HIF1α-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

Journal of Experimental Medicine

Volumn 208, Issue 7, 2011, Pages 1367-1376

  Shi, Lewis Z ^a   Wang, Ruoning ^a   Huang, Gonghua ^a   Vogel, Peter ^a   Neale, Geoffrey ^a   Green, Douglas R ^a   Chi, Hongbo ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE 6 PHOSPHATE ISOMERASE; GLYCOLYTIC ENZYME; HEXOKINASE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; TOLL LIKE RECEPTOR 2; TRANSCRIPTION FACTOR FOXP3; TRIOSEPHOSPHATE ISOMERASE; VASCULOTROPIN; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, MOUSE; HIF1A PROTEIN, MOUSE; MTOR PROTEIN, MOUSE; PRIMER DNA; TARGET OF RAPAMYCIN KINASE;

ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; HUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; REGULATORY T LYMPHOCYTE; TH17 CELL; ALLERGIC ENCEPHALOMYELITIS; ANIMAL; C57BL MOUSE; CYTOLOGY; GENE EXPRESSION; GENETICS; GLYCOLYSIS; METABOLISM; MOUSE; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ANIMALS; BASE SEQUENCE; CELL DIFFERENTIATION; DNA PRIMERS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION; GLYCOLYSIS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, REGULATORY; TH17 CELLS; TOR SERINE-THREONINE KINASES;

EID: 79960369458     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20110278     Document Type: Article

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