Metabolic reprogramming of cancer-associated fibroblasts by TGF-β drives tumor growth: Connecting TGF-β signaling with "Warburg- like" cancer metabolism and L-lactate production

Cell Cycle

Volumn 11, Issue 16, 2012, Pages 3019-3035

  Guido, Carmela ^a,b,c   Whitaker Menezes, Diana ^a,b   Capparelli, Claudia ^a,b,c   Balliet, Renee ^a,b   Lin, Zhao ^a,b   Pestell, Richard G ^a,b   Howell, Anthony ^d   Aquila, Saveria ^c   Ando, Sebastiano ^c   Martinez Outschoorn, Ubaldo ^a,b   Sotgia, Federica ^a,b,d   Lisanti, Michael P ^a,b,d  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c UNIVERSITY OF CALABRIA   (Italy)

^d UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Aerobic glycolysis; Autocrine signaling; Autophagy; Cancer associated fibroblast; Cancer metabolism; Mitophagy; Myofibroblast; Oxidative stress; Paracrine signaling; Pied Piper of Hamelin; TGF beta; The field effect; Tumor stroma

Indexed keywords

CAVEOLIN 1; LACTIC ACID; LIGAND; TRANSFORMING GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; AUTOPHAGY; BREAST CANCER; CANCER CELL; CANCER GROWTH; CARCINOGENESIS; CATABOLISM; CELL ACTIVATION; CELL TYPE; CONTROLLED STUDY; DOWN REGULATION; FIBROBLAST; GLYCOLYSIS; HUMAN; HUMAN CELL; INFORMATION PROCESSING; INTRACELLULAR SIGNALING; MITOCHONDRION; MITOPHAGY; MOUSE; MYOFIBROBLAST; NONHUMAN; OXIDATIVE STRESS; PARACRINE SIGNALING; PROTEIN EXPRESSION; STROMA CELL; TUMOR MICROENVIRONMENT; TUMOR XENOGRAFT;

EID: 84865335195     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.21384     Document Type: Article

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