-
1
-
-
61449254259
-
Increased insulin demand promotes while pioglitazone prevents pancreatic beta cell apoptosis in Wfs1 knockout mice
-
Akiyama M, Hatanaka M, Ohta Y, Ueda K, Yanai A, Uehara Y, Tanabe K, Tsuru M, Miyazaki M, Saeki S, et al. 2009 Increased insulin demand promotes while pioglitazone prevents pancreatic beta cell apoptosis in Wfs1 knockout mice. Diabetologia 52 653-663. (doi:10.1007/ s00125-009-1270-6)
-
(2009)
Diabetologia
, vol.52
, pp. 653-663
-
-
Akiyama, M.1
Hatanaka, M.2
Ohta, Y.3
Ueda, K.4
Yanai, A.5
Uehara, Y.6
Tanabe, K.7
Tsuru, M.8
Miyazaki, M.9
Saeki, S.10
-
2
-
-
77952093535
-
Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis
-
Allagnat F, Christulia F, Ortis F, Pirot P, Lortz S, Lenzen S, Eizirik DL & Cardozo AK 2010 Sustained production of spliced X-box binding protein 1 (XBP1) induces pancreatic beta cell dysfunction and apoptosis. Diabetologia 53 1120-1130. (doi:10.1007/s00125-010-1699-7)
-
(2010)
Diabetologia
, vol.53
, pp. 1120-1130
-
-
Allagnat, F.1
Christulia, F.2
Ortis, F.3
Pirot, P.4
Lortz, S.5
Lenzen, S.6
Eizirik, D.L.7
Cardozo, A.K.8
-
3
-
-
78651303018
-
Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to beta-cell apoptosis
-
Allagnat F, Cunha D, Moore F, Vanderwinden JM, Eizirik DL & Cardozo AK 2011 Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to beta-cell apoptosis. Cell Death and Differentiation 18 328-337. (doi:10.1038/ cdd.2010.105)
-
(2011)
Cell Death and Differentiation
, vol.18
, pp. 328-337
-
-
Allagnat, F.1
Cunha, D.2
Moore, F.3
Vanderwinden, J.M.4
Eizirik, D.L.5
Cardozo, A.K.6
-
4
-
-
84870988528
-
C/EBP homologous protein contributes to cytokine-induced proinflammatory responses and apoptosis in beta-cells
-
Allagnat F, Fukaya M, Nogueira TC, Delaroche D, Welsh N, Marselli L, Marchetti P, Haefliger JA, Eizirik DL & Cardozo AK 2012 C/EBP homologous protein contributes to cytokine-induced proinflammatory responses and apoptosis in beta-cells. Cell Death and Differentiation 19 1836-1846. (doi:10.1038/cdd.2012.67)
-
(2012)
Cell Death and Differentiation
, vol.19
, pp. 1836-1846
-
-
Allagnat, F.1
Fukaya, M.2
Nogueira, T.C.3
Delaroche, D.4
Welsh, N.5
Marselli, L.6
Marchetti, P.7
Haefliger, J.A.8
Eizirik, D.L.9
Cardozo, A.K.10
-
5
-
-
84903384321
-
Resveratrol attenuates hepatic steatosis in high-fat fed mice by decreasing lipogenesis and inflammation
-
Andrade JM, Paraiso AF, de Oliveira MV, Martins AM, Neto JF, Guimaraes AL, de Paula AM, Qureshi M & Santos SH 2014 Resveratrol attenuates hepatic steatosis in high-fat fed mice by decreasing lipogenesis and inflammation. Nutrition 30 915-919. (doi:10.1016/j.nut.2013.11.016)
-
(2014)
Nutrition
, vol.30
, pp. 915-919
-
-
Andrade, J.M.1
Paraiso, A.F.2
de Oliveira, M.V.3
Martins, A.M.4
Neto, J.F.5
Guimaraes, A.L.6
de Paula, A.M.7
Qureshi, M.8
Santos, S.H.9
-
6
-
-
0035971572
-
Function and regulation of AP-1 subunits in skin physiology and pathology
-
Angel P, Szabowski A & Schorpp-Kistner M 2001 Function and regulation of AP-1 subunits in skin physiology and pathology. Oncogene 20 2413-2423. (doi:10.1038/sj.onc.1204380)
-
(2001)
Oncogene
, vol.20
, pp. 2413-2423
-
-
Angel, P.1
Szabowski, A.2
Schorpp-Kistner, M.3
-
7
-
-
55649099025
-
The role of CHOP messenger RNA expression in the link between oxidative stress and apoptosis
-
Ariyama Y, Tanaka Y, Shimizu H, Shimomura K, Okada S, Saito T, Yamada E, Oyadomari S & Mori M 2008 The role of CHOP messenger RNA expression in the link between oxidative stress and apoptosis. Metabolism 57 1625-1635. (doi:10.1016/j. metabol.2008.06.019)
-
(2008)
Metabolism
, vol.57
, pp. 1625-1635
-
-
Ariyama, Y.1
Tanaka, Y.2
Shimizu, H.3
Shimomura, K.4
Okada, S.5
Saito, T.6
Yamada, E.7
Oyadomari, S.8
Mori, M.9
-
8
-
-
84905094281
-
A randomized clinical trial study: Anti-oxidant, anti-hyperglycemic and anti-hyperlipidemic effects of olibanum gum in type 2 diabetic patients
-
Azadmehr A, Ziaee A, Ghanei L, Fallah Huseini H, Hajiaghaee R, Tavakoli-Far B & Kordafshari G 2014 A randomized clinical trial study: anti-oxidant, anti-hyperglycemic and anti-hyperlipidemic effects of olibanum gum in type 2 diabetic patients. Iranian Journal of Pharmaceutical Research 13 1003-1009.
-
(2014)
Iranian Journal of Pharmaceutical Research
, vol.13
, pp. 1003-1009
-
-
Azadmehr, A.1
Ziaee, A.2
Ghanei, L.3
Fallah Huseini, H.4
Hajiaghaee, R.5
Tavakoli-Far, B.6
Kordafshari, G.7
-
9
-
-
67649450485
-
Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells
-
Back SH, Scheuner D, Han J, Song B, Ribick M, Wang J, Gildersleeve RD, Pennathur S & Kaufman RJ 2009 Translation attenuation through eIF2alpha phosphorylation prevents oxidative stress and maintains the differentiated state in beta cells. Cell Metabolism 10 13-26. (doi:10.1016/j.cmet.2009.06.002)
-
(2009)
Cell Metabolism
, vol.10
, pp. 13-26
-
-
Back, S.H.1
Scheuner, D.2
Han, J.3
Song, B.4
Ribick, M.5
Wang, J.6
Gildersleeve, R.D.7
Pennathur, S.8
Kaufman, R.J.9
-
10
-
-
0035054076
-
The stress protein BiP is overexpressed and is a major B and T cell target in rheumatoid arthritis
-
Blass S, Union A, Raymackers J, Schumann F, Ungethum U, Muller-Steinbach S, De Keyser F, Engel JM & Burmester GR 2001 The stress protein BiP is overexpressed and is a major B and T cell target in rheumatoid arthritis. Arthritis and Rheumatism 44 761-771.
-
(2001)
Arthritis and Rheumatism
, vol.44
, pp. 761-771
-
-
Blass, S.1
Union, A.2
Raymackers, J.3
Schumann, F.4
Ungethum, U.5
Muller-Steinbach, S.6
De Keyser, F.7
Engel, J.M.8
Burmester, G.R.9
-
11
-
-
0035152487
-
Cell-permeable peptide inhibitors of JNK: Novel blockers of beta-cell death
-
Bonny C, Oberson A, Negri S, Sauser C & Schorderet DF 2001 Cell-permeable peptide inhibitors of JNK: novel blockers of beta-cell death. Diabetes 50 77-82. (doi:10.2337/diabetes.50.1.77)
-
(2001)
Diabetes
, vol.50
, pp. 77-82
-
-
Bonny, C.1
Oberson, A.2
Negri, S.3
Sauser, C.4
Schorderet, D.F.5
-
12
-
-
0036105204
-
Regulation of ER stress proteins by valproate: Therapeutic implications
-
Bown CD, Wang JF, Chen B & Young LT 2002 Regulation of ER stress proteins by valproate: therapeutic implications. Bipolar Disorders 4 145-151. (doi:10.1034/j.1399-5618.2002.t01-1-40201.x)
-
(2002)
Bipolar Disorders
, vol.4
, pp. 145-151
-
-
Bown, C.D.1
Wang, J.F.2
Chen, B.3
Young, L.T.4
-
13
-
-
13644256191
-
A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress
-
Boyce M, Bryant KF, Jousse C, Long K, Harding HP, Scheuner D, Kaufman RJ, Ma D, Coen DM, Ron D, et al. 2005 A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. Science 307 935-939. (doi:10.1126/science.1101902)
-
(2005)
Science
, vol.307
, pp. 935-939
-
-
Boyce, M.1
Bryant, K.F.2
Jousse, C.3
Long, K.4
Harding, H.P.5
Scheuner, D.6
Kaufman, R.J.7
Ma, D.8
Coen, D.M.9
Ron, D.10
-
14
-
-
84959066070
-
ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes
-
Brozzi F & Eizirik DL 2016 ER stress and the decline and fall of pancreatic beta cells in type 1 diabetes. Upsala Journal of Medical Sciences 1-7. (doi:10.3109/03009734.2015.1135217)
-
(2016)
Upsala Journal of Medical Sciences
, pp. 1-7
-
-
Brozzi, F.1
Eizirik, D.L.2
-
15
-
-
84905397729
-
A combined 'omics' approach identifies N-Myc interactor as a novel cytokine-induced regulator of IRE1 protein and c-Jun N-terminal kinase in pancreatic beta cells
-
Brozzi F, Gerlo S, Grieco FA, Nardelli TR, Lievens S, Gysemans C, Marselli L, Marchetti P, Mathieu C, Tavernier J, et al. 2014 A combined 'omics' approach identifies N-Myc interactor as a novel cytokine-induced regulator of IRE1 protein and c-Jun N-terminal kinase in pancreatic beta cells. Journal of Biological Chemistry 289 20677-20693. (doi:10.1074/jbc.M114.568808)
-
(2014)
Journal of Biological Chemistry
, vol.289
, pp. 20677-20693
-
-
Brozzi, F.1
Gerlo, S.2
Grieco, F.A.3
Nardelli, T.R.4
Lievens, S.5
Gysemans, C.6
Marselli, L.7
Marchetti, P.8
Mathieu, C.9
Tavernier, J.10
-
16
-
-
84942195054
-
Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms
-
Brozzi F, Nardelli TR, Lopes M, Millard I, Barthson J, Igoillo-Esteve M, Grieco FA, Villate O, Oliveira JM, Casimir M, et al. 2015 Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms. Diabetologia 58 2307-2316. (doi:10.1007/s00125-015-3669-6)
-
(2015)
Diabetologia
, vol.58
, pp. 2307-2316
-
-
Brozzi, F.1
Nardelli, T.R.2
Lopes, M.3
Millard, I.4
Barthson, J.5
Igoillo-Esteve, M.6
Grieco, F.A.7
Villate, O.8
Oliveira, J.M.9
Casimir, M.10
-
17
-
-
84903795970
-
Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease
-
Cao SS & Kaufman RJ 2014 Endoplasmic reticulum stress and oxidative stress in cell fate decision and human disease. Antioxidants & Redox Signaling 21 396-413. (doi:10.1089/ars.2014.5851)
-
(2014)
Antioxidants & Redox Signaling
, vol.21
, pp. 396-413
-
-
Cao, S.S.1
Kaufman, R.J.2
-
18
-
-
19944432792
-
Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells
-
Cardozo AK, Ortis F, Storling J, Feng YM, Rasschaert J, Tonnesen M, Van Eylen F, Mandrup-Poulsen T, Herchuelz A & Eizirik DL 2005 Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic beta-cells. Diabetes 54 452-461. (doi:10.2337/diabetes.54.2.452)
-
(2005)
Diabetes
, vol.54
, pp. 452-461
-
-
Cardozo, A.K.1
Ortis, F.2
Storling, J.3
Feng, Y.M.4
Rasschaert, J.5
Tonnesen, M.6
Van Eylen, F.7
Mandrup-Poulsen, T.8
Herchuelz, A.9
Eizirik, D.L.10
-
19
-
-
79959715318
-
Differential regulation of adaptive and apoptotic unfolded protein response signalling by cytokine-induced nitric oxide production in mouse pancreatic beta cells
-
Chan JY, Cooney GJ, Biden TJ & Laybutt DR 2011 Differential regulation of adaptive and apoptotic unfolded protein response signalling by cytokine-induced nitric oxide production in mouse pancreatic beta cells. Diabetologia 54 1766-1776. (doi:10.1007/s00125-011-2139-z)
-
(2011)
Diabetologia
, vol.54
, pp. 1766-1776
-
-
Chan, J.Y.1
Cooney, G.J.2
Biden, T.J.3
Laybutt, D.R.4
-
20
-
-
84867571170
-
Cross-talk between the unfolded protein response and nuclear factor-kappaB signalling pathways regulates cytokine-mediated beta cell death in MIN6 cells and isolated mouse islets
-
Chan JY, Biden TJ & Laybutt DR 2012 Cross-talk between the unfolded protein response and nuclear factor-kappaB signalling pathways regulates cytokine-mediated beta cell death in MIN6 cells and isolated mouse islets. Diabetologia 55 2999-3009. (doi:10.1007/ s00125-012-2657-3)
-
(2012)
Diabetologia
, vol.55
, pp. 2999-3009
-
-
Chan, J.Y.1
Biden, T.J.2
Laybutt, D.R.3
-
21
-
-
84905190172
-
A molecular web: Endoplasmic reticulum stress, inflammation, and oxidative stress
-
Chaudhari N, Talwar P, Parimisetty A, Lefebvre d'Hellencourt C & Ravanan P 2014 A molecular web: endoplasmic reticulum stress, inflammation, and oxidative stress. Frontiers in Cellular Neuroscience 8 213. (doi:10.3389/fncel.2014.00213)
-
(2014)
Frontiers in Cellular Neuroscience
, vol.8
, pp. 213
-
-
Chaudhari, N.1
Talwar, P.2
Parimisetty, A.3
Lefebvre d'Hellencourt, C.4
Ravanan, P.5
-
22
-
-
84892999542
-
Valproic acid: A new candidate of therapeutic application for the acute central nervous system injuries
-
Chen S, Wu H, Klebe D, Hong Y & Zhang J 2014 Valproic acid: a new candidate of therapeutic application for the acute central nervous system injuries. Neurochemical Research 39 1621-1633. (doi:10.1007/ s11064-014-1241-2)
-
(2014)
Neurochemical Research
, vol.39
, pp. 1621-1633
-
-
Chen, S.1
Wu, H.2
Klebe, D.3
Hong, Y.4
Zhang, J.5
-
23
-
-
44949217361
-
A chemical chaperone 4-PBA ameliorates palmitateinduced inhibition of glucose-stimulated insulin secretion (GSIS)
-
Choi SE, Lee YJ, Jang HJ, Lee KW, Kim YS, Jun HS, Kang SS, Chun J & Kang Y 2008 A chemical chaperone 4-PBA ameliorates palmitateinduced inhibition of glucose-stimulated insulin secretion (GSIS). Archives of Biochemistry and Biophysics 475 109-114. (doi:10.1016/j. abb.2008.04.015)
-
(2008)
Archives of Biochemistry and Biophysics
, vol.475
, pp. 109-114
-
-
Choi, S.E.1
Lee, Y.J.2
Jang, H.J.3
Lee, K.W.4
Kim, Y.S.5
Jun, H.S.6
Kang, S.S.7
Chun, J.8
Kang, Y.9
-
25
-
-
33644749322
-
Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: Many differences, few similarities
-
Cnop M, Welsh N, Jonas JC, Jorns A, Lenzen S & Eizirik DL 2005 Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities. Diabetes 54 (Supplement 2) S97-S107.
-
(2005)
Diabetes
, vol.54
, pp. S97-S107
-
-
Cnop, M.1
Welsh, N.2
Jonas, J.C.3
Jorns, A.4
Lenzen, S.5
Eizirik, D.L.6
-
26
-
-
33947510911
-
Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis
-
Cnop M, Ladriere L, Hekerman P, Ortis F, Cardozo AK, Dogusan Z, Flamez D, Boyce M, Yuan J & Eizirik DL 2007 Selective inhibition of eukaryotic translation initiation factor 2 alpha dephosphorylation potentiates fatty acid-induced endoplasmic reticulum stress and causes pancreatic beta-cell dysfunction and apoptosis. Journal of Biological Chemistry 282 3989-3997. (doi:10.1074/jbc.M607627200)
-
(2007)
Journal of Biological Chemistry
, vol.282
, pp. 3989-3997
-
-
Cnop, M.1
Ladriere, L.2
Hekerman, P.3
Ortis, F.4
Cardozo, A.K.5
Dogusan, Z.6
Flamez, D.7
Boyce, M.8
Yuan, J.9
Eizirik, D.L.10
-
27
-
-
77957302786
-
Causes and cures for endoplasmic reticulum stress in lipotoxic betacell dysfunction
-
Cnop M, Ladriere L, Igoillo-Esteve M, Moura RF & Cunha DA 2010 Causes and cures for endoplasmic reticulum stress in lipotoxic betacell dysfunction. Diabetes, Obesity and Metabolism 12 (Supplement 2) 76-82. (doi:10.1111/j.1463-1326.2010.01279.x)
-
(2010)
Diabetes, Obesity and Metabolism
, vol.12
, pp. 76-82
-
-
Cnop, M.1
Ladriere, L.2
Igoillo-Esteve, M.3
Moura, R.F.4
Cunha, D.A.5
-
28
-
-
45749104374
-
Seven mutations in the human insulin gene linked to permanent neonatal/ infancy-onset diabetes mellitus
-
Colombo C, Porzio O, Liu M, Massa O, Vasta M, Salardi S, Beccaria L, Monciotti C, Toni S, Pedersen O, et al. 2008 Seven mutations in the human insulin gene linked to permanent neonatal/ infancy-onset diabetes mellitus. Journal of Clinical Investigation 118 2148-2156. (doi:10.1172/JCI33777)
-
(2008)
Journal of Clinical Investigation
, vol.118
, pp. 2148-2156
-
-
Colombo, C.1
Porzio, O.2
Liu, M.3
Massa, O.4
Vasta, M.5
Salardi, S.6
Beccaria, L.7
Monciotti, C.8
Toni, S.9
Pedersen, O.10
-
29
-
-
84897133645
-
Macrophage contact dependent and independent TLR4 mechanisms induce beta-cell dysfunction and apoptosis in a mouse model of type 2 diabetes
-
Cucak H, Mayer C, Tonnesen M, Thomsen LH, Grunnet LG & Rosendahl A 2014 Macrophage contact dependent and independent TLR4 mechanisms induce beta-cell dysfunction and apoptosis in a mouse model of type 2 diabetes. PLoS ONE 9 e90685. (doi:10.1371/ journal.pone.0090685)
-
(2014)
PLoS ONE
, vol.9
-
-
Cucak, H.1
Mayer, C.2
Tonnesen, M.3
Thomsen, L.H.4
Grunnet, L.G.5
Rosendahl, A.6
-
30
-
-
57649171080
-
Regulation of interleukin-8 gene at a distinct site of its promoter by CCAAT enhancer-binding protein homologous protein in prostaglandin E2-treated human T cells
-
Cucinotta M, Visalli M, Aguennouz M, Valenti A, Loddo S, Altucci L & Teti D 2008 Regulation of interleukin-8 gene at a distinct site of its promoter by CCAAT enhancer-binding protein homologous protein in prostaglandin E2-treated human T cells. Journal of Biological Chemistry 283 29760-29769. (doi:10.1074/jbc.M803145200)
-
(2008)
Journal of Biological Chemistry
, vol.283
, pp. 29760-29769
-
-
Cucinotta, M.1
Visalli, M.2
Aguennouz, M.3
Valenti, A.4
Loddo, S.5
Altucci, L.6
Teti, D.7
-
31
-
-
29244462498
-
Coordination of ER and oxidative stress signaling: The PERK/Nrf2 signaling pathway
-
Cullinan SB & Diehl JA 2006 Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathway. International Journal of Biochemistry and Cell Biology 38 317-332. (doi:10.1016/j. biocel.2005.09.018)
-
(2006)
International Journal of Biochemistry and Cell Biology
, vol.38
, pp. 317-332
-
-
Cullinan, S.B.1
Diehl, J.A.2
-
32
-
-
49649084031
-
Initiation and execution of lipotoxic ER stress in pancreatic beta-cells
-
Cunha DA, Hekerman P, Ladriere L, Bazarra-Castro A, Ortis F, Wakeham MC, Moore F, Rasschaert J, Cardozo AK, Bellomo E, et al. 2008 Initiation and execution of lipotoxic ER stress in pancreatic beta-cells. Journal of Cell Science 121 2308-2318. (doi:10.1242/ jcs.026062)
-
(2008)
Journal of Cell Science
, vol.121
, pp. 2308-2318
-
-
Cunha, D.A.1
Hekerman, P.2
Ladriere, L.3
Bazarra-Castro, A.4
Ortis, F.5
Wakeham, M.C.6
Moore, F.7
Rasschaert, J.8
Cardozo, A.K.9
Bellomo, E.10
-
33
-
-
73249116246
-
Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB
-
Cunha DA, Ladriere L, Ortis F, Igoillo-Esteve M, Gurzov EN, Lupi R, Marchetti P, Eizirik DL & Cnop M 2009 Glucagon-like peptide-1 agonists protect pancreatic beta-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB. Diabetes 58 2851-2862. (doi:10.2337/db09-0685)
-
(2009)
Diabetes
, vol.58
, pp. 2851-2862
-
-
Cunha, D.A.1
Ladriere, L.2
Ortis, F.3
Igoillo-Esteve, M.4
Gurzov, E.N.5
Lupi, R.6
Marchetti, P.7
Eizirik, D.L.8
Cnop, M.9
-
34
-
-
0034644522
-
Signal transduction by the JNK group of MAP kinases
-
Davis RJ 2000 Signal transduction by the JNK group of MAP kinases. Cell 103 239-252. (doi:10.1016/S0092-8674(00)00116-1)
-
(2000)
Cell
, vol.103
, pp. 239-252
-
-
Davis, R.J.1
-
35
-
-
84959909719
-
Comparative review of dipeptidyl peptidase-4 inhibitors and sulphonylureas
-
Deacon CF & Lebovitz HE 2016 Comparative review of dipeptidyl peptidase-4 inhibitors and sulphonylureas. Diabetes, Obesity and Metabolism 18 333-347. (doi:10.1111/dom.12610)
-
(2016)
Diabetes, Obesity and Metabolism
, vol.18
, pp. 333-347
-
-
Deacon, C.F.1
Lebovitz, H.E.2
-
36
-
-
0034425698
-
EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome
-
Delepine M, Nicolino M, Barrett T, Golamaully M, Lathrop GM & Julier C 2000 EIF2AK3, encoding translation initiation factor 2-alpha kinase 3, is mutated in patients with Wolcott-Rallison syndrome. Nature Genetics 25 406-409. (doi:10.1038/78085)
-
(2000)
Nature Genetics
, vol.25
, pp. 406-409
-
-
Delepine, M.1
Nicolino, M.2
Barrett, T.3
Golamaully, M.4
Lathrop, G.M.5
Julier, C.6
-
37
-
-
8644282751
-
Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2
-
Deng J, Lu PD, Zhang Y, Scheuner D, Kaufman RJ, Sonenberg N, Harding HP & Ron D 2004 Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Molecular and Cellular Biology 24 10161-10168. (doi:10.1128/MCB.24.23.10161-10168.2004)
-
(2004)
Molecular and Cellular Biology
, vol.24
, pp. 10161-10168
-
-
Deng, J.1
Lu, P.D.2
Zhang, Y.3
Scheuner, D.4
Kaufman, R.J.5
Sonenberg, N.6
Harding, H.P.7
Ron, D.8
-
38
-
-
84892393658
-
The stress-regulated transcription factor CHOP promotes hepatic inflammatory gene expression, fibrosis, and oncogenesis
-
DeZwaan-McCabe D, Riordan JD, Arensdorf AM, Icardi MS, Dupuy AJ & Rutkowski DT 2013 The stress-regulated transcription factor CHOP promotes hepatic inflammatory gene expression, fibrosis, and oncogenesis. PLoS Genetics 9 e1003937. (doi:10.1371/journal. pgen.1003937)
-
(2013)
PLoS Genetics
, vol.9
-
-
DeZwaan-McCabe, D.1
Riordan, J.D.2
Arensdorf, A.M.3
Icardi, M.S.4
Dupuy, A.J.5
Rutkowski, D.T.6
-
39
-
-
54249119561
-
JNK signaling in apoptosis
-
Dhanasekaran DN & Reddy EP 2008 JNK signaling in apoptosis. Oncogene 27 6245-6251. (doi:10.1038/onc.2008.301)
-
(2008)
Oncogene
, vol.27
, pp. 6245-6251
-
-
Dhanasekaran, D.N.1
Reddy, E.P.2
-
40
-
-
0038691972
-
Low-grade systemic inflammation and the development of type 2 diabetes: The atherosclerosis risk in communities study
-
Duncan BB, Schmidt MI, Pankow JS, Ballantyne CM, Couper D, Vigo A, Hoogeveen R, Folsom AR, Heiss G & Atherosclerosis Risk in Communities Study 2003 Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study. Diabetes 52 1799-1805. (doi:10.2337/ diabetes.52.7.1799)
-
(2003)
Diabetes
, vol.52
, pp. 1799-1805
-
-
Duncan, B.B.1
Schmidt, M.I.2
Pankow, J.S.3
Ballantyne, C.M.4
Couper, D.5
Vigo, A.6
Hoogeveen, R.7
Folsom, A.R.8
Heiss, G.9
-
41
-
-
0242691046
-
AP-1: A double-edged sword in tumorigenesis
-
Eferl R & Wagner EF 2003 AP-1: a double-edged sword in tumorigenesis. Nature Reviews Cancer 3 859-868. (doi:10.1038/nrc1209)
-
(2003)
Nature Reviews Cancer
, vol.3
, pp. 859-868
-
-
Eferl, R.1
Wagner, E.F.2
-
42
-
-
84883530920
-
Macrophages and islet inflammation in type 2 diabetes
-
Eguchi K & Manabe I 2013 Macrophages and islet inflammation in type 2 diabetes. Diabetes, Obesity and Metabolism 15 (Supplement 3) 152-158. (doi:10.1111/dom.12168)
-
(2013)
Diabetes, Obesity and Metabolism
, vol.15
, pp. 152-158
-
-
Eguchi, K.1
Manabe, I.2
-
43
-
-
84859449180
-
Saturated fatty acid and TLR signaling link beta cell dysfunction and islet inflammation
-
Eguchi K, Manabe I, Oishi-Tanaka Y, Ohsugi M, Kono N, Ogata F, Yagi N, Ohto U, Kimoto M, Miyake K, et al. 2012 Saturated fatty acid and TLR signaling link beta cell dysfunction and islet inflammation. Cell Metabolism 15 518-533. (doi:10.1016/j.cmet.2012.01.023)
-
(2012)
Cell Metabolism
, vol.15
, pp. 518-533
-
-
Eguchi, K.1
Manabe, I.2
Oishi-Tanaka, Y.3
Ohsugi, M.4
Kono, N.5
Ogata, F.6
Yagi, N.7
Ohto, U.8
Kimoto, M.9
Miyake, K.10
-
44
-
-
0025995444
-
Interleukin-1 beta induces an early decrease in insulin release, (pro)insulin biosynthesis and insulin mRNA in mouse pancreatic islets by a mechanism dependent on gene transcription and protein synthesis
-
Eizirik DL 1991 Interleukin-1 beta induces an early decrease in insulin release, (pro)insulin biosynthesis and insulin mRNA in mouse pancreatic islets by a mechanism dependent on gene transcription and protein synthesis. Autoimmunity 10 107-113. (doi:10.3109/08916939109004814)
-
(1991)
Autoimmunity
, vol.10
, pp. 107-113
-
-
Eizirik, D.L.1
-
45
-
-
0035668779
-
A choice of death-the signaltransduction of immune-mediated beta-cell apoptosis
-
Eizirik DL & Mandrup-Poulsen T 2001 A choice of death-the signaltransduction of immune-mediated beta-cell apoptosis. Diabetologia 44 2115-2133. (doi:10.1007/s001250100021)
-
(2001)
Diabetologia
, vol.44
, pp. 2115-2133
-
-
Eizirik, D.L.1
Mandrup-Poulsen, T.2
-
46
-
-
39149104320
-
The role for endoplasmic reticulum stress in diabetes mellitus
-
Eizirik DL, Cardozo AK & Cnop M 2008 The role for endoplasmic reticulum stress in diabetes mellitus. Endocrine Reviews 29 42-61. (doi:10.1210/er.2007-0015)
-
(2008)
Endocrine Reviews
, vol.29
, pp. 42-61
-
-
Eizirik, D.L.1
Cardozo, A.K.2
Cnop, M.3
-
47
-
-
67649364114
-
The role of inflammation in insulitis and beta-cell loss in type 1 diabetes
-
Eizirik DL, Colli ML & Ortis F 2009 The role of inflammation in insulitis and beta-cell loss in type 1 diabetes. Nature Reviews Endocrinology 5 219-226. (doi:10.1038/nrendo.2009.21)
-
(2009)
Nature Reviews Endocrinology
, vol.5
, pp. 219-226
-
-
Eizirik, D.L.1
Colli, M.L.2
Ortis, F.3
-
48
-
-
33645518035
-
Conditional and specific NF-kappaB blockade protects pancreatic beta cells from diabetogenic agents
-
Eldor R, Yeffet A, Baum K, Doviner V, Amar D, Ben-Neriah Y, Christofori G, Peled A, Carel JC, Boitard C, et al. 2006 Conditional and specific NF-kappaB blockade protects pancreatic beta cells from diabetogenic agents. PNAS 103 5072-5077. (doi:10.1073/ pnas.0508166103)
-
(2006)
PNAS
, vol.103
, pp. 5072-5077
-
-
Eldor, R.1
Yeffet, A.2
Baum, K.3
Doviner, V.4
Amar, D.5
Ben-Neriah, Y.6
Christofori, G.7
Peled, A.8
Carel, J.C.9
Boitard, C.10
-
50
-
-
34249933087
-
Acute nutrient regulation of the unfolded protein response and integrated stress response in cultured rat pancreatic islets
-
Elouil H, Bensellam M, Guiot Y, Vander Mierde D, Pascal SM, Schuit FC & Jonas JC 2007 Acute nutrient regulation of the unfolded protein response and integrated stress response in cultured rat pancreatic islets. Diabetologia 50 1442-1452. (doi:10.1007/s00125-007-0674-4)
-
(2007)
Diabetologia
, vol.50
, pp. 1442-1452
-
-
Elouil, H.1
Bensellam, M.2
Guiot, Y.3
Vander Mierde, D.4
Pascal, S.M.5
Schuit, F.C.6
Jonas, J.C.7
-
51
-
-
28244470819
-
The ER stress pathway involving CHOP is activated in the lungs of LPS-treated mice
-
Endo M, Oyadomari S, Suga M, Mori M & Gotoh T 2005 The ER stress pathway involving CHOP is activated in the lungs of LPS-treated mice. Journal of Biochemistry 138 501-507. (doi:10.1093/jb/mvi143)
-
(2005)
Journal of Biochemistry
, vol.138
, pp. 501-507
-
-
Endo, M.1
Oyadomari, S.2
Suga, M.3
Mori, M.4
Gotoh, T.5
-
52
-
-
33646491144
-
C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation
-
Endo M, Mori M, Akira S & Gotoh T 2006 C/EBP homologous protein (CHOP) is crucial for the induction of caspase-11 and the pathogenesis of lipopolysaccharide-induced inflammation. Journal of Immunology 176 6245-6253. (doi:10.4049/jimmunol.176.10.6245)
-
(2006)
Journal of Immunology
, vol.176
, pp. 6245-6253
-
-
Endo, M.1
Mori, M.2
Akira, S.3
Gotoh, T.4
-
53
-
-
84890076252
-
Restoration of the unfolded protein response in pancreatic beta cells protects mice against type 1 diabetes
-
Engin F, Yermalovich A, Ngyuen T, Hummasti S, Fu W, Eizirik DL, Mathis D & Hotamisligil GS 2013 Restoration of the unfolded protein response in pancreatic beta cells protects mice against type 1 diabetes. Science Translational Medicine 5 211ra156. (doi:10.1126/ scitranslmed.3006534)
-
(2013)
Science Translational Medicine
, vol.5
-
-
Engin, F.1
Yermalovich, A.2
Ngyuen, T.3
Hummasti, S.4
Fu, W.5
Eizirik, D.L.6
Mathis, D.7
Hotamisligil, G.S.8
-
54
-
-
84953204319
-
A20 Inhibits beta-cell apoptosis by multiple mechanisms and predicts residual beta-cell function in type 1 diabetes
-
Fukaya M, Brorsson CA, Meyerovich K, Catrysse L, Delaroche D, Vanzela EC, Ortis F, Beyaert R, Nielsen LB, Andersen ML, et al. 2016 A20 Inhibits beta-cell apoptosis by multiple mechanisms and predicts residual beta-cell function in type 1 diabetes. Molecular Endocrinology 30 48-61. (doi:10.1210/me.2015-1176)
-
(2016)
Molecular Endocrinology
, vol.30
, pp. 48-61
-
-
Fukaya, M.1
Brorsson, C.A.2
Meyerovich, K.3
Catrysse, L.4
Delaroche, D.5
Vanzela, E.C.6
Ortis, F.7
Beyaert, R.8
Nielsen, L.B.9
Andersen, M.L.10
-
56
-
-
84866932320
-
ER stress-induced inflammation: Does it aid or impede disease progression?
-
Garg AD, Kaczmarek A, Krysko O, Vandenabeele P, Krysko DV & Agostinis P 2012 ER stress-induced inflammation: does it aid or impede disease progression? Trends in Molecular Medicine 18 589-598. (doi:10.1016/j.molmed.2012.06.010)
-
(2012)
Trends in Molecular Medicine
, vol.18
, pp. 589-598
-
-
Garg, A.D.1
Kaczmarek, A.2
Krysko, O.3
Vandenabeele, P.4
Krysko, D.V.5
Agostinis, P.6
-
57
-
-
33750221963
-
The unfolded protein response is an important regulator of inflammatory genes in endothelial cells
-
Gargalovic PS, Gharavi NM, Clark MJ, Pagnon J, Yang WP, He A, Truong A, Baruch-Oren T, Berliner JA, Kirchgessner TG, et al. 2006 The unfolded protein response is an important regulator of inflammatory genes in endothelial cells. Arteriosclerosis, Thrombosis, and Vascular Biology 26 2490-2496. (doi:10.1161/01. ATV.0000242903.41158.a1)
-
(2006)
Arteriosclerosis, Thrombosis, and Vascular Biology
, vol.26
, pp. 2490-2496
-
-
Gargalovic, P.S.1
Gharavi, N.M.2
Clark, M.J.3
Pagnon, J.4
Yang, W.P.5
He, A.6
Truong, A.7
Baruch-Oren, T.8
Berliner, J.A.9
Kirchgessner, T.G.10
-
58
-
-
41149118021
-
A decrease in cellular energy status stimulates PERK-dependent eIF2alpha phosphorylation and regulates protein synthesis in pancreatic betacells
-
Gomez E, Powell ML, Bevington A & Herbert TP 2008 A decrease in cellular energy status stimulates PERK-dependent eIF2alpha phosphorylation and regulates protein synthesis in pancreatic betacells. Biochemical Journal 410 485-493. (doi:10.1042/BJ20071367)
-
(2008)
Biochemical Journal
, vol.410
, pp. 485-493
-
-
Gomez, E.1
Powell, M.L.2
Bevington, A.3
Herbert, T.P.4
-
59
-
-
84859799949
-
Stress management at the ER: Regulators of ER stress-induced apoptosis
-
Gorman AM, Healy SJ, Jager R & Samali A 2012 Stress management at the ER: regulators of ER stress-induced apoptosis. Pharmacology & Therapeutics 134 306-316. (doi:10.1016/j.pharmthera.2012.02.003)
-
(2012)
Pharmacology & Therapeutics
, vol.134
, pp. 306-316
-
-
Gorman, A.M.1
Healy, S.J.2
Jager, R.3
Samali, A.4
-
61
-
-
84939639035
-
Profile of the immune and inflammatory response in individuals with prediabetes and type 2 diabetes
-
Grossmann V, Schmitt VH, Zeller T, Panova-Noeva M, Schulz A, Laubert-Reh D, Juenger C, Schnabel RB, Abt TG, Laskowski R, et al. 2015 Profile of the immune and inflammatory response in individuals with prediabetes and type 2 diabetes. Diabetes Care 38 1356-1364. (doi:10.2337/dc14-3008)
-
(2015)
Diabetes Care
, vol.38
, pp. 1356-1364
-
-
Grossmann, V.1
Schmitt, V.H.2
Zeller, T.3
Panova-Noeva, M.4
Schulz, A.5
Laubert-Reh, D.6
Juenger, C.7
Schnabel, R.B.8
Abt, T.G.9
Laskowski, R.10
-
62
-
-
84942193330
-
SIRT1 suppresses cardiomyocyte apoptosis in diabetic cardiomyopathy: An insight into endoplasmic reticulum stress response mechanism
-
Guo R, Liu W, Liu B, Zhang B, Li W & Xu Y 2015 SIRT1 suppresses cardiomyocyte apoptosis in diabetic cardiomyopathy: an insight into endoplasmic reticulum stress response mechanism. International Journal of Cardiology 191 36-45. (doi:10.1016/j.ijcard.2015.04.245)
-
(2015)
International Journal of Cardiology
, vol.191
, pp. 36-45
-
-
Guo, R.1
Liu, W.2
Liu, B.3
Zhang, B.4
Li, W.5
Xu, Y.6
-
63
-
-
79959618962
-
Bcl-2 proteins in diabetes: Mitochondrial pathways of beta-cell death and dysfunction
-
Gurzov EN & Eizirik DL 2011 Bcl-2 proteins in diabetes: mitochondrial pathways of beta-cell death and dysfunction. Trends in Cell Biology 21 424-431. (doi:10.1016/j.tcb.2011.03.001)
-
(2011)
Trends in Cell Biology
, vol.21
, pp. 424-431
-
-
Gurzov, E.N.1
Eizirik, D.L.2
-
64
-
-
70350028224
-
Signaling by IL-1beta+IFN-gamma and ER stress converge on DP5/Hrk activation: A novel mechanism for pancreatic beta-cell apoptosis
-
Gurzov EN, Ortis F, Cunha DA, Gosset G, Li M, Cardozo AK & Eizirik DL 2009 Signaling by IL-1beta+IFN-gamma and ER stress converge on DP5/Hrk activation: a novel mechanism for pancreatic beta-cell apoptosis. Cell Death and Differentiation 16 1539-1550. (doi:10.1038/ cdd.2009.99)
-
(2009)
Cell Death and Differentiation
, vol.16
, pp. 1539-1550
-
-
Gurzov, E.N.1
Ortis, F.2
Cunha, D.A.3
Gosset, G.4
Li, M.5
Cardozo, A.K.6
Eizirik, D.L.7
-
65
-
-
84859436112
-
Pancreatic beta-cells activate a JunB/ATF3-dependent survival pathway during inflammation
-
Gurzov EN, Barthson J, Marhfour I, Ortis F, Naamane N, Igoillo-Esteve M, Gysemans C, Mathieu C, Kitajima S, Marchetti P, et al. 2012 Pancreatic beta-cells activate a JunB/ATF3-dependent survival pathway during inflammation. Oncogene 31 1723-1732. (doi:10.1038/onc.2011.353)
-
(2012)
Oncogene
, vol.31
, pp. 1723-1732
-
-
Gurzov, E.N.1
Barthson, J.2
Marhfour, I.3
Ortis, F.4
Naamane, N.5
Igoillo-Esteve, M.6
Gysemans, C.7
Mathieu, C.8
Kitajima, S.9
Marchetti, P.10
-
66
-
-
43549100675
-
Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis
-
Haataja L, Gurlo T, Huang CJ & Butler PC 2008 Islet amyloid in type 2 diabetes, and the toxic oligomer hypothesis. Endocrine Reviews 29 303-316. (doi:10.1210/er.2007-0037)
-
(2008)
Endocrine Reviews
, vol.29
, pp. 303-316
-
-
Haataja, L.1
Gurlo, T.2
Huang, C.J.3
Butler, P.C.4
-
67
-
-
68049110633
-
IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates
-
Han D, Lerner AG, Vande Walle L, Upton JP, Xu W, Hagen A, Backes BJ, Oakes SA & Papa FR 2009 IRE1alpha kinase activation modes control alternate endoribonuclease outputs to determine divergent cell fates. Cell 138 562-575. (doi:10.1016/j.cell.2009.07.017)
-
(2009)
Cell
, vol.138
, pp. 562-575
-
-
Han, D.1
Lerner, A.G.2
Vande Walle, L.3
Upton, J.P.4
Xu, W.5
Hagen, A.6
Backes, B.J.7
Oakes, S.A.8
Papa, F.R.9
-
68
-
-
84896887059
-
Calcium efflux from the endoplasmic reticulum leads to beta-cell death
-
Hara T, Mahadevan J, Kanekura K, Hara M, Lu S & Urano F 2014 Calcium efflux from the endoplasmic reticulum leads to beta-cell death. Endocrinology 155 758-768. (doi:10.1210/en.2013-1519)
-
(2014)
Endocrinology
, vol.155
, pp. 758-768
-
-
Hara, T.1
Mahadevan, J.2
Kanekura, K.3
Hara, M.4
Lu, S.5
Urano, F.6
-
70
-
-
0037353039
-
An integrated stress response regulates amino acid metabolism and resistance to oxidative stress
-
Harding HP, Zhang Y, Zeng H, Novoa I, Lu PD, Calfon M, Sadri N, Yun C, Popko B, Paules R, et al. 2003 An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. Molecular Cell 11 619-633. (doi:10.1016/S1097-2765(03)00105-9)
-
(2003)
Molecular Cell
, vol.11
, pp. 619-633
-
-
Harding, H.P.1
Zhang, Y.2
Zeng, H.3
Novoa, I.4
Lu, P.D.5
Calfon, M.6
Sadri, N.7
Yun, C.8
Popko, B.9
Paules, R.10
-
71
-
-
84925581887
-
Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress
-
Hasnain SZ, Borg DJ, Harcourt BE, Tong H, Sheng YH, Ng CP, Das I, Wang R, Chen AC, Loudovaris T, et al. 2014 Glycemic control in diabetes is restored by therapeutic manipulation of cytokines that regulate beta cell stress. Nature Medicine 20 1417-1426. (doi:10.1038/ nm.3705)
-
(2014)
Nature Medicine
, vol.20
, pp. 1417-1426
-
-
Hasnain, S.Z.1
Borg, D.J.2
Harcourt, B.E.3
Tong, H.4
Sheng, Y.H.5
Ng, C.P.6
Das, I.7
Wang, R.8
Chen, A.C.9
Loudovaris, T.10
-
72
-
-
84964834830
-
Oxidative and endoplasmic reticulum stress in beta-cell dysfunction in diabetes
-
Hasnain SZ, Prins JB & McGuckin MA 2016 Oxidative and endoplasmic reticulum stress in beta-cell dysfunction in diabetes. Journal of Molecular Endocrinology 56 R33-R54. (doi:10.1530/JME-15-0232)
-
(2016)
Journal of Molecular Endocrinology
, vol.56
, pp. R33-R54
-
-
Hasnain, S.Z.1
Prins, J.B.2
McGuckin, M.A.3
-
73
-
-
84946083953
-
The IRE1alpha/XBP1s pathway is essential for the glucose response and protection of beta cells
-
Hassler JR, Scheuner DL, Wang S, Han J, Kodali VK, Li P, Nguyen J, George JS, Davis C, Wu SP, et al. 2015 The IRE1alpha/XBP1s pathway is essential for the glucose response and protection of beta cells. PLoS Biology 13 e1002277. (doi:10.1371/journal.pbio.1002277)
-
(2015)
PLoS Biology
, vol.13
-
-
Hassler, J.R.1
Scheuner, D.L.2
Wang, S.3
Han, J.4
Kodali, V.K.5
Li, P.6
Nguyen, J.7
George, J.S.8
Davis, C.9
Wu, S.P.10
-
74
-
-
84856111924
-
The unfolded protein response: Controlling cell fate decisions under ER stress and beyond
-
Hetz C 2012 The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nature Reviews in Molecular Cell Biology 13 89-102. (doi:10.1038/nrm3270)
-
(2012)
Nature Reviews in Molecular Cell Biology
, vol.13
, pp. 89-102
-
-
Hetz, C.1
-
75
-
-
77950343252
-
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
-
Hotamisligil GS 2010 Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 140 900-917. (doi:10.1016/j.cell.2010.02.034)
-
(2010)
Cell
, vol.140
, pp. 900-917
-
-
Hotamisligil, G.S.1
-
76
-
-
48349133849
-
Involvement of chronic stresses in rat islet and INS-1 cell glucotoxicity induced by intermittent high glucose
-
Hou ZQ, Li HL, Gao L, Pan L, Zhao JJ & Li GW 2008 Involvement of chronic stresses in rat islet and INS-1 cell glucotoxicity induced by intermittent high glucose. Molecular and Cellular Endocrinology 291 71-78. (doi:10.1016/j.mce.2008.03.004)
-
(2008)
Molecular and Cellular Endocrinology
, vol.291
, pp. 71-78
-
-
Hou, Z.Q.1
Li, H.L.2
Gao, L.3
Pan, L.4
Zhao, J.J.5
Li, G.W.6
-
77
-
-
80051558419
-
Upregulation of pancreatic derived factor (FAM3B) expression in pancreatic beta-cells by MCP-1 (CCL2)
-
Hou X, Wang O, Li Z, Mou H, Chen J, Deng B, Qian L, Liu X & Le Y 2011 Upregulation of pancreatic derived factor (FAM3B) expression in pancreatic beta-cells by MCP-1 (CCL2). Molecular and Cellular Endocrinology 343 18-24. (doi:10.1016/j.mce.2011.05.039)
-
(2011)
Molecular and Cellular Endocrinology
, vol.343
, pp. 18-24
-
-
Hou, X.1
Wang, O.2
Li, Z.3
Mou, H.4
Chen, J.5
Deng, B.6
Qian, L.7
Liu, X.8
Le, Y.9
-
78
-
-
33645815074
-
Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression
-
Hu P, Han Z, Couvillon AD, Kaufman RJ & Exton JH 2006 Autocrine tumor necrosis factor alpha links endoplasmic reticulum stress to the membrane death receptor pathway through IRE1alpha-mediated NF-kappaB activation and down-regulation of TRAF2 expression. Molecular and Cellular Biology 26 3071-3084. (doi:10.1128/ MCB.26.8.3071-3084.2006)
-
(2006)
Molecular and Cellular Biology
, vol.26
, pp. 3071-3084
-
-
Hu, P.1
Han, Z.2
Couvillon, A.D.3
Kaufman, R.J.4
Exton, J.H.5
-
79
-
-
79953034321
-
ER stress and its regulator X-box-binding protein-1 enhance polyIC-induced innate immune response in dendritic cells
-
Hu F, Yu X, Wang H, Zuo D, Guo C, Yi H, Tirosh B, Subjeck JR, Qiu X & Wang XY 2011 ER stress and its regulator X-box-binding protein-1 enhance polyIC-induced innate immune response in dendritic cells. European Journal of Immunology 41 1086-1097. (doi:10.1002/ eji.201040831)
-
(2011)
European Journal of Immunology
, vol.41
, pp. 1086-1097
-
-
Hu, F.1
Yu, X.2
Wang, H.3
Zuo, D.4
Guo, C.5
Yi, H.6
Tirosh, B.7
Subjeck, J.R.8
Qiu, X.9
Wang, X.Y.10
-
80
-
-
34547638958
-
High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes
-
Huang CJ, Lin CY, Haataja L, Gurlo T, Butler AE, Rizza RA & Butler PC 2007 High expression rates of human islet amyloid polypeptide induce endoplasmic reticulum stress mediated beta-cell apoptosis, a characteristic of humans with type 2 but not type 1 diabetes. Diabetes 56 2016-2027. (doi:10.2337/db07-0197)
-
(2007)
Diabetes
, vol.56
, pp. 2016-2027
-
-
Huang, C.J.1
Lin, C.Y.2
Haataja, L.3
Gurlo, T.4
Butler, A.E.5
Rizza, R.A.6
Butler, P.C.7
-
81
-
-
84904156387
-
Valproate pretreatment protects pancreatic beta-cells from palmitate-induced ER stress and apoptosis by inhibiting glycogen synthase kinase-3beta
-
Huang S, Zhu M, Wu W, Rashid A, Liang Y, Hou L, Ning Q & Luo X 2014 Valproate pretreatment protects pancreatic beta-cells from palmitate-induced ER stress and apoptosis by inhibiting glycogen synthase kinase-3beta. Journal of Biomedical Science 21 38. (doi:10.1186/1423-0127-21-38)
-
(2014)
Journal of Biomedical Science
, vol.21
, pp. 38
-
-
Huang, S.1
Zhu, M.2
Wu, W.3
Rashid, A.4
Liang, Y.5
Hou, L.6
Ning, Q.7
Luo, X.8
-
82
-
-
84928346009
-
ATF4 is a novel regulator of MCP-1 in microvascular endothelial cells
-
Huang H, Jing G, Wang JJ, Sheibani N & Zhang SX 2015 ATF4 is a novel regulator of MCP-1 in microvascular endothelial cells. Journal of Inflammation 12 31. (doi:10.1186/s12950-015-0076-1)
-
(2015)
Journal of Inflammation
, vol.12
, pp. 31
-
-
Huang, H.1
Jing, G.2
Wang, J.J.3
Sheibani, N.4
Zhang, S.X.5
-
83
-
-
81855204961
-
Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation
-
Hybertson BM, Gao B, Bose SK & McCord JM 2011 Oxidative stress in health and disease: the therapeutic potential of Nrf2 activation. Molecular Aspects of Medicine 32 234-246. (doi:10.1016/j. mam.2011.10.006)
-
(2011)
Molecular Aspects of Medicine
, vol.32
, pp. 234-246
-
-
Hybertson, B.M.1
Gao, B.2
Bose, S.K.3
McCord, J.M.4
-
84
-
-
77955658618
-
Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes
-
Igoillo-Esteve M, Marselli L, Cunha DA, Ladriere L, Ortis F, Grieco FA, Dotta F, Weir GC, Marchetti P, Eizirik DL, et al. 2010 Palmitate induces a pro-inflammatory response in human pancreatic islets that mimics CCL2 expression by beta cells in type 2 diabetes. Diabetologia 53 1395-1405. (doi:10.1007/s00125-010-1707-y)
-
(2010)
Diabetologia
, vol.53
, pp. 1395-1405
-
-
Igoillo-Esteve, M.1
Marselli, L.2
Cunha, D.A.3
Ladriere, L.4
Ortis, F.5
Grieco, F.A.6
Dotta, F.7
Weir, G.C.8
Marchetti, P.9
Eizirik, D.L.10
-
85
-
-
58249093962
-
Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death
-
Inokuchi Y, Nakajima Y, Shimazawa M, Kurita T, Kubo M, Saito A, Sajiki H, Kudo T, Aihara M, Imaizumi K, et al. 2009 Effect of an inducer of BiP, a molecular chaperone, on endoplasmic reticulum (ER) stress-induced retinal cell death. Investigative Ophthalmology & Visual Science 50 334-344. (doi:10.1167/iovs.08-2123)
-
(2009)
Investigative Ophthalmology & Visual Science
, vol.50
, pp. 334-344
-
-
Inokuchi, Y.1
Nakajima, Y.2
Shimazawa, M.3
Kurita, T.4
Kubo, M.5
Saito, A.6
Sajiki, H.7
Kudo, T.8
Aihara, M.9
Imaizumi, K.10
-
86
-
-
17344362695
-
A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)
-
Inoue H, Tanizawa Y, Wasson J, Behn P, Kalidas K, Bernal-Mizrachi E, Mueckler M, Marshall H, Donis-Keller H, Crock P, et al. 1998 A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome). Nature Genetics 20 143-148. (doi:10.1038/2441)
-
(1998)
Nature Genetics
, vol.20
, pp. 143-148
-
-
Inoue, H.1
Tanizawa, Y.2
Wasson, J.3
Behn, P.4
Kalidas, K.5
Bernal-Mizrachi, E.6
Mueckler, M.7
Marshall, H.8
Donis-Keller, H.9
Crock, P.10
-
87
-
-
84891815469
-
Activating transcription factor 4 links metabolic stress to interleukin-6 expression in macrophages
-
Iwasaki Y, Suganami T, Hachiya R, Shirakawa I, Kim-Saijo M, Tanaka M, Hamaguchi M, Takai-Igarashi T, Nakai M, Miyamoto Y, et al. 2014 Activating transcription factor 4 links metabolic stress to interleukin-6 expression in macrophages. Diabetes 63 152-161. (doi:10.2337/db13-0757)
-
(2014)
Diabetes
, vol.63
, pp. 152-161
-
-
Iwasaki, Y.1
Suganami, T.2
Hachiya, R.3
Shirakawa, I.4
Kim-Saijo, M.5
Tanaka, M.6
Hamaguchi, M.7
Takai-Igarashi, T.8
Nakai, M.9
Miyamoto, Y.10
-
88
-
-
70350310991
-
Glucose regulation of islet stress responses and beta-cell failure in type 2 diabetes
-
Jonas JC, Bensellam M, Duprez J, Elouil H, Guiot Y & Pascal SM 2009 Glucose regulation of islet stress responses and beta-cell failure in type 2 diabetes. Diabetes, Obesity and Metabolism 11 (Supplement 4) 65-81. (doi:10.1111/j.1463-1326.2009.01112.x)
-
(2009)
Diabetes, Obesity and Metabolism
, vol.11
, pp. 65-81
-
-
Jonas, J.C.1
Bensellam, M.2
Duprez, J.3
Elouil, H.4
Guiot, Y.5
Pascal, S.M.6
-
89
-
-
1442321303
-
Activation signal of nuclear factor-kappaB in response to endoplasmic reticulum stress is transduced via IRE1 and tumor necrosis factor receptor-associated factor 2
-
Kaneko M, Niinuma Y & Nomura Y 2003 Activation signal of nuclear factor-kappaB in response to endoplasmic reticulum stress is transduced via IRE1 and tumor necrosis factor receptor-associated factor 2. Biological and Pharmaceutical Bulletin 26 931-935. (doi:10.1248/bpb.26.931)
-
(2003)
Biological and Pharmaceutical Bulletin
, vol.26
, pp. 931-935
-
-
Kaneko, M.1
Niinuma, Y.2
Nomura, Y.3
-
90
-
-
33644845569
-
Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic beta-cell dysfunction and insulin resistance
-
Kaneto H, Nakatani Y, Kawamori D, Miyatsuka T, Matsuoka TA, Matsuhisa M & Yamasaki Y 2006 Role of oxidative stress, endoplasmic reticulum stress, and c-Jun N-terminal kinase in pancreatic beta-cell dysfunction and insulin resistance. International Journal of Biochemistry and Cell Biology 38 782-793. (doi:10.1016/j. biocel.2006.01.004)
-
(2006)
International Journal of Biochemistry and Cell Biology
, vol.38
, pp. 782-793
-
-
Kaneto, H.1
Nakatani, Y.2
Kawamori, D.3
Miyatsuka, T.4
Matsuoka, T.A.5
Matsuhisa, M.6
Yamasaki, Y.7
-
91
-
-
77955411159
-
Tauroursodeoxycholic acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women
-
Kars M, Yang L, Gregor MF, Mohammed BS, Pietka TA, Finck BN, Patterson BW, Horton JD, Mittendorfer B, Hotamisligil GS, et al. 2010 Tauroursodeoxycholic acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women. Diabetes 59 1899-1905. (doi:10.2337/db10-0308)
-
(2010)
Diabetes
, vol.59
, pp. 1899-1905
-
-
Kars, M.1
Yang, L.2
Gregor, M.F.3
Mohammed, B.S.4
Pietka, T.A.5
Finck, B.N.6
Patterson, B.W.7
Horton, J.D.8
Mittendorfer, B.9
Hotamisligil, G.S.10
-
92
-
-
77249150521
-
Endoplasmic reticulum stress and intestinal inflammation
-
Kaser A & Blumberg RS 2010 Endoplasmic reticulum stress and intestinal inflammation. Mucosal Immunology 3 11-16. (doi:10.1038/ mi.2009.122)
-
(2010)
Mucosal Immunology
, vol.3
, pp. 11-16
-
-
Kaser, A.1
Blumberg, R.S.2
-
93
-
-
50249086073
-
XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease
-
Kaser A, Lee AH, Franke A, Glickman JN, Zeissig S, Tilg H, Nieuwenhuis EE, Higgins DE, Schreiber S, Glimcher LH, et al. 2008 XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease. Cell 134 743-756. (doi:10.1016/j.cell.2008.07.021)
-
(2008)
Cell
, vol.134
, pp. 743-756
-
-
Kaser, A.1
Lee, A.H.2
Franke, A.3
Glickman, J.N.4
Zeissig, S.5
Tilg, H.6
Nieuwenhuis, E.E.7
Higgins, D.E.8
Schreiber, S.9
Glimcher, L.H.10
-
94
-
-
9244231766
-
Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: Role of nuclear factor-kappaB and endoplasmic reticulum stress
-
Kharroubi I, Ladriere L, Cardozo AK, Dogusan Z, Cnop M & Eizirik DL 2004 Free fatty acids and cytokines induce pancreatic beta-cell apoptosis by different mechanisms: role of nuclear factor-kappaB and endoplasmic reticulum stress. Endocrinology 145 5087-5096. (doi:10.1210/en.2004-0478)
-
(2004)
Endocrinology
, vol.145
, pp. 5087-5096
-
-
Kharroubi, I.1
Ladriere, L.2
Cardozo, A.K.3
Dogusan, Z.4
Cnop, M.5
Eizirik, D.L.6
-
95
-
-
35848930804
-
Proinflammatory cytokines increase glucose, alanine and triacylglycerol utilization but inhibit insulin secretion in a clonal pancreatic betacell line
-
Kiely A, McClenaghan NH, Flatt PR & Newsholme P 2007 Proinflammatory cytokines increase glucose, alanine and triacylglycerol utilization but inhibit insulin secretion in a clonal pancreatic betacell line. Journal of Endocrinology 195 113-123. (doi:10.1677/ JOE-07-0306)
-
(2007)
Journal of Endocrinology
, vol.195
, pp. 113-123
-
-
Kiely, A.1
McClenaghan, N.H.2
Flatt, P.R.3
Newsholme, P.4
-
96
-
-
84925600182
-
Proteomic analysis of INS-1 rat insulinoma cells: ER stress effects and the protective role of exenatide, a GLP-1 receptor agonist
-
Kim MK, Cho JH, Lee JJ, Son MH & Lee KJ 2015 Proteomic analysis of INS-1 rat insulinoma cells: ER stress effects and the protective role of exenatide, a GLP-1 receptor agonist. PLoS ONE 10 e0120536. (doi:10.1371/journal.pone.0120536)
-
(2015)
PLoS ONE
, vol.10
-
-
Kim, M.K.1
Cho, J.H.2
Lee, J.J.3
Son, M.H.4
Lee, K.J.5
-
97
-
-
23944462868
-
Bidirectional regulation of monocyte chemoattractant protein-1 gene at distinct sites of its promoter by nitric oxide in vascular smooth muscle cells
-
Kodama K, Nishio Y, Sekine O, Sato Y, Egawa K, Maegawa H & Kashiwagi A 2005 Bidirectional regulation of monocyte chemoattractant protein-1 gene at distinct sites of its promoter by nitric oxide in vascular smooth muscle cells. American Journal of Physiology: Cell Physiology 289 C582-C590. (doi:10.1152/ ajpcell.00558.2004)
-
(2005)
American Journal of Physiology: Cell Physiology
, vol.289
, pp. C582-C590
-
-
Kodama, K.1
Nishio, Y.2
Sekine, O.3
Sato, Y.4
Egawa, K.5
Maegawa, H.6
Kashiwagi, A.7
-
98
-
-
38049170584
-
A molecular chaperone inducer protects neurons from ER stress
-
Kudo T, Kanemoto S, Hara H, Morimoto N, Morihara T, Kimura R, Tabira T, Imaizumi K & Takeda M 2008 A molecular chaperone inducer protects neurons from ER stress. Cell Death and Differentiation 15 364-375. (doi:10.1038/sj.cdd.4402276)
-
(2008)
Cell Death and Differentiation
, vol.15
, pp. 364-375
-
-
Kudo, T.1
Kanemoto, S.2
Hara, H.3
Morimoto, N.4
Morihara, T.5
Kimura, R.6
Tabira, T.7
Imaizumi, K.8
Takeda, M.9
-
99
-
-
74849108033
-
Exendin-4 potentiates insulinotropic action partly via increasing beta-cell proliferation and neogenesis and decreasing apoptosis in association with the attenuation of endoplasmic reticulum stress in islets of diabetic rats
-
Kwon DY, Kim YS, Ahn IS, Kim da S, Kang S, Hong SM & Park S 2009 Exendin-4 potentiates insulinotropic action partly via increasing beta-cell proliferation and neogenesis and decreasing apoptosis in association with the attenuation of endoplasmic reticulum stress in islets of diabetic rats. Journal of Pharmacology Science 111 361-371. (doi:10.1254/jphs.09178FP)
-
(2009)
Journal of Pharmacology Science
, vol.111
, pp. 361-371
-
-
Kwon, D.Y.1
Kim, Y.S.2
Ahn, I.S.3
Kim da, S.4
Kang, S.5
Hong, S.M.6
Park, S.7
-
100
-
-
77749246118
-
Enhanced signaling downstream of ribonucleic acid-activated protein kinase-like endoplasmic reticulum kinase potentiates lipotoxic endoplasmic reticulum stress in human islets
-
Ladriere L, Igoillo-Esteve M, Cunha DA, Brion JP, Bugliani M, Marchetti P, Eizirik DL & Cnop M 2010 Enhanced signaling downstream of ribonucleic acid-activated protein kinase-like endoplasmic reticulum kinase potentiates lipotoxic endoplasmic reticulum stress in human islets. Journal of Clinical Endocrinology and Metabolism 95 1442-1449. (doi:10.1210/jc.2009-2322)
-
(2010)
Journal of Clinical Endocrinology and Metabolism
, vol.95
, pp. 1442-1449
-
-
Ladriere, L.1
Igoillo-Esteve, M.2
Cunha, D.A.3
Brion, J.P.4
Bugliani, M.5
Marchetti, P.6
Eizirik, D.L.7
Cnop, M.8
-
101
-
-
84922277623
-
NFAT targets signaling molecules to gene promoters in pancreatic beta-cells
-
Lawrence MC, Borenstein-Auerbach N, McGlynn K, Kunnathodi F, Shahbazov R, Syed I, Kanak M, Takita M, Levy MF & Naziruddin B 2015 NFAT targets signaling molecules to gene promoters in pancreatic beta-cells. Molecular Endocrinology 29 274-288. (doi:10.1210/me.2014-1066)
-
(2015)
Molecular Endocrinology
, vol.29
, pp. 274-288
-
-
Lawrence, M.C.1
Borenstein-Auerbach, N.2
McGlynn, K.3
Kunnathodi, F.4
Shahbazov, R.5
Syed, I.6
Kanak, M.7
Takita, M.8
Levy, M.F.9
Naziruddin, B.10
-
102
-
-
33847677975
-
Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes
-
Laybutt DR, Preston AM, Akerfeldt MC, Kench JG, Busch AK, Biankin AV & Biden TJ 2007 Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes. Diabetologia 50 752-763. (doi:10.1007/s00125-006-0590-z)
-
(2007)
Diabetologia
, vol.50
, pp. 752-763
-
-
Laybutt, D.R.1
Preston, A.M.2
Akerfeldt, M.C.3
Kench, J.G.4
Busch, A.K.5
Biankin, A.V.6
Biden, T.J.7
-
103
-
-
77954385084
-
Tauroursodeoxycholate (TUDCA), chemical chaperone, enhances function of islets by reducing ER stress
-
Lee YY, Hong SH, Lee YJ, Chung SS, Jung HS, Park SG & Park KS 2010 Tauroursodeoxycholate (TUDCA), chemical chaperone, enhances function of islets by reducing ER stress. Biochemical and Biophysical Research Communications 397 735-739. (doi:10.1016/j. bbrc.2010.06.022)
-
(2010)
Biochemical and Biophysical Research Communications
, vol.397
, pp. 735-739
-
-
Lee, Y.Y.1
Hong, S.H.2
Lee, Y.J.3
Chung, S.S.4
Jung, H.S.5
Park, S.G.6
Park, K.S.7
-
104
-
-
84896367457
-
Valproic acid protects motor neuron death by inhibiting oxidative stress and endoplasmic reticulum stress-mediated cytochrome C release after spinal cord injury
-
Lee JY, Maeng S, Kang SR, Choi HY, Oh TH, Ju BG & Yune TY 2014 Valproic acid protects motor neuron death by inhibiting oxidative stress and endoplasmic reticulum stress-mediated cytochrome C release after spinal cord injury. Journal of Neurotrauma 31 582-594. (doi:10.1089/neu.2013.3146)
-
(2014)
Journal of Neurotrauma
, vol.31
, pp. 582-594
-
-
Lee, J.Y.1
Maeng, S.2
Kang, S.R.3
Choi, H.Y.4
Oh, T.H.5
Ju, B.G.6
Yune, T.Y.7
-
105
-
-
84943166086
-
Altered immunometabolism at the interface of increased endoplasmic reticulum (ER) stress in patients with type 2 diabetes
-
Lenin R, Sankaramoorthy A, Mohan V & Balasubramanyam M 2015 Altered immunometabolism at the interface of increased endoplasmic reticulum (ER) stress in patients with type 2 diabetes. Journal of Leukocyte Biology 98 615-622. (doi:10.1189/jlb.3A1214-609R)
-
(2015)
Journal of Leukocyte Biology
, vol.98
, pp. 615-622
-
-
Lenin, R.1
Sankaramoorthy, A.2
Mohan, V.3
Balasubramanyam, M.4
-
106
-
-
84864682160
-
IRE1alpha induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress
-
Lerner AG, Upton JP, Praveen PV, Ghosh R, Nakagawa Y, Igbaria A, Shen S, Nguyen V, Backes BJ, Heiman M, et al. 2012 IRE1alpha induces thioredoxin-interacting protein to activate the NLRP3 inflammasome and promote programmed cell death under irremediable ER stress. Cell Metabolism 16 250-264. (doi:10.1016/j. cmet.2012.07.007)
-
(2012)
Cell Metabolism
, vol.16
, pp. 250-264
-
-
Lerner, A.G.1
Upton, J.P.2
Praveen, P.V.3
Ghosh, R.4
Nakagawa, Y.5
Igbaria, A.6
Shen, S.7
Nguyen, V.8
Backes, B.J.9
Heiman, M.10
-
107
-
-
84985995936
-
Short-term and longterm effects of dipeptidyl peptidase-4 inhibitors in type 2 diabetes mellitus patients with renal impairment: A meta-analysis of randomized controlled trials
-
[in press]
-
Li R, Wang R, Li H, Sun S, Zou M & Cheng G 2015 Short-term and longterm effects of dipeptidyl peptidase-4 inhibitors in type 2 diabetes mellitus patients with renal impairment: a meta-analysis of randomized controlled trials. Diabetes Metabolism Research and Reviews [in press]. (doi:10.1002/dmrr.2731)
-
(2015)
Diabetes Metabolism Research and Reviews
-
-
Li, R.1
Wang, R.2
Li, H.3
Sun, S.4
Zou, M.5
Cheng, G.6
-
108
-
-
33747849846
-
Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1
-
Lipson KL, Fonseca SG, Ishigaki S, Nguyen LX, Foss E, Bortell R, Rossini AA & Urano F 2006 Regulation of insulin biosynthesis in pancreatic beta cells by an endoplasmic reticulum-resident protein kinase IRE1. Cell Metabolism 4 245-254. (doi:10.1016/j. cmet.2006.07.007)
-
(2006)
Cell Metabolism
, vol.4
, pp. 245-254
-
-
Lipson, K.L.1
Fonseca, S.G.2
Ishigaki, S.3
Nguyen, L.X.4
Foss, E.5
Bortell, R.6
Rossini, A.A.7
Urano, F.8
-
109
-
-
45749114525
-
The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells
-
Lipson KL, Ghosh R & Urano F 2008 The role of IRE1alpha in the degradation of insulin mRNA in pancreatic beta-cells. PLoS ONE 3 e1648. (doi:10.1371/journal.pone.0001648)
-
(2008)
PLoS ONE
, vol.3
-
-
Lipson, K.L.1
Ghosh, R.2
Urano, F.3
-
110
-
-
84940009221
-
INSgene mutations: From genetics and beta cell biology to clinical disease
-
Liu M, Sun J, Cui J, Chen W, Guo H, Barbetti F & Arvan P 2015 INSgene mutations: from genetics and beta cell biology to clinical disease. Molecular Aspects of Medicine 42 3-18. (doi:10.1016/j. mam.2014.12.001)
-
(2015)
Molecular Aspects of Medicine
, vol.42
, pp. 3-18
-
-
Liu, M.1
Sun, J.2
Cui, J.3
Chen, W.4
Guo, H.5
Barbetti, F.6
Arvan, P.7
-
111
-
-
5444264022
-
Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response
-
Lu PD, Harding HP & Ron D 2004 Translation reinitiation at alternative open reading frames regulates gene expression in an integrated stress response. Journal of Cell Biology 167 27-33. (doi:10.1083/ jcb.200408003)
-
(2004)
Journal of Cell Biology
, vol.167
, pp. 27-33
-
-
Lu, P.D.1
Harding, H.P.2
Ron, D.3
-
112
-
-
84959871979
-
Review of head-to-head comparisons of glucagon-like peptide-1 receptor agonists
-
Madsbad S 2016 Review of head-to-head comparisons of glucagon-like peptide-1 receptor agonists. Diabetes, Obesity and Metabolism 18 317-332. (doi:10.1111/dom.12596)
-
(2016)
Diabetes, Obesity and Metabolism
, vol.18
, pp. 317-332
-
-
Madsbad, S.1
-
113
-
-
35848957485
-
Endoplasmic reticulum stress and oxidative stress: A vicious cycle or a double-edged sword?
-
Malhotra JD & Kaufman RJ 2007 Endoplasmic reticulum stress and oxidative stress: a vicious cycle or a double-edged sword? Antioxidants & Redox Signaling 9 2277-2293. (doi:10.1089/ ars.2007.1782)
-
(2007)
Antioxidants & Redox Signaling
, vol.9
, pp. 2277-2293
-
-
Malhotra, J.D.1
Kaufman, R.J.2
-
115
-
-
35848963392
-
The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients
-
Marchetti P, Bugliani M, Lupi R, Marselli L, Masini M, Boggi U, Filipponi F, Weir GC, Eizirik DL & Cnop M 2007 The endoplasmic reticulum in pancreatic beta cells of type 2 diabetes patients. Diabetologia 50 2486-2494. (doi:10.1007/s00125-007-0816-8)
-
(2007)
Diabetologia
, vol.50
, pp. 2486-2494
-
-
Marchetti, P.1
Bugliani, M.2
Lupi, R.3
Marselli, L.4
Masini, M.5
Boggi, U.6
Filipponi, F.7
Weir, G.C.8
Eizirik, D.L.9
Cnop, M.10
-
116
-
-
84866130866
-
Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes
-
Marhfour I, Lopez XM, Lefkaditis D, Salmon I, Allagnat F, Richardson SJ, Morgan NG & Eizirik DL 2012 Expression of endoplasmic reticulum stress markers in the islets of patients with type 1 diabetes. Diabetologia 55 2417-2420. (doi:10.1007/s00125-012-2604-3)
-
(2012)
Diabetologia
, vol.55
, pp. 2417-2420
-
-
Marhfour, I.1
Lopez, X.M.2
Lefkaditis, D.3
Salmon, I.4
Allagnat, F.5
Richardson, S.J.6
Morgan, N.G.7
Eizirik, D.L.8
-
117
-
-
84862577245
-
Deletion of C/EBP homologous protein (Chop) in C57Bl/6 mice dissociates obesity from insulin resistance
-
Maris M, Overbergh L, Gysemans C, Waget A, Cardozo AK, Verdrengh E, Cunha JP, Gotoh T, Cnop M, Eizirik DL, et al. 2012 Deletion of C/EBP homologous protein (Chop) in C57Bl/6 mice dissociates obesity from insulin resistance. Diabetologia 55 1167-1178. (doi:10.1007/s00125-011-2427-7)
-
(2012)
Diabetologia
, vol.55
, pp. 1167-1178
-
-
Maris, M.1
Overbergh, L.2
Gysemans, C.3
Waget, A.4
Cardozo, A.K.5
Verdrengh, E.6
Cunha, J.P.7
Gotoh, T.8
Cnop, M.9
Eizirik, D.L.10
-
119
-
-
77951290227
-
TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages
-
Martinon F, Chen X, Lee AH & Glimcher LH 2010 TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages. Nature Immunology 11 411-418. (doi:10.1038/ni.1857)
-
(2010)
Nature Immunology
, vol.11
, pp. 411-418
-
-
Martinon, F.1
Chen, X.2
Lee, A.H.3
Glimcher, L.H.4
-
121
-
-
0035144493
-
Gadd153 sensitizes cells to endoplasmic reticulum stress by downregulating Bcl2 and perturbing the cellular redox state
-
McCullough KD, Martindale JL, Klotz LO, Aw TY & Holbrook NJ 2001 Gadd153 sensitizes cells to endoplasmic reticulum stress by downregulating Bcl2 and perturbing the cellular redox state. Molecular Cell Biology 21 1249-1259. (doi:10.1128/MCB.21.4.1249-1259.2001)
-
(2001)
Molecular Cell Biology
, vol.21
, pp. 1249-1259
-
-
McCullough, K.D.1
Martindale, J.L.2
Klotz, L.O.3
Aw, T.Y.4
Holbrook, N.J.5
-
122
-
-
84906661993
-
Recognition of posttranslationally modified GAD65 epitopes in subjects with type 1 diabetes
-
McGinty JW, Chow IT, Greenbaum C, Odegard J, Kwok WW & James EA 2014 Recognition of posttranslationally modified GAD65 epitopes in subjects with type 1 diabetes. Diabetes 63 3033-3040. (doi:10.2337/ db13-1952)
-
(2014)
Diabetes
, vol.63
, pp. 3033-3040
-
-
McGinty, J.W.1
Chow, I.T.2
Greenbaum, C.3
Odegard, J.4
Kwok, W.W.5
James, E.A.6
-
123
-
-
77950352322
-
Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax
-
McKenzie MD, Jamieson E, Jansen ES, Scott CL, Huang DC, Bouillet P, Allison J, Kay TW, Strasser A & Thomas HE 2010 Glucose induces pancreatic islet cell apoptosis that requires the BH3-only proteins Bim and Puma and multi-BH domain protein Bax. Diabetes 59 644-652. (doi:10.2337/db09-1151)
-
(2010)
Diabetes
, vol.59
, pp. 644-652
-
-
McKenzie, M.D.1
Jamieson, E.2
Jansen, E.S.3
Scott, C.L.4
Huang, D.C.5
Bouillet, P.6
Allison, J.7
Kay, T.W.8
Strasser, A.9
Thomas, H.E.10
-
124
-
-
84862742723
-
Mild endoplasmic reticulum stress augments the proinflammatory effect of IL-1beta in pancreatic rat beta-cells via the IRE1alpha/XBP1s pathway
-
Miani M, Colli ML, Ladriere L, Cnop M & Eizirik DL 2012 Mild endoplasmic reticulum stress augments the proinflammatory effect of IL-1beta in pancreatic rat beta-cells via the IRE1alpha/XBP1s pathway. Endocrinology 153 3017-3028. (doi:10.1210/en.2011-2090)
-
(2012)
Endocrinology
, vol.153
, pp. 3017-3028
-
-
Miani, M.1
Colli, M.L.2
Ladriere, L.3
Cnop, M.4
Eizirik, D.L.5
-
125
-
-
79955597257
-
C/EBP homologous protein deficiency attenuates myocardial reperfusion injury by inhibiting myocardial apoptosis and inflammation
-
Miyazaki Y, Kaikita K, Endo M, Horio E, Miura M, Tsujita K, Hokimoto S, Yamamuro M, Iwawaki T, Gotoh T, et al. 2011 C/EBP homologous protein deficiency attenuates myocardial reperfusion injury by inhibiting myocardial apoptosis and inflammation. Arteriosclerosis, Thrombosis, and Vascular Biology 31 1124-1132. (doi:10.1161/ ATVBAHA.111.224519)
-
(2011)
Arteriosclerosis, Thrombosis, and Vascular Biology
, vol.31
, pp. 1124-1132
-
-
Miyazaki, Y.1
Kaikita, K.2
Endo, M.3
Horio, E.4
Miura, M.5
Tsujita, K.6
Hokimoto, S.7
Yamamuro, M.8
Iwawaki, T.9
Gotoh, T.10
-
126
-
-
84925725109
-
Endoplasmic reticulum stress and Nrf2 repression in circulating cells of type 2 diabetic patients without the recommended glycemic goals
-
Mozzini C, Garbin U, Stranieri C, Pasini A, Solani E, Tinelli IA, Cominacini L & Fratta Pasini AM 2015 Endoplasmic reticulum stress and Nrf2 repression in circulating cells of type 2 diabetic patients without the recommended glycemic goals. Free Radical Research 49 244-252. (doi:10.3109/10715762.2014.997229)
-
(2015)
Free Radical Research
, vol.49
, pp. 244-252
-
-
Mozzini, C.1
Garbin, U.2
Stranieri, C.3
Pasini, A.4
Solani, E.5
Tinelli, I.A.6
Cominacini, L.7
Fratta Pasini, A.M.8
-
127
-
-
65649084877
-
Positive role of CCAAT/enhancerbinding protein homologous protein, a transcription factor involved in the endoplasmic reticulum stress response in the development of colitis
-
Namba T, Tanaka K, Ito Y, Ishihara T, Hoshino T, Gotoh T, Endo M, Sato K & Mizushima T 2009 Positive role of CCAAT/enhancerbinding protein homologous protein, a transcription factor involved in the endoplasmic reticulum stress response in the development of colitis. American Journal of Pathology 174 1786-1798. (doi:10.2353/ ajpath.2009.080864)
-
(2009)
American Journal of Pathology
, vol.174
, pp. 1786-1798
-
-
Namba, T.1
Tanaka, K.2
Ito, Y.3
Ishihara, T.4
Hoshino, T.5
Gotoh, T.6
Endo, M.7
Sato, K.8
Mizushima, T.9
-
128
-
-
84957878858
-
Incretin therapies: Highlighting common features and differences in the modes of action of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors
-
Nauck M 2016 Incretin therapies: highlighting common features and differences in the modes of action of glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors. Diabetes, Obesity and Metabolism 18 203-216. (doi:10.1111/dom.12591)
-
(2016)
Diabetes, Obesity and Metabolism
, vol.18
, pp. 203-216
-
-
Nauck, M.1
-
129
-
-
12444335255
-
The JNK binding domain of islet-brain 1 inhibits IL-1 induced JNK activity and apoptosis but not the transcription of key proapoptotic or protective genes in insulin-secreting cell lines
-
Nikulina MA, Sandhu N, Shamim Z, Andersen NA, Oberson A, Dupraz P, Thorens B, Karlsen AE, Bonny C & Mandrup-Poulsen T 2003 The JNK binding domain of islet-brain 1 inhibits IL-1 induced JNK activity and apoptosis but not the transcription of key proapoptotic or protective genes in insulin-secreting cell lines. Cytokine 24 13-24. (doi:10.1016/S1043-4666(03)00242-4)
-
(2003)
Cytokine
, vol.24
, pp. 13-24
-
-
Nikulina, M.A.1
Sandhu, N.2
Shamim, Z.3
Andersen, N.A.4
Oberson, A.5
Dupraz, P.6
Thorens, B.7
Karlsen, A.E.8
Bonny, C.9
Mandrup-Poulsen, T.10
-
130
-
-
22844439230
-
Cell permeable peptide of JNK inhibitor prevents islet apoptosis immediately after isolation and improves islet graft function
-
Noguchi H, Nakai Y, Matsumoto S, Kawaguchi M, Ueda M, Okitsu T, Iwanaga Y, Yonekawa Y, Nagata H, Minami K, et al. 2005 Cell permeable peptide of JNK inhibitor prevents islet apoptosis immediately after isolation and improves islet graft function. American Journal of Transplantation 5 1848-1855. (doi:10.1111/j.1600-6143.2005.00985.x)
-
(2005)
American Journal of Transplantation
, vol.5
, pp. 1848-1855
-
-
Noguchi, H.1
Nakai, Y.2
Matsumoto, S.3
Kawaguchi, M.4
Ueda, M.5
Okitsu, T.6
Iwanaga, Y.7
Yonekawa, Y.8
Nagata, H.9
Minami, K.10
-
131
-
-
40949110598
-
Effect of JNK inhibitor during islet isolation and transplantation
-
Noguchi H, Matsumoto S, Kobayashi N, Hayashi S, Iwanaga Y, Nagata H, Jackson A, Naziruddin B, Okitsu T & Levy MF 2008 Effect of JNK inhibitor during islet isolation and transplantation. Transplantation Proceedings 40 379-381. (doi:10.1016/j.transproceed.2008.01.055)
-
(2008)
Transplantation Proceedings
, vol.40
, pp. 379-381
-
-
Noguchi, H.1
Matsumoto, S.2
Kobayashi, N.3
Hayashi, S.4
Iwanaga, Y.5
Nagata, H.6
Jackson, A.7
Naziruddin, B.8
Okitsu, T.9
Levy, M.F.10
-
132
-
-
84875069480
-
Exendin-4 inhibits glucolipotoxic ER stress in pancreatic beta cells via regulation of SREBP1c and C/EBPbeta transcription factors
-
Oh YS, Lee YJ, Kang Y, Han J, Lim OK & Jun HS 2013 Exendin-4 inhibits glucolipotoxic ER stress in pancreatic beta cells via regulation of SREBP1c and C/EBPbeta transcription factors. Journal of Endocrinology 216 343-352. (doi:10.1530/JOE-12-0311)
-
(2013)
Journal of Endocrinology
, vol.216
, pp. 343-352
-
-
Oh, Y.S.1
Lee, Y.J.2
Kang, Y.3
Han, J.4
Lim, O.K.5
Jun, H.S.6
-
133
-
-
77449145225
-
Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary betacells
-
Ortis F, Naamane N, Flamez D, Ladriere L, Moore F, Cunha DA, Colli ML, Thykjaer T, Thorsen K, Orntoft TF, et al. 2010 Cytokines interleukin-1beta and tumor necrosis factor-alpha regulate different transcriptional and alternative splicing networks in primary betacells. Diabetes 59 358-374. (doi:10.2337/db09-1159)
-
(2010)
Diabetes
, vol.59
, pp. 358-374
-
-
Ortis, F.1
Naamane, N.2
Flamez, D.3
Ladriere, L.4
Moore, F.5
Cunha, D.A.6
Colli, M.L.7
Thykjaer, T.8
Thorsen, K.9
Orntoft, T.F.10
-
134
-
-
84859269961
-
Differential usage of NF-kappaB activating signals by IL-1beta and TNF-alpha in pancreatic beta cells
-
Ortis F, Miani M, Colli ML, Cunha DA, Gurzov EN, Allagnat F, Chariot A & Eizirik DL 2012 Differential usage of NF-kappaB activating signals by IL-1beta and TNF-alpha in pancreatic beta cells. FEBS Letters 586 984-989. (doi:10.1016/j.febslet.2012.02.021)
-
(2012)
FEBS Letters
, vol.586
, pp. 984-989
-
-
Ortis, F.1
Miani, M.2
Colli, M.L.3
Cunha, D.A.4
Gurzov, E.N.5
Allagnat, F.6
Chariot, A.7
Eizirik, D.L.8
-
135
-
-
79954421880
-
The binary switch that controls the life and death decisions of ER stressed beta cells
-
Oslowski CM & Urano F 2011a The binary switch that controls the life and death decisions of ER stressed beta cells. Current Opinion in Cell Biology 23 207-215. (doi:10.1016/j.ceb.2010.11.005)
-
(2011)
Current Opinion in Cell Biology
, vol.23
, pp. 207-215
-
-
Oslowski, C.M.1
Urano, F.2
-
136
-
-
79251525523
-
Measuring ER stress and the unfolded protein response using mammalian tissue culture system
-
Oslowski CM & Urano F 2011b Measuring ER stress and the unfolded protein response using mammalian tissue culture system. Methods in Enzymology 490 71-92. (doi:10.1016/B978-0-12-385114-7.00004-0)
-
(2011)
Methods in Enzymology
, vol.490
, pp. 71-92
-
-
Oslowski, C.M.1
Urano, F.2
-
137
-
-
84864693470
-
Thioredoxininteracting protein mediates ER stress-induced beta cell death through initiation of the inflammasome
-
Oslowski CM, Hara T, O'Sullivan-Murphy B, Kanekura K, Lu S, Hara M, Ishigaki S, Zhu LJ, Hayashi E, Hui ST, et al. 2012 Thioredoxininteracting protein mediates ER stress-induced beta cell death through initiation of the inflammasome. Cell Metabolism 16 265-273. (doi:10.1016/j.cmet.2012.07.005)
-
(2012)
Cell Metabolism
, vol.16
, pp. 265-273
-
-
Oslowski, C.M.1
Hara, T.2
O'Sullivan-Murphy, B.3
Kanekura, K.4
Lu, S.5
Hara, M.6
Ishigaki, S.7
Zhu, L.J.8
Hayashi, E.9
Hui, S.T.10
-
138
-
-
1842843855
-
Roles of CHOP/GADD153 in endoplasmic reticulum stress
-
Oyadomari S & Mori M 2004 Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death and Differentiation 11 381-389. (doi:10.1038/sj.cdd.4401373)
-
(2004)
Cell Death and Differentiation
, vol.11
, pp. 381-389
-
-
Oyadomari, S.1
Mori, M.2
-
139
-
-
0036022403
-
Endoplasmic reticulum stressmediated apoptosis in pancreatic beta-cells
-
Oyadomari S, Araki E & Mori M 2002a Endoplasmic reticulum stressmediated apoptosis in pancreatic beta-cells. Apoptosis 7 335-345. (doi:10.1023/A:1016175429877)
-
(2002)
Apoptosis
, vol.7
, pp. 335-345
-
-
Oyadomari, S.1
Araki, E.2
Mori, M.3
-
140
-
-
0036175128
-
Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes
-
Oyadomari S, Koizumi A, Takeda K, Gotoh T, Akira S, Araki E & Mori M 2002b Targeted disruption of the Chop gene delays endoplasmic reticulum stress-mediated diabetes. Journal of Clinical Investigation 109 525-532. (doi:10.1172/JCI14550)
-
(2002)
Journal of Clinical Investigation
, vol.109
, pp. 525-532
-
-
Oyadomari, S.1
Koizumi, A.2
Takeda, K.3
Gotoh, T.4
Akira, S.5
Araki, E.6
Mori, M.7
-
141
-
-
33748069813
-
Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes
-
Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Gorgun CZ & Hotamisligil GS 2006 Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes. Science 313 1137-1140. (doi:10.1126/ science.1128294)
-
(2006)
Science
, vol.313
, pp. 1137-1140
-
-
Ozcan, U.1
Yilmaz, E.2
Ozcan, L.3
Furuhashi, M.4
Vaillancourt, E.5
Smith, R.O.6
Gorgun, C.Z.7
Hotamisligil, G.S.8
-
142
-
-
84864657351
-
Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
-
Pal D, Dasgupta S, Kundu R, Maitra S, Das G, Mukhopadhyay S, Ray S, Majumdar SS & Bhattacharya S 2012 Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance. Nature Medicine 18 1279-1285. (doi:10.1038/nm.2851)
-
(2012)
Nature Medicine
, vol.18
, pp. 1279-1285
-
-
Pal, D.1
Dasgupta, S.2
Kundu, R.3
Maitra, S.4
Das, G.5
Mukhopadhyay, S.6
Ray, S.7
Majumdar, S.S.8
Bhattacharya, S.9
-
143
-
-
31144432093
-
BiP regulates autoimmune inflammation and tissue damage
-
Panayi GS & Corrigall VM 2006 BiP regulates autoimmune inflammation and tissue damage. Autoimmunity Reviews 5 140-142. (doi:10.1016/j. autrev.2005.08.006)
-
(2006)
Autoimmunity Reviews
, vol.5
, pp. 140-142
-
-
Panayi, G.S.1
Corrigall, V.M.2
-
144
-
-
79952003242
-
Valproate reduces CHOP levels and preserves oligodendrocytes and axons after spinal cord injury
-
Penas C, Verdu E, Asensio-Pinilla E, Guzman-Lenis MS, Herrando-Grabulosa M, Navarro X & Casas C 2011 Valproate reduces CHOP levels and preserves oligodendrocytes and axons after spinal cord injury. Neuroscience 178 33-44. (doi:10.1016/j. neuroscience.2011.01.012)
-
(2011)
Neuroscience
, vol.178
, pp. 33-44
-
-
Penas, C.1
Verdu, E.2
Asensio-Pinilla, E.3
Guzman-Lenis, M.S.4
Herrando-Grabulosa, M.5
Navarro, X.6
Casas, C.7
-
145
-
-
84977919613
-
Low-grade inflammation, obesity, and diabetes
-
Pereira SS & Alvarez-Leite JI 2014 Low-grade inflammation, obesity, and diabetes. Current Obesisty Reports 3 422-431. (doi:10.1007/s13679-014-0124-9)
-
(2014)
Current Obesisty Reports
, vol.3
, pp. 422-431
-
-
Pereira, S.S.1
Alvarez-Leite, J.I.2
-
146
-
-
79960551691
-
Endoplasmic reticulum calcium depletion impacts chaperone secretion, innate immunity, and phagocytic uptake of cells
-
Peters LR & Raghavan M 2011 Endoplasmic reticulum calcium depletion impacts chaperone secretion, innate immunity, and phagocytic uptake of cells. Journal of Immunology 187 919-931. (doi:10.4049/ jimmunol.1100690)
-
(2011)
Journal of Immunology
, vol.187
, pp. 919-931
-
-
Peters, L.R.1
Raghavan, M.2
-
147
-
-
77955023666
-
BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response
-
Pincus D, Chevalier MW, Aragon T, van Anken E, Vidal SE, El-Samad H & Walter P 2010 BiP binding to the ER-stress sensor Ire1 tunes the homeostatic behavior of the unfolded protein response. PLoS Biology 8 e1000415. (doi:10.1371/journal.pbio.1000415)
-
(2010)
PLoS Biology
, vol.8
-
-
Pincus, D.1
Chevalier, M.W.2
Aragon, T.3
van Anken, E.4
Vidal, S.E.5
El-Samad, H.6
Walter, P.7
-
148
-
-
33646533330
-
Interferon-gamma potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms
-
Pirot P, Eizirik DL & Cardozo AK 2006 Interferon-gamma potentiates endoplasmic reticulum stress-induced death by reducing pancreatic beta cell defence mechanisms. Diabetologia 49 1229-1236. (doi:10.1007/s00125-006-0214-7)
-
(2006)
Diabetologia
, vol.49
, pp. 1229-1236
-
-
Pirot, P.1
Eizirik, D.L.2
Cardozo, A.K.3
-
149
-
-
34147106529
-
Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs
-
Pirot P, Naamane N, Libert F, Magnusson NE, Orntoft TF, Cardozo AK & Eizirik DL 2007a Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs. Diabetologia 50 1006-1014. (doi:10.1007/s00125-007-0609-0)
-
(2007)
Diabetologia
, vol.50
, pp. 1006-1014
-
-
Pirot, P.1
Naamane, N.2
Libert, F.3
Magnusson, N.E.4
Orntoft, T.F.5
Cardozo, A.K.6
Eizirik, D.L.7
-
150
-
-
34047235220
-
Transcriptional regulation of the endoplasmic reticulum (ER) stress gene Chop in pancreatic insulin producing cells
-
Pirot P, Ortis F, Cnop M, Ma Y, Hendershot LM, Eizirik DL & Cardozo AK 2007b Transcriptional regulation of the endoplasmic reticulum (ER) stress gene Chop in pancreatic insulin producing cells. Diabetes 56 1069-1077. (doi:10.2337/db06-1253)
-
(2007)
Diabetes
, vol.56
, pp. 1069-1077
-
-
Pirot, P.1
Ortis, F.2
Cnop, M.3
Ma, Y.4
Hendershot, L.M.5
Eizirik, D.L.6
Cardozo, A.K.7
-
151
-
-
84911874159
-
Extracellular cell stress proteins as biomarkers of human disease
-
Pockley AG, Henderson B & Multhoff G 2014 Extracellular cell stress proteins as biomarkers of human disease. Biochemical Society Transactions 42 1744-1751. (doi:10.1042/BST20140205)
-
(2014)
Biochemical Society Transactions
, vol.42
, pp. 1744-1751
-
-
Pockley, A.G.1
Henderson, B.2
Multhoff, G.3
-
152
-
-
42449102605
-
Heterozygous missense mutations in the insulin gene are linked to permanent diabetes appearing in the neonatal period or in early infancy: A report from the French ND (Neonatal Diabetes) Study Group
-
Polak M, Dechaume A, Cave H, Nimri R, Crosnier H, Sulmont V, de Kerdanet M, Scharfmann R, Lebenthal Y, Froguel P, et al. 2008 Heterozygous missense mutations in the insulin gene are linked to permanent diabetes appearing in the neonatal period or in early infancy: a report from the French ND (Neonatal Diabetes) Study Group. Diabetes 57 1115-1119. (doi:10.2337/db07-1358)
-
(2008)
Diabetes
, vol.57
, pp. 1115-1119
-
-
Polak, M.1
Dechaume, A.2
Cave, H.3
Nimri, R.4
Crosnier, H.5
Sulmont, V.6
de Kerdanet, M.7
Scharfmann, R.8
Lebenthal, Y.9
Froguel, P.10
-
154
-
-
84903169952
-
ATF6 mediates a pro-inflammatory synergy between ER stress and TLR activation in the pathogenesis of liver ischemia-reperfusion injury
-
Rao J, Yue S, Fu Y, Zhu J, Wang X, Busuttil RW, Kupiec-Weglinski JW, Lu L & Zhai Y 2014 ATF6 mediates a pro-inflammatory synergy between ER stress and TLR activation in the pathogenesis of liver ischemia-reperfusion injury. American Journal of Transplantation 14 1552-1561. (doi:10.1111/ajt.12711)
-
(2014)
American Journal of Transplantation
, vol.14
, pp. 1552-1561
-
-
Rao, J.1
Yue, S.2
Fu, Y.3
Zhu, J.4
Wang, X.5
Busuttil, R.W.6
Kupiec-Weglinski, J.W.7
Lu, L.8
Zhai, Y.9
-
155
-
-
0346846765
-
Global profiling of double stranded RNA-and IFNgamma-induced genes in rat pancreatic beta cells
-
Rasschaert J, Liu D, Kutlu B, Cardozo AK, Kruhoffer M, Orntoft TF & Eizirik DL 2003 Global profiling of double stranded RNA-and IFNgamma-induced genes in rat pancreatic beta cells. Diabetologia 46 1641-1657. (doi:10.1007/s00125-003-1245-y)
-
(2003)
Diabetologia
, vol.46
, pp. 1641-1657
-
-
Rasschaert, J.1
Liu, D.2
Kutlu, B.3
Cardozo, A.K.4
Kruhoffer, M.5
Orntoft, T.F.6
Eizirik, D.L.7
-
156
-
-
84921919130
-
Citrullinated glucose-regulated protein 78 is an autoantigen in type 1 diabetes
-
Rondas D, Crevecoeur I, D'Hertog W, Ferreira GB, Staes A, Garg AD, Eizirik DL, Agostinis P, Gevaert K, Overbergh L, et al. 2015 Citrullinated glucose-regulated protein 78 is an autoantigen in type 1 diabetes. Diabetes 64 573-586. (doi:10.2337/ db14-0621)
-
(2015)
Diabetes
, vol.64
, pp. 573-586
-
-
Rondas, D.1
Crevecoeur, I.2
D'Hertog, W.3
Ferreira, G.B.4
Staes, A.5
Garg, A.D.6
Eizirik, D.L.7
Agostinis, P.8
Gevaert, K.9
Overbergh, L.10
-
158
-
-
82255185820
-
PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic beta-cell apoptosis via regulation of the BH3-only protein Bim
-
Santin I, Moore F, Colli ML, Gurzov EN, Marselli L, Marchetti P & Eizirik DL 2011 PTPN2, a candidate gene for type 1 diabetes, modulates pancreatic beta-cell apoptosis via regulation of the BH3-only protein Bim. Diabetes 60 3279-3288. (doi:10.2337/db11-0758)
-
(2011)
Diabetes
, vol.60
, pp. 3279-3288
-
-
Santin, I.1
Moore, F.2
Colli, M.L.3
Gurzov, E.N.4
Marselli, L.5
Marchetti, P.6
Eizirik, D.L.7
-
159
-
-
79955782921
-
CHOP deletion does not impact the development of diabetes but suppresses the early production of insulin autoantibody in the NOD mouse
-
Satoh T, Abiru N, Kobayashi M, Zhou H, Nakamura K, Kuriya G, Nakamura H, Nagayama Y, Kawasaki E, Yamasaki H, et al. 2011 CHOP deletion does not impact the development of diabetes but suppresses the early production of insulin autoantibody in the NOD mouse. Apoptosis 16 438-448. (doi:10.1007/s10495-011-0576-2)
-
(2011)
Apoptosis
, vol.16
, pp. 438-448
-
-
Satoh, T.1
Abiru, N.2
Kobayashi, M.3
Zhou, H.4
Nakamura, K.5
Kuriya, G.6
Nakamura, H.7
Nagayama, Y.8
Kawasaki, E.9
Yamasaki, H.10
-
160
-
-
22544444513
-
Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis
-
Scheuner D, Mierde DV, Song B, Flamez D, Creemers JW, Tsukamoto K, Ribick M, Schuit FC & Kaufman RJ 2005 Control of mRNA translation preserves endoplasmic reticulum function in beta cells and maintains glucose homeostasis. Nature Medicine 11 757-764. (doi:10.1038/nm1259)
-
(2005)
Nature Medicine
, vol.11
, pp. 757-764
-
-
Scheuner, D.1
Mierde, D.V.2
Song, B.3
Flamez, D.4
Creemers, J.W.5
Tsukamoto, K.6
Ribick, M.7
Schuit, F.C.8
Kaufman, R.J.9
-
161
-
-
79251476847
-
Report of the committee on the classification and diagnostic criteria of diabetes mellitus
-
Seino Y, Nanjo K, Tajima N, Kadowaki T, Kashiwagi A, Araki E, Ito C, Inagaki N, Iwamoto Y & Committee of the Japan Diabetes Society on the Diagnostic Criteria of Diabetes Mellitus 2010 Report of the committee on the classification and diagnostic criteria of diabetes mellitus. Journal of Diabetes Investigation 1 212-228. (doi:10.1111/j.2040-1124.2010.00074.x)
-
(2010)
Journal of Diabetes Investigation
, vol.1
, pp. 212-228
-
-
Seino, Y.1
Nanjo, K.2
Tajima, N.3
Kadowaki, T.4
Kashiwagi, A.5
Araki, E.6
Ito, C.7
Inagaki, N.8
Iwamoto, Y.9
-
162
-
-
47949127583
-
Endoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases insulin gene expression via up-regulation of orphan nuclear receptor small heterodimer partner
-
Seo HY, Kim YD, Lee KM, Min AK, Kim MK, Kim HS, Won KC, Park JY, Lee KU, Choi HS, et al. 2008 Endoplasmic reticulum stress-induced activation of activating transcription factor 6 decreases insulin gene expression via up-regulation of orphan nuclear receptor small heterodimer partner. Endocrinology 149 3832-3841. (doi:10.1210/ en.2008-0015)
-
(2008)
Endocrinology
, vol.149
, pp. 3832-3841
-
-
Seo, H.Y.1
Kim, Y.D.2
Lee, K.M.3
Min, A.K.4
Kim, M.K.5
Kim, H.S.6
Won, K.C.7
Park, J.Y.8
Lee, K.U.9
Choi, H.S.10
-
163
-
-
0035971493
-
AP-1 in cell proliferation and survival
-
Shaulian E & Karin M 2001 AP-1 in cell proliferation and survival. Oncogene 20 2390-2400. (doi:10.1038/sj.onc.1204383)
-
(2001)
Oncogene
, vol.20
, pp. 2390-2400
-
-
Shaulian, E.1
Karin, M.2
-
164
-
-
78650907445
-
A single NFkappaB system for both canonical and non-canonical signaling
-
Shih VF, Tsui R, Caldwell A & Hoffmann A 2011 A single NFkappaB system for both canonical and non-canonical signaling. Cell Research 21 86-102. (doi:10.1038/cr.2010.161)
-
(2011)
Cell Research
, vol.21
, pp. 86-102
-
-
Shih, V.F.1
Tsui, R.2
Caldwell, A.3
Hoffmann, A.4
-
165
-
-
81455161068
-
Detection of autoantibodies to citrullinated BiP in rheumatoid arthritis patients and proinflammatory role of citrullinated BiP in collagen-induced arthritis
-
Shoda H, Fujio K, Shibuya M, Okamura T, Sumitomo S, Okamoto A, Sawada T & Yamamoto K 2011 Detection of autoantibodies to citrullinated BiP in rheumatoid arthritis patients and proinflammatory role of citrullinated BiP in collagen-induced arthritis. Arthritis Research and Therapy 13 R191.
-
(2011)
Arthritis Research and Therapy
, vol.13
-
-
Shoda, H.1
Fujio, K.2
Shibuya, M.3
Okamura, T.4
Sumitomo, S.5
Okamoto, A.6
Sawada, T.7
Yamamoto, K.8
-
166
-
-
84902436230
-
Metformin attenuates palmitate-induced endoplasmic reticulum stress, serine phosphorylation of IRS-1 and apoptosis in rat insulinoma cells
-
Simon-Szabo L, Kokas M, Mandl J, Keri G & Csala M 2014 Metformin attenuates palmitate-induced endoplasmic reticulum stress, serine phosphorylation of IRS-1 and apoptosis in rat insulinoma cells. PLoS ONE 9 e97868. (doi:10.1371/journal.pone.0097868)
-
(2014)
PLoS ONE
, vol.9
-
-
Simon-Szabo, L.1
Kokas, M.2
Mandl, J.3
Keri, G.4
Csala, M.5
-
167
-
-
84940702679
-
Anti oxidant potential of metformin and pioglitazone in type 2 diabetes mellitus: Beyond their anti glycemic effect
-
Singh RK, Gupta B, Tripathi K & Singh SK 2015 Anti oxidant potential of metformin and pioglitazone in type 2 diabetes mellitus: beyond their anti glycemic effect. Diabetes and Metabolic Syndrome 10 102-104. (doi:10.1016/j.dsx.2015.08.016)
-
(2015)
Diabetes and Metabolic Syndrome
, vol.10
, pp. 102-104
-
-
Singh, R.K.1
Gupta, B.2
Tripathi, K.3
Singh, S.K.4
-
168
-
-
47049098902
-
Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-beta induction via X-box binding protein 1
-
Smith JA, Turner MJ, DeLay ML, Klenk EI, Sowders DP & Colbert RA 2008 Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-beta induction via X-box binding protein 1. European Journal of Immunology 38 1194-1203. (doi:10.1002/eji.200737882)
-
(2008)
European Journal of Immunology
, vol.38
, pp. 1194-1203
-
-
Smith, J.A.1
Turner, M.J.2
DeLay, M.L.3
Klenk, E.I.4
Sowders, D.P.5
Colbert, R.A.6
-
169
-
-
55849096988
-
Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes
-
Song B, Scheuner D, Ron D, Pennathur S & Kaufman RJ 2008 Chop deletion reduces oxidative stress, improves beta cell function, and promotes cell survival in multiple mouse models of diabetes. Journal of Clinical Investigation 118 3378-3389. (doi:10.1172/JCI34587)
-
(2008)
Journal of Clinical Investigation
, vol.118
, pp. 3378-3389
-
-
Song, B.1
Scheuner, D.2
Ron, D.3
Pennathur, S.4
Kaufman, R.J.5
-
170
-
-
15944375438
-
Endoplasmic reticulum stress-induced apoptosis is partly mediated by reduced insulin signaling through phosphatidylinositol 3-kinase/Akt and increased glycogen synthase kinase-3beta in mouse insulinoma cells
-
Srinivasan S, Ohsugi M, Liu Z, Fatrai S, Bernal-Mizrachi E & Permutt MA 2005 Endoplasmic reticulum stress-induced apoptosis is partly mediated by reduced insulin signaling through phosphatidylinositol 3-kinase/Akt and increased glycogen synthase kinase-3beta in mouse insulinoma cells. Diabetes 54 968-975. (doi:10.2337/ diabetes.54.4.968)
-
(2005)
Diabetes
, vol.54
, pp. 968-975
-
-
Srinivasan, S.1
Ohsugi, M.2
Liu, Z.3
Fatrai, S.4
Bernal-Mizrachi, E.5
Permutt, M.A.6
-
171
-
-
35448994352
-
Insulin gene mutations as a cause of permanent neonatal diabetes
-
Stoy J, Edghill EL, Flanagan SE, Ye H, Paz VP, Pluzhnikov A, Below JE, Hayes MG, Cox NJ, Lipkind GM, et al. 2007 Insulin gene mutations as a cause of permanent neonatal diabetes. PNAS 104 15040-15044. (doi:10.1073/pnas.0707291104)
-
(2007)
PNAS
, vol.104
, pp. 15040-15044
-
-
Stoy, J.1
Edghill, E.L.2
Flanagan, S.E.3
Ye, H.4
Paz, V.P.5
Pluzhnikov, A.6
Below, J.E.7
Hayes, M.G.8
Cox, N.J.9
Lipkind, G.M.10
-
172
-
-
84939961892
-
Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes
-
Sun J, Cui J, He Q, Chen Z, Arvan P & Liu M 2015 Proinsulin misfolding and endoplasmic reticulum stress during the development and progression of diabetes. Molecular Aspects of Medicine 42 105-118. (doi:10.1016/j.mam.2015.01.001)
-
(2015)
Molecular Aspects of Medicine
, vol.42
, pp. 105-118
-
-
Sun, J.1
Cui, J.2
He, Q.3
Chen, Z.4
Arvan, P.5
Liu, M.6
-
173
-
-
38049052254
-
C/EBP homologous protein is crucial for the acceleration of experimental pancreatitis
-
Suyama K, Ohmuraya M, Hirota M, Ozaki N, Ida S, Endo M, Araki K, Gotoh T, Baba H & Yamamura K 2008 C/EBP homologous protein is crucial for the acceleration of experimental pancreatitis. Biochemical and Biophysical Research Communications 367 176-182. (doi:10.1016/j.bbrc.2007.12.132)
-
(2008)
Biochemical and Biophysical Research Communications
, vol.367
, pp. 176-182
-
-
Suyama, K.1
Ohmuraya, M.2
Hirota, M.3
Ozaki, N.4
Ida, S.5
Endo, M.6
Araki, K.7
Gotoh, T.8
Baba, H.9
Yamamura, K.10
-
174
-
-
84937532659
-
Resveratrol and diabetes: From animal to human studies
-
Szkudelski T & Szkudelska K 2015 Resveratrol and diabetes: from animal to human studies. Biochimica et Biophysica Acta 1852 1145-1154. (doi:10.1016/j.bbadis.2014.10.013)
-
(2015)
Biochimica et Biophysica Acta
, vol.1852
, pp. 1145-1154
-
-
Szkudelski, T.1
Szkudelska, K.2
-
175
-
-
79952264011
-
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
-
Tabas I & Ron D 2011 Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nature Cell Biology 13 184-190. (doi:10.1038/ncb0311-184)
-
(2011)
Nature Cell Biology
, vol.13
, pp. 184-190
-
-
Tabas, I.1
Ron, D.2
-
176
-
-
84868130018
-
ER stress activates NF-kappaB by integrating functions of basal IKK activity, IRE1 and PERK
-
Tam AB, Mercado EL, Hoffmann A & Niwa M 2012 ER stress activates NF-kappaB by integrating functions of basal IKK activity, IRE1 and PERK. PLoS ONE 7 e45078. (doi:10.1371/journal.pone.0045078)
-
(2012)
PLoS ONE
, vol.7
-
-
Tam, A.B.1
Mercado, E.L.2
Hoffmann, A.3
Niwa, M.4
-
177
-
-
84878363585
-
Baculoviral inhibitors of apoptosis repeat containing (BIRC) proteins fine-tune TNF-induced nuclear factor kappaB and c-Jun N-terminal kinase signalling in mouse pancreatic beta cells
-
Tan BM, Zammit NW, Yam AO, Slattery R, Walters SN, Malle E & Grey ST 2013 Baculoviral inhibitors of apoptosis repeat containing (BIRC) proteins fine-tune TNF-induced nuclear factor kappaB and c-Jun N-terminal kinase signalling in mouse pancreatic beta cells. Diabetologia 56 520-532. (doi:10.1007/s00125-012-2784-x)
-
(2013)
Diabetologia
, vol.56
, pp. 520-532
-
-
Tan, B.M.1
Zammit, N.W.2
Yam, A.O.3
Slattery, R.4
Walters, S.N.5
Malle, E.6
Grey, S.T.7
-
178
-
-
84859553400
-
Islet betacell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model
-
Tersey SA, Nishiki Y, Templin AT, Cabrera SM, Stull ND, Colvin SC, Evans-Molina C, Rickus JL, Maier B & Mirmira RG 2012 Islet betacell endoplasmic reticulum stress precedes the onset of type 1 diabetes in the nonobese diabetic mouse model. Diabetes 61 818-827. (doi:10.2337/db11-1293)
-
(2012)
Diabetes
, vol.61
, pp. 818-827
-
-
Tersey, S.A.1
Nishiki, Y.2
Templin, A.T.3
Cabrera, S.M.4
Stull, N.D.5
Colvin, S.C.6
Evans-Molina, C.7
Rickus, J.L.8
Maier, B.9
Mirmira, R.G.10
-
179
-
-
69249132997
-
Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stressbut not nitric oxide-mediated apoptosis in INS-1E cells
-
Tonnesen MF, Grunnet LG, Friberg J, Cardozo AK, Billestrup N, Eizirik DL, Storling J & Mandrup-Poulsen T 2009 Inhibition of nuclear factor-kappaB or Bax prevents endoplasmic reticulum stressbut not nitric oxide-mediated apoptosis in INS-1E cells. Endocrinology 150 4094-4103. (doi:10.1210/en.2009-0029)
-
(2009)
Endocrinology
, vol.150
, pp. 4094-4103
-
-
Tonnesen, M.F.1
Grunnet, L.G.2
Friberg, J.3
Cardozo, A.K.4
Billestrup, N.5
Eizirik, D.L.6
Storling, J.7
Mandrup-Poulsen, T.8
-
180
-
-
84919643292
-
Identification of small molecules that protect pancreatic beta cells against endoplasmic reticulum stress-induced cell death
-
Tran K, Li Y, Duan H, Arora D, Lim HY & Wang W 2014 Identification of small molecules that protect pancreatic beta cells against endoplasmic reticulum stress-induced cell death. ACS Chemical Biology 9 2796-2806. (doi:10.1021/cb500740d)
-
(2014)
ACS Chemical Biology
, vol.9
, pp. 2796-2806
-
-
Tran, K.1
Li, Y.2
Duan, H.3
Arora, D.4
Lim, H.Y.5
Wang, W.6
-
181
-
-
34247340606
-
Protection of pancreatic beta-cells by exendin-4 may involve the reduction of endoplasmic reticulum stress: In vivo and in vitro studies
-
Tsunekawa S, Yamamoto N, Tsukamoto K, Itoh Y, Kaneko Y, Kimura T, Ariyoshi Y, Miura Y, Oiso Y & Niki I 2007 Protection of pancreatic beta-cells by exendin-4 may involve the reduction of endoplasmic reticulum stress: in vivo and in vitro studies. Journal of Endocrinology 193 65-74. (doi:10.1677/JOE-06-0148)
-
(2007)
Journal of Endocrinology
, vol.193
, pp. 65-74
-
-
Tsunekawa, S.1
Yamamoto, N.2
Tsukamoto, K.3
Itoh, Y.4
Kaneko, Y.5
Kimura, T.6
Ariyoshi, Y.7
Miura, Y.8
Oiso, Y.9
Niki, I.10
-
182
-
-
0034723235
-
Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1
-
Urano F, Wang X, Bertolotti A, Zhang Y, Chung P, Harding HP & Ron D 2000 Coupling of stress in the ER to activation of JNK protein kinases by transmembrane protein kinase IRE1. Science 287 664-666. (doi:10.1126/science.287.5453.664)
-
(2000)
Science
, vol.287
, pp. 664-666
-
-
Urano, F.1
Wang, X.2
Bertolotti, A.3
Zhang, Y.4
Chung, P.5
Harding, H.P.6
Ron, D.7
-
183
-
-
78751662679
-
Type 1 diabetes: Etiology, immunology, and therapeutic strategies
-
van Belle TL, Coppieters KT & von Herrath MG 2011 Type 1 diabetes: etiology, immunology, and therapeutic strategies. Physiological Reviews 91 79-118. (doi:10.1152/physrev.00003.2010)
-
(2011)
Physiological Reviews
, vol.91
, pp. 79-118
-
-
van Belle, T.L.1
Coppieters, K.T.2
von Herrath, M.G.3
-
184
-
-
77957301909
-
The endoplasmic reticulum stress response in the pancreatic beta-cell
-
Volchuk A & Ron D 2010 The endoplasmic reticulum stress response in the pancreatic beta-cell. Diabetes, Obesity and Metabolism 12 (Supplement 2) 48-57. (doi:10.1111/j.1463-1326.2010.01271.x)
-
(2010)
Diabetes, Obesity and Metabolism
, vol.12
, pp. 48-57
-
-
Volchuk, A.1
Ron, D.2
-
185
-
-
84943429713
-
Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells
-
Vomund AN, Zinselmeyer BH, Hughes J, Calderon B, Valderrama C, Ferris ST, Wan X, Kanekura K, Carrero JA, Urano F, et al. 2015 Beta cells transfer vesicles containing insulin to phagocytes for presentation to T cells. PNAS 112 E5496-E5502. (doi:10.1073/ pnas.1515954112)
-
(2015)
PNAS
, vol.112
, pp. E5496-E5502
-
-
Vomund, A.N.1
Zinselmeyer, B.H.2
Hughes, J.3
Calderon, B.4
Valderrama, C.5
Ferris, S.T.6
Wan, X.7
Kanekura, K.8
Carrero, J.A.9
Urano, F.10
-
186
-
-
84915782617
-
Activation of the NLRP3 inflammasome complex is not required for stress-induced death of pancreatic islets
-
Wali JA, Gurzov EN, Fynch S, Elkerbout L, Kay TW, Masters SL & Thomas HE 2014 Activation of the NLRP3 inflammasome complex is not required for stress-induced death of pancreatic islets. PLoS ONE 9 e113128. (doi:10.1371/journal.pone.0113128)
-
(2014)
PLoS ONE
, vol.9
-
-
Wali, J.A.1
Gurzov, E.N.2
Fynch, S.3
Elkerbout, L.4
Kay, T.W.5
Masters, S.L.6
Thomas, H.E.7
-
187
-
-
82255173966
-
The unfolded protein response: From stress pathway to homeostatic regulation
-
Walter P & Ron D 2011 The unfolded protein response: from stress pathway to homeostatic regulation. Science 334 1081-1086. (doi:10.1126/science.1209038)
-
(2011)
Science
, vol.334
, pp. 1081-1086
-
-
Walter, P.1
Ron, D.2
-
188
-
-
0033050865
-
Differential display PCR reveals novel targets for the mood-stabilizing drug valproate including the molecular chaperone GRP78
-
Wang JF, Bown C & Young LT 1999 Differential display PCR reveals novel targets for the mood-stabilizing drug valproate including the molecular chaperone GRP78. Molecular Pharmacology 55 521-527.
-
(1999)
Molecular Pharmacology
, vol.55
, pp. 521-527
-
-
Wang, J.F.1
Bown, C.2
Young, L.T.3
-
189
-
-
71049146229
-
Suppression of p38 MAPK and JNK via Akt-mediated inhibition of apoptosis signal-regulating kinase 1 constitutes a core component of the beta-cell pro-survival effects of glucose-dependent insulinotropic polypeptide
-
Widenmaier SB, Ao Z, Kim SJ, Warnock G & McIntosh CH 2009 Suppression of p38 MAPK and JNK via Akt-mediated inhibition of apoptosis signal-regulating kinase 1 constitutes a core component of the beta-cell pro-survival effects of glucose-dependent insulinotropic polypeptide. Journal of Biological Chemistry 284 30372-30382. (doi:10.1074/jbc.M109.060178)
-
(2009)
Journal of Biological Chemistry
, vol.284
, pp. 30372-30382
-
-
Widenmaier, S.B.1
Ao, Z.2
Kim, S.J.3
Warnock, G.4
McIntosh, C.H.5
-
190
-
-
79952410092
-
Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and beta-cell dysfunction in humans
-
Xiao C, Giacca A & Lewis GF 2011 Sodium phenylbutyrate, a drug with known capacity to reduce endoplasmic reticulum stress, partially alleviates lipid-induced insulin resistance and beta-cell dysfunction in humans. Diabetes 60 918-924. (doi:10.2337/ db10-1433)
-
(2011)
Diabetes
, vol.60
, pp. 918-924
-
-
Xiao, C.1
Giacca, A.2
Lewis, G.F.3
-
191
-
-
33745202552
-
WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic betacells
-
Yamada T, Ishihara H, Tamura A, Takahashi R, Yamaguchi S, Takei D, Tokita A, Satake C, Tashiro F, Katagiri H, et al. 2006 WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic betacells. Human Molecular Genetics 15 1600-1609. (doi:10.1093/hmg/ ddl081)
-
(2006)
Human Molecular Genetics
, vol.15
, pp. 1600-1609
-
-
Yamada, T.1
Ishihara, H.2
Tamura, A.3
Takahashi, R.4
Yamaguchi, S.5
Takei, D.6
Tokita, A.7
Satake, C.8
Tashiro, F.9
Katagiri, H.10
-
192
-
-
84875992503
-
Involvement of ASK1-p38 pathway in the pathogenesis of diabetes triggered by pancreatic ss cell exhaustion
-
Yamaguchi K, Takeda K, Kadowaki H, Ueda I, Namba Y, Ouchi Y, Nishitoh H & Ichijo H 2013 Involvement of ASK1-p38 pathway in the pathogenesis of diabetes triggered by pancreatic ss cell exhaustion. Biochimica et Biophysica Acta 1830 3656-3663. (doi:10.1016/j.bbagen.2013.01.029)
-
(2013)
Biochimica et Biophysica Acta
, vol.1830
, pp. 3656-3663
-
-
Yamaguchi, K.1
Takeda, K.2
Kadowaki, H.3
Ueda, I.4
Namba, Y.5
Ouchi, Y.6
Nishitoh, H.7
Ichijo, H.8
-
193
-
-
69849109361
-
Activation of the Akt-NF-kappaB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response
-
Yamazaki H, Hiramatsu N, Hayakawa K, Tagawa Y, Okamura M, Ogata R, Huang T, Nakajima S, Yao J, Paton AW, et al. 2009 Activation of the Akt-NF-kappaB pathway by subtilase cytotoxin through the ATF6 branch of the unfolded protein response. Journal of Immunology 183 1480-1487. (doi:10.4049/jimmunol.0900017)
-
(2009)
Journal of Immunology
, vol.183
, pp. 1480-1487
-
-
Yamazaki, H.1
Hiramatsu, N.2
Hayakawa, K.3
Tagawa, Y.4
Okamura, M.5
Ogata, R.6
Huang, T.7
Nakajima, S.8
Yao, J.9
Paton, A.W.10
-
194
-
-
84887977565
-
Pathological endoplasmic reticulum stress mediated by the IRE1 pathway contributes to pre-insulitic beta cell apoptosis in a virus-induced rat model of type 1 diabetes
-
Yang C, Diiorio P, Jurczyk A, O'Sullivan-Murphy B, Urano F & Bortell R 2013 Pathological endoplasmic reticulum stress mediated by the IRE1 pathway contributes to pre-insulitic beta cell apoptosis in a virus-induced rat model of type 1 diabetes. Diabetologia 56 2638-2646. (doi:10.1007/s00125-013-3044-4)
-
(2013)
Diabetologia
, vol.56
, pp. 2638-2646
-
-
Yang, C.1
Diiorio, P.2
Jurczyk, A.3
O'Sullivan-Murphy, B.4
Urano, F.5
Bortell, R.6
-
195
-
-
84897018309
-
Toll-like receptor 2/4 links to free fatty acid-induced inflammation and beta-cell dysfunction
-
Yin J, Peng Y, Wu J, Wang Y & Yao L 2014 Toll-like receptor 2/4 links to free fatty acid-induced inflammation and beta-cell dysfunction. Journal of Leukocyte Biology 95 47-52. (doi:10.1189/jlb.0313143)
-
(2014)
Journal of Leukocyte Biology
, vol.95
, pp. 47-52
-
-
Yin, J.1
Peng, Y.2
Wu, J.3
Wang, Y.4
Yao, L.5
-
196
-
-
84987819153
-
Thioredoxin/Txnip: Redoxisome, as a redox switch for the pathogenesis of diseases
-
Yoshihara E, Masaki S, Matsuo Y, Chen Z, Tian H & Yodoi J 2014 Thioredoxin/Txnip: redoxisome, as a redox switch for the pathogenesis of diseases. Frontiers in Immunology 4 514. (doi:10.3389/ fimmu.2013.00514)
-
(2014)
Frontiers in Immunology
, vol.4
, pp. 514
-
-
Yoshihara, E.1
Masaki, S.2
Matsuo, Y.3
Chen, Z.4
Tian, H.5
Yodoi, J.6
-
197
-
-
33750448469
-
GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress
-
Yusta B, Baggio LL, Estall JL, Koehler JA, Holland DP, Li H, Pipeleers D, Ling Z & Drucker DJ 2006 GLP-1 receptor activation improves beta cell function and survival following induction of endoplasmic reticulum stress. Cell Metabolism 4 391-406. (doi:10.1016/j. cmet.2006.10.001)
-
(2006)
Cell Metabolism
, vol.4
, pp. 391-406
-
-
Yusta, B.1
Baggio, L.L.2
Estall, J.L.3
Koehler, J.A.4
Holland, D.P.5
Li, H.6
Pipeleers, D.7
Ling, Z.8
Drucker, D.J.9
-
198
-
-
77956917631
-
XBP-1 couples endoplasmic reticulum stress to augmented IFN-beta induction via a cis-acting enhancer in macrophages
-
Zeng L, Liu YP, Sha H, Chen H, Qi L & Smith JA 2010 XBP-1 couples endoplasmic reticulum stress to augmented IFN-beta induction via a cis-acting enhancer in macrophages. Journal of Immunology 185 2324-2330. (doi:10.4049/jimmunol.0903052)
-
(2010)
Journal of Immunology
, vol.185
, pp. 2324-2330
-
-
Zeng, L.1
Liu, Y.P.2
Sha, H.3
Chen, H.4
Qi, L.5
Smith, J.A.6
-
199
-
-
0029417129
-
TNF-alpha inhibits glucose-induced insulin secretion in a pancreatic beta-cell line (INS-1)
-
Zhang S & Kim KH 1995 TNF-alpha inhibits glucose-induced insulin secretion in a pancreatic beta-cell line (INS-1). FEBS Letters 377 237-239. (doi:10.1016/0014-5793(95)01272-9)
-
(1995)
FEBS Letters
, vol.377
, pp. 237-239
-
-
Zhang, S.1
Kim, K.H.2
-
200
-
-
14944371187
-
The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis
-
Zhang K, Wong HN, Song B, Miller CN, Scheuner D & Kaufman RJ 2005 The unfolded protein response sensor IRE1alpha is required at 2 distinct steps in B cell lymphopoiesis. Journal of Clinical Investigation 115 268-281. (doi:10.1172/JCI200521848)
-
(2005)
Journal of Clinical Investigation
, vol.115
, pp. 268-281
-
-
Zhang, K.1
Wong, H.N.2
Song, B.3
Miller, C.N.4
Scheuner, D.5
Kaufman, R.J.6
-
201
-
-
80053952176
-
Valproate protects the retina from endoplasmic reticulum stress-induced apoptosis after ischemia-reperfusion injury
-
Zhang Z, Tong N, Gong Y, Qiu Q, Yin L, Lv X & Wu X 2011 Valproate protects the retina from endoplasmic reticulum stress-induced apoptosis after ischemia-reperfusion injury. Neuroscience Letters 504 88-92. (doi:10.1016/j.neulet.2011.09.003)
-
(2011)
Neuroscience Letters
, vol.504
, pp. 88-92
-
-
Zhang, Z.1
Tong, N.2
Gong, Y.3
Qiu, Q.4
Yin, L.5
Lv, X.6
Wu, X.7
-
202
-
-
84948419955
-
Endothelialspecific X-box binding protein 1 deficiency limits tumor necrosis factor-induced leukocyte recruitment and vasculitis
-
Ziogas A, Muders MH, Economopoulou M, Sprott D, Grossklaus S, Siegert G, Baretton GB, Mitroulis I & Chavakis T 2015 Endothelialspecific X-box binding protein 1 deficiency limits tumor necrosis factor-induced leukocyte recruitment and vasculitis. Arthritis & Rheumatology 67 3279-3285. (doi:10.1002/art.39309)
-
(2015)
Arthritis & Rheumatology
, vol.67
, pp. 3279-3285
-
-
Ziogas, A.1
Muders, M.H.2
Economopoulou, M.3
Sprott, D.4
Grossklaus, S.5
Siegert, G.6
Baretton, G.B.7
Mitroulis, I.8
Chavakis, T.9
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