-
1
-
-
78651303018
-
Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to β-cell apoptosis
-
Allagnat F, Cunha D, Moore F, Vanderwinden JM, Eizirik DL, Cardozo AK. (2011). Mcl-1 downregulation by pro-inflammatory cytokines and palmitate is an early event contributing to β-cell apoptosis. Cell Death Differ 18: 328-337.
-
(2011)
Cell Death Differ
, vol.18
, pp. 328-337
-
-
Allagnat, F.1
Cunha, D.2
Moore, F.3
Vanderwinden, J.M.4
Eizirik, D.L.5
Cardozo, A.K.6
-
3
-
-
77954515294
-
Time for testing incretin therapies in early type 1 diabetes?
-
Bosi E. (2010). Time for testing incretin therapies in early type 1 diabetes? J Clin Endocrinol Metab 95: 2607-2609.
-
(2010)
J Clin Endocrinol Metab
, vol.95
, pp. 2607-2609
-
-
Bosi, E.1
-
4
-
-
19944432792
-
Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic β-cells
-
Cardozo AK, Ortis F, Storling J, Feng YM, Rasschaert J, TonnesenM et al. (2005). Cytokines downregulate the sarcoendoplasmic reticulum pump Ca2+ ATPase 2b and deplete endoplasmic reticulum Ca2+, leading to induction of endoplasmic reticulum stress in pancreatic β-cells. Diabetes 54: 452-461.
-
(2005)
Diabetes
, vol.54
, pp. 452-461
-
-
Cardozo, A.K.1
Ortis, F.2
Storling, J.3
Feng, Y.M.4
Rasschaert, J.5
Tonnesen, M.6
-
5
-
-
70349644648
-
Islet β-cells deficient in Bcl-xL develop but are abnormally sensitive to apoptotic stimuli
-
Carrington EM, McKenzie MD, Jansen E, Myers M, Fynch S, Kos C et al. (2009). Islet β-cells deficient in Bcl-xL develop but are abnormally sensitive to apoptotic stimuli. Diabetes 58: 2316-2323.
-
(2009)
Diabetes
, vol.58
, pp. 2316-2323
-
-
Carrington, E.M.1
McKenzie, M.D.2
Jansen, E.3
Myers, M.4
Fynch, S.5
Kos, C.6
-
6
-
-
77649326700
-
MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic β-cell responses to the viral by-product double-stranded RNA
-
Colli ML, Moore F, Gurzov EN, Ortis F, Eizirik DL. (2010). MDA5 and PTPN2, two candidate genes for type 1 diabetes, modify pancreatic β-cell responses to the viral by-product double-stranded RNA. Hum Mol Genet 19: 135-146.
-
(2010)
Hum Mol Genet
, vol.19
, pp. 135-146
-
-
Colli, M.L.1
Moore, F.2
Gurzov, E.N.3
Ortis, F.4
Eizirik, D.L.5
-
7
-
-
49649084031
-
Initiation and execution of lipotoxic ER stress in pancreatic β-cells
-
Cunha DA, Hekerman P, Ladriere L, Bazarra-Castro A, Ortis F, Wakeham MC et al. (2008). Initiation and execution of lipotoxic ER stress in pancreatic β-cells. J Cell Sci 121: 2308-2318.
-
(2008)
J Cell Sci
, vol.121
, pp. 2308-2318
-
-
Cunha, D.A.1
Hekerman, P.2
Ladriere, L.3
Bazarra-Castro, A.4
Ortis, F.5
Wakeham, M.C.6
-
8
-
-
73249116246
-
Glucagon-like peptide-1 agonists protect pancreatic β-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB
-
Cunha DA, Ladriere L, Ortis F, Igoillo-Esteve M, Gurzov EN, Lupi R et al. (2009). Glucagon-like peptide-1 agonists protect pancreatic β-cells from lipotoxic endoplasmic reticulum stress through upregulation of BiP and JunB. Diabetes 58: 2851-2862.
-
(2009)
Diabetes
, vol.58
, pp. 2851-2862
-
-
Cunha, D.A.1
Ladriere, L.2
Ortis, F.3
Igoillo-Esteve, M.4
Gurzov, E.N.5
Lupi, R.6
-
9
-
-
0242691046
-
AP-1: A double-edged sword in tumorigenesis
-
Eferl R, Wagner EF. (2003). AP-1: a double-edged sword in tumorigenesis. Nat Rev Cancer 3: 859-868. (Pubitemid 37383716)
-
(2003)
Nature Reviews Cancer
, vol.3
, Issue.11
, pp. 859-868
-
-
Eferl, R.1
Wagner, E.F.2
-
10
-
-
67649364114
-
The role of inflammation in insulitis and β-cell loss in type 1 diabetes
-
Eizirik DL, ColliML, Ortis F. (2009). The role of inflammation in insulitis and β-cell loss in type 1 diabetes. Nat Rev Endocrinol 5: 219-226.
-
(2009)
Nat Rev Endocrinol
, vol.5
, pp. 219-226
-
-
Eizirik, D.L.1
Colli, M.L.2
Ortis, F.3
-
11
-
-
0035668779
-
A choice of death - The signal-transduction of immune-mediated beta-cell apoptosis
-
DOI 10.1007/s001250100021
-
Eizirik DL, Mandrup-Poulsen T. (2001). A choice of death - the signal-transduction of immune-mediated β-cell apoptosis. Diabetologia 44: 2115-2133. (Pubitemid 34015464)
-
(2001)
Diabetologia
, vol.44
, Issue.12
, pp. 2115-2133
-
-
Eizirik, D.L.1
Mandrup-Poulsen, T.2
-
12
-
-
67650751080
-
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes
-
Galluzzi L, Aaronson SA, Abrams J, Alnemri ES, Andrews DW, Baehrecke EH et al. (2009). Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ 16: 1093-1107.
-
(2009)
Cell Death Differ
, vol.16
, pp. 1093-1107
-
-
Galluzzi, L.1
Aaronson, S.A.2
Abrams, J.3
Alnemri, E.S.4
Andrews, D.W.5
Baehrecke, E.H.6
-
13
-
-
77953755226
-
p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic β-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress
-
Gurzov EN, Germano CM, Cunha DA, Ortis F, Vanderwinden JM, Marchetti P et al. (2010). p53 up-regulated modulator of apoptosis (PUMA) activation contributes to pancreatic β-cell apoptosis induced by proinflammatory cytokines and endoplasmic reticulum stress. J Biol Chem 285: 19910-19920.
-
(2010)
J Biol Chem
, vol.285
, pp. 19910-19920
-
-
Gurzov, E.N.1
Germano, C.M.2
Cunha, D.A.3
Ortis, F.4
Vanderwinden, J.M.5
Marchetti, P.6
-
14
-
-
51849098591
-
JunB inhibits ER stress and apoptosis in pancreatic beta cells
-
Gurzov EN, Ortis F, Bakiri L, Wagner EF, Eizirik DL. (2008). JunB inhibits ER stress and apoptosis in pancreatic beta cells. PLoS ONE 3: e3030.
-
(2008)
PLoS ONE
, vol.3
-
-
Gurzov, E.N.1
Ortis, F.2
Bakiri, L.3
Wagner, E.F.4
Eizirik, D.L.5
-
15
-
-
70350028224
-
Signaling by IL-1β+IFN-γ and ER stress converge on DP5/ Hrk activation: A novel mechanism for pancreatic β-cell apoptosis
-
Gurzov EN, Ortis F, Cunha DA, Gosset G, Li M, Cardozo AK et al. (2009). Signaling by IL-1β+IFN-γ and ER stress converge on DP5/ Hrk activation: a novel mechanism for pancreatic β-cell apoptosis. Cell Death Differ 16: 1539-1550.
-
(2009)
Cell Death Differ
, vol.16
, pp. 1539-1550
-
-
Gurzov, E.N.1
Ortis, F.2
Cunha, D.A.3
Gosset, G.4
Li, M.5
Cardozo, A.K.6
-
16
-
-
0035488777
-
Inhibition of Cytokine-Induced NF-κB Activation by Adenovirus-Mediated Expression of a NF-κB Super-Repressor Prevents κ-Cell Apoptosis
-
Heimberg H, Heremans Y, Jobin C, Leemans R, Cardozo AK, Darville M et al. (2001). Inhibition of cytokine-induced NF-κB activation by adenovirus-mediated expression of a NF-κB super-repressor prevents β-cell apoptosis. Diabetes 50: 2219-2224. (Pubitemid 33641904)
-
(2001)
Diabetes
, vol.50
, Issue.10
, pp. 2219-2224
-
-
Heimberg, H.1
Heremans, Y.2
Jobin, C.3
Leemans, R.4
Cardozo, A.K.5
Darville, M.6
Eizirik, D.L.7
-
17
-
-
1642458354
-
Activating Transcription Factor 3 Is Integral to the Eukaryotic Initiation Factor 2 Kinase Stress Response
-
DOI 10.1128/MCB.24.3.1365-1377.2004
-
Jiang HY, Wek SA, McGrath BC, Lu D, Hai T, Harding HP et al. (2004). Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response.Mol Cell Biol 24: 1365-1377. (Pubitemid 38112196)
-
(2004)
Molecular and Cellular Biology
, vol.24
, Issue.3
, pp. 1365-1377
-
-
Jiang, H.-Y.1
Wek, S.A.2
McGrath, B.C.3
Lu, D.4
Hai, T.5
Harding, H.P.6
Wang, X.7
Ron, D.8
Cavener, D.R.9
Wek, R.C.10
-
18
-
-
75649138332
-
Expression of stress-response ATF3 is mediated by Nrf2 in astrocytes
-
Kim KH, Jeong JY, Surh YJ, Kim KW. (2010). Expression of stress-response ATF3 is mediated by Nrf2 in astrocytes. Nucleic Acids Res 38: 48-59.
-
(2010)
Nucleic Acids Res
, vol.38
, pp. 48-59
-
-
Kim, K.H.1
Jeong, J.Y.2
Surh, Y.J.3
Kim, K.W.4
-
19
-
-
0025748778
-
cAMP-dependent regulation of proenkephalin by JunD and JunB: Positive and negative effects of AP-1 proteins
-
Kobierski LA, Chu HM, Tan Y, Comb MJ. (1991). cAMP-dependent regulation of proenkephalin by JunD and JunB: positive and negative effects of AP-1 proteins. Proc Natl Acad Sci USA 88: 10222-10226. (Pubitemid 21915807)
-
(1991)
Proceedings of the National Academy of Sciences of the United States of America
, vol.88
, Issue.22
, pp. 10222-10226
-
-
Kobierski, L.A.1
Chu, H.-M.2
Tan, Y.3
Comb, M.J.4
-
20
-
-
13444292904
-
Histone modifications defining active genes persist after transcriptional and mitotic in activation
-
DOI 10.1038/sj.emboj.7600516
-
Kouskouti A, Talianidis I. (2005). Histone modifications defining active genes persist after transcriptional and mitotic inactivation. Embo J 24: 347-357. (Pubitemid 40216139)
-
(2005)
EMBO Journal
, vol.24
, Issue.2
, pp. 347-357
-
-
Kouskouti, A.1
Talianidis, I.2
-
21
-
-
0242363618
-
Discovery of Gene Networks Regulating Cytokine-Induced Dysfunction and Apoptosis in Insulin-Producing INS-1 Cells
-
DOI 10.2337/diabetes.52.11.2701
-
Kutlu B, Cardozo AK, Darville MI, Kruhoffer M, Magnusson N, Orntoft T et al. (2003). Discovery of gene networks regulating cytokine-induced dysfunction and apoptosis in insulin-producing INS-1 cells. Diabetes 52: 2701-2719. (Pubitemid 37339700)
-
(2003)
Diabetes
, vol.52
, Issue.11
, pp. 2701-2719
-
-
Kutlu, B.1
Cardozo, A.K.2
Darville, M.I.3
Kruhoffer, M.4
Magnusson, N.5
Orntoft, T.6
Eizirik, D.L.7
-
22
-
-
0036315888
-
Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: Evidence that β-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated
-
Lupi R, Dotta F, Marselli L, Del Guerra S, Masini M, Santangelo C et al. (2002). Prolonged exposure to free fatty acids has cytostatic and pro-apoptotic effects on human pancreatic islets: evidence that β-cell death is caspase mediated, partially dependent on ceramide pathway, and Bcl-2 regulated. Diabetes 51: 1437-1442. (Pubitemid 34826609)
-
(2002)
Diabetes
, vol.51
, Issue.5
, pp. 1437-1442
-
-
Lupi, R.1
Dotta, F.2
Marselli, L.3
Del, G.S.4
Masini, M.5
Santangelo, C.6
Patane, G.7
Boggi, U.8
Piro, S.9
Anello, M.10
Bergamini, E.11
Mosca, F.12
Di, M.U.13
Del, P.S.14
Marchetti, P.15
-
23
-
-
54349119151
-
The glucagon-like peptide-1 receptor agonist oxyntomodulin enhances β-cell function but does not inhibit gastric emptying in mice
-
Maida A, Lovshin JA, Baggio LL, Drucker DJ. (2008). The glucagon-like peptide-1 receptor agonist oxyntomodulin enhances β-cell function but does not inhibit gastric emptying in mice. Endocrinology 149: 5670-5678.
-
(2008)
Endocrinology
, vol.149
, pp. 5670-5678
-
-
Maida, A.1
Lovshin, J.A.2
Baggio, L.L.3
Drucker, D.J.4
-
24
-
-
77954258871
-
Regulation of MafA expression in pancreatic β-cells in db/db mice with diabetes
-
Matsuoka TA, Kaneto H, Miyatsuka T, Yamamoto T, Yamamoto K, Kato K et al. (2010). Regulation of MafA expression in pancreatic β-cells in db/db mice with diabetes. Diabetes 59: 1709-1720.
-
(2010)
Diabetes
, vol.59
, pp. 1709-1720
-
-
Matsuoka, T.A.1
Kaneto, H.2
Miyatsuka, T.3
Yamamoto, T.4
Yamamoto, K.5
Kato, K.6
-
25
-
-
48649094094
-
Epidermal JunB represses G-CSF transcription and affects haematopoiesis and bone formation
-
Meixner A, Zenz R, Schonthaler HB, Kenner L, Scheuch H, Penninger JM et al. (2008). Epidermal JunB represses G-CSF transcription and affects haematopoiesis and bone formation. Nat Cell Biol 10: 1003-1011.
-
(2008)
Nat Cell Biol
, vol.10
, pp. 1003-1011
-
-
Meixner, A.1
Zenz, R.2
Schonthaler, H.B.3
Kenner, L.4
Scheuch, H.5
Penninger, J.M.6
-
26
-
-
66649132790
-
PTPN2, a candidate gene for type 1 diabetes, modulates interferon-γ-induced pancreatic β-cell apoptosis
-
Moore F, Colli ML, Cnop M, Esteve MI, Cardozo AK, Cunha DA et al. (2009). PTPN2, a candidate gene for type 1 diabetes, modulates interferon-γ- induced pancreatic β-cell apoptosis. Diabetes 58: 1283-1291.
-
(2009)
Diabetes
, vol.58
, pp. 1283-1291
-
-
Moore, F.1
Colli, M.L.2
Cnop, M.3
Esteve, M.I.4
Cardozo, A.K.5
Cunha, D.A.6
-
27
-
-
78651389664
-
STAT1 is a master regulator of pancreatic beta cells apoptosis and islet inflammation
-
Moore F, Naamane N, Colli ML, Bouckenooghe T, Ortis F, Gurzov EN et al. (2011). STAT1 is a master regulator of pancreatic beta cells apoptosis and islet inflammation. J Biol Chem 286: 929-941.
-
(2011)
J Biol Chem
, vol.286
, pp. 929-941
-
-
Moore, F.1
Naamane, N.2
Colli, M.L.3
Bouckenooghe, T.4
Ortis, F.5
Gurzov, E.N.6
-
28
-
-
0027142054
-
Transcriptional regulatory elements downstream of the JunB gene
-
DOI 10.1073/pnas.90.24.11960
-
Perez-Albuerne ED, Schatteman G, Sanders LK, Nathans D. (1993). Transcriptional regulatory elements downstream of the JunB gene. Proc Natl Acad Sci USA 90: 11960-11964. (Pubitemid 24008760)
-
(1993)
Proceedings of the National Academy of Sciences of the United States of America
, vol.90
, Issue.24
, pp. 11960-11964
-
-
Perez-Albuerne, E.D.1
Schatteman, G.2
Sanders, L.K.3
Nathans, D.4
-
29
-
-
73949099325
-
Epidermal loss of JunB leads to a SLE phenotype due to hyper IL-6 signaling
-
Pflegerl P, Vesely P, Hantusch B, Schlederer M, Zenz R, Janig E et al. (2009). Epidermal loss of JunB leads to a SLE phenotype due to hyper IL-6 signaling. Proc Natl Acad Sci USA 106: 20423-20428.
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 20423-20428
-
-
Pflegerl, P.1
Vesely, P.2
Hantusch, B.3
Schlederer, M.4
Zenz, R.5
Janig, E.6
-
30
-
-
0021854805
-
A new in vitro model for the study of pancreatic A and B cells
-
Pipeleers DG, in't Veld PA, Van de Winkel M, Maes E, Schuit FC, Gepts W. (1985). A new in vitro model for the study of pancreatic A and B cells. Endocrinology 117: 806-816.
-
(1985)
Endocrinology
, vol.117
, pp. 806-816
-
-
Pipeleers, D.G.1
In't Veld, P.A.2
Van De Winkel, M.3
Maes, E.4
Schuit, F.C.5
Gepts, W.6
-
31
-
-
77954889411
-
Growth factor stimulation induces cell survival by c-Jun. ATF2-dependent activation of Bcl-XL
-
Salameh A, Galvagni F, Anselmi F, De Clemente C, Orlandini M, Oliviero S. (2010). Growth factor stimulation induces cell survival by c-Jun. ATF2-dependent activation of Bcl-XL. J Biol Chem 285: 23096-23104.
-
(2010)
J Biol Chem
, vol.285
, pp. 23096-23104
-
-
Salameh, A.1
Galvagni, F.2
Anselmi, F.3
De Clemente, C.4
Orlandini, M.5
Oliviero, S.6
-
32
-
-
33846995958
-
Critical role for NF-κB-induced JunB in VEGF regulation and tumor angiogenesis
-
Schmidt D, Textor B, Pein OT, Licht AH, Andrecht S, Sator-Schmitt M et al. (2007). Critical role for NF-κB-induced JunB in VEGF regulation and tumor angiogenesis. Embo J 26: 710-719.
-
(2007)
Embo J
, vol.26
, pp. 710-719
-
-
Schmidt, D.1
Textor, B.2
Pein, O.T.3
Licht, A.H.4
Andrecht, S.5
Sator-Schmitt, M.6
-
33
-
-
0029872366
-
The human ubiquitin C promoter directs high ubiquitous expression of transgenes in mice
-
DOI 10.1093/nar/24.9.1787
-
Schorpp M, Jager R, Schellander K, Schenkel J, Wagner EF, Weiher H et al. (1996). The human ubiquitin C promoter directs high ubiquitous expression of transgenes in mice. Nucleic Acids Res 24: 1787-1788. (Pubitemid 26137941)
-
(1996)
Nucleic Acids Research
, vol.24
, Issue.9
, pp. 1787-1788
-
-
Schorpp, M.1
Jager, R.2
Schellander, K.3
Schenkel, J.4
Wagner, E.F.5
Weiher, H.6
Angel, P.7
-
34
-
-
0036098552
-
AP-1 as a regulator of cell life and death
-
DOI 10.1038/ncb0502-e131
-
Shaulian E, Karin M. (2002). AP-1 as a regulator of cell life and death. Nat Cell Biol 4: E131-E136. (Pubitemid 34521026)
-
(2002)
Nature Cell Biology
, vol.4
, Issue.5
-
-
Shaulian, E.1
Karin, M.2
-
35
-
-
23044439446
-
Stress response gene ATF3 is a target of c-myc in serum-induced cell proliferation
-
DOI 10.1038/sj.emboj.7600742
-
Tamura K, Hua B, Adachi S, Guney I, Kawauchi J, Morioka M et al. (2005). Stress response gene ATF3 is a target of c-myc in serum-induced cell proliferation. Embo J 24: 2590-2601. (Pubitemid 41076315)
-
(2005)
EMBO Journal
, vol.24
, Issue.14
, pp. 2590-2601
-
-
Tamura, K.1
Hua, B.2
Adachi, S.3
Guney, I.4
Kawauchi, J.5
Morioka, M.6
Tamamori-Adachi, M.7
Tanaka, Y.8
Nakabeppu, Y.9
Sunamori, M.10
Sedivy, J.M.11
Kitajima, S.12
-
36
-
-
70449518082
-
ATF3 transcription factor and its emerging roles in immunity and cancer
-
Thompson MR, Xu D, Williams BR. (2009). ATF3 transcription factor and its emerging roles in immunity and cancer. JMol Med 87: 1053-1060.
-
(2009)
JMol Med
, vol.87
, pp. 1053-1060
-
-
Thompson, M.R.1
Xu, D.2
Williams, B.R.3
-
37
-
-
77952716949
-
Opposing roles for calcineurin and ATF3 in squamous skin cancer
-
Wu X, Nguyen BC, Dziunycz P, Chang S, Brooks Y, Lefort K et al. (2010). Opposing roles for calcineurin and ATF3 in squamous skin cancer. Nature 465: 368-372.
-
(2010)
Nature
, vol.465
, pp. 368-372
-
-
Wu, X.1
Nguyen, B.C.2
Dziunycz, P.3
Chang, S.4
Brooks, Y.5
Lefort, K.6
-
38
-
-
25144497098
-
Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins
-
DOI 10.1038/nature03963, PII N03963
-
Zenz R, Eferl R, Kenner L, Florin L, Hummerich L, Mehic D et al. (2005). Psoriasis-like skin disease and arthritis caused by inducible epidermal deletion of Jun proteins. Nature 437: 369-375. (Pubitemid 41613493)
-
(2005)
Nature
, vol.437
, Issue.7057
, pp. 369-375
-
-
Zenz, R.1
Eferl, R.2
Kenner, L.3
Florin, L.4
Hummerich, L.5
Mehic, D.6
Scheuch, H.7
Angel, P.8
Tschachler, E.9
Wagner, E.F.10
-
39
-
-
77954825385
-
The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic β-cell dysfunction
-
Zmuda EJ, Qi L, Zhu MX, Mirmira RG, Montminy MR, Hai T. (2010a). The roles of ATF3, an adaptive-response gene, in high-fat-diet-induced diabetes and pancreatic β-cell dysfunction. Mol Endocrinol 24: 1423-1433.
-
(2010)
Mol Endocrinol
, vol.24
, pp. 1423-1433
-
-
Zmuda, E.J.1
Qi, L.2
Zhu, M.X.3
Mirmira, R.G.4
Montminy, M.R.5
Hai, T.6
-
40
-
-
77954828927
-
Deficiency of Atf3, an adaptive-response gene, protects islets and ameliorates inflammation in a syngeneic mouse transplantation model
-
Zmuda EJ, Viapiano M, Grey ST, Hadley G, Garcia-Ocana A, Hai T. (2010b). Deficiency of Atf3, an adaptive-response gene, protects islets and ameliorates inflammation in a syngeneic mouse transplantation model. Diabetologia 53: 1438-1450.
-
(2010)
Diabetologia
, vol.53
, pp. 1438-1450
-
-
Zmuda, E.J.1
Viapiano, M.2
Grey, S.T.3
Hadley, G.4
Garcia-Ocana, A.5
Hai, T.6
|