-
1
-
-
37449024702
-
The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
-
DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G. & Thompson, C. B. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 7, 11-20 (2008).
-
(2008)
Cell Metab
, vol.7
, pp. 11-20
-
-
Deberardinis, R.J.1
Lum, J.J.2
Hatzivassiliou, G.3
Thompson, C.B.4
-
2
-
-
66249108601
-
Understanding the warburg effect: The metabolic requirements of cell proliferation
-
Vander Heiden, M. G., Cantley, L. C. & Thompson, C. B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324, 1029-1033 (2009).
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
3
-
-
12444279265
-
On the origin of cancer cells
-
Warburg, O. On the origin of cancer cells. Science 123, 309-314 (1956).
-
(1956)
Science
, vol.123
, pp. 309-314
-
-
Warburg, O.1
-
4
-
-
79952284127
-
Hallmarks of cancer: The next generation
-
Hanahan, D. & Weinberg, R. A. Hallmarks of cancer: the next generation. Cell 144, 646-674.
-
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
5
-
-
66349095388
-
Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry
-
Hirayama, A. et al. Quantitative metabolome profiling of colon and stomach cancer microenvironment by capillary electrophoresis time-of-flight mass spectrometry. Cancer Res 69, 4918-4925 (2009).
-
(2009)
Cancer Res
, vol.69
, pp. 4918-4925
-
-
Hirayama, A.1
-
6
-
-
45149112158
-
13C-labelled bicarbonate
-
DOI 10.1038/nature07017, PII NATURE07017
-
Gallagher, F. A. et al. Magnetic resonance imaging of pH in vivo using hyperpolarized 13C-labelled bicarbonate. Nature 453, 940-943 (2008). (Pubitemid 351832568)
-
(2008)
Nature
, vol.453
, Issue.7197
, pp. 940-943
-
-
Gallagher, F.A.1
Kettunen, M.I.2
Day, S.E.3
Hu, D.-E.4
Ardenkjaer-Larsen, J.H.5
In 'T Zandt, R.6
Jensen, P.R.7
Karlsson, M.8
Golman, K.9
Lerche, M.H.10
Brindle, K.M.11
-
7
-
-
8144228566
-
Why do cancers have high aerobic glycolysis?
-
DOI 10.1038/nrc1478
-
Gatenby, R. A. & Gillies, R. J. Why do cancers have high aerobic glycolysis? Nat Rev Cancer 4, 891-899 (2004). (Pubitemid 39472955)
-
(2004)
Nature Reviews Cancer
, vol.4
, Issue.11
, pp. 891-899
-
-
Gatenby, R.A.1
Gillies, R.J.2
-
8
-
-
0022363421
-
PH distribution in human tumors
-
Thistlethwaite, A. J., Leeper, D. B., Moylan, D. J. 3rd & Nerlinger, R. E. pH distribution in human tumors. Int J Radiat Oncol Biol Phys 11, 1647-1652 (1985). (Pubitemid 15233627)
-
(1985)
International Journal of Radiation Oncology Biology Physics
, vol.11
, Issue.9
, pp. 1647-1652
-
-
Thistlethwaite, A.J.1
Leeper, D.B.2
Moylan III, D.J.3
Nerlinger, R.E.4
-
9
-
-
0032942766
-
1H MRSI
-
DOI 10.1002/(SICI)1522-2594(199904) 41:4<743::AID-MRM13>3.0.CO;2-Z
-
van Sluis, R. et al. In vivo imaging of extracellular pH using 1HMRSI. Magn Reson Med 41, 743-750 (1999). (Pubitemid 29205721)
-
(1999)
Magnetic Resonance in Medicine
, vol.41
, Issue.4
, pp. 743-750
-
-
Van Sluis, R.1
Bhujwalla, Z.M.2
Raghunand, N.3
Ballesteros, P.4
Alvarez, J.5
Cerdan, S.6
Galons, J.-P.7
Gillies, R.J.8
-
10
-
-
84862800709
-
Central role of lactic acidosis in cancer cell resistance to glucose deprivation-induced cell death
-
Wu, H. et al. Central role of lactic acidosis in cancer cell resistance to glucose deprivation-induced cell death. J Pathol 227, 189-199 (2012).
-
(2012)
J Pathol
, vol.227
, pp. 189-199
-
-
Wu, H.1
-
11
-
-
0014082605
-
The redox state of free nicotinamideadenine dinucleotide in the cytoplasm and mitochondria of rat liver
-
Williamson, D. H., Lund, P. & Krebs, H. A. The redox state of free nicotinamideadenine dinucleotide in the cytoplasm and mitochondria of rat liver. Biochem J 103, 514-527 (1967).
-
(1967)
Biochem J
, vol.103
, pp. 514-527
-
-
Williamson, D.H.1
Lund, P.2
Krebs, H.A.3
-
12
-
-
84860502652
-
Biochemical issues in estimation of cytosolic free NAD/NADH ratio
-
Sun, F., Dai, C., Xie, J. & Hu, X. Biochemical issues in estimation of cytosolic free NAD/NADH ratio. PLoS One 7, e34525 (2012).
-
(2012)
PLoS One
, vol.7
-
-
Sun, F.1
Dai, C.2
Xie, J.3
Hu, X.4
-
14
-
-
0033569442
-
The proton-linked monocarboxylate transporter (MCT) family: Structure, function and regulation
-
DOI 10.1042/0264-6021:3430281
-
Halestrap, A. P. & Price, N. T. The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation. Biochem J 343 Pt 2, 281-299 (1999). (Pubitemid 29511759)
-
(1999)
Biochemical Journal
, vol.343
, Issue.2
, pp. 281-299
-
-
Halestrap, A.P.1
Price, N.T.2
-
15
-
-
57449097020
-
Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice
-
Sonveaux, P. et al. Targeting lactate-fueled respiration selectively kills hypoxic tumor cells in mice. J Clin Invest 118, 3930-3942 (2008).
-
(2008)
J Clin Invest
, vol.118
, pp. 3930-3942
-
-
Sonveaux, P.1
-
16
-
-
0026625436
-
Buthionine sulfoximine, an experimental tool to induce glutathione deficiency: Elucidation of glutathione and ascorbate in their role as antioxidants
-
Broquist, H. P. Buthionine sulfoximine, an experimental tool to induce glutathione deficiency: elucidation of glutathione and ascorbate in their role as antioxidants. Nutr Rev 50, 110-111 (1992).
-
(1992)
Nutr Rev
, vol.50
, pp. 110-111
-
-
Broquist, H.P.1
-
17
-
-
80053506739
-
Enhancement of carboplatin-mediated lung cancer cell killing by simultaneous disruption of glutathione and thioredoxin metabolism
-
Fath, M. A., Ahmad, I. M., Smith, C. J., Spence, J. & Spitz, D. R. Enhancement of carboplatin-mediated lung cancer cell killing by simultaneous disruption of glutathione and thioredoxin metabolism. Clin Cancer Res 17, 6206-6217 (2011).
-
(2011)
Clin Cancer Res
, vol.17
, pp. 6206-6217
-
-
Fath, M.A.1
Ahmad, I.M.2
Smith, C.J.3
Spence, J.4
Spitz, D.R.5
-
18
-
-
0027310177
-
Posttranscriptional down-regulation of ras oncogene expression by inhibitors of cellular glutathione
-
Miller, A. C., Gafner, J., Clark, E. P. & Samid, D. Posttranscriptional downregulation of ras oncogene expression by inhibitors of cellular glutathione. Mol Cell Biol 13, 4416-4422 (1993). (Pubitemid 23187671)
-
(1993)
Molecular and Cellular Biology
, vol.13
, Issue.7
, pp. 4416-4422
-
-
Miller, A.C.1
Gafner, J.2
Clark, E.P.3
Samid, D.4
-
19
-
-
34548126843
-
Fluorescent and luminescent probes for measurement of oxidative and nitrosative species in cells and tissues: Progress, pitfalls, and prospects
-
DOI 10.1016/j.freeradbiomed.2007.06.026, PII S0891584907004595
-
Wardman, P. Fluorescent and luminescent probes for measurement of oxidative and nitrosative species in cells and tissues: progress, pitfalls, and prospects. Free Radic Biol Med 43, 995-1022 (2007). (Pubitemid 47302656)
-
(2007)
Free Radical Biology and Medicine
, vol.43
, Issue.7
, pp. 995-1022
-
-
Wardman, P.1
-
20
-
-
79953329777
-
Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NFkappaB/IL-8 pathway that drives tumor angiogenesis
-
Vegran, F., Boidot, R., Michiels, C., Sonveaux, P. & Feron, O. Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NFkappaB/IL-8 pathway that drives tumor angiogenesis. Cancer Res 71, 2550-2560 (2011).
-
(2011)
Cancer Res
, vol.71
, pp. 2550-2560
-
-
Vegran, F.1
Boidot, R.2
Michiels, C.3
Sonveaux, P.4
Feron, O.5
-
21
-
-
80053154634
-
Proteins as binding targets of isothiocyanates in cancer prevention
-
Mi, L., Di Pasqua, A. J. & Chung, F. L. Proteins as binding targets of isothiocyanates in cancer prevention. Carcinogenesis 32, 1405-1413 (2011).
-
(2011)
Carcinogenesis
, vol.32
, pp. 1405-1413
-
-
Mi, L.1
Di Pasqua, A.J.2
Chung, F.L.3
-
22
-
-
58149157900
-
The genomic analysis of lactic acidosis and acidosis response in human cancers
-
Chen, J. L. et al. The genomic analysis of lactic acidosis and acidosis response in human cancers. PLoS Genet 4, e1000293 (2008).
-
(2008)
PLoS Genet
, vol.4
-
-
Chen, J.L.1
-
23
-
-
78049415422
-
Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through mondoa
-
Chen, J. L. et al. Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA. PLoS Genet 6, e1001093 (2010).
-
(2010)
PLoS Genet
, vol.6
-
-
Chen, J.L.1
-
24
-
-
84877597763
-
Tumor environmental factors glucose deprivation and lactic acidosis induce mitotic chromosomal instability-an implication in aneuploid human tumors
-
Dai, C., Sun, F., Zhu, C. & Hu, X. Tumor environmental factors glucose deprivation and lactic acidosis induce mitotic chromosomal instability-an implication in aneuploid human tumors. PLoS One 8, e63054 (2013).
-
(2013)
PLoS One
, vol.8
-
-
Dai, C.1
Sun, F.2
Zhu, C.3
Hu, X.4
-
25
-
-
65549170684
-
The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion
-
Silva, A. S., Yunes, J. A., Gillies, R. J. & Gatenby, R. A. The potential role of systemic buffers in reducing intratumoral extracellular pH and acid-mediated invasion. Cancer Res 69, 2677-2684 (2009).
-
(2009)
Cancer Res
, vol.69
, pp. 2677-2684
-
-
Silva, A.S.1
Yunes, J.A.2
Gillies, R.J.3
Gatenby, R.A.4
-
26
-
-
67650071137
-
Targeting cancer cells by ROSmediated mechanisms: A radical therapeutic approach?
-
Trachootham, D., Alexandre, J. & Huang, P. Targeting cancer cells by ROSmediated mechanisms: a radical therapeutic approach? Nat Rev Drug Discov 8, 579-591 (2009).
-
(2009)
Nat Rev Drug Discov
, vol.8
, pp. 579-591
-
-
Trachootham, D.1
Alexandre, J.2
Huang, P.3
-
27
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza, G. L. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 3, 721-732 (2003). (Pubitemid 37328811)
-
(2003)
Nature Reviews Cancer
, vol.3
, Issue.10
, pp. 721-732
-
-
Semenza, G.L.1
-
28
-
-
34250788809
-
Akt/pkb signaling: Navigating downstream
-
DOI 10.1016/j.cell.2007.06.009, PII S0092867407007751
-
Manning, B. D. & Cantley, L. C. AKT/PKB signaling: navigating downstream. Cell 129, 1261-1274 (2007). (Pubitemid 46962095)
-
(2007)
Cell
, vol.129
, Issue.7
, pp. 1261-1274
-
-
Manning, B.D.1
Cantley, L.C.2
-
30
-
-
0005763468
-
Use of the pH-sensitive dye BCECF to study pH regulation in cultured human kidney proximal tubule cells
-
Bergman, J. A., McAteer, J. A., Evan, A. P. & Soleimani, M. Use of the pH-sensitive dye BCECF to study pH regulation in cultured human kidney proximal tubule cells. Journal of tissue culture methods 13, 205-209 (1991).
-
(1991)
Journal of Tissue Culture Methods
, vol.13
, pp. 205-209
-
-
Bergman, J.A.1
McAteer, J.A.2
Evan, A.P.3
Soleimani, M.4
-
31
-
-
0036449401
-
Monitoring intracellular pH changes in response to osmotic stress and membrane transport activity using 5- chloromethylfluorescein
-
Salvi, A., Quillan, J. M. & Sadee, W. Monitoring intracellular pH changes in response to osmotic stress and membrane transport activity using 5- chloromethylfluorescein. AAPS PharmSci 4, E21 (2002).
-
(2002)
AAPS PharmSci
, vol.4
-
-
Salvi, A.1
Quillan, J.M.2
Sadee, W.3
-
32
-
-
0018764575
-
Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ
-
DOI 10.1021/bi00578a012
-
Thomas, J. A., Buchsbaum, R. N., Zimniak, A. & Racker, E. Intracellular pH measurements in Ehrlich ascites tumor cells utilizing spectroscopic probes generated in situ. Biochemistry (Mosc) 18, 2210-2218 (1979). (Pubitemid 9191034)
-
(1979)
Biochemistry
, vol.18
, Issue.11
, pp. 2210-2218
-
-
Thomas, J.A.1
Buchsbaum, R.N.2
Zimniak, A.3
Racker, E.4
-
33
-
-
0005162157
-
Alterations in glucose metabolism in chick-embryo cells transformed by rous sarcoma virus: Intracellular levels of glycolytic intermediates
-
Singh, V. N., Singh, M., August, J. T. & Horecker, B. L. Alterations in glucose metabolism in chick-embryo cells transformed by Rous sarcoma virus: intracellular levels of glycolytic intermediates. Proc Natl Acad Sci U S A 71, 4129-4132 (1974).
-
(1974)
Proc Natl Acad Sci U S A
, vol.71
, pp. 4129-4132
-
-
Singh, V.N.1
Singh, M.2
August, J.T.3
Horecker, B.L.4
-
34
-
-
84900457806
-
-
3rd edn, (Verlag Chemie)
-
Bergmeyer, H. U., Bergmeyer, J. & Grassl, M. Metabolites 1, Carbohydrates. 3rd edn, Vol. 6 (Verlag Chemie, 1984).
-
(1984)
Metabolites 1, Carbohydrates
, vol.6
-
-
Bergmeyer, H.U.1
Bergmeyer, J.2
Grassl, M.3
-
36
-
-
0021001207
-
Thermodynamic studies of the activation of rabbit muscle lactate dehydrogenase by phosphate
-
Ward, L. D. & Winzor, D. J. Thermodynamic studies of the activation of rabbit muscle lactate dehydrogenase by phosphate. Biochem J 215, 685-691 (1983).
-
(1983)
Biochem J
, vol.215
, pp. 685-691
-
-
Ward, L.D.1
Winzor, D.J.2
-
37
-
-
33745530619
-
Biochemical thermodynamics: Applications of mathematica
-
Alberty, R. A. Biochemical thermodynamics: applications of Mathematica. Methods Biochem Anal 48, 1-458 (2006).
-
(2006)
Methods Biochem Anal
, vol.48
, pp. 1-458
-
-
Alberty, R.A.1
-
38
-
-
41549134728
-
Biochemical thermodynamics under near physiological conditions
-
DOI 10.1002/bmb.20157
-
Mendez, E. Biochemical thermodynamics under near physiological conditions. Biochem Mol Biol Educ 36, 116-119 (2008). (Pubitemid 351464792)
-
(2008)
Biochemistry and Molecular Biology Education
, vol.36
, Issue.2
, pp. 116-119
-
-
Mendez, E.1
-
40
-
-
49549145537
-
Thermochemistry of the reaction catalyzed by lactate dehydrogenase
-
Donnovan, L. K., Barclay, K. O. & Jespersen, N. Thermochemistry of the reaction catalyzed by lactate dehydrogenase. Thermochim Acta 11, 151-156 (1975).
-
(1975)
Thermochim Acta
, vol.11
, pp. 151-156
-
-
Donnovan, L.K.1
Barclay, K.O.2
Jespersen, N.3
-
41
-
-
25544476600
-
Thermodynamics of redox reactions involving nicotinamide adenine dinucleotide
-
Rekharsky, M. V., Egorov, A. M., Gal'chenko, G. L. & Berezin, I. V. Thermodynamics of redox reactions involving nicotinamide adenine dinucleotide. Thermochim Acta 46, 89-101 (1981).
-
(1981)
Thermochim Acta
, vol.46
, pp. 89-101
-
-
Rekharsky, M.V.1
Egorov, A.M.2
Gal'chenko, G.L.3
Berezin, I.V.4
-
42
-
-
9844268087
-
Studies of the phosphoglucose isomerase of schistosoma mansoni
-
Bueding, E. & Mackinnon, J. A. Studies of the phosphoglucose isomerase of Schistosoma mansoni. J Biol Chem 215, 507-513 (1955).
-
(1955)
J Biol Chem
, vol.215
, pp. 507-513
-
-
Bueding, E.1
MacKinnon, J.A.2
-
43
-
-
33748456179
-
Purification and some properties of phosphorylglyceric acid mutase from rabbit skeletal muscle
-
Cowgill, R. W. & Pizer, L. I. Purification and some properties of phosphorylglyceric acid mutase from rabbit skeletal muscle. J Biol Chem 223, 885-895 (1956).
-
(1956)
J Biol Chem
, vol.223
, pp. 885-895
-
-
Cowgill, R.W.1
Pizer, L.I.2
-
44
-
-
51049089100
-
Phosphorylation of bad at thr-201 by JNK1 promotes glycolysis through activation of phosphofructokinase-1
-
Deng, H. et al. Phosphorylation of Bad at Thr-201 by JNK1 promotes glycolysis through activation of phosphofructokinase-1. J Biol Chem 283, 20754-20760 (2008).
-
(2008)
J Biol Chem
, vol.283
, pp. 20754-20760
-
-
Deng, H.1
-
45
-
-
0013770850
-
The isolation and specific activity of rabbit-muscle glyceraldehyde phosphate dehydrogenase
-
Ferdinand, W. The isolation and specific activity of rabbit-muscle glyceraldehyde phosphate dehydrogenase. Biochem J 92, 578-585 (1964).
-
(1964)
Biochem J
, vol.92
, pp. 578-585
-
-
Ferdinand, W.1
-
46
-
-
0014690721
-
Subunit structure and chemical properties of rabbit liver aldolase
-
Gracy, R. W., Lacko, A. G. & Horecker, B. L. Subunit structure and chemical properties of rabbit liver aldolase. J Biol Chem 244, 3913-3919 (1969).
-
(1969)
J Biol Chem
, vol.244
, pp. 3913-3919
-
-
Gracy, R.W.1
Lacko, A.G.2
Horecker, B.L.3
-
47
-
-
0032524663
-
2 isozyme involves a cysteine residue in the intersubunit contact
-
DOI 10.1074/jbc.273.20.12227
-
Ikeda, Y. & Noguchi, T. Allosteric regulation of pyruvate kinase M2 isozyme involves a cysteine residue in the intersubunit contact. J Biol Chem 273, 12227-12233 (1998). (Pubitemid 28240587)
-
(1998)
Journal of Biological Chemistry
, vol.273
, Issue.20
, pp. 12227-12233
-
-
Ikeda, Y.1
Noguchi, T.2
-
48
-
-
0024430062
-
Enolase exists in the fluid phase of cytoplasm in 3T3 cells
-
Pagliaro, L., Kerr, K. & Taylor, D. L. Enolase exists in the fluid phase of cytoplasm in 3T3 cells. J Cell Sci 94 (Pt 2), 333-342 (1989). (Pubitemid 19272967)
-
(1989)
Journal of Cell Science
, vol.94
, Issue.2
, pp. 333-342
-
-
Pagliaro, L.1
Kerr, K.2
Taylor, D.L.3
-
49
-
-
0015394088
-
PH-dependence of the triose phosphate isomerase reaction
-
Plaut, B. & Knowles, J. R. pH-dependence of the triose phosphate isomerase reaction. Biochem J 129, 311-320 (1972).
-
(1972)
Biochem J
, vol.129
, pp. 311-320
-
-
Plaut, B.1
Knowles, J.R.2
-
50
-
-
0014544932
-
Crystalline 3-phosphoglycerate kinase from skeletal muscle
-
Scopes, R. K. Crystalline 3-phosphoglycerate kinase from skeletal muscle. Biochem J 113, 551-554 (1969).
-
(1969)
Biochem J
, vol.113
, pp. 551-554
-
-
Scopes, R.K.1
-
51
-
-
12044255619
-
Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing
-
Sekine, N. et al. Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing. J Biol Chem 269, 4895-4902 (1994).
-
(1994)
J Biol Chem
, vol.269
, pp. 4895-4902
-
-
Sekine, N.1
-
52
-
-
0014409401
-
Brain hexokinase. A proposed relation between soluble-particulate distribution and activity in vivo
-
Wilson, J. E. Brain hexokinase. A proposed relation between soluble-particulate distribution and activity in vivo. J Biol Chem 243, 3640-3647 (1968).
-
(1968)
J Biol Chem
, vol.243
, pp. 3640-3647
-
-
Wilson, J.E.1
-
53
-
-
34250748014
-
Shikonin circumvents cancer drug resistance by induction of a necroptotic death
-
DOI 10.1158/1535-7163.MCT-06-0511
-
Han, W. et al. Shikonin circumvents cancer drug resistance by induction of a necroptotic death. Mol Cancer Ther 6, 1641-1649 (2007). (Pubitemid 46954031)
-
(2007)
Molecular Cancer Therapeutics
, vol.6
, Issue.5
, pp. 1641-1649
-
-
Han, W.1
Li, L.2
Qiu, S.3
Lu, Q.4
Pan, Q.5
Gu, Y.6
Luo, J.7
Hu, X.8
-
54
-
-
0034469418
-
Nontransgenic models of breast cancer
-
DOI 10.1186/bcr77
-
Heppner, G. H., Miller, F. R. & Shekhar, P. M. Nontransgenic models of breast cancer. Breast Cancer Res 2, 331-334 (2000). (Pubitemid 32223615)
-
(2000)
Breast Cancer Research
, vol.2
, Issue.5
, pp. 331-334
-
-
Heppner, G.H.1
Miller, F.R.2
Shekhar, P.V.M.3
|