메뉴 건너뛰기




Volumn 4, Issue , 2014, Pages

Beyond Warburg effect - Dual metabolic nature of cancer cells

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; LACTIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE;

EID: 84900389739     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep04927     Document Type: Article
Times cited : (166)

References (54)
  • 1
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G. & Thompson, C. B. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 7, 11-20 (2008).
    • (2008) Cell Metab , vol.7 , pp. 11-20
    • Deberardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4
  • 2
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the warburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden, M. G., Cantley, L. C. & Thompson, C. B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324, 1029-1033 (2009).
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander Heiden, M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 3
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg, O. On the origin of cancer cells. Science 123, 309-314 (1956).
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 4
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646-674.
    • Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 5
    • 66349095388 scopus 로고    scopus 로고
    • Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry
    • Hirayama, A. et al. Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry. Cancer Res 69, 4918-4925 (2009).
    • (2009) Cancer Res , vol.69 , pp. 4918-4925
    • Hirayama, A.1
  • 7
    • 8144228566 scopus 로고    scopus 로고
    • Why do cancers have high aerobic glycolysis?
    • DOI 10.1038/nrc1478
    • Gatenby, R. A. & Gillies, R. J. Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4, 891-899 (2004). (Pubitemid 39472955)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.11 , pp. 891-899
    • Gatenby, R.A.1    Gillies, R.J.2
  • 10
    • 84862800709 scopus 로고    scopus 로고
    • Central role of lactic acidosis in cancer cell resistance to glucose deprivation-induced cell death
    • Wu, H. et al. Central role of lactic acidosis in cancer cell resistance to glucose deprivation-induced cell death. J Pathol 227, 189-199 (2012).
    • (2012) J Pathol , vol.227 , pp. 189-199
    • Wu, H.1
  • 11
    • 0014082605 scopus 로고
    • The redox state of free nicotinamideadenine dinucleotide in the cytoplasm and mitochondria of rat liver
    • Williamson, D. H., Lund, P. & Krebs, H. A. The redox state of free nicotinamideadenine dinucleotide in the cytoplasm and mitochondria of rat liver. Biochem J 103, 514-527 (1967).
    • (1967) Biochem J , vol.103 , pp. 514-527
    • Williamson, D.H.1    Lund, P.2    Krebs, H.A.3
  • 12
    • 84860502652 scopus 로고    scopus 로고
    • Biochemical issues in estimation of cytosolic free NAD/NADH ratio
    • Sun, F., Dai, C., Xie, J. & Hu, X. Biochemical issues in estimation of cytosolic free NAD/NADH ratio. PLoS One 7, e34525 (2012).
    • (2012) PLoS One , vol.7
    • Sun, F.1    Dai, C.2    Xie, J.3    Hu, X.4
  • 14
    • 0033569442 scopus 로고    scopus 로고
    • The proton-linked monocarboxylate transporter (MCT) family: Structure, function and regulation
    • DOI 10.1042/0264-6021:3430281
    • Halestrap, A. P. & Price, N. T. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem J 343 Pt 2, 281-299 (1999). (Pubitemid 29511759)
    • (1999) Biochemical Journal , vol.343 , Issue.2 , pp. 281-299
    • Halestrap, A.P.1    Price, N.T.2
  • 15
    • 57449097020 scopus 로고    scopus 로고
    • Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
    • Sonveaux, P. et al. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest 118, 3930-3942 (2008).
    • (2008) J Clin Invest , vol.118 , pp. 3930-3942
    • Sonveaux, P.1
  • 16
    • 0026625436 scopus 로고
    • Buthionine sulfoximine, an experimental tool to induce glutathione deficiency: Elucidation of glutathione and ascorbate in their role as antioxidants
    • Broquist, H. P. Buthionine sulfoximine, an experimental tool to induce glutathione deficiency: elucidation of glutathione and ascorbate in their role as antioxidants. Nutr Rev 50, 110-111 (1992).
    • (1992) Nutr Rev , vol.50 , pp. 110-111
    • Broquist, H.P.1
  • 17
    • 80053506739 scopus 로고    scopus 로고
    • Enhancement of carboplatin-mediated lung cancer cell killing by simultaneous disruption of glutathione and thioredoxin metabolism
    • Fath, M. A., Ahmad, I. M., Smith, C. J., Spence, J. & Spitz, D. R. Enhancement of carboplatin-mediated lung cancer cell killing by simultaneous disruption of glutathione and thioredoxin metabolism. Clin Cancer Res 17, 6206-6217 (2011).
    • (2011) Clin Cancer Res , vol.17 , pp. 6206-6217
    • Fath, M.A.1    Ahmad, I.M.2    Smith, C.J.3    Spence, J.4    Spitz, D.R.5
  • 18
    • 0027310177 scopus 로고
    • Posttranscriptional down-regulation of ras oncogene expression by inhibitors of cellular glutathione
    • Miller, A. C., Gafner, J., Clark, E. P. & Samid, D. Posttranscriptional downregulation of ras oncogene expression by inhibitors of cellular glutathione. Mol Cell Biol 13, 4416-4422 (1993). (Pubitemid 23187671)
    • (1993) Molecular and Cellular Biology , vol.13 , Issue.7 , pp. 4416-4422
    • Miller, A.C.1    Gafner, J.2    Clark, E.P.3    Samid, D.4
  • 19
    • 34548126843 scopus 로고    scopus 로고
    • Fluorescent and luminescent probes for measurement of oxidative and nitrosative species in cells and tissues: Progress, pitfalls, and prospects
    • DOI 10.1016/j.freeradbiomed.2007.06.026, PII S0891584907004595
    • Wardman, P. Fluorescent and luminescent probes for measurement of oxidative and nitrosative species in cells and tissues: progress, pitfalls, and prospects. Free Radic Biol Med 43, 995-1022 (2007). (Pubitemid 47302656)
    • (2007) Free Radical Biology and Medicine , vol.43 , Issue.7 , pp. 995-1022
    • Wardman, P.1
  • 20
    • 79953329777 scopus 로고    scopus 로고
    • Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NFkappaB/IL-8 pathway that drives tumor angiogenesis
    • Vegran, F., Boidot, R., Michiels, C., Sonveaux, P. & Feron, O. Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NFkappaB/IL-8 pathway that drives tumor angiogenesis. Cancer Res 71, 2550-2560 (2011).
    • (2011) Cancer Res , vol.71 , pp. 2550-2560
    • Vegran, F.1    Boidot, R.2    Michiels, C.3    Sonveaux, P.4    Feron, O.5
  • 21
    • 80053154634 scopus 로고    scopus 로고
    • Proteins as binding targets of isothiocyanates in cancer prevention
    • Mi, L., Di Pasqua, A. J. & Chung, F. L. Proteins as binding targets of isothiocyanates in cancer prevention. Carcinogenesis 32, 1405-1413 (2011).
    • (2011) Carcinogenesis , vol.32 , pp. 1405-1413
    • Mi, L.1    Di Pasqua, A.J.2    Chung, F.L.3
  • 22
    • 58149157900 scopus 로고    scopus 로고
    • The genomic analysis of lactic acidosis and acidosis response in human cancers
    • Chen, J. L. et al. The genomic analysis of lactic acidosis and acidosis response in human cancers. PLoS Genet 4, e1000293 (2008).
    • (2008) PLoS Genet , vol.4
    • Chen, J.L.1
  • 23
    • 78049415422 scopus 로고    scopus 로고
    • Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through mondoa
    • Chen, J. L. et al. Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA. PLoS Genet 6, e1001093 (2010).
    • (2010) PLoS Genet , vol.6
    • Chen, J.L.1
  • 24
    • 84877597763 scopus 로고    scopus 로고
    • Tumor environmental factors glucose deprivation and lactic acidosis induce mitotic chromosomal instability-an implication in aneuploid human tumors
    • Dai, C., Sun, F., Zhu, C. & Hu, X. Tumor environmental factors glucose deprivation and lactic acidosis induce mitotic chromosomal instability-an implication in aneuploid human tumors. PLoS One 8, e63054 (2013).
    • (2013) PLoS One , vol.8
    • Dai, C.1    Sun, F.2    Zhu, C.3    Hu, X.4
  • 25
    • 65549170684 scopus 로고    scopus 로고
    • The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion
    • Silva, A. S., Yunes, J. A., Gillies, R. J. & Gatenby, R. A. The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion. Cancer Res 69, 2677-2684 (2009).
    • (2009) Cancer Res , vol.69 , pp. 2677-2684
    • Silva, A.S.1    Yunes, J.A.2    Gillies, R.J.3    Gatenby, R.A.4
  • 26
    • 67650071137 scopus 로고    scopus 로고
    • Targeting cancer cells by ROSmediated mechanisms: A radical therapeutic approach?
    • Trachootham, D., Alexandre, J. & Huang, P. Targeting cancer cells by ROSmediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov 8, 579-591 (2009).
    • (2009) Nat Rev Drug Discov , vol.8 , pp. 579-591
    • Trachootham, D.1    Alexandre, J.2    Huang, P.3
  • 27
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • Semenza, G. L. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3, 721-732 (2003). (Pubitemid 37328811)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.10 , pp. 721-732
    • Semenza, G.L.1
  • 28
    • 34250788809 scopus 로고    scopus 로고
    • Akt/pkb signaling: Navigating downstream
    • DOI 10.1016/j.cell.2007.06.009, PII S0092867407007751
    • Manning, B. D. & Cantley, L. C. AKT/PKB signaling: navigating downstream. Cell 129, 1261-1274 (2007). (Pubitemid 46962095)
    • (2007) Cell , vol.129 , Issue.7 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 30
    • 0005763468 scopus 로고
    • Use of the pH-sensitive dye BCECF to study pH regulation in cultured human kidney proximal tubule cells
    • Bergman, J. A., McAteer, J. A., Evan, A. P. & Soleimani, M. Use of the pH-sensitive dye BCECF to study pH regulation in cultured human kidney proximal tubule cells. Journal of tissue culture methods 13, 205-209 (1991).
    • (1991) Journal of Tissue Culture Methods , vol.13 , pp. 205-209
    • Bergman, J.A.1    McAteer, J.A.2    Evan, A.P.3    Soleimani, M.4
  • 31
    • 0036449401 scopus 로고    scopus 로고
    • Monitoring intracellular pH changes in response to osmotic stress and membrane transport activity using 5- chloromethylfluorescein
    • Salvi, A., Quillan, J. M. & Sadee, W. Monitoring intracellular pH changes in response to osmotic stress and membrane transport activity using 5- chloromethylfluorescein. AAPS PharmSci 4, E21 (2002).
    • (2002) AAPS PharmSci , vol.4
    • Salvi, A.1    Quillan, J.M.2    Sadee, W.3
  • 32
    • 0018764575 scopus 로고
    • Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ
    • DOI 10.1021/bi00578a012
    • Thomas, J. A., Buchsbaum, R. N., Zimniak, A. & Racker, E. Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ. Biochemistry (Mosc) 18, 2210-2218 (1979). (Pubitemid 9191034)
    • (1979) Biochemistry , vol.18 , Issue.11 , pp. 2210-2218
    • Thomas, J.A.1    Buchsbaum, R.N.2    Zimniak, A.3    Racker, E.4
  • 33
    • 0005162157 scopus 로고
    • Alterations in glucose metabolism in chick-embryo cells transformed by rous sarcoma virus: Intracellular levels of glycolytic intermediates
    • Singh, V. N., Singh, M., August, J. T. & Horecker, B. L. Alterations in glucose metabolism in chick-embryo cells transformed by Rous sarcoma virus: intracellular levels of glycolytic intermediates. Proc Natl Acad Sci U S A 71, 4129-4132 (1974).
    • (1974) Proc Natl Acad Sci U S A , vol.71 , pp. 4129-4132
    • Singh, V.N.1    Singh, M.2    August, J.T.3    Horecker, B.L.4
  • 36
    • 0021001207 scopus 로고
    • Thermodynamic studies of the activation of rabbit muscle lactate dehydrogenase by phosphate
    • Ward, L. D. & Winzor, D. J. Thermodynamic studies of the activation of rabbit muscle lactate dehydrogenase by phosphate. Biochem J 215, 685-691 (1983).
    • (1983) Biochem J , vol.215 , pp. 685-691
    • Ward, L.D.1    Winzor, D.J.2
  • 37
    • 33745530619 scopus 로고    scopus 로고
    • Biochemical thermodynamics: Applications of mathematica
    • Alberty, R. A. Biochemical thermodynamics: applications of Mathematica. Methods Biochem Anal 48, 1-458 (2006).
    • (2006) Methods Biochem Anal , vol.48 , pp. 1-458
    • Alberty, R.A.1
  • 38
    • 41549134728 scopus 로고    scopus 로고
    • Biochemical thermodynamics under near physiological conditions
    • DOI 10.1002/bmb.20157
    • Mendez, E. Biochemical thermodynamics under near physiological conditions. Biochem Mol Biol Educ 36, 116-119 (2008). (Pubitemid 351464792)
    • (2008) Biochemistry and Molecular Biology Education , vol.36 , Issue.2 , pp. 116-119
    • Mendez, E.1
  • 40
    • 49549145537 scopus 로고
    • Thermochemistry of the reaction catalyzed by lactate dehydrogenase
    • Donnovan, L. K., Barclay, K. O. & Jespersen, N. Thermochemistry of the reaction catalyzed by lactate dehydrogenase. Thermochim Acta 11, 151-156 (1975).
    • (1975) Thermochim Acta , vol.11 , pp. 151-156
    • Donnovan, L.K.1    Barclay, K.O.2    Jespersen, N.3
  • 41
    • 25544476600 scopus 로고
    • Thermodynamics of redox reactions involving nicotinamide adenine dinucleotide
    • Rekharsky, M. V., Egorov, A. M., Gal'chenko, G. L. & Berezin, I. V. Thermodynamics of redox reactions involving nicotinamide adenine dinucleotide. Thermochim Acta 46, 89-101 (1981).
    • (1981) Thermochim Acta , vol.46 , pp. 89-101
    • Rekharsky, M.V.1    Egorov, A.M.2    Gal'chenko, G.L.3    Berezin, I.V.4
  • 42
    • 9844268087 scopus 로고
    • Studies of the phosphoglucose isomerase of schistosoma mansoni
    • Bueding, E. & Mackinnon, J. A. Studies of the phosphoglucose isomerase of Schistosoma mansoni. J Biol Chem 215, 507-513 (1955).
    • (1955) J Biol Chem , vol.215 , pp. 507-513
    • Bueding, E.1    MacKinnon, J.A.2
  • 43
    • 33748456179 scopus 로고
    • Purification and some properties of phosphorylglyceric acid mutase from rabbit skeletal muscle
    • Cowgill, R. W. & Pizer, L. I. Purification and some properties of phosphorylglyceric acid mutase from rabbit skeletal muscle. J Biol Chem 223, 885-895 (1956).
    • (1956) J Biol Chem , vol.223 , pp. 885-895
    • Cowgill, R.W.1    Pizer, L.I.2
  • 44
    • 51049089100 scopus 로고    scopus 로고
    • Phosphorylation of bad at thr-201 by JNK1 promotes glycolysis through activation of phosphofructokinase-1
    • Deng, H. et al. Phosphorylation of Bad at Thr-201 by JNK1 promotes glycolysis through activation of phosphofructokinase-1. J Biol Chem 283, 20754-20760 (2008).
    • (2008) J Biol Chem , vol.283 , pp. 20754-20760
    • Deng, H.1
  • 45
    • 0013770850 scopus 로고
    • The isolation and specific activity of rabbit-muscle glyceraldehyde phosphate dehydrogenase
    • Ferdinand, W. The isolation and specific activity of rabbit-muscle glyceraldehyde phosphate dehydrogenase. Biochem J 92, 578-585 (1964).
    • (1964) Biochem J , vol.92 , pp. 578-585
    • Ferdinand, W.1
  • 46
    • 0014690721 scopus 로고
    • Subunit structure and chemical properties of rabbit liver aldolase
    • Gracy, R. W., Lacko, A. G. & Horecker, B. L. Subunit structure and chemical properties of rabbit liver aldolase. J Biol Chem 244, 3913-3919 (1969).
    • (1969) J Biol Chem , vol.244 , pp. 3913-3919
    • Gracy, R.W.1    Lacko, A.G.2    Horecker, B.L.3
  • 47
    • 0032524663 scopus 로고    scopus 로고
    • 2 isozyme involves a cysteine residue in the intersubunit contact
    • DOI 10.1074/jbc.273.20.12227
    • Ikeda, Y. & Noguchi, T. Allosteric regulation of pyruvate kinase M2 isozyme involves a cysteine residue in the intersubunit contact. J Biol Chem 273, 12227-12233 (1998). (Pubitemid 28240587)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.20 , pp. 12227-12233
    • Ikeda, Y.1    Noguchi, T.2
  • 48
    • 0024430062 scopus 로고
    • Enolase exists in the fluid phase of cytoplasm in 3T3 cells
    • Pagliaro, L., Kerr, K. & Taylor, D. L. Enolase exists in the fluid phase of cytoplasm in 3T3 cells. J Cell Sci 94 (Pt 2), 333-342 (1989). (Pubitemid 19272967)
    • (1989) Journal of Cell Science , vol.94 , Issue.2 , pp. 333-342
    • Pagliaro, L.1    Kerr, K.2    Taylor, D.L.3
  • 49
    • 0015394088 scopus 로고
    • PH-dependence of the triose phosphate isomerase reaction
    • Plaut, B. & Knowles, J. R. pH-dependence of the triose phosphate isomerase reaction. Biochem J 129, 311-320 (1972).
    • (1972) Biochem J , vol.129 , pp. 311-320
    • Plaut, B.1    Knowles, J.R.2
  • 50
    • 0014544932 scopus 로고
    • Crystalline 3-phosphoglycerate kinase from skeletal muscle
    • Scopes, R. K. Crystalline 3-phosphoglycerate kinase from skeletal muscle. Biochem J 113, 551-554 (1969).
    • (1969) Biochem J , vol.113 , pp. 551-554
    • Scopes, R.K.1
  • 51
    • 12044255619 scopus 로고
    • Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing
    • Sekine, N. et al. Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing. J Biol Chem 269, 4895-4902 (1994).
    • (1994) J Biol Chem , vol.269 , pp. 4895-4902
    • Sekine, N.1
  • 52
    • 0014409401 scopus 로고
    • Brain hexokinase. A proposed relation between soluble-particulate distribution and activity in vivo
    • Wilson, J. E. Brain hexokinase. A proposed relation between soluble-particulate distribution and activity in vivo. J Biol Chem 243, 3640-3647 (1968).
    • (1968) J Biol Chem , vol.243 , pp. 3640-3647
    • Wilson, J.E.1
  • 53
    • 34250748014 scopus 로고    scopus 로고
    • Shikonin circumvents cancer drug resistance by induction of a necroptotic death
    • DOI 10.1158/1535-7163.MCT-06-0511
    • Han, W. et al. Shikonin circumvents cancer drug resistance by induction of a necroptotic death. Mol Cancer Ther 6, 1641-1649 (2007). (Pubitemid 46954031)
    • (2007) Molecular Cancer Therapeutics , vol.6 , Issue.5 , pp. 1641-1649
    • Han, W.1    Li, L.2    Qiu, S.3    Lu, Q.4    Pan, Q.5    Gu, Y.6    Luo, J.7    Hu, X.8
  • 54
    • 0034469418 scopus 로고    scopus 로고
    • Nontransgenic models of breast cancer
    • DOI 10.1186/bcr77
    • Heppner, G. H., Miller, F. R. & Shekhar, P. M. Nontransgenic models of breast cancer. Breast Cancer Res 2, 331-334 (2000). (Pubitemid 32223615)
    • (2000) Breast Cancer Research , vol.2 , Issue.5 , pp. 331-334
    • Heppner, G.H.1    Miller, F.R.2    Shekhar, P.V.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.