The Tumor Microenvironment Represses T Cell Mitochondrial Biogenesis to Drive Intratumoral T Cell Metabolic Insufficiency and Dysfunction

Immunity

Volumn 45, Issue 2, 2016, Pages 374-388

  Scharping, Nicole E ^a,b   Menk, Ashley V ^a   Moreci, Rebecca S ^a   Whetstone, Ryan D ^a,b   Dadey, Rebekah E ^a,b   Watkins, Simon C ^b   Ferris, Robert L ^a,b   Delgoffe, Greg M ^a,b  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN KINASE B; ONCOPROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PPARGC1A PROTEIN, MOUSE;

AEROBIC METABOLISM; ANIMAL EXPERIMENT; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL ISOLATION; EFFECTOR CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; METABOLIC CAPACITY; MITOCHONDRIAL BIOGENESIS; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TUMOR ASSOCIATED LEUKOCYTE; TUMOR MICROENVIRONMENT; UPREGULATION; ANIMAL; C57BL MOUSE; COLON TUMOR; EXPERIMENTAL NEOPLASM; GENETICS; IMMUNOLOGY; METABOLISM; MITOCHONDRION; OXIDATIVE STRESS; TRANSGENIC MOUSE; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CELLULAR REPROGRAMMING; COLONIC NEOPLASMS; HUMANS; LYMPHOCYTES, TUMOR-INFILTRATING; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOCHONDRIA; NEOPLASMS, EXPERIMENTAL; ONCOGENE PROTEIN V-AKT; OXIDATIVE STRESS; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA; PPAR GAMMA; SIGNAL TRANSDUCTION; T-LYMPHOCYTES; TUMOR MICROENVIRONMENT;

EID: 84997766028     PISSN: 10747613     EISSN: 10974180     Source Type: Journal    
DOI: 10.1016/j.immuni.2016.07.009     Document Type: Article

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