Inhibition of the Glycolytic Activator PFKFB3 in Endothelium Induces Tumor Vessel Normalization, Impairs Metastasis, and Improves Chemotherapy

Cancer Cell

Volumn 30, Issue 6, 2016, Pages 968-985

  Cantelmo, Anna Rita ^a,b   Conradi, Lena Christin ^a,b   Brajic, Aleksandra ^a,b   Goveia, Jermaine ^a,b   Kalucka, Joanna ^a,b   Pircher, Andreas ^a,b   Chaturvedi, Pallavi ^c   Hol, Johanna ^d   Thienpont, Bernard ^b,e   Teuwen, Laure Anne ^a,b   Schoors, Sandra ^a,b   Boeckx, Bram ^b,e   Vriens, Joris ^f   Kuchnio, Anna ^a,b   Veys, Koen ^a,b   Cruys, Bert ^a,b   Finotto, Lise ^a,b   Treps, Lucas ^a,b   Stav Noraas, Tor Espen ^d   Bifari, Francesco ^a,b   Stapor, Peter ^a,b   Decimo, Ilaria ^a,b   Kampen, Kim ^a,b   De Bock, Katrien ^a,b   Haraldsen, Guttorm ^d   Schoonjans, Luc ^a,b   Rabelink, Ton ^g   Eelen, Guy ^a,b   Ghesquière, Bart ^a,b   Rehman, Jalees ^c   Lambrechts, Diether ^b,e   Malik, Asrar B ^c   Dewerchin, Mieke ^a,b   Carmeliet, Peter ^a,b   more..

^a UNIVERSITY OF LEUVEN   (Belgium)

^b DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

^c UNIVERSITY OF ILLINOIS   (United States)

^d OSLO UNIVERSITY HOSPITAL   (Norway)

^e UNIVERSITY OF LEUVEN   (Belgium)

^f LABORATORY OF MOLECULAR AND CELLULAR SIGNALING   (Belgium)

^g LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

angiogenesis; chemotherapy; glycolysis; metastasis; tumor endothelial cell metabolism; tumor vessel normalization

Indexed keywords

3 [(3 PYRIDINYL) 1 (4 PYRIDINYL)] 2 PROPEN 1 ONE; ANGIOGENESIS INHIBITOR; CISPLATIN; ENZYME INHIBITOR; GLYCOLYTIC ENZYME; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NERVE CELL ADHESION MOLECULE; PFKFB3 ENZYME; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CADHERIN; 6 PHOSPHOFRUCTO 2 KINASE; CADHERIN; CDH2 PROTEIN, MOUSE; PFKFB3 PROTEIN, HUMAN; TAMOXIFEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIANGIOGENIC ACTIVITY; ANTIANGIOGENIC THERAPY; ARTICLE; CANCER CHEMOTHERAPY; CONTROLLED STUDY; ENDOCYTOSIS; ENDOTHELIUM CELL; ENZYME INHIBITION; GLYCOLYSIS; HUMAN; HUMAN CELL; LIVER METASTASIS; LOW DRUG DOSE; LUNG METASTASIS; MELANOMA; METASTASIS; MOUSE; NONHUMAN; NUCLEOTIDE METABOLISM; PANCREAS TUMOR; PERICYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SINGLE DRUG DOSE; TUMOR GROWTH; TUMOR INVASION; UPREGULATION; ANIMAL; ANTAGONISTS AND INHIBITORS; CANCER TRANSPLANTATION; CELL MOTION; DRUG EFFECTS; DRUG POTENTIATION; DRUG THERAPY; EPITHELIUM CELL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NEOPLASMS; PATHOLOGY; TUMOR CELL LINE; UMBILICAL VEIN ENDOTHELIAL CELL; VASCULARIZATION;

ANIMALS; CADHERINS; CELL LINE, TUMOR; CELL MOVEMENT; CISPLATIN; DRUG SYNERGISM; DRUG THERAPY; EPITHELIAL CELLS; GENE EXPRESSION REGULATION, NEOPLASTIC; GLYCOLYSIS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; MICE; NEOPLASM INVASIVENESS; NEOPLASM METASTASIS; NEOPLASM TRANSPLANTATION; NEOPLASMS; PHOSPHOFRUCTOKINASE-2; TAMOXIFEN;

EID: 85004144063     PISSN: 15356108     EISSN: 18783686     Source Type: Journal    
DOI: 10.1016/j.ccell.2016.10.006     Document Type: Article

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