Cytokines induce endoplasmic reticulum stress in human, rat and mouse beta cells via different mechanisms

Diabetologia

Volumn 58, Issue 10, 2015, Pages 2307-2316

  Brozzi, Flora ^a   Nardelli, Tarlliza R ^a   Lopes, Miguel ^a   Millard, Isabelle ^a   Barthson, Jenny ^a   Igoillo Esteve, Mariana ^a   Grieco, Fabio A ^a   Villate, Olatz ^a   Oliveira, Joana M ^a   Casimir, Marina ^a   Bugliani, Marco ^b   Engin, Feyza ^c   Hotamisligil, Gökhan S ^d   Marchetti, Piero ^b   Eizirik, Decio L ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b UNIVERSITY OF PISA   (Italy)

^c UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

Apoptosis; c Jun N terminal kinase; Cytokines; ER stress; Human islets; Type 1 diabetes

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; ACTIVATING TRANSCRIPTION FACTOR 4; CCAAT ENHANCER BINDING PROTEIN; CHAPERONE; GAMMA INTERFERON; IMMUNOGLOBULIN; INTERLEUKIN 1BETA; MESSENGER RNA; NITRIC OXIDE; STRESS ACTIVATED PROTEIN KINASE; TAUROURSODEOXYCHOLIC ACID; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; ENZYME INHIBITOR; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INDUCIBLE NITRIC OXIDE SYNTHASE; N(G) METHYLARGININE; TAUROCHENODEOXYCHOLIC ACID;

ANIMAL CELL; ANIMAL CELL CULTURE; APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; MALE; METABOLISM; SIGNAL TRANSDUCTION; WISTAR RAT;

ANIMALS; CELL LINE; CELL SURVIVAL; CYTOKINES; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITORS; HUMANS; INSULIN-SECRETING CELLS; INTERFERON-GAMMA; INTERLEUKIN-1BETA; MALE; MICE; NITRIC OXIDE SYNTHASE TYPE II; OMEGA-N-METHYLARGININE; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; TAUROCHENODEOXYCHOLIC ACID; TRANSCRIPTION FACTOR CHOP; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84942195054     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-015-3669-6     Document Type: Article

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