren, J.4    Jackson, E.K.5    Johnson, J.T.6
  • 113
    • 84855408091 scopus 로고    scopus 로고
    • Adenosine A2B receptor blockade slows growth of bladder and breast tumors
    • Cekic C., Sag D., Li Y., Theodorescu D., Strieter R.M., Linden J. Adenosine A2B receptor blockade slows growth of bladder and breast tumors. J Immunol 2012, 188:198-205.
    • (2012) J Immunol , vol.188 , pp. 198-205
    • Cekic, C.1    Sag, D.2    Li, Y.3    Theodorescu, D.4    Strieter, R.M.5    Linden, J.6
  • 114
    • 56249134513 scopus 로고    scopus 로고
    • Quantitative analysis of 5'-deoxy-5'-methylthioadenosine in melanoma cells by liquid chromatography-stable isotope ratio tandem mass spectrometry
    • Stevens A.P., Dettmer K., Wallner S., Bosserhoff A.K., Oefner P.J. Quantitative analysis of 5'-deoxy-5'-methylthioadenosine in melanoma cells by liquid chromatography-stable isotope ratio tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci 2008, 876:123-128.
    • (2008) J Chromatogr B Analyt Technol Biomed Life Sci , vol.876 , pp. 123-128
    • Stevens, A.P.1    Dettmer, K.2    Wallner, S.3    Bosserhoff, A.K.4    Oefner, P.J.5
  • 115
    • 29744437726 scopus 로고    scopus 로고
    • Promoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma
    • Hellerbrand C., Muhlbauer M., Wallner S., Schuierer M., Behrmann I., Bataille F., et al. Promoter-hypermethylation is causing functional relevant downregulation of methylthioadenosine phosphorylase (MTAP) expression in hepatocellular carcinoma. Carcinogenesis 2006, 27:64-72.
    • (2006) Carcinogenesis , vol.27 , pp. 64-72
    • Hellerbrand, C.1    Muhlbauer, M.2    Wallner, S.3    Schuierer, M.4    Behrmann, I.5    Bataille, F.6
  • 116
    • 0042846001 scopus 로고    scopus 로고
    • Characterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanoma
    • Behrmann I., Wallner S., Komyod W., Heinrich P.C., Schuierer M., Buettner R., et al. Characterization of methylthioadenosin phosphorylase (MTAP) expression in malignant melanoma. Am J Pathol 2003, 163:683-690.
    • (2003) Am J Pathol , vol.163 , pp. 683-690
    • Behrmann, I.1    Wallner, S.2    Komyod, W.3    Heinrich, P.C.4    Schuierer, M.5    Buettner, R.6
  • 118
    • 77949967131 scopus 로고    scopus 로고
    • Targeting metabolic transformation for cancer therapy
    • Tennant D.A., Duran R.V., Gottlieb E. Targeting metabolic transformation for cancer therapy. Nat Rev Cancer 2010, 10:267-277.
    • (2010) Nat Rev Cancer , vol.10 , pp. 267-277
    • Tennant, D.A.1    Duran, R.V.2    Gottlieb, E.3
  • 119
    • 19344377474 scopus 로고    scopus 로고
    • GCN2 kinase in T-cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase
    • Munn D.H., Sharma M.D., Baban B., Harding H.P., Zhang Y., Ron D., et al. GCN2 kinase in T-cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase. Immunity 2005, 22:633-642.
    • (2005) Immunity , vol.22 , pp. 633-642
    • Munn, D.H.1    Sharma, M.D.2    Baban, B.3    Harding, H.P.4    Zhang, Y.5    Ron, D.6
  • 120
  • 121
    • 38749111823 scopus 로고    scopus 로고
    • MTOR as a target for therapy of renal cancer
    • Hudes G.R. mTOR as a target for therapy of renal cancer. Clin Adv Hematol Oncol 2007, 5:772-774.
    • (2007) Clin Adv Hematol Oncol , vol.5 , pp. 772-774
    • Hudes, G.R.1
  • 122
    • 38349092288 scopus 로고    scopus 로고
    • Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1alpha
    • Koh M.Y., Spivak-Kroizman T., Venturini S., Welsh S., Williams R.R., Kirkpatrick D.L., et al. Molecular mechanisms for the activity of PX-478, an antitumor inhibitor of the hypoxia-inducible factor-1alpha. Mol Cancer Ther 2008, 7:90-100.
    • (2008) Mol Cancer Ther , vol.7 , pp. 90-100
    • Koh, M.Y.1    Spivak-Kroizman, T.2    Venturini, S.3    Welsh, S.4    Williams, R.R.5    Kirkpatrick, D.L.6
  • 123
    • 77955656201 scopus 로고    scopus 로고
    • LW6, a novel HIF-1 inhibitor, promotes proteasomal degradation of HIF-1alpha via upregulation of VHL in a colon cancer cell line
    • Lee K., Kang J.E., Park S.K., Jin Y., Chung K.S., Kim H.M., et al. LW6, a novel HIF-1 inhibitor, promotes proteasomal degradation of HIF-1alpha via upregulation of VHL in a colon cancer cell line. Biochem Pharmacol 2010, 80:982-989.
    • (2010) Biochem Pharmacol , vol.80 , pp. 982-989
    • Lee, K.1    Kang, J.E.2    Park, S.K.3    Jin, Y.4    Chung, K.S.5    Kim, H.M.6
  • 124
    • 0042343801 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer
    • Yang J.C., Haworth L., Sherry R.M., Hwu P., Schwartzentruber D.J., Topalian S.L., et al. A randomized trial of bevacizumab, an anti-vascular endothelial growth factor antibody, for metastatic renal cancer. N Engl J Med 2003, 349:427-434.
    • (2003) N Engl J Med , vol.349 , pp. 427-434
    • Yang, J.C.1    Haworth, L.2    Sherry, R.M.3    Hwu, P.4    Schwartzentruber, D.J.5    Topalian, S.L.6
  • 125
    • 70450230486 scopus 로고    scopus 로고
    • Low doses of 2-deoxy-glucose sensitize acute lymphoblastic leukemia cells to glucocorticoid-induced apoptosis
    • Eberhart K., Renner K., Ritter I., Kastenberger M., Singer K., Hellerbrand C., et al. Low doses of 2-deoxy-glucose sensitize acute lymphoblastic leukemia cells to glucocorticoid-induced apoptosis. Leukemia 2009, 23:2167-2170.
    • (2009) Leukemia , vol.23 , pp. 2167-2170
    • Eberhart, K.1    Renner, K.2    Ritter, I.3    Kastenberger, M.4    Singer, K.5    Hellerbrand, C.6
  • 127
    • 5144225468 scopus 로고    scopus 로고
    • Imatinib (STI571)-mediated changes in glucose metabolism in human leukemia BCR-ABL-positive cells
    • Gottschalk S., Anderson N., Hainz C., Eckhardt S.G., Serkova N.J. Imatinib (STI571)-mediated changes in glucose metabolism in human leukemia BCR-ABL-positive cells. Clin Cancer Res 2004, 10:6661-6668.
    • (2004) Clin Cancer Res , vol.10 , pp. 6661-6668
    • Gottschalk, S.1    Anderson, N.2    Hainz, C.3    Eckhardt, S.G.4    Serkova, N.J.5


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