The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

Cell Metabolism

Volumn 7, Issue 1, 2008, Pages 11-20

  DeBerardinis, Ralph J ^a,b   Lum, Julian J ^a   Hatzivassiliou, Georgia ^a   Thompson, Craig B ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; CITRIC ACID; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GLUTAMINE; GROWTH FACTOR; HYPOXIA INDUCIBLE FACTOR 1; MAMMALIAN TARGET OF RAPAMYCIN; MYC PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN KINASE B BETA; PYRUVATE CARBOXYLASE; SUCCINATE DEHYDROGENASE;

ACUTE LYMPHOCYTIC LEUKEMIA; ANAEROBIC GLYCOLYSIS; BREAST CANCER; CANCER GROWTH; CARCINOGENESIS; CELL ACTIVITY; CELL CYCLE G1 PHASE; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CELL GROWTH; CELL METABOLISM; CELL PROLIFERATION; CHRONIC MYELOID LEUKEMIA; CITRIC ACID CYCLE; COLON CANCER; ENZYME ACTIVITY; ENZYME ANALYSIS; FATTY ACID SYNTHESIS; GENE EXPRESSION REGULATION; GENE IDENTIFICATION; GENE MUTATION; GLIOMA; GLUCOSE METABOLISM; HEAD AND NECK CANCER; HEPATOMA CELL; HUMAN; HYPOXIA; LIPID OXIDATION; LIPOGENESIS; LUNG NON SMALL CELL CANCER; METABOLIC REGULATION; MUTATIONAL ANALYSIS; NEOPLASM; NONHUMAN; OVARY CANCER; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL PROLIFERATION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; MODELS, BIOLOGICAL; NEOPLASMS; SIGNAL TRANSDUCTION;

EID: 37449024702     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2007.10.002     Document Type: Review

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