Radiosensitization by 2-deoxy-D-glucose and 6-aminonicotinamide involves activation of redox sensitive ASK1-JNK/p38MAPK signaling in head and neck cancer cells

Free Radical Biology and Medicine

Volumn 53, Issue 7, 2012, Pages 1500-1513

  Sharma, Pradeep Kumar ^a,b   Dwarakanath, Bilikere Srinivasa ^a   Varshney, Rajeev ^a,c  

^a INSTITUTE OF NUCLEAR MEDICINE AND ALLIED SCIENCES   (India)

^b GURU GOBIND SINGH INDRAPRASTHA UNIVERSITY   (India)

^c DRDO   (India)

Author keywords

2 deoxy D glucose; 6 aminonicotinamide; ASK1; Oxidative stress; Redox alterations

Indexed keywords

6 AMINONICOTINAMIDE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; APOPTOSIS SIGNAL REGULATING KINASE 1; CATALASE; DEOXYGLUCOSE; HYDROGEN PEROXIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; PENTOSE PHOSPHATE; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE DISMUTASE; THIOREDOXIN REDUCTASE;

APOPTOSIS; ARTICLE; CANCER CELL; CONTROLLED STUDY; ENZYME ACTIVATION; GLUCOSE METABOLISM; GLYCOLYSIS; HEAD AND NECK CANCER; HUMAN; HUMAN CELL; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOSENSITIZATION; SIGNAL TRANSDUCTION;

6-AMINONICOTINAMIDE; APOPTOSIS; CARCINOMA, SQUAMOUS CELL; CELL PROLIFERATION; DEOXYGLUCOSE; DRUG SYNERGISM; GAMMA RAYS; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAD AND NECK NEOPLASMS; HUMANS; MAP KINASE KINASE 4; MAP KINASE KINASE KINASE 5; OXIDATION-REDUCTION; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RADIATION TOLERANCE; RADIATION-SENSITIZING AGENTS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 84866361703     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2012.07.001     Document Type: Article

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