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Volumn 3, Issue 12, 2004, Pages 1537-1542

Flavopiridol, an inhibitor of transcription: Implications, problems and solutions

Author keywords

Cancer; CDK; Chemotherapy; Flavopiridol; p53; Transcription

Indexed keywords

5,6 DICHLOROBENZIMIDAZOLE RIBOSIDE; AMANITIN; ANTINEOPLASTIC AGENT; CYCLIN B; CYCLIN D; CYCLIN DEPENDENT KINASE INHIBITOR; DACTINOMYCIN; DEXAMETHASONE; DOCETAXEL; FAS LIGAND; FLAVOPIRIDOL; HISTONE DEACETYLASE INHIBITOR; HYPOXIA INDUCIBLE FACTOR 1; IRINOTECAN; NITRIC OXIDE SYNTHASE; PACLITAXEL; PROTEIN BCL 2; PROTEIN MCL 1; PROTEIN MDM2; PROTEIN P21; PROTEIN P27; PROTEIN P53; SURVIVIN; TAXANE DERIVATIVE; TRANSCRIPTION FACTOR E2F1; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNINDEXED DRUG; VASCULOTROPIN; X LINKED INHIBITOR OF APOPTOSIS;

EID: 17144391819     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.3.12.1278     Document Type: Review
Times cited : (121)

References (99)
  • 4
    • 0034162636 scopus 로고    scopus 로고
    • Preclinical and clinical development of cyclin-dependent kinase modulators
    • Senderowicz AM, Sausville EA. Preclinical and clinical development of cyclin-dependent kinase modulators. J Natl Cancer Inst 2000; 92:378-87.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 378-387
    • Senderowicz, A.M.1    Sausville, E.A.2
  • 5
    • 2942582482 scopus 로고    scopus 로고
    • Flavopiridol: Pleiotropic biological effects enhance its anti-cancer activity
    • Newcomb EW. Flavopiridol: Pleiotropic biological effects enhance its anti-cancer activity. Anticancer Drugs 2004; 15:411-9.
    • (2004) Anticancer Drugs , vol.15 , pp. 411-419
    • Newcomb, E.W.1
  • 8
    • 0035679234 scopus 로고    scopus 로고
    • Augmentation of apoptosis and tumor regression by flavopiridol in the presence of CPT-11 in Hct116 colon cancer monolayers and xenografts
    • Motwani M, Jung C, Sirotnak FM, She Y, Shah MA, Gonen M, Schwartz GK. Augmentation of apoptosis and tumor regression by flavopiridol in the presence of CPT-11 in Hct116 colon cancer monolayers and xenografts. Clin Cancer Res 2001; 7:4209-19.
    • (2001) Clin Cancer Res , vol.7 , pp. 4209-4219
    • Motwani, M.1    Jung, C.2    Sirotnak, F.M.3    She, Y.4    Shah, M.A.5    Gonen, M.6    Schwartz, G.K.7
  • 11
    • 0041989795 scopus 로고    scopus 로고
    • Conversion of drug-induced differentiation to apoptosis by pharmacologic cyclin-dependent kinase inhibitors
    • Grant S, Dent P. Conversion of drug-induced differentiation to apoptosis by pharmacologic cyclin-dependent kinase inhibitors. Cell Cycle 2002; 1:383-8.
    • (2002) Cell Cycle , vol.1 , pp. 383-388
    • Grant, S.1    Dent, P.2
  • 12
    • 0036715327 scopus 로고    scopus 로고
    • Flavopiridol potentiates STI571-induced mitochondrial damage and apoptosis in BCR-ABL-positive human leukemia cells
    • Yu C, Krystal G, Dent P, Grant S. Flavopiridol potentiates STI571-induced mitochondrial damage and apoptosis in BCR-ABL-positive human leukemia cells. Clin Cancer Res 2002; 8:2976-84.
    • (2002) Clin Cancer Res , vol.8 , pp. 2976-2984
    • Yu, C.1    Krystal, G.2    Dent, P.3    Grant, S.4
  • 13
    • 0037228959 scopus 로고    scopus 로고
    • Suppression of survivin phosphorylation on Thr34 by flavopiridol enhances tumor cell apoptosis
    • Wall NR, O'Connor DS, Plescia J, Pommier Y, Altieri DC. Suppression of survivin phosphorylation on Thr34 by flavopiridol enhances tumor cell apoptosis. Cancer Res 2003; 63:230-5.
    • (2003) Cancer Res , vol.63 , pp. 230-235
    • Wall, N.R.1    O'Connor, D.S.2    Plescia, J.3    Pommier, Y.4    Altieri, D.C.5
  • 14
    • 0348075994 scopus 로고    scopus 로고
    • Flavopiridol enhances the effect of docetaxel in vitro and in vivo in human gastric cancer cells
    • Motwani M, Rizzo C, Sirotnak F, She Y, Schwartz GK. Flavopiridol enhances the effect of docetaxel in vitro and in vivo in human gastric cancer cells. Mol Cancer Ther 2003; 2:549-55.
    • (2003) Mol Cancer Ther , vol.2 , pp. 549-555
    • Motwani, M.1    Rizzo, C.2    Sirotnak, F.3    She, Y.4    Schwartz, G.K.5
  • 15
    • 0037742257 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression is a candidate target of the synergistic combination of trastuzumab and flavopiridol in breast cancer
    • Nahta R, Trent S, Yang C, Schmidt EV. Epidermal growth factor receptor expression is a candidate target of the synergistic combination of trastuzumab and flavopiridol in breast cancer. Cancer Res 2003; 63:3626-31.
    • (2003) Cancer Res , vol.63 , pp. 3626-3631
    • Nahta, R.1    Trent, S.2    Yang, C.3    Schmidt, E.V.4
  • 16
    • 0037674946 scopus 로고    scopus 로고
    • Enhancement of depsipeptide-mediated apoptosis of lung or esophageal cancer cells by flavopiridol: Activation of the mitochondria-dependent death-signaling pathway
    • Nguyen DM, Schrump WD, Tsai WS, Chen A, Stewart JH 4th, Steiner F, Schrump DS. Enhancement of depsipeptide-mediated apoptosis of lung or esophageal cancer cells by flavopiridol: Activation of the mitochondria-dependent death-signaling pathway. J Thorac Cardiovasc Surg 2003; 125:1132-42.
    • (2003) J Thorac Cardiovasc Surg , vol.125 , pp. 1132-1142
    • Nguyen, D.M.1    Schrump, W.D.2    Tsai, W.S.3    Chen, A.4    Stewart IV, J.H.5    Steiner, F.6    Schrump, D.S.7
  • 17
    • 0038745560 scopus 로고    scopus 로고
    • Flavopitidol, a cyclin-dependent kinase inhibitor, enhances radiosensitivity of ovarian carcinoma cells
    • Raju U, Nakata E, Mason KA, Ang KK, Milas L. Flavopitidol, a cyclin-dependent kinase inhibitor, enhances radiosensitivity of ovarian carcinoma cells. Cancer Res 2003; 63:3263-7.
    • (2003) Cancer Res , vol.63 , pp. 3263-3267
    • Raju, U.1    Nakata, E.2    Mason, K.A.3    Ang, K.K.4    Milas, L.5
  • 22
    • 0043011497 scopus 로고    scopus 로고
    • Phase II study of flavopiridol in patients with advanced colorectal cancer
    • Aklilu M, Kindler HL, Donehower RC, Mani S, Vokes EE. Phase II study of flavopiridol in patients with advanced colorectal cancer. Ann Oncol 2003; 14:1270-3.
    • (2003) Ann Oncol , vol.14 , pp. 1270-1273
    • Aklilu, M.1    Kindler, H.L.2    Donehower, R.C.3    Mani, S.4    Vokes, E.E.5
  • 23
    • 0033955395 scopus 로고    scopus 로고
    • Flavopiridol, a novel cyclin-dependent kinase inhibitor, in metastatic renal cancer: A university of Chicago Phase II Consortium study
    • Stadler WM, Vogelzang NJ, Amato R, Sosman J, Taber D, Liebowitz D, Vokes EE. Flavopiridol, a novel cyclin-dependent kinase inhibitor, in metastatic renal cancer: A university of Chicago Phase II Consortium study. J Clin Oncol 2000; 18:371-5.
    • (2000) J Clin Oncol , vol.18 , pp. 371-375
    • Stadler, W.M.1    Vogelzang, N.J.2    Amato, R.3    Sosman, J.4    Taber, D.5    Liebowitz, D.6    Vokes, E.E.7
  • 29
    • 85011941083 scopus 로고    scopus 로고
    • Smith SM, Liebowitz D, van Besien K, Fishkin P, Grinblatt D, Vokes EE. Flavopiridol monotherapy is inactive in mantle cell lymphoma. Blood 2003; 102:306B-306B, 4948(Part)4942.
    • Blood , vol.4948 , Issue.PART , pp. 4942
  • 30
    • 2342452448 scopus 로고    scopus 로고
    • Neutropenic enterocolitis (typhilitis) associated with docetaxel therapy in a patient with nonsmall-cell lung cancer: Case report and review of literature
    • D'Amato G, Lima CR, Mahany JJ, Muro-Cacho C, Haura EB. Neutropenic enterocolitis (typhilitis) associated with docetaxel therapy in a patient with nonsmall-cell lung cancer: Case report and review of literature. Lung Cancer 2004; 44:381-90.
    • (2004) Lung Cancer , vol.44 , pp. 381-390
    • D'Amato, G.1    Lima, C.R.2    Mahany, J.J.3    Muro-Cacho, C.4    Haura, E.B.5
  • 32
    • 0032031706 scopus 로고    scopus 로고
    • Identification of multiple cyclin subunits of human P-TEFb
    • Peng J, Zhu Y, Milton JT, Price DH. Identification of multiple cyclin subunits of human P-TEFb. Genes Dev 1998; 12:755-62.
    • (1998) Genes Dev , vol.12 , pp. 755-762
    • Peng, J.1    Zhu, Y.2    Milton, J.T.3    Price, D.H.4
  • 33
    • 0035943710 scopus 로고    scopus 로고
    • Flavopiridoi inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo
    • Chao SH, Price DH. Flavopiridoi inactivates P-TEFb and blocks most RNA polymerase II transcription in vivo. J Biol Chem 2001; 276:31793-9.
    • (2001) J Biol Chem , vol.276 , pp. 31793-31799
    • Chao, S.H.1    Price, D.H.2
  • 35
  • 36
    • 1642441939 scopus 로고    scopus 로고
    • Coordination of transcription, RNA processing, and surveillance by P-TEFb kinase on heat shock genes
    • Ni Z, Schwartz BE, Werner J, Suarez JR, Lis JT. Coordination of transcription, RNA processing, and surveillance by P-TEFb kinase on heat shock genes. Mol Cell 2004; 13:55-65.
    • (2004) Mol Cell , vol.13 , pp. 55-65
    • Ni, Z.1    Schwartz, B.E.2    Werner, J.3    Suarez, J.R.4    Lis, J.T.5
  • 37
    • 1842832323 scopus 로고    scopus 로고
    • CDK9: From basal transcription to cancer and AIDS
    • De Falco G, Giordano A. CDK9: From basal transcription to cancer and AIDS. Cancer Biol Ther 2002; 1:342-7.
    • (2002) Cancer Biol Ther , vol.1 , pp. 342-347
    • De Falco, G.1    Giordano, A.2
  • 38
    • 3242769187 scopus 로고    scopus 로고
    • Cellular control of gene expression by T-type cyclin/CDK9 complexes
    • Garriga J, Grana X. Cellular control of gene expression by T-type cyclin/CDK9 complexes. Gene 2004; 337:15-23.
    • (2004) Gene , vol.337 , pp. 15-23
    • Garriga, J.1    Grana, X.2
  • 39
    • 0034111019 scopus 로고    scopus 로고
    • P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II
    • Price DH. P-TEFb, a cyclin-dependent kinase controlling elongation by RNA polymerase II. Mol Cell Biol 2000; 20:2629-34.
    • (2000) Mol Cell Biol , vol.20 , pp. 2629-2634
    • Price, D.H.1
  • 40
    • 0033554609 scopus 로고    scopus 로고
    • RNA synthesis block by 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) triggers p53-dependent apoptosis in human colon carcinoma cells
    • Poele RHT, Okorokov AL, Joel SP. RNA synthesis block by 5,6-dichloro-1-β-D-ribofuranosylbenzimidazole (DRB) triggers p53-dependent apoptosis in human colon carcinoma cells. Oncogene 1999; 18:5765-72.
    • (1999) Oncogene , vol.18 , pp. 5765-5772
    • Poele, R.H.T.1    Okorokov, A.L.2    Joel, S.P.3
  • 41
    • 0004820949 scopus 로고
    • Actinomycin and DNA transcription
    • Sobell HM. Actinomycin and DNA transcription. Proc Natl Acad Sci USA 1985; 82:5328-31.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 5328-5331
    • Sobell, H.M.1
  • 42
    • 0016751276 scopus 로고
    • Actinomycin D as the primary agent for gestational trophoblastic disease
    • Osathanondh R, Goldstein DP, Pastorfide GB. Actinomycin D as the primary agent for gestational trophoblastic disease. Cancer 1975; 36:863-6.
    • (1975) Cancer , vol.36 , pp. 863-866
    • Osathanondh, R.1    Goldstein, D.P.2    Pastorfide, G.B.3
  • 43
    • 2442678063 scopus 로고    scopus 로고
    • Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and, independently of p53, sensitizes apoptosis-reluctant cells to tumor necrosis factor
    • Demidenko ZN, Blagosklonny MV. Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and, independently of p53, sensitizes apoptosis-reluctant cells to tumor necrosis factor. Cancer Res 2004; 64:3653-60.
    • (2004) Cancer Res , vol.64 , pp. 3653-3660
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 44
    • 0040932434 scopus 로고    scopus 로고
    • The novel cyclin-dependent kinase inhibitor flavopiridol downregulates Bcl-2 and induces growth arrest and apoptosis in chronic B-cell leukemia lines
    • Konig A, Schwartz GK, Mohammad RM, Al-Katib A, Gabrilove JL. The novel cyclin-dependent kinase inhibitor flavopiridol downregulates Bcl-2 and induces growth arrest and apoptosis in chronic B-cell leukemia lines. Blood 1997; 90:4307-12.
    • (1997) Blood , vol.90 , pp. 4307-4312
    • Konig, A.1    Schwartz, G.K.2    Mohammad, R.M.3    Al-Katib, A.4    Gabrilove, J.L.5
  • 46
    • 0033231301 scopus 로고    scopus 로고
    • Flavopiridol, a protein kinase inhibitor, down-regulates hypoxic induction of vascular endothelial growth factor expression in human monocytes
    • Melillo G, Sausville EA, Cloud K, Lahusen T, Varesio L, Senderowicz AM. Flavopiridol, a protein kinase inhibitor, down-regulates hypoxic induction of vascular endothelial growth factor expression in human monocytes. Cancer Res 1999; 59:5433-7.
    • (1999) Cancer Res , vol.59 , pp. 5433-5437
    • Melillo, G.1    Sausville, E.A.2    Cloud, K.3    Lahusen, T.4    Varesio, L.5    Senderowicz, A.M.6
  • 47
    • 0034661538 scopus 로고    scopus 로고
    • Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia
    • Kitada S, Zapata J, Andreeff M, Reed JC. Protein kinase inhibitors flavopiridol and 7-hydroxy-staurosporine down-regulate antiapoptosis proteins in B-cell chronic lymphocytic leukemia. Blood 2000; 96:393-7.
    • (2000) Blood , vol.96 , pp. 393-397
    • Kitada, S.1    Zapata, J.2    Andreeff, M.3    Reed, J.C.4
  • 48
    • 0036850211 scopus 로고    scopus 로고
    • The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1
    • Gojo I, Zhang B, Fenton RG. The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in multiple myeloma cells through transcriptional repression and down-regulation of Mcl-1. Clin Cancer Res 2002; 8:3527-38.
    • (2002) Clin Cancer Res , vol.8 , pp. 3527-3538
    • Gojo, I.1    Zhang, B.2    Fenton, R.G.3
  • 49
    • 0038754616 scopus 로고    scopus 로고
    • Flavopiridol-induced apoptosis is mediated through up-regulation of E2F1 and repression of Mcl-1
    • Ma Y, Cress WD, Haura EB. Flavopiridol-induced apoptosis is mediated through up-regulation of E2F1 and repression of Mcl-1. Mol Cancer Ther 2003; 2:73-81.
    • (2003) Mol Cancer Ther , vol.2 , pp. 73-81
    • Ma, Y.1    Cress, W.D.2    Haura, E.B.3
  • 53
    • 4444331760 scopus 로고    scopus 로고
    • Gene profiling and the cyclin-dependent kinase inhibitor flavopiridol: What's in a name?
    • Grant S, Dent P. Gene profiling and the cyclin-dependent kinase inhibitor flavopiridol: What's in a name? Mol Cancer Ther 2004; 3:873-5.
    • (2004) Mol Cancer Ther , vol.3 , pp. 873-875
    • Grant, S.1    Dent, P.2
  • 54
    • 0035866782 scopus 로고    scopus 로고
    • The cyclin-dependent kinase inhibitor (CDKI) flavopiridol disrupts phorbol 12-myristate 13-acecate-induced differentiation and CDKI expression while enhancing apoptosis in human myeloid leukemia cells
    • Cartee L, Wang Z, Decker RH, Chellappan SP, Fusaro G, Hirsch KG, Sankala HM, Dent P, Grant S. The cyclin-dependent kinase inhibitor (CDKI) flavopiridol disrupts phorbol 12-myristate 13-acecate-induced differentiation and CDKI expression while enhancing apoptosis in human myeloid leukemia cells. Cancer Res 2001; 61:2583-91.
    • (2001) Cancer Res , vol.61 , pp. 2583-2591
    • Cartee, L.1    Wang, Z.2    Decker, R.H.3    Chellappan, S.P.4    Fusaro, G.5    Hirsch, K.G.6    Sankala, H.M.7    Dent, P.8    Grant, S.9
  • 55
    • 1842481018 scopus 로고    scopus 로고
    • Abrogation of p21 expression by flavopiridol enhances depsipeptide-mediated apoptosis in malignant pleural mesothelioma cells
    • Nguyen DM, Schrump WD, Chen GA, Tsai W, Nguyen P, Trepel JB, Schrump DS. Abrogation of p21 expression by flavopiridol enhances depsipeptide-mediated apoptosis in malignant pleural mesothelioma cells. Clin Cancer Res 2004; 10:1813-25.
    • (2004) Clin Cancer Res , vol.10 , pp. 1813-1825
    • Nguyen, D.M.1    Schrump, W.D.2    Chen, G.A.3    Tsai, W.4    Nguyen, P.5    Trepel, J.B.6    Schrump, D.S.7
  • 56
    • 0041327168 scopus 로고    scopus 로고
    • Proliferation of cancer cells despite CDK2 inhibition
    • Tetsu O, McCormick F. Proliferation of cancer cells despite CDK2 inhibition. Cancer Cell 2003; 3:233-45.
    • (2003) Cancer Cell , vol.3 , pp. 233-245
    • Tetsu, O.1    McCormick, F.2
  • 58
    • 1542357279 scopus 로고    scopus 로고
    • Cdk2 as a master of S phase entry: Fact or fake?
    • Aleem E, Berthet C, Kaldis P. Cdk2 as a master of S phase entry: Fact or fake? Cell Cycle 2004; 3:35-7.
    • (2004) Cell Cycle , vol.3 , pp. 35-37
    • Aleem, E.1    Berthet, C.2    Kaldis, P.3
  • 59
    • 0029904810 scopus 로고    scopus 로고
    • Flavopiridol: A cytotoxic flavone that induces cell death in non-cycling A549 human lung carcinoma cells
    • Bible KC, Kaufmann SH. Flavopiridol: A cytotoxic flavone that induces cell death in non-cycling A549 human lung carcinoma cells. Cancer Res 1996; 56:4856-61.
    • (1996) Cancer Res , vol.56 , pp. 4856-4861
    • Bible, K.C.1    Kaufmann, S.H.2
  • 60
    • 0021812760 scopus 로고
    • Regulation of thymidine kinase activity in the cell cycle by a labile protein
    • Coppock DL, Pardee AB. Regulation of thymidine kinase activity in the cell cycle by a labile protein. J Cell Physiol 1985; 124:269-74.
    • (1985) J Cell Physiol , vol.124 , pp. 269-274
    • Coppock, D.L.1    Pardee, A.B.2
  • 61
    • 0031416213 scopus 로고    scopus 로고
    • Transcription abnormalities potentiate apoptosis of normal human fibroblasts
    • Andera L, Wasylyk B. Transcription abnormalities potentiate apoptosis of normal human fibroblasts. Mol Medicine 1997; 3:852-63.
    • (1997) Mol Medicine , vol.3 , pp. 852-863
    • Andera, L.1    Wasylyk, B.2
  • 62
    • 0030666852 scopus 로고    scopus 로고
    • Transformed cells require continuous activity of RNA polymerase II to resist oncogene-induced apoptosis
    • Koumenis C, Giaccia A. Transformed cells require continuous activity of RNA polymerase II to resist oncogene-induced apoptosis. Mol Cell Biol 1997; 17:7306-16.
    • (1997) Mol Cell Biol , vol.17 , pp. 7306-7316
    • Koumenis, C.1    Giaccia, A.2
  • 63
    • 0032724295 scopus 로고    scopus 로고
    • Flavopiridol induces cell cycle arrest and p53-independent apoptosis in nonsmall cell lung cancer cell lines
    • Shapiro GI, Koestner DA, Matranga CB, Rollins BJ. Flavopiridol induces cell cycle arrest and p53-independent apoptosis in nonsmall cell lung cancer cell lines. Clin Cancer Res 1999; 5:2925-38.
    • (1999) Clin Cancer Res , vol.5 , pp. 2925-2938
    • Shapiro, G.I.1    Koestner, D.A.2    Matranga, C.B.3    Rollins, B.J.4
  • 64
    • 0036490992 scopus 로고    scopus 로고
    • CDK inhibitors: Cell cycle arrest versus apoptosis
    • Schwartz GK. CDK inhibitors: Cell cycle arrest versus apoptosis. Cell Cycle 2002; 1:122-3.
    • (2002) Cell Cycle , vol.1 , pp. 122-123
    • Schwartz, G.K.1
  • 65
    • 0141499968 scopus 로고    scopus 로고
    • Flavopiridol induces mitochondrial-mediated apoptosis in murine glioma GL261 cells via release of cytochrome c and apoptosis inducing factor
    • Newcomb EW, Tamasdan C, Entzminger Y, Alonso J, Friedlander D, Crisan D, Miller DC, Zagzag D. Flavopiridol induces mitochondrial-mediated apoptosis in murine glioma GL261 cells via release of cytochrome c and apoptosis inducing factor. Cell Cycle 2003; 2:243-50.
    • (2003) Cell Cycle , vol.2 , pp. 243-250
    • Newcomb, E.W.1    Tamasdan, C.2    Entzminger, Y.3    Alonso, J.4    Friedlander, D.5    Crisan, D.6    Miller, D.C.7    Zagzag, D.8
  • 66
    • 9444297849 scopus 로고    scopus 로고
    • Local cyclin-dependent kinase inhibition by flavopiridol inhibits coronary artery smooth muscle cell proliferation and migration: Implications for the applicability on drug-eluting stents to prevent neointima formation following vascular injury
    • Jaschke B, Milz S, Vogeser M, Michaelis C, Vorpahl M, Schomig A, Kastrati A, Wessely R. Local cyclin-dependent kinase inhibition by flavopiridol inhibits coronary artery smooth muscle cell proliferation and migration: Implications for the applicability on drug-eluting stents to prevent neointima formation following vascular injury. FASEB J 2004; 18:1285-7.
    • (2004) FASEB J , vol.18 , pp. 1285-1287
    • Jaschke, B.1    Milz, S.2    Vogeser, M.3    Michaelis, C.4    Vorpahl, M.5    Schomig, A.6    Kastrati, A.7    Wessely, R.8
  • 68
    • 0037151079 scopus 로고    scopus 로고
    • An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis
    • Kim Y, Suh N, Sporn M, Reed JC. An inducible pathway for degradation of FLIP protein sensitizes tumor cells to TRAIL-induced apoptosis. J Biol Chem 2002; 277:22320-9.
    • (2002) J Biol Chem , vol.277 , pp. 22320-22329
    • Kim, Y.1    Suh, N.2    Sporn, M.3    Reed, J.C.4
  • 69
    • 0035196350 scopus 로고    scopus 로고
    • Actinomycin D and gemcitabine synergistically sensitize androgen-independent prostate cancer cells to Apo2L/TRAIL-mediated apoptosis
    • Zisman A, Ng CP, Pantuck AJ, Bonavida B, Belldegrun AS. Actinomycin D and gemcitabine synergistically sensitize androgen-independent prostate cancer cells to Apo2L/TRAIL-mediated apoptosis. J Immunother 2001; 24:459-71.
    • (2001) J Immunother , vol.24 , pp. 459-471
    • Zisman, A.1    Ng, C.P.2    Pantuck, A.J.3    Bonavida, B.4    Belldegrun, A.S.5
  • 70
    • 0035195486 scopus 로고    scopus 로고
    • Sensitization to TRAIL-induced apoptosis and modulation of FLICE-inhibitory protein in B chronic lymphocytic leukemia by actinomycin D
    • Olsson A, Diaz T, Aguilac-Santelises M, Osterborg A, Celsing F, Jondal M, Osorio LM. Sensitization to TRAIL-induced apoptosis and modulation of FLICE-inhibitory protein in B chronic lymphocytic leukemia by actinomycin D. Leukemia 2001; 15:1868-77.
    • (2001) Leukemia , vol.15 , pp. 1868-1877
    • Olsson, A.1    Diaz, T.2    Aguilac-Santelises, M.3    Osterborg, A.4    Celsing, F.5    Jondal, M.6    Osorio, L.M.7
  • 71
    • 0034660874 scopus 로고    scopus 로고
    • Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression
    • Fulda S, Meyer E, Debatin KM. Metabolic inhibitors sensitize for CD95 (APO-1/Fas)-induced apoptosis by down-regulating Fas-associated death domain-like interleukin 1-converting enzyme inhibitory protein expression. Cancer Res 2000; 60:3947-56.
    • (2000) Cancer Res , vol.60 , pp. 3947-3956
    • Fulda, S.1    Meyer, E.2    Debatin, K.M.3
  • 72
    • 0028204376 scopus 로고
    • Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways
    • Wong GHW, Goeddel DV. Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways. J Immunol 1994; 152:1751-5.
    • (1994) J Immunol , vol.152 , pp. 1751-1755
    • Wong, G.H.W.1    Goeddel, D.V.2
  • 73
    • 0037311226 scopus 로고    scopus 로고
    • Rapid induction of apoptosis by combination of flavopiridol and tumor necrosis factor (TNF)-α or TNF-related apoptosis-inducing ligand in human cancer cell lines
    • Kim DM, Koo SY, Jeon K, Kim MH, Lee J, Hong CY, Jeong S. Rapid induction of apoptosis by combination of flavopiridol and tumor necrosis factor (TNF)-α or TNF-related apoptosis-inducing ligand in human cancer cell lines. Cancer Res 2003; 63:621-6.
    • (2003) Cancer Res , vol.63 , pp. 621-626
    • Kim, D.M.1    Koo, S.Y.2    Jeon, K.3    Kim, M.H.4    Lee, J.5    Hong, C.Y.6    Jeong, S.7
  • 74
    • 0032804733 scopus 로고    scopus 로고
    • Sequential dependent enhancement of caspase activation and apoptosis by flavopiridol on paclitaxel-treated human gastric and breast cancer cells
    • Motwani M, Delohery TM, Schwartz GK. Sequential dependent enhancement of caspase activation and apoptosis by flavopiridol on paclitaxel-treated human gastric and breast cancer cells. Clin Cancer Res 1999; 5:1876-83.
    • (1999) Clin Cancer Res , vol.5 , pp. 1876-1883
    • Motwani, M.1    Delohery, T.M.2    Schwartz, G.K.3
  • 75
    • 4844224868 scopus 로고    scopus 로고
    • Contribution of disruption of the NF-κB pathway to induction of apoptosis in human leukemia cells by histone deacetylase inhibitors and flavopiridol
    • Gao N, Dai Y, Rahmani M, Dent P, Grant S. Contribution of disruption of the NF-κB pathway to induction of apoptosis in human leukemia cells by histone deacetylase inhibitors and flavopiridol. Mol Pharmacol 2004; 66:956-63.
    • (2004) Mol Pharmacol , vol.66 , pp. 956-963
    • Gao, N.1    Dai, Y.2    Rahmani, M.3    Dent, P.4    Grant, S.5
  • 76
    • 3142554015 scopus 로고    scopus 로고
    • Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms
    • Dai Y, Rahmani M, Pei XY, Dent P, Grant S. Bortezomib and flavopiridol interact synergistically to induce apoptosis in chronic myeloid leukemia cells resistant to imatinib mesylate through both Bcr/Abl-dependent and -independent mechanisms. Blood 2004; 104:509-18.
    • (2004) Blood , vol.104 , pp. 509-518
    • Dai, Y.1    Rahmani, M.2    Pei, X.Y.3    Dent, P.4    Grant, S.5
  • 77
    • 0032505719 scopus 로고    scopus 로고
    • Inhibitors of transcription, proteasome inhibitors, and DNA-damaging drugs differentially affect feedback of p53 degradation
    • An WG, Chuman Y, Fojo T, Blagosklonny MV. Inhibitors of transcription, proteasome inhibitors, and DNA-damaging drugs differentially affect feedback of p53 degradation. Exp Cell Res 1998; 244:54-60.
    • (1998) Exp Cell Res , vol.244 , pp. 54-60
    • An, W.G.1    Chuman, Y.2    Fojo, T.3    Blagosklonny, M.V.4
  • 78
    • 0036044958 scopus 로고    scopus 로고
    • Inhibition of transcription results in accumulation of Wt p53 followed by delayed outburst of p53-inducible proteins: P53 as a sensor of transcriptional integrity
    • Blagosklonny MV, Demidenko ZN, Fojo T. Inhibition of transcription results in accumulation of Wt p53 followed by delayed outburst of p53-inducible proteins: P53 as a sensor of transcriptional integrity. Cell Cycle 2002; 1:67-74.
    • (2002) Cell Cycle , vol.1 , pp. 67-74
    • Blagosklonny, M.V.1    Demidenko, Z.N.2    Fojo, T.3
  • 79
    • 0033920566 scopus 로고    scopus 로고
    • Protease inhibitor-induced apoptosis: Accumulation wt p53, p21 WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition
    • An WG, Hwang SG, Trepel JB, Blagosklonny MV. Protease inhibitor-induced apoptosis: Accumulation wt p53, p21 WAF1/CIP1, and induction of apoptosis are independent markers of proteasome inhibition. Leukemia 2000; 14:1276-83.
    • (2000) Leukemia , vol.14 , pp. 1276-1283
    • An, W.G.1    Hwang, S.G.2    Trepel, J.B.3    Blagosklonny, M.V.4
  • 80
    • 0041488913 scopus 로고    scopus 로고
    • Flavopiridol induces apoptosis in glioma cell lines independent of retinoblastoma and p53 tumor suppressor pathway alterations by a caspase-independent pathway
    • Alonso M, Tamasdan C, Miller DC, Newcomb EW. Flavopiridol induces apoptosis in glioma cell lines independent of retinoblastoma and p53 tumor suppressor pathway alterations by a caspase-independent pathway. Mol Cancer Ther 2003; 2:139-50.
    • (2003) Mol Cancer Ther , vol.2 , pp. 139-150
    • Alonso, M.1    Tamasdan, C.2    Miller, D.C.3    Newcomb, E.W.4
  • 81
    • 0042697735 scopus 로고    scopus 로고
    • Leukemic and non-leukemic lymphocytes from patients with Li Fraumeni syndrome demonstrate loss of p53 function, Bcl-2 family dysregulation and intrinsic resistance to conventional chemotherapeutic drugs but not flavopiridol
    • Pepper C, Thomas A, Hoy T, Tighe J, Culligan D, Fegan C, Bentley P. Leukemic and non-leukemic lymphocytes from patients with Li Fraumeni syndrome demonstrate loss of p53 function, Bcl-2 family dysregulation and intrinsic resistance to conventional chemotherapeutic drugs but not flavopiridol. Cell Cycle 2003; 2:53-8.
    • (2003) Cell Cycle , vol.2 , pp. 53-58
    • Pepper, C.1    Thomas, A.2    Hoy, T.3    Tighe, J.4    Culligan, D.5    Fegan, C.6    Bentley, P.7
  • 82
    • 0032939925 scopus 로고    scopus 로고
    • Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53
    • Blattner C, Sparks A, Lane D. Transcription factor E2F-1 is upregulated in response to DNA damage in a manner analogous to that of p53. Mol Cell Biol 1999; 19:3704-13.
    • (1999) Mol Cell Biol , vol.19 , pp. 3704-3713
    • Blattner, C.1    Sparks, A.2    Lane, D.3
  • 84
    • 0037031929 scopus 로고    scopus 로고
    • Bisindolylmaleimide IX facilitates tumor necrosis factor receptor family-mediated cell death and acts as an inhibitor of transcription
    • Rokhlin OW, Glover RA, Taghiyev AF, Guseva NV, Seftor RE, Shyshynova I, Gudkov AV, Cohen MB. Bisindolylmaleimide IX facilitates tumor necrosis factor receptor family-mediated cell death and acts as an inhibitor of transcription. J Biol Chem 2002; 277:33213-9.
    • (2002) J Biol Chem , vol.277 , pp. 33213-33219
    • Rokhlin, O.W.1    Glover, R.A.2    Taghiyev, A.F.3    Guseva, N.V.4    Seftor, R.E.5    Shyshynova, I.6    Gudkov, A.V.7    Cohen, M.B.8
  • 85
    • 4544259868 scopus 로고    scopus 로고
    • Opinion: Transcription - Guarding the genome by sensing DNA damage
    • Ljungman M, DP L. Opinion: Transcription - Guarding the genome by sensing DNA damage. Nat Rev Cancer 2004; 4:727-37.
    • (2004) Nat Rev Cancer , vol.4 , pp. 727-737
    • Ljungman, M.1    Dp, L.2
  • 86
    • 0034973788 scopus 로고    scopus 로고
    • Activation of p53 by roscovitine-mediated suppression of MDM2 expression
    • Lu W Chen L, Peng Y, Chen J. Activation of p53 by roscovitine-mediated suppression of MDM2 expression. Oncogene 2001; 20:3206-16.
    • (2001) Oncogene , vol.20 , pp. 3206-3216
    • Lu, W.1    Chen, L.2    Peng, Y.3    Chen, J.4
  • 89
    • 3042536038 scopus 로고    scopus 로고
    • Preclinical and clinical development of the cyclin-dependent kinase inhibitor flavopiridol
    • Shapiro GI. Preclinical and clinical development of the cyclin-dependent kinase inhibitor flavopiridol. Clin Cancer Res 2004; 0(12 Pt 2):4270s-5s.
    • (2004) Clin Cancer Res , Issue.12 PART 2
    • Shapiro, G.I.1
  • 90
    • 1542299692 scopus 로고    scopus 로고
    • Do cells need CDK2 and Bcr-Abl?
    • Blagosklonny MV. Do cells need CDK2 and Bcr-Abl? Cell Death Differ 2004; 11:249-51.
    • (2004) Cell Death Differ , vol.11 , pp. 249-251
    • Blagosklonny, M.V.1
  • 92
    • 0025319864 scopus 로고
    • Shared actions of endotoxin and taxol on TNF receptors and TNF release
    • Ding AH, Porteu F, Sanchez E, Nathan CF. Shared actions of endotoxin and taxol on TNF receptors and TNF release. Science 1990; 248:370-2.
    • (1990) Science , vol.248 , pp. 370-372
    • Ding, A.H.1    Porteu, F.2    Sanchez, E.3    Nathan, C.F.4
  • 93
    • 0034686615 scopus 로고    scopus 로고
    • Re: Preclinical and clinical development of cyclin-dependent kinase modulators
    • Darzynkiewicz Z. Re: Preclinical and clinical development of cyclin-dependent kinase modulators. J Natl Cancer Inst 2000; 92:1184-5.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1184-1185
    • Darzynkiewicz, Z.1
  • 95
    • 0012203929 scopus 로고    scopus 로고
    • Role reversal for anti cancer agents
    • Pardee A. Role reversal for anti cancer agents. Cancer Biol Ther 2002; 1:426-7.
    • (2002) Cancer Biol Ther , vol.1 , pp. 426-427
    • Pardee, A.1
  • 96
    • 0012177733 scopus 로고    scopus 로고
    • Cyclotherapy: Protection of normal cells and unshielding of cancer cells
    • Blagosklonny MV, Darzynkiewicz Z. Cyclotherapy: Protection of normal cells and unshielding of cancer cells. Cell Cycle 2002; 1:375-82.
    • (2002) Cell Cycle , vol.1 , pp. 375-382
    • Blagosklonny, M.V.1    Darzynkiewicz, Z.2
  • 97
    • 8844228917 scopus 로고    scopus 로고
    • Potent antileukemic interactions between flavopiridol and TRAIL/Apo2L involve flavopiridol-mediated XIAP downregulation
    • In press
    • Rosato RR, Dai Y, Almenara JA, Maggio SC, Grant S. Potent antileukemic interactions between flavopiridol and TRAIL/Apo2L involve flavopiridol-mediated XIAP downregulation. Leukemia 2004; In press.
    • (2004) Leukemia
    • Rosato, R.R.1    Dai, Y.2    Almenara, J.A.3    Maggio, S.C.4    Grant, S.5
  • 98
    • 1242342082 scopus 로고    scopus 로고
    • Inhibition of human immunodeficiency virus type 1 replication by RNA interference directed against human transcription elongation factor P-TEFb (CDK9/CyclinT1)
    • Chiu YL, Cao H, Jacque JM, Stevenson M, Rana TM. Inhibition of human immunodeficiency virus type 1 replication by RNA interference directed against human transcription elongation factor P-TEFb (CDK9/CyclinT1). J Virol 2004; 78:2517-29.
    • (2004) J Virol , vol.78 , pp. 2517-2529
    • Chiu, Y.L.1    Cao, H.2    Jacque, J.M.3    Stevenson, M.4    Rana, T.M.5
  • 99
    • 1542269011 scopus 로고    scopus 로고
    • Effects of pharmacological cyclin-dependent kinase inhibitors on viral transcription and replication
    • Schang LM. Effects of pharmacological cyclin-dependent kinase inhibitors on viral transcription and replication. Biochim Biophys Acta 2004; 1697:197-209.
    • (2004) Biochim Biophys Acta , vol.1697 , pp. 197-209
    • Schang, L.M.1


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