Conversion of Peripheral CD4+CD25- Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

Journal of Experimental Medicine

Volumn 198, Issue 12, 2003, Pages 1875-1886

  Chen, WanJun ^a   Jin, Wenwen ^a   Hardegen, Neil ^a   Lei, Ke Jian ^a   Li, Li ^a   Marinos, Nancy ^a   McGrady, George ^a   Wahl, Sharon M ^a  

^a NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

Anergy; Asthma; House dust mite; IL 10; OVA TCR transgenic

Indexed keywords

ANTIGEN; CD4 ANTIGEN; CYTOKINE; INTERLEUKIN 2 RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIGEN SPECIFICITY; ARTICLE; CELL DIFFERENTIATION; CELL STIMULATION; CLONAL ANERGY; CONTROLLED STUDY; DISEASE MODEL; DUST; GENE EXPRESSION; IMMUNIZATION; IMMUNOLOGICAL TOLERANCE; LYMPHOCYTE PROLIFERATION; MITE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; SUPPRESSOR CELL; T LYMPHOCYTE; TH2 CELL; THYMUS;

ANIMALS; ANTIGENS, CD4; DNA-BINDING PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION; HYPERSENSITIVITY; IMMUNE TOLERANCE; IMMUNOPHENOTYPING; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MITES; OVALBUMIN; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, INTERLEUKIN-2; T-LYMPHOCYTES; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA;

EID: 0348223787     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20030152     Document Type: Article

References (40)

1. Sakaguchi, S. 2000. Regulatory T cells: key controllers of immunologic self-tolerance. Cell. 101:455-458.
2. Shevach, E.M. 2002. CD4+ CD25+ suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2:389-400.
3. Itoh, M., T. Takahashi, N. Sakaguchi, Y. Kuniyasu, J. Shimizu, F. Otsuka, and S. Sakaguchi. 1999. Thymus and autoimmunity: production of CD25+CD4+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance. J. Immunol. 162:5317-5326.
4. Apostolou, I., A. Sarukhan, L. Klein, and H. von Boehmer. 2002. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol. 3:756-763.
5. Zhang, X., L. Izikson, L. Liu, and H.L. Weiner. 2001. Activation of CD25(+)CD4(+) regulatory T cells by oral antigen administration. J. Immunol. 167:4245-4253.
6. Gorelik, L., and R.A. Flavell. 2002. Transforming growth factor-beta in T-cell biology. Nat. Rev. Immunol. 2:46-53.
7. Chen, W., and S.M. Wahl. 2002. TGF-beta: receptors, signaling pathways and autoimmunity. Curr. Dir. Autoimmun. 5:62-91.
8. Gorelik, L., and R.A. Flavell. 2000. Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity. 12:171-181.
9. Lucas, P.J., S.J. Kim, S.J. Melby, and R.E. Gress. 2000. Disruption of T cell homeostasis in mice expressing a T cell-specific dominant negative transforming growth factor β 11 receptor. J. Exp. Med. 191:1187-1196.
10. Yamagiwa, S., J.D. Gray, S. Hashimoto, and D.A. Horwitz. 2001. A role for TGF-beta in the generation and expansion of CD4+CD25+ regulatory T cells from human peripheral blood. J. Immunol. 166:7282-7289.
11. Brunkow, M.E., E.W. Jeffery, K.A. Hjerrild, B. Paeper, L.B. Clark, S.A. Yasayko, J.E. Wilkinson, D. Galas, S.F. Ziegler, and F. Ramsdell. 2001. Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse. Nat. Genet. 27:68-73.
12. Wildin, R.S., F. Ramsdell, J. Peake, F. Faravelli, J.L. Casanova, N. Buist, E. Levy-Lahad, M. Mazzella, O. Goulet, L. Perroni, et al. 2001. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome in the human equivalent of mouse scurfy. Nat. Genet. 27:18-20.
13. Hori, S., T. Nomura, and S. Sakaguchi. 2003. Control of regulatory T cell development by the transcription factor Foxp3. Science. 299:1057-1061.
14. Khattri, R., T. Cox, S.A. Yasayko, and F. Ramsdell. 2003. An essential role for Scurfin in CD4(+)CD25(+) T regulatory cells. Nat. Immunol. 4:337-342.
15. Fontenot, J.D., M.A. Gavin, and A.Y. Rudensky. 2003. Foxp3 programs the development and function of CD4(+) CD25(+) regulatory T cells. Nat. Immunol. 4:330-336.
16. Tivol, E., F. Borriello, A. Schweitzer, W. Lynch, J. Bluestone, and A. Sharpe. 1995. Loss of CTLA4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction. Immunity. 3:541-547.
17. Waterhouse, P., J. Penninger, E. Timms, A. Wakeham, A. Shahinian, K. Lee, C. Thompson, H. Griesser, and T. Mak. 1995. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science. 270:985-988.
18. Kulkarni, A.B., C.-H. Huh, D. Becker, A. Gerser, M. Lyght, K.C. Flanders, A.B. Roberts, M.B. Sporn, J.M. Ward, and S. Karlsson. 1993. Transforming growth factor-β null mutation in mice causes excessive inflammatory response and early death. Proc. Natl. Acad. Sci. USA. 90:770-774.
19. Shull, M.M., I. Ormsby, A.B. Kier, S. Pawlowski, R.J. Diebold, M. Yin, R. Allen, C. Sidman, G. Proetzel, D. Calvin, et al. 1992. Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease. Nature. 359:693-699.
20. Chen, W., W. Jin, and S.M. Wahl. 1998. Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor β (TGF-β) production by murine CD4(+) T cells. J. Exp. Med. 188:1849-1857.
21. Chen, W., W. Jin, H. Tian, P. Sicurello, M. Frank, J.M. Orenstein, and S.M. Wahl. 2001. Requirement for transforming growth factor β1 in controlling T cell apoptosis. J. Exp. Med. 194:439-454.
22. + immunoregulatory T cells suppress polyclonal T cell activation in vitro by inhibiting interleukin 2 production. J. Exp. Med. 188:287-296.
23. Salomon, B., D.J. Lenschow, L. Rhee, N. Ashourian, B. Singh, A. Sharpe, and J.A. Bluestone. 2000. B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes. Immunity. 12:431-440.
24. Chen, W., M.E. Frank, W. Jin, and S.M. Wahl. 2001. TGF-beta released by apoptotic T cells contributes to an immunosuppressive milieu. Immunity. 14:715-725.
25. Wills-Karp, M., J. Luyimbazi, X. Xu, B. Schofield, T.Y. Neben, C.L. Karp, and D.D. Donaldson. 1998. Interleukin-13: central mediator of allergic asthma. Science 282:2258-2261.
26. Schwartz, R.H. 1996. Models of T cell allergy: is there a common molecular mechanism? J. Exp. Med. 184:1-8.
27. Read, S., V. Malmstrom, and F. Powrie. 2000. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J. Exp. Med. 192:295-302.
28. Takahashi, T., T. Tagami, S. Yamazaki, T. Uede, J. Shimizu, N. Sakaguchi, T.W. Mak, and S. Sakaguchi. 2000. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 192:303-310.
29. + regulatory T cells is mediated by cell surface-bound transforming growth factor β. J. Exp. Med. 194:629-644.
30. Chen, W., and S.M. Wahl. 2003. TGF-beta: the missing link in CD4(+)CD25(+) regulatory T cell mediated immunosuppression. Cytokine Growth Factor Rev. 14:85-89.
31. + regulatory T cells in vivo. J. Exp. Med. 198:249-258.
32. Kleim, L., K. Khazaie, and H. Von Boehmer. 2003. In vivo dynamics of antigen-specific regulatory T cells not predicted from behavior in vitro. Proc. Natl. Acad. Sci. USA. 100:8886-8891.
33. Bluestone, J.A., and A.K. Abbas. 2003. Natural versus adaptive regulatory T cells. Nat. Rev. Immunol. 3:253-257.
34. Maloy, K.J., and F. Powrie. 2001. Regulatory T cells in the control of immune pathology. Nat. Immunol. 2:816-822.
35. Chatenoud, L., B. Salomon, and J.A. Bluestone. 2001. Suppressor T cells-they're back and critical for regulation of autoimmunity! Immunol. Rev. 182:149-163.
36. + T helper cells. J. Exp. Med. 196:255-260.
37. Woo, E.Y., H. Yeh, C.S. Chu, K. Schlienger, R.G. Carroll, J.L. Riley, L.R. Kaiser, and C.H. June. 2002. Cutting edge: regulatory T cells from lung cancer patients directly inhibit autologous T cell proliferation. J. Immunol. 168:4272-4276.
38. Ramsdell, F. 2003. Foxp3 and natural regulatory T cells. Key to a cell lineage? Immunity. 19:165-168.
39. + T cell subset inbibits antigen-specific T cell responses and prevents colitis. Nature. 389:737-742.
40. Herrick, C.A., and K. Bottomly. 2003. To respond or not to respond: T cells in allergic asthma. Nat. Rev. Immunol. 3:405-412.