Mitochondrial fission induces glycolytic reprogramming in cancer-associated myofibroblasts, driving stromal lactate production, and early tumor growth

Oncotarget

Volumn 3, Issue 8, 2012, Pages 798-810

  Guido, Carmela ^a,b,c   Whitaker Menezes, Diana ^a,b   Lin, Zhao ^a,b   Pestell, Richard G ^a,b   Howell, Anthony ^d   Zimmers, Teresa A ^a,b   Casimiro, Mathew C ^a,b   Aquila, Saveria ^c   Ando', Sebastiano ^c   Martinez Outschoorn, Ubaldo E ^a,b   Sotgia, Federica ^a,b,d   Lisanti, Michael P ^a,b,d  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c UNIVERSITY OF CALABRIA   (Italy)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Aerobic glycolysis; Autophagy; Cancer associated fibroblast; Cancer metabolism; Mitochondrial fission; Mitophagy; Myofibroblast; Onco catabolite; Oxidative stress; Tumor initiation; Tumor stroma

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALPONIN; CARRIER PROTEIN; CATHEPSIN B; CELL PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTIC ACID; MITOCHONDRIAL FISSION FACTOR; MITOCHONDRIAL PROTEIN; PROTEIN BNIP3; PROTEIN BNIP3L; PROTEIN LC3 I; PROTEIN LC3 II; REACTIVE OXYGEN METABOLITE; SMOOTH MUSCLE ACTIN; UNCLASSIFIED DRUG;

AMINO ACID SYNTHESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CARCINOGENESIS; CATABOLISM; CELL DIFFERENTIATION; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; EARLY CANCER; ENZYME ACTIVATION; GLYCOLYSIS; HUMAN; HUMAN CELL; METABOLIC REPROGRAMMING; METABOLISM; MITOCHONDRIAL ENERGY TRANSFER; MITOPHAGY; MOLECULAR PATHOLOGY; MOUSE; MYOFIBROBLAST; MYOFIBROBLAST DIFFERENTIATION; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; PROTEIN FUNCTION; TUMOR GROWTH; TUMOR PROMOTION; TUMOR VASCULARIZATION; UPREGULATION;

EID: 84868625980     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.574     Document Type: Article

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