Radiosensitization of Murine Ehrlich ascites tumor by a combination of 2-deoxy-D-glucose and 6-aminonicotinamide

Technology in Cancer Research and Treatment

Volumn 3, Issue 6, 2004, Pages 659-663

  Varshney, R ^a   Gupta, S ^a,b   Dwarakanath, B S ^a  

^a INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

2 deoxy D Glucose (2 DG); 6 aminonicotinamide (6 AN); Cure rate; Ehrlich Ascites Tumor (EAT)

Indexed keywords

6 AMINONICOTINAMIDE; DEOXYGLUCOSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASCITES TUMOR; CANCER RADIOTHERAPY; CANCER SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; IRRADIATION; MALE; MOUSE; MOUSE STRAIN; NONHUMAN; RADIATION RESPONSE; RADIOSENSITIZATION; TUMOR GROWTH; TUMOR REGRESSION;

EID: 11144323811     PISSN: 15330346     EISSN: None     Source Type: Journal    
DOI: 10.1177/153303460400300616     Document Type: Article

References (31)

1. Weichselbaum, R. R., Beckett, M. A., Schwartz, J. L., and Dritchilo, A. A. Radioresistant Tumour Cells are Present in Head and Neck Carcinoma that Recurs After Irradiation. Int. J. Radiat. Oncol. Biol. & Phys. 15, 575-579 (1988).
2. Suit, H. D., Baumann, M., Skates, S., and Convery, K. Clinical Interest in Determinations of Cellular Radiosensitivity. Int. J. Radiat. Biol. 56, 725-737 (1989).
3. Kasid, U., Pirollo, K., Dritschilo, A., and Chang, E. Oncogenic Basis of Radioresistance. Adv. Cancer Res. 61, 195-233 (1993).
4. Spitz, D. R., Sim, J. E., Ridnour, L. A., Galoforo, S. S., and Lee, Y. J. Glucose Deprivation Induced Oxidative Stress in Tumor Cells: A Fundamental Defect in Metabolism. NY Acad. Sci. 899, 349-362 (2000).
5. Woodward, G. E., and Cramer F. B. 2-deoxy-D-glucose as an Inhibitor of Anaerobic Glycolysis in Tumor Tissue. J. Franklin Institute 254, 259-260 (1952).
6. Dwarakanath, B. S. and Jain, V. K. Energy Linked Modification of the Radiation Response in a Human Cerebral Glioma Cell Line. Int J. Radiat. Oncol. Biol. Phys. 17, 1033-1040 (1989).
7. Dwarakanath, B. S. and Jain, V. K. Effects of Gamma-rays and Glucose Analogue on the Energy Metabolism of Cell Line Derived from Cerebral Glioma. Ind. J. Biochem. Biophys. 28, 203-209 (1991).
8. Kalia, V. K. Optimizing Radiation Therapy of Brain Tumors by Combination of 5-Bromo 2-deoxy Uridine and 2-deoxy-D-glucose. Ind. J. Med. Res. 109, 182-197 (1999).
9. Lin, X., Zhang, F., Bradbury, C. M., Kaushal, A., Liv, L., Spitz, D. R., Aft, R. L., and Guis, D. 2-Deoxy-D-glucose Cytotoxicity and Radiosensitization in Tumor Cells is Mediated via Disruptions of Thiol Metabolism. Cancer Res. 63, 3413-3417 (2003)
10. Dwarakanath, B. S. and Jain, V. K. Modification of Radiation Induced Damage by 2-Deoxy-D-glucose in Organ Cultures of Human Cerebral Glioma. Int. J. Radiat. Oncol. Biol. Phys. 13, 741-746 (1987)
11. Jain, V., Porschen, W., and Feinendegen, L. E. Optimization of Cancer Therapy: Part II. Effects of Combining 2-Deoxy-D-glucose Treatment with Gamma Irradiation on Sarcoma-180. Ind. J. Exp. Biol. 15, 714-718 (1977).
12. Dwarakanath, B. S., Singh, S., and Jain, V. Optimization of Tumor Radiotherapy: Part V - Radiosensitization by 2-Deoxy-D glucose and DNA Ligand Hoechst-33342 in Murine Tumour. Ind. J. Exp. Biol. 37, 865-870 (1999).
13. Kalia, V. K., Jain, V. K., and Otto, F. J. Optimization of Cancer Therapy IV. Effects of 2-Deoxy-D-glucose on Radiation Induced Chromosomal Damage in PHA Stimulated Peripheral Leukocytes. Ind. J. Exp. Biol. 20, 884-888 (1982).
14. Singh, S. P., Singh, S., and Jain, V. Effects of 5-Bromo-Deoxy-Uridine and 2-Deoxy-D-glucose on Radiation-induced Micronuclei in Mouse Bone Marrow. Int. J. Radiat. Biol. 58, 791-797 (1990).
15. Mohanti, B. K., Rath, G. K., Anantha, N., Kannan, V., Das, B. S., Chandramuli, A. R., Banerjee, A. K., Das, S., Jena, A., Ravichandran, R., Sahi, U. P., Kumar, R., Kapoor, N., Kalia, V. K., Dwarakanath, B. S., and Jain, V. Improving Cancer Radiotherapy With 2-Deoxy-D-glucose: Phase I/II Clinical Trials on Human Cerebral Gliomas. Int. J. Radiat. Oncol. Biol. Phys. 35, 103-111 (1996).
16. Dwarakanath, B. S., Zolzer, F., Chandana, S., Bauch, T., Adhikari, J. S., Muller, W., Streffer, C., and Jain, V. Heterogeneity in 2-Deoxy-D-glucose Induced Modification of Radiation Response in Human Tumor Cell Lines. Int. J. Radiat. Oncol. Biol. Phys. 50, 1051-1061 (2001).
17. Jha, B. and Pohlit, W. Reversibility of Inhibition of DNA Double Strand Break Repair by 2-Dexoy-D-glucose in Ehrlich Ascites Tumor Cells. Int. J. Radiat. Biol. 63, 459-467 (1993).
18. Dwarakanath, B. S., Adhikari, J. S., and Jain V. Hematoporphyrin Derivatives Potentiate the Radiosensitizing Effects of 2-DG in Cancer Cells. Int. J. Radiat. Oncol. Biol. Phys. 13, 183-188 (1999).
19. 31P-magnetic Resonance Spectroscopic Study. BBRC 164, 947-953 (1989).
20. Sharma, R. K., Hansum, H., and Jain, V. NMR Spectroscopic Studies on the Bioenergetic Changes Induced by Metabolic Modulators in Ehrlich Ascites Tumor Cells. Ind. J. Biochem. Biophys. 33, 122-130 (1996).
21. Street, J. C., Alferi, A. A., and Koutcher, J. A. Quantitation of Metabolic and Radiobiological Effects of 6-Aminonicotinamide in RIF-1 Tumour Cells In Vitro. Cancer Res. 57, 3956-3962 (1997).
22. Berger, N. A., Catino, D. M., and Vietti, T. J. Synergistic Antileukemic Effect of 6-Aminonicotinamide and 1, 3 bis(2-chloroethyl)-1-nitrosourea on LI210 Cells In Vitro and In Vivo. Cancer Res. 42, 4382-4386 (1982).
23. Ames, M. M., Walker, D. L., Reid, J. M., Svingen, P. A., Budhihardjo, I., Kaufmann, S. H., Covey, J. M., Alley, M. C., and Hollingshed, M. G. 6-Aminonicotinamide: Murine Plasma Pharmacokinetics and Modulation of Drug Resistance. Proceed American Assoc Cancer Res 37, 1965 (1996).
24. (UKCCCR) GUIDELINES: United Kingdom Coordinating Committee on Cancer Research Guidelines for the Welfare of Animals in Experimental Oncology. B.J. Cancer 77, 1-10 (1998).
25. Varshney, R., Adhikari, J. S., and Dwarakanath, B. S. Contribution of Oxidative Stress to Radiosensitization by a Combination of 2-DG and 6-AN in Human Cancer Cell Line. Ind. J. Exp. Biol. 47, 1384-1391 (2003).
26. Landau, B. R., Laszlo, J., Stengle, J., and Bruk, D. Certain Metabolic and Pharmologic Effects in Cancer Patients Given Infusion of 2-Deoxy-D-glucose. J. Nat. Cancer. Instit. 21, 485-494 (1958).
27. Meldrum, B. S. and Horton, R. W. Cerebral Functional Effects of 2-DG and 3-O-Methylglucose in Rhesus Monkeys. EEG Clin. Neurophysiol. 35, 59-66 (1973).
28. Thompson, D. A., Campbell, R. G., and Lilavivavathana, U. Increased Thirst and Plasma Arginine Vasopressin Levels During 2-DG Induced Glucodeprivation in Humans. J. Clin. Investig. 67, 1083-1093 (1981).
29. Herter, F. P., Weissman, S. G., Thompson, H. G., Hyman, G., and Martin, D. S. Clinical Experience with 6-Aminonicotinamide. Cancer Res. 21, 31-37 (1961).
30. Walker, D. L., Reid, J. M., Svingen, P. A., Rios, R., Covey, J. M., Alley, M. C., Hollingshed, M. G., Budihardjo, I. I., Eckdahl, S., Boerner, S. A., Kaufmann, S. H., and Ames, M. M. Murine Pharmacokinetics of 6-Aminonicotinamide (NSC 21206). A Novel Biochemical Modulating Agent. Biochem. Pharmacol. 58, 1057-1066 (1999).
31. Life Sciences and Biotechnoloy Update, August, 2001. Breast Cancer Therapy Enhancement by 6-Aminonicotinamide. Internet site.