-
1
-
-
84883679673
-
Peripherally induced tregs-role in immune homeostasis and autoimmunity
-
Yadav M, Stephan S, & Bluestone J.A. Peripherally induced tregs-role in immune homeostasis and autoimmunity. Front. Immunol. 4, 232 (2013).
-
(2013)
Front. Immunol
, vol.4
, pp. 232
-
-
Yadav, M.1
Stephan, S.2
Bluestone, J.A.3
-
2
-
-
84875427488
-
Regulatory T cells: Recommendations to simplify the nomenclature
-
Abbas A.K, et al. Regulatory T cells: recommendations to simplify the nomenclature. Nat. Immunol. 14, 307-308 (2013).
-
(2013)
Nat. Immunol
, vol.14
, pp. 307-308
-
-
Abbas, A.K.1
-
3
-
-
65549123867
-
Natural and adaptive foxp3+ regulatory T cells: More of the same or a division of labor?
-
Curotto de Lafaille M.A, & Lafaille J.J. Natural and adaptive foxp3+ regulatory T cells: more of the same or a division of labor? Immunity. 30, 626-635 (2009).
-
(2009)
Immunity
, vol.30
, pp. 626-635
-
-
Curotto De Lafaille, M.A.1
Lafaille, J.J.2
-
4
-
-
84869148187
-
T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell develop-ment
-
Ohkura N, et al. T cell receptor stimulation-induced epigenetic changes and Foxp3 expression are independent and complementary events required for Treg cell develop-ment. Immunity. 37, 785-799 (2012).
-
(2012)
Immunity
, vol.37
, pp. 785-799
-
-
Ohkura, N.1
-
5
-
-
27544483288
-
Fueling regulation: IL-2 keeps CD4+ Treg cells fit
-
Maloy K.J, & Powrie F. Fueling regulation: IL-2 keeps CD4+ Treg cells fit. Nat. Immunol. 6, 1071-1072 (2005).
-
(2005)
Nat. Immunol
, vol.6
, pp. 1071-1072
-
-
Maloy, K.J.1
Powrie, F.2
-
6
-
-
27544481941
-
A function for interleukin 2 in Foxp3-expressing regulatory T cells
-
Fontenot J.D, Rasmussen J.P, Gavin M.A, & Rudensky A.Y. A function for interleukin 2 in Foxp3-expressing regulatory T cells. Nat. Immunol. 6, 1142-1151 (2005).
-
(2005)
Nat. Immunol
, vol.6
, pp. 1142-1151
-
-
Fontenot, J.D.1
Rasmussen, J.P.2
Gavin, M.A.3
Rudensky, A.Y.4
-
7
-
-
27544446622
-
Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling
-
DCruz L.M, & Klein L. Development and function of agonist-induced CD25+Foxp3+ regulatory T cells in the absence of interleukin 2 signaling. Nat. Immunol. 6, 1152- 1159 (2005).
-
(2005)
Nat. Immunol
, vol.6
, pp. 1152-1159
-
-
D'Cruz, L.M.1
Klein, L.2
-
8
-
-
84903277871
-
Integrating canonical and metabolic signalling programmes in the regulation of T cell responses
-
Pollizzi K.N, & Powell J.D. Integrating canonical and metabolic signalling programmes in the regulation of T cell responses. Nat. Rev. Immunol. 14, 435-446 (2014).
-
(2014)
Nat. Rev. Immunol
, vol.14
, pp. 435-446
-
-
Pollizzi, K.N.1
Powell, J.D.2
-
9
-
-
84255199079
-
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
-
Wang R, et al. The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity. 35, 871-882 (2011).
-
(2011)
Immunity
, vol.35
, pp. 871-882
-
-
Wang, R.1
-
10
-
-
84885670616
-
Fueling immunity: Insights into metabolism and lymphocyte function
-
Pearce E.L, Poffenberger M.C, Chang C.-H, & Jones R.G. Fueling immunity: insights into metabolism and lymphocyte function. Science. 342, 1242454 (2013).
-
(2013)
Science
, vol.342
, pp. 1242454
-
-
Pearce, E.L.1
Poffenberger, M.C.2
Chang, C.-H.3
Jones, R.G.4
-
11
-
-
84856183120
-
Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development
-
van der Windt G.J, et al. Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. Immunity. 36, 68-78 (2012).
-
(2012)
Immunity
, vol.36
, pp. 68-78
-
-
Van Der Windt, G.J.1
-
12
-
-
67650096912
-
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
-
Pearce E.L, et al. Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature. 460, 103-107 (2009).
-
(2009)
Nature
, vol.460
, pp. 103-107
-
-
Pearce, E.L.1
-
13
-
-
79953172571
-
Cutting edge: Distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets
-
Michalek R.D, et al. Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J. Immunol. 186, 3299-3303 (2011).
-
(2011)
J. Immunol
, vol.186
, pp. 3299-3303
-
-
Michalek, R.D.1
-
14
-
-
84922080059
-
De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells
-
Berod L, et al. De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat. Med. 20, 1327-1333 (2014).
-
(2014)
Nat. Med
, vol.20
, pp. 1327-1333
-
-
Berod, L.1
-
15
-
-
84878831880
-
Posttranscriptional control of T cell effector function by aerobic glycolysis
-
Chang C.-H, et al. Posttranscriptional control of T cell effector function by aerobic glycolysis. Cell. 153, 1239-1251 (2013).
-
(2013)
Cell
, vol.153
, pp. 1239-1251
-
-
Chang, C.-H.1
-
16
-
-
84920481006
-
Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation
-
Gerriets V.A, et al. Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation. J. Clin. Invest. 125, 194-207 (2015).
-
(2015)
J. Clin. Invest
, vol.125
, pp. 194-207
-
-
Gerriets, V.A.1
-
17
-
-
79960369458
-
HIF1alpha-dependent glycolytic pathway orchestrates a metabolic check-point for the differentiation of TH17 and Treg cells
-
Shi L.Z, et al. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic check-point for the differentiation of TH17 and Treg cells. J. Exp. Med. 208, 1367-1376 (2011).
-
(2011)
J. Exp. Med
, vol.208
, pp. 1367-1376
-
-
Shi, L.Z.1
-
18
-
-
84881192927
-
MTORC1 couples immune signals and metabolic programming to estab-lish Treg-cell function
-
Zeng H, et al. mTORC1 couples immune signals and metabolic programming to estab-lish Treg-cell function. Nature. 499, 485-490 (2013).
-
(2013)
Nature
, vol.499
, pp. 485-490
-
-
Zeng, H.1
-
19
-
-
84941366350
-
Phosphoenolpyruvate is a metabolic checkpoint of anti-Tumor t cell responses
-
Ho P.-C, et al. Phosphoenolpyruvate is a metabolic checkpoint of anti-Tumor t cell responses. Cell. 162, 1217-1228 (2015).
-
(2015)
Cell
, vol.162
, pp. 1217-1228
-
-
Ho, P.-C.1
-
20
-
-
84945583836
-
Preventing allograft rejection by targeting immune metabolism
-
Lee C.-F, et al. Preventing allograft rejection by targeting immune metabolism. Cell Reports. 13, 760-770 (2015).
-
(2015)
Cell Reports
, vol.13
, pp. 760-770
-
-
Lee, C.-F.1
-
21
-
-
84960342626
-
The proteomic landscape of human ex vivo regulatory and conven-Tional T cells reveals specific metabolic requirements
-
Procaccini C, et al. The proteomic landscape of human ex vivo regulatory and conven-Tional T cells reveals specific metabolic requirements. Immunity. 44, 406-421 (2016).
-
(2016)
Immunity
, vol.44
, pp. 406-421
-
-
Procaccini, C.1
-
22
-
-
84942850610
-
Glutamine-dependent a-ketoglutarate production regulates the bal-Ance between T helper 1 cell and regulatory T cell generation
-
Klysz D, et al. Glutamine-dependent a-ketoglutarate production regulates the bal-Ance between T helper 1 cell and regulatory T cell generation. Sci. Signal. 8, ra97 (2015).
-
(2015)
Sci. Signal
, vol.8
, pp. ra97
-
-
Klysz, D.1
-
23
-
-
84876514626
-
Control of amino-Acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
-
Sinclair L.V, et al. Control of amino-Acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation. Nat. Immunol. 14, 500-508 (2013).
-
(2013)
Nat. Immunol
, vol.14
, pp. 500-508
-
-
Sinclair, L.V.1
-
24
-
-
84900440370
-
Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation
-
Nakaya M, et al. Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation. Immunity. 40, 692- 705 (2014).
-
(2014)
Immunity
, vol.40
, pp. 692-705
-
-
Nakaya, M.1
-
25
-
-
78649880396
-
An interaction between kynurenine and the aryl hydrocarbon recep-Tor can generate regulatory T cells
-
Mezrich J.D, et al. An interaction between kynurenine and the aryl hydrocarbon recep-Tor can generate regulatory T cells. J. Immunol. 185, 3190-3198 (2010).
-
(2010)
J. Immunol
, vol.185
, pp. 3190-3198
-
-
Mezrich, J.D.1
-
26
-
-
80054041992
-
An endogenous tumour-promoting ligand of the human aryl hydrocar-bon receptor
-
Opitz C.A, et al. An endogenous tumour-promoting ligand of the human aryl hydrocar-bon receptor. Nature. 478, 197-203 (2011).
-
(2011)
Nature
, vol.478
, pp. 197-203
-
-
Opitz, C.A.1
-
28
-
-
84921390018
-
T-cell energy metabolism as a controller of cell fate in transplantation
-
Priyadharshini B, & Turka L.A. T-cell energy metabolism as a controller of cell fate in transplantation. Curr. Opin. Organ Transplant. 20, 21-28 (2015).
-
(2015)
Curr. Opin. Organ Transplant
, vol.20
, pp. 21-28
-
-
Priyadharshini, B.1
Turka, L.A.2
-
29
-
-
84928975351
-
IL-7-induced glycerol transport and TAG synthesis promotes memory CD8+ T cell longevity
-
Cui G, et al. IL-7-induced glycerol transport and TAG synthesis promotes memory CD8+ T cell longevity. Cell. 161, 750-761 (2015).
-
(2015)
Cell
, vol.161
, pp. 750-761
-
-
Cui, G.1
-
30
-
-
84904392273
-
Memory CD8+ T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development
-
OSullivan D, et al. Memory CD8+ T cells use cell-intrinsic lipolysis to support the metabolic programming necessary for development. Immunity. 41, 75-88 (2014).
-
(2014)
Immunity
, vol.41
, pp. 75-88
-
-
O'Sullivan, D.1
-
31
-
-
84862986986
-
PPAR-g is a major driver of the accumulation and phenotype of adipose tissue Treg cells
-
Cipolletta D, et al. PPAR-g is a major driver of the accumulation and phenotype of adipose tissue Treg cells. Nature. 486, 549-553 (2012).
-
(2012)
Nature
, vol.486
, pp. 549-553
-
-
Cipolletta, D.1
-
32
-
-
84919634599
-
Metabolic control of regulatory T cell development and function
-
Zeng H, & Chi H. Metabolic control of regulatory T cell development and function. Trends Immunol. 36, 3-12 (2015).
-
(2015)
Trends Immunol
, vol.36
, pp. 3-12
-
-
Zeng, H.1
Chi, H.2
-
33
-
-
84886694563
-
Regulatory T cells in nonlymphoid tissues
-
Burzyn D, Benoist C, & Mathis D. Regulatory T cells in nonlymphoid tissues. Nat. Immunol. 14, 1007-1013 (2013).
-
(2013)
Nat. Immunol
, vol.14
, pp. 1007-1013
-
-
Burzyn, D.1
Benoist, C.2
Mathis, D.3
-
34
-
-
78650188983
-
An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness
-
Procaccini C, et al. An oscillatory switch in mTOR kinase activity sets regulatory T cell responsiveness. Immunity. 33, 929-941 (2010).
-
(2010)
Immunity
, vol.33
, pp. 929-941
-
-
Procaccini, C.1
-
35
-
-
84855303303
-
Intracellular metabolic pathways control immune tolerance
-
Procaccini C, Galgani M, De Rosa V, & Matarese G. Intracellular metabolic pathways control immune tolerance. Trends Immunol. 33, 1-7 (2012).
-
(2012)
Trends Immunol
, vol.33
, pp. 1-7
-
-
Procaccini, C.1
Galgani, M.2
De Rosa, V.3
Matarese, G.4
-
36
-
-
68349148211
-
Lean, but not obese, fat is enriched for a unique population of regula-Tory T cells that affect metabolic parameters
-
Feuerer M, et al. Lean, but not obese, fat is enriched for a unique population of regula-Tory T cells that affect metabolic parameters. Nat. Med. 15, 930-939 (2009).
-
(2009)
Nat. Med
, vol.15
, pp. 930-939
-
-
Feuerer, M.1
-
37
-
-
84890550163
-
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
-
Arpaia N, et al. Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation. Nature. 504, 451-455 (2013).
-
(2013)
Nature
, vol.504
, pp. 451-455
-
-
Arpaia, N.1
-
38
-
-
84881068658
-
The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis
-
Smith P.M, et al. The microbial metabolites, short-chain fatty acids, regulate colonic Treg cell homeostasis. Science. 341, 569-573 (2013).
-
(2013)
Science
, vol.341
, pp. 569-573
-
-
Smith, P.M.1
-
39
-
-
84890564250
-
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
-
Furusawa Y, et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature. 504, 446-450 (2013).
-
(2013)
Nature
, vol.504
, pp. 446-450
-
-
Furusawa, Y.1
-
40
-
-
80051997049
-
The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function
-
Yang K, Neale G, Green D.R, He W, & Chi H. The tumor suppressor Tsc1 enforces quiescence of naive T cells to promote immune homeostasis and function. Nat. Immunol. 12, 888-897 (2011).
-
(2011)
Nat. Immunol
, vol.12
, pp. 888-897
-
-
Yang, K.1
Neale, G.2
Green, D.R.3
He, W.4
Chi, H.5
-
41
-
-
84904057246
-
The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function
-
Macintyre A.N, et al. The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. Cell Metab. 20, 61-72 (2014).
-
(2014)
Cell Metab
, vol.20
, pp. 61-72
-
-
Macintyre, A.N.1
-
42
-
-
67749091321
-
Infectious tolerance via the consumption of essential amino acids and mTOR signaling
-
Cobbold S.P, et al. Infectious tolerance via the consumption of essential amino acids and mTOR signaling. Proc. Natl. Acad. Sci. USA. 106, 12055-12060 (2009).
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 12055-12060
-
-
Cobbold, S.P.1
-
43
-
-
70449471819
-
Phosphoinositide-dependent kinase 1 controls migration and malig-nant transformation but not cell growth and proliferation in PTEN-null lymphocytes
-
Finlay D.K, et al. Phosphoinositide-dependent kinase 1 controls migration and malig-nant transformation but not cell growth and proliferation in PTEN-null lymphocytes. J. Exp. Med. 206, 2441-2454 (2009).
-
(2009)
J. Exp. Med
, vol.206
, pp. 2441-2454
-
-
Finlay, D.K.1
-
44
-
-
84921840517
-
Suppression of T-cell lymphomagenesis in mice requires PTEN phosphatase activity
-
Newton R.H, et al. Suppression of T-cell lymphomagenesis in mice requires PTEN phosphatase activity. Blood. 125, 852-855 (2015).
-
(2015)
Blood
, vol.125
, pp. 852-855
-
-
Newton, R.H.1
-
45
-
-
84922917657
-
Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability
-
Huynh A, et al. Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability. Nat. Immunol. 16, 188-196 (2015).
-
(2015)
Nat. Immunol
, vol.16
, pp. 188-196
-
-
Huynh, A.1
-
46
-
-
84884206864
-
Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis
-
Delgoffe G.M, et al. Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis. Nature. 501, 252-256 (2013).
-
(2013)
Nature
, vol.501
, pp. 252-256
-
-
Delgoffe, G.M.1
-
47
-
-
85002247420
-
The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment
-
Sharma M.D, et al. The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment. Sci Adv. 1, e1500845 (2015).
-
(2015)
Sci Adv
, vol.1
, pp. e1500845
-
-
Sharma, M.D.1
-
48
-
-
84925688346
-
PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation
-
Patsoukis N, et al. PD-1 alters T-cell metabolic reprogramming by inhibiting glycolysis and promoting lipolysis and fatty acid oxidation. Nat. Commun. 6, 6692 (2015).
-
(2015)
Nat. Commun
, vol.6
, pp. 6692
-
-
Patsoukis, N.1
-
49
-
-
41149113441
-
The AKT-mTOR axis regulates de novo dif-ferentiation of CD4+Foxp3+ cells
-
Haxhinasto S, Mathis D, & Benoist C. The AKT-mTOR axis regulates de novo dif-ferentiation of CD4+Foxp3+ cells. J. Exp. Med. 205, 565-574 (2008).
-
(2008)
J. Exp. Med
, vol.205
, pp. 565-574
-
-
Haxhinasto, S.1
Mathis, D.2
Benoist, C.3
-
50
-
-
78650085394
-
Foxo transcription factors control regulatory T cell development and function
-
Kerdiles Y.M, et al. Foxo transcription factors control regulatory T cell development and function. Immunity. 33, 890-904 (2010).
-
(2010)
Immunity
, vol.33
, pp. 890-904
-
-
Kerdiles, Y.M.1
-
51
-
-
77953811224
-
Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells
-
Ouyang W, et al. Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells. Nat. Immunol. 11, 618-627 (2010).
-
(2010)
Nat. Immunol
, vol.11
, pp. 618-627
-
-
Ouyang, W.1
-
52
-
-
84869872964
-
Novel Foxo1-dependent transcriptional programs control Treg cell function
-
Ouyang W, et al. Novel Foxo1-dependent transcriptional programs control Treg cell function. Nature. 491, 554-559 (2012).
-
(2012)
Nature
, vol.491
, pp. 554-559
-
-
Ouyang, W.1
-
53
-
-
84863344634
-
Transcription factor Foxo1 represses T-bet-mediated effector functions and promotes memory CD8+ T cell dif-ferentiation
-
Rao R.R, Li Q, Gubbels Bupp M.R, & Shrikant P.A. Transcription factor Foxo1 represses T-bet-mediated effector functions and promotes memory CD8+ T cell dif-ferentiation. Immunity. 36, 374-387 (2012).
-
(2012)
Immunity
, vol.36
, pp. 374-387
-
-
Rao, R.R.1
Li, Q.2
Gubbels Bupp, M.R.3
Shrikant, P.A.4
-
54
-
-
84879610438
-
FoxO1 controls effector-To-memory transition and maintenance of functional CD8 T cell memory
-
Tejera M.M, Kim E.H, Sullivan J.A, Plisch E.H, & Suresh M. FoxO1 controls effector-To-memory transition and maintenance of functional CD8 T cell memory. J. Immunol. 191, 187-199 (2013).
-
(2013)
J. Immunol
, vol.191
, pp. 187-199
-
-
Tejera, M.M.1
Kim, E.H.2
Sullivan, J.A.3
Plisch, E.H.4
Suresh, M.5
-
55
-
-
67749111502
-
The LKB1-AMPK pathway: Metabolism and growth control in tumour suppression
-
Shackelford D.B, & Shaw R.J. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat. Rev. Cancer. 9, 563-575 (2009).
-
(2009)
Nat. Rev. Cancer
, vol.9
, pp. 563-575
-
-
Shackelford, D.B.1
Shaw, R.J.2
-
56
-
-
84921309472
-
The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo
-
Blagih J, et al. The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo. Immunity. 42, 41-54 (2015).
-
(2015)
Immunity
, vol.42
, pp. 41-54
-
-
Blagih, J.1
-
57
-
-
81055126129
-
Estrogen-related receptor-A is a metabolic regulator of effector T-cell activation and differentiation
-
Michalek R.D, et al. Estrogen-related receptor-A is a metabolic regulator of effector T-cell activation and differentiation. Proc. Natl. Acad. Sci. USA. 108, 18348-18353 (2011).
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 18348-18353
-
-
Michalek, R.D.1
-
58
-
-
84955590563
-
Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis
-
Wei J, et al. Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis. Nat. Immunol. 17, 277-285 (2016).
-
(2016)
Nat. Immunol
, vol.17
, pp. 277-285
-
-
Wei, J.1
-
59
-
-
84908403082
-
Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus
-
Feng Y, et al. Control of the inheritance of regulatory T cell identity by a cis element in the Foxp3 locus. Cell. 158, 749-763 (2014).
-
(2014)
Cell
, vol.158
, pp. 749-763
-
-
Feng, Y.1
-
60
-
-
84945474595
-
Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants
-
De Rosa V, et al. Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants. Nat. Immunol. 16, 1174-1184 (2015).
-
(2015)
Nat. Immunol
, vol.16
, pp. 1174-1184
-
-
De Rosa, V.1
-
61
-
-
80052277906
-
Control of TH17/Treg balance by hypoxia-inducible factor 1
-
Dang E.V, et al. Control of TH17/Treg balance by hypoxia-inducible factor 1. Cell. 146, 772-784 (2011).
-
(2011)
Cell
, vol.146
, pp. 772-784
-
-
Dang, E.V.1
-
62
-
-
84867381718
-
Hypoxia-inducible factor-1 a-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
-
Clambey E.T, et al. Hypoxia-inducible factor-1 a-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc. Natl. Acad. Sci. USA. 109, E2784-E2793 (2012).
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. E2784-E2793
-
-
Clambey, E.T.1
-
63
-
-
84922999148
-
The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation
-
DuPage M, et al. The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation. Immunity. 42, 227-238 (2015).
-
(2015)
Immunity
, vol.42
, pp. 227-238
-
-
DuPage, M.1
-
64
-
-
84951313126
-
Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction
-
Zhao E, et al. Cancer mediates effector T cell dysfunction by targeting microRNAs and EZH2 via glycolysis restriction. Nat. Immunol. 17, 95-103 (2016).
-
(2016)
Nat. Immunol
, vol.17
, pp. 95-103
-
-
Zhao, E.1
-
65
-
-
84908401913
-
Function of a Foxp3 cis-element in protecting regulatory T cell identity
-
Li X, Liang Y, LeBlanc M, Benner C, & Zheng Y. Function of a Foxp3 cis-element in protecting regulatory T cell identity. Cell. 158, 734-748 (2014).
-
(2014)
Cell
, vol.158
, pp. 734-748
-
-
Li, X.1
Liang, Y.2
LeBlanc, M.3
Benner, C.4
Zheng, Y.5
-
66
-
-
84874242919
-
Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling
-
Sena L.A, et al. Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. Immunity. 38, 225-236 (2013).
-
(2013)
Immunity
, vol.38
, pp. 225-236
-
-
Sena, L.A.1
-
67
-
-
77649225958
-
Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization
-
van Loosdregt J, et al. Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization. Blood. 115, 965-974 (2010).
-
(2010)
Blood
, vol.115
, pp. 965-974
-
-
Van Loosdregt, J.1
-
68
-
-
79955438868
-
Rapid temporal control of Foxp3 protein degradation by sir-Tuin-1
-
van Loosdregt J, et al. Rapid temporal control of Foxp3 protein degradation by sir-Tuin-1. PLoS One. 6, e19047 (2011).
-
(2011)
PLoS One
, vol.6
, pp. e19047
-
-
Van Loosdregt, J.1
-
69
-
-
66249105703
-
ATP-citrate lyase links cellular metabolism to histone acetylation
-
Wellen K.E, et al. ATP-citrate lyase links cellular metabolism to histone acetylation. Science. 324, 1076-1080 (2009).
-
(2009)
Science
, vol.324
, pp. 1076-1080
-
-
Wellen, K.E.1
-
70
-
-
33847153417
-
Foxp3-dependent programme of regulatory T-cell differentiation
-
Gavin M.A, et al. Foxp3-dependent programme of regulatory T-cell differentiation. Nature. 445, 771-775 (2007).
-
(2007)
Nature
, vol.445
, pp. 771-775
-
-
Gavin, M.A.1
-
71
-
-
78649420520
-
Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway
-
Hubert S, et al. Extracellular NAD+ shapes the Foxp3+ regulatory T cell compartment through the ART2-P2X7 pathway. J. Exp. Med. 207, 2561-2568 (2010).
-
(2010)
J. Exp. Med
, vol.207
, pp. 2561-2568
-
-
Hubert, S.1
-
72
-
-
84956616968
-
Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity
-
Luo C.T, Liao W, Dadi S, Toure A, & Li M.O. Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity. Nature. 529, 532-536 (2016).
-
(2016)
Nature
, vol.529
, pp. 532-536
-
-
Luo, C.T.1
Liao, W.2
Dadi, S.3
Toure, A.4
Li, M.O.5
-
73
-
-
84885055994
-
Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
-
Sukumar M, et al. Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function. J. Clin. Invest. 123, 4479-4488 (2013).
-
(2013)
J. Clin. Invest
, vol.123
, pp. 4479-4488
-
-
Sukumar, M.1
-
74
-
-
84958648353
-
Distinct signaling of coreceptors regulates specific metabolism pathways and impacts memory development in CAR T cells
-
Kawalekar O.U, et al. Distinct signaling of coreceptors regulates specific metabolism pathways and impacts memory development in CAR T cells. Immunity. 44, 380-390 (2016).
-
(2016)
Immunity
, vol.44
, pp. 380-390
-
-
Kawalekar, O.U.1
-
75
-
-
34250351459
-
Adenosine generation catalyzed by CD39 and CD73 expressed on regu-latory T cells mediates immune suppression
-
Deaglio S, et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regu-latory T cells mediates immune suppression. J. Exp. Med. 204, 1257-1265 (2007).
-
(2007)
J. Exp. Med
, vol.204
, pp. 1257-1265
-
-
Deaglio, S.1
-
76
-
-
34547098277
-
Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: Hydrolysis of extracellular ATP and immune suppression
-
Borsellino G, et al. Expression of ectonucleotidase CD39 by Foxp3+ Treg cells: hydrolysis of extracellular ATP and immune suppression. Blood. 110, 1225-1232 (2007).
-
(2007)
Blood
, vol.110
, pp. 1225-1232
-
-
Borsellino, G.1
-
77
-
-
84941796489
-
A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy
-
Leone R.D, Lo Y.C, & Powell J.D. A2aR antagonists: Next generation checkpoint blockade for cancer immunotherapy. Comput. Struct. Biotechnol. J. 13, 265-272 (2015).
-
(2015)
Comput. Struct. Biotechnol. J
, vol.13
, pp. 265-272
-
-
Leone, R.D.1
Lo, Y.C.2
Powell, J.D.3
-
78
-
-
84922930171
-
Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses
-
Shrestha S, et al. Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses. Nat. Immunol. 16, 178-187 (2015).
-
(2015)
Nat. Immunol
, vol.16
, pp. 178-187
-
-
Shrestha, S.1
-
79
-
-
75649122284
-
Dichloroacetate alleviates development of collagen II-induced arthritis in female DBA/1 mice
-
Bian L, et al. Dichloroacetate alleviates development of collagen II-induced arthritis in female DBA/1 mice. Arthritis Res. Ther. 11, R132 (2009).
-
(2009)
Arthritis Res. Ther
, vol.11
, pp. R132
-
-
Bian, L.1
-
80
-
-
35248845514
-
Role of IFNg in allograft tolerance mediated by CD4+CD25+ regula-Tory T cells by induction of IDO in endothelial cells
-
Thebault P, et al. Role of IFNg in allograft tolerance mediated by CD4+CD25+ regula-Tory T cells by induction of IDO in endothelial cells. Am. J. Transplant. 7, 2472-2482 (2007).
-
(2007)
Am. J. Transplant
, vol.7
, pp. 2472-2482
-
-
Thebault, P.1
-
81
-
-
66749107425
-
Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response
-
Sundrud M.S, et al. Halofuginone inhibits TH17 cell differentiation by activating the amino acid starvation response. Science. 324, 1334-1338 (2009).
-
(2009)
Science
, vol.324
, pp. 1334-1338
-
-
Sundrud, M.S.1
-
82
-
-
79952274915
-
Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival
-
Beier U.H, et al. Sirtuin-1 targeting promotes Foxp3+ T-regulatory cell function and prolongs allograft survival. Mol. Cell. Biol. 31, 1022-1029 (2011).
-
(2011)
Mol. Cell. Biol
, vol.31
, pp. 1022-1029
-
-
Beier, U.H.1
-
83
-
-
35948980739
-
Deacetylase inhibition promotes the generation and function of regulatory T cells
-
Tao R, et al. Deacetylase inhibition promotes the generation and function of regulatory T cells. Nat. Med. 13, 1299-1307 (2007).
-
(2007)
Nat. Med
, vol.13
, pp. 1299-1307
-
-
Tao, R.1
-
84
-
-
84860477354
-
SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function
-
Price N.L, et al. SIRT1 is required for AMPK activation and the beneficial effects of resveratrol on mitochondrial function. Cell Metab. 15, 675-690 (2012).
-
(2012)
Cell Metab
, vol.15
, pp. 675-690
-
-
Price, N.L.1
-
85
-
-
79251500689
-
Manipulating the bioenergetics of alloreactive T cells causes their selective apoptosis and arrests graft-versus-host disease
-
Gatza E, et al. Manipulating the bioenergetics of alloreactive T cells causes their selective apoptosis and arrests graft-versus-host disease. Sci. Transl. Med. 3, 67ra8 (2011).
-
(2011)
Sci. Transl. Med
, vol.3
, pp. 67ra8
-
-
Gatza, E.1
-
86
-
-
84891607730
-
Effector T cells require fatty acid metabolism during murine graft-versus-host disease
-
Byersdorfer C.A, et al. Effector T cells require fatty acid metabolism during murine graft-versus-host disease. Blood. 122, 3230-3237 (2013).
-
(2013)
Blood
, vol.122
, pp. 3230-3237
-
-
Byersdorfer, C.A.1
|