Hypoxia and acidosis independently up-regulate vascular endothelial growth factor transcription in brain tumors in vivo

Cancer Research

Volumn 61, Issue 16, 2001, Pages 6020-6024

  Fukumura, D ^a   Xu, L ^a   Chen, Y ^a   Gohongi, T ^a   Seed, B ^a   Jain, R K ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VASCULOTROPIN;

ACIDOSIS; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRAIN TUMOR; CONTROLLED STUDY; GENETIC TRANSCRIPTION; GLIOMA CELL; HUMAN; HUMAN CELL; HYPOXIA; MOUSE; NONHUMAN; OXYGEN TISSUE LEVEL; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; SCID MOUSE; TRANSCRIPTION REGULATION;

ACIDOSIS; BRAIN NEOPLASMS; CELL HYPOXIA; ENDOTHELIAL GROWTH FACTORS; GENE EXPRESSION REGULATION, NEOPLASTIC; GREEN FLUORESCENT PROTEINS; HYDROGEN-ION CONCENTRATION; LUMINESCENT PROTEINS; LYMPHOKINES; OXYGEN; PARTIAL PRESSURE; PROMOTER REGIONS (GENETICS); RECOMBINANT FUSION PROTEINS; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0035881307     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy
2. 2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation
3. Tumor hypoxia and gene expression - Implications for malignant progression and therapy
4. The relevance of tumor pH to the treatment of malignant disease
5. Acid pH in tumors and its potential for therapeutic exploitation
6. Angiogenesis in cancer and other diseases: From genes to function to therapy
7. 2 homeostasis by hypoxia-inducible factor 1
8. VEGF expression in tumors is regulated by oxygen gradient rather than absolute level of hypoxia itself
9. Hypoxia and vascular endothelial growth factor expression in human squamous cell carcinoma using pimonidazole as a hypoxia marker
10. Acidosis inhibits endothelial cell apoptosis and function and induces basic fibroblast growth factor and vascular endothelial growth factor expression
11. Blockade of nuclear factor-κB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8
12. Tumor induction of VEGF promoter in stromal cells
13. In vivo measurement of gene expression, angiogenesis, and physiological function in tumors using multiphoton laser scanning microscopy
14. Acidic pH-induced elevation in interleukin 8 expression by human ovarian carcinoma cells
15. Vascular permeability and microcirculation of gliomas and mammary carcinomas transplanted in rat and mouse cranial window
16. Fluorescence ratio imaging and optical sectioning: Effect of glucose on spatial and temporal gradients
17. Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice
18. Low environmental pH is responsible for the induction of nitric-oxide synthase in macrophages. Evidence for involvement of nuclear factor-κB activation
19. Regulation of vascular endothelial growth factor expression by acidosis in human cancer cells
20. Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia inducible factor-1α→Hypoxia response element → VEGF cascade differentially regulates vascular response and growth rate in tumors
21. Role of tumor-host interactions in interstitial diffusion of macromolecules: Cranial vs. subcutaneous tumors
22. Cellular pH gradient in tumor versus normal tissue: Potential exploitation for the treatment of cancer
23. Death of tumor cells after intracellular acidification is dependent on stress-activated protein kinases (SAPK/JNK) pathway activation and cannot be inhibited by Bcl-2 expression or interleukin 1β-converting enzyme inhibition
24. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
25. Heterogeneous vascular dependence of tumor cell populations