Cell metabolism in the regulation of programmed cell death

Trends in Endocrinology and Metabolism

Volumn 13, Issue 2, 2002, Pages 75-78

  Plas, David R ^a   Thompson, Craig B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; PROTEIN BCL 2; PROTEIN KINASE B; GROWTH PROMOTOR; PHOSPHATIDYLINOSITOL 3 KINASE;

AKT GENE; APOPTOSIS; BCL2 GENE; BIOENERGY; CELL METABOLISM; CELL TRANSFORMATION; HUMAN; MITOCHONDRION; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; REVIEW; ANIMAL; CELL; GLYCOLYSIS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; CELLS; GLYCOLYSIS; GROWTH SUBSTANCES; HUMANS; PHOSPHORYLATION;

EID: 0036515618     PISSN: 10432760     EISSN: None     Source Type: Journal    
DOI: 10.1016/s1043-2760(01)00528-8     Document Type: Review

References (45)

1. Raff, M.C. (1992) Social controls on cell survival and cell death. Nature 356, 397-400
2. Hanahan, D. and Weinberg, R.A. (2000) The hallmarks of cancer. Cell 100, 57-70
3. Warburg, O., ed. (1931) The Metabolism of Tumours. Translated by F. Dickens, Richard P. Smith Inc.
4. Garland, J.M. and Halestrap, A. (1997) Energy metabolism during apoptosis. Bcl-2 promotes survival in hematopoietic cells induced to apoptose by growth factor withdrawal by stabilizing a form of metabolic arrest. J. Biol. Chem. 272, 4680-4688
5. Summers, S.A. and Birnbaum, M.J. (1997) A role for the serine/threonine kinase,Akt, in insulin-stimulated glucose uptake. Biochem. Soc. Trans. 25, 981-988
6. Vogt, C. et al. (1998) Effects of insulin on subcellular localization of hexokinase II in human skeletal muscle in vivo. J. Clin. Endocrinol. Metab. 83, 230-234
7. Bertrand, L. et al. (1999) Heart 6-phosphofructo-2-kinase activation by insulin results from Ser-466 and Ser-483 phosphorylation and requires 3-phosphoinositide-dependent kinase-1, but not protein kinase B. J. Biol. Chem. 274, 30927-30933
8. Lefebvre, V. et al. (1996) Signaling pathway involved in the activation of heart 6-phosphofructo-2-kinase by insulin. J. Biol. Chem. 271, 22289-22292
9. Khaled, A.R. et al. (2001) Interleukin-3 withdrawal induces an early increase in mitochondrial membrane potential unrelated to the Bcl-2 family. Roles of intracellular pH,ADP transport, and F(0)F(1)-ATPase. J. Biol. Chem. 276, 6453-6462
10. Martinou, I. et al. (1999) The release of cytochrome c from mitochondria during apoptosis of NGF-deprived sympathetic neurons is a reversible event. J. Cell Biol. 144, 883-889
11. Vander Heiden, M.G. et al. (2001) Growth factors can influence cell growth and survival through effects on glucose metabolism. Mol. Cell. Biol. 21, 5899-5912
12. Vander Heiden, M.G. et al. (2000) Outer mitochondrial membrane permeability can regulate coupled respiration and cell survival. Proc. Natl. Acad. Sci. U. S. A. 97, 4666-4671
13. Vander Heiden, M.G. et al. (1999) Bcl-xL prevents cell death following growth factor withdrawal by facilitating mitochondrial ATP/ADP exchange. Mol. Cell 3, 159-167
14. Desagher, S. and Martinou, J.C. (2000) Mitochondria as the central control point of apoptosis. Trends Cell Biol. 10, 369-377
15. Rathmell, J.C. et al. (2000) In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Mol. Cell 6, 683-692
16. Chi, M.M. et al. (2000) High insulin-like growth factor 1 (IGF-1) and insulin concentrations trigger apoptosis in the mouse blastocyst via down-regulation of the IGF-1 receptor. Endocrinology 141, 4784-4792
17. Vander Heiden, M.G. et al. (1997) Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria. Cell 91, 627-637
18. Kelekar, A. and Thompson, C.B. (1998) Bcl-2-family proteins: the role of the BH3 domain in apoptosis. Trends Cell Biol. 8, 324-330
19. Ranger, A.M. et al. (2001) Mouse models of cell death. Nat. Genet. 28, 113-118
20. Hsu, S.Y. et al. (1997) Bok is a pro-apoptotic Bcl-2 protein with restricted expression in reproductive tissues and heterodimerizes with selective anti-apoptotic Bcl-2 family members. Proc. Natl. Acad. Sci. U. S. A. 94, 12401-12406
21. Lindsten, T. et al. (2000) The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol. Cell 6, 1389-1399
22. Wei, M.C. et al. (2001) Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292, 727-730
23. Zong, W.X. et al. (2001) BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Genes Dev. 15, 1481-1486
24. Kandel, E.S. and Hay, N. (1999) The regulation and activities of the multifunctional serine/threonine kinase Akt/PKB. Exp. Cell Res. 253, 210-229
25. Blume-Jensen, P. and Hunter, T. (2001) Oncogenic kinase signalling. Nature 411, 355-365
26. Li, J. et al. (1997) PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science 275, 1943-1947
27. Jiang, B.H. et al. (2000) Phosphatidylinositol 3-kinase signaling mediates angiogenesis and expression of vascular endothelial growth factor in endothelial cells. Proc. Natl. Acad. Sci. U. S. A. 97, 1749-1753
28. Bellacosa, A. et al. (1991) A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science 254, 274-277
29. Mende, I. et al. (2001) Oncogenic transformation induced by membrane-targeted Akt2 and Akt3. Oncogene 20, 4419-4423
30. Paradis, S. and Ruvkun, G. (1998) Caenorhabditis elegans Akt/PKB transduces insulin receptor-like signals from AGE-1 PI3 kinase to the DAF-16 transcription factor. Genes Dev. 12, 2488-2498
31. Hajduch, E. et al. (2001) Protein kinase B (PKB/Akt) - A key regulator of glucose transport? FEBS Lett. 492, 199-203
32. Cho, H. et al. (2001) Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta). Science 292, 1728-1731
33. Plas, D.R. et al. (2001) Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. J. Biol. Chem. 276, 12041-12048
34. Gottlob, K et al. (2001) Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes Dev. 15, 1406-1418
35. Datta, S.R. et al. (1999) Cellular survival: a play in three Akts. Genes Dev. 13, 2905-2927
36. Datta, S.R. et al. (1997) Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91, 231-241
37. Brunet, A. et al. (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96, 857-868
38. Dijkers, P.F. et al. (2000) Expression of the proapoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr. Biol. 10, 1201-1204
39. Kane, L.P. et al. (1999) Induction of NF-kappaB by the Akt/PKB kinase. Curr. Biol. 9, 601-604
40. Ozes, O.N. et al. (1999) NF-kappaB activation by tumour necrosis factor requires the Akt serinethreonine kinase. Nature 401, 82-85
41. Romashkova, J.A. and Makarov, S.S. (1999) NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature 401, 86-90
42. Stambolic, V. et al. (1998) Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN. Cell 95, 29-39
43. Di Cristofano, A. et al. (1999) Impaired Fas response and autoimmunity in Pten+/-mice. Science 285, 2122-2125
44. Whetton, A.D. and Dexter, T.M. (1983) Effect of haematopoietic cell growth factor on intracellular ATP levels. Nature 303, 629-631
45. Whetton, A.D. et al. (1984) Haemopoietic cell growth factor mediates cell survival via its action on glucose transport. EMBO J. 3, 409-413