WFS1-deficiency increases endoplasmic reticulum stress, impairs cell cycle progression and triggers the apoptotic pathway specifically in pancreatic β-cells

Human Molecular Genetics

Volumn 15, Issue 10, 2006, Pages 1600-1609

  Yamada, Takahiro ^a   Ishihara, Hisamitsu ^a   Tamura, Akira ^a   Takahashi, Rui ^a   Yamaguchi, Suguru ^a   Takei, Daisuke ^a   Tokita, Ai ^a   Satake, Chihiro ^a   Tashiro, Fumi ^b   Katagiri, Hideki ^a   Aburatani, Hiroyuki ^c   Miyazaki, Jun Ichi ^b   Oka, Yoshitomo ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CASPASE 3; CHAPERONE; CYCLIN DEPENDENT KINASE INHIBITOR 1; GLUCOSE REGULATED PROTEIN 78; MEMBRANE PROTEIN; PROTEIN KINASE; PROTEIN WFS1; THAPSIGARGIN; UNCLASSIFIED DRUG; VIRUS T ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BROWN ADIPOSE TISSUE; CELL CLONE; CELL COUNT; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL LOSS; CELL MUTANT; CELL SPECIFICITY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENE MUTATION; GENE OVEREXPRESSION; GENETIC CODE; HEART MUSCLE; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN DETERMINATION; PROTEIN EXPRESSION; SIMIAN VIRUS 40; SKELETAL MUSCLE; UPREGULATION; WOLFRAM SYNDROME;

ADIPOSE TISSUE, BROWN; ANIMALS; ANTIGENS, VIRAL, TUMOR; APOPTOSIS; CELL CYCLE; CELL LINE; CYCLIN-DEPENDENT KINASE INHIBITOR P21; ENDOPLASMIC RETICULUM; ENZYME INHIBITORS; INSULIN-SECRETING CELLS; MALE; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MICE, MUTANT STRAINS; MUSCLE, SKELETAL; MUTATION; MYOCARDIUM; PHOSPHORYLATION; SIMIAN VIRUS 40; THAPSIGARGIN; UP-REGULATION;

SIMIAN VIRUS 40;

EID: 33745202552     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddl081     Document Type: Article

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