Curcumin inhibits aerobic glycolysis in hepatic stellate cells associated with activation of adenosine monophosphate-activated protein kinase

IUBMB Life

Volumn , Issue , 2016, Pages 589-596

  Lian, Naqi ^a   Jin, Huanhuan ^a   Zhang, Feng ^a   Wu, Li ^a   Shao, Jiangjuan ^a   Lu, Yin ^a   Zheng, Shizhong ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

adenosine monophosphate activated protein kinase; aerobic glycolysis; curcumin; hepatic stellate cell; liver fibrosis

Indexed keywords

6 PHOSPHOFRUCTO 2 KINASE; ADENYLATE KINASE; ALPHA SMOOTH MUSCLE ACTIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; CURCUMIN; DEOXYGLUCOSE; DORSOMORPHIN; GLUCOSE 6 PHOSPHATE; GLUCOSE TRANSPORTER 4; HEXOKINASE; LACTIC ACID; MESSENGER RNA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROCOLLAGEN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DENSITOMETRY; DOWN REGULATION; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME PHOSPHORYLATION; GLYCOLYSIS; NONHUMAN; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STELLATE CELL; WESTERN BLOTTING;

EID: 84975215640     PISSN: 15216543     EISSN: 15216551     Source Type: Journal    
DOI: 10.1002/iub.1518     Document Type: Article

References (30)

1. Lee, Y. A., Wallace, M. C., and Friedman, S. L. (2015) Pathobiology of liver fibrosis: a translational success story. Gut 64, 830–841.
2. Yin, C., Evason, K. J., Asahina, K., and Stainier, D. Y. (2013) Hepatic stellate cells in liver development, regeneration, and cancer. J. Clin. Invest. 123, 1902–1910.
3. Chen, Y., Choi, S. S., Michelotti, G. A., Chan, I. S., Swiderska-Syn, M., et al. (2012) Hedgehog controls hepatic stellate cell fate by regulating metabolism. Gastroenterology 143, 1319–1329. e1311-1311.
4. Lunt, S. Y. and Vander Heiden, M. G. (2011) Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu. Rev. Cell Dev. Biol. 27, 441–464.
5. Karagounis, L. G. and Hawley, J. A. (2009) The 5' adenosine monophosphate-activated protein kinase: regulating the ebb and flow of cellular energetics. Int. J. Biochem. Cell Biol. 41, 2360–2363.
6. Caligiuri, A., Bertolani, C., Guerra, C. T., Aleffi, S., Galastri, S., et al. (2008) Adenosine monophosphate-activated protein kinase modulates the activated phenotype of hepatic stellate cells. Hepatology 47, 668–676.
7. Adachi, M. and Brenner, D. A. (2008) High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphate-activated protein kinase. Hepatology 47, 677–685.
8. Vera-Ramirez, L., Perez-Lopez, P., Varela-Lopez, A., Ramirez-Tortosa, M., Battino, M., et al. (2013) Curcumin and liver disease. Biofactors 39, 88–100.
9. Zheng, S. and Chen, A. (2007) Disruption of transforming growth factor-beta signaling by curcumin induces gene expression of peroxisome proliferator-activated receptor-gamma in rat hepatic stellate cells. Am. J. Physiol. Gastrointest. Liver Physiol. 292, G113–G123.
10. Zhou, Y., Zheng, S., Lin, J., Zhang, Q. J., and Chen, A. (2007) The interruption of the PDGF and EGF signaling pathways by curcumin stimulates gene expression of PPARgamma in rat activated hepatic stellate cell in vitro. Lab. Invest. 87, 488–498.
11. Zhang, Z., Guo, Y., Zhang, S., Zhang, Y., Wang, Y., et al. (2013) Curcumin modulates cannabinoid receptors in liver fibrosis in vivo and inhibits extracellular matrix expression in hepatic stellate cells by suppressing cannabinoid receptor type-1 in vitro. Eur. J. Pharmacol. 721, 133–140.
12. Zhang, F., Zhang, Z., Chen, L., Kong, D., Zhang, X., et al. (2014) Curcumin attenuates angiogenesis in liver fibrosis and inhibits angiogenic properties of hepatic stellate cells. J. Cell. Mol. Med. 18, 1392–1406.
13. Zhang, F., Kong, D. S., Zhang, Z. L., Lei, N., Zhu, X. J., et al. (2013) Tetramethylpyrazine induces G0/G1 cell cycle arrest and stimulates mitochondrial-mediated and caspase-dependent apoptosis through modulating ERK/p53 signaling in hepatic stellate cells in vitro. Apoptosis 18, 135–149.
14. Zhang, F., Ni, C., Kong, D., Zhang, X., Zhu, X., et al. (2012) Ligustrazine attenuates oxidative stress-induced activation of hepatic stellate cells by interrupting platelet-derived growth factor-beta receptor-mediated ERK and p38 pathways. Toxicol. Appl. Pharmacol. 265, 51–60.
15. Schmittgen, T. D., Zakrajsek, B. A., Mills, A. G., Gorn, V., Singer, M. J., et al. (2000) Quantitative reverse transcription-polymerase chain reaction to study mRNA decay: comparison of endpoint and real-time methods. Anal. Biochem. 285, 194–204.
16. Ciavardelli, D., Rossi, C., Barcaroli, D., Volpe, S., Consalvo, A., et al. (2014) Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment. Cell Death Dis. 5, e1336.
17. Han, X., Sheng, X., Jones, H. M., Jackson, A. L., Kilgore, J., et al. (2015) Evaluation of the anti-tumor effects of lactate dehydrogenase inhibitor galloflavin in endometrial cancer cells. J. Hematol. Oncol. 8, 2.
18. She, H., Xiong, S., Hazra, S., and Tsukamoto, H. (2005) Adipogenic transcriptional regulation of hepatic stellate cells. J. Biol. Chem. 280, 4959–4967.
19. Pfeiffer, T., Schuster, S., and Bonhoeffer, S. (2001) Cooperation and competition in the evolution of ATP-producing pathways. Science 292, 504–507.
20. Nerlov, C. (2007) The C/EBP family of transcription factors: a paradigm for interaction between gene expression and proliferation control. Trends Cell Biol. 17, 318–324.
21. Zhang, F., Kong, D., Lu, Y., and Zheng, S. (2013) Peroxisome proliferator-activated receptor-gamma as a therapeutic target for hepatic fibrosis: from bench to bedside. Cell. Mol. Life Sci. 70, 259–276.
22. Tang, Y. (2015) Curcumin targets multiple pathways to halt hepatic stellate cell activation: updated mechanisms in vitro and in vivo. Dig. Dis. Sci. 60, 1554–1564.
23. Zheng, S. and Chen, A. (2006) Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor. Am. J. Physiol. Gastrointest. Liver Physiol. 290, G883–G893.
24. Tang, Y. and Chen, A. (2010) Curcumin protects hepatic stellate cells against leptin-induced activation in vitro by accumulating intracellular lipids. Endocrinology 151, 4168–4177.
25. Wang, K., Fan, H., Chen, Q., Ma, G., Zhu, M., et al. (2015) Curcumin inhibits aerobic glycolysis and induces mitochondrial-mediated apoptosis through hexokinase II in human colorectal cancer cells in vitro. Anticancer Drugs 26, 15–24.
26. Vaughan, R. A., Garcia-Smith, R., Dorsey, J., Griffith, J. K., Bisoffi, M., et al. (2013) Tumor necrosis factor alpha induces Warburg-like metabolism and is reversed by anti-inflammatory curcumin in breast epithelial cells. Int. J. Cancer 133, 2504–2510.
27. Liu, J., Zheng, L., Wu, N., Ma, L., Zhong, J., et al. (2014) Oleanolic acid induces metabolic adaptation in cancer cells by activating the AMP-activated protein kinase pathway. J. Agric. Food Chem. 62, 5528–5537.
28. Zhai, X., Qiao, H., Guan, W., Li, Z., Cheng, Y., et al. (2015) Curcumin regulates peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression by AMPK pathway in hepatic stellate cells in vitro. Eur. J. Pharmacol. 746, 56–62.
29. Xiao, K., Jiang, J., Guan, C., Dong, C., Wang, G., et al. (2013) Curcumin induces autophagy via activating the AMPK signaling pathway in lung adenocarcinoma cells. J. Pharmacol. Sci. 123, 102–109.
30. Li, Y., Li, J., Li, S., Wang, X., Liu, B., et al. (2015) Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK. Toxicol. Appl. Pharmacol. 286, 53–63.