Tumor microenvironmental physiology and its implications for radiation oncology

Seminars in Radiation Oncology

Volumn 14, Issue 3, 2004, Pages 198-206

  Vaupel, Peter ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GROWTH FACTOR; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; TRANSCRIPTION FACTOR;

ANTIANGIOGENIC ACTIVITY; CANCER EPIDEMIOLOGY; CANCER INHIBITION; CANCER RADIOTHERAPY; CANCER RECURRENCE; CLONAL VARIATION; DNA DAMAGE; GENETIC HETEROGENEITY; GENETIC STABILITY; HIGH RISK PATIENT; HUMAN; HYPOXIA; MICROCIRCULATION; MITOSIS INHIBITION; NONHUMAN; ONCOLOGY; PATIENT SELECTION; PRIORITY JOURNAL; RADIATION RESPONSE; RADIOSENSITIVITY; REVIEW; TISSUE PRESSURE; TREATMENT FAILURE; TUMOR BLOOD FLOW; TUMOR GROWTH; TUMOR VASCULARIZATION;

EID: 3142587028     PISSN: 10534296     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.semradonc.2004.04.008     Document Type: Article

References (55)

1. Sutherland R.M. Cell and environment interactions in tumor microregions The multicell spheroid model. Science. 240:1988;177-184
2. Vaupel P., Kallinowski F., Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors A review. Cancer Res. 49:1989;6449-6465
3. Vaupel P., Jain R.K. Tumor Blood Supply and Metabolic Microenvironment. Characterization and Implications for Therapy. 1991;Fischer, Stuttgart
4. Vaupel P. Physiological properties of malignant tumours. NMR Biomed. 5:1992;220-225
5. Vaupel P. Blood flow and metabolic microenvironment of brain tumors. J Neuro-Oncol. 22:1994;261-267
6. Vaupel P.W. Blood Flow, Oxygenation, Tissue pH Distribution, and Bioenergetic Status of Tumors. Lecture 23. 1994;Ernst Schering Research Foundation
7. Vaupel P., Thews O., Höckel M. Durchblutung, Oxygenierung, pH-Verteilung und Bioenergetischer Status maligner Tumoren. Arzneimitteltherapie. 15:1997;319-327
8. Vaupel P., Kelleher D.K. Tumor Hypoxia. 1999;Wissenschaftliche Verlagsgesellschaft, Stuttgart
9. Vaupel P., Höckel M. Blood supply, oxygenation status and metabolic micromilieu of breast cancers Characterization and therapeutic relevance. Int J Oncol. 17:2000;869-879
10. Molls M., Vaupel P. Blood Perfusion and Microenvironment of Human Tumors. 2000;Springer, New York, NY
11. Bussink J. The Tumor Microenvironment and Effects of Hypoxia Modification. 2000;Proefschrift, Katholieke Universiteit, Nijmegen
12. Goode J.A., Chadwick D.J. The Tumour Microenvironment Causes and Consequences of Hypoxia and Acidity. 2001;John Wiley & Sons, LTD, New York, NY. Novartis Foundation Symposium 240, Chichester
13. Sivridis E., Giatromanolaki A., Koukourakis M.I. The vascular network of tumours - What is it not for? J Pathol. 201:2003;173-180
14. Ribatti D., Vacca A., Dammacco F. New non-angiogenesis dependent pathways for tumour growth. Eur J Cancer. 39:2003;1835-1841
15. Gillies R.J., Schornack P.A., Secomb T.W., et al. Causes and effects of heterogeneous perfusion in tumors. Neoplasia. 1:1999;197-207
16. Vaupel P., Thews O., Hoeckel M. Treatment resistance of solid tumors Role of hypoxia and anemia. Med Oncol. 18:2001;243-259
17. 2 extraction is a key parameter determining the oxygenation status of malignant tumors and normal tissues. Int J Oncol. 22:2003;795-798
18. Konerding M.A., Fait E., Gaumann A. 3D microvascular architecture of pre-cancerous lesions and invasive carcinomas of the colon. Br J Cancer. 84:2001;1354-1362
19. Kimura H., Braun R.D., Ong E.T., et al. Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma. Cancer Res. 56:1996;5522-5528
20. Baronzio G., Freitas I., Kwaan H.C. Tumor microenvironment and hemorheological abnormalities. Semin Thrombosis Hemostasis. 29:2003;489-497
21. Jain R.K. Barriers to drug delivery in solid tumors. Sci Am. 271:1994;58-65
22. Vaupel P., Höckel M. Tumor hypoxia and therapeutic resistance. Nowrousian M.R. Recombinant Human Erythropoietin (rhEPO) in Clinical Oncology. 2002;127-146 Springer, New York, NY
23. Vaupel P., Briest S., Höckel M. Hypoxia in breast cancer Pathogenesis, characterization and biological/therapeutic implications. Wien Med Wschr. 152:2002;334-342
24. Vaupel P., Mayer A., Höckel M. Tumor hypoxia and malignant progression. Methods Enzymol. 381:2004;335-354
25. i. NMR Biomed. 7:1994;128-136
26. + exchanger in cancer angiogenesis and antiangiogenesis. Br J Cancer. 89:2003;1395-1399
27. Griffiths J.R. Are cancer cells acidic? Br J Cancer. 64:1991;425-427
28. Gullino P.M. Techniques for the study of tumor physiopathology. Busch H. Methods in Cancer Research. vol 5:1970;45-91 Academic Press, New York, NY
29. Walenta S., Chau T.-V., Schroeder T., et al. Metabolic classification of human rectal adenocarcinomas a novel guideline for clinical oncologists? J Cancer Res Clin Oncol. 129:2003;321-326
30. Walenta S., Wetterling M., Lehrke M., et al. High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers. Cancer Res. 60:2000;916-921
31. Walenta S., Salameh A., Lyng H., et al. Correlation of high lactate levels in head and neck tumors with incidence of metastasis. Am J Pathol. 150:1997;409-415
32. Vaupel P., Mayer A., Briest S., et al. Oxygenation gain factor A novel parameter characterizing the association between hemoglobin level and the oxygenation status of breast cancers. Cancer Res. 63:2003;7634-7637
33. Vaupel P., Thews O., Mayer A., et al. Oxygenation status of gynecologic tumors What is the optimal hemoglobin level? Strahlenther Onkol. 178:2002;727-731
34. Becker A., Stadler P., Lavey R.S., et al. Severe anemia is associated with poor tumor oxygenation in head and neck squamous cell carcinomas. Int J Radiat Oncol Biol Phys. 46:2000;459-466
35. Höckel M., Vaupel P. Tumor hypoxia Definitions and current clinical, biologic and molecular aspects. J Natl Cancer Inst. 93:2001;266-276
36. Giaccia A.J. Hypoxic stress proteins Survival of the fittest. Semin Radiat Oncol. 6:1996;46-58
37. Höckel M., Schlenger K., Aral B., et al. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res. 56:1996;4509-4515
38. Höckel M., Schlenger K., Höckel S., et al. Tumor hypoxia in pelvic recurrences of cervical cancer. Int J Cancer. 79:1998;365-369
39. Cuvier C., Jang A., Hill R.P. Exposure to hypoxia, glucose starvation and acidosis Effect on invasive capacity of murine tumor cells and correlation with cathepsin (L+B) secretion. Clin Exp Metastasis. 15:1997;19-25
40. Höckel M., Schlenger K., Höckel S., et al. Hypoxic cervical cancers with low apoptotic index are highly aggressive. Cancer Res. 59:1999;4525-4528
41. Brizel D.M., Scully S.P., Harrelson J.M., et al. Tumor oxygenation predicts for the likelihood of distant metastases in human soft tissue sarcoma. Cancer Res. 56:1996;941-943
42. Rofstad E.K. Microenvironment-induced cancer metastasis. Int J Radiat Biol. 76:2000;589-605
43. Subarsky P., Hill R.P. The hypoxic tumour microenvironment and metastatic progression. Clin Exp Metastasis. 20:2003;237-250
44. Gray L.H., Conger A.D., Ebert M., et al. The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol. 26:1953;638-648
45. Yuan J., Glazer P.M. Mutagenesis induced by the tumor microenvironment. Mutation Res. 400:1998;439-446
46. Nowell P.C. The clonal evolution of tumor cell populations. Science. 194:1976;23-28
47. Yuan J., Narayanan L., Rockwell S., et al. Diminished DNA repair and elevated mutagenesis in mammalian cells exposed to hypoxia and low pH. Cancer Res. 60:2000;4372-4376
48. Reynolds T.Y., Rockwell S., Glazer P.M. Genetic instability induced by the tumor microenvironment. Cancer Res. 56:1996;5754-5757
49. Stubbs M., McSheehy P.M.J., Griffiths J.R., et al. Causes and consequences of tumour acidity and implications for treatment. Mol Med Today. 6:2000;15-19
50. Evans S.M., Koch C.J. Prognostic significance of tumor oxygenation in humans. Cancer Lett. 195:2003;1-16
51. Vordermark D., Brown J.M. Endogenous markers of tumor hypoxia. Strahlenther Onkol. 12:2003;801-811
52. Mayer A, Wree A, Höckel M, et al. Lack of correlation between expression of HIF-1α protein and oxygenation status in identical tissue areas of squamous cell carcinomas of the uterine cervix. Cancer Res (in press)
53. Coleman C.N., Mitchell J.B., Camphausen K. Tumor hypoxia Chicken, egg, or a piece of the farm? J Clin Oncol. 20:2002;610-615
54. Okunieff P., Ding I., Vaupel P., et al. Evidence for and against hypoxia as the primary cause of tumor aggressiveness. Adv Exp Med Biol. 510:2003;69-75
55. Brizel D.M., Schroeder T., Scher R.L., et al. Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer. Int J Radiat Oncol Biol Phys. 51:2001;349-353