Regulatory role of p53 in cancer metabolism via SCO2 and TIGAR in human breast cancer

Human Pathology

Volumn 43, Issue 2, 2012, Pages 221-228

  Won, Kyu Yeoun ^a   Lim, Sung Jig ^b   Kim, Gou Young ^b   Kim, Youn Wha ^a   Han, Sang Ah ^b   Song, Jeong Yoon ^b   Lee, Dong Ki ^c  

^a Kyung Hee University Hospital   (South Korea)

^b Kyung Hee University College of Medicine   (South Korea)

^c Sejong Science High School   (South Korea)

Author keywords

Breast carcinoma; COX; p53; SCO2; TIGAR

Indexed keywords

MEMBRANE PROTEIN; P53 TRANSACTIVATED TP53 INDUCED GLYCOLYSIS; PROTEIN P53; SYNTHESIS OF CYTOCHROME C OXIDASE 2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BREAST CANCER; BREAST CARCINOMA; CANCER INVASION; CANCER PATIENT; DISEASE ASSOCIATION; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MICROARRAY ANALYSIS; PROGNOSIS; PROTEIN EXPRESSION; PROTEIN METABOLISM;

BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CARRIER PROTEINS; ELECTRON TRANSPORT COMPLEX IV; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P53; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MIDDLE AGED; MITOCHONDRIAL PROTEINS; NEOPLASM GRADING; SURVIVAL RATE; TISSUE ARRAY ANALYSIS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84855991449     PISSN: 00468177     EISSN: 15328392     Source Type: Journal    
DOI: 10.1016/j.humpath.2011.04.021     Document Type: Article

References (22)

1. B. Vogelstein, D. Lane, and A.J. Levine Surfing the p53 network Nature 408 2000 307 310
2. S. Matoba, J.G. Kang, and W.D. Patino p53 regulates mitochondrial respiration Science 312 2006 1650 1653 (Pubitemid 43902663)
3. K. Bensaad, and K.H. Vousden p53: new roles in metabolism Trends Cell Biol 17 2007 286 291 (Pubitemid 46829848)
4. R.A. Harris, M.M. Bowker-Kinley, and B. Huang Regulation of the activity of the pyruvate dehydrogenase complex Adv Enzyme Regul 42 2002 249 259 (Pubitemid 35033542)
5. P.C. Herrmann, J.W. Gillespie, and L. Charboneau Mitochondrial proteome: altered cytochrome c oxidase subunit levels in prostate cancer Proteomics 3 2003 1801 1810 (Pubitemid 37129826)
6. S. Zhou, S. Kachhap, and K.K. Singh Mitochondrial impairment in p53-deficient human cancer cells Mutagenesis 18 2003 287 292 (Pubitemid 36592423)
7. K. Bensaad, A. Tsuruta, and M.A. Selak TIGAR, a p53-inducible regulator of glycolysis and apoptosis Cell 126 2006 107 120 (Pubitemid 44040989)
8. C.V. Dang, and G.L. Semenza Oncogenic alterations of metabolism Trends Biochem Sci 24 1999 68 72 (Pubitemid 29346576)
9. O. Warburg On respiratory impairment in cancer cells Science 124 1956 269 270
10. N.C. Denko, L.A. Fontana, and K.M. Hudson Investigating hypoxic tumor physiology through gene expression patterns Oncogene 22 2003 5907 5914 (Pubitemid 37176711)
11. H. Kondoh, M.E. Lleonart, and J. Gil Glycolytic enzymes can modulate cellular life span Cancer Res 65 2005 177 185 (Pubitemid 40070808)
12. D.R. Plas, and C.B. Thompson Akt-dependent transformation: there is more to growth than just surviving Oncogene 24 2005 7435 7442 (Pubitemid 41637983)
13. J.W. Kim, K.I. Zeller, and Y. Wang Evaluation of myc E-box phylogenetic footprints in glycolytic genes by chromatin immunoprecipitation assays Mol Cell Biol 24 2004 5923 5936 (Pubitemid 38787976)
14. F. Schwartzenberg-Bar-Yoseph, M. Armoni, and E. Karnieli The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression Cancer Res 64 2004 2627 2633 (Pubitemid 38523921)
15. R.J. Gillies, and R.A. Gatenby Adaptive landscapes and emergent phenotypes: why do cancers have high glycolysis? J Bioenerg Biomembr 39 2007 251 257 (Pubitemid 47619378)
16. T. Bui, and C.B. Thompson Cancer's sweet tooth Cancer Cell 9 2006 419 420 (Pubitemid 43832194)
17. C.D. Young, and S.M. Anderson Sugar and fat-that's where it's at: metabolic changes in tumors Breast Cancer Res 10 2008 202
18. V.R. Fantin, J. St-Pierre, and P. Leder Attenuation of LDH-A expression uncovers a link between glycolysis, mitochondrial physiology, and tumor maintenance Cancer Cell 9 2006 425 434 (Pubitemid 43832190)
19. Y.H. Ko, B.L. Smith, and Y. Wang Advanced cancers: eradication in all cases using 3-bromopyruvate therapy to deplete ATP Biochem Biophys Res Commun 324 2004 269 275 (Pubitemid 39311489)
20. S.P. Mathupala, Y.H. Ko, and P.L. Pedersen Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria Oncogene 25 2006 4777 4786 (Pubitemid 44187625)
21. S. Bonnet, S.L. Archer, and J. Allalunis-Turner A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth Cancer Cell 11 2007 37 51 (Pubitemid 46054520)
22. H. Pelicano, D.S. Martin, and R.H. Xu Glycolysis inhibition for anticancer treatment Oncogene 25 2006 4633 4646 (Pubitemid 44187614)