Chemical chaperones reduce ER stress and restore glucose homeostasis in a mouse model of type 2 diabetes

Science

Volumn 313, Issue 5790, 2006, Pages 1137-1140

  Özcan, Umut ^a   Yilmaz, Erkan ^a   Özcan, Lale ^a   Furuhashi, Masato ^a   Vaillancourt, Eric ^a   Smith, Ross O ^a   Görgün, Cem Z ^a   Hotamisligil, Gökhan S ^a  

^a HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASES; GLUCOSE; HORMONES; STRESS ANALYSIS; TISSUE;

ADIPOSE TISSUES; ENDOPLASMIC RETICULUM (ER); OBESITY;

BIOLOGICAL MEMBRANES;

4 PHENYLBUTYRIC ACID; CHAPERONE; URSODEOXYCHOLIC ACID;

BIOASSAY; CARBOXYLIC ACID; DIABETES; DISEASE TREATMENT; MODEL; OBESITY; RODENT;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GLUCOSE HOMEOSTASIS; HYPERGLYCEMIA; INSULIN METABOLISM; INSULIN RESISTANCE; INSULIN SENSITIVITY; MOLECULAR MECHANICS; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; STRESS;

ADIPOSE TISSUE; ANIMALS; BLOOD GLUCOSE; CELL LINE, TUMOR; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; EIF-2 KINASE; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; EUKARYOTIC INITIATION FACTOR-2; GLUCOSE; GLUCOSE TOLERANCE TEST; HOMEOSTASIS; INSULIN; INSULIN RESISTANCE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER; MICE; MICE, OBESE; PHENYLBUTYRATES; PHOSPHORYLATION; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TAUROCHENODEOXYCHOLIC ACID;

ANIMALIA;

EID: 33748069813     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1128294     Document Type: Article

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15. We thank J. Kim and G. I. Shulman for training and advice on the hyperinsulinemic-euglycemic clamp experiments and R. J. Foote for administrative assistance. Supported by NIH grant DK52539 to G.S.H. M.F is supported by a postdoctoral fellowship from the Japan Society for the Promotion of Science. L.O. is supported by the American Diabetes Association mentor-based postdoctoral fellowship.