Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs

Diabetologia

Volumn 50, Issue 5, 2007, Pages 1006-1014

  Pirot, P ^a   Naamane, N ^a   Libert, F ^a   Magnusson, N E ^b   Orntoft T F ^b   Cardozo, A K ^a   Eizirik, D L ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Apoptosis; CPA; Cyclopiazonic acid; Diabetes mellitus; Endoplasmic reticulum stress; Insulin; Interleukin 1; Pancreatic beta cells

Indexed keywords

CYCLOPIAZONIC ACID; INSULIN; MESSENGER RNA;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL DIFFERENTIATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DNA MODIFICATION; ENDOPLASMIC RETICULUM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; MICROARRAY ANALYSIS; MOLECULAR DYNAMICS; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA DEGRADATION;

CELL LINE; CELL SURVIVAL; CELLS, CULTURED; ENDOPLASMIC RETICULUM; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HUMANS; INDOLES; INSULIN; INSULIN-SECRETING CELLS; KINETICS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; POLYMERASE CHAIN REACTION; RNA, MESSENGER; STRESS, MECHANICAL;

EID: 34147106529     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-007-0609-0     Document Type: Article

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