TP53-inducible glycolysis and apoptosis regulator (TIGAR) metabolically reprograms carcinoma and stromal cells in breast cancer

Journal of Biological Chemistry

Volumn 291, Issue 51, 2016, Pages 26291-26303

  Ko, Ying Hui ^a   Domingo Vidal, Marina ^a   Roche, Megan ^a   Lin, Zhao ^a   Whitaker Menezes, Diana ^a   Seifert, Erin ^b   Capparelli, Claudia ^a   Tuluc, Madalina ^b   Birbe, Ruth C ^c   Tassone, Patrick ^a   Curry, Joseph M ^a   Navarro Sabaté, Àurea ^d   Manzano, Anna ^d   Bartrons, Ramon ^d   Caro, Jaime ^a   Martinez Outschoorn, Ubaldo ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c Division of Female Pelvic Medicine and Reconstructive Surgery   (United States)

^d UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CELL CULTURE; CELL DEATH; CELLS; DISEASES; ENZYMES; FIBROBLASTS; GLUCOSE; METABOLISM; PATHOLOGY; SELF ASSEMBLY; TUMORS;

APOPTOSIS REGULATOR; BREAST CARCINOMA CELLS; HUMAN BREAST CANCER; HYPOXIA-INDUCIBLE FACTORS; LACTATE DEHYDROGENASE; METABOLIC PHENOTYPE; OXYGEN CONSUMPTION RATE; POTENTIAL THERAPIES;

CYTOLOGY;

6 PHOSPHOFRUCTO 2 KINASE; 6 PHOSPHOFRUCTO 2 KINASE FRUCTOSE 2,6 BISPHOSPHATASE 3; APOPTOSIS REGULATORY PROTEIN; FRUCTOSE 2,6 BISPHOSPHATASE; GLUTAMINE; HYPOXIA INDUCIBLE FACTOR; LACTATE DEHYDROGENASE; LACTIC ACID; TP53 INDUCIBLE GLYCOLYSIS AND APOPTOSIS REGULATOR PROTEIN; UNCLASSIFIED DRUG; C12ORF5 PROTEIN, HUMAN; GLUTAMIC ACID; ISOENZYME; LACTATE DEHYDROGENASE 5; PFKFB3 PROTEIN, HUMAN; PROTEIN P53; SIGNAL PEPTIDE; TP53 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; FIBROBLAST; GLUCOSE TRANSPORT; GLYCOLYSIS; HUMAN; HUMAN CELL; IN VIVO STUDY; LIMIT OF QUANTITATION; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; STROMA CELL; BREAST TUMOR; COCULTURE; GENETICS; MCF-7 CELL LINE; METABOLISM; PATHOLOGY;

APOPTOSIS; BREAST NEOPLASMS; COCULTURE TECHNIQUES; FEMALE; FIBROBLASTS; GLUTAMIC ACID; GLYCOLYSIS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISOENZYMES; L-LACTATE DEHYDROGENASE; LACTIC ACID; MCF-7 CELLS; PHOSPHOFRUCTOKINASE-2; TUMOR SUPPRESSOR PROTEIN P53;

EID: 85006294865     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.740209     Document Type: Article

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