Endoplasmic reticulum stress contributes to beta cell apoptosis in type 2 diabetes

Diabetologia

Volumn 50, Issue 4, 2007, Pages 752-763

  Laybutt, D R ^a   Preston, A M ^a   Akerfeldt M C ^a   Kench, J G ^a   Busch, A K ^a   Biankin, A V ^a   Biden, T J ^a,b  

^a ST VINCENT S HOSPITAL   (Australia)

^b GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

Apoptosis; Endoplasmic reticulum stress; Fatty acids; Islets; Pancreatic beta cells; Type 2 diabetes

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; CHAPERONE; GLUCOSE REGULATED PROTEIN 78; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; HEAT SHOCK PROTEIN; HEAT SHOCK PROTEIN 40; INSULIN; LIPID; MESSENGER RNA; OLEIC ACID; PALMITIC ACID; PROTEIN DNAJ; PROTEIN P58; X BOX BINDING PROTEIN 1;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; CELL ISOLATION; CELL PROTECTION; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE MODEL; ENDOPLASMIC RETICULUM STRESS; EVALUATION; GENE EXPRESSION; GENE OVEREXPRESSION; HUMAN; HUMAN TISSUE; INSULIN RELEASE; MARKER GENE; MOUSE; MOUSE STRAIN; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PANCREAS; PANCREAS ISLET CELL; PRIORITY JOURNAL; PROTEIN PROCESSING; TISSUE SECTION; UPREGULATION;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL LINE; DIABETES MELLITUS, TYPE 2; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION; HEAT-SHOCK PROTEINS; HUMANS; INSULIN-SECRETING CELLS; LIPIDS; MICE; MICE, INBRED C57BL; MOLECULAR CHAPERONES; OXIDATIVE STRESS; RNA, MESSENGER;

EID: 33847677975     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-006-0590-z     Document Type: Article

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