Identification of small molecules that protect pancreatic β cells against endoplasmic reticulum stress-induced cell death

ACS Chemical Biology

Volumn 9, Issue 12, 2014, Pages 2796-2806

  Tran, Kim ^a   Li, Yu ^a   Duan, Hongliang ^a   Arora, Daleep ^a   Lim, Hui Ying ^a   Wang, Weidong ^a  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BIM PROTEIN; BREFELDIN A; CASPASE 3; CYTOPROTECTIVE AGENT; DEMECLOCYCLINE; DERACOXIB; DIMETHYL SULFOXIDE; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; INITIATION FACTOR 2ALPHA; PALMITIC ACID; PROTEIN BAD; PROTEIN BAX; PROTEIN NOXA; PUMA PROTEIN; SPECTINOMYCIN; STRESS ACTIVATED PROTEIN KINASE; TELITHROMYCIN; THAPSIGARGIN; TUNICAMYCIN; INSULIN; MOLECULAR LIBRARY; PROTECTIVE AGENT;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DIABETES MELLITUS; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; GENE EXPRESSION; GLUCOSE STIMULATED INSULIN SECRETION; HEK293 CELL LINE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; INSULIN RELEASE; INSULIN SYNTHESIS; INSULINOMA CELL LINE; MOLECULAR LIBRARY; MOLECULE; MOUSE; NICK END LABELING; NONHUMAN; OPEN READING FRAME; PANCREAS ISLET BETA CELL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RNA TRANSLATION; SARCOPLASMIC RETICULUM; SECRETORY CELL; SMALL MOLECULE; UNFOLDED PROTEIN RESPONSE; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL LINE; CHEMISTRY; CYTOLOGY; DRUG DEVELOPMENT; DRUG EFFECTS; GENETICS; METABOLISM; PHARMACOLOGY; PHYSIOLOGICAL STRESS; PRIMARY CELL CULTURE; SECRETION (PROCESS); SIGNAL TRANSDUCTION;

RODENTIA;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; CASPASE 3; CELL LINE; CELL SURVIVAL; DRUG DISCOVERY; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INSULIN; INSULIN-SECRETING CELLS; MICE; PALMITIC ACID; PRIMARY CELL CULTURE; PROTECTIVE AGENTS; SIGNAL TRANSDUCTION; SMALL MOLECULE LIBRARIES; STRESS, PHYSIOLOGICAL; TUNICAMYCIN; UNFOLDED PROTEIN RESPONSE;

EID: 84919643292     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb500740d     Document Type: Article

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