메뉴 건너뛰기




Volumn 17, Issue 6, 2016, Pages 618-625

Immunometabolism of regulatory T cells

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A; ADENOSINE TRIPHOSPHATE; CD39 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GLUCOSE TRANSPORTER 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 2; LEPTIN; MEVALONIC ACID; MICRORNA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATE SYNTHASE; PURINERGIC P2X7 RECEPTOR; REACTIVE OXYGEN METABOLITE; SIRTUIN; SIRTUIN 1; TRANSCRIPTION FACTOR EZH2; TRANSCRIPTION FACTOR FOXO; TRANSCRIPTION FACTOR NFAT;

EID: 84970028297     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3466     Document Type: Review
Times cited : (254)

References (86)
  • 1
    • 84883679673 scopus 로고    scopus 로고
    • Peripherally induced tregs-role in immune homeostasis and autoimmunity
    • Yadav M, Stephan S, & Bluestone J.A. Peripherally induced tregs-role in immune homeostasis and autoimmunity. Front. Immunol. 4, 232 (2013).
    • (2013) Front. Immunol , vol.4 , pp. 232
    • Yadav, M.1    Stephan, S.2    Bluestone, J.A.3
  • 2
    • 84875427488 scopus 로고    scopus 로고
    • Regulatory T cells: Recommendations to simplify the nomenclature
    • Abbas A.K, et al. Regulatory T cells: recommendations to simplify the nomenclature. Nat. Immunol. 14, 307-308 (2013).
    • (2013) Nat. Immunol , vol.14 , pp. 307-308
    • Abbas, A.K.1
  • 3
    • 65549123867 scopus 로고    scopus 로고
    • Natural and adaptive foxp3+ regulatory T cells: More of the same or a division of labor?
    • Curotto de Lafaille M.A, & Lafaille J.J. Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor? Immunity. 30, 626-635 (2009).
    • (2009) Immunity , vol.30 , pp. 626-635
    • Curotto De Lafaille, M.A.1    Lafaille, J.J.2
  • 4
    • 84869148187 scopus 로고    scopus 로고
    • T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell develop-ment
    • Ohkura N, et al. T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell develop-ment. Immunity. 37, 785-799 (2012).
    • (2012) Immunity , vol.37 , pp. 785-799
    • Ohkura, N.1
  • 5
    • 27544483288 scopus 로고    scopus 로고
    • Fueling regulation: IL-2 keeps CD4+ Treg cells fit
    • Maloy K.J, & Powrie F. Fueling regulation: IL-2 keeps CD4+ Treg cells fit. Nat. Immunol. 6, 1071-1072 (2005).
    • (2005) Nat. Immunol , vol.6 , pp. 1071-1072
    • Maloy, K.J.1    Powrie, F.2
  • 6
    • 27544481941 scopus 로고    scopus 로고
    • A function for interleukin 2 in Foxp3-expressing regulatory T cells
    • Fontenot J.D, Rasmussen J.P, Gavin M.A, & Rudensky A.Y. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat. Immunol. 6, 1142-1151 (2005).
    • (2005) Nat. Immunol , vol.6 , pp. 1142-1151
    • Fontenot, J.D.1    Rasmussen, J.P.2    Gavin, M.A.3    Rudensky, A.Y.4
  • 7
    • 27544446622 scopus 로고    scopus 로고
    • Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling
    • DCruz L.M, & Klein L. Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling. Nat. Immunol. 6, 1152- 1159 (2005).
    • (2005) Nat. Immunol , vol.6 , pp. 1152-1159
    • D'Cruz, L.M.1    Klein, L.2
  • 8
    • 84903277871 scopus 로고    scopus 로고
    • Integrating canonical and metabolic signalling programmes in the regulation of T cell responses
    • Pollizzi K.N, & Powell J.D. Integrating canonical and metabolic signalling programmes in the regulation of T cell responses. Nat. Rev. Immunol. 14, 435-446 (2014).
    • (2014) Nat. Rev. Immunol , vol.14 , pp. 435-446
    • Pollizzi, K.N.1    Powell, J.D.2
  • 9
    • 84255199079 scopus 로고    scopus 로고
    • The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
    • Wang R, et al. The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity. 35, 871-882 (2011).
    • (2011) Immunity , vol.35 , pp. 871-882
    • Wang, R.1
  • 10
    • 84885670616 scopus 로고    scopus 로고
    • Fueling immunity: Insights into metabolism and lymphocyte function
    • Pearce E.L, Poffenberger M.C, Chang C.-H, & Jones R.G. Fueling immunity: insights into metabolism and lymphocyte function. Science. 342, 1242454 (2013).
    • (2013) Science , vol.342 , pp. 1242454
    • Pearce, E.L.1    Poffenberger, M.C.2    Chang, C.-H.3    Jones, R.G.4
  • 11
    • 84856183120 scopus 로고    scopus 로고
    • Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development
    • van der Windt G.J, et al. Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. Immunity. 36, 68-78 (2012).
    • (2012) Immunity , vol.36 , pp. 68-78
    • Van Der Windt, G.J.1
  • 12
    • 67650096912 scopus 로고    scopus 로고
    • Enhancing CD8 T-cell memory by modulating fatty acid metabolism
    • Pearce E.L, et al. Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature. 460, 103-107 (2009).
    • (2009) Nature , vol.460 , pp. 103-107
    • Pearce, E.L.1
  • 13
    • 79953172571 scopus 로고    scopus 로고
    • Cutting edge: Distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets
    • Michalek R.D, et al. Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J. Immunol. 186, 3299-3303 (2011).
    • (2011) J. Immunol , vol.186 , pp. 3299-3303
    • Michalek, R.D.1
  • 14
    • 84922080059 scopus 로고    scopus 로고
    • De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells
    • Berod L, et al. De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat. Med. 20, 1327-1333 (2014).
    • (2014) Nat. Med , vol.20 , pp. 1327-1333
    • Berod, L.1
  • 15
    • 84878831880 scopus 로고    scopus 로고
    • Posttranscriptional control of T cell effector function by aerobic glycolysis
    • Chang C.-H, et al. Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell. 153, 1239-1251 (2013).
    • (2013) Cell , vol.153 , pp. 1239-1251
    • Chang, C.-H.1
  • 16
    • 84920481006 scopus 로고    scopus 로고
    • Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation
    • Gerriets V.A, et al. Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. J. Clin. Invest. 125, 194-207 (2015).
    • (2015) J. Clin. Invest , vol.125 , pp. 194-207
    • Gerriets, V.A.1
  • 17
    • 79960369458 scopus 로고    scopus 로고
    • HIF1alpha-dependent glycolytic pathway orchestrates a metabolic check-point for the differentiation of TH17 and Treg cells
    • Shi L.Z, et al. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic check-point for the differentiation of TH17 and Treg cells. J. Exp. Med. 208, 1367-1376 (2011).
    • (2011) J. Exp. Med , vol.208 , pp. 1367-1376
    • Shi, L.Z.1
  • 18
    • 84881192927 scopus 로고    scopus 로고
    • MTORC1 couples immune signals and metabolic programming to estab-lish Treg-cell function
    • Zeng H, et al. mTORC1 couples immune signals and metabolic programming to estab-lish Treg-cell function. Nature. 499, 485-490 (2013).
    • (2013) Nature , vol.499 , pp. 485-490
    • Zeng, H.1
  • 19
    • 84941366350 scopus 로고    scopus 로고
    • Phosphoenolpyruvate is a metabolic checkpoint of anti-Tumor t cell responses
    • Ho P.-C, et al. Phosphoenolpyruvate is a metabolic checkpoint of anti-Tumor t cell responses. Cell. 162, 1217-1228 (2015).
    • (2015) Cell , vol.162 , pp. 1217-1228
    • Ho, P.-C.1
  • 20
    • 84945583836 scopus 로고    scopus 로고
    • Preventing allograft rejection by targeting immune metabolism
    • Lee C.-F, et al. Preventing allograft rejection by targeting immune metabolism. Cell Reports. 13, 760-770 (2015).
    • (2015) Cell Reports , vol.13 , pp. 760-770
    • Lee, C.-F.1
  • 21
    • 84960342626 scopus 로고    scopus 로고
    • The proteomic landscape of human ex vivo regulatory and conven-Tional T cells reveals specific metabolic requirements
    • Procaccini C, et al. The proteomic landscape of human ex vivo regulatory and conven-Tional T cells reveals specific metabolic requirements. Immunity. 44, 406-421 (2016).
    • (2016) Immunity , vol.44 , pp. 406-421
    • Procaccini, C.1
  • 22
    • 84942850610 scopus 로고    scopus 로고
    • Glutamine-dependent a-ketoglutarate production regulates the bal-Ance between T helper 1 cell and regulatory T cell generation
    • Klysz D, et al. Glutamine-dependent a-ketoglutarate production regulates the bal-Ance between T helper 1 cell and regulatory T cell generation. Sci. Signal. 8, ra97 (2015).
    • (2015) Sci. Signal , vol.8 , pp. ra97
    • Klysz, D.1
  • 23
    • 84876514626 scopus 로고    scopus 로고
    • Control of amino-Acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
    • Sinclair L.V, et al. Control of amino-Acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation. Nat. Immunol. 14, 500-508 (2013).
    • (2013) Nat. Immunol , vol.14 , pp. 500-508
    • Sinclair, L.V.1
  • 24
    • 84900440370 scopus 로고    scopus 로고
    • Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation
    • Nakaya M, et al. Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation. Immunity. 40, 692- 705 (2014).
    • (2014) Immunity , vol.40 , pp. 692-705
    • Nakaya, M.1
  • 25
    • 78649880396 scopus 로고    scopus 로고
    • An interaction between kynurenine and the aryl hydrocarbon recep-Tor can generate regulatory T cells
    • Mezrich J.D, et al. An interaction between kynurenine and the aryl hydrocarbon recep-Tor can generate regulatory T cells. J. Immunol. 185, 3190-3198 (2010).
    • (2010) J. Immunol , vol.185 , pp. 3190-3198
    • Mezrich, J.D.1
  • 26
    • 80054041992 scopus 로고    scopus 로고
    • An endogenous tumour-promoting ligand of the human aryl hydrocar-bon receptor
    • Opitz C.A, et al. An endogenous tumour-promoting ligand of the human aryl hydrocar-bon receptor. Nature. 478, 197-203 (2011).
    • (2011) Nature , vol.478 , pp. 197-203
    • Opitz, C.A.1
  • 27
  • 28
    • 84921390018 scopus 로고    scopus 로고
    • T-cell energy metabolism as a controller of cell fate in transplantation
    • Priyadharshini B, & Turka L.A. T-cell energy metabolism as a controller of cell fate in transplantation. Curr. Opin. Organ Transplant. 20, 21-28 (2015).
    • (2015) Curr. Opin. Organ Transplant , vol.20 , pp. 21-28
    • Priyadharshini, B.1    Turka, L.A.2
  • 29
    • 84928975351 scopus 로고    scopus 로고
    • IL-7-induced glycerol transport and TAG synthesis promotes memory CD8+ T cell longevity
    • Cui G, et al. IL-7-induced glycerol transport and TAG synthesis promotes memory CD8+ T cell longevity. Cell. 161, 750-761 (2015).
    • (2015) Cell , vol.161 , pp. 750-761
    • Cui, G.1
  • 30
    • 84904392273 scopus 로고    scopus 로고
    • Memory CD8+ T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development
    • OSullivan D, et al. Memory CD8+ T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development. Immunity. 41, 75-88 (2014).
    • (2014) Immunity , vol.41 , pp. 75-88
    • O'Sullivan, D.1
  • 31
    • 84862986986 scopus 로고    scopus 로고
    • PPAR-g is a major driver of the accumulation and phenotype of adipose tissue Treg cells
    • Cipolletta D, et al. PPAR-g is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature. 486, 549-553 (2012).
    • (2012) Nature , vol.486 , pp. 549-553
    • Cipolletta, D.1
  • 32
    • 84919634599 scopus 로고    scopus 로고
    • Metabolic control of regulatory T cell development and function
    • Zeng H, & Chi H. Metabolic control of regulatory T cell development and function. Trends Immunol. 36, 3-12 (2015).
    • (2015) Trends Immunol , vol.36 , pp. 3-12
    • Zeng, H.1    Chi, H.2
  • 33
    • 84886694563 scopus 로고    scopus 로고
    • Regulatory T cells in nonlymphoid tissues
    • Burzyn D, Benoist C, & Mathis D. Regulatory T cells in nonlymphoid tissues. Nat. Immunol. 14, 1007-1013 (2013).
    • (2013) Nat. Immunol , vol.14 , pp. 1007-1013
    • Burzyn, D.1    Benoist, C.2    Mathis, D.3
  • 34
    • 78650188983 scopus 로고    scopus 로고
    • An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness
    • Procaccini C, et al. An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness. Immunity. 33, 929-941 (2010).
    • (2010) Immunity , vol.33 , pp. 929-941
    • Procaccini, C.1
  • 36
    • 68349148211 scopus 로고    scopus 로고
    • Lean, but not obese, fat is enriched for a unique population of regula-Tory T cells that affect metabolic parameters
    • Feuerer M, et al. Lean, but not obese, fat is enriched for a unique population of regula-Tory T cells that affect metabolic parameters. Nat. Med. 15, 930-939 (2009).
    • (2009) Nat. Med , vol.15 , pp. 930-939
    • Feuerer, M.1
  • 37
    • 84890550163 scopus 로고    scopus 로고
    • Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
    • Arpaia N, et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature. 504, 451-455 (2013).
    • (2013) Nature , vol.504 , pp. 451-455
    • Arpaia, N.1
  • 38
    • 84881068658 scopus 로고    scopus 로고
    • The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis
    • Smith P.M, et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science. 341, 569-573 (2013).
    • (2013) Science , vol.341 , pp. 569-573
    • Smith, P.M.1
  • 39
    • 84890564250 scopus 로고    scopus 로고
    • Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
    • Furusawa Y, et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 504, 446-450 (2013).
    • (2013) Nature , vol.504 , pp. 446-450
    • Furusawa, Y.1
  • 40
    • 80051997049 scopus 로고    scopus 로고
    • The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function
    • Yang K, Neale G, Green D.R, He W, & Chi H. The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function. Nat. Immunol. 12, 888-897 (2011).
    • (2011) Nat. Immunol , vol.12 , pp. 888-897
    • Yang, K.1    Neale, G.2    Green, D.R.3    He, W.4    Chi, H.5
  • 41
    • 84904057246 scopus 로고    scopus 로고
    • The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function
    • Macintyre A.N, et al. The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. Cell Metab. 20, 61-72 (2014).
    • (2014) Cell Metab , vol.20 , pp. 61-72
    • Macintyre, A.N.1
  • 42
    • 67749091321 scopus 로고    scopus 로고
    • Infectious tolerance via the consumption of essential amino acids and mTOR signaling
    • Cobbold S.P, et al. Infectious tolerance via the consumption of essential amino acids and mTOR signaling. Proc. Natl. Acad. Sci. USA. 106, 12055-12060 (2009).
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 12055-12060
    • Cobbold, S.P.1
  • 43
    • 70449471819 scopus 로고    scopus 로고
    • Phosphoinositide-dependent kinase 1 controls migration and malig-nant transformation but not cell growth and proliferation in PTEN-null lymphocytes
    • Finlay D.K, et al. Phosphoinositide-dependent kinase 1 controls migration and malig-nant transformation but not cell growth and proliferation in PTEN-null lymphocytes. J. Exp. Med. 206, 2441-2454 (2009).
    • (2009) J. Exp. Med , vol.206 , pp. 2441-2454
    • Finlay, D.K.1
  • 44
    • 84921840517 scopus 로고    scopus 로고
    • Suppression of T-cell lymphomagenesis in mice requires PTEN phosphatase activity
    • Newton R.H, et al. Suppression of T-cell lymphomagenesis in mice requires PTEN phosphatase activity. Blood. 125, 852-855 (2015).
    • (2015) Blood , vol.125 , pp. 852-855
    • Newton, R.H.1
  • 45
    • 84922917657 scopus 로고    scopus 로고
    • Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability
    • Huynh A, et al. Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability. Nat. Immunol. 16, 188-196 (2015).
    • (2015) Nat. Immunol , vol.16 , pp. 188-196
    • Huynh, A.1
  • 46
    • 84884206864 scopus 로고    scopus 로고
    • Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis
    • Delgoffe G.M, et al. Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis. Nature. 501, 252-256 (2013).
    • (2013) Nature , vol.501 , pp. 252-256
    • Delgoffe, G.M.1
  • 47
    • 85002247420 scopus 로고    scopus 로고
    • The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment
    • Sharma M.D, et al. The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment. Sci Adv. 1, e1500845 (2015).
    • (2015) Sci Adv , vol.1 , pp. e1500845
    • Sharma, M.D.1
  • 48
    • 84925688346 scopus 로고    scopus 로고
    • PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
    • Patsoukis N, et al. PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation. Nat. Commun. 6, 6692 (2015).
    • (2015) Nat. Commun , vol.6 , pp. 6692
    • Patsoukis, N.1
  • 49
    • 41149113441 scopus 로고    scopus 로고
    • The AKT-mTOR axis regulates de novo dif-ferentiation of CD4+Foxp3+ cells
    • Haxhinasto S, Mathis D, & Benoist C. The AKT-mTOR axis regulates de novo dif-ferentiation of CD4+Foxp3+ cells. J. Exp. Med. 205, 565-574 (2008).
    • (2008) J. Exp. Med , vol.205 , pp. 565-574
    • Haxhinasto, S.1    Mathis, D.2    Benoist, C.3
  • 50
    • 78650085394 scopus 로고    scopus 로고
    • Foxo transcription factors control regulatory T cell development and function
    • Kerdiles Y.M, et al. Foxo transcription factors control regulatory T cell development and function. Immunity. 33, 890-904 (2010).
    • (2010) Immunity , vol.33 , pp. 890-904
    • Kerdiles, Y.M.1
  • 51
    • 77953811224 scopus 로고    scopus 로고
    • Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells
    • Ouyang W, et al. Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells. Nat. Immunol. 11, 618-627 (2010).
    • (2010) Nat. Immunol , vol.11 , pp. 618-627
    • Ouyang, W.1
  • 52
    • 84869872964 scopus 로고    scopus 로고
    • Novel Foxo1-dependent transcriptional programs control Treg cell function
    • Ouyang W, et al. Novel Foxo1-dependent transcriptional programs control Treg cell function. Nature. 491, 554-559 (2012).
    • (2012) Nature , vol.491 , pp. 554-559
    • Ouyang, W.1
  • 53
    • 84863344634 scopus 로고    scopus 로고
    • Transcription factor Foxo1 represses T-bet-mediated effector functions and promotes memory CD8+ T cell dif-ferentiation
    • Rao R.R, Li Q, Gubbels Bupp M.R, & Shrikant P.A. Transcription factor Foxo1 represses T-bet-mediated effector functions and promotes memory CD8+ T cell dif-ferentiation. Immunity. 36, 374-387 (2012).
    • (2012) Immunity , vol.36 , pp. 374-387
    • Rao, R.R.1    Li, Q.2    Gubbels Bupp, M.R.3    Shrikant, P.A.4
  • 54
    • 84879610438 scopus 로고    scopus 로고
    • FoxO1 controls effector-To-memory transition and maintenance of functional CD8 T cell memory
    • Tejera M.M, Kim E.H, Sullivan J.A, Plisch E.H, & Suresh M. FoxO1 controls effector-To-memory transition and maintenance of functional CD8 T cell memory. J. Immunol. 191, 187-199 (2013).
    • (2013) J. Immunol , vol.191 , pp. 187-199
    • Tejera, M.M.1    Kim, E.H.2    Sullivan, J.A.3    Plisch, E.H.4    Suresh, M.5
  • 55
    • 67749111502 scopus 로고    scopus 로고
    • The LKB1-AMPK pathway: Metabolism and growth control in tumour suppression
    • Shackelford D.B, & Shaw R.J. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat. Rev. Cancer. 9, 563-575 (2009).
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 563-575
    • Shackelford, D.B.1    Shaw, R.J.2
  • 56
    • 84921309472 scopus 로고    scopus 로고
    • The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo
    • Blagih J, et al. The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo. Immunity. 42, 41-54 (2015).
    • (2015) Immunity , vol.42 , pp. 41-54
    • Blagih, J.1
  • 57
    • 81055126129 scopus 로고    scopus 로고
    • Estrogen-related receptor-A is a metabolic regulator of effector T-cell activation and differentiation
    • Michalek R.D, et al. Estrogen-related receptor-A is a metabolic regulator of effector T-cell activation and differentiation. Proc. Natl. Acad. Sci. USA. 108, 18348-18353 (2011).
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 18348-18353
    • Michalek, R.D.1
  • 58
    • 84955590563 scopus 로고    scopus 로고
    • Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis
    • Wei J, et al. Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis. Nat. Immunol. 17, 277-285 (2016).
    • (2016) Nat. Immunol , vol.17 , pp. 277-285
    • Wei, J.1
  • 59
    • 84908403082 scopus 로고    scopus 로고
    • Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus
    • Feng Y, et al. Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus. Cell. 158, 749-763 (2014).
    • (2014) Cell , vol.158 , pp. 749-763
    • Feng, Y.1
  • 60
    • 84945474595 scopus 로고    scopus 로고
    • Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants
    • De Rosa V, et al. Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants. Nat. Immunol. 16, 1174-1184 (2015).
    • (2015) Nat. Immunol , vol.16 , pp. 1174-1184
    • De Rosa, V.1
  • 61
    • 80052277906 scopus 로고    scopus 로고
    • Control of TH17/Treg balance by hypoxia-inducible factor 1
    • Dang E.V, et al. Control of TH17/Treg balance by hypoxia-inducible factor 1. Cell. 146, 772-784 (2011).
    • (2011) Cell , vol.146 , pp. 772-784
    • Dang, E.V.1
  • 62
    • 84867381718 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 a-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
    • Clambey E.T, et al. Hypoxia-inducible factor-1 a-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc. Natl. Acad. Sci. USA. 109, E2784-E2793 (2012).
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. E2784-E2793
    • Clambey, E.T.1
  • 63
    • 84922999148 scopus 로고    scopus 로고
    • The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation
    • DuPage M, et al. The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation. Immunity. 42, 227-238 (2015).
    • (2015) Immunity , vol.42 , pp. 227-238
    • DuPage, M.1
  • 64
    • 84951313126 scopus 로고    scopus 로고
    • Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction
    • Zhao E, et al. Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction. Nat. Immunol. 17, 95-103 (2016).
    • (2016) Nat. Immunol , vol.17 , pp. 95-103
    • Zhao, E.1
  • 65
    • 84908401913 scopus 로고    scopus 로고
    • Function of a Foxp3 cis-element in protecting regulatory T cell identity
    • Li X, Liang Y, LeBlanc M, Benner C, & Zheng Y. Function of a Foxp3 cis-element in protecting regulatory T cell identity. Cell. 158, 734-748 (2014).
    • (2014) Cell , vol.158 , pp. 734-748
    • Li, X.1    Liang, Y.2    LeBlanc, M.3    Benner, C.4    Zheng, Y.5
  • 66
    • 84874242919 scopus 로고    scopus 로고
    • Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling
    • Sena L.A, et al. Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. Immunity. 38, 225-236 (2013).
    • (2013) Immunity , vol.38 , pp. 225-236
    • Sena, L.A.1
  • 67
    • 77649225958 scopus 로고    scopus 로고
    • Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization
    • van Loosdregt J, et al. Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization. Blood. 115, 965-974 (2010).
    • (2010) Blood , vol.115 , pp. 965-974
    • Van Loosdregt, J.1
  • 68
    • 79955438868 scopus 로고    scopus 로고
    • Rapid temporal control of Foxp3 protein degradation by sir-Tuin-1
    • van Loosdregt J, et al. Rapid temporal control of Foxp3 protein degradation by sir-Tuin-1. PLoS One. 6, e19047 (2011).
    • (2011) PLoS One , vol.6 , pp. e19047
    • Van Loosdregt, J.1
  • 69
    • 66249105703 scopus 로고    scopus 로고
    • ATP-citrate lyase links cellular metabolism to histone acetylation
    • Wellen K.E, et al. ATP-citrate lyase links cellular metabolism to histone acetylation. Science. 324, 1076-1080 (2009).
    • (2009) Science , vol.324 , pp. 1076-1080
    • Wellen, K.E.1
  • 70
    • 33847153417 scopus 로고    scopus 로고
    • Foxp3-dependent programme of regulatory T-cell differentiation
    • Gavin M.A, et al. Foxp3-dependent programme of regulatory T-cell differentiation. Nature. 445, 771-775 (2007).
    • (2007) Nature , vol.445 , pp. 771-775
    • Gavin, M.A.1
  • 71
    • 78649420520 scopus 로고    scopus 로고
    • Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway
    • Hubert S, et al. Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway. J. Exp. Med. 207, 2561-2568 (2010).
    • (2010) J. Exp. Med , vol.207 , pp. 2561-2568
    • Hubert, S.1
  • 72
    • 84956616968 scopus 로고    scopus 로고
    • Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity
    • Luo C.T, Liao W, Dadi S, Toure A, & Li M.O. Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity. Nature. 529, 532-536 (2016).
    • (2016) Nature , vol.529 , pp. 532-536
    • Luo, C.T.1    Liao, W.2    Dadi, S.3    Toure, A.4    Li, M.O.5
  • 73
    • 84885055994 scopus 로고    scopus 로고
    • Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
    • Sukumar M, et al. Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function. J. Clin. Invest. 123, 4479-4488 (2013).
    • (2013) J. Clin. Invest , vol.123 , pp. 4479-4488
    • Sukumar, M.1
  • 74
    • 84958648353 scopus 로고    scopus 로고
    • Distinct signaling of coreceptors regulates specific metabolism pathways and impacts memory development in CAR T cells
    • Kawalekar O.U, et al. Distinct signaling of coreceptors regulates specific metabolism pathways and impacts memory development in CAR T cells. Immunity. 44, 380-390 (2016).
    • (2016) Immunity , vol.44 , pp. 380-390
    • Kawalekar, O.U.1
  • 75
    • 34250351459 scopus 로고    scopus 로고
    • Adenosine generation catalyzed by CD39 and CD73 expressed on regu-latory T cells mediates immune suppression
    • Deaglio S, et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regu-latory T cells mediates immune suppression. J. Exp. Med. 204, 1257-1265 (2007).
    • (2007) J. Exp. Med , vol.204 , pp. 1257-1265
    • Deaglio, S.1
  • 76
    • 34547098277 scopus 로고    scopus 로고
    • Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: Hydrolysis of extracellular ATP and immune suppression
    • Borsellino G, et al. Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood. 110, 1225-1232 (2007).
    • (2007) Blood , vol.110 , pp. 1225-1232
    • Borsellino, G.1
  • 77
    • 84941796489 scopus 로고    scopus 로고
    • A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy
    • Leone R.D, Lo Y.C, & Powell J.D. A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy. Comput. Struct. Biotechnol. J. 13, 265-272 (2015).
    • (2015) Comput. Struct. Biotechnol. J , vol.13 , pp. 265-272
    • Leone, R.D.1    Lo, Y.C.2    Powell, J.D.3
  • 78
    • 84922930171 scopus 로고    scopus 로고
    • Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses
    • Shrestha S, et al. Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses. Nat. Immunol. 16, 178-187 (2015).
    • (2015) Nat. Immunol , vol.16 , pp. 178-187
    • Shrestha, S.1
  • 79
    • 75649122284 scopus 로고    scopus 로고
    • Dichloroacetate alleviates development of collagen II-induced arthritis in female DBA/1 mice
    • Bian L, et al. Dichloroacetate alleviates development of collagen II-induced arthritis in female DBA/1 mice. Arthritis Res. Ther. 11, R132 (2009).
    • (2009) Arthritis Res. Ther , vol.11 , pp. R132
    • Bian, L.1
  • 80
    • 35248845514 scopus 로고    scopus 로고
    • Role of IFNg in allograft tolerance mediated by CD4+CD25+ regula-Tory T cells by induction of IDO in endothelial cells
    • Thebault P, et al. Role of IFNg in allograft tolerance mediated by CD4+CD25+ regula-Tory T cells by induction of IDO in endothelial cells. Am. J. Transplant. 7, 2472-2482 (2007).
    • (2007) Am. J. Transplant , vol.7 , pp. 2472-2482
    • Thebault, P.1
  • 81
    • 66749107425 scopus 로고    scopus 로고
    • Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response
    • Sundrud M.S, et al. Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Science. 324, 1334-1338 (2009).
    • (2009) Science , vol.324 , pp. 1334-1338
    • Sundrud, M.S.1
  • 82
    • 79952274915 scopus 로고    scopus 로고
    • Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival
    • Beier U.H, et al. Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival. Mol. Cell. Biol. 31, 1022-1029 (2011).
    • (2011) Mol. Cell. Biol , vol.31 , pp. 1022-1029
    • Beier, U.H.1
  • 83
    • 35948980739 scopus 로고    scopus 로고
    • Deacetylase inhibition promotes the generation and function of regulatory T cells
    • Tao R, et al. Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat. Med. 13, 1299-1307 (2007).
    • (2007) Nat. Med , vol.13 , pp. 1299-1307
    • Tao, R.1
  • 84
    • 84860477354 scopus 로고    scopus 로고
    • SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
    • Price N.L, et al. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab. 15, 675-690 (2012).
    • (2012) Cell Metab , vol.15 , pp. 675-690
    • Price, N.L.1
  • 85
    • 79251500689 scopus 로고    scopus 로고
    • Manipulating the bioenergetics of alloreactive T cells causes their selective apoptosis and arrests graft-versus-host disease
    • Gatza E, et al. Manipulating the bioenergetics of alloreactive T cells causes their selective apoptosis and arrests graft-versus-host disease. Sci. Transl. Med. 3, 67ra8 (2011).
    • (2011) Sci. Transl. Med , vol.3 , pp. 67ra8
    • Gatza, E.1
  • 86
    • 84891607730 scopus 로고    scopus 로고
    • Effector T cells require fatty acid metabolism during murine graft-versus-host disease
    • Byersdorfer C.A, et al. Effector T cells require fatty acid metabolism during murine graft-versus-host disease. Blood. 122, 3230-3237 (2013).
    • (2013) Blood , vol.122 , pp. 3230-3237
    • Byersdorfer, C.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.