Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation

Immunity

Volumn 40, Issue 5, 2014, Pages 692-705

  Nakaya, Mako ^a   Xiao, Yichuan ^a   Zhou, Xiaofei ^a   Chang, Jae Hoon ^a,c   Chang, Mikyoung ^a   Cheng, Xuhong ^a   Blonska, Marzenna ^a   Lin, Xin ^a,b   Sun, Shao Cong ^a,b  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c Yeungnam University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID TRANSPORTER; AMINO ACID TRANSPORTER ASCT2; CASPASE; GLUTAMINE; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PARACASPASE MALT1; PROTEIN BCL 10; SCAFFOLD PROTEIN; SCAFFOLD PROTEIN CARMA1; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOIMMUNITY; CONTROLLED STUDY; ENZYME ACTIVATION; IMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH17 CELL;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADOPTIVE TRANSFER; AMINO ACID TRANSPORT SYSTEM ASC; ANIMALS; ANTIGENS, CD28; BIOLOGICAL TRANSPORT; CARD SIGNALING ADAPTOR PROTEINS; CASPASES; CELL DIFFERENTIATION; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENZYME ACTIVATION; GLUTAMINE; HUMANS; INFLAMMATION; INTERLEUKIN-2; JURKAT CELLS; LEUCINE; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MULTIPROTEIN COMPLEXES; NEOPLASM PROTEINS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; TH1 CELLS; TOR SERINE-THREONINE KINASES;

EID: 84900440370     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2014.04.007     Document Type: Article

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