-
1
-
-
0001394564
-
Observations on the Proliferation of Human Leucocytes Cultured with Phytohaemagglutinin
-
Cooper EH, Barkhan P, Hale AJ (1963) Observations on the Proliferation of Human Leucocytes Cultured with Phytohaemagglutinin. Brit J Haemat 9: 101-111.
-
(1963)
Brit J Haemat
, vol.9
, pp. 101-111
-
-
Cooper, E.H.1
Barkhan, P.2
Hale, A.J.3
-
2
-
-
0014356282
-
Early effects of phytohaemagglutinin on glucose metabolism of normal human lymphocytes
-
Hedeskov CJ (1968) Early effects of phytohaemagglutinin on glucose metabolism of normal human lymphocytes. Biochem J 110: 373-380.
-
(1968)
Biochem J
, vol.110
, pp. 373-380
-
-
Hedeskov, C.J.1
-
3
-
-
0014967402
-
Changes in the carbohydrate metabolism of mitogenically stimulated human peripheral lymphocytes. I. Stimulation by phytohaemagglutinin
-
Roos D, Loos JA (1970) Changes in the carbohydrate metabolism of mitogenically stimulated human peripheral lymphocytes. I. Stimulation by phytohaemagglutinin. Biochim Biophys Acta 222: 565-582.
-
(1970)
Biochim Biophys Acta
, vol.222
, pp. 565-582
-
-
Roos, D.1
Loos, J.A.2
-
4
-
-
0016177487
-
Alterations in hexose monophosphate shunt during lymphoblastic transformation
-
Sagone AL, Jr., LoBuglio AF, Balcerzak SP (1974) Alterations in hexose monophosphate shunt during lymphoblastic transformation. Cell Immunol 14: 443-452.
-
(1974)
Cell Immunol
, vol.14
, pp. 443-452
-
-
Sagone Jr., A.L.1
Lobuglio, A.F.2
Balcerzak, S.P.3
-
5
-
-
0017197310
-
Phytohaemagglutinin stimulation of rat thymus lymphocytes glycolysis
-
Culvenor JG, Weidemann MJ (1976) Phytohaemagglutinin stimulation of rat thymus lymphocytes glycolysis. Biochim Biophys Acta 437: 354-363.
-
(1976)
Biochim Biophys Acta
, vol.437
, pp. 354-363
-
-
Culvenor, J.G.1
Weidemann, M.J.2
-
6
-
-
0001221508
-
On respiratory impairment in cancer cells
-
Warburg O (1956) On respiratory impairment in cancer cells. Science 124: 269-270.
-
(1956)
Science
, vol.124
, pp. 269-270
-
-
Warburg, O.1
-
7
-
-
37449024702
-
The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
-
DeBerardinis RJ, Lum JJ, Hatzivassiliou G, Thompson CB (2008) The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab 7: 11-20.
-
(2008)
Cell Metab
, vol.7
, pp. 11-20
-
-
Deberardinis, R.J.1
Lum, J.J.2
Hatzivassiliou, G.3
Thompson, C.B.4
-
8
-
-
52649107626
-
Cancer cell metabolism: Warburg and beyond
-
Hsu PP, Sabatini DM (2008) Cancer cell metabolism: Warburg and beyond. Cell 134: 703-707.
-
(2008)
Cell
, vol.134
, pp. 703-707
-
-
Hsu, P.P.1
Sabatini, D.M.2
-
9
-
-
66249108601
-
Understanding the Warburg effect: The metabolic requirements of cell proliferation
-
Vander Heiden MG, Cantley LC, Thompson CB (2009) Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324: 1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
van der Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
10
-
-
0033635249
-
In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability
-
Rathmell JC, Vander Heiden MG, Harris MH, Frauwirth KA, Thompson CB (2000) In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Mol Cell 6: 683-692.
-
(2000)
Mol Cell
, vol.6
, pp. 683-692
-
-
Rathmell, J.C.1
van der Heiden, M.G.2
Harris, M.H.3
Frauwirth, K.A.4
Thompson, C.B.5
-
11
-
-
0035892899
-
IL-7 enhances the survival and maintains the size of naive T cells
-
Rathmell JC, Farkash EA, Gao W, Thompson CB (2001) IL-7 enhances the survival and maintains the size of naive T cells. J Immunol 167: 6869-6876.
-
(2001)
J Immunol
, vol.167
, pp. 6869-6876
-
-
Rathmell, J.C.1
Farkash, E.A.2
Gao, W.3
Thompson, C.B.4
-
12
-
-
0036069699
-
The CD28 Signaling Pathway Regulates Glucose Metabolism
-
Frauwirth KA, Riley JL, Harris MH, Parry RV, Rathmell JC, et al. (2002) The CD28 Signaling Pathway Regulates Glucose Metabolism. Immunity 16: 769-777.
-
(2002)
Immunity
, vol.16
, pp. 769-777
-
-
Frauwirth, K.A.1
Riley, J.L.2
Harris, M.H.3
Parry, R.V.4
Rathmell, J.C.5
-
13
-
-
44449165597
-
Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways
-
Jacobs SR, Herman CE, MacIver NJ, Wofford JA, Wieman HL, et al. (2008) Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways. Journal of Immunology 180: 4476-4486.
-
(2008)
Journal of Immunology
, vol.180
, pp. 4476-4486
-
-
Jacobs, S.R.1
Herman, C.E.2
Maciver, N.J.3
Wofford, J.A.4
Wieman, H.L.5
-
14
-
-
27144496045
-
CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms
-
Parry RV, Chemnitz JM, Frauwirth KA, Lanfranco AR, Braunstein I, et al. (2005) CTLA-4 and PD-1 receptors inhibit T-cell activation by distinct mechanisms. Mol Cell Biol 25: 9543-9553.
-
(2005)
Mol Cell Biol
, vol.25
, pp. 9543-9553
-
-
Parry, R.V.1
Chemnitz, J.M.2
Frauwirth, K.A.3
Lanfranco, A.R.4
Braunstein, I.5
-
15
-
-
68649090226
-
Regulation of mitochondrial dehydrogenases by calcium ions
-
Denton RM (2009) Regulation of mitochondrial dehydrogenases by calcium ions. Biochim Biophys Acta 1787: 1309-1316.
-
(2009)
Biochim Biophys Acta
, vol.1787
, pp. 1309-1316
-
-
Denton, R.M.1
-
16
-
-
34848913375
-
T cell activation requires mitochondrial translocation to the immunological synapse
-
Quintana A, Schwindling C, Wenning AS, Becherer U, Rettig J, et al. (2007) T cell activation requires mitochondrial translocation to the immunological synapse. Proc Natl Acad Sci U S A 104: 14418-14423.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 14418-14423
-
-
Quintana, A.1
Schwindling, C.2
Wenning, A.S.3
Becherer, U.4
Rettig, J.5
-
17
-
-
0020617998
-
Glutamine metabolism in lymphocytes of the rat
-
Ardawi MS, Newsholme EA (1983) Glutamine metabolism in lymphocytes of the rat. Biochem J 212: 835-842.
-
(1983)
Biochem J
, vol.212
, pp. 835-842
-
-
Ardawi, M.S.1
Newsholme, E.A.2
-
18
-
-
0021148514
-
Glucose and glutamine metabolism in rat thymocytes
-
Brand K, Williams JF, Weidemann MJ (1984) Glucose and glutamine metabolism in rat thymocytes. Biochem J 221: 471-475.
-
(1984)
Biochem J
, vol.221
, pp. 471-475
-
-
Brand, K.1
Williams, J.F.2
Weidemann, M.J.3
-
19
-
-
0023870346
-
Glutamine and glucose metabolism in human peripheral lymphocytes
-
Ardawi MS (1988) Glutamine and glucose metabolism in human peripheral lymphocytes. Metabolism 37: 99-103.
-
(1988)
Metabolism
, vol.37
, pp. 99-103
-
-
Ardawi, M.S.1
-
20
-
-
0024383391
-
Metabolism of glutamine in lymphocytes
-
Brand K, Fekl W, von Hintzenstern J, Langer K, Luppa P, et al. (1989) Metabolism of glutamine in lymphocytes. Metabolism 38: 29-33.
-
(1989)
Metabolism
, vol.38
, pp. 29-33
-
-
Brand, K.1
Fekl, W.2
von Hintzenstern, J.3
Langer, K.4
Luppa, P.5
-
21
-
-
0025312271
-
Comparison between transport and degradation of leucine and glutamine by peripheral human lymphocytes exposed to concanavalin A
-
Koch B, Schroder MT, Schafer G, Schauder P (1990) Comparison between transport and degradation of leucine and glutamine by peripheral human lymphocytes exposed to concanavalin A. J Cell Physiol 143: 94-99.
-
(1990)
J Cell Physiol
, vol.143
, pp. 94-99
-
-
Koch, B.1
Schroder, M.T.2
Schafer, G.3
Schauder, P.4
-
22
-
-
77955475969
-
Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK During T Lymphocyte Activation
-
Carr EL, Kelman A, Wu GS, Gopaul R, Senkevitch E, et al. (2010) Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK During T Lymphocyte Activation. J Immunol 185: 1037-1044.
-
(2010)
J Immunol
, vol.185
, pp. 1037-1044
-
-
Carr, E.L.1
Kelman, A.2
Wu, G.S.3
Gopaul, R.4
Senkevitch, E.5
-
23
-
-
0032759257
-
Regulation of mesangial cell hexokinase activity by PKC and the classic MAPK pathway
-
Robey RB, Ma J, Santos AV (1999) Regulation of mesangial cell hexokinase activity by PKC and the classic MAPK pathway. Am J Physiol 277: F742-749.
-
(1999)
Am J Physiol
, vol.277
-
-
Robey, R.B.1
Ma, J.2
Santos, A.V.3
-
24
-
-
51049089100
-
Phosphorylation of Bad at Thr-201 by JNK1 promotes glycolysis through activation of phosphofructoki-nase-1
-
Deng H, Yu F, Chen J, Zhao Y, Xiang J, et al. (2008) Phosphorylation of Bad at Thr-201 by JNK1 promotes glycolysis through activation of phosphofructoki-nase-1. J Biol Chem 283: 20754-20760.
-
(2008)
J Biol Chem
, vol.283
, pp. 20754-20760
-
-
Deng, H.1
Yu, F.2
Chen, J.3
Zhao, Y.4
Xiang, J.5
-
25
-
-
37349081929
-
C-Jun N-terminal kinase regulates mitochondrial bioenergetics by modulating pyruvate dehydrogenase activity in primary cortical neurons
-
Zhou Q, Lam PY, Han D, Cadenas E (2008) c-Jun N-terminal kinase regulates mitochondrial bioenergetics by modulating pyruvate dehydrogenase activity in primary cortical neurons. J Neurochem 104: 325-335.
-
(2008)
J Neurochem
, vol.104
, pp. 325-335
-
-
Zhou, Q.1
Lam, P.Y.2
Han, D.3
Cadenas, E.4
-
26
-
-
0015924743
-
Changes in the carbohydrate metabolism of mitogenically stimulated human peripheral lymphocytes. II. Relative importance of glycolysis and oxidative phosphorylation on phytohaemagglutinin stimulation
-
Roos D, Loos JA (1973) Changes in the carbohydrate metabolism of mitogenically stimulated human peripheral lymphocytes. II. Relative importance of glycolysis and oxidative phosphorylation on phytohaemagglutinin stimulation. Exp Cell Res 77: 127-135.
-
(1973)
Exp Cell Res
, vol.77
, pp. 127-135
-
-
Roos, D.1
Loos, J.A.2
-
28
-
-
33744462050
-
Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: Role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth
-
Doughty CA, Bleiman BF, Wagner DJ, Dufort FJ, Mataraza JM, et al. (2006) Antigen receptor-mediated changes in glucose metabolism in B lymphocytes: role of phosphatidylinositol 3-kinase signaling in the glycolytic control of growth. Blood 107: 4458-4465.
-
(2006)
Blood
, vol.107
, pp. 4458-4465
-
-
Doughty, C.A.1
Bleiman, B.F.2
Wagner, D.J.3
Dufort, F.J.4
Mataraza, J.M.5
-
29
-
-
0029908016
-
Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation
-
Kohn AD, Summers SA, Birnbaum MJ, Roth RA (1996) Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation. J Biol Chem 271: 31372-31378.
-
(1996)
J Biol Chem
, vol.271
, pp. 31372-31378
-
-
Kohn, A.D.1
Summers, S.A.2
Birnbaum, M.J.3
Roth, R.A.4
-
30
-
-
0030734345
-
Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells
-
Cong LN, Chen H, Li Y, Zhou L, McGibbon MA, et al. (1997) Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells. Mol Endocrinol 11: 1881-1890.
-
(1997)
Mol Endocrinol
, vol.11
, pp. 1881-1890
-
-
Cong, L.N.1
Chen, H.2
Li, Y.3
Zhou, L.4
McGibbon, M.A.5
-
31
-
-
0033575290
-
Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1
-
Barthel A, Okino ST, Liao J, Nakatani K, Li J, et al. (1999) Regulation of GLUT1 gene transcription by the serine/threonine kinase Akt1. J Biol Chem 274: 20281-20286.
-
(1999)
J Biol Chem
, vol.274
, pp. 20281-20286
-
-
Barthel, A.1
Okino, S.T.2
Liao, J.3
Nakatani, K.4
Li, J.5
-
32
-
-
0032570815
-
Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis
-
Ueki K, Yamamoto-Honda R, Kaburagi Y, Yamauchi T, Tobe K, et al. (1998) Potential role of protein kinase B in insulin-induced glucose transport, glycogen synthesis, and protein synthesis. J Biol Chem 273: 5315-5322.
-
(1998)
J Biol Chem
, vol.273
, pp. 5315-5322
-
-
Ueki, K.1
Yamamoto-Honda, R.2
Kaburagi, Y.3
Yamauchi, T.4
Tobe, K.5
-
33
-
-
0032730328
-
Opposite translational control of GLUT1 and GLUT4 glucose transporter mRNAs in response to insulin. Role of mammalian target of rapamycin, protein kinase b, and phosphatidylinositol 3-kinase in GLUT1 mRNA translation
-
Taha C, Liu Z, Jin J, Al-Hasani H, Sonenberg N, et al. (1999) Opposite translational control of GLUT1 and GLUT4 glucose transporter mRNAs in response to insulin. Role of mammalian target of rapamycin, protein kinase b, and phosphatidylinositol 3-kinase in GLUT1 mRNA translation. J Biol Chem 274: 33085-33091.
-
(1999)
J Biol Chem
, vol.274
, pp. 33085-33091
-
-
Taha, C.1
Liu, Z.2
Jin, J.3
Al-Hasani, H.4
Sonenberg, N.5
-
34
-
-
0033049422
-
Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts
-
Wang Q, Somwar R, Bilan PJ, Liu Z, Jin J, et al. (1999) Protein kinase B/Akt participates in GLUT4 translocation by insulin in L6 myoblasts. Mol Cell Biol 19: 4008-4018.
-
(1999)
Mol Cell Biol
, vol.19
, pp. 4008-4018
-
-
Wang, Q.1
Somwar, R.2
Bilan, P.J.3
Liu, Z.4
Jin, J.5
-
35
-
-
0030686560
-
Ligation of the T cell co-stimulatory receptor CD28 activates the serine-threonine protein kinase protein kinase B
-
Parry RV, Reif K, Smith G, Sansom DM, Hemmings BA, et al. (1997) Ligation of the T cell co-stimulatory receptor CD28 activates the serine-threonine protein kinase protein kinase B. Eur J Immunol 27: 2495-2501.
-
(1997)
Eur J Immunol
, vol.27
, pp. 2495-2501
-
-
Parry, R.V.1
Reif, K.2
Smith, G.3
Sansom, D.M.4
Hemmings, B.A.5
-
36
-
-
0032832476
-
Adaptive increase of amino acid transport system A requires ERK1/2 activation
-
Franchi-Gazzola R, Visigalli R, Bussolati O, Dall'Asta V, Gazzola GC (1999) Adaptive increase of amino acid transport system A requires ERK1/2 activation. J Biol Chem 274: 28922-28928.
-
(1999)
J Biol Chem
, vol.274
, pp. 28922-28928
-
-
Franchi-Gazzola, R.1
Visigalli, R.2
Bussolati, O.3
Dall'asta, V.4
Gazzola, G.C.5
-
37
-
-
0037825710
-
The osmoregulatory and the amino acid-regulated responses of system A are mediated by different signal transduction pathways
-
Lopez-Fontanals M, Rodriguez-Mulero S, Casado FJ, Derijard B, Pastor-Anglada M (2003) The osmoregulatory and the amino acid-regulated responses of system A are mediated by different signal transduction pathways. J Gen Physiol 122: 5-16.
-
(2003)
J Gen Physiol
, vol.122
, pp. 5-16
-
-
Lopez-Fontanals, M.1
Rodriguez-Mulero, S.2
Casado, F.J.3
Derijard, B.4
Pastor-Anglada, M.5
-
38
-
-
34547124353
-
Distinct sensor pathways in the hierarchical control of SNAT2, a putative amino acid transceptor, by amino acid availability
-
Hyde R, Cwiklinski EL, MacAulay K, Taylor PM, Hundal HS (2007) Distinct sensor pathways in the hierarchical control of SNAT2, a putative amino acid transceptor, by amino acid availability. J Biol Chem 282: 19788-19798.
-
(2007)
J Biol Chem
, vol.282
, pp. 19788-19798
-
-
Hyde, R.1
Cwiklinski, E.L.2
Macaulay, K.3
Taylor, P.M.4
Hundal, H.S.5
-
39
-
-
14444279192
-
Identification of a novel inhibitor of mitogen-activated protein kinase kinase
-
Favata MF, Horiuchi KY, Manos EJ, Daulerio AJ, Stradley DA, et al. (1998) Identification of a novel inhibitor of mitogen-activated protein kinase kinase. J Biol Chem 273: 18623-18632.
-
(1998)
J Biol Chem
, vol.273
, pp. 18623-18632
-
-
Favata, M.F.1
Horiuchi, K.Y.2
Manos, E.J.3
Daulerio, A.J.4
Stradley, D.A.5
-
40
-
-
0028988138
-
SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
-
Cuenda A, Rouse J, Doza YN, Meier R, Cohen P, et al. (1995) SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1. FEBS Lett 364: 229-233.
-
(1995)
FEBS Lett
, vol.364
, pp. 229-233
-
-
Cuenda, A.1
Rouse, J.2
Doza, Y.N.3
Meier, R.4
Cohen, P.5
-
41
-
-
57049132739
-
Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c
-
Vaughn AE, Deshmukh M (2008) Glucose metabolism inhibits apoptosis in neurons and cancer cells by redox inactivation of cytochrome c. Nat Cell Biol 10: 1477-1483.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 1477-1483
-
-
Vaughn, A.E.1
Deshmukh, M.2
-
42
-
-
0028884033
-
PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
-
Alessi DR, Cuenda A, Cohen P, Dudley DT, Saltiel AR (1995) PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 270: 27489-27494.
-
(1995)
J Biol Chem
, vol.270
, pp. 27489-27494
-
-
Alessi, D.R.1
Cuenda, A.2
Cohen, P.3
Dudley, D.T.4
Saltiel, A.R.5
-
43
-
-
17044422629
-
Glucose availability regulates IFN-gamma production and p70S6 kinase activation in CD8+ effector T cells
-
Cham CM, Gajewski TF (2005) Glucose availability regulates IFN-gamma production and p70S6 kinase activation in CD8+ effector T cells. J Immunol 174: 4670-4677.
-
(2005)
J Immunol
, vol.174
, pp. 4670-4677
-
-
Cham, C.M.1
Gajewski, T.F.2
-
44
-
-
0034983918
-
Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase
-
Gottlob K, Majewski N, Kennedy S, Kandel E, Robey RB, et al. (2001) Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes Dev 15: 1406-1418.
-
(2001)
Genes Dev
, vol.15
, pp. 1406-1418
-
-
Gottlob, K.1
Majewski, N.2
Kennedy, S.3
Kandel, E.4
Robey, R.B.5
-
45
-
-
0141863388
-
Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival
-
Rathmell JC, Fox CJ, Plas DR, Hammerman PS, Cinalli RM, et al. (2003) Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. Mol Cell Biol 23: 7315-7328.
-
(2003)
Mol Cell Biol
, vol.23
, pp. 7315-7328
-
-
Rathmell, J.C.1
Fox, C.J.2
Plas, D.R.3
Hammerman, P.S.4
Cinalli, R.M.5
|