Valproate pretreatment protects pancreatic β-cells from palmitate-induced ER stress and apoptosis by inhibiting glycogen synthase kinase-3β

Journal of Biomedical Science

Volumn 21, Issue 1, 2014, Pages

  Huang, Shan ^a   Zhu, Minghui ^b   Wu, Wei ^a   Rashid, Abid ^a   Liang, Yan ^a   Hou, Ling ^a   Ning, Qin ^a   Luo, Xiaoping ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Wuhan Integrated TCM and Western Medicine Hospital   (China)

Author keywords

Apoptosis; Endoplasmic reticulum stress; Glycogen synthase kinase 3 ; Pancreatic cells; Valproate

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; CASPASE 3; CCAAT ENHANCER BINDING PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; MESSENGER RNA; PALMITIC ACID; VALPROIC ACID; ATF4 PROTEIN, RAT; DDIT3 PROTEIN, RAT; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; PALMITIC ACID DERIVATIVE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL LEVEL; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; ENZYME INHIBITION; LIPOTOXICITY; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ANIMAL; BIOSYNTHESIS; CELL SURVIVAL; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOLOGY;

ACTIVATING TRANSCRIPTION FACTOR 4; ANIMALS; APOPTOSIS; CELL SURVIVAL; DIABETES MELLITUS, TYPE 2; ENDOPLASMIC RETICULUM STRESS; GLYCOGEN SYNTHASE KINASE 3; HUMANS; INSULIN-SECRETING CELLS; PALMITATES; RATS; TRANSCRIPTION FACTOR CHOP; VALPROIC ACID;

EID: 84904156387     PISSN: 10217770     EISSN: 14230127     Source Type: Journal    
DOI: 10.1186/1423-0127-21-38     Document Type: Article

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