Overexpression of monocarboxylate anion transporter 1 and 4 in T24-induced cancer associated fibroblasts regulates the progression of bladder cancer cells in a 3D microfluidic device

Cell Cycle

Volumn 14, Issue 19, 2015, Pages 3058-3065

  Shi, Haoqing ^a,b   Jiang, Haiping ^a   Wang, Lina ^c   Cao, Yanwei ^a,b   Liu, Pengfei ^a,b   Xu, Xiaodong ^a,b   Wang, Youlin ^c   Sun, Lijiang ^a,b   Niu, Haitao ^a,b  

^a QINGDAO UNIVERSITY   (China)

^b Key Laboratory of Metabolic Diseases   (China)

^c QINGDAO UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

3D microfluidic device; Aerobic glycolysis; Bladder cancer; Cancer associated fibroblast; Co culture; Invasiveness; Lactate; Monocarboxylate anion transporter; Proliferation

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CD34 ANTIGEN; LACTIC ACID; MESSENGER RNA; MONOCARBOXYLATE TRANSPORTER 1; MONOCARBOXYLATE TRANSPORTER 4; QUERCETIN; SIMVASTATIN; COTRANSPORTER; MONOCARBOXYLATE TRANSPORT PROTEIN 1; MONOCARBOXYLATE TRANSPORTER; MUSCLE PROTEIN; SLC16A4 PROTEIN, HUMAN;

AEROBIC METABOLISM; APOPTOSIS; ARTICLE; BLADDER CANCER; BLADDER CANCER CELL LINE; CANCER ASSOCIATED FIBROBLAST; CANCER GROWTH; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; COCULTURE; CONTROLLED STUDY; CYTOKINE RELEASE; DOSE RESPONSE; DOWN REGULATION; GENE OVEREXPRESSION; GLYCOLYSIS; HUMAN; HUMAN CELL; MICROFLUIDICS; SKIN FIBROBLAST; THREE DIMENSIONAL IMAGING; TUMOR MICROENVIRONMENT; TUMOR PROMOTION; UPREGULATION; BLADDER TUMOR; CYTOLOGY; FIBROBLAST; GENETICS; LAB ON A CHIP; METABOLISM; PATHOLOGY; PHYSIOLOGY; PROCEDURES; TUMOR CELL LINE;

CELL LINE, TUMOR; COCULTURE TECHNIQUES; FIBROBLASTS; GLYCOLYSIS; HUMANS; LAB-ON-A-CHIP DEVICES; LACTIC ACID; MONOCARBOXYLIC ACID TRANSPORTERS; MUSCLE PROTEINS; SYMPORTERS; TUMOR MICROENVIRONMENT; URINARY BLADDER NEOPLASMS;

EID: 84944916889     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.1080/15384101.2015.1053666     Document Type: Article

References (35)

1. Siegel RL, Miller KD, Jemal A. Cancer statistics, 2015. CA Cancer J Clin 2015; 65:5-29; PMID:25559415
2. Airley RE, Mobasheri A. Hypoxic regulation of glucose transport, anaerobic metabolism and angiogenesis in cancer: novel pathways and targets for anticancer therapeutics. Chemotherapy 2006; 53:233-56; http://dx.doi.org/10.1159/000104457
3. Vander Heiden MG, Cantley LC, Thompson CB. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009; 324:1029-33; PMID:19460998; http://dx.doi.org/10.1126/science.1160809
4. Rivera LB, Bergers G. Targeting vascular sprouts. Science 2014; 344:1449-50; PMID:24970064; http://dx.doi.org/10.1126/science.1257071
5. Kalluri R, Zeisberg M. Fibroblasts in cancer. Nat Rev Cancer 2006; 6:392-401; PMID:16572188; http://dx.doi.org/10.1038/nrc1877
6. Ghesquière B, Wong BW, Kuchnio A, Carmeliet P. Metabolism of stromal and immune cells in health and disease. Nature 2014; 511:167-76; http://dx.doi.org/10.1038/nature13312
7. Martinez-Outschoorn UE, Balliet RM, Rivadeneira D, Chiavarina B, Pavlides S, Wang C, Whitaker-Menezes D, Daumer K, Lin Z, Witkiewicz A. Oxidative stress in cancer associated fibroblasts drives tumor-stroma coevolution: A new paradigm for understanding tumor metabolism, the field effect and genomic instability in cancer cells. Cell Cycle 2010; 9:3276-96; http://dx.doi.org/10.4161/cc.9.16.12553
8. Guido C, Whitaker-Menezes D, Lin Z, Pestell RG, Howell A, Zimmers TA, Casimiro MC, Aquila S, Ando S, Martinez-Outschoorn UE. Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth. Oncotarget 2012; 3:798; PMID:22878233
9. Rattigan YI, Patel BB, Ackerstaff E, Sukenick G, Koutcher JA, Glod JW, Banerjee D. Lactate is a mediator of metabolic cooperation between stromal carcinoma associated fibroblasts and glycolytic tumor cells in the tumor microenvironment. Exp Cell Res 2012; 318:326-35; PMID:22178238; http://dx.doi.org/10.1016/j.yexcr.2011.11.014
10. Karagiannis GS, Petraki C, Prassas I, Saraon P, Musrap N, Dimitromanolakis A, Diamandis EP. Proteomic signatures of the desmoplastic invasion front reveal collagen type XII as a marker of myofibroblastic differentiation during colorectal cancer metastasis. Oncotarget 2012; 3:267; PMID:22408128
11. Halestrap AP. The monocarboxylate transporter family—structure and functional characterization. IUBMB Life 2012; 64:1-9; PMID:22131303; http://dx.doi.org/10.1002/iub.573
12. Fiaschi T, Marini A, Giannoni E, Taddei ML, Gandellini P, De Donatis A, Lanciotti M, Serni S, Cirri P, Chiarugi P. Reciprocal metabolic reprogramming through lactate shuttle coordinately influences tumorstroma interplay. Cancer Res 2012; 72:5130-40; PMID:22850421; http://dx.doi.org/10.1158/0008-5472.CAN-12-1949
13. Végran F, Boidot R, Michiels C, Sonveaux P, Feron O. Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-kB/IL-8 pathway that drives tumor angiogenesis. Cancer Res 2011; 71:2550-60; http://dx.doi.org/10.1158/0008-5472. CAN-10-2828
14. Feron O. Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells. Radiother Oncol 2009; 92:329-33; PMID:19604589; http://dx.doi.org/10.1016/j.radonc.2009.06.025
15. Sonveaux P, Végran F, Schroeder T, Wergin MC, Verrax J, Rabbani ZN, De Saedeleer CJ, Kennedy KM, Diepart C, Jordan BF. Targeting lactate-fueled respiration selectively kills hypoxic tumor ells in mice. J Clin Invest 2008; 118:3930; PMID:19033663
16. Buess M, Nuyten D, Hastie T, Nielsen T, Pesich R, Brown PO. Characterization of heterotypic interaction effects in vitro to deconvolute global gene expression profiles in cancer. Genome Biol 2007; 8:R191; PMID:17868458
17. Giannoni E, Bianchini F, Masieri L, Serni S, Torre E, Calorini L, Chiarugi P. Reciprocal activation of prostate cancer cells and cancer-associated fibroblasts stimulates epithelial-mesenchymal transition and cancer stemness. Cancer Res 2010; 70:6945-56; PMID:20699369; http://dx.doi.org/10.1158/0008-5472.CAN-10-0785
18. Hsu T-H, Kao Y-L, Lin W-L, Xiao J-L, Kuo P-L, Wu C-W, Liao W-Y, Lee C-H. The migration speed of cancer cells influenced by macrophages and myofibroblasts co-cultured in a microfluidic chip. Integr Biol 2012; 4:177-82; PMID:22179425; http://dx.doi.org/10.1039/C2IB00112H
19. Wong AP, Perez-Castillejos R, Love JC, Whitesides GM. Partitioning microfluidic channels with hydrogel to construct tunable 3-D cellular microenvironments. Biomaterials 2008; 29:1853-61; PMID:18243301; http://dx.doi.org/10.1016/j.biomaterials.2007.12.044
20. Kaji H, Yokoi T, Kawashima T, Nishizawa M. Controlled cocultures of HeLa cells and human umbilical vein endothelial cells on detachable substrates. Lab Chip 2009; 9:427-32; PMID:19156292; http://dx.doi.org/10.1039/B812510D
21. Huang CP, Lu J, Seon H, Lee AP, Flanagan LA, Kim H-Y, Putnam AJ, Jeon NL. Engineering microscale cellular niches for three-dimensional multicellular co-cultures. Lab Chip 2009; 9:1740-8; PMID:19495458; http://dx.doi.org/10.1039/b818401a
22. Hsu TH, Xiao JL, Tsao YW, Kao YL, Huang SH, Liao WY, Lee CH. Analysis of the paracrine loop between cancer cells and fibroblasts using a microfluidic chip. Lab Chip 2011; 11:1808-14; PMID:21491053; http://dx.doi.org/10.1039/c1lc20090a
23. Morris ME, Felmlee MA. Overview of the proton-coupled MCT (SLC16A) family of transporters: characterization, function and role in the transport of the drug of abuse g-hydroxybutyric acid. AAPS J 2008; 10:311-21; PMID:18523892; http://dx.doi.org/10.1208/s12248-008-9035-6
24. Anderberg C, Pietras K. On the origin of cancer-associated fibroblasts. Cell Cycle 2009; 8:1461-5; PMID:19395855; http://dx.doi.org/10.4161/cc.8.10.8557
25. De Wever O, Mareel M. Role of tissue stroma in cancer cell invasion. J Pathol 2003; 200:429-47; PMID:12845611; http://dx.doi.org/10.1002/path.1398
26. Anderberg C, Li H, Fredriksson L, Andrae J, Betsholtz C, Li X, Eriksson U, Pietras K. Paracrine signaling by platelet-derived growth factor-CC promotes tumor growth by recruitment of cancer-associated fibroblasts. Cancer Res 2009; 69:369-78; PMID:19118022
27. Izumi H, Takahashi M, Uramoto H, Nakayama Y, Oyama T, Wang KY, Sasaguri Y, Nishizawa S, Kohno K. Monocarboxylate transporters 1 and 4 are involved in the invasion activity of human lung cancer cells. Cancer Sci 2011; 102:1007-13; PMID:21306479; http://dx.doi.org/10.1111/j.1349-7006.2011.01908.x
28. Håkanson M, Textor M, Charnley M. Engineered 3D environments to elucidate the effect of environmental parameters on drug response in cancer. Integr Biol 2011; 3:31-8; http://dx.doi.org/10.1039/C0IB00074D
29. Abbott A. Cell culture: biology’s new dimension. Nature 2003; 424:870-2; PMID:12931155; http://dx.doi.org/10.1038/424870a
30. Chaudhri VK, Salzler GG, Dick SA, Buckman MS, Sordella R, Karoly ED, Mohney R, Stiles BM, Elemento O, Altorki NK. Metabolic Alterations in lung cancer–associated fibroblasts correlated with increased glycolytic metabolism of the tumor. Mol Cancer Res 2013; 11:579-92; PMID:23475953; http://dx.doi.org/10.1158/1541-7786.MCR-12-0437-T
31. Santos AM, Jung J, Aziz N, Kissil JL, Puré E. Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice. The J Clin Invest 2009; 119:3613; PMID:19920354; http://dx.doi.org/10.1172/JCI38988
32. Pavlides S, Vera I, Gandara R, Sneddon S, Pestell RG, Mercier I, Martinez-Outschoorn UE, Whitaker- Menezes D, Howell A, Sotgia F. Warburg meets autophagy: cancer-associated fibroblasts accelerate tumor growth and metastasis via oxidative stress, mitophagy, and aerobic glycolysis. Antioxid Redox Signal 2012; 16:1264-84; PMID:21883043; http://dx.doi.org/10.1089/ars.2011.4243
33. Zhao Z, Wu MS, Zou C, Tang Q, Lu J, Liu D, Wu Y, Yin J, Xie X, Shen J. Downregulation of MCT1 inhibits tumor growth, metastasis and enhances chemotherapeutic efficacy in osteosarcoma through regulation of the NF-kB pathway. Cancer Lett 2014; 342:150-8; PMID:24012639; http://dx.doi.org/10.1016/j.canlet.2013.08.042
34. Walenta S, Wetterling M, Lehrke M, Schwickert G, Sundfør K, Rofstad EK, Mueller-Klieser W. High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Res 2000; 60:916-21; PMID:10706105
35. Tilles AW, Baskaran H, Roy P, Yarmush ML, Toner M. Effects of oxygenation and flow on the viability and function of rat hepatocytes cocultured in a microchannel flat_plate bioreactor. Biotechnol Bioeng 2001; 73:379-89; PMID:11320508; http://dx.doi.org/10.1002/bit.1071