Mode of cell death induction by pharmacological vacuolar H +-ATPase (V-ATPase) inhibition

Journal of Biological Chemistry

Volumn 288, Issue 2, 2013, Pages 1385-1396

  Von Schwarzenberg, Karin ^a   Wiedmann, Romina M ^a   Oak, Prajakta ^a   Schulz, Sabine ^b   Zischka, Hans ^b   Wanner, Gerhard ^a   Efferth, Thomas ^c   Trauner, Dirk ^a   Vollmar, Angelika M ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b INSTITUTE OF EPIDEMIOLOGY   (Germany)

^c JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTIVE MECHANISM; APOPTOSIS INDUCTION; ATP LEVEL; AUTOPHAGOSOMES; AUTOPHAGY; CANCER INVASION; CANCER THERAPY; CELLULAR STRESS RESPONSE; CHEMICAL TOOLS; HYPOXIA-INDUCIBLE FACTOR 1; INDUCED APOPTOSIS; INVASIVE TUMORS; LOW CONCENTRATIONS; MACROLIDES; MITOCHONDRIAL PATHWAYS; MULTISUBUNIT; NANOMOLAR CONCENTRATION; POTENT INHIBITOR; PROTON PUMP; UNDERLYING MECHANISM; V-ATPASE;

DRUG PRODUCTS;

CELL DEATH;

ADENOSINE TRIPHOSPHATASE INHIBITOR; ADENOSINE TRIPHOSPHATE; ARCHAZOLID B; HYPOXIA INDUCIBLE FACTOR 1ALPHA; PROTEIN P62; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; UNCLASSIFIED DRUG; VACUOLAR PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CELL DEATH; CELL FUSION; CELLULAR STRESS RESPONSE; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; LYSOSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; RAT; TUMOR CELL;

AUTOPHAGY; CELL DEATH; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOCHROMES C; ENZYME INHIBITORS; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICROSCOPY, CONFOCAL; SIGNAL TRANSDUCTION; VACUOLAR PROTON-TRANSLOCATING ATPASES;

EID: 84872288221     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.412007     Document Type: Article

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