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Volumn 316, Issue 8, 2010, Pages 1324-1331

Hallmarks of cancer: Interactions with the tumor stroma

Author keywords

Cancer; Cancer associated fibroblast; Pericyte; Targeted therapy; Tumor stroma

Indexed keywords

ANTINEOPLASTIC AGENT; PROTEIN TYROSINE KINASE INHIBITOR; SORAFENIB; SUNITINIB;

EID: 77952568396     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2010.02.045     Document Type: Review
Times cited : (926)

References (72)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell 2000, 100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 3
    • 60949101225 scopus 로고    scopus 로고
    • Cancer-associated fibroblasts and tumor growth-bystanders turning into key players
    • Ostman A., Augsten M. Cancer-associated fibroblasts and tumor growth-bystanders turning into key players. Curr. Opin. Genet. Dev. 2009, 19:67-73.
    • (2009) Curr. Opin. Genet. Dev. , vol.19 , pp. 67-73
    • Ostman, A.1    Augsten, M.2
  • 4
    • 33846967113 scopus 로고    scopus 로고
    • Identification of fibroblast heterogeneity in the tumor microenvironment
    • Sugimoto H., Mundel T.M., Kieran M.W., Kalluri R. Identification of fibroblast heterogeneity in the tumor microenvironment. Cancer Biol. Ther. 2006, 5:1640-1646.
    • (2006) Cancer Biol. Ther. , vol.5 , pp. 1640-1646
    • Sugimoto, H.1    Mundel, T.M.2    Kieran, M.W.3    Kalluri, R.4
  • 5
    • 58249095931 scopus 로고    scopus 로고
    • Paracrine signaling by platelet-derived growth factor-CC promotes tumor growth by recruitment of cancer-associated fibroblasts
    • Anderberg C., Li H., Fredriksson L., Andrae J., Betsholtz C., Li X., Eriksson U., Pietras K. Paracrine signaling by platelet-derived growth factor-CC promotes tumor growth by recruitment of cancer-associated fibroblasts. Cancer Res. 2009, 69:369-378.
    • (2009) Cancer Res. , vol.69 , pp. 369-378
    • Anderberg, C.1    Li, H.2    Fredriksson, L.3    Andrae, J.4    Betsholtz, C.5    Li, X.6    Eriksson, U.7    Pietras, K.8
  • 6
    • 66849093706 scopus 로고    scopus 로고
    • On the origin of cancer-associated fibroblasts
    • Anderberg C., Pietras K. On the origin of cancer-associated fibroblasts. Cell Cycle 2009, 8:1461-1462.
    • (2009) Cell Cycle , vol.8 , pp. 1461-1462
    • Anderberg, C.1    Pietras, K.2
  • 11
    • 0345798150 scopus 로고    scopus 로고
    • Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors
    • Abramsson A., Lindblom P., Betsholtz C. Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors. J. Clin. Invest. 2003, 112:1142-1151.
    • (2003) J. Clin. Invest. , vol.112 , pp. 1142-1151
    • Abramsson, A.1    Lindblom, P.2    Betsholtz, C.3
  • 12
    • 26944437515 scopus 로고    scopus 로고
    • PDGFRbeta+perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival
    • Song S., Ewald A.J., Stallcup W., Werb Z., Bergers G. PDGFRbeta+perivascular progenitor cells in tumours regulate pericyte differentiation and vascular survival. Nat. Cell Biol. 2005, 7:870-879.
    • (2005) Nat. Cell Biol. , vol.7 , pp. 870-879
    • Song, S.1    Ewald, A.J.2    Stallcup, W.3    Werb, Z.4    Bergers, G.5
  • 13
    • 9244227134 scopus 로고    scopus 로고
    • Stromal fibroblasts in cancer initiation and progression
    • Bhowmick N.A., Neilson E.G., Moses H.L. Stromal fibroblasts in cancer initiation and progression. Nature 2004, 432:332-337.
    • (2004) Nature , vol.432 , pp. 332-337
    • Bhowmick, N.A.1    Neilson, E.G.2    Moses, H.L.3
  • 14
    • 66149123318 scopus 로고    scopus 로고
    • Notch signaling in bulge stem cells is not required for selection of hair follicle fate
    • Demehri S., Kopan R. Notch signaling in bulge stem cells is not required for selection of hair follicle fate. Development 2009, 136:891-896.
    • (2009) Development , vol.136 , pp. 891-896
    • Demehri, S.1    Kopan, R.2
  • 18
    • 28944432805 scopus 로고    scopus 로고
    • Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis
    • Hill R., Song Y., Cardiff R.D., Van Dyke T. Selective evolution of stromal mesenchyme with p53 loss in response to epithelial tumorigenesis. Cell 2005, 123:1001-1011.
    • (2005) Cell , vol.123 , pp. 1001-1011
    • Hill, R.1    Song, Y.2    Cardiff, R.D.3    Van Dyke, T.4
  • 21
    • 0036643778 scopus 로고    scopus 로고
    • Peripheral lymph node stromal cells can promote growth and tumorigenicity of breast carcinoma cells through the release of IGF-I and EGF
    • LeBedis C., Chen K., Fallavollita L., Boutros T., Brodt P. Peripheral lymph node stromal cells can promote growth and tumorigenicity of breast carcinoma cells through the release of IGF-I and EGF. Int. J. Cancer 2002, 100:2-8.
    • (2002) Int. J. Cancer , vol.100 , pp. 2-8
    • LeBedis, C.1    Chen, K.2    Fallavollita, L.3    Boutros, T.4    Brodt, P.5
  • 23
    • 4444261024 scopus 로고    scopus 로고
    • Angiogenesis gene expression profiling in xenograft models to study cellular interactions
    • Thijssen V.L., Brandwijk R.J., Dings R.P., Griffioen A.W. Angiogenesis gene expression profiling in xenograft models to study cellular interactions. Exp. Cell Res. 2004, 299:286-293.
    • (2004) Exp. Cell Res. , vol.299 , pp. 286-293
    • Thijssen, V.L.1    Brandwijk, R.J.2    Dings, R.P.3    Griffioen, A.W.4
  • 28
    • 38849202330 scopus 로고    scopus 로고
    • Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting
    • Pietras K., Pahler J., Bergers G., Hanahan D. Functions of paracrine PDGF signaling in the proangiogenic tumor stroma revealed by pharmacological targeting. PLoS Med. 2008, 5:e19.
    • (2008) PLoS Med. , vol.5
    • Pietras, K.1    Pahler, J.2    Bergers, G.3    Hanahan, D.4
  • 30
    • 18844428327 scopus 로고    scopus 로고
    • Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion
    • Orimo A., Gupta P.B., Sgroi D.C., Arenzana-Seisdedos F., Delaunay T., Naeem R., Carey V.J., Richardson A.L., Weinberg R.A. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 2005, 121:335-348.
    • (2005) Cell , vol.121 , pp. 335-348
    • Orimo, A.1    Gupta, P.B.2    Sgroi, D.C.3    Arenzana-Seisdedos, F.4    Delaunay, T.5    Naeem, R.6    Carey, V.J.7    Richardson, A.L.8    Weinberg, R.A.9
  • 32
    • 39649096965 scopus 로고    scopus 로고
    • The effects of tumor-derived platelet-derived growth factor on vascular morphology and function in vivo revealed by susceptibility MRI
    • Robinson S.P., Ludwig C., Paulsson J., Ostman A. The effects of tumor-derived platelet-derived growth factor on vascular morphology and function in vivo revealed by susceptibility MRI. Int. J. Cancer 2008, 122:1548-1556.
    • (2008) Int. J. Cancer , vol.122 , pp. 1548-1556
    • Robinson, S.P.1    Ludwig, C.2    Paulsson, J.3    Ostman, A.4
  • 33
    • 34547662268 scopus 로고    scopus 로고
    • Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content
    • McCarty M.F., Somcio R.J., Stoeltzing O., Wey J., Fan F., Liu W., Bucana C., Ellis L.M. Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content. J. Clin. Invest. 2007, 117:2114-2122.
    • (2007) J. Clin. Invest. , vol.117 , pp. 2114-2122
    • McCarty, M.F.1    Somcio, R.J.2    Stoeltzing, O.3    Wey, J.4    Fan, F.5    Liu, W.6    Bucana, C.7    Ellis, L.M.8
  • 34
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • Joyce J.A., Pollard J.W. Microenvironmental regulation of metastasis. Nat. Rev. Cancer 2009, 9:239-252.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 39
    • 57849106330 scopus 로고    scopus 로고
    • PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment
    • Crawford Y., Kasman I., Yu L., Zhong C., Wu X., Modrusan Z., Kaminker J., Ferrara N. PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment. Cancer Cell 2009, 15:21-34.
    • (2009) Cancer Cell , vol.15 , pp. 21-34
    • Crawford, Y.1    Kasman, I.2    Yu, L.3    Zhong, C.4    Wu, X.5    Modrusan, Z.6    Kaminker, J.7    Ferrara, N.8
  • 41
    • 0035297541 scopus 로고    scopus 로고
    • Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors
    • Pietras K., Ostman A., Sjoquist M., Buchdunger E., Reed R.K., Heldin C.H., Rubin K. Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors. Cancer Res. 2001, 61:2929-2934.
    • (2001) Cancer Res. , vol.61 , pp. 2929-2934
    • Pietras, K.1    Ostman, A.2    Sjoquist, M.3    Buchdunger, E.4    Reed, R.K.5    Heldin, C.H.6    Rubin, K.7
  • 45
    • 72849125358 scopus 로고    scopus 로고
    • Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice
    • Santos A.M., Jung J., Aziz N., Kissil J.L., Pure E. Targeting fibroblast activation protein inhibits tumor stromagenesis and growth in mice. J. Clin. Invest. 2009, 119:3613-3625.
    • (2009) J. Clin. Invest. , vol.119 , pp. 3613-3625
    • Santos, A.M.1    Jung, J.2    Aziz, N.3    Kissil, J.L.4    Pure, E.5
  • 46
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • Bergers G., Song S., Meyer-Morse N., Bergsland E., Hanahan D. Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J. Clin. Invest. 2003, 111:1287-1295.
    • (2003) J. Clin. Invest. , vol.111 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3    Bergsland, E.4    Hanahan, D.5
  • 47
    • 1442290142 scopus 로고    scopus 로고
    • Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms
    • Erber R., Thurnher A., Katsen A.D., Groth G., Kerger H., Hammes H.P., Menger M.D., Ullrich A., Vajkoczy P. Combined inhibition of VEGF and PDGF signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms. FASEB J. 2004, 18:338-340.
    • (2004) FASEB J. , vol.18 , pp. 338-340
    • Erber, R.1    Thurnher, A.2    Katsen, A.D.3    Groth, G.4    Kerger, H.5    Hammes, H.P.6    Menger, M.D.7    Ullrich, A.8    Vajkoczy, P.9
  • 48
    • 14644446018 scopus 로고    scopus 로고
    • A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer
    • Pietras K., Hanahan D. A multitargeted, metronomic, and maximum-tolerated dose "chemo-switch" regimen is antiangiogenic, producing objective responses and survival benefit in a mouse model of cancer. J. Clin. Oncol. 2005, 23:939-952.
    • (2005) J. Clin. Oncol. , vol.23 , pp. 939-952
    • Pietras, K.1    Hanahan, D.2
  • 54
    • 36249021985 scopus 로고    scopus 로고
    • Identification of a subset of pericytes that respond to combination therapy targeting PDGF and VEGF signaling
    • Hasumi Y., Klosowska-Wardega A., Furuhashi M., Ostman A., Heldin C.H., Hellberg C. Identification of a subset of pericytes that respond to combination therapy targeting PDGF and VEGF signaling. Int. J. Cancer 2007, 121:2606-2614.
    • (2007) Int. J. Cancer , vol.121 , pp. 2606-2614
    • Hasumi, Y.1    Klosowska-Wardega, A.2    Furuhashi, M.3    Ostman, A.4    Heldin, C.H.5    Hellberg, C.6
  • 55
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers G., Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat. Rev. Cancer 2008, 8:592-603.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 58
    • 40349088993 scopus 로고    scopus 로고
    • High levels of HIF-2alpha highlight an immature neural crest-like neuroblastoma cell cohort located in a perivascular niche
    • Pietras A., Gisselsson D., Ora I., Noguera R., Beckman S., Navarro S., Pahlman S. High levels of HIF-2alpha highlight an immature neural crest-like neuroblastoma cell cohort located in a perivascular niche. J. Pathol. 2008, 214:482-488.
    • (2008) J. Pathol. , vol.214 , pp. 482-488
    • Pietras, A.1    Gisselsson, D.2    Ora, I.3    Noguera, R.4    Beckman, S.5    Navarro, S.6    Pahlman, S.7
  • 61
    • 76349096670 scopus 로고    scopus 로고
    • Cancer Associated Fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-KB-dependent manner
    • Erez N., Truitt M., Olson P., Hanahan D. Cancer Associated Fibroblasts are activated in incipient neoplasia to orchestrate tumor-promoting inflammation in an NF-KB-dependent manner. Cancer Cell 2010, 17(2):135-147.
    • (2010) Cancer Cell , vol.17 , Issue.2 , pp. 135-147
    • Erez, N.1    Truitt, M.2    Olson, P.3    Hanahan, D.4
  • 63
    • 70949103794 scopus 로고    scopus 로고
    • Cancer associated fibroblasts promote tumor growth and metastasis by modulating the tumor immune microenvironment in a 4T1 murine breast cancer model
    • Liao D., Luo Y., Markowitz D., Xiang R., Reisfeld R.A. Cancer associated fibroblasts promote tumor growth and metastasis by modulating the tumor immune microenvironment in a 4T1 murine breast cancer model. PLoS ONE 2009, 4:e7965.
    • (2009) PLoS ONE , vol.4
    • Liao, D.1    Luo, Y.2    Markowitz, D.3    Xiang, R.4    Reisfeld, R.A.5
  • 68
    • 57849100048 scopus 로고    scopus 로고
    • Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche
    • Erler J.T., Bennewith K.L., Cox T.R., Lang G., Bird D., Koong A., Le Q.T., Giaccia A.J. Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell 2009, 15:35-44.
    • (2009) Cancer Cell , vol.15 , pp. 35-44
    • Erler, J.T.1    Bennewith, K.L.2    Cox, T.R.3    Lang, G.4    Bird, D.5    Koong, A.6    Le, Q.T.7    Giaccia, A.J.8
  • 72
    • 57149110826 scopus 로고    scopus 로고
    • The Human Protein Atlas-a tool for pathology
    • Ponten F., Jirstrom K., Uhlen M. The Human Protein Atlas-a tool for pathology. J. Pathol. 2008, 216:387-393.
    • (2008) J. Pathol. , vol.216 , pp. 387-393
    • Ponten, F.1    Jirstrom, K.2    Uhlen, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.