-
3
-
-
0036279840
-
T-cell activation through the antigen receptor. Part 2: Role of signaling cascades in T-cell differentiation, anergy, immune senescence, and development of immunotherapy
-
Andre E.N., Ndaisha S. T-cell activation through the antigen receptor. Part 2: Role of signaling cascades in T-cell differentiation, anergy, immune senescence, and development of immunotherapy. J Allerg Clin Immunol 2002, 109:901-915.
-
(2002)
J Allerg Clin Immunol
, vol.109
, pp. 901-915
-
-
Andre, E.N.1
Ndaisha, S.2
-
4
-
-
84865300719
-
Metabolism and autophagy in the immune system: immunometabolism comes of age
-
Rathmell J.C. Metabolism and autophagy in the immune system: immunometabolism comes of age. Immunol Rev 2012, 249:5-13.
-
(2012)
Immunol Rev
, vol.249
, pp. 5-13
-
-
Rathmell, J.C.1
-
5
-
-
0021792065
-
The role of high rates of glycolysis and glutamine utilization in rapidly dividing cells
-
Newsholme E.A., Crabtree B., Ardawi M.S. The role of high rates of glycolysis and glutamine utilization in rapidly dividing cells. Biosci Rep 1985, 5:393-400.
-
(1985)
Biosci Rep
, vol.5
, pp. 393-400
-
-
Newsholme, E.A.1
Crabtree, B.2
Ardawi, M.S.3
-
6
-
-
84859140799
-
Metabolic pathways in T cell fate and function
-
Gerriets V.A., Rathmell J.C. Metabolic pathways in T cell fate and function. Trends Immunol 2012, 33:168-173.
-
(2012)
Trends Immunol
, vol.33
, pp. 168-173
-
-
Gerriets, V.A.1
Rathmell, J.C.2
-
7
-
-
66249108601
-
Understanding the Warburg effect: the metabolic requirements of cell proliferation
-
Vander Heiden M.G., Cantley L.C., Thompson C.B. Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 2009, 324:1029-1033.
-
(2009)
Science
, vol.324
, pp. 1029-1033
-
-
Vander Heiden, M.G.1
Cantley, L.C.2
Thompson, C.B.3
-
8
-
-
34848913375
-
T cell activation requires mitochondrial translocation to the immunological synapse
-
Quintana A., Schwindling C., Wenning A.S., Becherer U., Rettig J., Schwarz E.C., Hoth M. T cell activation requires mitochondrial translocation to the immunological synapse. Proc Natl Acad Sci U S A 2007, 104:14418-14423.
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 14418-14423
-
-
Quintana, A.1
Schwindling, C.2
Wenning, A.S.3
Becherer, U.4
Rettig, J.5
Schwarz, E.C.6
Hoth, M.7
-
9
-
-
84870462073
-
T cell activation is driven by an ADP-dependent glucokinase linking enhanced glycolysis with mitochondrial reactive oxygen species generation
-
Kamiński Marcin M., Sauer Sven W., Kamiński M., Opp S., Ruppert T., Grigaravičius P., Grudnik P., Gröne H.-J., Krammer Peter H., Gülow K. T cell activation is driven by an ADP-dependent glucokinase linking enhanced glycolysis with mitochondrial reactive oxygen species generation. Cell Rep 2012, 2:1300-1315.
-
(2012)
Cell Rep
, vol.2
, pp. 1300-1315
-
-
Kamiński Marcin, M.1
Sauer Sven, W.2
Kamiński, M.3
Opp, S.4
Ruppert, T.5
Grigaravičius, P.6
Grudnik, P.7
Gröne, H.-J.8
Krammer Peter, H.9
Gülow, K.10
-
10
-
-
84865294745
-
Metabolic reprogramming and metabolic dependency in T cells
-
Wang R., Green D.R. Metabolic reprogramming and metabolic dependency in T cells. Immunol Rev 2012, 249:14-26.
-
(2012)
Immunol Rev
, vol.249
, pp. 14-26
-
-
Wang, R.1
Green, D.R.2
-
11
-
-
0036069699
-
The CD28 signaling pathway regulates glucose metabolism
-
Frauwirth K.A., Riley J.L., Harris M.H., Parry R.V., Rathmell J.C., Plas D.R., Elstrom R.L., June C.H., Thompson C.B. The CD28 signaling pathway regulates glucose metabolism. Immunity 2002, 16:769-777.
-
(2002)
Immunity
, vol.16
, pp. 769-777
-
-
Frauwirth, K.A.1
Riley, J.L.2
Harris, M.H.3
Parry, R.V.4
Rathmell, J.C.5
Plas, D.R.6
Elstrom, R.L.7
June, C.H.8
Thompson, C.B.9
-
12
-
-
0027474296
-
Metabolic changes in activated T cells: an NMR study of human peripheral blood lymphocytes
-
Bental M., Deutsch C. Metabolic changes in activated T cells: an NMR study of human peripheral blood lymphocytes. Magn Reson Med 1993, 29:317-326.
-
(1993)
Magn Reson Med
, vol.29
, pp. 317-326
-
-
Bental, M.1
Deutsch, C.2
-
13
-
-
79151486083
-
Metabolism, migration and memory in cytotoxic T cells
-
Finlay D., Cantrell D.A. Metabolism, migration and memory in cytotoxic T cells. Nat Rev Immunol 2011, 11:109-117.
-
(2011)
Nat Rev Immunol
, vol.11
, pp. 109-117
-
-
Finlay, D.1
Cantrell, D.A.2
-
14
-
-
44449165597
-
Glucose uptake is limiting in T cell activation and requires CD28-mediated akt-dependent and independent pathways
-
Jacobs S.R., Herman C.E., MacIver N.J., Wofford J.A., Wieman H.L., Hammen J.J., Rathmell J.C. Glucose uptake is limiting in T cell activation and requires CD28-mediated akt-dependent and independent pathways. J Immunol 2008, 180:4476-4486.
-
(2008)
J Immunol
, vol.180
, pp. 4476-4486
-
-
Jacobs, S.R.1
Herman, C.E.2
MacIver, N.J.3
Wofford, J.A.4
Wieman, H.L.5
Hammen, J.J.6
Rathmell, J.C.7
-
15
-
-
0001221508
-
On respiratory impairment in cancer cells
-
Warburg O. On respiratory impairment in cancer cells. Science 1956, 124:269-270.
-
(1956)
Science
, vol.124
, pp. 269-270
-
-
Warburg, O.1
-
16
-
-
84859876379
-
A role for the Warburg effect in preimplantation embryo development: metabolic modification to support rapid cell proliferation
-
Krisher R.L., Prather R.S. A role for the Warburg effect in preimplantation embryo development: metabolic modification to support rapid cell proliferation. Mol Reprod Dev 2012, 79:311-320.
-
(2012)
Mol Reprod Dev
, vol.79
, pp. 311-320
-
-
Krisher, R.L.1
Prather, R.S.2
-
17
-
-
84858709381
-
Glycolysis in preimplantation development is partially controlled by the Warburg effect
-
Redel B.K., Brown A.N., Spate L.D., Whitworth K.M., Green J.A., Prather R.S. Glycolysis in preimplantation development is partially controlled by the Warburg effect. Mol Reprod Dev 2012, 79:262-271.
-
(2012)
Mol Reprod Dev
, vol.79
, pp. 262-271
-
-
Redel, B.K.1
Brown, A.N.2
Spate, L.D.3
Whitworth, K.M.4
Green, J.A.5
Prather, R.S.6
-
18
-
-
0017153683
-
Aerobic glycolysis during lymphocyte proliferation
-
Wang T., Marquardt C., Foker J. Aerobic glycolysis during lymphocyte proliferation. Nature 1976, 261:702-705.
-
(1976)
Nature
, vol.261
, pp. 702-705
-
-
Wang, T.1
Marquardt, C.2
Foker, J.3
-
19
-
-
77954523037
-
Mitochondrial reactive oxygen species control T cell activation by regulating IL-2 and IL-4 expression: mechanism of ciprofloxacin-mediated immunosuppression
-
Kamiński M.M., Sauer S.W., Klemke C.-D., Süss D., Okun J.G., Krammer P.H., Gülow K. Mitochondrial reactive oxygen species control T cell activation by regulating IL-2 and IL-4 expression: mechanism of ciprofloxacin-mediated immunosuppression. J Immunol 2010, 184:4827-4841.
-
(2010)
J Immunol
, vol.184
, pp. 4827-4841
-
-
Kamiński, M.M.1
Sauer, S.W.2
Klemke, C.-D.3
Süss, D.4
Okun, J.G.5
Krammer, P.H.6
Gülow, K.7
-
20
-
-
84874242919
-
Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling
-
Sena Laura A., Li S., Jairaman A., Prakriya M., Ezponda T., Hildeman David A., Wang C.-R., Schumacker Paul T., Licht Jonathan D., Perlman H., et al. Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. Immunity 2013, 38:225-236.
-
(2013)
Immunity
, vol.38
, pp. 225-236
-
-
Sena Laura, A.1
Li, S.2
Jairaman, A.3
Prakriya, M.4
Ezponda, T.5
Hildeman David, A.6
Wang, C.-R.7
Schumacker Paul, T.8
Licht Jonathan, D.9
Perlman, H.10
-
21
-
-
0020617998
-
Glutamine metabolism in lymphocytes of the rat
-
Ardawi M.S., Newsholme E.A. Glutamine metabolism in lymphocytes of the rat. Biochem J 1983, 212:835-842.
-
(1983)
Biochem J
, vol.212
, pp. 835-842
-
-
Ardawi, M.S.1
Newsholme, E.A.2
-
22
-
-
0021977782
-
A quantitative approach to metabolic control
-
Crabtree B., Newsholme E.A. A quantitative approach to metabolic control. Curr Top Cell Regul 1985, 25:21-76.
-
(1985)
Curr Top Cell Regul
, vol.25
, pp. 21-76
-
-
Crabtree, B.1
Newsholme, E.A.2
-
23
-
-
79251500689
-
Manipulating the bioenergetics of alloreactive T cells causes their selective apoptosis and arrests graft-versus-host disease
-
Gatza E., Wahl D.R., Opipari A.W., Sundberg T.B., Reddy P., Liu C., Glick G.D., Ferrara J.L. Manipulating the bioenergetics of alloreactive T cells causes their selective apoptosis and arrests graft-versus-host disease. Sci Transl Med 2011, 3:67ra68.
-
(2011)
Sci Transl Med
, vol.3
-
-
Gatza, E.1
Wahl, D.R.2
Opipari, A.W.3
Sundberg, T.B.4
Reddy, P.5
Liu, C.6
Glick, G.D.7
Ferrara, J.L.8
-
24
-
-
67650096912
-
Enhancing CD8 T-cell memory by modulating fatty acid metabolism
-
Pearce E.L., Walsh M.C., Cejas P.J., Harms G.M., Shen H., Wang L.S., Jones R.G., Choi Y. Enhancing CD8 T-cell memory by modulating fatty acid metabolism. Nature 2009, 460:103-107.
-
(2009)
Nature
, vol.460
, pp. 103-107
-
-
Pearce, E.L.1
Walsh, M.C.2
Cejas, P.J.3
Harms, G.M.4
Shen, H.5
Wang, L.S.6
Jones, R.G.7
Choi, Y.8
-
25
-
-
0030998679
-
Mitogenic stimulation of T cells reveals differing contributions for B7-1 (CD80) and B7-2 (CD86) costimulation
-
Perrin P.J., Davis T.A., Smoot D.S., Abe R., June C.H., Lee K.P. Mitogenic stimulation of T cells reveals differing contributions for B7-1 (CD80) and B7-2 (CD86) costimulation. Immunology 1997, 90:534-542.
-
(1997)
Immunology
, vol.90
, pp. 534-542
-
-
Perrin, P.J.1
Davis, T.A.2
Smoot, D.S.3
Abe, R.4
June, C.H.5
Lee, K.P.6
-
26
-
-
84860015324
-
A proteomic view at T cell costimulation
-
Lichtenfels R., Rappl G., Hombach A.A., Recktenwald C.V., Dressler S.P., Abken H., Seliger B. A proteomic view at T cell costimulation. PLoS ONE 2012, 7:e32994.
-
(2012)
PLoS ONE
, vol.7
-
-
Lichtenfels, R.1
Rappl, G.2
Hombach, A.A.3
Recktenwald, C.V.4
Dressler, S.P.5
Abken, H.6
Seliger, B.7
-
27
-
-
84865291302
-
Distinct metabolic programs in activated T cells: opportunities for selective immunomodulation
-
Wahl D.R., Byersdorfer C.A., Ferrara J.L., Opipari A.W., Glick G.D. Distinct metabolic programs in activated T cells: opportunities for selective immunomodulation. Immunol Rev 2012, 249:104-115.
-
(2012)
Immunol Rev
, vol.249
, pp. 104-115
-
-
Wahl, D.R.1
Byersdorfer, C.A.2
Ferrara, J.L.3
Opipari, A.W.4
Glick, G.D.5
-
28
-
-
0033635249
-
In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability
-
Rathmell J.C., Vander Heiden M.G., Harris M.H., Frauwirth K.A., Thompson C.B. In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. Mol Cell 2000, 6:683-692.
-
(2000)
Mol Cell
, vol.6
, pp. 683-692
-
-
Rathmell, J.C.1
Vander Heiden, M.G.2
Harris, M.H.3
Frauwirth, K.A.4
Thompson, C.B.5
-
29
-
-
0038798020
-
Regulation of the cell-surface expression of an HTLV-I binding protein in human T cells during immune activation
-
Nath M.D., Ruscetti F.W., Petrow-Sadowski C., Jones K.S. Regulation of the cell-surface expression of an HTLV-I binding protein in human T cells during immune activation. Blood 2003, 101:3085-3092.
-
(2003)
Blood
, vol.101
, pp. 3085-3092
-
-
Nath, M.D.1
Ruscetti, F.W.2
Petrow-Sadowski, C.3
Jones, K.S.4
-
30
-
-
0028231378
-
Changes in glucose transport and transporter isoforms during the activation of human peripheral blood lymphocytes by phytohemagglutinin
-
Chakrabarti R., Jung C.Y., Lee T.P., Liu H., Mookerjee B.K. Changes in glucose transport and transporter isoforms during the activation of human peripheral blood lymphocytes by phytohemagglutinin. J Immunol 1994, 152:2660-2668.
-
(1994)
J Immunol
, vol.152
, pp. 2660-2668
-
-
Chakrabarti, R.1
Jung, C.Y.2
Lee, T.P.3
Liu, H.4
Mookerjee, B.K.5
-
31
-
-
0037370905
-
The HTLV receptor is an early T-cell activation marker whose expression requires de novo protein synthesis
-
Manel N., Kinet S., Battini J.L., Kim F.J., Taylor N., Sitbon M. The HTLV receptor is an early T-cell activation marker whose expression requires de novo protein synthesis. Blood 2003, 101:1913-1918.
-
(2003)
Blood
, vol.101
, pp. 1913-1918
-
-
Manel, N.1
Kinet, S.2
Battini, J.L.3
Kim, F.J.4
Taylor, N.5
Sitbon, M.6
-
32
-
-
80054046029
-
Aerobic glycolysis: meeting the metabolic requirements of cell proliferation
-
Lunt S.Y., Vander Heiden M.G. Aerobic glycolysis: meeting the metabolic requirements of cell proliferation. Annu Rev Cell Dev Biol 2011, 27:441-464.
-
(2011)
Annu Rev Cell Dev Biol
, vol.27
, pp. 441-464
-
-
Lunt, S.Y.1
Vander Heiden, M.G.2
-
33
-
-
49649098562
-
Human CD4(+) T cells maintain specific functions even under conditions of extremely restricted ATP production
-
Tripmacher R., Gaber T., Dziurla R., Haupl T., Erekul K., Grutzkau A., Tschirschmann M., Scheffold A., Radbruch A., Burmester G.R., et al. Human CD4(+) T cells maintain specific functions even under conditions of extremely restricted ATP production. Eur J Immunol 2008, 38:1631-1642.
-
(2008)
Eur J Immunol
, vol.38
, pp. 1631-1642
-
-
Tripmacher, R.1
Gaber, T.2
Dziurla, R.3
Haupl, T.4
Erekul, K.5
Grutzkau, A.6
Tschirschmann, M.7
Scheffold, A.8
Radbruch, A.9
Burmester, G.R.10
-
34
-
-
0015951685
-
Combined effects of phytohemagglutinin and staphylococcal enterotoxin B on deoxyribonucleic acid synthesis during blast transformation in human lymphocytes
-
Shambaugh G.E., Blumenschein G.R. Combined effects of phytohemagglutinin and staphylococcal enterotoxin B on deoxyribonucleic acid synthesis during blast transformation in human lymphocytes. Infect Immun 1974, 9:384-390.
-
(1974)
Infect Immun
, vol.9
, pp. 384-390
-
-
Shambaugh, G.E.1
Blumenschein, G.R.2
-
35
-
-
0014271542
-
On the synthesis of RNA in lymphocytes stimulated by phytohemagglutinin. 1. Induction of uridine-kinase and the conversion of uridine to UTP
-
Hausen P., Stein H. On the synthesis of RNA in lymphocytes stimulated by phytohemagglutinin. 1. Induction of uridine-kinase and the conversion of uridine to UTP. Eur J Biochem 1968, 4:401-406.
-
(1968)
Eur J Biochem
, vol.4
, pp. 401-406
-
-
Hausen, P.1
Stein, H.2
-
36
-
-
0018886587
-
Mechanisms of lymphocyte activation: linkage between early protein synthesis and late lymphocyte proliferation
-
Varesio L., Holden H.T. Mechanisms of lymphocyte activation: linkage between early protein synthesis and late lymphocyte proliferation. J Immunol 1980, 124:2288-2294.
-
(1980)
J Immunol
, vol.124
, pp. 2288-2294
-
-
Varesio, L.1
Holden, H.T.2
-
37
-
-
0023948336
-
Effect of phorbol myristate acetate and concanavalin A on the glycolytic enzymes of human peripheral lymphocytes
-
Marjanovic S., Wielburski A., Nelson B.D. Effect of phorbol myristate acetate and concanavalin A on the glycolytic enzymes of human peripheral lymphocytes. Biochim Biophys Acta 1988, 970:1-6.
-
(1988)
Biochim Biophys Acta
, vol.970
, pp. 1-6
-
-
Marjanovic, S.1
Wielburski, A.2
Nelson, B.D.3
-
38
-
-
0033016465
-
CD28 induces cell cycle progression by IL-2-independent down-regulation of p27kip1 expression in human peripheral T lymphocytes
-
Boonen G.J., van Dijk A.M., Verdonck L.F., van Lier R.A., Rijksen G., Medema R.H. CD28 induces cell cycle progression by IL-2-independent down-regulation of p27kip1 expression in human peripheral T lymphocytes. Eur J Immunol 1999, 29:789-798.
-
(1999)
Eur J Immunol
, vol.29
, pp. 789-798
-
-
Boonen, G.J.1
van Dijk, A.M.2
Verdonck, L.F.3
van Lier, R.A.4
Rijksen, G.5
Medema, R.H.6
-
39
-
-
84255199079
-
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
-
Wang R., Dillon Christopher P., Shi Lewis Z., Milasta S., Carter R., Finkelstein D., McCormick Laura L., Fitzgerald P., Chi H., Munger J., et al. The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity 2011, 35:871-882.
-
(2011)
Immunity
, vol.35
, pp. 871-882
-
-
Wang, R.1
Dillon Christopher, P.2
Shi Lewis, Z.3
Milasta, S.4
Carter, R.5
Finkelstein, D.6
McCormick Laura, L.7
Fitzgerald, P.8
Chi, H.9
Munger, J.10
-
40
-
-
0025847242
-
Expression of glycolytic isoenzymes in activated human peripheral lymphocytes: cell cycle analysis using flow cytometry
-
Marjanovic S., Skog S., Heiden T., Tribukait B., Nelson B.D. Expression of glycolytic isoenzymes in activated human peripheral lymphocytes: cell cycle analysis using flow cytometry. Exp Cell Res 1991, 193:425-431.
-
(1991)
Exp Cell Res
, vol.193
, pp. 425-431
-
-
Marjanovic, S.1
Skog, S.2
Heiden, T.3
Tribukait, B.4
Nelson, B.D.5
-
41
-
-
84861005700
-
Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation
-
Telang S., Clem B.F., Klarer A.C., Clem A.L., Trent J.O., Bucala R., Chesney J. Small molecule inhibition of 6-phosphofructo-2-kinase suppresses t cell activation. J Transl Med 2012, 10:95.
-
(2012)
J Transl Med
, vol.10
, pp. 95
-
-
Telang, S.1
Clem, B.F.2
Klarer, A.C.3
Clem, A.L.4
Trent, J.O.5
Bucala, R.6
Chesney, J.7
-
42
-
-
84863982073
-
Expression and role in glycolysis of human ADP-dependent glucokinase
-
Richter S., Richter J.P., Mehta S.Y., Gribble A.M., Sutherland-Smith A.J., Stowell K.M., Print C.G., Ronimus R.S., Wilson W.R. Expression and role in glycolysis of human ADP-dependent glucokinase. Mol Cell Biochem 2012, 364:131-145.
-
(2012)
Mol Cell Biochem
, vol.364
, pp. 131-145
-
-
Richter, S.1
Richter, J.P.2
Mehta, S.Y.3
Gribble, A.M.4
Sutherland-Smith, A.J.5
Stowell, K.M.6
Print, C.G.7
Ronimus, R.S.8
Wilson, W.R.9
-
43
-
-
1242317797
-
Cloning and biochemical characterization of a novel mouse ADP-dependent glucokinase
-
Ronimus R.S., Morgan H.W. Cloning and biochemical characterization of a novel mouse ADP-dependent glucokinase. Biochem Biophys Res Commun 2004, 315:652-658.
-
(2004)
Biochem Biophys Res Commun
, vol.315
, pp. 652-658
-
-
Ronimus, R.S.1
Morgan, H.W.2
-
44
-
-
77956674635
-
Evidence for an alternative glycolytic pathway in rapidly proliferating cells
-
Vander Heiden M.G., Locasale J.W., Swanson K.D., Sharfi H., Heffron G.J., Amador-Noguez D., Christofk H.R., Wagner G., Rabinowitz J.D., Asara J.M., et al. Evidence for an alternative glycolytic pathway in rapidly proliferating cells. Science 2010, 329:1492-1499.
-
(2010)
Science
, vol.329
, pp. 1492-1499
-
-
Vander Heiden, M.G.1
Locasale, J.W.2
Swanson, K.D.3
Sharfi, H.4
Heffron, G.J.5
Amador-Noguez, D.6
Christofk, H.R.7
Wagner, G.8
Rabinowitz, J.D.9
Asara, J.M.10
-
45
-
-
0026000507
-
In vivo regulation of monomer-tetramer conversion of pyruvate kinase subtype M2 by glucose is mediated via fructose 1,6-bisphosphate
-
Ashizawa K., Willingham M.C., Liang C.M., Cheng S.Y. In vivo regulation of monomer-tetramer conversion of pyruvate kinase subtype M2 by glucose is mediated via fructose 1,6-bisphosphate. J Biol Chem 1991, 266:16842-16846.
-
(1991)
J Biol Chem
, vol.266
, pp. 16842-16846
-
-
Ashizawa, K.1
Willingham, M.C.2
Liang, C.M.3
Cheng, S.Y.4
-
46
-
-
34548014737
-
Revving the engine: signal transduction fuels T cell activation
-
Jones R.G., Thompson C.B. Revving the engine: signal transduction fuels T cell activation. Immunity 2007, 27:173-178.
-
(2007)
Immunity
, vol.27
, pp. 173-178
-
-
Jones, R.G.1
Thompson, C.B.2
-
47
-
-
0027418622
-
Transport of lactate and other monocarboxylates across mammalian plasma membranes
-
Poole R.C., Halestrap A.P. Transport of lactate and other monocarboxylates across mammalian plasma membranes. Am J Physiol 1993, 264:C761-C782.
-
(1993)
Am J Physiol
, vol.264
-
-
Poole, R.C.1
Halestrap, A.P.2
-
48
-
-
0023874138
-
Metabolism of pyruvate by isolated rat mesenteric lymphocytes, lymphocyte mitochondria and isolated mouse macrophages
-
Curi R., Newsholme P., Newsholme E.A. Metabolism of pyruvate by isolated rat mesenteric lymphocytes, lymphocyte mitochondria and isolated mouse macrophages. Biochem J 1988, 250:383-388.
-
(1988)
Biochem J
, vol.250
, pp. 383-388
-
-
Curi, R.1
Newsholme, P.2
Newsholme, E.A.3
-
49
-
-
84856687289
-
The role of low-level lactate production in airway inflammation in asthma
-
Ostroukhova M., Goplen N., Karim M.Z., Michalec L., Guo L., Liang Q., Alam R. The role of low-level lactate production in airway inflammation in asthma. Am J Physiol Lung Cell Mol Physiol 2012, 302:L300-L307.
-
(2012)
Am J Physiol Lung Cell Mol Physiol
, vol.302
-
-
Ostroukhova, M.1
Goplen, N.2
Karim, M.Z.3
Michalec, L.4
Guo, L.5
Liang, Q.6
Alam, R.7
-
50
-
-
0014967402
-
Changes in the carbohydrate metabolism of mitogenically stimulated human peripheral lymphocytes. I. Stimulation by phytohaemagglutinin
-
Roos D., Loos J.A. Changes in the carbohydrate metabolism of mitogenically stimulated human peripheral lymphocytes. I. Stimulation by phytohaemagglutinin. Biochim Biophys Acta 1970, 222:565-582.
-
(1970)
Biochim Biophys Acta
, vol.222
, pp. 565-582
-
-
Roos, D.1
Loos, J.A.2
-
51
-
-
57349094260
-
Glycerol-3-phosphate acyltransferase-1 regulates murine T-lymphocyte proliferation and cytokine production
-
Collison L.W., Murphy E.J., Jolly C.A. Glycerol-3-phosphate acyltransferase-1 regulates murine T-lymphocyte proliferation and cytokine production. Am J Physiol Cell Physiol 2008, 295:C1543-C1549.
-
(2008)
Am J Physiol Cell Physiol
, vol.295
-
-
Collison, L.W.1
Murphy, E.J.2
Jolly, C.A.3
-
52
-
-
0016338510
-
The effect of cyclic nucleotides on purine biosynthesis and the induction of PRPP synthetase during lymphocyte activation
-
Chambers D.A., Martin D.W., Weinstein Y. The effect of cyclic nucleotides on purine biosynthesis and the induction of PRPP synthetase during lymphocyte activation. Cell 1974, 3:375-380.
-
(1974)
Cell
, vol.3
, pp. 375-380
-
-
Chambers, D.A.1
Martin, D.W.2
Weinstein, Y.3
-
53
-
-
0029585361
-
Importance of ribonucleotide availability to proliferating T-lymphocytes from healthy humans. Disproportionate expansion of pyrimidine pools and contrasting effects of de novo synthesis inhibitors
-
Fairbanks L.D., Bofill M., Ruckemann K., Simmonds H.A. Importance of ribonucleotide availability to proliferating T-lymphocytes from healthy humans. Disproportionate expansion of pyrimidine pools and contrasting effects of de novo synthesis inhibitors. J Biol Chem 1995, 270:29682-29689.
-
(1995)
J Biol Chem
, vol.270
, pp. 29682-29689
-
-
Fairbanks, L.D.1
Bofill, M.2
Ruckemann, K.3
Simmonds, H.A.4
-
54
-
-
69949124867
-
Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells
-
Feron O. Pyruvate into lactate and back: from the Warburg effect to symbiotic energy fuel exchange in cancer cells. Radiother Oncol 2009, 92:329-333.
-
(2009)
Radiother Oncol
, vol.92
, pp. 329-333
-
-
Feron, O.1
-
55
-
-
0035371184
-
Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple
-
Schafer F.Q., Buettner G.R. Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic Biol Med 2001, 30:1191-1212.
-
(2001)
Free Radic Biol Med
, vol.30
, pp. 1191-1212
-
-
Schafer, F.Q.1
Buettner, G.R.2
-
56
-
-
0017851009
-
Determination of pyruvate oxidation rate and citric acid cycle activity in intact human leukocytes and fibroblasts
-
Willems H.L., de Kort T.F., Trijbels F.J., Monnens L.A., Veerkamp J.H. Determination of pyruvate oxidation rate and citric acid cycle activity in intact human leukocytes and fibroblasts. Clin Chem 1978, 24:200-203.
-
(1978)
Clin Chem
, vol.24
, pp. 200-203
-
-
Willems, H.L.1
de Kort, T.F.2
Trijbels, F.J.3
Monnens, L.A.4
Veerkamp, J.H.5
-
57
-
-
0027142559
-
Structure, function and regulation of the tricarboxylate transport protein from rat liver mitochondria
-
Kaplan R.S., Mayor J.A. Structure, function and regulation of the tricarboxylate transport protein from rat liver mitochondria. J Bioenerg Biomembr 1993, 25:503-514.
-
(1993)
J Bioenerg Biomembr
, vol.25
, pp. 503-514
-
-
Kaplan, R.S.1
Mayor, J.A.2
-
58
-
-
0015218580
-
Factors affecting the kinetics and equilibrium of exchange reactions of the citrate-transporting system of rat liver mitochondria
-
Robinson B.H., Williams G.R., Halperin M.L., Leznoff C.C. Factors affecting the kinetics and equilibrium of exchange reactions of the citrate-transporting system of rat liver mitochondria. J Biol Chem 1971, 246:5280-5286.
-
(1971)
J Biol Chem
, vol.246
, pp. 5280-5286
-
-
Robinson, B.H.1
Williams, G.R.2
Halperin, M.L.3
Leznoff, C.C.4
-
59
-
-
0025077753
-
NADP+ reduction by human lymphocytes
-
Klein A., Chan A.W., Caplan B.U., Malin A. NADP+ reduction by human lymphocytes. Clin Exp Immunol 1990, 82:170-173.
-
(1990)
Clin Exp Immunol
, vol.82
, pp. 170-173
-
-
Klein, A.1
Chan, A.W.2
Caplan, B.U.3
Malin, A.4
-
60
-
-
0012001813
-
The supply of precursors for the synthesis of fatty acids
-
Spencer A.F., Lowenstein J.M. The supply of precursors for the synthesis of fatty acids. J Biol Chem 1962, 237:3640-3648.
-
(1962)
J Biol Chem
, vol.237
, pp. 3640-3648
-
-
Spencer, A.F.1
Lowenstein, J.M.2
-
61
-
-
0025916883
-
Interrelationships between mevalonate metabolism and the mitogenic signaling pathway in T lymphocyte proliferation
-
Chakrabarti R., Engleman E.G. Interrelationships between mevalonate metabolism and the mitogenic signaling pathway in T lymphocyte proliferation. J Biol Chem 1991, 266:12216-12222.
-
(1991)
J Biol Chem
, vol.266
, pp. 12216-12222
-
-
Chakrabarti, R.1
Engleman, E.G.2
-
62
-
-
0037038402
-
The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease
-
Youssef S., Stuve O., Patarroyo J.C., Ruiz P.J., Radosevich J.L., Hur E.M., Bravo M., Mitchell D.J., Sobel R.A., Steinman L., et al. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias and reverses paralysis in central nervous system autoimmune disease. Nature 2002, 420:78-84.
-
(2002)
Nature
, vol.420
, pp. 78-84
-
-
Youssef, S.1
Stuve, O.2
Patarroyo, J.C.3
Ruiz, P.J.4
Radosevich, J.L.5
Hur, E.M.6
Bravo, M.7
Mitchell, D.J.8
Sobel, R.A.9
Steinman, L.10
-
63
-
-
77955483125
-
Activation of a metabolic gene regulatory network downstream of mTOR complex 1
-
Duvel K., Yecies J.L., Menon S., Raman P., Lipovsky A.I., Souza A.L., Triantafellow E., Ma Q., Gorski R., Cleaver S., et al. Activation of a metabolic gene regulatory network downstream of mTOR complex 1. Mol Cell 2010, 39:171-183.
-
(2010)
Mol Cell
, vol.39
, pp. 171-183
-
-
Duvel, K.1
Yecies, J.L.2
Menon, S.3
Raman, P.4
Lipovsky, A.I.5
Souza, A.L.6
Triantafellow, E.7
Ma, Q.8
Gorski, R.9
Cleaver, S.10
-
64
-
-
46149098344
-
LXR signaling couples sterol metabolism to proliferation in the acquired immune response
-
Bensinger S.J., Bradley M.N., Joseph S.B., Zelcer N., Janssen E.M., Hausner M.A., Shih R., Parks J.S., Edwards P.A., Jamieson B.D., et al. LXR signaling couples sterol metabolism to proliferation in the acquired immune response. Cell 2008, 134:97-111.
-
(2008)
Cell
, vol.134
, pp. 97-111
-
-
Bensinger, S.J.1
Bradley, M.N.2
Joseph, S.B.3
Zelcer, N.4
Janssen, E.M.5
Hausner, M.A.6
Shih, R.7
Parks, J.S.8
Edwards, P.A.9
Jamieson, B.D.10
-
65
-
-
84856183120
-
Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development
-
van der Windt Gerritje J.W., Everts B., Chang C.-H., Curtis Jonathan D., Freitas Tori C., Amiel E., Pearce Edward J., Pearce Erika L. Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development. Immunity 2012, 36:68-78.
-
(2012)
Immunity
, vol.36
, pp. 68-78
-
-
van der Windt Gerritje, J.W.1
Everts, B.2
Chang, C.-H.3
Curtis Jonathan, D.4
Freitas Tori, C.5
Amiel, E.6
Pearce Edward, J.7
Pearce Erika, L.8
-
66
-
-
15244348270
-
Lipid rafts and their roles in T-cell activation
-
Hořejší V. Lipid rafts and their roles in T-cell activation. Micr Infect 2005, 7:310-316.
-
(2005)
Micr Infect
, vol.7
, pp. 310-316
-
-
Hořejší, V.1
-
67
-
-
84857125059
-
CD4 and CD8 T cells require different membrane gangliosides for activation
-
Nagafuku M., Okuyama K., Onimaru Y., Suzuki A., Odagiri Y., Yamashita T., Iwasaki K., Fujiwara M., Takayanagi M., Ohno I., et al. CD4 and CD8 T cells require different membrane gangliosides for activation. Proc Natl Acad Sci U S A 2012, 109:E336-E342.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
-
-
Nagafuku, M.1
Okuyama, K.2
Onimaru, Y.3
Suzuki, A.4
Odagiri, Y.5
Yamashita, T.6
Iwasaki, K.7
Fujiwara, M.8
Takayanagi, M.9
Ohno, I.10
-
68
-
-
0030949124
-
Functional rafts in cell membranes
-
Simons K., Ikonen E. Functional rafts in cell membranes. Nature 1997, 387:569-572.
-
(1997)
Nature
, vol.387
, pp. 569-572
-
-
Simons, K.1
Ikonen, E.2
-
69
-
-
0037069384
-
Human CD8+ T cells do not require the polarization of lipid rafts for activation and proliferation
-
Kovacs B., Maus M.V., Riley J.L., Derimanov G.S., Koretzky G.A., June C.H., Finkel T.H. Human CD8+ T cells do not require the polarization of lipid rafts for activation and proliferation. Proc Natl Acad Sci U S A 2002, 99:15006-15011.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 15006-15011
-
-
Kovacs, B.1
Maus, M.V.2
Riley, J.L.3
Derimanov, G.S.4
Koretzky, G.A.5
June, C.H.6
Finkel, T.H.7
-
70
-
-
0027770941
-
Exogenous glutamine requirement is confined to late events of T cell activation
-
Horig H., Spagnoli G.C., Filgueira L., Babst R., Gallati H., Harder F., Juretic A., Heberer M. Exogenous glutamine requirement is confined to late events of T cell activation. J Cell Biochem 1993, 53:343-351.
-
(1993)
J Cell Biochem
, vol.53
, pp. 343-351
-
-
Horig, H.1
Spagnoli, G.C.2
Filgueira, L.3
Babst, R.4
Gallati, H.5
Harder, F.6
Juretic, A.7
Heberer, M.8
-
71
-
-
77955475969
-
Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation
-
Carr E.L., Kelman A., Wu G.S., Gopaul R., Senkevitch E., Aghvanyan A., Turay A.M., Frauwirth K.A. Glutamine uptake and metabolism are coordinately regulated by ERK/MAPK during T lymphocyte activation. J Immunol 2010, 185:1037-1044.
-
(2010)
J Immunol
, vol.185
, pp. 1037-1044
-
-
Carr, E.L.1
Kelman, A.2
Wu, G.S.3
Gopaul, R.4
Senkevitch, E.5
Aghvanyan, A.6
Turay, A.M.7
Frauwirth, K.A.8
-
72
-
-
75149148563
-
Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer
-
DeBerardinis R.J., Cheng T. Q's next: the diverse functions of glutamine in metabolism, cell biology and cancer. Oncogene 2010, 29:313-324.
-
(2010)
Oncogene
, vol.29
, pp. 313-324
-
-
DeBerardinis, R.J.1
Cheng, T.2
-
73
-
-
4043142925
-
Molecular screening of the human glutamine-fructose-6-phosphate amidotransferase 1 (GFPT1) gene and association studies with diabetes and diabetic nephropathy
-
Elbein S.C., Zheng H., Jia Y., Chu W., Cooper J.J., Hale T., Zhang Z. Molecular screening of the human glutamine-fructose-6-phosphate amidotransferase 1 (GFPT1) gene and association studies with diabetes and diabetic nephropathy. Mol Genet Metab 2004, 82:321-328.
-
(2004)
Mol Genet Metab
, vol.82
, pp. 321-328
-
-
Elbein, S.C.1
Zheng, H.2
Jia, Y.3
Chu, W.4
Cooper, J.J.5
Hale, T.6
Zhang, Z.7
-
74
-
-
33748127113
-
Suppression of T-cell functions by human granulocyte arginase
-
Munder M., Schneider H., Luckner C., Giese T., Langhans C.D., Fuentes J.M., Kropf P., Mueller I., Kolb A., Modolell M., et al. Suppression of T-cell functions by human granulocyte arginase. Blood 2006, 108:1627-1634.
-
(2006)
Blood
, vol.108
, pp. 1627-1634
-
-
Munder, M.1
Schneider, H.2
Luckner, C.3
Giese, T.4
Langhans, C.D.5
Fuentes, J.M.6
Kropf, P.7
Mueller, I.8
Kolb, A.9
Modolell, M.10
-
75
-
-
0032102990
-
Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/arginase balance: competitive regulation by CD4+ T cells correlates with Th1/Th2 phenotype
-
Munder M., Eichmann K., Modolell M. Alternative metabolic states in murine macrophages reflected by the nitric oxide synthase/arginase balance: competitive regulation by CD4+ T cells correlates with Th1/Th2 phenotype. J Immunol 1998, 160:5347-5354.
-
(1998)
J Immunol
, vol.160
, pp. 5347-5354
-
-
Munder, M.1
Eichmann, K.2
Modolell, M.3
-
76
-
-
77951737056
-
Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction
-
Matteoli G., Mazzini E., Iliev I.D., Mileti E., Fallarino F., Puccetti P., Chieppa M., Rescigno M. Gut CD103+ dendritic cells express indoleamine 2,3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction. Gut 2010, 59:595-604.
-
(2010)
Gut
, vol.59
, pp. 595-604
-
-
Matteoli, G.1
Mazzini, E.2
Iliev, I.D.3
Mileti, E.4
Fallarino, F.5
Puccetti, P.6
Chieppa, M.7
Rescigno, M.8
-
77
-
-
63849112500
-
The role of indoleamine 2,3-dioxygenase in the induction of immune tolerance: focus on hematology
-
Curti A., Trabanelli S., Salvestrini V., Baccarani M., Lemoli R.M. The role of indoleamine 2,3-dioxygenase in the induction of immune tolerance: focus on hematology. Blood 2009, 113:2394-2401.
-
(2009)
Blood
, vol.113
, pp. 2394-2401
-
-
Curti, A.1
Trabanelli, S.2
Salvestrini, V.3
Baccarani, M.4
Lemoli, R.M.5
-
78
-
-
0037090313
-
Cells expressing indoleamine 2,3-dioxygenase inhibit T cell responses
-
Mellor A.L., Keskin D.B., Johnson T., Chandler P., Munn D.H. Cells expressing indoleamine 2,3-dioxygenase inhibit T cell responses. J Immunol 2002, 168:3771-3776.
-
(2002)
J Immunol
, vol.168
, pp. 3771-3776
-
-
Mellor, A.L.1
Keskin, D.B.2
Johnson, T.3
Chandler, P.4
Munn, D.H.5
-
79
-
-
0041845173
-
L-Arginine consumption by macrophages modulates the expression of CD3 zeta chain in T lymphocytes
-
Rodriguez P.C., Zea A.H., DeSalvo J., Culotta K.S., Zabaleta J., Quiceno D.G., Ochoa J.B., Ochoa A.C. l-Arginine consumption by macrophages modulates the expression of CD3 zeta chain in T lymphocytes. J Immunol 2003, 171:1232-1239.
-
(2003)
J Immunol
, vol.171
, pp. 1232-1239
-
-
Rodriguez, P.C.1
Zea, A.H.2
DeSalvo, J.3
Culotta, K.S.4
Zabaleta, J.5
Quiceno, D.G.6
Ochoa, J.B.7
Ochoa, A.C.8
-
80
-
-
84861305124
-
Regulation of polyamine metabolism by translational control
-
Perez-Leal O., Merali S. Regulation of polyamine metabolism by translational control. Amino Acids 2012, 42:611-617.
-
(2012)
Amino Acids
, vol.42
, pp. 611-617
-
-
Perez-Leal, O.1
Merali, S.2
-
81
-
-
0016792406
-
Increased cellular levels of spermidine or spermine are required for optimal DNA synthesis in lymphocytes activated by concanavalin A
-
Fillingame R.H., Jorstad C.M., Morris D.R. Increased cellular levels of spermidine or spermine are required for optimal DNA synthesis in lymphocytes activated by concanavalin A. Proc Natl Acad Sci U S A 1975, 72:4042-4045.
-
(1975)
Proc Natl Acad Sci U S A
, vol.72
, pp. 4042-4045
-
-
Fillingame, R.H.1
Jorstad, C.M.2
Morris, D.R.3
-
82
-
-
0015851457
-
Polyamine accumulation during lymphocyte transformation and its relation to the synthesis, processing, and accumulation of ribonucleic acid
-
Fillingame R.H., Morris D.R. Polyamine accumulation during lymphocyte transformation and its relation to the synthesis, processing, and accumulation of ribonucleic acid. Biochemistry 1973, 12:4479-4487.
-
(1973)
Biochemistry
, vol.12
, pp. 4479-4487
-
-
Fillingame, R.H.1
Morris, D.R.2
-
83
-
-
0026714435
-
Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination
-
Murakami Y., Matsufuji S., Kameji T., Hayashi S., Igarashi K., Tamura T., Tanaka K., Ichihara A. Ornithine decarboxylase is degraded by the 26S proteasome without ubiquitination. Nature 1992, 360:597-599.
-
(1992)
Nature
, vol.360
, pp. 597-599
-
-
Murakami, Y.1
Matsufuji, S.2
Kameji, T.3
Hayashi, S.4
Igarashi, K.5
Tamura, T.6
Tanaka, K.7
Ichihara, A.8
-
84
-
-
34547671110
-
Ubiquitin dependent and independent protein degradation in the regulation of cellular polyamines
-
Kahana C. Ubiquitin dependent and independent protein degradation in the regulation of cellular polyamines. Amino Acids 2007, 33:225-230.
-
(2007)
Amino Acids
, vol.33
, pp. 225-230
-
-
Kahana, C.1
-
85
-
-
0022178318
-
Polyamine depletion results in impairment of polyribosome formation and protein synthesis before onset of DNA synthesis in mitogen-activated human lymphocytes
-
Holtta E., Hovi T. Polyamine depletion results in impairment of polyribosome formation and protein synthesis before onset of DNA synthesis in mitogen-activated human lymphocytes. Eur J Biochem 1985, 152:229-237.
-
(1985)
Eur J Biochem
, vol.152
, pp. 229-237
-
-
Holtta, E.1
Hovi, T.2
-
86
-
-
0031726059
-
Differential effect on polyamine metabolism in mitogen- and superantigen-activated human T-cells
-
Langkamp-Henken B., Johnson L.R., Viar M.J., Geller A.M., Kotb M. Differential effect on polyamine metabolism in mitogen- and superantigen-activated human T-cells. Biochim Biophys Acta 1998, 1425:337-347.
-
(1998)
Biochim Biophys Acta
, vol.1425
, pp. 337-347
-
-
Langkamp-Henken, B.1
Johnson, L.R.2
Viar, M.J.3
Geller, A.M.4
Kotb, M.5
-
87
-
-
0242691701
-
Defining the molecular requirements for the selective delivery of polyamine conjugates into cells containing active polyamine transporters
-
Wang C., Delcros J.G., Cannon L., Konate F., Carias H., Biggerstaff J., Gardner R.A., Phanstiel O. Defining the molecular requirements for the selective delivery of polyamine conjugates into cells containing active polyamine transporters. J Med Chem 2003, 46:5129-5138.
-
(2003)
J Med Chem
, vol.46
, pp. 5129-5138
-
-
Wang, C.1
Delcros, J.G.2
Cannon, L.3
Konate, F.4
Carias, H.5
Biggerstaff, J.6
Gardner, R.A.7
Phanstiel, O.8
-
88
-
-
0037033433
-
Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen-activated protein kinase activation and fas ligand expression
-
Devadas S., Zaritskaya L., Rhee S.G., Oberley L., Williams M.S. Discrete generation of superoxide and hydrogen peroxide by T cell receptor stimulation: selective regulation of mitogen-activated protein kinase activation and fas ligand expression. J Exp Med 2002, 195:59-70.
-
(2002)
J Exp Med
, vol.195
, pp. 59-70
-
-
Devadas, S.1
Zaritskaya, L.2
Rhee, S.G.3
Oberley, L.4
Williams, M.S.5
-
89
-
-
0034643340
-
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage
-
Nishikawa T., Edelstein D., Du X.L., Yamagishi S., Matsumura T., Kaneda Y., Yorek M.A., Beebe D., Oates P.J., Hammes H.P., et al. Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damage. Nature 2000, 404:787-790.
-
(2000)
Nature
, vol.404
, pp. 787-790
-
-
Nishikawa, T.1
Edelstein, D.2
Du, X.L.3
Yamagishi, S.4
Matsumura, T.5
Kaneda, Y.6
Yorek, M.A.7
Beebe, D.8
Oates, P.J.9
Hammes, H.P.10
-
90
-
-
0036086130
-
Free radicals in the physiological control of cell function
-
Droge W. Free radicals in the physiological control of cell function. Physiol Rev 2002, 82:47-95.
-
(2002)
Physiol Rev
, vol.82
, pp. 47-95
-
-
Droge, W.1
-
91
-
-
0142150051
-
Mitochondrial formation of reactive oxygen species
-
Turrens J.F. Mitochondrial formation of reactive oxygen species. J Physiol 2003, 552:335-344.
-
(2003)
J Physiol
, vol.552
, pp. 335-344
-
-
Turrens, J.F.1
-
92
-
-
0037458619
-
Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol
-
Han D., Antunes F., Canali R., Rettori D., Cadenas E. Voltage-dependent anion channels control the release of the superoxide anion from mitochondria to cytosol. J Biol Chem 2003, 278:5557-5563.
-
(2003)
J Biol Chem
, vol.278
, pp. 5557-5563
-
-
Han, D.1
Antunes, F.2
Canali, R.3
Rettori, D.4
Cadenas, E.5
-
93
-
-
0029164695
-
IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase
-
Los M., Schenk H., Hexel K., Baeuerle P.A., Droge W., Schulze-Osthoff K. IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase. EMBO J 1995, 14:3731-3740.
-
(1995)
EMBO J
, vol.14
, pp. 3731-3740
-
-
Los, M.1
Schenk, H.2
Hexel, K.3
Baeuerle, P.A.4
Droge, W.5
Schulze-Osthoff, K.6
-
94
-
-
4444221709
-
T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation
-
Jackson S.H., Devadas S., Kwon J., Pinto L.A., Williams M.S. T cells express a phagocyte-type NADPH oxidase that is activated after T cell receptor stimulation. Nat Immunol 2004, 5:818-827.
-
(2004)
Nat Immunol
, vol.5
, pp. 818-827
-
-
Jackson, S.H.1
Devadas, S.2
Kwon, J.3
Pinto, L.A.4
Williams, M.S.5
-
95
-
-
17044422629
-
Glucose availability regulates IFN-gamma production and p70S6 kinase activation in CD8+ effector T cells
-
Cham C.M., Gajewski T.F. Glucose availability regulates IFN-gamma production and p70S6 kinase activation in CD8+ effector T cells. J Immunol 2005, 174:4670-4677.
-
(2005)
J Immunol
, vol.174
, pp. 4670-4677
-
-
Cham, C.M.1
Gajewski, T.F.2
-
96
-
-
55249114228
-
Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells
-
Cham C.M., Driessens G., O'Keefe J.P., Gajewski T.F. Glucose deprivation inhibits multiple key gene expression events and effector functions in CD8+ T cells. Eur J Immunol 2008, 38:2438-2450.
-
(2008)
Eur J Immunol
, vol.38
, pp. 2438-2450
-
-
Cham, C.M.1
Driessens, G.2
O'Keefe, J.P.3
Gajewski, T.F.4
-
97
-
-
74649085700
-
The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin
-
Rao R.R., Li Q., Odunsi K., Shrikant P.A. The mTOR kinase determines effector versus memory CD8+ T cell fate by regulating the expression of transcription factors T-bet and Eomesodermin. Immunity 2010, 32:67-78.
-
(2010)
Immunity
, vol.32
, pp. 67-78
-
-
Rao, R.R.1
Li, Q.2
Odunsi, K.3
Shrikant, P.A.4
-
98
-
-
67650074206
-
MTOR regulates memory CD8 T-cell differentiation
-
Araki K., Turner A.P., Shaffer V.O., Gangappa S., Keller S.A., Bachmann M.F., Larsen C.P., Ahmed R. mTOR regulates memory CD8 T-cell differentiation. Nature 2009, 460:108-112.
-
(2009)
Nature
, vol.460
, pp. 108-112
-
-
Araki, K.1
Turner, A.P.2
Shaffer, V.O.3
Gangappa, S.4
Keller, S.A.5
Bachmann, M.F.6
Larsen, C.P.7
Ahmed, R.8
-
99
-
-
77952467331
-
Heterogeneity of human effector CD4+ T cells
-
Annunziato F., Romagnani S. Heterogeneity of human effector CD4+ T cells. Arthritis Res Ther 2009, 11:257.
-
(2009)
Arthritis Res Ther
, vol.11
, pp. 257
-
-
Annunziato, F.1
Romagnani, S.2
-
100
-
-
43949105866
-
Regulatory T cells and immune tolerance
-
Sakaguchi S., Yamaguchi T., Nomura T., Ono M. Regulatory T cells and immune tolerance. Cell 2008, 133:775-787.
-
(2008)
Cell
, vol.133
, pp. 775-787
-
-
Sakaguchi, S.1
Yamaguchi, T.2
Nomura, T.3
Ono, M.4
-
101
-
-
79953172571
-
Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets
-
Michalek R.D., Gerriets V.A., Jacobs S.R., Macintyre A.N., MacIver N.J., Mason E.F., Sullivan S.A., Nichols A.G., Rathmell J.C. Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. J Immunol 2011, 186:3299-3303.
-
(2011)
J Immunol
, vol.186
, pp. 3299-3303
-
-
Michalek, R.D.1
Gerriets, V.A.2
Jacobs, S.R.3
Macintyre, A.N.4
MacIver, N.J.5
Mason, E.F.6
Sullivan, S.A.7
Nichols, A.G.8
Rathmell, J.C.9
-
102
-
-
0037423752
-
Inhibition of amino acid-mTOR signaling by a leucine derivative induces G1 arrest in Jurkat cells
-
Hidayat S., Yoshino K-i, Tokunaga C., Hara K., Matsuo M., Yonezawa K. Inhibition of amino acid-mTOR signaling by a leucine derivative induces G1 arrest in Jurkat cells. Biochem Biophys Res Commun 2003, 301:417-423.
-
(2003)
Biochem Biophys Res Commun
, vol.301
, pp. 417-423
-
-
Hidayat, S.1
Yoshino, K.-I.2
Tokunaga, C.3
Hara, K.4
Matsuo, M.5
Yonezawa, K.6
-
103
-
-
77952280516
-
Anergic T cells are metabolically anergic
-
Zheng Y., Delgoffe G.M., Meyer C.F., Chan W., Powell J.D. Anergic T cells are metabolically anergic. J Immunol 2009, 183:6095-6101.
-
(2009)
J Immunol
, vol.183
, pp. 6095-6101
-
-
Zheng, Y.1
Delgoffe, G.M.2
Meyer, C.F.3
Chan, W.4
Powell, J.D.5
-
104
-
-
84876514626
-
Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation
-
Sinclair L.V., Rolf J., Emslie E., Shi Y.-B., Taylor P.M., Cantrell D.A. Control of amino-acid transport by antigen receptors coordinates the metabolic reprogramming essential for T cell differentiation. Nat Immunol 2013, 14:500-508.
-
(2013)
Nat Immunol
, vol.14
, pp. 500-508
-
-
Sinclair, L.V.1
Rolf, J.2
Emslie, E.3
Shi, Y.-B.4
Taylor, P.M.5
Cantrell, D.A.6
-
105
-
-
1342281232
-
CATs and HATs: the SLC7 family of amino acid transporters
-
Verrey F., Closs E.I., Wagner C.A., Palacin M., Endou H., Kanai Y. CATs and HATs: the SLC7 family of amino acid transporters. Pflugers Arch 2004, 447:532-542.
-
(2004)
Pflugers Arch
, vol.447
, pp. 532-542
-
-
Verrey, F.1
Closs, E.I.2
Wagner, C.A.3
Palacin, M.4
Endou, H.5
Kanai, Y.6
-
106
-
-
36749047009
-
Amino acids and mTOR signalling in anabolic function
-
Proud C.G. Amino acids and mTOR signalling in anabolic function. Biochem Soc Trans 2007, 35:1187-1190.
-
(2007)
Biochem Soc Trans
, vol.35
, pp. 1187-1190
-
-
Proud, C.G.1
-
107
-
-
45849105156
-
The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1
-
Sancak Y., Peterson T.R., Shaul Y.D., Lindquist R.A., Thoreen C.C., Bar-Peled L., Sabatini D.M. The Rag GTPases bind raptor and mediate amino acid signaling to mTORC1. Science 2008, 320:1496-1501.
-
(2008)
Science
, vol.320
, pp. 1496-1501
-
-
Sancak, Y.1
Peterson, T.R.2
Shaul, Y.D.3
Lindquist, R.A.4
Thoreen, C.C.5
Bar-Peled, L.6
Sabatini, D.M.7
-
108
-
-
84866431363
-
Ragulator is a GEF for the Rag GTPases that signal amino acid levels tomTORC1
-
Bar-Peled L., Schweitzer L.D., Zoncu R., Sabatini D.M. Ragulator is a GEF for the Rag GTPases that signal amino acid levels tomTORC1. Cell 2012, 150:1196-1208.
-
(2012)
Cell
, vol.150
, pp. 1196-1208
-
-
Bar-Peled, L.1
Schweitzer, L.D.2
Zoncu, R.3
Sabatini, D.M.4
-
109
-
-
79952985551
-
The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2
-
Delgoffe G.M., Pollizzi K.N., Waickman A.T., Heikamp E., Meyers D.J., Horton M.R., Xiao B., Worley P.F., Powell J.D. The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2. Nat Immunol 2011, 12:295-303.
-
(2011)
Nat Immunol
, vol.12
, pp. 295-303
-
-
Delgoffe, G.M.1
Pollizzi, K.N.2
Waickman, A.T.3
Heikamp, E.4
Meyers, D.J.5
Horton, M.R.6
Xiao, B.7
Worley, P.F.8
Powell, J.D.9
-
110
-
-
70350418625
-
MTOR signaling at a glance
-
Laplante M., Sabatini D.M. mTOR signaling at a glance. J Cell Sci 2009, 122:3589-3594.
-
(2009)
J Cell Sci
, vol.122
, pp. 3589-3594
-
-
Laplante, M.1
Sabatini, D.M.2
-
111
-
-
35748956420
-
Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells
-
Kopf H., de la Rosa G.M., Howard O.M., Chen X. Rapamycin inhibits differentiation of Th17 cells and promotes generation of FoxP3+ T regulatory cells. Int Immunopharmacol 2007, 7:1819-1824.
-
(2007)
Int Immunopharmacol
, vol.7
, pp. 1819-1824
-
-
Kopf, H.1
de la Rosa, G.M.2
Howard, O.M.3
Chen, X.4
-
112
-
-
77957054466
-
The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism
-
Powell J.D., Delgoffe G.M. The mammalian target of rapamycin: linking T cell differentiation, function, and metabolism. Immunity 2010, 33:301-311.
-
(2010)
Immunity
, vol.33
, pp. 301-311
-
-
Powell, J.D.1
Delgoffe, G.M.2
-
113
-
-
84880352272
-
Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers
-
Pourdehnad M., Truitt M.L., Siddiqi I.N., Ducker G.S., Shokat K.M., Ruggero D. Myc and mTOR converge on a common node in protein synthesis control that confers synthetic lethality in Myc-driven cancers. Proc Natl Acad Sci U S A 2013, 110:11988-11993.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 11988-11993
-
-
Pourdehnad, M.1
Truitt, M.L.2
Siddiqi, I.N.3
Ducker, G.S.4
Shokat, K.M.5
Ruggero, D.6
-
114
-
-
33644614520
-
HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia
-
Kim J.W., Tchernyshyov I., Semenza G.L., Dang C.V. HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. Cell Metab 2006, 3:177-185.
-
(2006)
Cell Metab
, vol.3
, pp. 177-185
-
-
Kim, J.W.1
Tchernyshyov, I.2
Semenza, G.L.3
Dang, C.V.4
-
115
-
-
79960369458
-
HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
-
Shi L.Z., Wang R., Huang G., Vogel P., Neale G., Green D.R., Chi H. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J Exp Med 2011, 208:1367-1376.
-
(2011)
J Exp Med
, vol.208
, pp. 1367-1376
-
-
Shi, L.Z.1
Wang, R.2
Huang, G.3
Vogel, P.4
Neale, G.5
Green, D.R.6
Chi, H.7
-
116
-
-
84866562625
-
Metabolic checkpoints in activated T cells
-
Wang R., Green D.R. Metabolic checkpoints in activated T cells. Nat Immunol 2012, 13:907-915.
-
(2012)
Nat Immunol
, vol.13
, pp. 907-915
-
-
Wang, R.1
Green, D.R.2
-
117
-
-
0346685840
-
De novo emergence of growth factor receptors in activated human CD4+ and CD8+ T lymphocytes
-
Stentz F.B., Kitabchi A.E. De novo emergence of growth factor receptors in activated human CD4+ and CD8+ T lymphocytes. Metabolism 2004, 53:117-122.
-
(2004)
Metabolism
, vol.53
, pp. 117-122
-
-
Stentz, F.B.1
Kitabchi, A.E.2
-
119
-
-
33845899723
-
Potential antiinflammatory role of insulin via the preferential polarization of effector T cells toward a T helper 2 phenotype
-
Viardot A., Grey S.T., Mackay F., Chisholm D. Potential antiinflammatory role of insulin via the preferential polarization of effector T cells toward a T helper 2 phenotype. Endocrinology 2007, 148:346-353.
-
(2007)
Endocrinology
, vol.148
, pp. 346-353
-
-
Viardot, A.1
Grey, S.T.2
Mackay, F.3
Chisholm, D.4
-
120
-
-
5144222442
-
Transcriptome and proteome expression in activated human CD4 and CD8 T-lymphocytes
-
Stentz F.B., Kitabchi A.E. Transcriptome and proteome expression in activated human CD4 and CD8 T-lymphocytes. Biochem Biophys Res Commun 2004, 324:692-696.
-
(2004)
Biochem Biophys Res Commun
, vol.324
, pp. 692-696
-
-
Stentz, F.B.1
Kitabchi, A.E.2
-
121
-
-
0021865626
-
Insulin-induced desensitization at the receptor and postreceptor level in mitogen-activated human lymphocytes-T
-
Ercolani L., Lin H.L., Ginsberg B.H. Insulin-induced desensitization at the receptor and postreceptor level in mitogen-activated human lymphocytes-T. Diabetes 1985, 34:931-937.
-
(1985)
Diabetes
, vol.34
, pp. 931-937
-
-
Ercolani, L.1
Lin, H.L.2
Ginsberg, B.H.3
-
122
-
-
0021069639
-
Properties and regulation of the T lymphocyte insulin receptor
-
Brown T.J., Ercolani L., Ginsberg B.H. Properties and regulation of the T lymphocyte insulin receptor. J Recept Res 1983, 3:481-494.
-
(1983)
J Recept Res
, vol.3
, pp. 481-494
-
-
Brown, T.J.1
Ercolani, L.2
Ginsberg, B.H.3
-
123
-
-
0035903192
-
Activation of the hexosamine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress
-
Kaneto H., Xu G., Song K.H., Suzuma K., Bonner-Weir S., Sharma A., Weir G.C. Activation of the hexosamine pathway leads to deterioration of pancreatic beta-cell function through the induction of oxidative stress. J Biol Chem 2001, 276:31099-31104.
-
(2001)
J Biol Chem
, vol.276
, pp. 31099-31104
-
-
Kaneto, H.1
Xu, G.2
Song, K.H.3
Suzuma, K.4
Bonner-Weir, S.5
Sharma, A.6
Weir, G.C.7
-
124
-
-
84871238193
-
Activated glucose-6-phosphate dehydrogenase is associated with insulin resistance by upregulating pentose and pentosidine in diet-induced obesity of rats
-
Wang F., Zhao Y., Niu Y., Wang C., Wang M., Li Y., Sun C. Activated glucose-6-phosphate dehydrogenase is associated with insulin resistance by upregulating pentose and pentosidine in diet-induced obesity of rats. Horm Metab Res 2012, 44:938-942.
-
(2012)
Horm Metab Res
, vol.44
, pp. 938-942
-
-
Wang, F.1
Zhao, Y.2
Niu, Y.3
Wang, C.4
Wang, M.5
Li, Y.6
Sun, C.7
-
125
-
-
33744946045
-
Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice
-
Papathanassoglou E., El-Haschimi K., Li X.C., Matarese G., Strom T., Mantzoros C. Leptin receptor expression and signaling in lymphocytes: kinetics during lymphocyte activation, role in lymphocyte survival, and response to high fat diet in mice. J Immunol 2006, 176:7745-7752.
-
(2006)
J Immunol
, vol.176
, pp. 7745-7752
-
-
Papathanassoglou, E.1
El-Haschimi, K.2
Li, X.C.3
Matarese, G.4
Strom, T.5
Mantzoros, C.6
-
126
-
-
84875464349
-
Cutting Edge: leptin-induced ROR gamma t expression in CD4(+) T cells promotes Th17 responses in systemic lupus erythematosus
-
Yu Y.Y., Liu Y.Y., Shi F.D., Zou H.J., Matarese G., La Cava A. Cutting Edge: leptin-induced ROR gamma t expression in CD4(+) T cells promotes Th17 responses in systemic lupus erythematosus. J Immunol 2013, 190:3054-3058.
-
(2013)
J Immunol
, vol.190
, pp. 3054-3058
-
-
Yu, Y.Y.1
Liu, Y.Y.2
Shi, F.D.3
Zou, H.J.4
Matarese, G.5
La Cava, A.6
-
128
-
-
0037931305
-
Activated T lymphocytes in Type 2 diabetes: implications from in vitro studies
-
Stentz F.B., Kitabchi A.E. Activated T lymphocytes in Type 2 diabetes: implications from in vitro studies. Curr Drug Targets 2003, 4:493-503.
-
(2003)
Curr Drug Targets
, vol.4
, pp. 493-503
-
-
Stentz, F.B.1
Kitabchi, A.E.2
-
129
-
-
38949109352
-
Transcriptome and proteome expressions involved in insulin resistance in muscle and activated T-lymphocytes of patients with type 2 diabetes
-
Stentz F.B., Kitabchi A.E. Transcriptome and proteome expressions involved in insulin resistance in muscle and activated T-lymphocytes of patients with type 2 diabetes. Genom Proteom Bioinform 2007, 5:216-235.
-
(2007)
Genom Proteom Bioinform
, vol.5
, pp. 216-235
-
-
Stentz, F.B.1
Kitabchi, A.E.2
-
130
-
-
84863768946
-
Obesity is associated with activated and insulin resistant immune cells
-
Viardot A., Heilbronn L.K., Samocha-Bonet D., Mackay F., Campbell L.V., Samaras K. Obesity is associated with activated and insulin resistant immune cells. Diabetes-Metab Res 2012, 28:447-454.
-
(2012)
Diabetes-Metab Res
, vol.28
, pp. 447-454
-
-
Viardot, A.1
Heilbronn, L.K.2
Samocha-Bonet, D.3
Mackay, F.4
Campbell, L.V.5
Samaras, K.6
|